Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., Emory University 1989
• 

  Duke Appointment History

  • Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Translational Neuroscience, Psychiatry & Behavioral Sciences 2014 - 2020
  • Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Translational Neuroscience, Psychiatry & Behavioral Sciences 2013 - 2014
  • Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 2007 - 2013
  • Assistant Clinical Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 2006 - 2007
  • Assistant Research Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 1997 - 2006
  • Clinical Associate in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 1994 - 1997
• Research
• 

  Selected Grants

  • Evaluating Effects in the Relationship between Traumatic Brain Injury and Alzheimer's Disease: Epidemiological Determinants, Their Health-Related Causes and the Resulting Disparities awarded by United States Army Medical Research Acquisition Activity 2020 - 2023
  • IPA Larry Alan Tupler (MarxMerit) awarded by Durham Veterans Affairs Medical Center 2020 - 2022
  • IPA - Larry Allen Tupler (MIRECC) awarded by Durham Veterans Affairs Medical Center 2020 - 2022
  • IPA - Larry Allen Tupler awarded by Durham Veterans Affairs Medical Center 2018 - 2020
  • FMRI Assessment of Attention and Memory in PTSD awarded by National Institutes of Health 2006 - 2012
  • Neuroimaging of Trauma Memory and Cognitive Reappraisal in Posttraumatic Stress Disorder awarded by National Institutes of Health 2009
  • IPA-Larry Tupler awarded by Veterans Administration Medical Center 2007 - 2008
  • PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health 2002 - 2008
  • Child Neglect: Psychobiological Consequences awarded by National Institutes of Health 2000 - 2007
  • same awarded by National Institutes of Health 1998 - 2005
  • Depression In Late Life awarded by National Institutes of Health 1995 - 1999
  • Depression In Late Life awarded by National Institutes of Health 1997 - 1999
  • Alzheimers Disease -- Antemortem Markers awarded by National Institutes of Health 1995 - 1999
  • Cortisol Cognition Brain Atrophy And Depression awarded by National Institutes of Health 1996 - 1998
  • Fluoxetine And Behavior Therapy In Social Phobia awarded by National Institutes of Health 1994 - 1998
  • Alzheimers Disease-- Antemortem Markers awarded by National Institutes of Health 1995 - 1998
• 

  External Relationships

  • Department of Veterans Affairs
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Morey, Rajendra A., Courtney C. Haswell, Daniel Stjepanović, Daniel Mid-Atlantic MIRECC Workgroup, Joseph E. Dunsmoor, and Kevin S. LaBar. “Neural correlates of conceptual-level fear generalization in posttraumatic stress disorder.” Neuropsychopharmacology 45, no. 8 (July 2020): 1380–89. https://doi.org/10.1038/s41386-020-0661-8.
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    • Shura, Robert D., Timothy W. Brearly, and Larry A. Tupler. “Telehealth in Response to the COVID-19 Pandemic in Rural Veteran and Military Beneficiaries.” The Journal of Rural Health : Official Journal of the American Rural Health Association and the National Rural Health Care Association, May 13, 2020. https://doi.org/10.1111/jrh.12454.
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    • Naylor, Jennifer C., H Ryan Wagner, Cynthia Johnston, Eric E. Elbogen, Mira Brancu, Christine E. Marx, Christine E. VA Mid-Atlantic MIRECC Work Group, Christine E. VA Mid-Atlantic MIRECC Women Veterans Work Group, and Jennifer L. Strauss. “Pain Intensity and Pain Interference in Male and Female Iraq/Afghanistan-era Veterans.” Womens Health Issues 29 Suppl 1 (June 25, 2019): S24–31. https://doi.org/10.1016/j.whi.2019.04.015.
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    • Shura, Robert D., Sarra Nazem, Holly M. Miskey, Trisha A. Hostetter, Jared A. Rowland, Lisa A. Brenner, Lisa A. Va Mid-Atlantic Mirecc Workgroup, and Katherine H. Taber. “Relationship between traumatic brain injury history and recent suicidal ideation in Iraq/Afghanistan-era veterans.” Psychol Serv 16, no. 2 (May 2019): 312–20. https://doi.org/10.1037/ser0000208.
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    • Sheerin, Christina M., Ananda B. Amstadter, Erin D. Kurtz, Kaitlin E. Bountress, Kelcey J. Stratton, Scott D. McDonald, and Scott D. Mid-Atlantic Va Mirecc Workgroup. “The association of resilience on psychiatric, substance use, and physical health outcomes in combat trauma-exposed military service members and veterans.” Eur J Psychotraumatol 10, no. 1 (2019): 1625700. https://doi.org/10.1080/20008198.2019.1625700.
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    • Martindale, Sarah L., Erica L. Epstein, Katherine H. Taber, Katherine H. VA Mid-Atlantic MIRECC Workgroup, and Jared A. Rowland. “Behavioral and Health Outcomes Associated With Deployment and Nondeployment Acquisition of Traumatic Brain Injury in Iraq and Afghanistan Veterans.” Arch Phys Med Rehabil 99, no. 12 (December 2018): 2485–95. https://doi.org/10.1016/j.apmr.2018.04.029.
