Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Princeton University 1992
• 

  Duke Appointment History

  • Assistant Professor in Radiology, Radiology, Cardiothoracic Imaging, Radiology 2006 - 2018
  • Assistant Research Professor in Radiology, Radiology, Cardiothoracic Imaging, Radiology 2005 - 2006
  • Instructor, Temporary of Radiology, Radiology, Clinical Science Departments 2004 - 2005
• Expertise
• 

  Subject Headings

  • Algorithms
  • Amino Acid Sequence
  • Antibody Specificity
  • Antigens, Neoplasm
  • B-Lymphocytes
  • Bacterial Proteins
  • Bacteriophage M13
  • Binding Sites
  • Binding, Competitive
  • Biological Markers
  • Blotting, Western
  • Catalysis
  • Cell Cycle Proteins
  • Cell Line
  • DNA, Bacterial
  • DNA, Superhelical
  • Diagnosis, Differential
  • Dose-Response Relationship, Drug
  • Drug Design
  • Escherichia coli
  • Estradiol
  • Estradiol Congeners
  • Estriol
  • Estrogen Antagonists
  • Estrogen Receptor alpha
  • Estrogen Receptor beta
  • Estrogens
  • Germinal Center
  • Histidine
  • Humans
  • Hydrolysis
  • Immunoprecipitation
  • Inhibitory Concentration 50
  • Kinetics
  • Lung Diseases
  • Lung Neoplasms
  • Models, Chemical
  • Molecular Sequence Data
  • Mutagenesis, Site-Directed
  • Neoplasm Staging
  • Pancreatic Neoplasms
  • Peptide Fragments
  • Peptides
  • Phospholipase D
  • Phylogeny
  • Prognosis
  • Protein Biosynthesis
  • Protein Conformation
  • Receptors, Estrogen
  • Recombinant Proteins
  • Reverse Transcriptase Polymerase Chain Reaction
  • Solitary Pulmonary Nodule
  • Substrate Specificity
  • Surface Plasmon Resonance
  • Tamoxifen
  • Thermodynamics
  • Transcription, Genetic
  • Tumor Markers, Biological
• Research
• 

