Larry A. Tupler | Scholars@Duke

Larry A. Tupler
Associate Professor in Psychiatry and Behavioral Sciences

My principal research interest concerns brain-behavior relationships, both in
normals and in psychiatric populations. Methods of study include magnetic
resonance imaging (MRI) and spectroscopy (MRS), neuropsychological
investigations, psychopharmacological studies, cognitive-science paradigms,
and methodological inquiries. More specifically, topics of interest include
lesion and morphometric studies of discrete brain regions as they relate to
cognitive and other behavioral measures, pharmacodynamics, pharmacotherapy,
and psychometric investigations of reliability and validity. Gerontological
populations are of particular interest in relation to both normal and abnormal
aging, particularly dementia (e.g., Alzheimer's disease and vascular
dementia). Psychiatric disorders of particular interest include mood and
anxiety disorders.

Current Appointments & Affiliations

Associate Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Translational Neuroscience, Psychiatry & Behavioral Sciences 2014
Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2011

Contact Information

4071B Hosp South, Durham, NC 27710
Box 3018 Med Ctr, Durham, NC 27710
tuple001@duke.edu (919) 684-4921

Background
Education, Training, & Certifications
- Ph.D., Emory University 1989
Duke Appointment History
- Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Translational Neuroscience, Psychiatry & Behavioral Sciences 2013 - 2014
- Assistant Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 2007 - 2013
- Assistant Clinical Professor of Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 2006 - 2007
- Assistant Research Professor in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 1997 - 2006
- Clinical Associate in Psychiatry and Behavioral Sciences, Psychiatry & Behavioral Sciences, Medical Psychology, Psychiatry & Behavioral Sciences 1994 - 1997
Research
Selected Grants
- IPA - Larry Allen Tupler awarded by Durham Veterans Affairs Medical Center 2018 - 2020
- FMRI Assessment of Attention and Memory in PTSD awarded by National Institutes of Health 2006 - 2012
- Neuroimaging of Trauma Memory and Cognitive Reappraisal in PTSD awarded by National Institutes of Health 2009
- IPA-Larry Tupler awarded by Veterans Administration Medical Center 2007 - 2008
- PTSD & Childhood Sexual Abuse: Psychobiology awarded by National Institutes of Health 2002 - 2008
- Child Neglect: Psychobiological Consequences awarded by National Institutes of Health 2000 - 2007
- Brain Structure and Cognition in Elderly with APOE E4 awarded by National Institutes of Health 1998 - 2005
- Depression In Late Life awarded by National Institutes of Health 1995 - 1999
- Depression In Late Life awarded by National Institutes of Health 1997 - 1999
- Alzheimers Disease -- Antemortem Markers awarded by National Institutes of Health 1995 - 1999
- Cortisol Cognition Brain Atrophy And Depression awarded by National Institutes of Health 1996 - 1998
- Fluoxetine And Behavior Therapy In Social Phobia awarded by National Institutes of Health 1994 - 1998
- Alzheimers Disease-- Antemortem Markers awarded by National Institutes of Health 1995 - 1998
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Martindale, SL, Epstein, EL, Taber, KH, VA Mid-Atlantic MIRECC Workgroup, , and Rowland, JA. "Behavioral and Health Outcomes Associated With Deployment and Nondeployment Acquisition of Traumatic Brain Injury in Iraq and Afghanistan Veterans." Archives of Physical Medicine and Rehabilitation 99, no. 12 (December 2018): 2485-2495. Full Text
  - Wilson, SM, Burroughs, TK, Newins, AR, Dedert, EA, Medenblik, AM, McDonald, SD, Beckham, JC, VA Mid-Atlantic MIRECC Workgroup, , and Calhoun, PS. "The Association Between Alcohol Consumption, Lifetime Alcohol Use Disorder, and Psychiatric Distress Among Male and Female Veterans." Journal of Studies on Alcohol and Drugs 79, no. 4 (July 2018): 591-600.
