Qiang Li | Scholars@Duke

Qiang Li
Adjunct Associate Professor in the Department of Radiology

Dr. Qiang Li's research interests include the development and evaluation of computer-aided diagnostic systems for lung cancer and interstitial lung disease in chest radiography and thracic CT, brain tumor in MRI, and intracranial aneurysm in MR angiography. He and his colleagues developed selective filter for enhancement of lesions and suppression of normal structures in 2D and 3D images, 3D algorithm for accurate segmentation of lung cancer and brain tumor using a spiral-scanning technique, automated rule-based classifier with high performance and minimized over-training effect, temporal subtraction of sequential images for enhancement of interval changes of lesions in chest radiography and whole-body bone scan, and contralateral subtraction for enhancement of asymmetric lesions in chest radiography. He also conducted a series of quality researches in the evaluation of CAD systems, including development of methods for reducing bias and variance in the estimated performance, development of guidelines for selecting appropriate evaluation methods in typical situations, and development of methods to improve CAD's generalizability for new cases.

Current Appointments & Affiliations

Adjunct Associate Professor in the Department of Radiology, Radiology, Clinical Science Departments 2012

Contact Information

2424 Erwin Rd Ste 302, Box 2731 Med Ctr, Durham, NC 27710
li.qiang@duke.edu (919) 684-1474

Background
Education, Training, & Certifications
- Ph.D., Kyoto University (Japan) 1998
Duke Appointment History
- Associate Professor of Radiology, Radiology, Clinical Science Departments 2008 - 2012
- Instructor, Temporary in the Department of Radiology, Radiology, Clinical Science Departments 2008
Research
Selected Grants
- CAD Lung Cancer Detection and Classification in CT awarded by National Institutes of Health 2006 - 2010
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Wang, J, Li, F, Doi, K, and Li, Q. "Computerized detection of diffuse lung disease in MDCT: the usefulness of statistical texture features." Phys Med Biol 54, no. 22 (November 21, 2009): 6881-6899. Full Text Link to Item
  - Wang, J, Li, F, and Li, Q. "Automated segmentation of lungs with severe interstitial lung disease in CT." Medical Physics 36, no. 10 (October 2009): 4592-4599. Full Text
  - Song, E, Jiang, L, Jin, R, Zhang, L, Yuan, Y, and Li, Q. "Breast mass segmentation in mammography using plane fitting and dynamic programming." Academic Radiology 16, no. 7 (July 2009): 826-835. Full Text
  - Li, F, Kumazawa, S, Shiraishi, J, Li, Q, Engelmann, R, Caligiuri, P, MacMahon, H, and Doi, K. "Subjective similarity of patterns of diffuse interstitial lung disease on thin-section CT: an observer performance study." Acad Radiol 16, no. 4 (April 2009): 477-485. Full Text Link to Item
  - Muramatsu, C, Li, Q, Schmidt, RA, Shiraishi, J, and Doi, K. "Determination of similarity measures for pairs of mass lesions on mammograms by use of BI-RADS lesion descriptors and image features." Acad Radiol 16, no. 4 (April 2009): 443-449. Full Text Link to Item
  - Muramatsu, C, Li, Q, Schmidt, R, Shiraishi, J, and Doi, K. "Investigation of psychophysical similarity measures for selection of similar images in the diagnosis of clustered microcalcifications on mammograms." Med Phys 35, no. 12 (December 2008): 5695-5702. Full Text Link to Item
  - Kumazawa, S, Muramatsu, C, Li, Q, Li, F, Shiraishi, J, Caligiuri, P, Schmidt, RA, MacMahon, H, and Doi, K. "An investigation of radiologists' perception of lesion similarity: observations with paired breast masses on mammograms and paired lung nodules on CT images." Acad Radiol 15, no. 7 (July 2008): 887-894. Full Text Link to Item
  - Li, Q, Li, F, and Doi, K. "Computerized detection of lung nodules in thin-section CT images by use of selective enhancement filters and an automated rule-based classifier." Acad Radiol 15, no. 2 (February 2008): 165-175. Full Text Link to Item
  - Wang, J, Engelmann, R, and Li, Q. "Segmentation of pulmonary nodules in three-dimensional CT images by use of a spiral-scanning technique." Med Phys 34, no. 12 (December 2007): 4678-4689. Full Text Link to Item
  - Li, Q. "Reliable evaluation of performance level for computer-aided diagnostic scheme." Acad Radiol 14, no. 8 (August 2007): 985-991. Full Text Link to Item
  - Shiraishi, J, Appelbaum, D, Pu, Y, Li, Q, Pesce, L, and Doi, K. "Usefulness of temporal subtraction images for identification of interval changes in successive whole-body bone scans: JAFROC analysis of radiologists' performance." Acad Radiol 14, no. 8 (August 2007): 959-966. Full Text Link to Item
