Scholars@Duke
Darrell Vincent Lewis Jr.

Darrell Vincent Lewis Jr.

Professor Emeritus of Pediatrics
Pediatrics, Neurology
lewis013@mc.duke.edu
Box 3936 Med Ctr, Durham, NC 27710
125 Bell Bldg, Durham, NC 27710

Featured Works

Hippocampal MRI signal hyperintensity after febrile status epilepticus is predictive of subsequent mesial temporal sclerosis.

Journal article AJR Am J Roentgenol · April 2008 Featured Work OBJECTIVE: The objective of our study was to test the hypothesis that the finding of hyperintense hippocampal signal intensity on T2-weighted MR images soon after febrile status epilepticus is associated with subsequent hippocampal volume loss and persiste ... Full text Link to item Cite

Effects of gamma hydroxybutyric acid on inhibition and excitation in rat neocortex.

Journal article Neuroscience · November 30, 2007 Featured Work The mechanism by which the sedative and amnestic recreational drug gamma hydroxybutyric acid (GHB) acts is controversial. Some studies indicate that it acts at its unique receptor, while others demonstrate effects mediated through the GABAB receptor. We ex ... Full text Link to item Cite

Losing neurons: selective vulnerability and mesial temporal sclerosis.

Journal article Epilepsia · 2005 Featured Work Mesial temporal sclerosis (MTS) is found in about two-thirds of patients with refractory temporal lobe epilepsy (TLE), and surgical removal of the sclerotic structures eliminates seizures in the majority of cases undergoing surgical resection. Although mul ... Full text Link to item Cite

NMDA receptor antagonists disinhibit rat posterior cingulate and retrosplenial cortices: a potential mechanism of neurotoxicity.

Journal article J Neurosci · April 15, 2002 Featured Work NMDA receptor antagonists produce region-specific neurodegeneration by an undetermined mechanism, but one proposed mechanism involves disinhibition. In certain areas of the brain, NMDA receptors mediate excitatory drive onto inhibitory interneurons. Thus, ... Full text Link to item Cite

Do prolonged febrile seizures produce medial temporal sclerosis? Hypotheses, MRI evidence and unanswered questions.

Journal article Prog Brain Res · 2002 Featured Work Whether or not severe febrile seizures in infancy cause hippocampal injury and subsequent medial temporal sclerosis is an often debated question in epilepsy. Recent magnetic resonance imaging (MRI) of infants suffering from febrile seizures has provided pr ... Full text Link to item Cite

Human herpesvirus 6 limbic encephalitis after stem cell transplantation.

Journal article Ann Neurol · November 2001 Featured Work Central nervous system complications are common in stem cell transplant recipients, but selective involvement of the medial temporal area is unusual. The 5 patients reported here presented after stem cell transplantation with increased hippocampal T2 signa ... Full text Link to item Cite

Seizure outcome after temporal lobectomy for temporal lobe epilepsy: a Kaplan-Meier survival analysis.

Journal article Neurology · February 8, 2000 Featured Work OBJECTIVE: To determine seizure outcome and its predictors in patients with medically refractory temporal lobe epilepsy (TLE) after temporal lobectomy (TL). BACKGROUND: TL is the most common surgical procedure performed in adolescents and adults for the tr ... Full text Link to item Cite

GABAB-Receptor-mediated currents in interneurons of the dentate-hilus border.

Journal article J Neurophysiol · September 1999 Featured Work GABA(B)-receptor-mediated inhibition was investigated in anatomically identified inhibitory interneurons located at the border between the dentate gyrus granule cell layer and hilus. Biocytin staining was used to visualize the morphology of recorded cells. ... Full text Link to item Cite