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    • Swanson, Jeffrey, Michele Easter, Mira Brancu, Mira VA Mid-Atlantic MIRECC Workgroup, and John A. Fairbank. “Informing Federal Policy on Firearm Restrictions for Veterans with Fiduciaries: Risk Indicators in the Post-Deployment Mental Health Study.” Adm Policy Ment Health 45, no. 4 (July 2018): 673–83. https://doi.org/10.1007/s10488-018-0881-y.
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    • Wilson, Sarah M., Thomas K. Burroughs, Amie R. Newins, Eric A. Dedert, Alyssa M. Medenblik, Scott D. McDonald, Jean C. Beckham, Jean C. VA Mid-Atlantic MIRECC Workgroup, and Patrick S. Calhoun. “The Association Between Alcohol Consumption, Lifetime Alcohol Use Disorder, and Psychiatric Distress Among Male and Female Veterans.” J Stud Alcohol Drugs 79, no. 4 (July 2018): 591–600.
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    • Elbogen, Eric B., H Ryan Wagner, Nathan A. Kimbrel, Mira Brancu, Jennifer Naylor, Robert Graziano, Eric Crawford, and Eric VA Mid-Atlantic MIRECC Workgroup. “Risk factors for concurrent suicidal ideation and violent impulses in military veterans.” Psychol Assess 30, no. 4 (April 2018): 425–35. https://doi.org/10.1037/pas0000490.
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    • Sheerin, C. M., K. J. Stratton, A. B. Amstadter, S. D. McDonald, J. C. Beckham, M. Brancu, P. S. Calhoun, et al. “Exploring resilience models in a sample of combat-exposed military service members and veterans: a comparison and commentary.” European Journal of Psychotraumatology 9, no. 1 (January 1, 2018). https://doi.org/10.1080/20008198.2018.1486121.
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    • Sun, Delin, Sarah L. Davis, Courtney C. Haswell, Chelsea A. Swanson, Chelsea A. Mid-Atlantic MIRECC Workgroup, Kevin S. LaBar, John A. Fairbank, and Rajendra A. Morey. “Brain Structural Covariance Network Topology in Remitted Posttraumatic Stress Disorder.” Frontiers in Psychiatry 9 (January 2018): 90. https://doi.org/10.3389/fpsyt.2018.00090.
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    • Martindale, Sarah L., Leah V. Farrell-Carnahan, Christi S. Ulmer, Nathan A. Kimbrel, Scott D. McDonald, Jared A. Rowland, and Jared A. VA Mid-Atlantic MIRECC Registry Workgroup. “Sleep quality in returning veterans: The influence of mild traumatic brain injury.” Rehabil Psychol 62, no. 4 (November 2017): 563–70. https://doi.org/10.1037/rep0000159.
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    • Brancu, Mira, H Ryan Wagner, Rajendra A. Morey, Jean C. Beckham, Patrick S. Calhoun, Larry A. Tupler, Christine E. Marx, et al. “The Post-Deployment Mental Health (PDMH) study and repository: A multi-site study of US Afghanistan and Iraq era veterans.” Int J Methods Psychiatr Res 26, no. 3 (September 2017). https://doi.org/10.1002/mpr.1570.
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    • Naylor, Jennifer C., H. Ryan Wagner, Mira Brancu, Megan Shepherd-Banigan, Eric Elbogen, Michelle Kelley, Teresa Fecteau, et al. “Self-Reported Pain in Male and Female Iraq/Afghanistan-Era Veterans: Associations with Psychiatric Symptoms and Functioning.” Pain Med 18, no. 9 (September 1, 2017): 1658–67. https://doi.org/10.1093/pm/pnw308.
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    • Tupler, Larry A., Daniel Zapp, William DeJong, Maryam Ali, Sarah O’Rourke, John Looney, and H Scott Swartzwelder. “Alcohol-Related Blackouts, Negative Alcohol-Related Consequences, and Motivations for Drinking Reported by Newly Matriculating Transgender College Students.” Alcoholism, Clinical and Experimental Research 41, no. 5 (May 2017): 1012–23. https://doi.org/10.1111/acer.13358.
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    • Olbert, Charles M., Andrew Rasmussen, Gary J. Gala, and Larry A. Tupler. “Treatment outcome variation between depression symptom combinations in the STAR*D study.” J Affect Disord 201 (September 1, 2016): 1–7. https://doi.org/10.1016/j.jad.2016.04.050.
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    • Schry, Amie R., Jean C. Beckham, Jean C. The Va Mid-Atlantic Mirecc Workgroup, and Patrick S. Calhoun. “Sexual revictimization among Iraq and Afghanistan war era veterans.” Psychiatry Res 240 (June 30, 2016): 406–11. https://doi.org/10.1016/j.psychres.2016.04.016.
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    • Naylor, Jennifer C., Jason D. Kilts, Jennifer L. Strauss, Steven T. Szabo, Charlotte E. Dunn, H Ryan Wagner, Robert M. Hamer, et al. “An exploratory pilot investigation of neurosteroids and self-reported pain in female Iraq/Afghanistan-era Veterans.” J Rehabil Res Dev 53, no. 4 (2016): 499–510. https://doi.org/10.1682/JRRD.2014.11.0294.
