Scholars@Duke
Lisa Deneen Hobson-Webb

Lisa Deneen Hobson-Webb

Professor of Neurology
Neurology, Neuromuscular Disease
lisa.hobsonwebb@duke.edu
Duke Box 3403, Durham, NC 27710
Dept of Medicine, Division of Neurology, Durham, NC 27710

Scholarly Works - Conferences

The Duke MG Patient Registry III. Comparative Effectiveness of Azathioprine and Mycophenolate Mofetil in Generalized Myasthenia Gravis, a Retrospective Single Center Review.

Conference Muscle Nerve · May 2026 INTRODUCTION/AIMS: Azathioprine (AZA) and mycophenolate mofetil (MMF) are the most commonly used non-steroidal immunosuppressants in patients with generalized myasthenia gravis (gMG) in North America but their relative effectiveness among disease subgroups ... Full text Link to item Cite

Volumetric Mechanical Characterization of in vivo Skeletal Muscle Assessed with 3D-Rotational Shear Wave Elasticity Imaging (3D-RSWEI)

Conference IEEE International Ultrasonics Symposium Ius · January 1, 2025 We present a volumetric characterization method for 3D-RSWEI data in in vivo skeletal muscle, in which shear wave speeds (SWS) are quantified at multiple rotational angles through multiple axial depths within the depth-of-field. We have shown in the vastus ... Full text Cite

Pregnancy in MuSK-positive myasthenia gravis: A single-center case series.

Conference Muscle Nerve · July 2023 INTRODUCTION/AIMS: Myasthenia gravis (MG) with muscle-specific tyrosine kinase (MuSK) antibodies (MMG) is predominantly seen in women of childbearing age. Our objective in this study was to describe the course of MMG during pregnancy and within 6 months po ... Full text Link to item Cite

The Duke Myasthenia Gravis Clinic Registry: II. Analysis of outcomes.

Conference Muscle Nerve · April 2023 INTRODUCTION/AIMS: The Duke Myasthenia Gravis (MG) Clinic Registry contains comprehensive physician-derived data on patients with MG seen in the Duke MG Clinic since 1980. The aim of this study was to report outcomes in patients seen in the clinic and trea ... Full text Link to item Cite

Knowledge and perceptions of the COVID-19 pandemic among patients with myasthenia gravis: follow up survey

Conference RRNMF Neuromuscular Journal · February 7, 2023 Introduction  We previously conducted a survey study in April 2020 at the beginning of the SARS-CoV-2 (COVID-19) pandemic to understand how it affected patients with myasthenia gravis (MG). Since then, significant advances have occurred in th ... Full text Open Access Cite

An Open-Source Radon-Transform Shear Wave Speed Estimator with Masking Functionality to Isolate Different Shear-Wave Modes

Conference IEEE International Ultrasonics Symposium Ius · January 1, 2022 The Radon Transform (RT) approach is a common method used to estimate shear wave trajectory and speed in ultrasound shear wave elasticity imaging (SWEI). The RT calculates the sum of 2D spatiotemporal data amplitude under each potential linear trajectory t ... Full text Cite

Group Shear Wave Speed Viscoelastic Analysis using 3D Rotational Volumetric Shear Wave Imaging in Relaxed and Contracted in vivo Muscle

Conference IEEE International Ultrasonics Symposium Ius · January 1, 2021 To characterize muscle tissue as a viscoelastic transversely isotropic material, we use rotational volumetric shear wave elasticity imaging (SWEI) and group speed viscoelastic analysis. We performed these measurements in vivo in the vastus lateralis of two ... Full text Cite

Quantification of Skeletal Muscle Fiber Orientation in 3D Ultrasound B-Modes

Conference IEEE International Ultrasonics Symposium Ius · January 1, 2021 Skeletal muscle exhibits transverse isotropy with a symmetry axis in the muscle fiber direction. Characterization of muscle mechanical properties with ultrasound shear wave elasticity imaging requires an accurate measurement of the 3D muscle fiber orientat ... Full text Cite

Factors Affecting in vivo SH and SV Mode Wave Propagation in vastus lateralis Muscle at Varying Knee Flexion Angles Using Ultrasonic Rotational 3D SWEI

Conference IEEE International Ultrasonics Symposium Ius · January 1, 2021 We previously have demonstrated the use of ultrasonic rotational 3D SWEI to measure all three mechanical properties necessary to fully characterize the vastus lateralis muscle in vivo as an incompressible transversely isotropic material: transverse shear m ... Full text Cite

Viscoelastic Characterization in Muscle using Group Speed Analysis and Volumetric Shear Wave Elasticity Imaging

Conference IEEE International Ultrasonics Symposium Ius · September 7, 2020 Shear wave elasticity imaging (SWEI) typically assumes a homogeneous, isotropic, elastic material to relate shear wave speed (SWS) to stiffness; however muscle is anisotropic and viscoelastic (VE). To characterize this complex tissue, we combine 3D SWEI (a ... Full text Cite

Demonstration of Complex Shear Wave Patterns in Skeletal Muscle in vivo Using 3D SWEI

Conference IEEE International Ultrasonics Symposium Ius · September 7, 2020 Shear wave elastography imaging (SWEI) of skeletal muscle has previously been used to identify speeds along and across the fibers, with limited success and low repeatability. In this work we show how a tilted configuration can be used to fully characterize ... Full text Cite

Respiratory muscle training in Pompe disease

Conference Molecular Genetics and Metabolism · February 2018 Full text Cite

Lingual pathophysiology in late-onset Pompe disease

Conference Molecular Genetics and Metabolism · February 2018 Full text Cite

Population Pharmacokinetics/Pharmacodynamics of 3,4-Diaminopyridine Free Base in Patients With Lambert-Eaton Myasthenia.

Conference CPT Pharmacometrics Syst Pharmacol · September 2017 Lambert-Eaton myasthenia (LEM) is a rare autoimmune disorder associated with debilitating muscle weakness. There are limited treatment options and 3,4-diaminopyridine (3,4-DAP) free base is an investigational orphan drug used to treat LEM-related weakness. ... Full text Link to item Cite

UTILITY OF ULTRASOUND IN MUSCLE BIOPSY

Conference MUSCLE & NERVE · September 2016 Link to item Cite

INCREASED OCCURRENCE OF LATE ONSET MYASTHENIA GRAVIS

Conference MUSCLE & NERVE · October 1, 2011 Link to item Cite