Scholars@Duke
Lindsay Yount King

Lindsay Yount King

Associate Professor of Medicine
Medicine, Gastroenterology

Scholarly Works

Guidance for Timely Referral to Liver Transplantation.

Journal article Clin Gastroenterol Hepatol · July 2026 Morbidity and mortality from cirrhosis is increasing, and it is mainly driven by liver-associated decompensation. Liver transplantation (LT) is the only curative treatment for decompensated cirrhosis and selected liver-related complications and malignancie ... Full text Link to item Cite

Evolution of out-of-sequence liver allocation, 2019-2024.

Journal article Am J Transplant · June 2026 Allocation out-of-sequence (AOOS) refers to deviation from the match run order in deceased donor organ allocation and is intended for use in exceptional cases to expedite organ placement. Contemporary patterns of AOOS in liver transplantation are not well ... Full text Link to item Cite

Organ-specific differences in the epidemiology of cytomegalovirus infections in high-risk (cytomegalovirus donor seropositive, recipient seronegative) solid organ transplant recipients with prolonged follow-up: A 10-year experience.

Journal article Am J Transplant · March 26, 2026 Cytomegalovirus (CMV) causes significant morbidity in CMV donor seropositive/recipient seronegative (D+R-) solid organ transplant recipients, but organ-specific differences in CMV epidemiology and the utility of laboratory surveillance after prophylaxis (S ... Full text Link to item Cite

Assessing blood culture appropriateness in solid organ transplant recipients: a diagnostic stewardship approach.

Journal article Infect Control Hosp Epidemiol · December 2025 OBJECTIVE: Diagnostic stewardship of blood culture utilization is important to mitigate the risks associated with unnecessary culturing. Although blood culture algorithms have been studied previously, there is a lack of data on their application among soli ... Full text Open Access Link to item Cite

Recommendations to overcome barriers to transplant fellowship training: A report from the American Society of Transplantation Fellows Task Force.

Journal article Am J Transplant · August 2025 With the expansion of solid organ transplantation activities in the United States, there is a critical need for more transplant care providers and trainees to sustain and advance the field of transplantation. However, there has been a pending shortage of t ... Full text Link to item Cite

Transforming the logistics of liver transplantation with normothermic machine perfusion: Clinical impact versus cost.

Journal article Liver Transpl · June 1, 2025 Normothermic machine perfusion (NMP) facilitates the utilization of marginal liver allografts. It remains unknown whether clinical benefits offset additional costs in the real-world setting. We performed a comparison of outcomes and hospitalization costs f ... Full text Link to item Cite

Hepatitis C Nucleic Acid Test Positive (NAT+) Solid Organ Consent Rates Are Highest in Patients Listed for Liver Transplant and With an English Language Preference.

Journal article Clin Transplant · June 2025 BACKGROUND: Transplantation of hepatitis C virus (HCV) nucleic acid (NAT) positive organs is associated with shorter time to transplant and decreased risk of death on the waiting list. Treatment for HCV post-transplant is well-tolerated, successful, and le ... Full text Link to item Cite

Advances in the treatment of hepatocellular carcinoma: An overview of the current and evolving therapeutic landscape for clinicians.

Journal article CA Cancer J Clin · 2025 Hepatocellular carcinoma (HCC) is the sixth most common malignancy and the third leading cause of cancer-related death worldwide. Contemporary advances in systemic and locoregional therapies have led to changes in peer-reviewed guidelines regarding systemi ... Full text Link to item Cite

Risk Factors for Invasive Surgical Site Infections Among Adult Single Liver Transplant Recipients at Duke University Hospital in the Period 2015-2020.

Journal article Transplant Direct · December 2024 BACKGROUND: Invasive primary surgical site infections (IP-SSI) are a severe complication of liver transplant surgery. Identification of risk factors for IP-SSI is critical to IP-SSI prevention. METHODS: All adult single liver transplants performed at Duke ... Full text Open Access Link to item Cite

Pediatric liver transplant recipients are not just young adults: The importance of a structured health care transition program in adult transplant centers.

Journal article Liver Transpl · September 1, 2024 Health care transition (HCT) is a vulnerable period that continues into adulthood, even after the transfer of care. Given the growing population of pediatric liver transplant recipients reaching young adulthood, the need for a standardized and multidiscipl ... Full text Link to item Cite

Adult provider role in transition of care for young adult pediatric recipients of liver transplant: An expert position statement.

