Scholars@Duke
Laurie D. Snyder

Laurie D. Snyder

Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
Duke Box 103002, Durham, NC 27710
DUMC 103002, Durham, NC 27710

Scholarly Works - Journal articles

Assessing and Addressing Frailty in Candidates for Lung Transplantation: An ISHLT Consensus Statement.

Journal article J Heart Lung Transplant · October 2026 The ISHLT Consensus document for the selection of lung transplant candidates recommends frailty assessment as part of a comprehensive candidacy evaluation. Missing from this and other recent consensus documents were practical recommendations on which frail ... Full text Link to item Cite

Short-term air pollution exposure and hospitalizations in idiopathic pulmonary fibrosis: data from the IPF-PRO Registry.

Journal article Ann Am Thorac Soc · September 12, 2026 RATIONALE: While long-term exposure to ambient air pollution in patients with idiopathic pulmonary fibrosis (IPF) has been associated with an increased risk of disease progression and mortality, the risks associated with acute exposure are less clear. OBJE ... Full text Link to item Cite

International Society for Heart and Lung Transplantation Scientific Statement on pulmonary antibody-mediated rejection and proposed graft, antibody, and pathology (GAP) definition.

Journal article J Heart Lung Transplant · September 2026 Antibody-mediated rejection (AMR) is an increasingly recognized form of rejection and cause of graft failure after lung transplantation. AMR has been the focus of extensive research over the past decade. Despite growing awareness and recent advances in our ... Full text Link to item Cite

Re-evaluating the role of oxygen delivery and radiographs in the definition of primary graft dysfunction after lung transplantation: A Lung Transplant Outcomes Group cohort study.

Journal article J Heart Lung Transplant · August 31, 2026 BACKGROUND: Primary graft dysfunction (PGD) is severe lung injury following lung transplantation. Variable radiograph interpretation and changes in mechanical ventilation and extracorporeal membrane oxygenation (ECMO) support for hypoxemia may limit the cu ... Full text Link to item Cite

Changes in quality of life and exercise capacity following initiation of supplemental oxygen in patients with idiopathic pulmonary fibrosis

Journal article BMC Pulmonary Medicine · August 31, 2026 AbstractBackgroundIn patients with idiopathic pulmonary fibrosis (IPF), supplemental oxygen may improve symptoms but may also p ... Full text Cite

Cytomegalovirus-Cell-Mediated Immunity Assays for the Prevention and Management of Cytomegalovirus in Transplant Recipients and Patients Receiving Cellular Therapies.

Journal article Transpl Infect Dis · August 13, 2026 CMV cell-mediated immunity (CMV-CMI) testing has emerged as a promising tool to refine CMV risk stratification and inform prevention strategies in transplant recipients, while recent data assess its role in novel cellular therapies. By identifying patients ... Full text Link to item Cite

Cytomegalovirus infection after lung transplant: Incidence, risk factors, and management in a multicenter cohort.

Journal article Am J Transplant · July 22, 2026 Cytomegalovirus (CMV) infection after lung transplant is associated with chronic rejection, but risk factors besides serology are not well-defined. Utilizing a multicenter, prospective cohort, CMV infection risk factors during and after prophylaxis were an ... Full text Link to item Cite

Authors' reply.

Journal article J Heart Lung Transplant · June 2026 Full text Link to item Cite

Workplace Productivity Loss in Patients with Progressive Pulmonary Fibrosis: Data from the ILD-PRO Registry.

Journal article Lung · May 27, 2026 PURPOSE: Pulmonary fibrosis may impair an individual's ability to work. We assessed the extent, cost and factors associated with workplace productivity loss among patients with progressive pulmonary fibrosis (PPF). METHODS: The multi-center ILD-PRO Registr ... Full text Link to item Cite

Reduced lung fluid club cell secretory protein informs chronic lung allograft dysfunction risk.

Journal article Eur Respir J · April 2026 BACKGROUND: Lung transplant recipients with lower club cell secretory protein (CCSP) levels in bronchoalveolar lavage fluid (BALF) early post-transplantation are at increased risk for chronic lung allograft dysfunction (CLAD). For CLAD risk stratification, ... Full text Link to item Cite

Performance of Wearable Pulse Oximetry During Controlled Hypoxia Induction: Instrument Validation Study.

Journal article JMIR Form Res · March 27, 2026 BACKGROUND: Oxygen saturation is a crucial metric used for monitoring patients with lung disease or respiratory illness who are at risk of hypoxemia (low blood oxygen saturation). Early and accurate identification of abnormal oxygen saturation is important ... Full text Link to item Cite

Timing of quality of life and lung function changes during the first year following lung transplantation: A multicenter prospective cohort study.

Journal article J Heart Lung Transplant · March 2026 BACKGROUND: Lung transplantation (LT) has been shown to improve lung function and quality of life (QoL). We sought to clarify if QoL improvements coincide with improvements in spirometry assessments in the first post-transplant year. METHODS: In the multic ... Full text Link to item Cite

Clinical features associated with chronic lung allograft dysfunction progression in a multicenter cohort.

Journal article Am J Respir Crit Care Med · March 1, 2026 RATIONALE: Clinical features that impact outcomes in lung recipients with chronic lung allograft dysfunction (CLAD) are uncertain and limited by existing approaches to phenotyping that rely on measures inconsistently performed or not standardized across ce ... Full text Link to item Cite

Considerations for Endpoints in Lung Transplant Clinical Trials: An ISHLT Consensus Statement.

Journal article J Heart Lung Transplant · February 2026 Clinical trials in lung transplantation have been hindered by a lack of clarity on the formulation and significance of endpoints for evaluating therapeutic efficacy. To address this challenge, a multidisciplinary working group from the International Societ ... Full text Link to item Cite

Abnormal spirometry 1 year after lung transplantation may identify patients at risk for chronic lung allograft dysfunction in a multicenter cohort.

Journal article JHLT Open · February 2026 BACKGROUND: Baseline lung allograft dysfunction (BLAD) is the failure to achieve predicted pulmonary function after lung transplantation. BLAD, as defined by abnormal spirometry at 12 months post-transplant (Spiro12M), has been associated with increased mo ... Full text Link to item Cite

ISHLT Consensus Statement on Short Telomere Syndrome and Lung Transplantation.

Journal article J Heart Lung Transplant · February 2026 Motivated by growing evidence that the presence of critically shortened telomeres influences interstitial lung disease (ILD) trajectories and is associated with extrapulmonary conditions relevant to lung transplant candidacy and post-transplant complicatio ... Full text Link to item Cite

Hospitalisations in patients with idiopathic pulmonary fibrosis: insights from the IPF-PRO Registry and EMPIRE Registry.

Journal article ERJ Open Res · January 2026 BACKGROUND: We used data from the European MultiPartner IPF Registry (EMPIRE) and the US Idiopathic Pulmonary Fibrosis-PRospective Outcomes (IPF-PRO) Registry to examine the frequency of hospitalisation, risk factors associated with hospitalisation, and wh ... Full text Link to item Cite

Trajectories of Health-Related Quality of Life in Patients With Idiopathic Pulmonary Fibrosis.

Journal article CHEST Pulm · December 2025 BACKGROUND: Patients with idiopathic pulmonary fibrosis (IPF) experience impairments in health-related quality of life (HRQL). RESEARCH QUESTION: What is the trajectory of decline in HRQL in patients with IPF and is this influenced by patients' demographic ... Full text Link to item Cite

Development and validation of a bronchoalveolar lavage genomic classifier for acute cellular rejection.

Journal article EBioMedicine · December 2025 BACKGROUND: Acute cellular rejection (ACR) is the main risk factor for chronic lung allograft dysfunction (CLAD), but diagnosis requires invasive transbronchial biopsy (TBB). We previously demonstrated the feasibility of bronchoalveolar lavage cell pellet ... Full text Link to item Cite

Telehealth interventions to improve outcomes in lung transplant recipients: Primary results of the INSPIRE-III randomized clinical trial.