  - Swanson, J, Easter, M, Brancu, M, VA Mid-Atlantic MIRECC Workgroup, , and Fairbank, JA. "Informing Federal Policy on Firearm Restrictions for Veterans with Fiduciaries: Risk Indicators in the Post-Deployment Mental Health Study." Administration and Policy in Mental Health (May 24, 2018). Full Text
  - Sun, D, Davis, SL, Haswell, CC, Swanson, CA, Mid-Atlantic MIRECC Workgroup, , LaBar, KS, Fairbank, JA, and Morey, RA. "Brain Structural Covariance Network Topology in Remitted Posttraumatic Stress Disorder." Frontiers in Psychiatry 9 (January 2018): 90-null. Full Text
  - Martindale, SL, Farrell-Carnahan, LV, Ulmer, CS, Kimbrel, NA, McDonald, SD, Rowland, JA, and VA Mid-Atlantic MIRECC Registry Workgroup, . "Sleep quality in returning veterans: The influence of mild traumatic brain injury." Rehabilitation Psychology 62, no. 4 (November 2017): 563-570. Full Text
  - Brancu, M, Wagner, HR, Morey, RA, Beckham, JC, Calhoun, PS, Tupler, LA, Marx, CE, Taber, KH, Hurley, RA, Rowland, J, McDonald, SD, Hoerle, JM, Moore, SD, Kudler, HS, Weiner, RD, VA Mid-Atlantic MIRECC Workgroup, , and Fairbank, JA. "The Post-Deployment Mental Health (PDMH) study and repository: A multi-site study of US Afghanistan and Iraq era veterans." International Journal of Methods in Psychiatric Research 26, no. 3 (September 2017). Full Text
  - Naylor, JC, Ryan Wagner, H, Brancu, M, Shepherd-Banigan, M, Elbogen, E, Kelley, M, Fecteau, T, Goldstein, K, Kimbrel, NA, Marx, CE, VA Mid-Atlantic MIRECC Work Group, , VA Mid-Atlantic MIRECC Women Veterans Work Group, , and Strauss, JL. "Self-Reported Pain in Male and Female Iraq/Afghanistan-Era Veterans: Associations with Psychiatric Symptoms and Functioning." Pain medicine (Malden, Mass.) 18, no. 9 (September 2017): 1658-1667. Full Text
  - Elbogen, EB, Wagner, HR, Kimbrel, NA, Brancu, M, Naylor, J, Graziano, R, Crawford, E, and VA Mid-Atlantic MIRECC Workgroup, . "Risk Factors for Concurrent Suicidal Ideation and Violent Impulses in Military Veterans." Psychological assessment (June 19, 2017). Full Text
  - Tupler, LA, Zapp, D, DeJong, W, Ali, M, O'Rourke, S, Looney, J, and Swartzwelder, HS. "Alcohol-Related Blackouts, Negative Alcohol-Related Consequences, and Motivations for Drinking Reported by Newly Matriculating Transgender College Students." Alcoholism, clinical and experimental research 41, no. 5 (May 2017): 1012-1023. Full Text
  - Olbert, CM, Rasmussen, A, Gala, GJ, and Tupler, LA. "Treatment outcome variation between depression symptom combinations in the STAR*D study." Journal of Affective Disorders 201 (September 2016): 1-7. Full Text
  - Schry, AR, Beckham, JC, The Va Mid-Atlantic Mirecc Workgroup, , and Calhoun, PS. "Sexual revictimization among Iraq and Afghanistan war era veterans." Psychiatry Research 240 (June 2016): 406-411. Full Text
  - Naylor, JC, Kilts, JD, Strauss, JL, Szabo, ST, Dunn, CE, Wagner, HR, Hamer, RM, Shampine, LJ, Zanga, JR, Marx, CE, Department of Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and and Clinical Center Workgroup, . "An exploratory pilot investigation of neurosteroids and self-reported pain in female Iraq/Afghanistan-era Veterans." Journal of Rehabilitation Research and Development 53, no. 4 (January 2016): 499-510. Full Text
  - Naylor, JC, Kilts, JD, Szabo, ST, Dunn, CE, Keefe, FJ, Tupler, LA, Shampine, LJ, Morey, RA, Strauss, JL, Hamer, RM, Wagner, HR, MIRECC Workgroup, , and Marx, CE. "Allopregnanolone Levels Are Inversely Associated with Self-Reported Pain Symptoms in U.S. Iraq and Afghanistan-Era Veterans: Implications for Biomarkers and Therapeutics." Pain Medicine (Malden, Mass.) 17, no. 1 (January 2016): 25-32. Full Text Open Access Copy
  - Schry, AR, Hibberd, R, Wagner, HR, Turchik, JA, Kimbrel, NA, Wong, M, Elbogen, EE, Strauss, JL, Veterans Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center Workgroup, , and Brancu, M. "Functional correlates of military sexual assault in male veterans." Psychological Services 12, no. 4 (November 2015): 384-393. Full Text