Journal article Hepatol Commun · August 1, 2024 Health care transition (HCT) is the process of changing from a pediatric to an adult model of care. Young adult pediatric recipients of liver transplant transferring from pediatric to adult health care services are highly vulnerable and subject to poor lon ... Full text Link to item Cite

The Crucial Role of Empowerment in Engaging Adolescents and Young Adults for Independence: Essential Strategies and Skills for a Successful Transition.

Journal article Pediatr Transplant · August 2024 BACKGROUND: An increasing number of pediatric solid organ transplant (SOT) recipients are surviving into adolescence and young adulthood. The transition from pediatric to adult-oriented care occurs during a unique and vulnerable period. METHODS: Presented ... Full text Link to item Cite

Limitations of antifungal prophylaxis in preventing invasive Candida surgical site infections after liver transplant surgery.

Journal article Antimicrob Agents Chemother · March 6, 2024 Invasive primary Candida surgical site infections (IP-SSIs) are a common complication of liver transplantation, and targeted antifungal prophylaxis is an efficient strategy to limit their occurrence. We performed a retrospective single-center cohort study ... Full text Link to item Cite

Post-Transplant Management and Complications of Autoimmune Hepatitis, Primary Biliary Cholangitis, and Primary Sclerosing Cholangitis including Disease Recurrence.

Journal article Clin Liver Dis · February 2024 Autoimmune liver diseases have unique post-transplant considerations. These recipients are at increased risk of rejection, and recurrent disease may also develop, which can progress to graft loss and increase mortality. Monitoring for and managing these co ... Full text Link to item Cite

Real-world Experiences in the Transplantation of Hepatitis C-NAAT-positive Organs.

Journal article Transplant Direct · November 2023 BACKGROUND: Hepatitis C virus (HCV) nucleic acid amplification test (NAAT)-positive donors have increased the organ pool. Direct-acting antivirals (DAAs) have led to high rates of treatment success and sustained virologic response (SVR) in recipients with ... Full text Link to item Cite

Current approach to health care transition and integration into adult care for pediatric liver transplant recipients: A call for partnership.

Conference Clin Transplant · August 2023 Despite the increased risk of non-adherence, allograft rejection, and mortality following transfer from pediatric to adult care in liver transplantation (LT), there is no standardized approach to health care transition (HCT). Two electronic national survey ... Full text Link to item Cite

Impact of Pruritus on Quality of Life and Current Treatment Patterns in Patients with Primary Biliary Cholangitis.

Journal article Dig Dis Sci · March 2023 BACKGROUND AND AIMS: Patients with primary biliary cholangitis (PBC) often suffer with pruritus. We describe the impact of pruritus on quality of life and how it is managed in a real-world cohort. METHODS: TARGET-PBC is a longitudinal observational cohort ... Full text Link to item Cite

Health Care Transition for Adolescents and Young Adults With Pediatric-Onset Liver Disease and Transplantation: A Position Paper by the North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition.

Journal article J Pediatr Gastroenterol Nutr · January 1, 2023 Advances in medical therapies and liver transplantation have resulted in a greater number of pediatric patients reaching young adulthood. However, there is an increased risk for medical complications and morbidity surrounding transfer from pediatric to adu ... Full text Link to item Cite

Itching to find a diagnosis.

Journal article Clin Liver Dis (Hoboken) · September 2022 Content available: Audio Recording. ... Full text Link to item Cite

More Than Meets the Eye?

Journal article Clin Liver Dis (Hoboken) · October 2021 Content available: Author Audio Recording. ... Full text Link to item Cite

Need for Pretransplant Midodrine Does Not Negatively Impact Simultaneous Liver-kidney Transplant Outcomes.

Journal article Transplant Direct · January 2021 BACKGROUND: Midodrine is often needed pretransplant to improve hemodynamics in simultaneous liver-kidney transplant candidates. Previous research has shown that patients requiring midodrine before kidney transplant alone have increased posttransplant risk ... Full text Link to item Cite

It Ain't Over Till It's Over.

Journal article Clin Liver Dis (Hoboken) · August 2020 Full text Link to item Cite

LI-RADS Treatment Response Algorithm: Performance and Diagnostic Accuracy.

