Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Research Scientist, Surgery, Duke University 2003 - 2010
  • Research Associate, Chemistry, Vanderbilt University 2000 - 2001
  • Postdoctoral Fellow, Microbiology And Immunoloty, Vanderbilt University 1998 - 2000
  • Ph.D., University of North Carolina - Chapel Hill 1994
• 

  Previous Appointments & Affiliations

  • Assistant Professor of Surgery, Surgery, Surgical Sciences, Surgery 2010 - 2020
• 

  Academic Positions Outside Duke

  • Instructor, Meharry Medical College. 2002 - 2003
  • Associate Director, Meharry Medical College. 2001 - 2002
• Research
• 

  Selected Grants

  • New Non-Nuceleotide Reverse Transcriptase Inhibitors for Drug Resistant HIV Strains awarded by National Institutes of Health 2021 - 2024
  • Small Molecule HIV-1 Entry Inhibitor with Novel Mechanisms of Action awarded by National Institutes of Health 2018 - 2021
  • Aloperine derivatives as novel anti-influenza agents awarded by National Institutes of Health 2020 - 2021
  • Plant Anti-HIV Agents awarded by University of North Carolina - Chapel Hill 2009 - 2020
  • Gnidimacrin and its derivatives against HIV-1 latency awarded by CRDF Global 2018 - 2019
  • Quinolizidines as Novel HIV-1 Entry Inhibitors awarded by National Institutes of Health 2016 - 2018
  • Regulation of PD-1 as a strategy against chronic HIV-1 infection awarded by National Institutes of Health 2013 - 2016
  • Betulinic acid derivatives as anti-HIV agents awarded by National Institutes of Health 2006 - 2016
  • Small Molecules that Regulate Proteasome Activity awarded by National Institutes of Health 2009 - 2013
  • Identification of anti-HIV agent(s) from Sophora Alkaloids awarded by National Institutes of Health 2008 - 2011
  • TM-SU Interaction in the Native HIV/SIV Env awarded by National Institutes of Health 2001 - 2008
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Asada, Yoshihisa, Kouharu Otsuki, Miki Morooka, Li Huang, Chin-Ho Chen, Kazuo Koike, and Wei Li. “Anti-HIV Macrocyclic Daphnane Orthoesters with an Unusual Macrocyclic Ring from Edgeworthia chrysantha.” J Nat Prod 85, no. 10 (October 28, 2022): 2399–2405. https://doi.org/10.1021/acs.jnatprod.2c00618.
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    • Huang, Li, Lei Zhu, Hua Xie, Jeffery Shawn Goodwin, Tanu Rana, Lan Xie, and Chin-Ho Chen. “Quinolizidines as Novel SARS-CoV-2 Entry Inhibitors.” Int J Mol Sci 23, no. 17 (August 25, 2022). https://doi.org/10.3390/ijms23179659.
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    • Zhou, Di, Kouharu Otsuki, Mi Zhang, Gang Chen, Zi-Song Bai, Haotian Yu, Takashi Kikuchi, et al. “Anti-HIV Tigliane-Type Diterpenoids from the Aerial Parts of Wikstroemia lichiangensis.” J Nat Prod 85, no. 6 (June 24, 2022): 1658–64. https://doi.org/10.1021/acs.jnatprod.1c01195.
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    • Otsuki, Kouharu, Mi Zhang, Takashi Kikuchi, Minami Tsuji, Miyuko Tejima, Zi-Song Bai, Di Zhou, et al. “Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation.” J Nat Med 75, no. 4 (September 2021): 1058–66. https://doi.org/10.1007/s11418-021-01551-9.
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    • Dang, Zhao, Lei Zhu, Lan Xie, Kuo-Hsiung Lee, Faisal Malik, Zhijun Li, Li Huang, and Chin-Ho Chen. “Design and Synthesis of Quinolizidine Derivatives as Influenza Virus and HIV-1 Inhibitors.” Curr Med Chem 28, no. 24 (2021): 4995–5003. https://doi.org/10.2174/0929867328666201229121802.