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    • Naylor, Jennifer C., Jason D. Kilts, Steven T. Szabo, Charlotte E. Dunn, Francis J. Keefe, Larry A. Tupler, Lawrence J. Shampine, et al. “Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics.” Pain Med 17, no. 1 (January 2016): 25–32. https://doi.org/10.1111/pme.12860.
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    • Schry, Amie R., Rachel Hibberd, H Ryan Wagner, Jessica A. Turchik, Nathan A. Kimbrel, Madrianne Wong, Eric E. Elbogen, Jennifer L. Strauss, Jennifer L. Veterans Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center Workgroup, and Mira Brancu. “Functional correlates of military sexual assault in male veterans.” Psychol Serv 12, no. 4 (November 2015): 384–93. https://doi.org/10.1037/ser0000053.
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    • Kimbrel, Nathan A., Melanie E. Garrett, Michelle F. Dennis, Yutao Liu, Ilyas Patanam, Va Mid-Atlantic Mirecc Workgroup, Allison E. Ashley-Koch, Michael A. Hauser, and Jean C. Beckham. “Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder.” Psychiatry Res 229, no. 1–2 (September 30, 2015): 326–31. https://doi.org/10.1016/j.psychres.2015.07.002.
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    • Kelley, Michelle L., Mira Brancu, Allison T. Robbins, Gabrielle M. D’Lima, Jennifer L. Strauss, John F. Curry, John A. Fairbank, Jennifer Runnals, and Jennifer VA Mid-Atlantic MIRECC Women Veterans Workgroup, VA Mid-Atlantic MIRECC Workgroup. “Drug use and childhood-, military- and post-military trauma exposure among women and men veterans.” Drug Alcohol Depend 152 (July 1, 2015): 201–8. https://doi.org/10.1016/j.drugalcdep.2015.03.038.
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    • Tupler, Larry A., Jennifer Y. Hong, Ron Gibori, Timothy F. Blitchington, and K Ranga R. Krishnan. “Suicidal ideation and sex differences in relation to 18 major psychiatric disorders in college and university students: anonymous web-based assessment.” J Nerv Ment Dis 203, no. 4 (April 2015): 269–78. https://doi.org/10.1097/NMD.0000000000000277.
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    • Kimbrel, Nathan A., Patrick S. Calhoun, Eric B. Elbogen, Mira Brancu, Mira VA Mid-Atlantic MIRECC Registry Workgroup, and Jean C. Beckham. “The factor structure of psychiatric comorbidity among Iraq/Afghanistan-era veterans and its relationship to violence, incarceration, suicide attempts, and suicidality.” Psychiatry Res 220, no. 1–2 (December 15, 2014): 397–403. https://doi.org/10.1016/j.psychres.2014.07.064.
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    • Gentes, Emily L., Paul A. Dennis, Nathan A. Kimbrel, Michelle B. Rissling, Jean C. Beckham, Jean C. VA Mid-Atlantic MIRECC Workgroup, and Patrick S. Calhoun. “DSM-5 posttraumatic stress disorder: factor structure and rates of diagnosis.” J Psychiatr Res 59 (December 2014): 60–67. https://doi.org/10.1016/j.jpsychires.2014.08.014.
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    • Guffanti, G., A. E. Ashley-Koch, A. L. Roberts, M. E. Garrett, N. Solovieff, A. Ratanatharathorn, I. De Vivo, et al. “No association between RORA polymorphisms and PTSD in two independent samples.” Mol Psychiatry 19, no. 10 (October 2014): 1056–57. https://doi.org/10.1038/mp.2014.19.
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    • Brancu, Mira, Nivonne L. Thompson, Jean C. Beckham, Kimberly T. Green, Patrick S. Calhoun, Eric B. Elbogen, Allison T. Robbins, John A. Fairbank, John A. VA Mid-Atlantic MIRECC Registry Workgroup, and H Ryan Wagner. “The impact of social support on psychological distress for U.S. Afghanistan/Iraq era veterans with PTSD and other psychiatric diagnoses.” Psychiatry Res 217, no. 1–2 (June 30, 2014): 86–92. https://doi.org/10.1016/j.psychres.2014.02.025.
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    • Olbert, Charles M., Gary J. Gala, and Larry A. Tupler. “Quantifying heterogeneity attributable to polythetic diagnostic criteria: theoretical framework and empirical application.” J Abnorm Psychol 123, no. 2 (May 2014): 452–62. https://doi.org/10.1037/a0036068.
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    • Szabo, Steven T., Jason D. Kilts, Jennifer C. Naylor, Nagy A. Youssef, Jennifer L. Strauss, Rajendra A. Morey, Mira Brancu, et al. “Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling.” Mil Med 179, no. 5 (May 2014): 486–91. https://doi.org/10.7205/MILMED-D-13-00337.
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    • Brown, Vanessa M., Kevin S. LaBar, Courtney C. Haswell, Andrea L. Gold, Andrea L. Mid-Atlantic MIRECC Workgroup, Gregory McCarthy, and Rajendra A. Morey. “Altered resting-state functional connectivity of basolateral and centromedial amygdala complexes in posttraumatic stress disorder.” Neuropsychopharmacology 39, no. 2 (January 2014): 351–59. https://doi.org/10.1038/npp.2013.197.