Journal article J Heart Lung Transplant · September 2025 BACKGROUND: There is growing evidence that many patients undergoing lung transplantation report significant distress and low physical activity (PA), which might not improve despite lung transplantation and may be associated with worse clinical outcomes. Fe ... Full text Link to item Cite

CD26/DPP-IV inhibitors and associations with chronic lung allograft dysfunction in a multicenter cohort.

Journal article J Heart Lung Transplant · September 2025 BACKGROUND: CD26/dipeptidyl peptidase 4 inhibitors (gliptins) target proinflammatory pathways that contribute to the development of chronic lung allograft dysfunction (CLAD). We analyzed longitudinal clinical data from 6 North American lung transplant cent ... Full text Link to item Cite

Basiliximab induction immunosuppression and lung transplant outcomes: Propensity analysis in a multicenter cohort.

Journal article J Heart Lung Transplant · June 2025 BACKGROUND: Basiliximab induction immunosuppression is increasingly employed in lung transplant recipients despite limited prospective evidence to support its use in this population. We sought to determine the relationship between basiliximab induction and ... Full text Link to item Cite

Predictive machine learning algorithm for COPD exacerbations using a digital inhaler with integrated sensors.

Journal article BMJ Open Respir Res · May 12, 2025 PURPOSE: By using data obtained with digital inhalers, machine learning models have the potential to detect early signs of deterioration and predict impending exacerbations of chronic obstructive pulmonary disease (COPD) for individual patients. This analy ... Full text Link to item Cite

Predictors of donation after circulatory death lung utilization and allograft survival.

Journal article J Heart Lung Transplant · April 2025 BACKGROUND: Understanding donor factors associated with successful lung transplantation (LTx) following donation after circulatory death (DCD) is important in optimizing donor management. In this study, we examined critical care and ventilatory factors ass ... Full text Link to item Cite

Predictors of Long-Term Survival in Patients with Idiopathic Pulmonary Fibrosis: Data from the IPF-PRO Registry.

Journal article Lung · March 9, 2025 PURPOSE: We used data from the IPF-PRO Registry of patients with idiopathic pulmonary fibrosis (IPF) to identify characteristics that predicted survival for a further > 5 years. METHODS: Participants had IPF that was diagnosed or confirmed at the enrolling ... Full text Link to item Cite

Identification and validation of a threshold for early posttransplant bronchoalveolar fluid hyaluronan that distinguishes lung recipients at risk for chronic lung allograft dysfunction.

Journal article J Heart Lung Transplant · March 2025 BACKGROUND: Few tools exist for the early identification of patients at risk for chronic lung allograft dysfunction (CLAD). We previously showed hyaluronan (HA), a matrix molecule that regulates lung inflammation and fibrosis, accumulates in bronchoalveola ... Full text Link to item Cite

Long-Term Air Pollution Exposure and Severity of Idiopathic Pulmonary Fibrosis: Data from the Idiopathic Pulmonary Fibrosis Prospective Outcomes (IPF-PRO) Registry.

Journal article Ann Am Thorac Soc · March 2025 Rationale: Although exposure to air pollution is a known risk factor for adverse pulmonary outcomes, its impact in individuals with idiopathic pulmonary fibrosis (IPF) is less well understood. Objectives: To investigate the effects of long-term exposure to ... Full text Link to item Cite

Prognosis and Risks for Probable Chronic Lung Allograft Dysfunction: A Prospective Multicenter Study.

Journal article Am J Respir Crit Care Med · February 2025 Rationale: Chronic lung allograft dysfunction (CLAD) hinders lung transplant success. A 2019 consensus refined CLAD diagnosis, introducing probable or definite CLAD based on persistence of lung function decline. Outcomes and risks for probable CLAD remain ... Full text Link to item Cite

Limited utility of Epstein-Barr virus (EBV) surveillance for predicting post-transplant lymphoproliferative disorders in adult EBV seropositive lung transplant recipients.

Journal article J Clin Virol · February 2025 BACKGROUND: EBV DNAemia surveillance, with reduction of immunosuppression at certain viral load (VL) thresholds, is a common practice for mitigating progression from EBV DNAemia to post-transplant lymphoproliferative disorder (PTLD) in lung transplant reci ... Full text Link to item Cite

Alterations in circulating measures of Th2 immune responses pre-lung transplant associates with reduced primary graft dysfunction.

Journal article J Heart Lung Transplant · November 2024 Primary graft dysfunction (PGD) is a complication of lung transplantation that continues to cause significant morbidity. The Th2 immune response has been shown to counteract tissue-damaging inflammation. We hypothesized that Th2 cytokines/chemokines in blo ... Full text Link to item Cite

Interrogating post-transplant donor HLA-specific antibody characteristics and effector functions using clinical bead assays.

Journal article Hum Immunol · November 2024 Single antigen bead (SAB) assays are the most common and sensitive method used to detect and monitor post-transplant donor specific HLA antibodies (DSA). However, a direct comparison across traditional and modified SAB assays to improve routine DSA monitor ... Full text Link to item Cite

Development and evaluation of a questionnaire to capture environmental and occupational inhalational exposures in adults with fibrotic interstitial lung disease.

Journal article Respir Res · October 15, 2024 BACKGROUND: Identification of exposures in patients with interstitial lung diseases (ILDs) is essential for diagnosis and management and can be facilitated through the use of exposure questionnaires. However, for most ILDs, a patient-focused questionnaire ... Full text Link to item Cite

Evaluating longitudinal cytomegalovirus-specific humoral immune responses and association with DNAemia risk in seropositive lung transplant recipients.

Journal article JHLT Open · August 2024 BACKGROUND: Cytomegalovirus (CMV) is the most common viral infection among lung transplant recipients and is associated with chronic lung allograft dysfunction. There is a need for better therapeutics as well as biomarkers to enable effective stratificatio ... Full text Link to item Cite

With Comparable Outcomes, Should Early-Stage Lung Cancer Be a Contraindication to Lung Transplant?

Journal article Ann Thorac Surg · July 2024 BACKGROUND: Active primary lung malignancy remains a strong contraindication to lung transplantation (LTx). However, outcomes are unclear for patients with early-stage non-small cell lung cancer (NSCLC) who undergo LTx. We hypothesize that patients with ea ... Full text Link to item Cite

Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates.

Journal article J Heart Lung Transplant · April 2024 BACKGROUND: Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplantation. Accurate prediction of PGD risk could inform donor approaches and perioperative care planning. We sought to develop a clinically u ... Full text Link to item Cite

The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation.

Journal article Am J Respir Crit Care Med · January 1, 2024 Rationale: Primary graft dysfunction (PGD) is the leading cause of early morbidity and mortality after lung transplantation. Prior studies implicated proxy-defined donor smoking as a risk factor for PGD and mortality. Objectives: We aimed to more accuratel ... Full text Link to item Cite

Group Versus Individual Rehabilitation in Lung Transplantation: A Retrospective Noninferiority Assessment.

Journal article Cardiopulm Phys Ther J · January 2024 PURPOSE: Pulmonary rehabilitation both before and after lung transplant is associated with improved functional exercise capacity and physical quality of life. There is wide variation in rehabilitation program provision. This study's aim was to compare the ... Full text Link to item Cite

Identifying inequities in lung transplantation: a call for strategies and future research.

Journal article JHLT Open · December 2023 Innovations in organ preservation, surgical technique, and postoperative care have transformed solid organ transplantation. As organ transplantation becomes more common, potential racial, ethnic, and socioeconomic inequities in the referral and selection p ... Full text Open Access Link to item Cite

Lung transplantation during acute exacerbations of interstitial lung disease and post-transplant survival.

Journal article JHLT Open · December 2023 BACKGROUND: Acute exacerbations of interstitial lung disease (AE-ILD) cause severe respiratory failure, and mortality is high despite treatment. Lung transplantation is an effective therapy for late-stage interstitial lung disease (ILD), but prior studies ... Full text Link to item Cite

External Control Arms in Idiopathic Pulmonary Fibrosis Using Clinical Trial and Real-World Data Sources.