Journal article Radiology · July 2019 Background In 2017, the Liver Imaging Reporting and Data System (LI-RADS) included an algorithm for the assessment of hepatocellular carcinoma (HCC) treated with local-regional therapy. The aim of the algorithm was to enable standardized evaluation of trea ... Full text Link to item Cite

Abstract 5256: A prospective study of inflammatory diet potential and risk of hepatocellular carcinoma (HCC)

Conference Cancer Research · July 1, 2018 AbstractWorldwide, hepatocellular carcinoma (HCC) is the fifth most common cancer and the second-leading cause of cancer-related death worldwide. In the U.S., the incidence rate of HCC has tripled since 1975 ... Full text Cite

Diabetes, metabolic comorbidities, and risk of hepatocellular carcinoma: Results from two prospective cohort studies.

Journal article Hepatology · May 2018 UNLABELLED: Type 2 diabetes (T2D) is a risk factor for hepatocellular carcinoma (HCC). However, it is unknown whether T2D duration or additional metabolic comorbidities further contribute to HCC risk. From the Nurses' Health Study (NHS), 120,826 women were ... Full text Link to item Cite

Differences in Phenotypes and Liver Transplantation Outcomes by Age Group in Patients with Primary Sclerosing Cholangitis.

Journal article Dig Dis Sci · November 2017 BACKGROUND: There is increasing evidence for a heterogeneity of phenotypes in primary sclerosing cholangitis (PSC), but differences across the age spectrum in adults with PSC have not been well characterized. AIMS: To characterize phenotypic variations and ... Full text Link to item Cite

Outcomes of liver retransplantation in patients with primary sclerosing cholangitis.

Journal article Liver Transpl · June 2017 Liver retransplantation in patients with primary sclerosing cholangitis (PSC) has not been well studied. The aims of this study were to characterize patients with PSC listed for and undergoing retransplantation and to describe the outcomes in these patient ... Full text Link to item Cite

Cost-Effectiveness of Risk Score–Stratified Hepatocellular Carcinoma Screening in Patients with Cirrhosis

Journal article Clinical and Translational Gastroenterology · March 1, 2017 OBJECTIVES: Hepatocellular carcinoma (HCC) surveillance with biannual ultrasound is currently recommended for all patients with cirrhosis. However, clinical implementation of this “one-size-fits-all” approach is challenging as evidenced by its low applicat ... Full text Cite

Diagnostic and Therapeutic Yield of Endoscopy in Patients with Elevated INR and Gastrointestinal Bleeding.

Journal article Am J Med · June 2016 BACKGROUND: Gastrointestinal bleeding is a well-known risk of systemic anticoagulation. However, bleeding in the setting of supratherapeutic anticoagulation may have a milder natural history than unprovoked bleeding. It is a common clinical gestalt that en ... Full text Link to item Cite

Impact of EGF, IL28B, and PNPLA3 polymorphisms on the outcome of allograft hepatitis C: a multicenter study.

Journal article Clin Transplant · April 2016 Hepatitis C virus (HCV) infection is accelerated following liver transplantation (LT). Single nucleotide polymorphisms (SNPs) near the epidermal growth factor (EGF) (rs4444903), IL28B (rs12979860), and PNPLA3 (rs738409) loci are associated with treatment r ... Full text Link to item Cite

NSAID Use and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma: The Liver Cancer Pooling Project.

Journal article Cancer Prev Res (Phila) · December 2015 Chronic inflammation plays a pivotal role in the pathogenesis of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC), the two most common types of liver cancer. A number of prior experimental studies have suggested that nonsteroidal an ... Full text Link to item Cite

Circulating soluble CD163 is associated with steatohepatitis and advanced fibrosis in nonalcoholic fatty liver disease

Journal article Clinical and Translational Gastroenterology · October 8, 2015 OBJECTIVES: Soluble CD163 (sCD163), a marker of Kupffer cell activation detectable in serum, correlates with inflammation and fibrosis in chronic viral hepatitis, but its role in nonalcoholic fatty liver disease is unknown. We hypothesized that sCD163 woul ... Full text Cite

Coffee Consumption and Risk of Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma by Sex: The Liver Cancer Pooling Project.

Journal article Cancer Epidemiol Biomarkers Prev · September 2015 BACKGROUND: Coffee consumption has been reported to be inversely associated with hepatocellular carcinoma (HCC), the most common type of liver cancer. Caffeine has chemopreventive properties, but whether caffeine is responsible for the coffee-HCC associati ... Full text Link to item Cite

A genomic and clinical prognostic index for hepatitis C-related early-stage cirrhosis that predicts clinical deterioration.