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    • Kaber, David, Larry A. Tupler, Michael Clamann, Guk-Ho Gil, Biwen Zhu, Manida Swangnetr, Wooram Jeon, et al. “Evaluation of an augmented virtual reality and haptic control interface for psychomotor training.” Assist Technol 26, no. 1 (2014): 51–60. https://doi.org/10.1080/10400435.2013.800923.
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    • McCormick, Cortney L., Ruth E. Yoash-Gantz, Scott D. McDonald, Thomas C. Campbell, and Larry A. Tupler. “Performance on the Green Word Memory Test following Operation Enduring Freedom/Operation Iraqi Freedom-era military service: Test failure is related to evaluation context.” Arch Clin Neuropsychol 28, no. 8 (December 2013): 808–23. https://doi.org/10.1093/arclin/act050.
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    • Morey, Rajendra A., Courtney C. Haswell, Elizabeth S. Selgrade, Dino Massoglia, Chunlei Liu, Jonathan Weiner, Christine E. Marx, Christine E. MIRECC Work Group, Ibolja Cernak, and Gregory McCarthy. “Effects of chronic mild traumatic brain injury on white matter integrity in Iraq and Afghanistan war veterans.” Hum Brain Mapp 34, no. 11 (November 2013): 2986–99. https://doi.org/10.1002/hbm.22117.
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    • Swinkels, C. M., C. S. Ulmer, J. C. Beckham, N. Buse, P. S. Calhoun, J. A. Fairbank, C. E. Marx, et al. “The association of sleep duration, mental health, and health risk behaviors among U.S. Afghanistan/Iraq era veterans.” Sleep 36, no. 7 (July 1, 2013): 1019–25. https://doi.org/10.5665/sleep.2800.
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    • Perlick, Deborah A., Kristy Straits-Troster, Jennifer L. Strauss, Diane Norell, Larry A. Tupler, Bruce Levine, Xiaodong Luo, et al. “Implementation of multifamily group treatment for veterans with traumatic brain injury.” Psychiatr Serv 64, no. 6 (June 2013): 534–40. https://doi.org/10.1176/appi.ps.001622012.
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    • Hayes, Jasmeet Pannu, Rajendra A. Morey, and Larry A. Tupler. “A case of frontal neuropsychological and neuroimaging signs following multiple primary-blast exposure.” Neurocase 18, no. 3 (June 2012): 258–69. https://doi.org/10.1080/13554794.2011.588181.
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    • Li, Y., D. B. Kaber, L. Tupler, and Y. S. Lee. “Haptic-based virtual environment design and modeling of motor skill assessment for Brain Injury PatientsRehabilitation.” Computer Aided Design and Applications 8, no. 2 (August 5, 2011): 149–62. https://doi.org/10.3722/cadaps.2011.149-162.
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    • Montella, Diane, Steven H. Brown, Peter L. Elkin, James C. Jackson, S Trent Rosenbloom, Dietlind Wahner-Roedler, Gail Welsh, et al. “Comparison of SNOMED CT versus Medcin terminology concept coverage for mild Traumatic Brain Injury.” Amia Annu Symp Proc 2011 (2011): 969–78.
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    • Kilts, Jason D., Larry A. Tupler, Francis J. Keefe, Victoria M. Payne, Robert M. Hamer, Jennifer C. Naylor, Rohana P. Calnaido, et al. “Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001.” Pain Med 11, no. 10 (October 2010): 1469–76. https://doi.org/10.1111/j.1526-4637.2010.00927.x.
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    • Elbogen, Eric B., H Ryan Wagner, Sara R. Fuller, Patrick S. Calhoun, Patricia M. Kinneer, Patricia M. Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, and Jean C. Beckham. “Correlates of anger and hostility in Iraq and Afghanistan war veterans.” Am J Psychiatry 167, no. 9 (September 2010): 1051–58. https://doi.org/10.1176/appi.ajp.2010.09050739.
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    • Green, Kimberly T., Patrick S. Calhoun, Michelle F. Dennis, Michelle F. Mid-Atlantic Mental Illness Research, Education and Clinical Center Workgroup, and Jean C. Beckham. “Exploration of the resilience construct in posttraumatic stress disorder severity and functional correlates in military combat veterans who have served since September 11, 2001.” J Clin Psychiatry 71, no. 7 (July 2010): 823–30. https://doi.org/10.4088/JCP.09m05780blu.
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    • Dedert, Eric A., Kimberly T. Green, Patrick S. Calhoun, Ruth Yoash-Gantz, Katherine H. Taber, Marinell Miller Mumford, Larry A. Tupler, et al. “Association of trauma exposure with psychiatric morbidity in military veterans who have served since September 11, 2001.” J Psychiatr Res 43, no. 9 (June 2009): 830–36. https://doi.org/10.1016/j.jpsychires.2009.01.004.
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    • Belanger, Heather G., Tracy Kretzmer, Ruth Yoash-Gantz, Treven Pickett, and Larry A. Tupler. “Cognitive sequelae of blast-related versus other mechanisms of brain trauma.” J Int Neuropsychol Soc 15, no. 1 (January 2009): 1–8. https://doi.org/10.1017/S1355617708090036.
