Lindsay A. Riley

Journal article Biomaterials · June 2026 Fibrotic responses at biomaterial-tissue interfaces limit implant integration and regenerative healing, yet how the interaction between biomaterials and the extracellular matrix (ECM) regulates fibroblast activation remains poorly understood. Granular hydr ... Full text Cite

Metrics for Studying the Porous Void Space of Packed Particles

Journal article Particle and Particle Systems Characterization · February 1, 2026 Characterizing porosity in packed particle assemblies is a complex task that requires advanced analytical tools. We present a visually rich and extensive library of global, pore-based, and other metrics for analyzing features of porosity in such assemblies ... Full text Cite

Metrics for studying the porous void space of packed particles.

Journal article bioRxiv · July 28, 2025 Characterizing porosity in packed particle assemblies is a complex task that requires advanced analytical tools. We present a visually rich and extensive library of global, pore-based, and other metrics for analyzing features of porosity in such assemblies ... Full text Link to item Cite

Delivery of Angiogenic Therapy from Flowable Hyaluronic Acid Porous Scaffolds Results in Functional Improvement without Anti-Inflammatory Agents.

Journal article Advanced functional materials · July 2025 Ischemic stroke, a blockage in the vasculature of the brain that results in insufficient blood flow, is one of the world's leading causes of disability. The cascade of inflammation and cell death that occurs immediately following stroke drives vascular and ... Full text Cite

Clustered VEGF Nanoparticles in Microporous Annealed Particle (MAP) Hydrogel Accelerates Functional Recovery and Brain Tissue Repair after Stroke.

Journal article bioRxiv · February 5, 2025 Ischemic stroke, a blockage in the vasculature of the brain that results in insufficient blood flow, is one of the world's leading causes of disability. The cascade of inflammation and cell death that occurs immediately following stroke drives vascular and ... Full text Link to item Cite

Engineering the microstructure and spatial bioactivity of MAP scaffolds instructs vasculogenesis in vitro and modifies vessel formation in vivo.

Journal article Advanced functional materials · January 2025 In tissues where the vasculature is either lacking or abnormal, biomaterials can be designed to promote vessel formation and enhance tissue repair. In this work, we independently tune the microstructure and bioactivity of microporous annealed particle (MAP ... Full text Open Access Cite

Highly porous granular hydrogels reinforced by electrospun hydrogel fibers for long-term stability

Preprint · 2024 Granular hydrogels (GHs) formed from hydrogel microparticles (HMPs) possess inherent, microscale porosity. In GHs including microporous annealed particle (MAP) hydrogels as well as unannealed GHs, increases in pore size and total porosity correlate with en ... Full text Cite

Exploring the Role of Spatial Confinement in Immune Cell Recruitment and Regeneration of Skin Wounds.

Journal article Advanced materials (Deerfield Beach, Fla.) · December 2023 Microporous annealed particle (MAP) scaffolds are injectable granular materials comprised of micron sized hydrogel particles (microgels). The diameter of these microgels directly determines the size of the interconnected void space between particles where ... Full text Cite

Identification and analysis of 3D pores in packed particulate materials

Journal article Nature Computational Science · November 21, 2023 We took the classic ‘guess the number of beans in a jar game’ and amplified the research question. Rather than estimate the quantity of particles in the jar, we sought to characterize the spaces between them. Here we present an approach for delineating the ... Full text Cite

Spatial Confinement Modulates Macrophage Response in Microporous Annealed Particle (MAP) Scaffolds.

Journal article Advanced healthcare materials · October 2023 Macrophages are essential in the initiation, maintenance, and transition of inflammatory processes such as foreign body response and wound healing. Mounting evidence suggests that physical factors also modulate macrophage activation. 2D in vitro systems de ... Full text Cite

Void Volume Fraction of Granular Scaffolds.

Journal article Small (Weinheim an der Bergstrasse, Germany) · October 2023 Void volume fraction (VVF) is a global measurement frequently used to characterize the void space of granular scaffolds, yet there is no gold standard by which to measure VVF in practice. To study the relationship between VVF and particles of varying size ... Full text Cite

Engineering the microstructure and spatial bioactivity of MAP scaffolds in vitro instructs neovascularization in vivo

Preprint · 2023 In tissues where the vasculature is either lacking or abnormal, biomaterials can be designed to promote vessel formation and enhance tissue repair. In this work, we independently tune the microstructure and bioactivity of microporous annealed particle (MAP ... Full text Cite

Hydrogel microparticles for biomedical applications.

Journal article Nature reviews. Materials · January 2020 Hydrogel microparticles (HMPs) are promising for biomedical applications, ranging from the therapeutic delivery of cells and drugs to the production of scaffolds for tissue repair and bioinks for 3D printing. Biologics (cells and drugs) can be encapsulated ... Full text Cite

Granular hydrogels: emergent properties of jammed hydrogel microparticles and their applications in tissue repair and regeneration.

Journal article Current opinion in biotechnology · December 2019 Granular hydrogels are emerging as a versatile and effective platform for tissue engineered constructs in regenerative medicine. The hydrogel microparticles (HMPs) that compose these materials exhibit particle jamming above a minimum packing fraction, whic ... Full text Cite

Determining duration of HER2-targeted therapy using stem cell extinction models.

Journal article PloS one · January 2012 IntroductionTrastuzumab dramatically improves survival in breast cancer patients whose tumor overexpresses HER2. A subpopulation of cells in human breast tumors has been identified with characteristics of cancer stem cells. These breast cancer ste ... Full text Cite

Predicted structures of agonist and antagonist bound complexes of adenosine A3 receptor.

Journal article Proteins · June 2011 We used the GEnSeMBLE Monte Carlo method to predict ensemble of the 20 best packings (helix rotations and tilts) based on the neutral total energy (E) from a vast number (10 trillion) of potential packings for each of the four subtypes of the adenosine G p ... Full text Cite