Journal article Am J Respir Crit Care Med · September 1, 2023 Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease for which novel therapies are needed. External controls (ECs) could enhance IPF trial efficiency, but the direct comparability of ECs versus concurrent controls is unknown. Object ... Full text Link to item Cite

Evaluation of Frailty Measures and Short-term Outcomes After Lung Transplantation.

Journal article Chest · July 2023 BACKGROUND: Frailty, measured as a single construct, is associated variably with poor outcomes before and after lung transplantation. The usefulness of a comprehensive frailty assessment before transplantation is unknown. RESEARCH QUESTION: How are multipl ... Full text Link to item Cite

Investigating the accuracy of blood oxygen saturation measurements in common consumer smartwatches.

Journal article PLOS Digit Health · July 2023 Blood oxygen saturation (SpO2) is an important measurement for monitoring patients with acute and chronic conditions that are associated with low blood oxygen levels. While smartwatches may provide a new method for continuous and unobtrusive SpO2 monitorin ... Full text Link to item Cite

Early posttransplant reductions in club cell secretory protein associate with future risk for chronic allograft dysfunction in lung recipients: results from a multicenter study.

Journal article J Heart Lung Transplant · June 2023 BACKGROUND: Chronic lung allograft dysfunction (CLAD) increases morbidity and mortality for lung transplant recipients. Club cell secretory protein (CCSP), produced by airway club cells, is reduced in the bronchoalveolar lavage fluid (BALF) of lung recipie ... Full text Link to item Cite

Effect of Antifibrotic Therapy on Survival in Patients With Idiopathic Pulmonary Fibrosis.

Journal article Clin Ther · April 2023 PURPOSE: Real-world studies have reported reduced mortality in patients with idiopathic pulmonary fibrosis (IPF) treated with antifibrotic therapy; however, the initiation or discontinuation of therapy during these studies may have introduced bias. This st ... Full text Link to item Cite

Evaluation of host cellular responses to Epstein-Barr virus (EBV) in adult lung transplant patients with EBV-associated diseases.

Journal article J Med Virol · April 2023 Epstein-Barr virus (EBV) reactivation is commonly observed in lung transplant recipients (LTRs). However, cellular immune responses to EBV in adult LTRs have not been well described. We aimed to study CD4/CD8 ratio, EBV-specific T cells polyfunctional resp ... Full text Link to item Cite

Clinical recommendations for posttransplant assessment of anti-HLA (Human Leukocyte Antigen) donor-specific antibodies: A Sensitization in Transplantation: Assessment of Risk consensus document.

Journal article Am J Transplant · January 2023 Although anti-HLA (Human Leukocyte Antigen) donor-specific antibodies (DSAs) are commonly measured in clinical practice and their relationship with transplant outcome is well established, clinical recommendations for anti-HLA antibody assessment are sparse ... Full text Link to item Cite

Anti-fibrotic therapy and lung transplant outcomes in patients with idiopathic pulmonary fibrosis.

Journal article Ther Adv Respir Dis · 2023 BACKGROUND: It is unclear whether continuing anti-fibrotic therapy until the time of lung transplant increases the risk of complications in patients with idiopathic pulmonary fibrosis. OBJECTIVES: To investigate whether the time between discontinuation of ... Full text Link to item Cite

Prognostic implications of and clinical risk factors for acute lung injury and organizing pneumonia after lung transplantation: Data from a multicenter prospective cohort study.

Journal article Am J Transplant · December 2022 We determined prognostic implications of acute lung injury (ALI) and organizing pneumonia (OP), including timing relative to transplantation, in a multicenter lung recipient cohort. We sought to understand clinical risks that contribute to development of A ... Full text Link to item Cite

Contemporary trends in PGD incidence, outcomes, and therapies.

Journal article J Heart Lung Transplant · December 2022 BACKGROUND: We sought to describe trends in extracorporeal membrane oxygenation (ECMO) use, and define the impact on PGD incidence and early mortality in lung transplantation. METHODS: Patients were enrolled from August 2011 to June 2018 at 10 transplant c ... Full text Link to item Cite

Survival difference between high-risk and low-risk CFTR genotypes after lung transplant.

Journal article J Heart Lung Transplant · October 2022 BACKGROUND: While cystic fibrosis transmembrane conductance regulator (CFTR) genotypes are associated with clinical outcomes in cystic fibrosis patients, it is unknown if genotype impacts lung transplant outcomes. We sought to compare lung transplant survi ... Full text Link to item Cite

Plasma CXCL9 and CXCL10 at allograft injury predict chronic lung allograft dysfunction.

Journal article Am J Transplant · September 2022 Histopathologic lung allograft injuries are putative harbingers for chronic lung allograft dysfunction (CLAD). However, the mechanisms responsible are not well understood. CXCL9 and CXCL10 are potent chemoattractants of mononuclear cells and potential prop ... Full text Link to item Cite

Pretransplant physical frailty, postoperative delirium, and short-term outcomes among older lung transplant recipients.

Journal article Exp Gerontol · June 15, 2022 PURPOSE: Delirium is a common, complex medical challenge that faces surgical patients in the postoperative period. Patients undergoing lung transplantation are at especially high risk given their predisposition to physical frailty and prolonged hospitaliza ... Full text Link to item Cite

Cytomegalovirus prevention in thoracic organ transplantation: A single-center evaluation of letermovir prophylaxis.

Journal article J Heart Lung Transplant · April 2022 BACKGROUND: Cytomegalovirus (CMV) infection is common following thoracic organ transplantation and causes substantial morbidity and mortality. Letermovir is a novel antiviral agent used off-label in this population for CMV prevention. Our goal was to under ... Full text Link to item Cite

Textbook surgical outcome in lung transplantation: Analysis of a US national registry.

Journal article Clin Transplant · April 2022 INTRO: Textbook surgical outcome (TO) is a novel composite quality measure in lung transplantation (LTx). Compared to 1-year survival metrics, TO may better differentiate center performance, and motivate improvements in care. To understand the feasibility ... Full text Link to item Cite

Clinical Outcomes of Patients with Combined Idiopathic Pulmonary Fibrosis and Emphysema in the IPF-PRO Registry.

Journal article Lung · February 2022 PURPOSE: To assess the impact of concomitant emphysema on outcomes in patients with idiopathic pulmonary fibrosis (IPF). METHODS: The IPF-PRO Registry is a US registry of patients with IPF. The presence of combined pulmonary fibrosis and emphysema (CPFE) a ... Full text Link to item Cite

Associations between resources and practices of ILD centers and outcomes in patients with idiopathic pulmonary fibrosis: data from the IPF-PRO Registry.

Journal article Respir Res · January 7, 2022 BACKGROUND: Performance benchmarks for the management of idiopathic pulmonary fibrosis (IPF) have not been established. We used data from the IPF-PRO Registry, an observational registry of patients with IPF managed at sites across the US, to examine associ ... Full text Link to item Cite

Condensed Outpatient Rehabilitation Early After Lung Transplantation: A Retrospective Analysis of 6-Minute Walk Distance and Its Predictors.

Journal article Cardiopulm Phys Ther J · January 2022 PURPOSE: The objectives were to evaluate the effect of a condensed post-lung transplant outpatient rehabilitation program started immediately after hospital discharge on 6-minute walk distance (6MWD) and to explore predictors of change in 6MWD and time to ... Full text Link to item Cite

ISHLT consensus document on lung transplantation in patients with connective tissue disease: Part I: Epidemiology, assessment of extrapulmonary conditions, candidate evaluation, selection criteria, and pathology statements.

Journal article J Heart Lung Transplant · November 2021 Patients with connective tissue disease (CTD) and advanced lung disease are often considered suboptimal candidates for lung transplantation (LTx) due to their underlying medical complexity and potential surgical risk. There is substantial variability acros ... Full text Link to item Cite

Correlation between BAL CXCR3 chemokines and lung allograft histopathologies: A multicenter study.