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    • McDonald, Scott D., Jean C. Beckham, Rajendra Morey, Christine Marx, Larry A. Tupler, and Patrick S. Calhoun. “Factorial invariance of posttraumatic stress disorder symptoms across three veteran samples.” J Trauma Stress 21, no. 3 (June 2008): 309–17. https://doi.org/10.1002/jts.20344.
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    • Skotko, Brian G., David C. Rubin, and Larry A. Tupler. “H.M.'s personal crossword puzzles: understanding memory and language.” Memory 16, no. 2 (February 2008): 89–96. https://doi.org/10.1080/09658210701864580.
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    • Jackson, George L., Natia S. Hamilton, and Larry A. Tupler. “Detecting traumatic brain injury among veterans of Operations Enduring and Iraqi Freedom.” N C Med J 69, no. 1 (January 2008): 43–47.
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    • Hidalgo, Rosario B., Larry A. Tupler, and Jonathan R. T. Davidson. “An effect-size analysis of pharmacologic treatments for generalized anxiety disorder.” J Psychopharmacol 21, no. 8 (November 2007): 864–72. https://doi.org/10.1177/0269881107076996.
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    • Tupler, Larry A., K Ranga R. Krishnan, Daniel L. Greenberg, Santica M. Marcovina, Martha E. Payne, James R. MacFall, H Cecil Charles, and P Murali Doraiswamy. “Predicting memory decline in normal elderly: genetics, MRI, and cognitive reserve.” Neurobiol Aging 28, no. 11 (November 2007): 1644–56. https://doi.org/10.1016/j.neurobiolaging.2006.07.001.
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    • Tupler, Larry A., and Michael D. De Bellis. “Segmented hippocampal volume in children and adolescents with posttraumatic stress disorder.” Biol Psychiatry 59, no. 6 (March 15, 2006): 523–29. https://doi.org/10.1016/j.biopsych.2005.08.007.
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    • Greenwood, Robert S., Larry A. Tupler, J Kenneth Whitt, Anne Buu, Carrie B. Dombeck, Amanda G. Harp, Martha E. Payne, James D. Eastwood, K Ranga R. Krishnan, and James R. MacFall. “Brain morphometry, T2-weighted hyperintensities, and IQ in children with neurofibromatosis type 1.” Arch Neurol 62, no. 12 (December 2005): 1904–8. https://doi.org/10.1001/archneur.62.12.1904.
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    • Skotko, Brian G., Elizabeth A. Kensinger, Joseph J. Locascio, Gillian Einstein, David C. Rubin, Larry A. Tupler, Anne Krendl, and Suzanne Corkin. “Puzzling thoughts for H. M.: can new semantic information be anchored to old semantic memories?” Neuropsychology 18, no. 4 (October 2004): 756–69. https://doi.org/10.1037/0894-4105.18.4.756.
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    • Vythilingam, Meena, H Cecil Charles, Larry A. Tupler, Timothy Blitchington, Lisalynn Kelly, and K Ranga Rama Krishnan. “Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study.” Biol Psychiatry 54, no. 7 (October 1, 2003): 744–50. https://doi.org/10.1016/s0006-3223(02)01908-x.
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    • Tupler, Larry A., K Ranga R. Krishnan, William M. McDonald, Carrie B. Dombeck, Sean D’Souza, and David C. Steffens. “Anatomic location and laterality of MRI signal hyperintensities in late-life depression.” J Psychosom Res 53, no. 2 (August 2002): 665–76. https://doi.org/10.1016/s0022-3999(02)00425-7.
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    • Kim, Dennis M., Stavra A. Xanthakos, Larry A. Tupler, Daniel P. Barboriak, H Cecil Charles, James R. MacFall, and K Ranga Rama Krishnan. “MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex.” Psychiatry Res 114, no. 3 (July 1, 2002): 149–61. https://doi.org/10.1016/s0925-4927(02)00024-0.
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    • Steffens, D. C., C. R. Conway, C. B. Dombeck, H. R. Wagner, L. A. Tupler, and R. D. Weiner. “Severity of subcortical gray matter hyperintensity predicts ECT response in geriatric depression.” J Ect 17, no. 1 (March 2001): 45–49. https://doi.org/10.1097/00124509-200103000-00009.
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    • Connor, K. M., S. M. Sutherland, L. A. Tupler, M. L. Malik, and J. R. Davidson. “Fluoxetine in post-traumatic stress disorder. Randomised, double-blind study.” Br J Psychiatry 175 (July 1999): 17–22. https://doi.org/10.1192/bjp.175.1.17.
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    • McDonald, W. M., L. A. Tupler, F. A. Marsteller, G. S. Figiel, S. DiSouza, C. B. Nemeroff, and K. R. Krishnan. “Hyperintense lesions on magnetic resonance images in bipolar disorder.” Biol Psychiatry 45, no. 8 (April 15, 1999): 965–71. https://doi.org/10.1016/s0006-3223(98)00341-2.
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    • Madden, D. J., K. A. Welsh-Bohmer, and L. A. Tupler. “Task complexity and signal detection analyses of lexical decision performance in Alzheimer's disease.” Developmental Neuropsychology 16, no. 1 (January 1, 1999): 1–18. https://doi.org/10.1207/S15326942DN160101.
