Recent Publications
Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin.
Journal Article Oncogene · March 2017 Evasion of apoptosis allows many cancers to resist chemotherapy. Apoptosis is mediated by the serial activation of caspase family proteins. These proteases are often activated upon the release of cytochrome c from the mitochondria, which is promoted by the ... Full text CiteMitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint.
Journal Article Cell cycle (Georgetown, Tex.) · January 2016 The spindle checkpoint prevents activation of the anaphase-promoting complex (APC/C) until all chromosomes are correctly attached to the mitotic spindle. Early in mitosis, the mitotic checkpoint complex (MCC) inactivates the APC/C by binding the APC/C acti ... Full text CiteFatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.
Journal Article Oncogene · June 2015 Blockade of fatty acid synthase (FASN), a key enzyme involved in de novo lipogenesis, results in robust death of ovarian cancer cells. However, known FASN inhibitors have proven to be poor therapeutic agents due to their ability to induce cachexia. Therefo ... Full text CiteRecent Grants
Control of caspase activation in apoptosis
ResearchAssistant Research Professor · Awarded by National Institutes of Health · 2007 - 2017Regulation of M phase exit
ResearchPostdoctoral Associate · Awarded by National Institutes of Health · 2009 - 2011View All Grants
Education, Training & Certifications
Nankai University (China) ·
2005
Ph.D.