Journal article Am J Transplant · October 2021 The histopathologic diagnosis of acute allograft injury is prognostically important in lung transplantation with evidence demonstrating a strong and consistent association between acute rejection (AR), acute lung injury (ALI), and the subsequent developmen ... Full text Link to item Cite

Hospitalizations in patients with idiopathic pulmonary fibrosis.

Journal article Respir Res · September 30, 2021 BACKGROUND: Hospitalizations are common among patients with idiopathic pulmonary fibrosis (IPF). We investigated the impact of hospitalizations on outcomes in patients with IPF. METHODS: The IPF-PRO Registry is an observational US registry that enrolled pa ... Full text Link to item Cite

Frailty and aging-associated syndromes in lung transplant candidates and recipients.

Journal article Am J Transplant · June 2021 Many lung transplant candidates and recipients are older and frailer compared to previous eras. Older patients are at increased risk for pre- and posttransplant mortality, but this risk is not explained by numerical age alone. This manuscript represents th ... Full text Link to item Cite

Effect of Antimicrobial Therapy on Respiratory Hospitalization or Death in Adults With Idiopathic Pulmonary Fibrosis: The CleanUP-IPF Randomized Clinical Trial.

Journal article JAMA · May 11, 2021 IMPORTANCE: Alteration in lung microbes is associated with disease progression in idiopathic pulmonary fibrosis. OBJECTIVE: To assess the effect of antimicrobial therapy on clinical outcomes. DESIGN, SETTING, AND PARTICIPANTS: Pragmatic, randomized, unblin ... Full text Link to item Cite

Risk of primary graft dysfunction following lung transplantation in selected adults with connective tissue disease-associated interstitial lung disease.

Journal article J Heart Lung Transplant · May 2021 BACKGROUND: Previous studies have reported similarities in long-term outcomes following lung transplantation for connective tissue disease-associated interstitial lung disease (CTD-ILD) and idiopathic pulmonary fibrosis (IPF). However, it is unknown whethe ... Full text Link to item Cite

Hyperbaric oxygen therapy to prevent central airway stenosis after lung transplantation.

Journal article J Heart Lung Transplant · April 2021 BACKGROUND: Central airway stenosis (CAS) is a severe airway complication after lung transplantation associated with bronchial ischemia and necrosis. We sought to determine whether hyperbaric oxygen therapy (HBOT), an established treatment for tissue ische ... Full text Link to item Cite

Intragraft Hyaluronan Increases in Association With Acute Lung Transplant Rejection.

Journal article Transplant Direct · April 2021 BACKGROUND: Acute perivascular rejection (AR) is common in lung recipients and increases the risk for chronic lung allograft dysfunction (CLAD). Hyaluronan (HA), an extracellular matrix constituent, accumulates in experimental AR and can act as an innate i ... Full text Link to item Cite

Lung Transplantation and the Era of the Sensitized Patient.

Journal article Front Immunol · 2021 Long term outcomes in lung transplant are limited by the development of chronic lung allograft dysfunction (CLAD). Within the past several decades, antibody-mediated rejection (AMR) has been recognized as a risk factor for CLAD. The presence of HLA antibod ... Full text Open Access Link to item Cite

Sleep quality, depressive symptoms, and transplant outcomes: Follow-up analyses from the ADAPT prospective pilot study.

Journal article Gen Hosp Psychiatry · 2021 BACKGROUND: Previous studies suggested that depressive symptoms and sleep quality may be important for long-term clinical outcomes following cardiothoracic transplant. Few studies, however, have systematically examined objective markers of these behavioral ... Full text Link to item Cite

Depression, Immunosuppressant Levels, and Clinical Outcomes in Postlung Transplant Recipients.

Journal article Int J Psychiatry Med · November 2020 OBJECTIVE: Posttransplant depression has been linked to increased risk for adverse outcomes in lung transplant patients. Maintaining target serum immunosuppressant levels is also essential for optimal lung transplant clinical outcome and may be a crucial p ... Full text Link to item Cite

Bronchoalveolar bile acid and inflammatory markers to identify high-risk lung transplant recipients with reflux and microaspiration.

Journal article J Heart Lung Transplant · September 2020 BACKGROUND: Gastroesophageal reflux disease (GERD) is a risk factor for chronic lung allograft dysfunction. Bile acids-putative markers of gastric microaspiration-and inflammatory proteins in the bronchoalveolar lavage (BAL) have been associated with chron ... Full text Link to item Cite

Skeletal muscle adiposity and outcomes in candidates for lung transplantation: a lung transplant body composition cohort study.

Journal article Thorax · September 2020 CT measurement of body composition may improve lung transplant candidate selection. We assessed whether skeletal muscle adipose deposition on abdominal and thigh CT scans was associated with 6 min walk distance (6MWD) and wait-list survival in lung transpl ... Full text Link to item Cite

Risk Factors for Acute Rejection in the First Year after Lung Transplant. A Multicenter Study.

Journal article Am J Respir Crit Care Med · August 15, 2020 Rationale: Acute rejection, manifesting as lymphocytic inflammation in a perivascular (acute perivascular rejection [AR]) or peribronchiolar (lymphocytic bronchiolitis [LB]) distribution, is common in lung transplant recipients and increases the risk for c ... Full text Link to item Cite

Perspectives on donor lung allocation from both sides of the Atlantic: The United States.

Journal article Clin Transplant · July 2020 Donor lung allocation in the United States focuses on decreasing waitlist mortality and improving recipient outcomes. The implementation of allocation policy to match deceased donor lungs to waitlisted patients occurs through a unique partnership between g ... Full text Link to item Cite

Time to diagnosis of idiopathic pulmonary fibrosis in the IPF-PRO Registry.

Journal article BMJ Open Respir Res · July 2020 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality. Patient characteristics associated with diagnostic delays are not well described. METHODS: Subjects who had not been diagnosed with IPF prior to referral and rece ... Full text Link to item Cite

Associations between Patient-reported Outcomes and Death or Lung Transplant in Idiopathic Pulmonary Fibrosis. Data from the Idiopathic Pulmonary Fibrosis Prospective Outcomes Registry.

Journal article Ann Am Thorac Soc · June 2020 Rationale: Progression of idiopathic pulmonary fibrosis (IPF) is accompanied by worsening of symptoms, exercise capacity, and health-related quality of life. However, the utility of patient-reported outcomes as predictors of mortality remains uncertain.Obj ... Full text Link to item Cite

Highlights from the clinical trials in organ transplantation (CTOT)-20 and CTOT-22 Consortium studies in lung transplant.

Journal article Am J Transplant · June 2020 Long-term survival after lung transplant lags behind that of other commonly transplanted organs, reflecting the current incomplete understanding of the mechanisms involved in the development of posttransplant lung injury, rejection, infection, and chronic ... Full text Link to item Cite

Disease Severity and Quality of Life in Patients With Idiopathic Pulmonary Fibrosis: A Cross-Sectional Analysis of the IPF-PRO Registry.

Journal article Chest · May 2020 BACKGROUND: Limited data are available on the association between clinically measured disease severity markers and quality of life (QOL) in idiopathic pulmonary fibrosis (IPF). The study examined the associations between objective disease severity metrics ... Full text Link to item Cite

Design and rationale of a multi-center, pragmatic, open-label randomized trial of antimicrobial therapy - the study of clinical efficacy of antimicrobial therapy strategy using pragmatic design in Idiopathic Pulmonary Fibrosis (CleanUP-IPF) clinical trial.

Journal article Respir Res · March 12, 2020 Compelling data have linked disease progression in patients with idiopathic pulmonary fibrosis (IPF) with lung dysbiosis and the resulting dysregulated local and systemic immune response. Moreover, prior therapeutic trials have suggested improved outcomes ... Full text Link to item Cite

Remote Therapy to Improve Outcomes in Lung Transplant Recipients: Design of the INSPIRE-III Randomized Clinical Trial.

Journal article Transplant Direct · March 2020 BACKGROUND: Impaired functional capacity and emotional distress are associated with lower quality of life (QoL) and worse clinical outcomes in post lung transplant patients. Strategies to increase physical activity and reduce distress are needed. METHODS: ... Full text Link to item Cite

Depressive symptoms, physical activity, and clinical events: The ADAPT prospective pilot study.