Journal article Gut · August 2015 OBJECTIVE: The number of patients with HCV-related cirrhosis is increasing, leading to a rising risk of complications and death. Prognostic stratification in patients with early-stage cirrhosis is still challenging. We aimed to develop and validate a clini ... Full text Link to item Cite

Obstructive Sleep Apnea Is Associated with Nonalcoholic Steatohepatitis and Advanced Liver Histology.

Journal article Dig Dis Sci · August 2015 BACKGROUND AND AIMS: Nonalcoholic fatty liver disease (NAFLD) and obstructive sleep apnea (OSA) are growing in prevalence in the USA. Existing data on the relationship between OSA and NAFLD are conflicting and limited by the use of various histologic defin ... Full text Link to item Cite

Reduced Albumin Dosing During Large-Volume Paracentesis Is Not Associated with Adverse Clinical Outcomes.

Journal article Dig Dis Sci · July 2015 BACKGROUND: LVP is used to manage diuretic-resistant ascites in cirrhotic patients. Albumin administration prevents complications including acute kidney injury and paracentesis-induced circulatory dysfunction, but the optimal dose is unclear. AIM: We sough ... Full text Link to item Cite

Reproductive factors, exogenous hormone use and risk of hepatocellular carcinoma among US women: results from the Liver Cancer Pooling Project.

Journal article Br J Cancer · March 31, 2015 BACKGROUND: Hepatocellular carcinoma (HCC) occurs less commonly among women than men in almost all regions of the world. The disparity in risk is particularly notable prior to menopause suggesting that hormonal exposures during reproductive life may be pro ... Full text Link to item Cite

Gaps in recognition and evaluation of incidentally identified hepatic steatosis.

Journal article Dig Dis Sci · February 2015 BACKGROUND: Nonalcoholic fatty liver disease (NAFLD), the most common cause of liver disease, is frequently diagnosed incidentally on imaging. The goal of the present study was to characterize rates of documentation and evaluation of incidentally identifie ... Full text Link to item Cite

Statin use is associated with a reduced risk of fibrosis progression in chronic hepatitis C.

Journal article J Hepatol · January 2015 BACKGROUND & AIMS: Therapies that slow fibrosis progression in chronic liver disease are needed. Animal models have demonstrated that statins prevent the progression of hepatic fibrosis, but human data is lacking so far. We evaluated the association betwee ... Full text Link to item Cite

Hepatitis C virus-associated cancer.

Journal article Annu Rev Pathol · 2015 Hepatitis C virus (HCV) is one of the major etiologic agents of liver cancer. HCV is an RNA virus that, unlike hepatitis B virus, is unable to integrate into the host genome. Through complex interactions between viral and host proteins that induce host res ... Full text Link to item Cite

Host genetics predict clinical deterioration in HCV-related cirrhosis.

Journal article PLoS One · 2014 Single nucleotide polymorphisms (SNPs) in the epidermal growth factor (EGF, rs4444903), patatin-like phospholipase domain-containing protein 3 (PNPLA3, rs738409) genes, and near the interleukin-28B (IL28B, rs12979860) gene are linked to treatment response, ... Full text Link to item Cite

Advanced disease, diuretic use, and marital status predict hospital admissions in an ambulatory cirrhosis cohort

Journal article Digestive Diseases and Sciences · January 1, 2014 Background and Aims: Hospital admissions in cirrhotic patients are a source of significant health care expenditure. Most studies to date have focused on readmissions in patients with decompensated cirrhosis. We sought to describe predictors of hospital adm ... Full text Cite

Reply: To PMID 22885329.

Journal article Gastroenterology · January 2013 Full text Link to item Cite

Development of an accurate index for predicting outcomes of patients with acute liver failure.

Journal article Gastroenterology · November 2012 BACKGROUND & AIMS: Patients with acute liver failure (ALF) have high mortality and frequently require liver transplantation (LT); few reliable prognostic markers are available. Levels of M30, a cleavage product of cytokeratin-18 caspase, are significantly ... Full text Link to item Cite

When treating cancer, please don't forget hepatitis B.

Journal article Oncologist · 2010 Four cases highlighting the reactivation of hepatitis B virus during chemotherapy are presented and the current data and guidelines for pre-emptive management are reviewed. ... Full text Link to item Cite