Current Duke Appointments & Affiliations
George Barth Geller Distinguished Professor
·
2024 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Professor of Pharmacology and Cancer Biology
·
2023 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Chair, Department of Pharmacology and Cancer Biology
·
2023 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2023 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Scholarly Works
CDK2 Inhibition Exerts RB-Independent Antitumor Activity in CDK4/6 Inhibitor-Resistant HR+/HER2- Breast Cancer.
Journal article Cancer Res · October 2, 2026 UNLABELLED: Intrinsic and acquired resistance to CDK4/6 inhibitors (CDK4/6i) is a critical challenge in hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (MBC). CDK2 inhibitors (CDK2i) show ... Full text Link to item CiteReplication stress in cancer: origins, consequences and therapeutic opportunities.
Journal article Nat Rev Cancer · September 22, 2026 Replication stress, defined as impaired DNA replication leading to genomic instability, is a central feature of tumour development and progression. In cancer cells, it arises from oncogene activation, transcription-replication conflicts, altered nucleotide ... Full text Link to item CiteCapturing ATR-ATRIP in the act of activation.
Journal article Nat Struct Mol Biol · September 17, 2026 Full text Link to item CiteRecent Grants
Genetics and Genomics Training Grant
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2026 - 2031ABL kinase signaling networks regulate Transcription-Replication Collisions in Small Cell Lung Cancer
ResearchCollaborating Investigator · Awarded by National Institutes of Health · 2026 - 2031Therapeutic targeting of SMARCAL1 in therapy-resistant gliomas
ResearchCo Investigator · Awarded by National Institutes of Health · 2026 - 2031View All Grants
Education
Stony Brook University ·
1999
Ph.D.