Current Appointments & Affiliations
Assistant Professor of Pathology
·
2023 - Present
Pathology,
Clinical Science Departments
Member of the Duke Cancer Institute
·
2023 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
The sotos syndrome gene Nsd1 safeguards developmental gene enhancers poised for transcription by maintaining the precise deposition of histone methylation.
Journal Article J Biol Chem · March 19, 2025 Germline haploinsufficiency of NSD1 is implicated as the etiology of Sotos syndrome; however, the underlying mechanism remains far from being clear. Here, we use mouse embryonic stem cell (mESC) differentiation as a model system to address this question. W ... Full text Link to item CiteThe phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators.
Journal Article Mol Cell · February 20, 2025 Recurrent cancer-causing fusions of NUP98 produce higher-order assemblies known as condensates. How NUP98 oncofusion-driven condensates activate oncogenes remains poorly understood. Here, we investigate NUP98-PHF23, a leukemogenic chimera of the disordered ... Full text Link to item CiteEZH2 PROTACs target EZH2- and FOXM1-associated oncogenic nodes, suppressing breast cancer cell growth.
Journal Article Oncogene · August 2024 Breast cancer (BC) remains the second leading cause of cancer-related mortalities in women. Resistance to hormone therapies such as tamoxifen, an estrogen receptor (ER) inhibitor, is a major hurdle in the treatment of BC. Enhancer of zeste homolog 2 (EZH2) ... Full text Link to item CiteRecent Grants
The Role of YY1 in Castration-Resistant Prostate Cancer
ResearchPrincipal Investigator · Awarded by National Cancer Institute · 2023 - 2026View All Grants
Education, Training & Certifications
University of California, San Diego ·
2008
Ph.D.