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    • Parashos, I. A., L. A. Tupler, T. Blitchington, and K. R. Krishnan. “Magnetic-resonance morphometry in patients with major depression.” Psychiatry Res 84, no. 1 (November 9, 1998): 7–15. https://doi.org/10.1016/s0925-4927(98)00042-0.
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    • Clark, L. M., W. M. McDonald, K. A. Welsh-Bohmer, I. C. Siegler, D. V. Dawson, L. A. Tupler, and K. R. Krishnan. “Magnetic resonance imaging correlates of depression in early- and late-onset Alzheimer's disease.” Biol Psychiatry 44, no. 7 (October 1, 1998): 592–99. https://doi.org/10.1016/s0006-3223(98)00106-1.
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    • Connor, K. M., J. R. Davidson, N. L. Potts, L. A. Tupler, C. M. Miner, M. L. Malik, S. W. Book, J. T. Colket, and F. Ferrell. “Discontinuation of clonazepam in the treatment of social phobia.” J Clin Psychopharmacol 18, no. 5 (October 1998): 373–78. https://doi.org/10.1097/00004714-199810000-00004.
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    • Davidson, J. R., L. A. Tupler, W. H. Wilson, and K. M. Connor. “A family study of chronic post-traumatic stress disorder following rape trauma.” J Psychiatr Res 32, no. 5 (September 1998): 301–9. https://doi.org/10.1016/S0022-3956(98)00016-8.
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    • Steffens, D. C., L. A. Tupler, K. Ranga, and R. Krishnan. “Magnetic resonance imaging signal hypointensity and iron content of putamen nuclei in elderly depressed patients.” Psychiatry Res 83, no. 2 (August 26, 1998): 95–103. https://doi.org/10.1016/s0925-4927(98)00032-8.
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    • Lazeyras, F., H. C. Charles, L. A. Tupler, R. Erickson, O. B. Boyko, and K. R. Krishnan. “Metabolic brain mapping in Alzheimer's disease using proton magnetic resonance spectroscopy.” Psychiatry Res 82, no. 2 (May 20, 1998): 95–106. https://doi.org/10.1016/s0925-4927(98)00010-9.
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    • Davidson, J. R., R. H. Weisler, M. Malik, and L. A. Tupler. “Fluvoxamine in civilians with posttraumatic stress disorder.” J Clin Psychopharmacol 18, no. 1 (February 1998): 93–95. https://doi.org/10.1097/00004714-199802000-00020.
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    • Passe, T. J., P. Rajagopalan, L. A. Tupler, C. E. Byrum, J. R. MacFall, and K. R. Krishnan. “Age and sex effects on brain morphology.” Prog Neuropsychopharmacol Biol Psychiatry 21, no. 8 (November 1997): 1231–37. https://doi.org/10.1016/s0278-5846(97)00160-7.
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    • Tupler, L. A., J. R. Davidson, R. D. Smith, F. Lazeyras, H. C. Charles, and K. R. Krishnan. “A repeat proton magnetic resonance spectroscopy study in social phobia.” Biol Psychiatry 42, no. 6 (September 15, 1997): 419–24. https://doi.org/10.1016/S0006-3223(96)00501-X.
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    • Greenwood, R. S., S. M. Said, T. L. Yeh, M. A. ElFatatry, L. A. Tupler, and K. R. K. Krishnan. “Changes in brain volume in children with neurofibromatosis 1.” Annals of Neurology 42, no. 3 (September 1, 1997): P4–P4.
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    • Escalona, R., L. A. Tupler, C. D. Saur, K. R. Krishnan, and J. R. Davidson. “Screening for trauma history on an inpatient affective-disorders unit: a pilot study.” J Trauma Stress 10, no. 2 (April 1997): 299–305. https://doi.org/10.1023/a:1024886314370.
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    • Krishnan, K Ranga Rama, and Larry A. Tupler. “Response.” Biological Psychiatry 41, no. 8 (April 1997): 912–13. https://doi.org/10.1016/s0006-3223(97)00020-6.
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    • Davidson, J. R., C. M. Miner, J. De Veaugh-Geiss, L. A. Tupler, J. T. Colket, and N. L. Potts. “The Brief Social Phobia Scale: a psychometric evaluation.” Psychol Med 27, no. 1 (January 1997): 161–66. https://doi.org/10.1017/s0033291796004217.
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    • Davidson, J. R., S. W. Book, J. T. Colket, L. A. Tupler, S. Roth, D. David, M. Hertzberg, et al. “Assessment of a new self-rating scale for post-traumatic stress disorder.” Psychol Med 27, no. 1 (January 1997): 153–60. https://doi.org/10.1017/s0033291796004229.
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    • Sutherland, S. M., L. A. Tupler, J. T. Colket, and J. R. Davidson. “A 2-year follow-up of social phobia. Status after a brief medication trial.” J Nerv Ment Dis 184, no. 12 (December 1996): 731–38. https://doi.org/10.1097/00005053-199612000-00003.