  - Kimbrel, NA, Garrett, ME, Dennis, MF, Liu, Y, Patanam, I, Workgroup, VM-AM, Ashley-Koch, AE, Hauser, MA, and Beckham, JC. "Effect of genetic variation in the nicotinic receptor genes on risk for posttraumatic stress disorder." Psychiatry research 229, no. 1-2 (September 2015): 326-331. Full Text
  - Kelley, ML, Brancu, M, Robbins, AT, D'Lima, GM, Strauss, JL, Curry, JF, Fairbank, JA, Runnals, J, VA Mid-Atlantic MIRECC Women Veterans Workgroup, and VA Mid-Atlantic MIRECC Workgroup, . "Drug use and childhood-, military- and post-military trauma exposure among women and men veterans." Drug and alcohol dependence 152 (July 2015): 201-208. Full Text
  - Tupler, LA, Hong, JY, Gibori, R, Blitchington, TF, and Krishnan, KRR. "Suicidal ideation and sex differences in relation to 18 major psychiatric disorders in college and university students: anonymous web-based assessment." The Journal of nervous and mental disease 203, no. 4 (April 2015): 269-278. Full Text
  - Gentes, EL, Dennis, PA, Kimbrel, NA, Rissling, MB, Beckham, JC, VA Mid-Atlantic MIRECC Workgroup, , and Calhoun, PS. "DSM-5 posttraumatic stress disorder: factor structure and rates of diagnosis." Journal of Psychiatric Research 59 (December 2014): 60-67. Full Text
  - Kimbrel, NA, Calhoun, PS, Elbogen, EB, Brancu, M, VA Mid-Atlantic MIRECC Registry Workgroup, , and Beckham, JC. "The factor structure of psychiatric comorbidity among Iraq/Afghanistan-era veterans and its relationship to violence, incarceration, suicide attempts, and suicidality." Psychiatry research 220, no. 1-2 (December 2014): 397-403. Full Text
  - Guffanti, G, Ashley-Koch, AE, Roberts, AL, Garrett, ME, Solovieff, N, Ratanatharathorn, A, De Vivo, I, Dennis, M, Ranu, H, Smoller, JW, Liu, Y, Purcell, SM, Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, , Beckham, J, Hauser, MA, and Koenen, KC. "No association between RORA polymorphisms and PTSD in two independent samples." Molecular Psychiatry 19, no. 10 (October 2014): 1056-1057. Full Text
  - Tupler, LA, Weiner, RD, Fernandez, A, Pickett, T, McDonald, SD, McGuire, HH, Hurley, R, Taber, KH, RuthYoash-Gantz, , Miller, M, and SarahIngle, . "The impact of social support on psychological distress for U.S. Afghanistan/Iraq era veterans with PTSD and other psychiatric diagnoses." Psychiatry Research 217, no. 1-2 (June 30, 2014): 86-92. Full Text
  - Olbert, CM, Gala, GJ, and Tupler, LA. "Quantifying heterogeneity attributable to polythetic diagnostic criteria: theoretical framework and empirical application." Journal of abnormal psychology 123, no. 2 (May 2014): 452-462. Full Text
  - Szabo, ST, Kilts, JD, Naylor, JC, Youssef, NA, Strauss, JL, Morey, RA, Brancu, M, Hamer, RM, Bradford, DW, VA Mid-Atlantic MIRECC Work Group, , and Marx, CE. "Amino acids as biomarker candidates for suicidality in male OEF/OIF Veterans: relevance to NMDA receptor modulation and nitric oxide signaling." Military Medicine 179, no. 5 (May 2014): 486-491. Full Text
  - Brown, VM, LaBar, KS, Haswell, CC, Gold, AL, Mid-Atlantic MIRECC Workgroup, , McCarthy, G, and Morey, RA. "Altered resting-state functional connectivity of basolateral and centromedial amygdala complexes in posttraumatic stress disorder." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 39, no. 2 (January 2014): 351-359. Full Text Open Access Copy
  - Kaber, D, Tupler, LA, Clamann, M, Gil, G-H, Zhu, B, Swangnetr, M, Jeon, W, Zhang, Y, Qin, X, Ma, W, and Lee, Y-S. "Evaluation of an augmented virtual reality and haptic control interface for psychomotor training." Assistive technology : the official journal of RESNA 26, no. 1 (January 2014): 51-60. Full Text
