Elizabeth B. Gottlin | Scholars@Duke

Elizabeth B. Gottlin
Assistant Professor in Radiology

Current Appointments & Affiliations

Assistant Professor in Radiology, Radiology, Cardiothoracic Imaging, Radiology 2006

Contact Information

Box 2610 Med Ctr, MSRB - Research Drive, Durham, NC 27710
Radiology, Room 118 - MSRB, Durham, NC 27710
liz.gottlin@duke.edu (919) 681-3092

Background
Education, Training, & Certifications
- Ph.D., Princeton University 1992
Duke Appointment History
- Assistant Research Professor in Radiology, Radiology, Cardiothoracic Imaging, Radiology 2005 - 2006
- Instructor, Temporary of Radiology, Radiology, Clinical Science Departments 2004 - 2005
Expertise
Subject Headings
Research
Selected Grants
- Development of a Prognostic Marker for Lung Cancer Using Analysis of Tumor Evolution awarded by Department of Defense 2015 - 2018
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Stock, AM, Wylie, DC, Mottonen, JM, Lupas, AN, Ninfa, EG, Ninfa, AJ, Schutt, CE, and Stock, JB. "Phosphoproteins involved in bacterial signal transduction." January 1988. Full Text
- Journal Articles
  - Campa, MJ, Gottlin, EB, Herndon, JE, and Patz, EF. "Rethinking Autoantibody Signature Panels for Cancer Diagnosis." Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 12, no. 6 (June 2017): 1011-1014. Full Text
  - Winkler, MT, Bushey, RT, Gottlin, EB, Campa, MJ, Guadalupe, ES, Volkheimer, AD, Weinberg, JB, and Patz, EF. "Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody." PloS one 12, no. 6 (January 2017): e0179841-. Full Text
  - Bushey, RT, Moody, MA, Nicely, NL, Haynes, BF, Alam, SM, Keir, ST, Bentley, RC, Roy Choudhury, K, Gottlin, EB, Campa, MJ, Liao, H-X, and Patz, EF. "A Therapeutic Antibody for Cancer, Derived from Single Human B Cells." Cell reports 15, no. 7 (May 4, 2016): 1505-1513. Full Text Open Access Copy
  - Campa, MJ, Moody, MA, Zhang, R, Liao, H-X, Gottlin, EB, and Patz, EF. "Interrogation of individual intratumoral B lymphocytes from lung cancer patients for molecular target discovery." Cancer immunology, immunotherapy : CII 65, no. 2 (February 2016): 171-180. Full Text Open Access Copy
  - Campa, MJ, Gottlin, EB, Bushey, RT, and Patz, EF. "Complement Factor H Antibodies from Lung Cancer Patients Induce Complement-Dependent Lysis of Tumor Cells, Suggesting a Novel Immunotherapeutic Strategy." Cancer immunology research 3, no. 12 (December 2015): 1325-1332. Full Text
  - Patz, EF, Campa, MJ, Gottlin, EB, Trotter, PR, Herndon, JE, Kafader, D, Grant, RP, and Eisenberg, M. "Biomarkers to help guide management of patients with pulmonary nodules." Am J Respir Crit Care Med 188, no. 4 (August 15, 2013): 461-465. Full Text Open Access Copy Link to Item
  - Roberts, AS, Campa, MJ, Gottlin, EB, Jiang, C, Owzar, K, Kindler, HL, Venook, AP, Goldberg, RM, O'Reilly, EM, and Patz, EF. "Identification of potential prognostic biomarkers in patients with untreated, advanced pancreatic cancer from a phase 3 trial (Cancer and Leukemia Group B 80303)." Cancer 118, no. 2 (January 15, 2012): 571-578. Full Text Link to Item
  - Gottlin, EB, Bentley, RC, Campa, MJ, Pisetsky, DS, Herndon, JE, and Patz, EF. "The Association of Intratumoral Germinal Centers with early-stage non-small cell lung cancer." J Thorac Oncol 6, no. 10 (October 2011): 1687-1690. Full Text Link to Item