Journal article Clin Transplant · November 2019 BACKGROUND: Physical inactivity and depressive symptoms following cardiothoracic transplantation are recognized as potentially modifiable psychosocial factors to improve clinical outcomes. However, few studies have prospectively assessed these in ambulator ... Full text Link to item Cite

Lung Transplant Outcomes in Patients With Pulmonary Fibrosis With Telomere-Related Gene Variants.

Journal article Chest · September 2019 BACKGROUND: Pulmonary fibrosis (PF) is the most common disease indication for lung transplantation. Our recent work implicated an excess of rare genetic variants in the telomere-related genes TERT, RTEL1, and PARN in PF disease risk. The impact of such var ... Full text Link to item Cite

Predictors of death or lung transplant after a diagnosis of idiopathic pulmonary fibrosis: insights from the IPF-PRO Registry.

Journal article Respir Res · May 30, 2019 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a progressive disease with a variable clinical course and high mortality. We used data from a large national US registry of patients with IPF to investigate relationships between patient characteristics, i ... Full text Link to item Cite

Frailty in the End-Stage Lung Disease or Heart Failure Patient: Implications for the Perioperative Transplant Clinician.

Journal article J Cardiothorac Vasc Anesth · May 2019 The syndrome of frailty for patients undergoing heart or lung transplantation has been a recent focus for perioperative clinicians because of its association with postoperative complications and poor outcomes. Patients with end-stage cardiac or pulmonary f ... Full text Open Access Link to item Cite

A 1-Month Physical Therapy-Based Outpatient Program for Adults Awaiting Lung Transplantation: A Retrospective Analysis of Exercise Capacity, Symptoms, and Quality of Life.

Journal article Cardiopulm Phys Ther J · April 2019 PURPOSE: Rehabilitation can improve health outcomes in candidates for lung transplantation. The purpose of this study was to retrospectively evaluate the effect of a one-month physical therapy (PT)-based outpatient program on exercise capacity, symptoms, q ... Full text Link to item Cite

Pre-transplant weight loss and clinical outcomes after lung transplantation.

Journal article J Heart Lung Transplant · December 2018 BACKGROUND: Patients with greater adiposity before lung transplantation are at an increased risk for worse post-transplant outcomes. Few studies have addressed whether pre-transplant weight loss mitigates this risk. In this study we examined the associatio ... Full text Link to item Cite

National Heart, Lung, and Blood Institute and American Association for Thoracic Surgery Workshop Report: Identifying collaborative clinical research priorities in lung transplantation.

Journal article J Thorac Cardiovasc Surg · December 2018 This report summarizes the discussion and recommendations from the June 2017 NHLBI-AATS Workshop on Identifying Collaborative Clinical Research Priorities in Lung Transplantation. ... Full text Link to item Cite

Randomized, Double-Blind, Placebo-Controlled, Phase 2 Trial of BMS-986020, a Lysophosphatidic Acid Receptor Antagonist for the Treatment of Idiopathic Pulmonary Fibrosis.

Journal article Chest · November 2018 BACKGROUND: Idiopathic pulmonary fibrosis (IPF) causes irreversible loss of lung function. The lysophosphatidic acid receptor 1 (LPA1) pathway is implicated in IPF etiology. Safety and efficacy of BMS-986020, a high-affinity LPA1 antagonist, was assessed v ... Full text Link to item Cite

Sensitization in Transplantation: Assessment of Risk (STAR) 2017 Working Group Meeting Report.

Journal article Am J Transplant · July 2018 The presence of preexisting (memory) or de novo donor-specific HLA antibodies (DSAs) is a known barrier to successful long-term organ transplantation. Yet, despite the fact that laboratory tools and our understanding of histocompatibility have advanced sig ... Full text Link to item Cite

Depression, social support, and clinical outcomes following lung transplantation: a single-center cohort study.

Journal article Transpl Int · May 2018 Depressive symptoms are common among lung transplant candidates and have been associated with poorer clinical outcomes in some studies. Previous studies have been plagued by methodologic problems, including small sample sizes, few clinical events, and unco ... Full text Link to item Cite

Depressive Symptoms, Exercise Capacity, and Clinical Outcomes After Lung Transplantation.

Journal article Psychosom Med · May 2018 OBJECTIVE: Depressive symptoms are common among lung transplant recipients and have been associated with worse clinical outcomes. However, few studies have examined the association between depressive symptoms assessed at multiple time points or behavioral ... Full text Link to item Cite

Complement system in lung transplantation.

Journal article Clin Transplant · April 2018 The complement system is a cascade of multiple proteins that have been known to mediate inflammatory response. This tightly regulated system has been recognized to play a role in adaptive immunity via humoral and cell-mediated processes. There is evidence ... Full text Link to item Cite

Neurological Sequelae and Clinical Outcomes After Lung Transplantation.

Journal article Transplant Direct · April 2018 BACKGROUND: Neurological complications are common after lung transplantation. However, no large cohort studies have examined the incidence, predictors, and clinical significance of neurological events sustained by lung transplant recipients. METHODS: We co ... Full text Open Access Link to item Cite

Correlation between sinus and lung cultures in lung transplant patients with cystic fibrosis.

Journal article Int Forum Allergy Rhinol · March 2018 BACKGROUND: Lung transplantation has revolutionized the treatment of end-stage pulmonary disease due to cystic fibrosis. However, infection of the transplanted lungs can lead to serious complications, including graft failure and death. Although many of the ... Full text Link to item Cite

Quantitative Evidence for Revising the Definition of Primary Graft Dysfunction after Lung Transplant.

Journal article Am J Respir Crit Care Med · January 15, 2018 RATIONALE: Primary graft dysfunction (PGD) is a form of acute lung injury that occurs after lung transplantation. The definition of PGD was standardized in 2005. Since that time, clinical practice has evolved, and this definition is increasingly used as a ... Full text Link to item Cite

Survival after lung transplantation in recipients with alpha-1-antitrypsin deficiency compared to other forms of chronic obstructive pulmonary disease: a national cohort study.

Journal article Transpl Int · January 2018 Alpha-1-antitrypsin deficiency (AATD) is grouped with chronic obstructive pulmonary disease (COPD); however, this may not be appropriate. This study assessed whether AATD confers a different prognosis than COPD following lung transplantation. We employed t ... Full text Link to item Cite

Patterns and predictors of pain following lung transplantation.

Journal article Gen Hosp Psychiatry · 2018 OBJECTIVE: Our objective was to examine variability in pain levels following lung transplantation, and examine individual biopsychosocial factors influencing changes in pain. METHOD: We performed a retrospective study of a cohort of 150 patients transplant ... Full text Link to item Cite

Effect of HMG CoA reductase inhibitors on the development of chronic lung allograft dysfunction.

Journal article Clin Transplant · January 2018 Lung transplant recipients (LRs) have a reduced median 5-year survival of approximately 55% primarily due to chronic lung allograft dysfunction (CLAD). Statins have anti-inflammatory and immunomodulatory effects that may facilitate CLAD prevention. This st ... Full text Link to item Cite

Human Leukocyte Antigen Sensitization in Solid Organ Transplantation: A Primer on Terminology, Testing, and Clinical Significance for the Apheresis Practitioner.

Journal article Ther Apher Dial · October 2017 The human leukocyte antigen (HLA) system is an important immunologic barrier that must be considered for successful solid organ transplantation. Formation of donor-specific HLA antibodies in solid organ transplantation is an important cause of allograft in ... Full text Open Access Link to item Cite

Pre-transplant Sensitization for Patient Awaiting Lung Transplant: Are We Concerned?

Journal article Current Transplantation Reports · September 1, 2017 Purpose of Review: The goal of this paper is to highlight the changes in detection, management, and prognosis of pre-transplant sensitized candidates and recipients. Recent Findings: With improvements in technology, human leukocyte antigen (HLA) antibody t ... Full text Cite

The utility of 6-minute walk distance in predicting waitlist mortality for lung transplant candidates.