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    • Steffens, D. C., W. M. McDonald, L. A. Tupler, O. B. Boyko, and K. R. Krishnan. “Magnetic resonance imaging changes in putamen nuclei iron content and distribution in normal subjects.” Psychiatry Res 68, no. 1 (November 25, 1996): 55–61. https://doi.org/10.1016/0925-4927(96)02834-x.
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    • Said, S. M., T. L. Yeh, R. S. Greenwood, J. K. Whitt, L. A. Tupler, and K. R. Krishnan. “MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis.” Neuroreport 7, no. 12 (August 12, 1996): 1941–44. https://doi.org/10.1097/00001756-199608120-00015.
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    • Said, S. M., T. L. Yeh, M. A. ElFatatry, R. S. Greenwood, J. K. Whitt, N. Frank, L. A. Tupler, K. Ranga, and K. Krishnan. “Magnetic resonance imaging morphometric indices as predictive markers for learning disabilities in children with neuofibromatosis-1.” Annals of Neurology 40, no. 2 (August 1, 1996): 149–149.
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    • Krishnan, K. R., L. A. Tupler, J. C. Ritchie, W. M. McDonald, D. L. Knight, C. B. Nemeroff, and B. J. Carroll. “Apolipoprotein E-epsilon 4 frequency in geriatric depression.” Biol Psychiatry 40, no. 1 (July 1, 1996): 69–71. https://doi.org/10.1016/0006-3223(95)00424-6.
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    • Charles, H. C., F. Lazeyras, L. A. Tupler, and K. R. Krishnan. “Reproducibility of high spatial resolution proton magnetic resonance spectroscopic imaging in the human brain.” Magn Reson Med 35, no. 4 (April 1996): 606–10. https://doi.org/10.1002/mrm.1910350422.
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    • Tupler, L. A., K. R. R. Krishnan, J. C. Ritchie, W. M. McDonald, D. L. Knight, C. B. Nemeroff, and B. J. Carroll. “Cognitive impairment in elderly depressed individuals with APOE epsilon 4.” Biological Psychiatry 39, no. 7 (April 1, 1996): 539–539.
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    • Miner, C. M., J. R. Davidson, N. L. Potts, L. A. Tupler, H. C. Charles, and K. R. Krishnan. “Brain fluoxetine measurements using fluorine magnetic resonance spectroscopy in patients with social phobia.” Biol Psychiatry 38, no. 10 (November 15, 1995): 696–98. https://doi.org/10.1016/0006-3223(95)00287-1.
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    • Tupler, L. A., K. A. Welsh, Y. Asare-Aboagye, and D. V. Dawson. “Reliability of the Rey-Osterrieth Complex Figure in use with memory-impaired patients.” J Clin Exp Neuropsychol 17, no. 4 (August 1995): 566–79. https://doi.org/10.1080/01688639508405146.
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    • Krishnan, K. R., J. C. Hays, L. A. Tupler, L. K. George, and D. G. Blazer. “Clinical and phenomenological comparisons of late-onset and early-onset depression.” Am J Psychiatry 152, no. 5 (May 1995): 785–88. https://doi.org/10.1176/ajp.152.5.785.
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    • Tupler, L. A., S. Hege, and E. H. Ellinwood. “Alcohol pharmacodynamics in young-elderly adults contrasted with young and middle-aged subjects.” Psychopharmacology (Berl) 118, no. 4 (April 1995): 460–70. https://doi.org/10.1007/BF02245947.
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    • Doraiswamy, P. M., L. A. Tupler, and K. R. Krishnan. “Neuroleptic treatment and caudate plasticity.” Lancet 345, no. 8951 (March 18, 1995): 734–35.
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    • Krishnan, K. R., L. A. Tupler, and W. M. McDonald. “Background factors and clinical symptoms of major depression with silent cerebral infarction.” Stroke 25, no. 12 (December 1994): 2507.
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    • Rama Krishnan, K. R., J. C. Ritchie, L. A. Tupler, W. M. McDonald, D. Knight, C. B. Nemeroff, and S. Marcovina. “Apolipoprotein E epsilon 4.” Neurology 44, no. 12 (December 1994): 2420–21. https://doi.org/10.1212/wnl.44.12.2420-a.
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    • Halpern, S. D., P. M. Doraiswamy, L. A. Tupler, J. M. Holland, S. M. Ford, and E. H. Ellinwood. “Emergency department patterns in psychiatric visits during the holiday season.” Ann Emerg Med 24, no. 5 (November 1994): 939–43. https://doi.org/10.1016/s0196-0644(94)70210-1.
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    • Davidson, J. R., L. A. Tupler, and N. L. Potts. “Treatment of social phobia with benzodiazepines.” J Clin Psychiatry 55 Suppl (June 1994): 28–32.
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    • Sakoda, S., M. Kuriyama, M. Osame, K. Takahashi, T. Yamano, J. Sasaki, and A. Matsunaga. “Apolipoprotein E ε4.” Neurology 44, no. 12 (January 1, 1994): 2420. https://doi.org/10.1212/WNL.44.12.2420.
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    • Krishnan, K. R., W. M. McDonald, and L. A. Tupler. “Neuropathology in affective illness.” Am J Psychiatry 150, no. 10 (October 1993): 1568–69. https://doi.org/10.1176/ajp.150.10.1568b.
