Lori Sullivan

Journal article Exp Cell Res · April 15, 2020 Centromeres are central to chromosome segregation and genome stability, and thus their molecular foundations are important for understanding their function and the ways in which they go awry. Human centromeres typically form at large megabase-sized arrays ... Full text Open Access Link to item Cite

Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C.

Journal article Dev Cell · August 7, 2017 Human centromeres are defined by alpha satellite DNA arrays that are distinct and chromosome specific. Most human chromosomes contain multiple alpha satellite arrays that are competent for centromere assembly. Here, we show that human centromeres are defin ... Full text Link to item Cite

α satellite DNA variation and function of the human centromere.

Journal article Nucleus · July 4, 2017 Genomic variation is a source of functional diversity that is typically studied in genic and non-coding regulatory regions. However, the extent of variation within noncoding portions of the human genome, particularly highly repetitive regions, and the func ... Full text Link to item Cite

Human centromere repositioning within euchromatin after partial chromosome deletion.

Journal article Chromosome Res · December 2016 Centromeres are defined by a specialized chromatin organization that includes nucleosomes that contain the centromeric histone variant centromere protein A (CENP-A) instead of canonical histone H3. Studies in various organisms have shown that centromeric c ... Full text Link to item Cite

Genomic variation within alpha satellite DNA influences centromere location on human chromosomes with metastable epialleles.

Journal article Genome Res · October 2016 Alpha satellite is a tandemly organized type of repetitive DNA that comprises 5% of the genome and is found at all human centromeres. A defined number of 171-bp monomers are organized into chromosome-specific higher-order repeats (HORs) that are reiterated ... Full text Open Access Link to item Cite

Nucleolar organization, ribosomal DNA array stability, and acrocentric chromosome integrity are linked to telomere function.

Journal article PLoS One · 2014 The short arms of the ten acrocentric human chromosomes share several repetitive DNAs, including ribosomal RNA genes (rDNA). The rDNA arrays correspond to nucleolar organizing regions that coalesce each cell cycle to form the nucleolus. Telomere disruption ... Full text Open Access Link to item Cite

Functional epialleles at an endogenous human centromere.

Journal article Proc Natl Acad Sci U S A · August 21, 2012 Human centromeres are defined by megabases of homogenous alpha-satellite DNA arrays that are packaged into specialized chromatin marked by the centromeric histone variant, centromeric protein A (CENP-A). Although most human chromosomes have a single higher ... Full text Open Access Link to item Cite

Genomic size of CENP-A domain is proportional to total alpha satellite array size at human centromeres and expands in cancer cells.

Journal article Chromosome Res · May 2011 Human centromeres contain multi-megabase-sized arrays of alpha satellite DNA, a family of satellite DNA repeats based on a tandemly arranged 171 bp monomer. The centromere-specific histone protein CENP-A is assembled on alpha satellite DNA within the prima ... Full text Open Access Link to item Cite

Histone modifications within the human X centromere region.

Journal article PLoS One · August 12, 2009 Human centromeres are multi-megabase regions of highly ordered arrays of alpha satellite DNA that are separated from chromosome arms by unordered alpha satellite monomers and other repetitive elements. Complexities in assembling such large repetitive regio ... Full text Open Access Link to item Cite