  Selected Grants

  • Development of a Prognostic Marker for Lung Cancer Using Analysis of Tumor Evolution awarded by Department of Defense 2015 - 2019
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Ashton, JR, Gottlin, EB, Patz, EF, West, JL, and Badea, CT. "A comparative analysis of EGFR-targeting antibodies for gold nanoparticle CT imaging of lung cancer." Plos One 13, no. 11 (January 2018): e0206950-null.  Full Text  Open Access Copy
    • Campa, MJ, Gottlin, EB, Herndon, JE, and Patz, EF. "Rethinking Autoantibody Signature Panels for Cancer Diagnosis." Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer 12, no. 6 (June 2017): 1011-1014.  Full Text
    • Winkler, MT, Bushey, RT, Gottlin, EB, Campa, MJ, Guadalupe, ES, Volkheimer, AD, Weinberg, JB, and Patz, EF. "Enhanced CDC of B cell chronic lymphocytic leukemia cells mediated by rituximab combined with a novel anti-complement factor H antibody." Plos One 12, no. 6 (January 2017): e0179841-null.  Full Text
    • Bushey, RT, Moody, MA, Nicely, NL, Haynes, BF, Alam, SM, Keir, ST, Bentley, RC, Roy Choudhury, K, Gottlin, EB, Campa, MJ, Liao, H-X, and Patz, EF. "A Therapeutic Antibody for Cancer, Derived from Single Human B Cells." Cell Reports 15, no. 7 (May 5, 2016): 1505-1513.  Full Text  Open Access Copy
    • Campa, MJ, Moody, MA, Zhang, R, Liao, H-X, Gottlin, EB, and Patz, EF. "Interrogation of individual intratumoral B lymphocytes from lung cancer patients for molecular target discovery." Cancer immunology, immunotherapy : CII 65, no. 2 (February 2016): 171-180.  Full Text  Open Access Copy
    • Campa, MJ, Gottlin, EB, Bushey, RT, and Patz, EF. "Complement Factor H Antibodies from Lung Cancer Patients Induce Complement-Dependent Lysis of Tumor Cells, Suggesting a Novel Immunotherapeutic Strategy." Cancer immunology research 3, no. 12 (December 2015): 1325-1332.  Full Text
    • Patz, EF, Campa, MJ, Gottlin, EB, Trotter, PR, Herndon, JE, Kafader, D, Grant, RP, and Eisenberg, M. "Biomarkers to help guide management of patients with pulmonary nodules." Am J Respir Crit Care Med 188, no. 4 (August 15, 2013): 461-465.  Full Text  Open Access Copy  Link to Item
    • Roberts, AS, Campa, MJ, Gottlin, EB, Jiang, C, Owzar, K, Kindler, HL, Venook, AP, Goldberg, RM, O'Reilly, EM, and Patz, EF. "Identification of potential prognostic biomarkers in patients with untreated, advanced pancreatic cancer from a phase 3 trial (Cancer and Leukemia Group B 80303)." Cancer 118, no. 2 (January 15, 2012): 571-578.  Full Text  Link to Item
    • Gottlin, EB, Bentley, RC, Campa, MJ, Pisetsky, DS, Herndon, JE, and Patz, EF. "The Association of Intratumoral Germinal Centers with early-stage non-small cell lung cancer." J Thorac Oncol 6, no. 10 (October 2011): 1687-1690.  Full Text  Link to Item
    • Auffermann, WF, Washington, L, Gottlin, EB, and Patz, EF. "The role of biomarkers in thoracic imaging." Imaging in Medicine 2, no. 5 (October 1, 2010): 575-581. (Review)  Full Text
    • Amornsiripanitch, N, Hong, S, Campa, MJ, Frank, MM, Gottlin, EB, and Patz, EF. "Complement factor H autoantibodies are associated with early stage NSCLC." Clinical Cancer Research : an Official Journal of the American Association for Cancer Research 16, no. 12 (June 2010): 3226-3231.  Full Text
    • Gottlin, EB, Xiangrong Guan, , Pegram, C, Cannedy, A, Campa, MJ, and Patz, EF. "Isolation of novel EGFR-specific VHH domains." Journal of Biomolecular Screening 14, no. 1 (January 2009): 77-85.  Full Text
    • Patz, EF, Campa, MJ, Gottlin, EB, Kusmartseva, I, Guan, XR, and Herndon, JE. "Panel of serum biomarkers for the diagnosis of lung cancer." J Clin Oncol 25, no. 35 (December 10, 2007): 5578-5583.  Full Text  Link to Item
    • Hoagland, LFM, Campa, MJ, Gottlin, EB, Herndon, JE, and Patz, EF. "Haptoglobin and posttranslational glycan-modified derivatives as serum biomarkers for the diagnosis of nonsmall cell lung cancer." Cancer 110, no. 10 (November 15, 2007): 2260-2268.  Full Text  Link to Item
    • Benson, RE, Gottlin, EB, Christensen, DJ, and Hamilton, PT. "Intracellular expression of Peptide fusions for demonstration of protein essentiality in bacteria." Antimicrob Agents Chemother 47, no. 9 (September 2003): 2875-2881.  Link to Item
    • Gottlin, EB, Benson, RE, Conary, S, Antonio, B, Duke, K, Payne, ES, Ashraf, SS, and Christensen, DJ. "High-throughput screen for inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase by surrogate ligand competition." J Biomol Screen 8, no. 3 (June 2003): 332-339.  Full Text  Link to Item
    • Gottlin, EB, Benson, RE, Conary, S, Antonio, B, Duke, K, Payne, ES, Ashraf, SS, and Christensen, DJ. "High-throughput screen for inhibitors of 1-deoxy-D-xylulose 5-phosphate reductoisomerase by surrogate ligand competition." JOURNAL OF BIOMOLECULAR SCREENING 8, no. 3 (June 2003): 332-339.  Full Text  Link to Item