  - Muramatsu, C, Li, Q, Schmidt, RA, Shiraishi, J, Suzuki, K, Newstead, GM, and Doi, K. "Determination of subjective similarity for pairs of masses and pairs of clustered microcalcifications on mammograms: comparison of similarity ranking scores and absolute similarity ratings." Med Phys 34, no. 7 (July 2007): 2890-2895. Full Text Link to Item
  - Li, Q. "Recent progress in computer-aided diagnosis of lung nodules on thin-section CT." Comput Med Imaging Graph 31, no. 4-5 (June 2007): 248-257. (Review) Full Text Link to Item
  - Li, Q. "Improvement of bias and generalizability for computer-aided diagnostic schemes." Comput Med Imaging Graph 31, no. 4-5 (June 2007): 338-345. Full Text Link to Item
  - Li, Q, and Doi, K. "Comparison of typical evaluation methods for computer-aided diagnostic schemes: Monte Carlo simulation study." Med Phys 34, no. 3 (March 2007): 871-876. Full Text Link to Item
  - Shiraishi, J, Li, Q, Appelbaum, D, Pu, Y, and Doi, K. "Development of a computer-aided diagnostic scheme for detection of interval changes in successive whole-body bone scans." Med Phys 34, no. 1 (January 2007): 25-36. Full Text Link to Item
  - Kasai, S, Li, F, Shiraishi, J, Li, Q, and Doi, K. "Computerized detection of vertebral compression fractures on lateral chest radiographs: preliminary results with a tool for early detection of osteoporosis." Med Phys 33, no. 12 (December 2006): 4664-4674. Full Text Link to Item
  - Muramatsu, C, Li, Q, Schmidt, R, Suzuki, K, Shiraishi, J, Newstead, G, and Doi, K. "Experimental determination of subjective similarity for pairs of clustered microcalcifications on mammograms: observer study results." Med Phys 33, no. 9 (September 2006): 3460-3468. Full Text Link to Item
  - Nakayama, Y, Li, Q, Katsuragawa, S, Ikeda, R, Hiai, Y, Awai, K, Kusunoki, S, Yamashita, Y, Okajima, H, Inomata, Y, and Doi, K. "Automated hepatic volumetry for living related liver transplantation at multisection CT." Radiology 240, no. 3 (September 2006): 743-748. Full Text
  - Li, F, Li, Q, Engelmann, R, Aoyama, M, Sone, S, MacMahon, H, and Doi, K. "Improving radiologists' recommendations with computer-aided diagnosis for management of small nodules detected by CT." Acad Radiol 13, no. 8 (August 2006): 943-950. Full Text Link to Item
  - Nie, Y, Li, Q, Li, F, Pu, Y, Appelbaum, D, and Doi, K. "Integrating PET and CT information to improve diagnostic accuracy for lung nodules: A semiautomatic computer-aided method." J Nucl Med 47, no. 7 (July 2006): 1075-1080. Link to Item
  - Shiraishi, J, Li, Q, Suzuki, K, Engelmann, R, and Doi, K. "Computer-aided diagnostic scheme for the detection of lung nodules on chest radiographs: localized search method based on anatomical classification." Med Phys 33, no. 7 (July 2006): 2642-2653. Full Text Link to Item
  - Li, Q, and Doi, K. "Reduction of bias and variance for evaluation of computer-aided diagnostic schemes." Med Phys 33, no. 4 (April 2006): 868-875. Full Text Link to Item
  - Arimura, H, Li, Q, Korogi, Y, Hirai, T, Katsuragawa, S, Yamashita, Y, Tsuchiya, K, and Doi, K. "Computerized detection of intracranial aneurysms for three-dimensional MR angiography: feature extraction of small protrusions based on a shape-based difference image technique." Med Phys 33, no. 2 (February 2006): 394-401. Full Text Link to Item
  - Li, Q, and Doi, K. "Analysis and minimization of overtraining effect in rule-based classifiers for computer-aided diagnosis." Med Phys 33, no. 2 (February 2006): 320-328. Full Text Link to Item
  - Li, F, Arimura, H, Suzuki, K, Shiraishi, J, Li, Q, Abe, H, Engelmann, R, Sone, S, MacMahon, H, and Doi, K. "Computer-aided detection of peripheral lung cancers missed at CT: ROC analyses without and with localization." Radiology 237, no. 2 (November 2005): 684-690. Full Text
  - Li, Q, Li, F, Suzuki, K, Shiraishi, J, Abe, H, Engelmann, R, Nie, Y, MacMahon, H, and Doi, K. "Computer-aided diagnosis in thoracic CT." Semin Ultrasound CT MR 26, no. 5 (October 2005): 357-363. (Review) Link to Item
  - Muramatsu, C, Li, Q, Suzuki, K, Schmidt, RA, Shiraishi, J, Newstead, GM, and Doi, K. "Investigation of psychophysical measure for evaluation of similar images for mammographic masses: preliminary results." Med Phys 32, no. 7 (July 2005): 2295-2304. Full Text Link to Item
  - Li, F, Aoyama, M, Shiraishi, J, Abe, H, Li, Q, Suzuki, K, Engelmann, R, Sone, S, Macmahon, H, and Doi, K. "Radiologists' performance for differentiating benign from malignant lung nodules on high-resolution CT using computer-estimated likelihood of malignancy." AJR Am J Roentgenol 183, no. 5 (November 2004): 1209-1215. Full Text Link to Item