  - Kimbrel, NA, Calhoun, PS, Elbogen, EB, Brancu, M, Beckham, JC, Green, KT, Kirby, AC, Dennis, MF, Hoerle, J, Wagner, HR, Runnals, J, Van Voorhees, E, Fairbank, JA, Moore, SD, Weiner, RD, Straits-Troster, K, Tupler, LA, Marx, CE, Morey, RA, Miller-Mumford, M, McDonald, SD, Taber, KH, Yoash-Gantz, RE, and Hurley, RA. "The factor structure of psychiatric comorbidity among Iraq/Afghanistan-era veterans and its relationship to violence, incarceration, suicide attempts, and suicidality." Psychiatry Research 220, no. 1-2 (January 1, 2014): 397-403. Full Text
  - McCormick, CL, Yoash-Gantz, RE, McDonald, SD, Campbell, TC, and Tupler, LA. "Performance on the Green Word Memory Test following Operation Enduring Freedom/Operation Iraqi Freedom-era military service: Test failure is related to evaluation context." Arch Clin Neuropsychol 28, no. 8 (December 2013): 808-823. Full Text Link to Item
  - Taber, KH, Hurley, R, Hayes, JP, Nasser, JD, Seth, S, Beall, SK, Beckham, JC, Tupler, LA, Weiner, R, Fairbank, J, Calhoun, PS, Green, KT, Brancu, M, Hoerle, JM, Pender, M, Strauss, JL, Kudler, H, Eggleston, AM, Guerra, VS, Payne, V, McDonald, SD, Van Voorhees, E, and Davison, R. "Effects of chronic mild traumatic brain injury on white matter integrity in iraq and afghanistan war veterans." Human Brain Mapping 34, no. 11 (November 1, 2013): 2986-2999. Full Text
  - Swinkels, CM, Ulmer, CS, Beckham, JC, Buse, N, and Calhoun, PS. "The Association of Sleep Duration, Mental Health, and Health Risk Behaviors among U.S. Afghanistan/Iraq Era Veterans." Sleep 36, no. 7 (July 1, 2013): 1019-1025. Full Text
  - Perlick, DA, Straits-Troster, K, Strauss, JL, Norell, D, Tupler, LA, Levine, B, Luo, X, Holman, C, Marcus, T, Dixon, LB, and Dyck, DG. "Implementation of multifamily group treatment for veterans with traumatic brain injury." Psychiatric Services (Washington, D.C.) 64, no. 6 (June 2013): 534-540. Full Text
  - Hayes, JP, Morey, RA, and Tupler, LA. "A case of frontal neuropsychological and neuroimaging signs following multiple primary-blast exposure." Neurocase 18, no. 3 (June 2012): 258-269. Full Text Open Access Copy
  - Li, Y, Kaber, DB, Tupler, L, and Lee, Y-S. "Haptic-based Virtual Environment Design and Modeling of Motor Skill Assessment for Brain Injury PatientsRehabilitation." Computer Aided Design and Applications 8, no. 2 (January 2011): 149-162. Full Text
  - Montella, D, Brown, SH, Elkin, PL, Jackson, JC, Rosenbloom, ST, Wahner-Roedler, D, Welsh, G, Cotton, B, Guillamondegui, OD, Lew, H, Taber, KH, Tupler, LA, Vanderploeg, R, and Speroff, T. "Comparison of SNOMED CT versus Medcin terminology concept coverage for mild Traumatic Brain Injury." AMIA Annu Symp Proc 2011 (2011): 969-978. Link to Item
  - Kilts, JD, Tupler, LA, Keefe, FJ, Payne, VM, Hamer, RM, Naylor, JC, Calnaido, RP, Morey, RA, Strauss, JL, Parke, G, Massing, MW, Youssef, NA, Shampine, LJ, tVeterans Affairs Mid-Atlantic Mental Illness, Research, Education and Clinical Center Workgroup, , and Marx, CE. "Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001." Pain Medicine (Malden, Mass.) 11, no. 10 (October 2010): 1469-1476. Full Text
  - Elbogen, EB, Wagner, HR, Fuller, SR, Calhoun, PS, Kinneer, PM, Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, , and Beckham, JC. "Correlates of anger and hostility in Iraq and Afghanistan war veterans." Am J Psychiatry 167, no. 9 (September 2010): 1051-1058. Full Text Link to Item
  - Green, KT, Calhoun, PS, Dennis, MF, Mid-Atlantic Mental Illness Research, Education and Clinical Center Workgroup, , and Beckham, JC. "Exploration of the resilience construct in posttraumatic stress disorder severity and functional correlates in military combat veterans who have served since September 11, 2001." The Journal of Clinical Psychiatry 71, no. 7 (July 2010): 823-830. Full Text