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    • Otsuki, Kouharu, Mi Zhang, Asuka Yamamoto, Minami Tsuji, Miyuko Tejima, Zi-Song Bai, Di Zhou, et al. “Anti-HIV Tigliane Diterpenoids from Wikstroemia scytophylla.” J Nat Prod 83, no. 12 (December 24, 2020): 3584–90. https://doi.org/10.1021/acs.jnatprod.0c00700.
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    • Otsuki, Kouharu, Wei Li, Kasumi Miura, Yoshihisa Asada, Li Huang, Chin-Ho Chen, Kuo-Hsiung Lee, and Kazuo Koike. “Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora.” J Nat Prod 83, no. 11 (November 25, 2020): 3270–77. https://doi.org/10.1021/acs.jnatprod.0c00540.
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    • Liu, Qingbo, Yung-Yi Cheng, Wei Li, Li Huang, Yoshihisa Asada, Min-Tsang Hsieh, Susan L. Morris-Natschke, Chin-Ho Chen, Kazuo Koike, and Kuo-Hsiung Lee. “Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents.” J Med Chem 62, no. 15 (August 8, 2019): 6958–71. https://doi.org/10.1021/acs.jmedchem.9b00339.
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    • Wu, Haifeng, Guoxu Ma, Qinwen Yang, Yindi Zhu, Li Huang, Yu Tian, Xiaoming Yang, et al. “Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity.” Eur J Med Chem 166 (March 15, 2019): 159–66. https://doi.org/10.1016/j.ejmech.2019.01.020.
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    • Liu, Qingbo, Wei Li, Li Huang, Yoshihisa Asada, Susan L. Morris-Natschke, Chin-Ho Chen, Kuo-Hsiung Lee, and Kazuo Koike. “Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui.” Eur J Med Chem 156 (August 5, 2018): 618–27. https://doi.org/10.1016/j.ejmech.2018.07.020.
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    • Huang, Li, Wei-Hong Lai, Lei Zhu, Wei Li, Lei Wei, Kuo-Hsiung Lee, Lan Xie, and Chin-Ho Chen. “Elimination of HIV-1 Latently Infected Cells by Gnidimacrin and a Selective HDAC Inhibitor.” Acs Med Chem Lett 9, no. 3 (March 8, 2018): 268–73. https://doi.org/10.1021/acsmedchemlett.8b00012.
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    • Dang, Zhao, Hua Xie, Lei Zhu, Qingye Zhang, Zhijun Li, Li Huang, and Chin-Ho Chen. “Structure Optimization of Aloperine Derivatives as HIV-1 Entry Inhibitors.” Acs Med Chem Lett 8, no. 11 (November 9, 2017): 1199–1203. https://doi.org/10.1021/acsmedchemlett.7b00376.
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    • Wei, Lei, Hui-Ling Wang, Li Huang, Chin-Ho Chen, Susan L. Morris-Natschke, Kuo-Hsiung Lee, and Lan Xie. “Drug-like property-driven optimization of 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitors against rilpivirine-resistant mutant virus.” Bioorg Med Chem Lett 27, no. 12 (June 15, 2017): 2788–92. https://doi.org/10.1016/j.bmcl.2017.04.068.
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    • Thomsen, Alex R. B., Bianca Plouffe, Thomas J. Cahill, Arun K. Shukla, Jeffrey T. Tarrasch, Annie M. Dosey, Alem W. Kahsai, et al. “GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.” Cell 166, no. 4 (August 11, 2016): 907–19. https://doi.org/10.1016/j.cell.2016.07.004.
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    • Liu, Na, Lei Wei, Li Huang, Fei Yu, Weifan Zheng, Bingjie Qin, Dong-Qin Zhu, et al. “Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus.” J Med Chem 59, no. 8 (April 28, 2016): 3689–3704. https://doi.org/10.1021/acs.jmedchem.5b01827.
