Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Princeton University 1992
• 

  Duke Appointment History

  • Assistant Professor in Radiology, Radiology, Cardiothoracic Imaging, Radiology 2006 - 2018
  • Assistant Research Professor in Radiology, Radiology, Cardiothoracic Imaging, Radiology 2005 - 2006
  • Instructor, Temporary of Radiology, Radiology, Clinical Science Departments 2004 - 2005
• Expertise
• 

  Subject Headings

  • Algorithms
  • Amino Acid Sequence
  • Antibody Specificity
  • Antigens, Neoplasm
  • B-Lymphocytes
  • Bacterial Proteins
  • Bacteriophage M13
  • Binding Sites
  • Binding, Competitive
  • Biological Markers
  • Blotting, Western
  • Catalysis
  • Cell Cycle Proteins
  • Cell Line
  • DNA, Bacterial
  • DNA, Superhelical
  • Diagnosis, Differential
  • Dose-Response Relationship, Drug
  • Drug Design
  • Escherichia coli
  • Estradiol
  • Estradiol Congeners
  • Estriol
  • Estrogen Antagonists
  • Estrogen Receptor alpha
  • Estrogen Receptor beta
  • Estrogens
  • Germinal Center
  • Histidine
  • Humans
  • Hydrolysis
  • Immunoprecipitation
  • Inhibitory Concentration 50
  • Kinetics
  • Lung Diseases
  • Lung Neoplasms
  • Models, Chemical
  • Molecular Sequence Data
  • Mutagenesis, Site-Directed
  • Neoplasm Staging
  • Pancreatic Neoplasms
  • Peptide Fragments
  • Peptides
  • Phospholipase D
  • Phylogeny
  • Prognosis
  • Protein Biosynthesis
  • Protein Conformation
  • Receptors, Estrogen
  • Recombinant Proteins
  • Reverse Transcriptase Polymerase Chain Reaction
  • Solitary Pulmonary Nodule
  • Substrate Specificity
  • Surface Plasmon Resonance
  • Tamoxifen
  • Thermodynamics
  • Transcription, Genetic
  • Tumor Markers, Biological
• Research
• 

  Selected Grants

  • Development of a Prognostic Marker for Lung Cancer Using Analysis of Tumor Evolution awarded by Department of Defense 2015 - 2019
• 

