Overview
Lesley H. Curtis is Chair and Professor in the Department of Population Health Sciences and Professor in Medicine in the Duke School of Medicine. A health services researcher by training, Dr. Curtis is an expert in the use of health care and Medicare claims data for health services and clinical outcomes research, and a leader in national data quality efforts. Dr. Curtis has led the linkage of Medicare claims with several large clinical registries and epidemiological cohort studies including the Framingham Heart Study and the Cardiovascular Health Study. Dr. Curtis recently served as a senior policy advisor at the Food and Drug Administration supporting the Agency’s evidence generation initiative, serves as an Investigator in the Coordinating Center for PCORI's PCORnet, and is co-PI of the NIH Pragmatic Trials Collaboratory, an NIH initiative to strengthen the national capacity for large-scale research studies embedded in health care delivery.
Areas of expertise: Health Services Research and Health Policy
Current Appointments & Affiliations
Recent Publications
Cardiovascular Statistics in the United States, 2026: JACC Stats.
Journal Article J Am Coll Cardiol · March 10, 2026 BACKGROUND: Cardiovascular disease remains the leading cause of morbidity and mortality in the United States. JACC Cardiovascular Statistics 2026 reports the most up-to-date data on cardiovascular health in the United States. The report covers major cardio ... Full text Link to item CiteOut-of-Pocket Costs and Financial Burden Among Working-Age Adults With Cardiovascular Conditions: A JACC Data Report on Trends in the United States, 2007-2022.
Journal Article J Am Coll Cardiol · March 10, 2026 Full text Link to item CiteHow PCORnet® Could Advance Postmarket Evidence Generation.
Journal Article Med Care · February 1, 2026 The PCORnet vision to accelerate progress towards a learning health system by enabling more efficient generation of evidence is shared by the US Food and Drug Administration, where we recently served. One way of achieving this goal is to develop national n ... Full text Link to item CiteRecent Grants
2/3 CTSA K12 Program at Duke University
ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030Nurse LEADS: Training in Nurse-LEd models of care ADdressing the Social Determinants of Health
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Nursing Research · 2024 - 2029NIH Health Care Systems Research Collaboratory-Coordinating Center (U24 Clinical Trial Not Allowed)
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2017 - 2028View All Grants