Laura Pope Hale

Journal article Comp Med · February 2009 Featured Publication Infection of mouse colonies with Helicobacter spp. has become an increasing concern for the research community. Although Helicobacter infection may cause clinical disease, investigators may be unaware that their laboratory mice are infected because the pat ... Link to item Cite

Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice.

Journal article Comp Med · December 2008 Featured Publication Infection with Helicobacter species is endemic in many animal facilities and may alter the penetrance of inflammatory bowel disease (IBD) phenotypes. However, little is known about the relative pathogenicity of H. typhlonius, H. rodentium, and combined inf ... Link to item Cite

Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad.

Journal article Am J Physiol Gastrointest Liver Physiol · December 2008 Featured Publication The complex interaction of genetic, microbial, and environmental factors may result in continuous activation of the mucosal immune system leading to inflammatory bowel disease (IBD). Most present treatments for IBD involve altering or suppressing the aberr ... Full text Link to item Cite

Helicobacter infection decreases reproductive performance of IL10-deficient mice.

Journal article Comp Med · October 2008 Featured Publication Infections with a variety of Helicobacter species have been documented in rodent research facilities, with variable effects on rodent health. Helicobacter typhlonius has been reported to cause enteric disease in immunodeficient and IL10(-/-) mice, whereas ... Link to item Cite

Bromelain treatment decreases neutrophil migration to sites of inflammation.

Journal article Clin Immunol · July 2008 Featured Publication Bromelain, a mixture of proteases derived from pineapple stem, has been reported to have therapeutic benefits in a variety of inflammatory diseases, including murine inflammatory bowel disease. The purpose of this work was to understand potential mechanism ... Full text Link to item Cite

Treatment of experimental colitis in mice with LMP-420, an inhibitor of TNF transcription.

Journal article J Inflamm (Lond) · March 10, 2008 Featured Publication BACKGROUND: LMP-420 is a boronic acid-containing purine nucleoside analogue that transcriptionally inhibits TNF production but is non-cytotoxic to TNF-producing cells. METHODS: This study investigated the efficacy of LMP-420 as an anti-inflammatory agent i ... Full text Link to item Cite

Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro.

Journal article Clin Immunol · March 2008 Featured Publication Oral bromelain has been anecdotally reported to decrease inflammation in ulcerative colitis (UC). Proteolytically active bromelain is known to decrease expression of mRNAs encoding pro-inflammatory cytokines by human leukocytes in vitro. To assess the effe ... Full text Link to item Cite

Neonatal co-infection with helicobacter species markedly accelerates the development of inflammation-associated colonic neoplasia in IL-10(-/-) mice.

Journal article Helicobacter · December 2007 Featured Publication BACKGROUND: Inflammatory bowel disease (IBD) is hypothesized to represent an aberrant immune response against enteric bacteria that occurs in a genetically susceptible host. Humans and mice with IBD are at markedly increased risk for colonic neoplasia. How ... Full text Link to item Cite

Oral immunogenicity of the plant proteinase bromelain.

Journal article Int Immunopharmacol · December 20, 2006 Featured Publication Bromelain is a natural mixture of proteolytic enzymes derived from pineapple stem that has been shown to have anti-inflammatory activity when administered orally. Although most proteins given orally without adjuvant (e.g., food) result in tolerance, we pre ... Full text Link to item Cite

Piroxicam treatment of IL-10-deficient mice enhances colonic epithelial apoptosis and mucosal exposure to intestinal bacteria.

Journal article Inflamm Bowel Dis · December 2005 Featured Publication Treatment with the nonsteroidal anti-inflammatory drugs piroxicam or sulindac was recently shown to accelerate the development of colitis in interleukin (IL)-10-deficient (IL-10) mice. Although NSAIDs have been hypothesized to decrease the barrier function ... Full text Link to item Cite

Treatment with oral bromelain decreases colonic inflammation in the IL-10-deficient murine model of inflammatory bowel disease.

Journal article Clin Immunol · August 2005 Featured Publication Bromelain is a mixture of proteinases derived from pineapple stem that is marketed in health food stores as a "digestive aid". Orally administered bromelain was anecdotally reported to induce clinical and endoscopic remission of ulcerative colitis in two p ... Full text Link to item Cite

Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease.

Journal article J Clin Microbiol · July 2005 Featured Publication The composition and spatial organization of the mucosal flora in biopsy specimens from patients with inflammatory bowel disease (IBD; either Crohn's disease or ulcerative colitis), self-limiting colitis, irritable-bowel syndrome (IBS), and healthy controls ... Full text Link to item Cite

Spatial organization of bacterial flora in normal and inflamed intestine: a fluorescence in situ hybridization study in mice.

Journal article World J Gastroenterol · February 28, 2005 Featured Publication AIM: To study the role of intestinal flora in inflammatory bowel disease (IBD). METHODS: The spatial organization of intestinal flora was investigated in normal mice and in two models of murine colitis using fluorescence in situ hybridization. RESULTS: The ... Full text Link to item Cite

Bromelain treatment alters leukocyte expression of cell surface molecules involved in cellular adhesion and activation.

Journal article Clin Immunol · August 2002 Featured Publication Bromelain is a natural proteinase preparation derived from pineapple stem that is marketed for oral use as a digestive aid and as an antiinflammatory agent. Bromelain treatment in vitro has been previously shown to selectively remove certain cell surface m ... Full text Link to item Cite