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    • Dang, Zhao, Lei Zhu, Weihong Lai, Hal Bogerd, Kuo-Hsiung Lee, Li Huang, and Chin-Ho Chen. “Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors.” Acs Med Chem Lett 7, no. 3 (March 10, 2016): 240–44. https://doi.org/10.1021/acsmedchemlett.5b00339.
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    • Ho, Meng-Hsuan, Li Huang, J Shawn Goodwin, Xinhong Dong, Chin-Ho Chen, and Hua Xie. “Two Small Molecules Block Oral Epithelial Cell Invasion by Porphyromons gingivalis.” Plos One 11, no. 2 (2016): e0149618. https://doi.org/10.1371/journal.pone.0149618.
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    • Li, Jizhen, Masuo Goto, Xiaoming Yang, Susan L. Morris-Natschke, Li Huang, Chin-Ho Chen, and Kuo-Hsiung Lee. “Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity.” Bioorg Med Chem Lett 26, no. 1 (January 1, 2016): 68–71. https://doi.org/10.1016/j.bmcl.2015.11.029.
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    • Lai, Weihong, Li Huang, Lei Zhu, Guido Ferrari, Cliburn Chan, Wei Li, Kuo-Hsiung Lee, and Chin-Ho Chen. “Gnidimacrin, a Potent Anti-HIV Diterpene, Can Eliminate Latent HIV-1 Ex Vivo by Activation of Protein Kinase C β.” J Med Chem 58, no. 21 (November 12, 2015): 8638–46. https://doi.org/10.1021/acs.jmedchem.5b01233.
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    • Xu, Kai, Ke Wang, Ying Yang, Ding-An Yan, Li Huang, Chin-Ho Chen, and Zhiyan Xiao. “Discovery of novel non-covalent inhibitors selective to the β5-subunit of the human 20S proteasome.” Eur J Med Chem 98 (June 15, 2015): 61–68. https://doi.org/10.1016/j.ejmech.2015.05.023.
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    • Dang, Zhao, Katherine Jung, Lei Zhu, Hua Xie, Kuo-Hsiung Lee, Chin-Ho Chen, and Li Huang. “Phenolic diterpenoid derivatives as anti-influenza a virus agents.” Acs Med Chem Lett 6, no. 3 (March 12, 2015): 355–58. https://doi.org/10.1021/ml500533x.
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    • Gao, Jiadi, Cheng Fang, Zhiyan Xiao, Li Huang, Chin-Ho Chen, Li-Ting Wang, and Kuo-Hsiung Lee. “Discovery of novel 5-fluoro-N2,N4-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9.” Medchemcomm 6, no. 3 (March 1, 2015): 444–54. https://doi.org/10.1039/C4MD00412D.
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    • Huang, Li, Katherine Jung, and Chin Ho Chen. “Inhibitory effect of b-AP15 on the 20S proteasome.” Biomolecules 4, no. 4 (October 14, 2014): 931–39. https://doi.org/10.3390/biom4040931.
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    • Dang, Zhao, Katherine Jung, Lei Zhu, Weihong Lai, Hua Xie, Kuo-Hsiung Lee, Li Huang, and Chin-Ho Chen. “Identification and synthesis of quinolizidines with anti-influenza a virus activity.” Acs Med Chem Lett 5, no. 8 (August 14, 2014): 942–46. https://doi.org/10.1021/ml500236n.
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    • Shukla, Arun K., Aashish Manglik, Andrew C. Kruse, Kunhong Xiao, Rosana I. Reis, Wei-Chou Tseng, Dean P. Staus, et al. “Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.” Nature 497, no. 7447 (May 2, 2013): 137–41. https://doi.org/10.1038/nature12120.
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    • Dang, Zhao, Phong Ho, Lei Zhu, Keduo Qian, Kuo-Hsiung Lee, Li Huang, and Chin-Ho Chen. “New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1.” J Med Chem 56, no. 5 (March 14, 2013): 2029–37. https://doi.org/10.1021/jm3016969.