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    • Axelson, D. A., P. M. Doraiswamy, W. M. McDonald, O. B. Boyko, L. A. Tupler, L. J. Patterson, C. B. Nemeroff, E. H. Ellinwood, and K. R. Krishnan. “Hypercortisolemia and hippocampal changes in depression.” Psychiatry Res 47, no. 2 (May 1993): 163–73. https://doi.org/10.1016/0165-1781(93)90046-j.
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    • Davidson, J. R. T., N. Potts, R. Krishnan, O. Boyko, C. Charles, R. Smith, S. Ford, L. A. Tupler, and W. Wilson. “Biology of social phobia.” European Neuropsychopharmacology 3, no. 3 (January 1, 1993): 192–93. https://doi.org/10.1016/0924-977X(93)90019-I.
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    • Krishnan, K. R. R., O. B. Boyko, W. M. McDonald, H. C. Charles, J. R. Macfall, L. A. Tupler, and L. W. Upchurch. “Magnetic‐resonance morphometry: Image‐analysis methodology development for affective disorder.” Depression 1, no. 3 (January 1, 1993): 159–71. https://doi.org/10.1002/depr.3050010308.
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    • Krishnan, K. R., W. M. McDonald, P. M. Doraiswamy, L. A. Tupler, M. Husain, O. B. Boyko, G. S. Figiel, and E. H. Ellinwood. “Neuroanatomical substrates of depression in the elderly.” Eur Arch Psychiatry Clin Neurosci 243, no. 1 (1993): 41–46. https://doi.org/10.1007/BF02191522.
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    • Logue, P. E., L. A. Tupler, C. D’Amico, and F. A. Schmitt. “The Neurobehavioral Cognitive Status Examination: psychometric properties in use with psychiatric inpatients.” J Clin Psychol 49, no. 1 (January 1993): 80–89. https://doi.org/10.1002/1097-4679(199301)49:1<80::aid-jclp2270490111>3.0.co;2-z.
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    • Steffens, D. C., L. A. Tupler, and K. R. R. Krishnan. “The neurostructural/neurofunctional basis of depression/mania.” Current Opinion in Psychiatry 6, no. 1 (January 1, 1993): 22–26. https://doi.org/10.1097/00001504-199302000-00005.
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    • Tupler, L. A., C. E. Coffey, P. E. Logue, W. T. Djang, and S. M. Fagan. “Neuropsychological importance of subcortical white matter hyperintensity.” Arch Neurol 49, no. 12 (December 1992): 1248–52. https://doi.org/10.1001/archneur.1992.00530360046016.
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    • Freides, D., L. A. Tupler, J. M. Hall, and T. E. Fowler. “On the independence of physical and nominal codes: a correlational analysis.” Brain Cogn 8, no. 3 (December 1988): 409–20. https://doi.org/10.1016/0278-2626(88)90061-9.
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    • Stiles, W. B., L. A. Tupler, and J. C. Carpenter. “Participants' perceptions of self-analytic group sessions.” Small Group Research 13, no. 2 (January 1, 1982): 237–54. https://doi.org/10.1177/104649648201300208.
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  • Book Sections

    • Marx, C. E., J. C. Naylor, J. D. Kilts, C. E. Dunn, L. A. Tupler, S. T. Szabo, B. P. Capehart, R. A. Morey, L. J. Shampine, and S. K. Acheson. “Neurosteroids and traumatic brain injury translating biomarkers to therapeutics; overview and pilot investigations in Iraq and Afghanistan era veterans.” In Translational Research in Traumatic Brain Injury, 145–61, 2016.
    • Clamann, M., G. H. Gil, D. Kaber, B. Zhu, M. Swangnetr, W. Jeon, Y. Zhang, et al. “Assessment of a virtual reality-based haptic simulation for motor skill training.” In Advances in Human Aspects of Healthcare, 515–24, 2012. https://doi.org/10.1201/b12318.
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  • Conference Papers

    • Nayllor, Jennifer C., Victoria M. Payne, Patrick S. Calhoun, Rajendra A. Morey, Jean C. Beckham, Larry A. Tupler, Gary E. Duncan, Lawrence J. Shampine, Jason D. Kilts, and Christine E. Marx. “L-serine predicts self-reported pain in female OEF/OIF veterans.” In Biological Psychiatry, 63:218S-218S, 2008.
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    • Payne, Victoria M., Rajendra A. Morey, Robert M. Hamer, Larry A. Tupler, Patrick S. Calhoun, Jean C. Beckham, Lawrence J. Shampine, et al. “Neuroactive steroids are related to psychiatric symptoms in veterans returning from iraq and Afghanistan.” In Biological Psychiatry, 61:130S-131S, 2007.
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    • Greenwood, R. S., E. McPhail, J. D. Eastwood, S. M. Kealey, J. R. MacFall, L. A. Tupler, A. G. Harp, A. Buu, and K. Ranga. “Focal and diffuse T2-weighted hyperintensities in neurofibromatosis type 1 (NF1).” In Annals of Neurology, 60:S155–56. WILEY-LISS, 2006.
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• Teaching & Mentoring
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  Recent Courses

  • NEUROSCI 493: Research Independent Study 1 2019

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