Scholars@Duke
Corinne Mary Linardic

Corinne Mary Linardic

Associate Professor of Pediatrics
Pediatrics, Hematology-Oncology
linar001@mc.duke.edu
Box 102382, DUMC, Durham, NC 27710
LSRC Bldg Rm B361F, Research Drive, Durham, NC 27710

Featured Works

FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma.

Journal article Clin Cancer Res · July 15, 2012 Featured Publication PURPOSE: Rhabdomyosarcoma (RMS) is a malignancy with features of skeletal muscle, and the most common soft tissue sarcoma of childhood. Survival for high-risk groups is approximately 30% at 5 years and there are no durable therapies tailored to its genetic ... Full text Link to item Cite

In vivo imaging of tumor-propagating cells, regional tumor heterogeneity, and dynamic cell movements in embryonal rhabdomyosarcoma.

Journal article Cancer Cell · May 15, 2012 Featured Publication Embryonal rhabdomyosarcoma (ERMS) is an aggressive pediatric sarcoma of muscle. Here, we show that ERMS-propagating potential is confined to myf5+ cells and can be visualized in live, fluorescent transgenic zebrafish. During early tumor growth, myf5+ ERMS ... Full text Link to item Cite

Embryonic signaling pathways and rhabdomyosarcoma: contributions to cancer development and opportunities for therapeutic targeting.

Journal article Sarcoma · 2012 Featured Publication Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and adolescence, accounting for approximately 7% of childhood cancers. Current therapies include nonspecific cytotoxic chemotherapy regimens, radiation therapy, and surgery; however, thes ... Full text Link to item Cite

Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis.

Journal article Clin Cancer Res · December 1, 2011 Featured Publication PURPOSE: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and remains refractory to combined-modality therapy in patients with high risk disease. In skeletal myogenesis, Notch signaling prevents muscle differentiation and promotes ... Full text Link to item Cite

Receptor tyrosine kinases as therapeutic targets in rhabdomyosarcoma.

Journal article Sarcoma · 2011 Featured Publication Rhabdomyosarcomas (RMSs) are the most common soft tissue sarcomas of childhood and adolescence. To date, there are no effective treatments that target the genetic abnormalities in RMS, and current treatment options for high-risk groups are not adequate. Ov ... Full text Link to item Cite

Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma.

Journal article Cancer Res · December 1, 2008 Featured Publication Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and adolescence. Despite advances in therapy, patients with a histologic variant of RMS known as alveolar (aRMS) have a 5-year survival rate of <30%. aRMS tissues exhibit a number o ... Full text Link to item Cite

PAX3-FOXO1 fusion gene in rhabdomyosarcoma.

Journal article Cancer Lett · October 18, 2008 Featured Publication Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood and adolescence. The predominant histologic variants of this disease are termed embryonal (eRMS) and alveolar (aRMS), based on their appearance under light microscopy. Of the two, a ... Full text Link to item Cite

Genetic modeling of Ras-induced human rhabdomyosarcoma.

Journal article Methods Enzymol · 2008 Featured Publication Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and adolescence. Historically, rhabdomyosarcoma has been studied by the manipulation of human cell lines derived from primary rhabdomyosarcoma tumor tissue adapted to grow in culture. Rec ... Full text Link to item Cite

The PAX3-FKHR fusion gene of rhabdomyosarcoma cooperates with loss of p16INK4A to promote bypass of cellular senescence.

Journal article Cancer Res · July 15, 2007 Featured Publication Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood and adolescence. Despite advances in therapy, patients with a histologic variant of rhabdomyosarcoma known as alveolar rhabdomyosarcoma (ARMS) have a 5-year survival of <30%. ARMS is char ... Full text Link to item Cite

A network of genetic events sufficient to convert normal human cells to a tumorigenic state.

Journal article Cancer Res · November 1, 2005 Featured Publication Although great progress has been made at identifying and characterizing individual genes involved in cancer, less is known about how the combination of such genes collaborate to form tumors in humans. To this end, we sought to genetically recreate tumorige ... Full text Link to item Cite

Genetic modeling of human rhabdomyosarcoma.

Journal article Cancer Res · June 1, 2005 Featured Publication Rhabdomyosarcoma, a malignancy showing features of skeletal muscle differentiation, is the most common soft tissue sarcoma of childhood. The identification of distinct clinical presentation patterns, histologic tumor types, and risk groups suggests that rh ... Full text Link to item Cite