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    • Qian, Keduo, Ibrahim D. Bori, Chin-Ho Chen, Li Huang, and Kuo-Hsiung Lee. “Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors.” J Med Chem 55, no. 18 (September 27, 2012): 8128–36. https://doi.org/10.1021/jm301040s.
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    • Sun, Lian-Qi, Lei Zhu, Keduo Qian, Bingjie Qin, Li Huang, Chin Ho Chen, Kuo-Hsiung Lee, and Lan Xie. “Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates.” J Med Chem 55, no. 16 (August 23, 2012): 7219–29. https://doi.org/10.1021/jm3007678.
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    • Dang, Zhao, Keduo Qian, Phong Ho, Lei Zhu, Kuo-Hsiung Lee, Li Huang, and Chin-Ho Chen. “Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants.” Bioorg Med Chem Lett 22, no. 16 (August 15, 2012): 5190–94. https://doi.org/10.1016/j.bmcl.2012.06.080.
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    • Xu, Kai, Zhiyan Xiao, Yan Bo Tang, Li Huang, Chin-Ho Chen, Emika Ohkoshi, and Kuo-Hsiung Lee. “Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors.” Bioorg Med Chem Lett 22, no. 8 (April 15, 2012): 2772–74. https://doi.org/10.1016/j.bmcl.2012.02.086.
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    • Sun, Lian-Qi, Bingjie Qin, Li Huang, Keduo Qian, Chin-Ho Chen, Kuo-Hsiung Lee, and Lan Xie. “Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors.” Bioorg Med Chem Lett 22, no. 7 (April 1, 2012): 2376–79. https://doi.org/10.1016/j.bmcl.2012.02.055.
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    • Dang, Zhao, Kathy Jung, Keduo Qian, Kuo-Hsiung Lee, Li Huang, and Chin-Ho Chen. “Synthesis of Lithocholic Acid Derivatives as Proteasome Regulators.” Acs Med Chem Lett 3, no. 11 (2012): 925–30. https://doi.org/10.1021/ml3001962.
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    • Zhou, Ting, Qian Shi, Chin-Ho Chen, Li Huang, Phong Ho, Susan L. Morris-Natschke, and Kuo-Hsiung Lee. “Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R,2R-dicamphanoyl-3,3-dimethyldihydropyrano-[2,3-c]xanthen-7(1H)-one (DCX) derivatives as novel anti-HIV agents.” Eur J Med Chem 47, no. 1 (January 2012): 86–96. https://doi.org/10.1016/j.ejmech.2011.10.025.
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    • Qian, Keduo, Sang-Yong Kim, Hsin-Yi Hung, Li Huang, Chin-Ho Chen, and Kuo-Hsiung Lee. “New betulinic acid derivatives as potent proteasome inhibitors.” Bioorg Med Chem Lett 21, no. 19 (October 1, 2011): 5944–47. https://doi.org/10.1016/j.bmcl.2011.07.072.
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    • Lai, Weihong, Li Huang, Phong Ho, David Montefiori, and Chin-Ho Chen. “The role of dynamin in HIV type 1 Env-mediated cell-cell fusion.” Aids Res Hum Retroviruses 27, no. 9 (September 2011): 1013–17. https://doi.org/10.1089/AID.2010.0259.
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    • Tang, Yan-Boi, Chuan-Ming Zhang, Cheng Fang, Chun Hu, Li Huang, Chin-Ho Chen, and Zhi-Yan Xiao. “[Design, synthesis and evaluation of novel 2H-1, 4-benzodiazepine-2-ones as inhibitors of HIV-1 transcription].” Yao Xue Xue Bao 46, no. 6 (June 2011): 688–94.
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    • Dang, Zhao, Andrew Lin, Phong Ho, Dominique Soroka, Kuo-Hsiung Lee, Li Huang, and Chin-Ho Chen. “Synthesis and proteasome inhibition of lithocholic acid derivatives.” Bioorg Med Chem Lett 21, no. 7 (April 1, 2011): 1926–28. https://doi.org/10.1016/j.bmcl.2011.02.041.
