Scholars@Duke

• Background
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  Duke Appointment History

  • Assistant Professor - Track V of Medicine, Medicine, Medical Oncology, Medicine 2013 - 2015
• Research
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  Selected Grants

  • Control of caspase activation in apoptosis awarded by National Institutes of Health 2007 - 2017
  • Regulation of M phase exit awarded by National Institutes of Health 2009 - 2011
• Publications & Artistic Works
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  Selected Publications

  • Academic Articles

    • Matsuura, K., N. -. J. Huang, K. Cocce, L. Zhang, and S. Kornbluth. “Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin.” Oncogene 36, no. 12 (March 2017): 1698–1706. https://doi.org/10.1038/onc.2016.336.
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    • Foss, Kristen M., Alexander C. Robeson, Sally Kornbluth, and Liguo Zhang. “Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint.” Cell Cycle (Georgetown, Tex.) 15, no. 2 (January 2016): 225–33. https://doi.org/10.1080/15384101.2015.1121331.
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    • Yang, C. -. S., K. Matsuura, N. -. J. Huang, A. C. Robeson, B. Huang, L. Zhang, and S. Kornbluth. “Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death.” Oncogene 34, no. 25 (June 2015): 3264–72. https://doi.org/10.1038/onc.2014.271.
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    • Huang, Bofu, Chih-Sheng Yang, Jeffrey Wojton, Nai-Jia Huang, Chen Chen, Erik J. Soderblom, Liguo Zhang, and Sally Kornbluth. “Metabolic control of Ca2+/calmodulin-dependent protein kinase II (CaMKII)-mediated caspase-2 suppression by the B55β/protein phosphatase 2A (PP2A).” J Biol Chem 289, no. 52 (December 26, 2014): 35882–90. https://doi.org/10.1074/jbc.M114.585844.
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    • Chen, Chen, Liguo Zhang, Nai-Jia Huang, Bofu Huang, and Sally Kornbluth. “Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11.” Proceedings of the National Academy of Sciences of the United States of America 110, no. 51 (December 2, 2013): 20605–10. https://doi.org/10.1073/pnas.1306328110.
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    • Zhang, Liguo, Nai-Jia Huang, Chen Chen, Wanli Tang, and Sally Kornbluth. “Ubiquitylation of p53 by the APC/C inhibitor Trim39.” Proceedings of the National Academy of Sciences of the United States of America 109, no. 51 (December 4, 2012): 20931–36. https://doi.org/10.1073/pnas.1212047110.
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    • Huang, Nai-Jia, Liguo Zhang, Wanli Tang, Chen Chen, Chih-Sheng Yang, and Sally Kornbluth. “The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1.” The Journal of Cell Biology 197, no. 3 (April 23, 2012): 361–67. https://doi.org/10.1083/jcb.201111141.
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    • Zhang, Liguo, Ryan C. Widau, B Paul Herring, and Patricia J. Gallagher. “Delta-like 1-Lysine613 regulates notch signaling.” Biochimica Et Biophysica Acta 1813, no. 12 (December 2011): 2036–43. https://doi.org/10.1016/j.bbamcr.2011.08.019.
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    • Zhang, Liguo, and Patricia J. Gallagher. “Mind bomb 1 regulation of cFLIP interactions.” American Journal of Physiology. Cell Physiology 297, no. 5 (November 2009): C1275–83. https://doi.org/10.1152/ajpcell.00214.2009.
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    • Zhang, Liguo, Chun-Yu Wang, Rui Yang, Jiandang Shi, Rong Fu, Linfeng Chen, Helmut Klocker, and Ju Zhang. “Real-time quantitative RT-PCR assay of prostate-specific antigen and prostate-specific membrane antigen in peripheral blood for detection of prostate cancer micrometastasis.” Urologic Oncology 26, no. 6 (November 2008): 634–40. https://doi.org/10.1016/j.urolonc.2007.07.016.
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    • Zhang, Liguo, Kenneth P. Nephew, and Patricia J. Gallagher. “Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes.” The Journal of Biological Chemistry 282, no. 16 (April 2007): 11795–804. https://doi.org/10.1074/jbc.m610430200.
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    • Zhang, L., J. Shi, J. Feng, H. Klocker, C. Lee, and J. Zhang. “Type IV collagenase (matrix metalloproteinase-2 and -9) in prostate cancer.” Prostate Cancer and Prostatic Diseases 7, no. 4 (January 2004): 327–32. https://doi.org/10.1038/sj.pcan.4500750.
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    • Li, Jieliang, Jilun Pan, Liguo Zhang, Xinji Guo, and Yaoting Yu. “Culture of primary rat hepatocytes within porous chitosan scaffolds.” Journal of Biomedical Materials Research. Part A 67, no. 3 (December 2003): 938–43. https://doi.org/10.1002/jbm.a.10076.
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    • Zhang, Liguo, Jilun Pan, Jieliang Li, Wei Wu, and Yaoting Yu. “Studies on the preparation of chitosan microcarriers cross-linked by oxidized lactose and culture of primary hepatocytes.” Artificial Cells, Blood Substitutes, and Immobilization Biotechnology 31, no. 3 (August 2003): 293–301. https://doi.org/10.1081/bio-120023159.
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    • Li, Jieliang, Jilun Pan, Liguo Zhang, and Yaoting Yu. “Culture of hepatocytes on fructose-modified chitosan scaffolds.” Biomaterials 24, no. 13 (June 2003): 2317–22. https://doi.org/10.1016/s0142-9612(03)00048-6.
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  • Conference Papers

    • Pan, Ji Lun, Zhi Ming Bao, Ji Liang Li, Li Guo Zhang, Chen Wu, and Yao Ting Yu. “Chitosan-Based Scaffolds for Hepatocyte Culture.” In Key Engineering Materials, 288–289:91–96. Trans Tech Publications, Ltd., n.d. https://doi.org/10.4028/www.scientific.net/kem.288-289.91.
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