Current Appointments & Affiliations
Assistant Professor of Pediatrics
·
2023 - Present
Pediatrics, Rheumatology,
Pediatrics
Recent Publications
Interferon-β-Induced Injury During Pediatric Muscle Differentiation: Insight Into Juvenile Dermatomyositis Pathogenesis.
Journal Article ACR Open Rheumatol · January 2025 OBJECTIVE: Juvenile dermatomyositis (JDM) involves up-regulated type I interferons (IFNs), including IFNβ, yet pathologic mechanisms remain poorly understood. We aimed to characterize the functional and structural effects of IFNβ on in vitro human pediatri ... Full text Link to item CiteGenetic changes from type I interferons and JAK inhibitors: clues to drivers of juvenile dermatomyositis.
Journal Article Rheumatology (Oxford) · September 1, 2024 OBJECTIVE: To better understand the pathogenesis of juvenile dermatomyositis (JDM), we examined the effect of the cytokines type I interferons (IFN I) and JAK inhibitor drugs (JAKi) on gene expression in bioengineered pediatric skeletal muscle. METHODS: My ... Full text Link to item CiteEffect of type I interferon on engineered pediatric skeletal muscle: a promising model for juvenile dermatomyositis.
Journal Article Rheumatology (Oxford) · January 4, 2024 OBJECTIVE: To investigate pathogenic mechanisms underlying JDM, we defined the effect of type I IFN, IFN-α and IFN-β, on pediatric skeletal muscle function and expression of myositis-related proteins using an in vitro engineered human skeletal muscle model ... Full text Link to item CiteRecent Grants
Using Bioengineered Human Muscle to Develop Treatments for Juvenile Dermatomyositis
ResearchPrincipal Investigator · Awarded by Hartwell Foundation · 2025 - 2028Using bioengineered human muscle to understand mechanisms of juvenile dermatomyositis
ResearchPrincipal Investigator · Awarded by Childhood Arthritis & Rheumatology Research Alliance, Inc. · 2025 - 2026Cell-free mitochondrial DNA induces type I interferon production in an experimental myobundle model of juvenile dermatomyositis (JDM).
ResearchPostdoctoral Associate · Awarded by Cure JM Foundation · 2022 - 2023View All Grants
Education, Training & Certifications
Georgetown University, School of Medicine ·
2016
M.D.