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    • Huang, Li, Phong Ho, Jie Yu, Lei Zhu, Kuo-Hsiung Lee, and Chin-Ho Chen. “Picomolar dichotomous activity of gnidimacrin against HIV-1.” Plos One 6, no. 10 (2011): e26677. https://doi.org/10.1371/journal.pone.0026677.
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    • Zhou, Ting, Qian Shi, Chin-Ho Chen, Hao Zhu, Li Huang, Phong Ho, and Kuo-Hsiung Lee. “Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure-activity relationships of novel dicamphanoyl-2',2'-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents.” Bioorg Med Chem 18, no. 18 (September 15, 2010): 6678–89. https://doi.org/10.1016/j.bmc.2010.07.065.
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    • Qin, Bingjie, Xingkai Jiang, Hong Lu, Xingtao Tian, Florent Barbault, Li Huang, Keduo Qian, et al. “Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors.” J Med Chem 53, no. 13 (July 8, 2010): 4906–16. https://doi.org/10.1021/jm1002952.
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    • Qian, Keduo, Reen-Yun Kuo, Chin-Ho Chen, Li Huang, Susan L. Morris-Natschke, and Kuo-Hsiung Lee. “Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors.” J Med Chem 53, no. 8 (April 22, 2010): 3133–41. https://doi.org/10.1021/jm901782m.
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    • Lai, Wei-hong, Li Huang, and Chin-ho Chen. “HIV entry inhibitors: progress in development and application.” Yao Xue Xue Bao 45, no. 2 (February 2010): 131–40.
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    • Dang, Zhao, Weihong Lai, Keduo Qian, Phong Ho, Kuo-Hsiung Lee, Chin-Ho Chen, and Li Huang. “Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors.” J Med Chem 52, no. 23 (December 10, 2009): 7887–91. https://doi.org/10.1021/jm9004253.
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    • Dang, Z., L. Huang, and C. Chen. “HIV-1 maturation inhibitors: An update.” Drugs of the Future 34, no. 10 (October 1, 2009): 797–802. https://doi.org/10.1358/dof.2009.34.10.1428207.
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    • Qian, Keduo, Donglei Yu, Chin-Ho Chen, Li Huang, Susan L. Morris-Natschke, Theodore J. Nitz, Karl Salzwedel, Mary Reddick, Graham P. Allaway, and Kuo-Hsiung Lee. “Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents.” J Med Chem 52, no. 10 (May 28, 2009): 3248–58. https://doi.org/10.1021/jm900136j.
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    • Dang, Z., L. Huang, and C. H. Chen. “HIV-1 maturation inhibitors: An update.” Drugs of the Future 34, no. 10 (January 1, 2009): 797–802. https://doi.org/10.1358/dof.2009.034.10.1428207.
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    • Huang, Li, and Chin Ho Chen. “Proteasome regulators: activators and inhibitors.” Curr Med Chem 16, no. 8 (2009): 931–39. https://doi.org/10.2174/092986709787581860.
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    • Huang, Li, Donglei Yu, Phong Ho, Keduo Qian, Kuo-Hsiung Lee, and Chin-Ho Chen. “Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives.” Bioorg Med Chem 16, no. 14 (July 15, 2008): 6696–6701. https://doi.org/10.1016/j.bmc.2008.05.078.
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    • Lai, Weihong, Li Huang, Phong Ho, Zhijun Li, David Montefiori, and Chin-Ho Chen. “Betulinic acid derivatives that target gp120 and inhibit multiple genetic subtypes of human immunodeficiency virus type 1.” Antimicrob Agents Chemother 52, no. 1 (January 2008): 128–36. https://doi.org/10.1128/AAC.00737-07.
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    • Huang, L., D. Yu, P. Ho, K. H. Lee, and C. H. Chen. “Synthesis and anti-HIV activity of Bif-functional triterpene derivatives.” Letters in Drug Design and Discovery 4, no. 7 (October 1, 2007): 471–78. https://doi.org/10.2174/157018007781788561.