    • Christensen, DJ, Gottlin, EB, Benson, RE, and Hamilton, PT. "Phage display for target-based antibacterial drug discovery." Drug Discovery Today 6, no. 14 (July 2001): 721-727.  Full Text
    • Paige, LA, Christensen, DJ, Grøn, H, Norris, JD, Gottlin, EB, Padilla, KM, Chang, CY, Ballas, LM, Hamilton, PT, McDonnell, DP, and Fowlkes, DM. "Estrogen receptor (ER) modulators each induce distinct conformational changes in ER alpha and ER beta." Proceedings of the National Academy of Sciences of the United States of America 96, no. 7 (March 1999): 3999-4004.  Full Text
    • Gottlin, EB, Rudolph, AE, Zhao, Y, Matthews, HR, and Dixon, JE. "Catalytic mechanism of the phospholipase D superfamily proceeds via a covalent phosphohistidine intermediate." Proceedings of the National Academy of Sciences of the United States of America 95, no. 16 (August 1998): 9202-9207.  Full Text
    • Gottlin, EB, Xu, X, Epstein, DM, Burke, SP, Eckstein, JW, Ballou, DP, and Dixon, JE. "Kinetic analysis of the catalytic domain of human cdc25B." The Journal of Biological Chemistry 271, no. 44 (November 1996): 27445-27449.  Full Text
    • Surette, MG, Levit, M, Liu, Y, Lukat, G, Ninfa, EG, Ninfa, A, and Stock, JB. "Dimerization is required for the activity of the protein histidine kinase CheA that mediates signal transduction in bacterial chemotaxis." The Journal of Biological Chemistry 271, no. 2 (January 1996): 939-945.  Full Text
    • Ninfa, EG, and Dixon, JE. "Protein tyrosine phosphatases in disease processes." Trends in Cell Biology 4, no. 12 (January 1, 1994): 427-430.  Full Text
    • Ninfa, EG, Atkinson, MR, Kamberov, ES, and Ninfa, AJ. "Mechanism of autophosphorylation of Escherichia coli nitrogen regulator II (NR(II) or NtrB): trans-Phosphorylation between subunits." Journal of Bacteriology 175, no. 21 (1993): 7024-7032.
    • Ohta, N, Lane, T, Ninfa, EG, Sommer, JM, and Newton, A. "A histidine protein kinase homologue required for regulation of bacterial cell division and differentiation." Proceedings of the National Academy of Sciences of the United States of America 89, no. 21 (1992): 10297-10301.
    • Ninfa, EG, Stocke, A, Mowbray, S, and Stock, J. "Reconstitution of the bacterial chemotaxis signal transduction system from purified components." Journal of Biological Chemistry 266, no. 15 (1991): 9764-9770.
    • Olmedo, G, Ninfa, EG, Stock, J, and Youngman, P. "Novel mutations that alter the regulation of sporulation in Bacillus subtilis. Evidence that phosphorylation of regulatory protein SpoOA controls the initiation of sporulation." Journal of Molecular Biology 215, no. 3 (1990): 359-372.
    • Ninfa, AJ, Ninfa, EG, Lupas, AN, Stock, A, Magasanik, B, and Stock, J. "Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism." Proceedings of the National Academy of Sciences of the United States of America 85, no. 15 (1988): 5492-5496.
    • Stock, AM, Wylie, DC, Mottonen, JM, Lupas, AN, Ninfa, EG, Ninfa, AJ, Schutt, CE, and Stock, JB. "Phosphoproteins Involved in Bacterial Signal Transduction." Cold Spring Harbor Symposia on Quantitative Biology 53, no. 0 (January 1, 1988): 49-57.  Full Text
    • Donahoe, PK, Cate, RL, MacLaughlin, DT, Epstein, J, Fuller, AF, Takahashi, M, Coughlin, JP, Ninfa, EG, and Taylor, LA. "Müllerian inhibiting substance: gene structure and mechanism of action of a fetal regressor." Recent Progress in Hormone Research 43 (1987): 431-467.
    • Cate, RL, Mattaliano, RJ, Hession, C, Tizard, R, Farber, NM, Cheung, A, Ninfa, EG, Frey, AZ, Gash, DJ, and Chow, EP. "Isolation of the bovine and human genes for Müllerian inhibiting substance and expression of the human gene in animal cells." Cell 45, no. 5 (June 1986): 685-698.  Full Text
    • Gottlin-Ninfa, E, and Kaback, DB. "Isolation and functional analysis of sporulation-induced transcribed sequences from Saccharomyces cerevisiae." Molecular and Cellular Biology 6, no. 6 (June 1986): 2185-2197.  Full Text
    • Cate, RL, Ninfa, EG, Pratt, DJ, MacLaughlin, DT, and Donahoe, PK. "Development of mullerian inhibiting substance as an anti-cancer drug." Cold Spring Harbor symposia on quantitative biology 51 Pt 1 (January 1986): 641-647.  Full Text
    • Cate, RL, Ninfa, EG, Pratt, DJ, MacLaughlin, DT, and Donahoe, PK. "Development of Mullerian Inhibiting Substance as an Anti-cancer Drug." Cold Spring Harbor Symposia on Quantitative Biology 51, no. 0 (January 1, 1986): 641-647.  Full Text

  • Conference Papers

    • Stock, AM, Wylie, DC, Mottonen, JM, Lupas, AN, Ninfa, EG, Ninfa, AJ, Schutt, CE, and Stock, JB. "Phosphoproteins involved in bacterial signal transduction." January 1988.  Full Text

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