  - Amornsiripanitch, N, Hong, S, Campa, MJ, Frank, MM, Gottlin, EB, and Patz, EF. "Complement factor H autoantibodies are associated with early stage NSCLC." Clin Cancer Res 16, no. 12 (June 15, 2010): 3226-3231. Full Text Link to Item
  - Auffermann, WF, Washington, L, Gottlin, EB, and Jr, EFP. "The role of biomarkers in thoracic imaging." Imaging in Medicine 2, no. 5 (2010): 575-581. Full Text
  - Gottlin, EB, Xiangrong Guan, , Pegram, C, Cannedy, A, Campa, MJ, and Patz, EF. "Isolation of novel EGFR-specific VHH domains." J Biomol Screen 14, no. 1 (January 2009): 77-85. Full Text Link to Item
  - Patz, EF, Campa, MJ, Gottlin, EB, Kusmartseva, I, Guan, XR, and Herndon, JE. "Panel of serum biomarkers for the diagnosis of lung cancer." J Clin Oncol 25, no. 35 (December 10, 2007): 5578-5583. Full Text Link to Item
  - Hoagland, LFM, Campa, MJ, Gottlin, EB, Herndon, JE, and Patz, EF. "Haptoglobin and posttranslational glycan-modified derivatives as serum biomarkers for the diagnosis of nonsmall cell lung cancer." Cancer 110, no. 10 (November 15, 2007): 2260-2268. Full Text Link to Item
  - Benson, RE, Gottlin, EB, Christensen, DJ, and Hamilton, PT. "Intracellular expression of Peptide fusions for demonstration of protein essentiality in bacteria." Antimicrob Agents Chemother 47, no. 9 (September 2003): 2875-2881. Link to Item
  - Gottlin, EB, Benson, RE, Conary, S, Antonio, B, Duke, K, Payne, ES, Ashraf, SS, and Christensen, DJ. "High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition." J Biomol Screen 8, no. 3 (June 2003): 332-339. Full Text Link to Item
  - Gottlin, EB, Benson, RE, Conary, S, Antonio, B, Duke, K, Payne, ES, Ashraf, SS, and Christensen, DJ. "High-throughput screen for inhibitors of 1-deoxy-D-xylulose 5-phosphate reductoisomerase by surrogate ligand competition." JOURNAL OF BIOMOLECULAR SCREENING 8, no. 3 (June 2003): 332-339. Full Text Link to Item
  - Christensen, DJ, Gottlin, EB, Benson, RE, and Hamilton, PT. "Phage display for target-based antibacterial drug discovery." Drug Discov Today 6, no. 14 (July 1, 2001): 721-727. Link to Item
  - Paige, LA, Christensen, DJ, Grøn, H, Norris, JD, Gottlin, EB, Padilla, KM, Chang, CY, Ballas, LM, Hamilton, PT, McDonnell, DP, and Fowlkes, DM. "Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta." Proc Natl Acad Sci U S A 96, no. 7 (March 30, 1999): 3999-4004. Link to Item
  - Gottlin, EB, Rudolph, AE, Zhao, Y, Matthews, HR, and Dixon, JE. "Catalytic mechanism of the phospholipase D superfamily proceeds via a covalent phosphohistidine intermediate." Proc Natl Acad Sci U S A 95, no. 16 (August 4, 1998): 9202-9207. Link to Item
  - Gottlin, EB, Xu, X, Epstein, DM, Burke, SP, Eckstein, JW, Ballou, DP, and Dixon, JE. "Kinetic analysis of the catalytic domain of human cdc25B." J Biol Chem 271, no. 44 (November 1, 1996): 27445-27449. Link to Item
  - Surette, MG, Leviti, M, Liu, Y, Lukat, G, Ninfa, EG, Ninfa, A, and Stock, JB. "Dimerization is required for the activity of the protein histidine kinase CheA that mediates signal transduction in bacterial chemotaxis." Journal of Biological Chemistry 271, no. 2 (1996): 939-945. Full Text
