Laurie D. Snyder

Journal article Am J Transplant · March 2012 Featured Work Cytomegalovirus (CMV) is the most prevalent opportunistic infection that occurs in lung-transplant recipients. In addition to its direct morbidity, multiple studies have demonstrated that CMV, in particular CMV pneumonia, is associated with an increased ri ... Full text Link to item Cite

Spirometrically significant acute rejection increases the risk for BOS and death after lung transplantation.

Journal article Am J Transplant · March 2012 Featured Work Acute rejection (AR) is a common complication following lung transplantation and is an established risk factor for bronchiolitis obliterans syndrome (BOS). AR clinical presentation varies considerably and is sometimes associated with an acute decrease in f ... Full text Link to item Cite

Long-term efficacy and safety of 12 months of valganciclovir prophylaxis compared with 3 months after lung transplantation: a single-center, long-term follow-up analysis from a randomized, controlled cytomegalovirus prevention trial.

Journal article J Heart Lung Transplant · September 2011 Featured Work BACKGROUND: The optimal approach to cytomegalovirus (CMV) prevention after lung transplantation is controversial. We recently completed a prospective, randomized, placebo-controlled study of CMV prevention in lung transplantation that demonstrated the shor ... Full text Link to item Cite

Polyfunctional cytomegalovirus-specific immunity in lung transplant recipients receiving valganciclovir prophylaxis.

Journal article Am J Transplant · March 2011 Featured Work Cytomegalovirus (CMV) is a common opportunistic infection after lung transplant. Despite effective antiviral medications to treat CMV, invasive CMV disease contributes to lung allograft dysfunction and worse survival. Efforts to prevent CMV have led to the ... Full text Link to item Cite

Survival after bronchiolitis obliterans syndrome among bilateral lung transplant recipients.

Journal article Am J Respir Crit Care Med · September 15, 2010 Featured Work RATIONALE: Despite the importance of bronchiolitis obliterans syndrome (BOS) in lung transplantation, little is known regarding the factors that influence survival after the onset of this condition, particularly among bilateral transplant recipients. OBJEC ... Full text Link to item Cite

Cytomegalovirus pneumonitis is a risk for bronchiolitis obliterans syndrome in lung transplantation.

Journal article Am J Respir Crit Care Med · June 15, 2010 Featured Work RATIONALE: Cytomegalovirus pneumonitis is one of the most prevalent opportunistic infections after lung transplantation. Early studies reported that cytomegalovirus pneumonitis was a risk factor for chronic allograft dysfunction. More recently, in the era ... Full text Link to item Cite

Rabbit anti-thymocyte globulin induction therapy does not prolong survival after lung transplantation.

Journal article J Heart Lung Transplant · May 2008 Featured Work BACKGROUND: Lung transplant survival is limited by the development of bronchiolitis obliterans syndrome (BOS). The strongest risk factor for BOS is acute rejection (AR). We have previously shown that rabbit anti-thymocyte globulin (RATG) induction therapy ... Full text Link to item Cite

Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14.

Journal article Am J Transplant · March 2007 Featured Work We have developed the hypothesis that genetic polymorphisms which alter the expression or function of innate immune receptors contribute to the marked interindividual differences in the onset and severity of lung transplant rejection. In this analysis, we ... Full text Link to item Cite

Cytokine gene polymorphisms are not associated with bronchiolitis obliterans syndrome or survival after lung transplant.

Journal article J Heart Lung Transplant · November 2006 Featured Work BACKGROUND: Cytokine polymorphisms are inconsistently associated with transplant rejection and other adverse outcomes. To address this controversy, we evaluated cytokine single nucleotide polymorphisms (SNPs) in a lung transplant cohort. METHODS: All patie ... Full text Link to item Cite

Immune mechanisms of lung allograft rejection.

Journal article Semin Respir Crit Care Med · October 2006 Featured Work Extended survival after lung transplantation is primarily limited by progressive airflow obstruction and fibrotic obliteration of the small airways, termed bronchiolitis obliterans syndrome (BOS) and bronchiolitis obliterans (BO), respectively. BO is thoug ... Full text Link to item Cite