  External Relationships

  • Grid Therapeutics, LLC (formerly Cue Biologics, LLC)
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Ashton, Jeffrey R., Elizabeth B. Gottlin, Edward F. Patz, Jennifer L. West, and Cristian T. Badea. “A comparative analysis of EGFR-targeting antibodies for gold nanoparticle CT imaging of lung cancer.” Plos One 13, no. 11 (2018): e0206950. https://doi.org/10.1371/journal.pone.0206950.
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    • Campa, Michael J., Elizabeth B. Gottlin, James E. Herndon, and Edward F. Patz. “Rethinking Autoantibody Signature Panels for Cancer Diagnosis.” J Thorac Oncol 12, no. 6 (June 2017): 1011–14. https://doi.org/10.1016/j.jtho.2017.01.017.
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    • Winkler, Mark T., Ryan T. Bushey, Elizabeth B. Gottlin, Michael J. Campa, Eross S. Guadalupe, Alicia D. Volkheimer, J Brice Weinberg, and Edward F. Patz. “Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody.” Plos One 12, no. 6 (2017): e0179841. https://doi.org/10.1371/journal.pone.0179841.
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    • Bushey, Ryan T., M Anthony Moody, Nathan L. Nicely, Barton F. Haynes, S Munir Alam, Stephen T. Keir, Rex C. Bentley, et al. “A Therapeutic Antibody for Cancer, Derived from Single Human B Cells.” Cell Rep 15, no. 7 (May 17, 2016): 1505–13. https://doi.org/10.1016/j.celrep.2016.04.038.
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    • Campa, Michael J., M Anthony Moody, Ruijun Zhang, Hua-Xin Liao, Elizabeth B. Gottlin, and Edward F. Patz. “Interrogation of individual intratumoral B lymphocytes from lung cancer patients for molecular target discovery.” Cancer Immunol Immunother 65, no. 2 (February 2016): 171–80. https://doi.org/10.1007/s00262-015-1787-0.
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    • Campa, Michael J., Elizabeth B. Gottlin, Ryan T. Bushey, and Edward F. Patz. “Complement Factor H Antibodies from Lung Cancer Patients Induce Complement-Dependent Lysis of Tumor Cells, Suggesting a Novel Immunotherapeutic Strategy.” Cancer Immunol Res 3, no. 12 (December 2015): 1325–32. https://doi.org/10.1158/2326-6066.CIR-15-0122.
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    • Patz, Edward F., Michael J. Campa, Elizabeth B. Gottlin, Priscilla R. Trotter, James E. Herndon, Don Kafader, Russell P. Grant, and Marcia Eisenberg. “Biomarkers to help guide management of patients with pulmonary nodules.” Am J Respir Crit Care Med 188, no. 4 (August 15, 2013): 461–65. https://doi.org/10.1164/rccm.201210-1760OC.
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    • Roberts, Andrew S., Michael J. Campa, Elizabeth B. Gottlin, Chen Jiang, Kouros Owzar, Hedy L. Kindler, Alan P. Venook, Richard M. Goldberg, Eileen M. O’Reilly, and Edward F. Patz. “Identification of potential prognostic biomarkers in patients with untreated, advanced pancreatic cancer from a phase 3 trial (Cancer and Leukemia Group B 80303).” Cancer 118, no. 2 (January 15, 2012): 571–78. https://doi.org/10.1002/cncr.26270.
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    • Gottlin, Elizabeth B., Rex C. Bentley, Michael J. Campa, David S. Pisetsky, James E. Herndon, and Edward F. Patz. “The Association of Intratumoral Germinal Centers with early-stage non-small cell lung cancer.” J Thorac Oncol 6, no. 10 (October 2011): 1687–90. https://doi.org/10.1097/JTO.0b013e3182217bec.
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    • Auffermann, W. F., L. Washington, E. B. Gottlin, and E. F. Patz. “The role of biomarkers in thoracic imaging.” Imaging in Medicine 2, no. 5 (October 1, 2010): 575–81. https://doi.org/10.2217/iim.10.47.
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    • Amornsiripanitch, Nita, Shaolin Hong, Michael J. Campa, Michael M. Frank, Elizabeth B. Gottlin, and Edward F. Patz. “Complement factor H autoantibodies are associated with early stage NSCLC.” Clin Cancer Res 16, no. 12 (June 15, 2010): 3226–31. https://doi.org/10.1158/1078-0432.CCR-10-0321.
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    • Gottlin, Elizabeth B., Elizabeth B. Xiangrong Guan, Charles Pegram, Allen Cannedy, Michael J. Campa, and Edward F. Patz. “Isolation of novel EGFR-specific VHH domains.” J Biomol Screen 14, no. 1 (January 2009): 77–85. https://doi.org/10.1177/1087057108327064.
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    • Patz, Edward F., Michael J. Campa, Elizabeth B. Gottlin, Irina Kusmartseva, Xiang Rong Guan, and James E. Herndon. “Panel of serum biomarkers for the diagnosis of lung cancer.” J Clin Oncol 25, no. 35 (December 10, 2007): 5578–83. https://doi.org/10.1200/JCO.2007.13.5392.
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    • Hoagland, Luke F. M., Michael J. Campa, Elizabeth B. Gottlin, James E. Herndon, and Edward F. Patz. “Haptoglobin and posttranslational glycan-modified derivatives as serum biomarkers for the diagnosis of nonsmall cell lung cancer.” Cancer 110, no. 10 (November 15, 2007): 2260–68. https://doi.org/10.1002/cncr.23049.
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    • Benson, R Edward, Elizabeth B. Gottlin, Dale J. Christensen, and Paul T. Hamilton. “Intracellular expression of Peptide fusions for demonstration of protein essentiality in bacteria.” Antimicrob Agents Chemother 47, no. 9 (September 2003): 2875–81. https://doi.org/10.1128/aac.47.9.2875-2881.2003.
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    • Gottlin, Elizabeth B., R Edward Benson, Scott Conary, Brett Antonio, Kellie Duke, E Sturgis Payne, S Salman Ashraf, and Dale J. Christensen. “High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition.” J Biomol Screen 8, no. 3 (June 2003): 332–39. https://doi.org/10.1177/1087057103008003011.
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    • Christensen, D. J., E. B. Gottlin, R. E. Benson, and P. T. Hamilton. “Phage display for target-based antibacterial drug discovery.” Drug Discov Today 6, no. 14 (July 1, 2001): 721–27. https://doi.org/10.1016/s1359-6446(01)01853-0.
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    • Paige, L. A., D. J. Christensen, H. Grøn, J. D. Norris, E. B. Gottlin, K. M. Padilla, C. Y. Chang, et al. “Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta.” Proc Natl Acad Sci U S A 96, no. 7 (March 30, 1999): 3999–4004. https://doi.org/10.1073/pnas.96.7.3999.
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    • Gottlin, E. B., A. E. Rudolph, Y. Zhao, H. R. Matthews, and J. E. Dixon. “Catalytic mechanism of the phospholipase D superfamily proceeds via a covalent phosphohistidine intermediate.” Proc Natl Acad Sci U S A 95, no. 16 (August 4, 1998): 9202–7. https://doi.org/10.1073/pnas.95.16.9202.
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    • Gottlin, E. B., X. Xu, D. M. Epstein, S. P. Burke, J. W. Eckstein, D. P. Ballou, and J. E. Dixon. “Kinetic analysis of the catalytic domain of human cdc25B.” J Biol Chem 271, no. 44 (November 1, 1996): 27445–49. https://doi.org/10.1074/jbc.271.44.27445.
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    • Surette, M. G., M. Levit, Y. Liu, G. Lukat, E. G. Ninfa, A. Ninfa, and J. B. Stock. “Dimerization is required for the activity of the protein histidine kinase CheA that mediates signal transduction in bacterial chemotaxis.” J Biol Chem 271, no. 2 (January 12, 1996): 939–45. https://doi.org/10.1074/jbc.271.2.939.
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    • Ninfa, E. G., and J. E. Dixon. “Protein tyrosine phosphatases in disease processes.” Trends in Cell Biology 4, no. 12 (January 1, 1994): 427–30. https://doi.org/10.1016/0962-8924(94)90103-1.
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    • Ninfa, E. G., M. R. Atkinson, E. S. Kamberov, and A. J. Ninfa. “Mechanism of autophosphorylation of Escherichia coli nitrogen regulator II (NRII or NtrB): trans-phosphorylation between subunits.” J Bacteriol 175, no. 21 (November 1993): 7024–32. https://doi.org/10.1128/jb.175.21.7024-7032.1993.
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    • Ohta, N., T. Lane, E. G. Ninfa, J. M. Sommer, and A. Newton. “A histidine protein kinase homologue required for regulation of bacterial cell division and differentiation.” Proc Natl Acad Sci U S A 89, no. 21 (November 1, 1992): 10297–301. https://doi.org/10.1073/pnas.89.21.10297.
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    • Ninfa, E. G., A. Stock, S. Mowbray, and J. Stock. “Reconstitution of the bacterial chemotaxis signal transduction system from purified components.” J Biol Chem 266, no. 15 (May 25, 1991): 9764–70.
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    • Olmedo, G., E. G. Ninfa, J. Stock, and P. Youngman. “Novel mutations that alter the regulation of sporulation in Bacillus subtilis. Evidence that phosphorylation of regulatory protein SpoOA controls the initiation of sporulation.” J Mol Biol 215, no. 3 (October 5, 1990): 359–72. https://doi.org/10.1016/s0022-2836(05)80357-2.
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    • Ninfa, A. J., E. G. Ninfa, A. N. Lupas, A. Stock, B. Magasanik, and J. Stock. “Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism.” Proc Natl Acad Sci U S A 85, no. 15 (August 1988): 5492–96. https://doi.org/10.1073/pnas.85.15.5492.
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    • Stock, A. M., D. C. Wylie, J. M. Mottonen, A. N. Lupas, E. G. Ninfa, A. J. Ninfa, C. E. Schutt, and J. B. Stock. “Phosphoproteins involved in bacterial signal transduction.” Cold Spring Harbor Symposia on Quantitative Biology 53, no. 1 (1988): 49–57.
    • Donahoe, P. K., R. L. Cate, D. T. MacLaughlin, J. Epstein, A. F. Fuller, M. Takahashi, J. P. Coughlin, E. G. Ninfa, and L. A. Taylor. “Müllerian inhibiting substance: gene structure and mechanism of action of a fetal regressor.” Recent Prog Horm Res 43 (1987): 431–67. https://doi.org/10.1016/b978-0-12-571143-2.50017-4.
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    • Cate, R. L., R. J. Mattaliano, C. Hession, R. Tizard, N. M. Farber, A. Cheung, E. G. Ninfa, A. Z. Frey, D. J. Gash, and E. P. Chow. “Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells.” Cell 45, no. 5 (June 1986): 685–98. https://doi.org/10.1016/0092-8674(86)90783-x.
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    • Gottlin-Ninfa, E., and D. B. Kaback. “Isolation and functional analysis of sporulation-induced transcribed sequences from Saccharomyces cerevisiae.” Mol Cell Biol 6, no. 6 (June 1986): 2185–97. https://doi.org/10.1128/mcb.6.6.2185.
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    • Cate, R. L., E. G. Ninfa, D. J. Pratt, D. T. MacLaughlin, and P. K. Donahoe. “Development of mullerian inhibiting substance as an anti-cancer drug.” Cold Spring Harb Symp Quant Biol 51 Pt 1 (1986): 641–47. https://doi.org/10.1101/sqb.1986.051.01.076.
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    • Cate, R. L., E. G. Ninfa, D. J. Pratt, D. T. MacLaughlin, and P. K. Donahoe. “Development of Mullerian inhibiting substance as an anti-cancer drug.” Cold Spring Harbor Symposia on Quantitative Biology 51, no. 1 (1986): 641–47.

  • Conference Papers

    • Stock, A. M., D. C. Wylie, J. M. Mottonen, A. N. Lupas, E. G. Ninfa, A. J. Ninfa, C. E. Schutt, and J. B. Stock. “Phosphoproteins involved in bacterial signal transduction.” In Cold Spring Harb Symp Quant Biol, 53 Pt 1:49–57, 1988. https://doi.org/10.1101/sqb.1988.053.01.009.
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