  - Ninfa, EG, and Dixon, JE. "Protein tyrosine phosphatases in disease processes." Trends in Cell Biology 4, no. 12 (1994): 427-430. Full Text
  - Ninfa, EG, Atkinson, MR, Kamberov, ES, and Ninfa, AJ. "Mechanism of autophosphorylation of Escherichia coli nitrogen regulator II (NR(II) or NtrB): trans-Phosphorylation between subunits." Journal of Bacteriology 175, no. 21 (1993): 7024-7032.
  - Ohta, N, Lane, T, Ninfa, EG, Sommer, JM, and Newton, A. "A histidine protein kinase homologue required for regulation of bacterial cell division and differentiation." Proceedings of the National Academy of Sciences of the United States of America 89, no. 21 (1992): 10297-10301.
  - Ninfa, EG, Stocke, A, Mowbray, S, and Stock, J. "Reconstitution of the bacterial chemotaxis signal transduction system from purified components." Journal of Biological Chemistry 266, no. 15 (1991): 9764-9770.
  - Olmedo, G, Ninfa, EG, Stock, J, and Youngman, P. "Novel mutations that alter the regulation of sporulation in Bacillus subtilis. Evidence that phosphorylation of regulatory protein SpoOA controls the initiation of sporulation." Journal of Molecular Biology 215, no. 3 (1990): 359-372.
  - Ninfa, AJ, Ninfa, EG, Lupas, AN, Stock, A, Magasanik, B, and Stock, J. "Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism." Proceedings of the National Academy of Sciences of the United States of America 85, no. 15 (1988): 5492-5496.
  - Stock, AM, Wylie, DC, Mottonen, JM, Lupas, AN, Ninfa, EG, Ninfa, AJ, Schutt, CE, and Stock, JB. "Phosphoproteins involved in bacterial signal transduction." Cold Spring Harbor Symposia on Quantitative Biology 53, no. 1 (1988): 49-57.
  - Donahoe, PK, Cate, RL, MacLaughlin, DT, Epstein, J, Fuller, AF, Takahashi, M, Coughlin, JP, Ninfa, EG, and Taylor, LA. "Müllerian inhibiting substance: gene structure and mechanism of action of a fetal regressor." Recent Progress in Hormone Research 43 (1987): 431-467.
  - Cate, RL, Mattaliano, RJ, Hession, C, Tizard, R, Farber, NM, Cheung, A, Ninfa, EG, Frey, AZ, Gash, DJ, Chow, EP, Fisher, RA, Bertonis, JM, Torres, G, Wallner, BP, Ramachandran, KL, Ragin, RC, Manganaro, TF, MacLaughlin, DT, and Donahoe, PK. "Isolation of the bovine and human genes for müllerian inhibiting substance and expression of the human gene in animal cells." Cell 45, no. 5 (1986): 685-698.
  - Cate, RL, Ninfa, EG, Pratt, DJ, MacLaughlin, DT, and Donahoe, PK. "Development of mullerian inhibiting substance as an anti-cancer drug." Cold Spring Harbor symposia on quantitative biology 51 Pt 1 (January 1986): 641-647. Full Text
  - Cate, RL, Ninfa, EG, Pratt, DJ, MacLaughlin, DT, and Donahoe, PK. "Development of Mullerian inhibiting substance as an anti-cancer drug." Cold Spring Harbor Symposia on Quantitative Biology 51, no. 1 (1986): 641-647.
  - Gottlin-Ninfa, E, and Kaback, DB. "Isolation and functional analysis of sporulation-induced transcribed sequences from Saccharomyces cerevisiae." Molecular and cellular biology 6, no. 6 (1986): 2185-2197.

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Education, Training, & Certifications

Duke Appointment History

Subject Headings

Selected Grants

Selected Publications

Conference Papers

Journal Articles