Journal article J Heart Lung Transplant · July 2017 BACKGROUND: The lung allocation score (LAS) has led to improved organ allocation for transplant candidates. At present, the 6-minute walk distance (6MWD) is treated as a binary categorical variable of whether or not a candidate can walk more than 150 feet ... Full text Link to item Cite

Long-term survival following kidney transplantation in previous lung transplant recipients-An analysis of the unos registry.

Journal article Clin Transplant · May 2017 BACKGROUND: Kidney transplantation has been advocated as a therapeutic option in lung recipients who develop end-stage renal disease (ESRD). This analysis outlines patterns of allograft survival following kidney transplantation in previous lung recipients ... Full text Link to item Cite

Incidence of acute cellular rejection following granulocyte colony-stimulating factor administration in lung transplantation: A retrospective case-cohort analysis.

Journal article Clin Transplant · May 2017 Granulocyte colony-stimulating factor (GCSF) is an option to treat leukopenia in lung transplant recipients. Conflicting evidence exists regarding its effects on acute cellular rejection (ACR). A retrospective, case-cohort study was conducted to assess whe ... Full text Link to item Cite

Clinical predictors and outcome implications of early readmission in lung transplant recipients.

Journal article J Heart Lung Transplant · May 2017 BACKGROUND: The purpose of this study was to identify risk factors and outcome implications for 30-day hospital readmission in lung transplant recipients. METHODS: We conducted a retrospective cohort study of lung transplant cases from a single, high-volum ... Full text Link to item Cite

Transplant size mismatch in restrictive lung disease.

Journal article Transpl Int · April 2017 To maximize the benefit of lung transplantation, the effect of size mismatch on survival in lung transplant recipients with restrictive lung disease (RLD) was examined. All single and bilateral RLD lung transplants from 1987 to 2011 in the United Network f ... Full text Link to item Cite

Adverse outcomes associated with postoperative atrial arrhythmias after lung transplantation: A meta-analysis and systematic review of the literature.

Journal article Clin Transplant · April 2017 BACKGROUND: Postoperative atrial arrhythmias (AAs) are common after lung transplantation, but studies are mixed regarding their impact on outcomes. We therefore performed this systematic review and meta-analysis to determine whether AAs after lung transpla ... Full text Link to item Cite

Antibody depletion strategy for the treatment of suspected antibody-mediated rejection in lung transplant recipients: Does it work?

Journal article Clin Transplant · March 2017 BACKGROUND: Donor-specific antibodies (DSAs) after lung transplantation correlate with poor outcomes. The ideal treatment strategy for antibody-mediated rejection AMR is not defined. Our institution implemented an aggressive multimodality protocol for the ... Full text Link to item Cite

Depressive symptoms and early mortality following lung transplantation: A pilot study.

Journal article Clin Transplant · February 2017 BACKGROUND: Impaired psychological function is common among lung transplant candidates and may affect clinical outcomes following transplantation. Although numerous studies have examined the relationship between pretransplant depression, quality of life (Q ... Full text Link to item Cite

Medication Nonadherence After Lung Transplantation in Adult Recipients.

Journal article Ann Thorac Surg · January 2017 BACKGROUND: Our objective was to identify potential avenues for resource allocation and patient advocacy to improve outcomes by evaluating the association between recipient sociodemographic and patient characteristics and medication nonadherence after lung ... Full text Link to item Cite

Repeatability of Computerized Tomography-Based Anthropomorphic Measurements of Frailty in Patients With Pulmonary Fibrosis Undergoing Lung Transplantation.

Journal article Curr Probl Diagn Radiol · 2017 PURPOSE: To determine interreader and intrareader repeatability and correlations among measurements of computerized tomography-based anthropomorphic measurements in patients with pulmonary fibrosis undergoing lung transplantation. METHODS: This was an inst ... Full text Link to item Cite

Staging of Bilateral Lung Transplantation for High-Risk Patients With Interstitial Lung Disease: One Lung at a Time.

Journal article Am J Transplant · November 2016 The choice of a single or bilateral lung transplant for interstitial lung disease (ILD) is controversial, as surgical risk, long-term survival and organ allocation are competing factors. In an effort to balance risk and benefit, our center adopted a staged ... Full text Link to item Cite

Validation and Refinement of Chronic Lung Allograft Dysfunction Phenotypes in Bilateral and Single Lung Recipients.

Journal article Ann Am Thorac Soc · May 2016 RATIONALE: The clinical course of chronic lung allograft dysfunction (CLAD) is heterogeneous. Forced vital capacity (FVC) loss at onset, which may suggest a restrictive phenotype, was associated with worse survival for bilateral lung transplant recipients ... Full text Link to item Cite

The relationship between plasma lipid peroxidation products and primary graft dysfunction after lung transplantation is modified by donor smoking and reperfusion hyperoxia.

Journal article J Heart Lung Transplant · April 2016 BACKGROUND: Donor smoking history and higher fraction of inspired oxygen (FIO2) at reperfusion are associated with primary graft dysfunction (PGD) after lung transplantation. We hypothesized that oxidative injury biomarkers would be elevated in PGD, with h ... Full text Link to item Cite

Antibody-mediated rejection of the lung: A consensus report of the International Society for Heart and Lung Transplantation.

Journal article J Heart Lung Transplant · April 2016 Antibody-mediated rejection (AMR) is a recognized cause of allograft dysfunction in lung transplant recipients. Unlike AMR in other solid-organ transplant recipients, there are no standardized diagnostic criteria or an agreed-upon definition. Hence, a work ... Full text Link to item Cite

Protein Quantitative Trait Loci Analysis Identifies Genetic Variation in the Innate Immune Regulator TOLLIP in Post-Lung Transplant Primary Graft Dysfunction Risk.

Journal article Am J Transplant · March 2016 The authors previously identified plasma plasminogen activator inhibitor-1 (PAI-1) level as a quantitative lung injury biomarker in primary graft dysfunction (PGD). They hypothesized that plasma levels of PAI-1 used as a quantitative trait could facilitate ... Full text Link to item Cite

Impact of donor and recipient hepatitis C status in lung transplantation.

Journal article J Heart Lung Transplant · February 2016 BACKGROUND: Studies of lung transplantation in the setting of donors or recipients with hepatitis C virus (HCV) have been limited but have raised concerns about outcomes associated with this infection. METHODS: Lung transplant cases in the United Network f ... Full text Link to item Cite

Polyfunctional T-Cell Signatures to Predict Protection from Cytomegalovirus after Lung Transplantation.

Journal article Am J Respir Crit Care Med · January 1, 2016 RATIONALE: Cytomegalovirus (CMV), which is one of the most common infections after lung transplantation, is associated with chronic lung allograft dysfunction and worse post-transplantation survival. Current approaches for at-risk patients include a fixed ... Full text Link to item Cite

What Is the Optimal Transplant for Older Patients With Idiopathic Pulmonary Fibrosis?

Journal article Ann Thorac Surg · November 2015 BACKGROUND: There is controversy regarding the optimal type of lung transplant--single orthotopic lung transplantation (SOLT) versus bilateral orthotopic lung transplantation (BOLT)--for patients with idiopathic pulmonary fibrosis. We performed this study ... Full text Link to item Cite

The utility of preoperative six-minute-walk distance in lung transplantation.

Journal article Am J Respir Crit Care Med · October 1, 2015 RATIONALE: The use of 6-minute-walk distance (6MWD) as an indicator of exercise capacity to predict postoperative survival in lung transplantation has not previously been well studied. OBJECTIVES: To evaluate the association between 6MWD and postoperative ... Full text Link to item Cite

Association of hospital admission and forced vital capacity endpoints with survival in patients with idiopathic pulmonary fibrosis: analysis of a pooled cohort from three clinical trials.

Journal article Lancet Respir Med · May 2015 BACKGROUND: Mortality is an impractical primary endpoint for clinical trials in patients with idiopathic pulmonary fibrosis who have mild-to-moderate physiological impairment because event rates are low. Change in forced vital capacity (FVC) is widely acce ... Full text Link to item Cite

Determining eligibility for lung transplantation: A nationwide assessment of the cutoff glomerular filtration rate.

Journal article J Heart Lung Transplant · April 2015 BACKGROUND: Historical concerns about lung transplantation in patients with a glomerular filtration rate (GFR) ≤ 50 ml/min/1.73 m(2) have not been validated. We hypothesize that a pre-transplant GFR ≤ 50 ml/min/1.73 m(2) represents a high mortality risk, e ... Full text Link to item Cite

Neutrophil extracellular traps are pathogenic in primary graft dysfunction after lung transplantation.

Journal article Am J Respir Crit Care Med · February 15, 2015 RATIONALE: Primary graft dysfunction (PGD) causes early mortality after lung transplantation and may contribute to late graft failure. No effective treatments exist. The pathogenesis of PGD is unclear, although both neutrophils and activated platelets have ... Full text Link to item Cite

Quantitative proteomics of bronchoalveolar lavage fluid in idiopathic pulmonary fibrosis.

Journal article J Proteome Res · February 6, 2015 The proteomic analysis of bronchoalveolar lavage fluid (BALF) can give insight into pulmonary disease pathology and response to therapy. Here, we describe the first gel-free quantitative analysis of BALF in idiopathic pulmonary fibrosis (IPF), a chronic an ... Full text Link to item Cite

The Chronic Kidney Disease Epidemiology Collaboration (CKDEPI) equation best characterizes kidney function in patients being considered for lung transplantation.

Journal article J Heart Lung Transplant · December 2014 BACKGROUND: Methods for direct measurement of glomerular filtration rate (GFR) are expensive and inconsistently applied across transplant centers. The Modified Diet in Renal Disease (MDRD) equation is commonly used for GFR estimation, but is inaccurate for ... Full text Link to item Cite

Differential outcomes with early and late repeat transplantation in the era of the lung allocation score.

Journal article Ann Thorac Surg · December 2014 BACKGROUND: Rates of repeat lung transplantation have increased since implementation of the lung allocation score (LAS). The purpose of this study is to compare survival between repeat (ReTx) and primary (LTx) lung transplant recipients in the LAS era. MET ... Full text Link to item Cite

Assessment of different threshold preoperative glomerular filtration rates as markers of outcomes in lung transplantation.

Journal article Ann Thorac Surg · July 2014 BACKGROUND: The evidence behind the widely used pre-lung transplant glomerular filtration rate (GFR) cutoff of 50 mL/min per 1.73 m2 is limited. This study reviews data from a large cohort to assess outcomes associated with this historical cutoff and to es ... Full text Link to item Cite

Lung transplantation in telomerase mutation carriers with pulmonary fibrosis.

Journal article Eur Respir J · July 2014 Lung transplantation is the only intervention that prolongs survival in idiopathic pulmonary fibrosis (IPF). Telomerase mutations are the most common identifiable genetic cause of IPF, and at times, the telomere defect manifests in extrapulmonary disease s ... Full text Link to item Cite

Antibody desensitization therapy in highly sensitized lung transplant candidates.

Journal article Am J Transplant · April 2014 As HLAs antibody detection technology has evolved, there is now detailed HLA antibody information available on prospective transplant recipients. Determining single antigen antibody specificity allows for a calculated panel reactive antibodies (cPRA) value ... Full text Link to item Cite

Impact of forced vital capacity loss on survival after the onset of chronic lung allograft dysfunction.

Journal article Am J Respir Crit Care Med · January 15, 2014 RATIONALE: Emerging evidence suggests a restrictive phenotype of chronic lung allograft dysfunction (CLAD) exists; however, the optimal approach to its diagnosis and clinical significance is uncertain. OBJECTIVES: To evaluate the hypothesis that spirometri ... Full text Link to item Cite

International Experience Of Lung Transplant In Telomerase Mutation Carriers With Idiopathic Pulmonary Fibrosis

Journal article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2014 Link to item Cite

A comparative analysis of bronchial stricture after lung transplantation in recipients with and without early acute rejection.

Journal article Ann Thorac Surg · September 2013 BACKGROUND: Risk factors and outcomes of bronchial stricture after lung transplantation are not well defined. An association between acute rejection and development of stricture has been suggested in small case series. We evaluated this relationship using ... Full text Link to item Cite

Use of lung allografts from brain-dead donors after cardiopulmonary arrest and resuscitation.

Journal article Am J Respir Crit Care Med · August 15, 2013 RATIONALE: Patients who progress to brain death after resuscitation from cardiac arrest have been hypothesized to represent an underused source of potential organ donors; however, there is a paucity of data regarding the viability of lung allografts after ... Full text Link to item Cite

Rituximab-associated progressive multifocal leukoencephalopathy after lung transplantation.

Journal article The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · July 1, 2013 Cite

Implications for human leukocyte antigen antibodies after lung transplantation: a 10-year experience in 441 patients.

Journal article Chest · July 2013 BACKGROUND: Long-term survival after lung transplant is limited by the development of chronic and progressive airflow obstruction, a condition known as bronchiolitis obliterans syndrome (BOS). While prior studies strongly implicate cellular rejection as a ... Full text Link to item Cite

Colonization with small conidia Aspergillus species is associated with bronchiolitis obliterans syndrome: a two-center validation study.

Journal article Am J Transplant · April 2013 Aspergillus colonization after lung transplantation may increase the risk for bronchiolitis obliterans syndrome (BOS), a disease of small airways. We hypothesized that colonization with small conidia Aspergillus species would be associated with a greater r ... Full text Link to item Cite

Significance of and risk factors for the development of central airway stenosis after lung transplantation.

Journal article Am J Transplant · February 2013 Central airways stenosis (CAS) after lung transplant is a poorly understood complication. Objectives of this study were to determine if CAS was associated with chronic rejection or worse survival after transplant as well as to identify factors associated w ... Full text Link to item Cite

Lung Transplantation For Pulmonary Complications After Bone Marrow Transplantation

Journal article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Initial Desensitization Therapy Experience In Lung Transplant Candidates With Elevated Human Leukocyte Antigen Antibodies

Journal article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2013 Link to item Cite

Epithelial clara cell injury occurs in bronchiolitis obliterans syndrome after human lung transplantation.

Journal article Am J Transplant · November 2012 Bronchiolitis obliterans syndrome (BOS) is a condition of progressive airflow obstruction that affects a majority of lung transplant recipients and limits long-term posttransplant survival. Although epithelial injury appears central to the development of B ... Full text Link to item Cite

Is prevention the best treatment? CMV after lung transplantation.

Journal article Am J Transplant · March 2012 Featured Work Cytomegalovirus (CMV) is the most prevalent opportunistic infection that occurs in lung-transplant recipients. In addition to its direct morbidity, multiple studies have demonstrated that CMV, in particular CMV pneumonia, is associated with an increased ri ... Full text Link to item Cite

Spirometrically significant acute rejection increases the risk for BOS and death after lung transplantation.

Journal article Am J Transplant · March 2012 Featured Work Acute rejection (AR) is a common complication following lung transplantation and is an established risk factor for bronchiolitis obliterans syndrome (BOS). AR clinical presentation varies considerably and is sometimes associated with an acute decrease in f ... Full text Link to item Cite

Protective role of T-bet and Th1 cytokines in pulmonary graft-versus-host disease and peribronchiolar fibrosis.

Journal article Am J Respir Cell Mol Biol · February 2012 T-box expressed in T cells (T-bet) is a critical transcription factor for T helper (Th) 1 responses. Although Th1 cells are thought to contribute to certain alloimmune responses, their role in pulmonary graft-versus-host disease (GVHD) is uncertain. We hav ... Full text Link to item Cite

Long-term efficacy and safety of 12 months of valganciclovir prophylaxis compared with 3 months after lung transplantation: a single-center, long-term follow-up analysis from a randomized, controlled cytomegalovirus prevention trial.

