Scholars@Duke

• Background
• 

  Duke Appointment History

  • Assistant Professor - Track V of Medicine, Medicine, Medical Oncology, Medicine 2013 - 2015
• Research
• 

  Selected Grants

  • Control of caspase activation in apoptosis awarded by National Institutes of Health 2007 - 2017
  • Regulation of M phase exit awarded by National Institutes of Health 2009 - 2011
• Publications & Artistic Works
• 

  Selected Publications

  • Conference Papers

    • Pan, JL, Bao, ZM, Li, JL, Zhang, LG, Wu, C, and Yu, YT. "Chitosan-Based Scaffolds for Hepatocyte Culture." 2005.  Full Text

  • Journal Articles

    • Matsuura, K, Huang, N-J, Cocce, K, Zhang, L, and Kornbluth, S. "Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin." Oncogene 36, no. 12 (March 2017): 1698-1706.  Full Text
    • Foss, KM, Robeson, AC, Kornbluth, S, and Zhang, L. "Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint." Cell cycle (Georgetown, Tex.) 15, no. 2 (January 2016): 225-233.  Full Text
    • Yang, C-S, Matsuura, K, Huang, N-J, Robeson, AC, Huang, B, Zhang, L, and Kornbluth, S. "Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death." Oncogene 34, no. 25 (June 2015): 3264-3272.  Full Text
    • Huang, B, Yang, C-S, Wojton, J, Huang, N-J, Chen, C, Soderblom, EJ, Zhang, L, and Kornbluth, S. "Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A)." The Journal of biological chemistry 289, no. 52 (December 2014): 35882-35890.  Full Text
    • Chen, C, Zhang, L, Huang, N-J, Huang, B, and Kornbluth, S. "Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11." Proceedings of the National Academy of Sciences of the United States of America 110, no. 51 (December 2, 2013): 20605-20610.  Full Text  Open Access Copy
    • Zhang, L, Huang, N-J, Chen, C, Tang, W, and Kornbluth, S. "Ubiquitylation of p53 by the APC/C inhibitor Trim39." Proc Natl Acad Sci U S A 109, no. 51 (December 18, 2012): 20931-20936.  Full Text  Open Access Copy  Link to Item
    • Huang, N-J, Zhang, L, Tang, W, Chen, C, Yang, C-S, and Kornbluth, S. "The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1." J Cell Biol 197, no. 3 (April 30, 2012): 361-367.  Full Text  Open Access Copy  Link to Item
    • Zhang, L, Widau, RC, Herring, BP, and Gallagher, PJ. "Delta-like 1-Lysine613 regulates notch signaling." Biochimica et biophysica acta 1813, no. 12 (December 2011): 2036-2043.  Full Text
    • Zhang, L, and Gallagher, PJ. "Mind bomb 1 regulation of cFLIP interactions." American journal of physiology. Cell physiology 297, no. 5 (November 2009): C1275-C1283.  Full Text
    • Zhang, L, Wang, C-Y, Yang, R, Shi, J, Fu, R, Chen, L, Klocker, H, and Zhang, J. "Real-time quantitative RT-PCR assay of prostate-specific antigen and prostate-specific membrane antigen in peripheral blood for detection of prostate cancer micrometastasis." Urologic Oncology: Seminars and Original Investigations 26, no. 6 (November 2008): 634-640.  Full Text
    • Zhang, L, Nephew, KP, and Gallagher, PJ. "Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes." The Journal of biological chemistry 282, no. 16 (April 2007): 11795-11804.  Full Text
    • Zhang, L, Shi, J, Feng, J, Klocker, H, Lee, C, and Zhang, J. "Type IV collagenase (matrix metalloproteinase-2 and -9) in prostate cancer." Prostate Cancer and Prostatic Diseases 7, no. 4 (December 2004): 327-332.  Full Text
    • Li, J, Pan, J, Zhang, L, Guo, X, and Yu, Y. "Culture of primary rat hepatocytes within porous chitosan scaffolds." Journal of Biomedical Materials Research 67A, no. 3 (December 1, 2003): 938-943.  Full Text
    • Li, J, Pan, J, Zhang, L, and Yu, Y. "Culture of hepatocytes on fructose-modified chitosan scaffolds." Biomaterials 24, no. 13 (June 2003): 2317-2322.  Full Text
    • Zhang, L, Pan, J, Li, J, Wu, W, and Yu, Y. "Studies on the Preparation of Chitosan Microcarriers Cross‐Linked by Oxidized Lactose and Culture of Primary Hepatocytes." Artificial Cells, Blood Substitutes, and Biotechnology 31, no. 3 (January 2003): 293-301.  Full Text

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