  - Abe, H, Macmahon, H, Shiraishi, J, Li, Q, Engelmann, R, and Doi, K. "Computer-aided diagnosis in chest radiology." Semin Ultrasound CT MR 25, no. 5 (October 2004): 432-437. (Review) Link to Item
  - Arimura, H, Li, Q, Korogi, Y, Hirai, T, Abe, H, Yamashita, Y, Katsuragawa, S, Ikeda, R, and Doi, K. "Automated computerized scheme for detection of unruptured intracranial aneurysms in three-dimensional magnetic resonance angiography." Academic Radiology 11, no. 10 (October 2004): 1093-1104. Full Text
  - Li, Q, Li, F, Shiraishi, J, Katsuragawa, S, Sone, S, and Doi, K. "Investigation of new psychophysical measures for evaluation of similar images on thoracic computed tomography for distinction between benign and malignant nodules." Med Phys 30, no. 10 (October 2003): 2584-2593. Full Text Link to Item
  - Uchiyama, Y, Katsuragawa, S, Abe, H, Shiraishi, J, Li, F, Li, Q, Zhang, C-T, Suzuki, K, and Doi, K. "Quantitative computerized analysis of diffuse lung disease in high-resolution computed tomography." Med Phys 30, no. 9 (September 2003): 2440-2454. Full Text Link to Item
  - Li, Q, Sone, S, and Doi, K. "Selective enhancement filters for nodules, vessels, and airway walls in two- and three-dimensional CT scans." Med Phys 30, no. 8 (August 2003): 2040-2051. Full Text Link to Item
  - Shimosegawa, M, Aoyama, M, Li, Q, Abe, H, Li, F, Shiraishi, J, and Doi, K. "[Report on the 88th Scientific Assembly and Annual Meeting of the Radiological Society of North America: development of an image processing scheme for chest radiographs by using a dot printer]." Nihon Hoshasen Gijutsu Gakkai Zasshi 59, no. 5 (May 2003): 619-620. Link to Item
  - Aoyama, M, Li, Q, Katsuragawa, S, Li, F, Sone, S, and Doi, K. "Computerized scheme for determination of the likelihood measure of malignancy for pulmonary nodules on low-dose CT images." Med Phys 30, no. 3 (March 2003): 387-394. Full Text Link to Item
  - Abe, H, MacMahon, H, Engelmann, R, Li, Q, Shiraishi, J, Katsuragawa, S, Aoyama, M, Ishida, T, Ashizawa, K, Metz, CE, and Doi, K. "Computer-aided diagnosis in chest radiography: results of large-scale observer tests at the 1996-2001 RSNA scientific assemblies." Radiographics : a Review Publication of the Radiological Society of North America, Inc 23, no. 1 (January 2003): 255-265. Full Text
  - Shimosegawa, M, Aoyama, M, Li, Q, Abe, H, Li, F, Shiraishi, J, and Doi, K. "[Development of an image processing scheme for chest radiographs using a dot printer]." Nihon Hoshasen Gijutsu Gakkai Zasshi 58, no. 9 (September 2002): 1268-1277. Link to Item
  - Arimura, H, Katsuragawa, S, Li, Q, Ishida, T, and Doi, K. "Development of a computerized method for identifying the posteroanterior and lateral views of chest radiographs by use of a template matching technique." Med Phys 29, no. 7 (July 2002): 1556-1561. Full Text Link to Item
  - Aoyama, M, Li, Q, Katsuragawa, S, MacMahon, H, and Doi, K. "Automated computerized scheme for distinction between benign and malignant solitary pulmonary nodules on chest images." Medical Physics 29, no. 5 (May 2002): 701-708. Full Text
  - Tsukuda, S, Heshiki, A, Katsuragawa, S, Li, Q, MacMahon, H, and Doi, K. "Detection of lung nodules on digital chest radiographs: potential usefulness of a new contralateral subtraction technique." Radiology 223, no. 1 (April 2002): 199-203. Full Text
  - Li, Q, Katsuragawa, S, and Doi, K. "Computer-aided diagnostic scheme for lung nodule detection in digital chest radiographs by use of a multiple-template matching technique." Med Phys 28, no. 10 (October 2001): 2070-2076. Full Text Link to Item
  - Li, Q, Katsuragawa, S, and Doi, K. "Improved contralateral subtraction images by use of elastic matching technique." Med Phys 27, no. 8 (August 2000): 1934-1942. Full Text Link to Item
  - Li, Q, Katsuragawa, S, Ishida, T, Yoshida, H, Tsukuda, S, MacMahon, H, and Doi, K. "Contralateral subtraction: a novel technique for detection of asymmetric abnormalities on digital chest radiographs." Med Phys 27, no. 1 (January 2000): 47-55. Full Text Link to Item
  - Katsuragawa, S, Tagashira, H, Li, Q, MacMahon, H, and Doi, K. "Comparison of the quality of temporal subtraction images obtained with manual and automated methods of digital chest radiography." Journal of Digital Imaging 12, no. 4 (November 1999): 166-172. Full Text

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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles