Current Appointments & Affiliations
George Barth Geller Distinguished Professor
·
2024 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Professor of Pharmacology and Cancer Biology
·
2023 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Chair, Department of Pharmacology and Cancer Biology
·
2023 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2023 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
ATR Safeguards Epithelial-to-Mesenchymal Transition by Countering R-loops and Enabling Transcription Reprogramming.
Journal Article J Clin Invest · January 22, 2026 Transitions of cancer cells between distinct cell states, which are typically driven by transcription reprogramming, fuel tumor plasticity, metastasis, and therapeutic resistance. Whether the transitions between cell states can be therapeutically targeted ... Full text Link to item CiteSMARCAL1 is a targetable synthetic lethal therapeutic vulnerability in ATRX-deficient gliomas that use Alternative Lengthening of Telomeres.
Journal Article Neuro Oncol · January 10, 2026 BACKGROUND: Approximately 10% of cancers achieve replicative immortality through a telomerase-independent mechanism of telomere maintenance, termed Alternative Lengthening of Telomeres (ALT). ALT is particularly prevalent in certain subtypes of malignant g ... Full text Link to item CiteZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome.
Journal Article Nat Cell Biol · June 2025 DNA double-strand breaks (DSB) are among the most deleterious forms of DNA damage and, if unresolved, result in DNA mutations and chromosomal aberrations that can cause disease, including cancer. Repair of DSBs by homologous recombination requires extensiv ... Full text Link to item CiteRecent Grants
Therapeutic targeting of SMARCAL1 in therapy-resistant gliomas
ResearchCo Investigator · Awarded by National Institutes of Health · 2026 - 2031Pharmacological Sciences Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2025 - 2030Mechanisms of replication fork protection and recovery
ResearchPrincipal Investigator · Awarded by Washington University in St. Louis · 2023 - 2030View All Grants
Education
Stony Brook University ·
1999
Ph.D.