Journal article J Heart Lung Transplant · September 2011 Featured Work BACKGROUND: The optimal approach to cytomegalovirus (CMV) prevention after lung transplantation is controversial. We recently completed a prospective, randomized, placebo-controlled study of CMV prevention in lung transplantation that demonstrated the shor ... Full text Link to item Cite

Fundoplication after lung transplantation prevents the allograft dysfunction associated with reflux.

Journal article Ann Thorac Surg · August 2011 BACKGROUND: Gastroesophageal reflux disease (GERD) in lung recipients is associated with decreased survival and attenuated allograft function. This study evaluates fundoplication in preventing GERD-related allograft dysfunction. METHODS: Prospectively coll ... Full text Link to item Cite

Innate immune activation potentiates alloimmune lung disease independent of chemokine (C-X-C motif) receptor 3.

Journal article J Heart Lung Transplant · June 2011 BACKGROUND: Pulmonary graft-versus-host disease (GVHD) after hematopoietic cell transplant (HCT) and allograft rejection after lung transplant are parallel immunologic processes that lead to significant morbidity and mortality. Our murine model of pulmonar ... Full text Link to item Cite

Polyfunctional cytomegalovirus-specific immunity in lung transplant recipients receiving valganciclovir prophylaxis.

Journal article Am J Transplant · March 2011 Featured Work Cytomegalovirus (CMV) is a common opportunistic infection after lung transplant. Despite effective antiviral medications to treat CMV, invasive CMV disease contributes to lung allograft dysfunction and worse survival. Efforts to prevent CMV have led to the ... Full text Link to item Cite

Survival after bronchiolitis obliterans syndrome among bilateral lung transplant recipients.

Journal article Am J Respir Crit Care Med · September 15, 2010 Featured Work RATIONALE: Despite the importance of bronchiolitis obliterans syndrome (BOS) in lung transplantation, little is known regarding the factors that influence survival after the onset of this condition, particularly among bilateral transplant recipients. OBJEC ... Full text Link to item Cite

Cytomegalovirus pneumonitis is a risk for bronchiolitis obliterans syndrome in lung transplantation.

Journal article Am J Respir Crit Care Med · June 15, 2010 Featured Work RATIONALE: Cytomegalovirus pneumonitis is one of the most prevalent opportunistic infections after lung transplantation. Early studies reported that cytomegalovirus pneumonitis was a risk factor for chronic allograft dysfunction. More recently, in the era ... Full text Link to item Cite

Rituximab For The Treatment Of Humoral Rejection After Human Lung Transplant

Journal article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2010 Link to item Cite

Toll-like receptors, innate immunity and lung transplantation.

Journal article Front Biosci (Elite Ed) · June 1, 2009 Lung transplant allografts have the highest rate of rejection and shortest graft survival time among the commonly transplanted solid organs despite high levels of immunosuppression. This observation strongly indicates that mechanisms unique to the lung all ... Full text Link to item Cite

Diagnosis and outcome of early pleural space infection following lung transplantation.

Journal article Chest · February 2009 BACKGROUND: Despite the frequent occurrence of pleural effusions in lung transplant recipients, little is known about early posttransplant pleural space infections. We sought to determine the predictors and clinical significance of pleural infection in thi ... Full text Link to item Cite

Lung transplantation at Duke University.

Journal article Clin Transpl · 2009 Clinical lung transplantation continues to grow worldwide. Advances in donor selection and management have been critical to support the expanded growth of lung transplant as a therapeutic option for patients with advanced lung disease. In recent years, all ... Link to item Cite

Early CMV Pneumonitis Predicts the Development of BOS

Journal article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2009 Link to item Cite

CXCR3-Chemokine Pathway in a Model of Murine Alloimmune Lymphocytic Bronchiolitis (AlloLB).

Journal article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2009 Link to item Cite

Predictors of Survival after Onset of BOS in Lung Transplant Recipients

Journal article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2009 Link to item Cite

Clara Cell Secretory Protein as an Inflammatory Mediator in the Development of BOS.

Journal article AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2009 Link to item Cite

Rabbit anti-thymocyte globulin induction therapy does not prolong survival after lung transplantation.

Journal article J Heart Lung Transplant · May 2008 Featured Work BACKGROUND: Lung transplant survival is limited by the development of bronchiolitis obliterans syndrome (BOS). The strongest risk factor for BOS is acute rejection (AR). We have previously shown that rabbit anti-thymocyte globulin (RATG) induction therapy ... Full text Link to item Cite

Alemtuzumab in the treatment of refractory acute rejection and bronchiolitis obliterans syndrome after human lung transplantation.

Journal article Am J Transplant · December 2007 Despite substantial improvements in early survival after lung transplantation, refractory acute rejection (RAR) and bronchiolitis obliterans syndrome (BOS) remain major contributors to transplant-related morbidity and mortality. We have utilized alemtuzuma ... Full text Link to item Cite

Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide.

Journal article Transplantation · October 27, 2007 BACKGROUND: Alloimmune lung injury, characterized by perivascular lymphocytic inflammation, lymphocytic bronchiolitis (LB), and obliterative bronchiolitis (OB), causes substantial morbidity and mortality after lung transplantation and bone marrow transplan ... Full text Link to item Cite

Lung transplantation in the older patient

Journal article Current Opinion in Organ Transplantation · October 1, 2007 PURPOSE OF REVIEW: Lung transplantation remains controversial in older patients. This review will critically evaluate the current literature on the practice and outcomes in older lung transplantation recipients. RECENT FINDINGS: International Society of He ... Full text Cite

Genetic regulation of rejection and survival following human lung transplantation by the innate immune receptor CD14.

Journal article Am J Transplant · March 2007 Featured Work We have developed the hypothesis that genetic polymorphisms which alter the expression or function of innate immune receptors contribute to the marked interindividual differences in the onset and severity of lung transplant rejection. In this analysis, we ... Full text Link to item Cite

Lung transplantation at Duke University Medical Center.

Journal article Clin Transpl · 2007 Lung transplantation has undergone remarkable changes in clinical practice to address the higher rate of rejection and mortality. Our protocols include increased immunosuppression and strategies to address non-alloimmune injury, including GER. New and inno ... Link to item Cite

Cytokine gene polymorphisms are not associated with bronchiolitis obliterans syndrome or survival after lung transplant.

Journal article J Heart Lung Transplant · November 2006 Featured Work BACKGROUND: Cytokine polymorphisms are inconsistently associated with transplant rejection and other adverse outcomes. To address this controversy, we evaluated cytokine single nucleotide polymorphisms (SNPs) in a lung transplant cohort. METHODS: All patie ... Full text Link to item Cite

Immune mechanisms of lung allograft rejection.

Journal article Semin Respir Crit Care Med · October 2006 Featured Work Extended survival after lung transplantation is primarily limited by progressive airflow obstruction and fibrotic obliteration of the small airways, termed bronchiolitis obliterans syndrome (BOS) and bronchiolitis obliterans (BO), respectively. BO is thoug ... Full text Link to item Cite

Obstructive lung disease among the urban homeless.

Journal article Chest · May 2004 STUDY OBJECTIVES: Homelessness is a growing problem in the United States that may significantly impair physical health. The homeless have a high prevalence of cigarette smoking, poor nutrition, and adverse environmental exposures, which could contribute to ... Full text Link to item Cite

Leukotriene modifier use and asthma severity: how is a new medication being used by adults with asthma?

Journal article Arch Intern Med · March 22, 2004 BACKGROUND: The introduction of leukotriene modifiers, the first novel class of medications for asthma in more than 2 decades, provided an opportunity to evaluate the clinical context in which patients receive new treatments. Because milder asthma is usual ... Full text Link to item Cite

Posttransplant lymphoproliferative disorders in lung transplant

Journal article Current Opinion in Organ Transplantation · January 1, 2004 As the number of lung transplant recipients grows, so does the potential prevalence of PTLD. The recent introduction of the anti-CD20 monoclonal antibody, rituximab, into clinical practice has already improved our ability to successfully treat PTLD after l ... Full text Cite