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    • Huang, Li, Weihong Lai, Phong Ho, and Chin Ho Chen. “Induction of a nonproductive conformational change in gp120 by a small molecule HIV type 1 entry inhibitor.” Aids Res Hum Retroviruses 23, no. 1 (January 2007): 28–32. https://doi.org/10.1089/aid.2006.0137.
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    • Yu, Donglei, Yojiro Sakurai, Chin-Ho Chen, Fang-Rong Chang, Li Huang, Yoshiki Kashiwada, and Kuo-Hsiung Lee. “Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents.” J Med Chem 49, no. 18 (September 7, 2006): 5462–69. https://doi.org/10.1021/jm0601912.
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    • Huang, Li, Phong Ho, Kuo-Hsiung Lee, and Chin-Ho Chen. “Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives.” Bioorg Med Chem 14, no. 7 (April 1, 2006): 2279–89. https://doi.org/10.1016/j.bmc.2005.11.016.
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    • Zhou, Jing, Li Huang, David L. Hachey, Chin Ho Chen, and Christopher Aiken. “Inhibition of HIV-1 maturation via drug association with the viral Gag protein in immature HIV-1 particles.” J Biol Chem 280, no. 51 (December 23, 2005): 42149–55. https://doi.org/10.1074/jbc.M508951200.
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    • Huang, Li, Xiong Yuan, Donglei Yu, K. H. Lee, and Chin Ho Chen. “Mechanism of action and resistant profile of anti-HIV-1 coumarin derivatives.” Virology 332, no. 2 (February 20, 2005): 623–28. https://doi.org/10.1016/j.virol.2004.11.033.
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    • Huang, L., and C. H. Chen. “The molecular targets of anti-HIV-1 triterpenes, an update.” Medicinal Chemistry Reviews  Online 2, no. 5 (January 1, 2005): 423–27. https://doi.org/10.2174/156720305774330449.
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    • Yuan, Xiong, Li Huang, Phong Ho, Celia Labranche, and Chin Ho Chen. “Conformation of gp120 determines the sensitivity of HIV-1 DH012 to the entry inhibitor IC9564.” Virology 324, no. 2 (July 1, 2004): 525–30. https://doi.org/10.1016/j.virol.2004.04.009.
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    • Huang, Li, Xiong Yuan, Christopher Aiken, and Chin Ho Chen. “Bifunctional anti-human immunodeficiency virus type 1 small molecules with two novel mechanisms of action.” Antimicrob Agents Chemother 48, no. 2 (February 2004): 663–65. https://doi.org/10.1128/AAC.48.2.663-665.2004.
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    • Huang, Li, Linda Zhang, and Chin Ho Chen. “Potential drug targets on the HIV-1 envelope glycoproteins, gp120 and gp41.” Curr Pharm Des 9, no. 18 (2003): 1453–62. https://doi.org/10.2174/1381612033454720.
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    • Li, Zhijun, Li Huang, Prasad Dande, Barry Gold, and Michael P. Stone. “Structure of a tethered cationic 3-aminopropyl chain incorporated into an oligodeoxynucleotide: evidence for 3'-orientation in the major groove accompanied by DNA bending.” J Am Chem Soc 124, no. 29 (July 24, 2002): 8553–60. https://doi.org/10.1021/ja0201707.
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    • Huang, Li, and Chin Ho Chen. “Molecular targets of anti-HIV-1 triterpenes.” Curr Drug Targets Infect Disord 2, no. 1 (March 2002): 33–36. https://doi.org/10.2174/1568005024605936.
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    • Huang, Li, Monroe E. Wall, Mansukh C. Wani, Hernán Navarro, Thawatchai Santisuk, Vichai Reutrakul, Eun-Kyoung Seo, Norman R. Farnsworth, and A Douglas Kinghorn. “New Compounds with DNA Strand-Scission Activity from the Combined Leaf and Stem ofUvaria hamiltonii.” Journal of Natural Products 61, no. 4 (April 1, 1998): 446–50. https://doi.org/10.1021/np9703609.
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    • Huang, L., F. Fullas, R. J. McGivney, D. M. Brown, and M. C. Wani. “A new prenylated flavonol from the root of Petalostemon purpureus.” Journal of Natural Products 59, no. 3 (1996): 290–92.
    • Chaudhuri, S. K., L. Huang, F. Fullas, D. M. Brown, and M. C. Wani. “Isolation and structure identification of an active DNA strand-scission agent, (+)-3,4-di-hydroxy-8,9-methylenedioxypterocarpan.” Journal of Natural Products 58, no. 12 (1995): 1966–69.
    • Huang, L., Y. Kashiwada, L. M. Cosentino, S. Fan, C. H. Chen, A. T. McPhail, T. Fujioka, K. Mihashi, and K. H. Lee. “Anti-AIDS agents. 15. Synthesis and anti-HIV activity of dihydroseselins and related analogs.” J Med Chem 37, no. 23 (November 11, 1994): 3947–55. https://doi.org/10.1021/jm00049a014.
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    • Lee, T. T., Y. Kashiwada, L. Huang, J. Snider, M. Cosentino, and K. H. Lee. “Suksdorfin: an anti-HIV principle from Lomatium suksdorfii, its structure-activity correlation with related coumarins, and synergistic effects with anti-AIDS nucleosides.” Bioorg Med Chem 2, no. 10 (October 1994): 1051–56. https://doi.org/10.1016/s0968-0896(00)82054-4.
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    • Huang, L., Y. Kashiwada, L. M. Cosentino, S. Fan, and K. H. Lee. “3′,4′-Di-o-(-)-camphanoyl-(+)-ciskhellactone and related compounds: A. new class of potent anti-HIV agents.” Bioorganic and Medicinal Chemistry Letters 4, no. 4 (February 24, 1994): 593–98. https://doi.org/10.1016/S0960-894X(01)80161-X.
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    • Kashiwada, Y., L. Huang, L. M. Ballas, J. B. Jiang, W. P. Janzen, and K. H. Lee. “New hexahydroxybiphenyl derivatives as inhibitors of protein kinase C.” J Med Chem 37, no. 1 (January 7, 1994): 195–200. https://doi.org/10.1021/jm00027a025.
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    • Kashiwada, Y., L. Huang, R. E. Kilkuskie, A. J. Bodner, and K. H. Lee. “New hexahydroxydiphenyl derivatives as potent inhibitors of HIV replication in H9 lymphocytes.” Bioorganic and Medicinal Chemistry Letters 2, no. 3 (January 1, 1992): 235–38. https://doi.org/10.1016/S0960-894X(01)81071-4.
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  • Conference Papers

    • Huang, L., W. Lai, L. Zhu, and C. -. H. Chen. “Elimination of HIV-1 latently infected cells by PKC agonist gnidimacrin alone and in combination with a histone deacetylase inhibitor.” In Journal of the International Aids Society, Vol. 19. JOHN WILEY & SONS LTD, 2016.
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    • Zhou, Ting, Chin-Ho Chen, Qian Shi, Li Huang, Phong Ho, and Kuo-Hsiung Lee. “Design, synthesis and structure-activity relationships of novel dicamphanoyl-2 ',2 '-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents.” In Abstracts of Papers of the American Chemical Society, Vol. 240. AMER CHEMICAL SOC, 2010.
       Link to Item
    • Lai, Weihong, Li Huang, Phong Ho, Xiong Yuan, and Chin-Ho Chen. “Inhibition of HIV-1 Entry by Inducing a Nonproductive Conformational Change in gp120.” In Retrovirology, Vol. 2. Springer Science and Business Media LLC, 2005. https://doi.org/10.1186/1742-4690-2-s1-p54.
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• Scholarly, Clinical, & Service Activities
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  Presentations & Appearances

  • Elimination of HIV-1 latently infected cells by PKC agonist gnidimacrin alone and in combination with an HDAC inhibitor. 21st International AIDS Conference (AIDS 2016). July 2016  2016

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