Scholars@Duke
Li Lan

Li Lan

Associate Professor of Molecular Genetics and Microbiology
Molecular Genetics and Microbiology
li.lan@duke.edu
424 CARL, Box 3054, Durham, NC 27710
424 CARL BX3054, 213 Reserch Drive, Durham, NC 27710

Scholarly Works - Conferences

Abstract 1751: Deletion of the DACH1 gene tumor suppressor increases replication fork stress, epithelial mesenchymal transition and sensitivity to WEE1 kinase inhibitors in prostate cancer

Conference Cancer Research · April 3, 2026 Abstract• Introduction: Patients with metastatic prostate cancer have poor survival with DNA damage repair pathway abnormalities. The cell fate determination factor DACH1 is deleted (shallow or deep delet ... Full text Cite

Abstract PR001: Targeting mRNA methyltransferase in RNA-dependent DNA repair in cancer therapy

Conference Molecular Cancer Therapeutics · November 14, 2024 AbstractThe treatment of many solid tumors presents significant challenges with chemotherapy, radiation therapy, and the limited effectiveness of immunotherapy. Targeted therapy offers a promising approach, ... Full text Cite

Abstract 5581: The DACH1 gene, frequently co-deleted with BRCA2 in prostate cancer, governs PARP inhibitor resistance

Conference Cancer Research · March 22, 2024 AbstractBackground: Prostate cancer (PCa), the second leading cause of death in American men, includes distinct genetic subtypes with distinct therapeutic vulnerabilities (1,2). The DACH1 gene, in the 13q21. ... Full text Cite

Abstract LB-162: Oxidative damage disrupts telomere integrity and leads to cell senescence

Conference Cancer Research · August 1, 2015 AbstractCellular DNA is organized into chromosomes and capped by a unique nucleoprotein structure, the telomere. Both oxidative stress and telomere shortening/dysfunction cause aging-related degenerative pat ... Full text Cite