Current Appointments & Affiliations
George Barth Geller Distinguished Professor
·
2024 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Professor of Pharmacology and Cancer Biology
·
2023 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Chair, Department of Pharmacology and Cancer Biology
·
2023 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2023 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Gap resection matters in BRCA mutant cancer.
Journal Article Genes Dev · May 2, 2025 Cancer cells deficient in BRCA1/2 have impaired DNA repair, making them sensitive to PARP inhibitors (PARPis). In this issue of Genes & Development, Seppa and colleagues (doi:10.1101/gad.352421.124) investigated how BRCA1 protects single-stranded DNA gaps ... Full text Link to item CiteA Translational Study of the ATR Inhibitor Berzosertib as Monotherapy in Four Molecularly Defined Cohorts of Advanced Solid Tumors.
Journal Article Clin Cancer Res · January 6, 2025 PURPOSE: Preclinical studies have identified molecular correlates of sensitivity to ATR inhibition. This translational study was designed to test the ATR inhibitor berzosertib in patients with advanced solid tumors carrying alterations in ATRX, ataxia-tela ... Full text Link to item CiteRegulation, functional impact, and therapeutic targeting of APOBEC3A in cancer.
Journal Article DNA repair · September 2024 Enzymes of the apolipoprotein B mRNA editing catalytic polypeptide like (APOBEC) family are cytosine deaminases that convert cytosine to uracil in DNA and RNA. Among these proteins, APOBEC3 sub-family members, APOBEC3A (A3A) and APOBEC3B (A3B), are promine ... Full text CiteRecent Grants
Mechanisms of APOBEC3A-induced cancer evolution and cancer vulnerability
ResearchPrincipal Investigator · Awarded by Massachusetts General Hospital · 2024 - 2029Understanding and targeting the DNA replication stress in cancer cells
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2023 - 2028ASPET SURF Institutional Award
Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by American Society for Pharmacology and Experimental Therapeutics · 2018 - 2028View All Grants
Education, Training & Certifications
Stony Brook University ·
1999
Ph.D.