  - Dedert, EA, Green, KT, Calhoun, PS, Yoash-Gantz, R, Taber, KH, Mumford, MM, Tupler, LA, Morey, RA, Marx, CE, Weiner, RD, and Beckham, JC. "Association of trauma exposure with psychiatric morbidity in military veterans who have served since September 11, 2001." Journal of Psychiatric Research 43, no. 9 (June 2009): 830-836. Full Text
  - Belanger, HG, Kretzmer, T, Yoash-Gantz, R, Pickett, T, and Tupler, LA. "Cognitive sequelae of blast-related versus other mechanisms of brain trauma." Journal of the International Neuropsychological Society : Jins 15, no. 1 (January 2009): 1-8. Full Text
  - McDonald, SD, Beckham, JC, Morey, R, Marx, C, Tupler, LA, and Calhoun, PS. "Factorial invariance of posttraumatic stress disorder symptoms across three veteran samples." Journal of Traumatic Stress 21, no. 3 (June 2008): 309-317. Full Text
  - Skotko, BG, Rubin, DC, and Tupler, LA. "H.M.'s personal crossword puzzles: understanding memory and language." Memory (Hove, England) 16, no. 2 (February 2008): 89-96. Full Text Open Access Copy
  - Jackson, GL, Hamilton, NS, and Tupler, LA. "Detecting traumatic brain injury among veterans of Operations Enduring and Iraqi Freedom." N C Med J 69, no. 1 (January 2008): 43-47. (Review) Link to Item
  - Hidalgo, RB, Tupler, LA, and Davidson, JRT. "An effect-size analysis of pharmacologic treatments for generalized anxiety disorder." Journal of Psychopharmacology (Oxford, England) 21, no. 8 (November 2007): 864-872. Full Text
  - Tupler, LA, Krishnan, KRR, Greenberg, DL, Marcovina, SM, Payne, ME, MacFall, JR, Charles, HC, and Doraiswamy, PM. "Predicting memory decline in normal elderly: genetics, MRI, and cognitive reserve." Neurobiology of Aging 28, no. 11 (November 2007): 1644-1656. Full Text
  - Tupler, LA, and De Bellis, MD. "Segmented hippocampal volume in children and adolescents with posttraumatic stress disorder." Biological Psychiatry 59, no. 6 (March 2006): 523-529. Full Text
  - Greenwood, RS, Tupler, LA, Whitt, JK, Buu, A, Dombeck, CB, Harp, AG, Payne, ME, Eastwood, JD, Krishnan, KRR, and MacFall, JR. "Brain morphometry, T2-weighted hyperintensities, and IQ in children with neurofibromatosis type 1." Archives of Neurology 62, no. 12 (December 2005): 1904-1908. Full Text
  - Skotko, BG, Kensinger, EA, Locascio, JJ, Einstein, G, Rubin, DC, Tupler, LA, Krendl, A, and Corkin, S. "Puzzling thoughts for H. M.: can new semantic information be anchored to old semantic memories?." Neuropsychology 18, no. 4 (October 2004): 756-769. Full Text Open Access Copy
  - Vythilingam, M, Charles, HC, Tupler, LA, Blitchington, T, Kelly, L, and Krishnan, KRR. "Focal and lateralized subcortical abnormalities in unipolar major depressive disorder: an automated multivoxel proton magnetic resonance spectroscopy study." Biol Psychiatry 54, no. 7 (October 1, 2003): 744-750. Link to Item
  - Tupler, LA, Krishnan, KRR, McDonald, WM, Dombeck, CB, D'Souza, S, and Steffens, DC. "Anatomic location and laterality of MRI signal hyperintensities in late-life depression." Journal of Psychosomatic Research 53, no. 2 (August 2002): 665-676. Full Text
  - Kim, DM, Xanthakos, SA, Tupler, LA, Barboriak, DP, Charles, HC, MacFall, JR, and Krishnan, KRR. "MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex." Psychiatry Res 114, no. 3 (July 1, 2002): 149-161. Link to Item
  - Steffens, DC, Conway, CR, Dombeck, CB, Wagner, HR, Tupler, LA, and Weiner, RD. "Severity of subcortical gray matter hyperintensity predicts ECT response in geriatric depression." J ECT 17, no. 1 (March 2001): 45-49. Link to Item
  - Madden, DJ, Welsh-Bohmer, KA, and Tupler, LA. "Task Complexity and Signal Detection Analyses of Lexical Decision Performance in Alzheimer's Disease." Developmental Neuropsychology 16, no. 1 (August 1999): 1-18. Full Text
  - Connor, KM, Sutherland, SM, Tupler, LA, Malik, ML, and Davidson, JR. "Fluoxetine in post-traumatic stress disorder. Randomised, double-blind study." The British Journal of Psychiatry : the Journal of Mental Science 175 (July 1999): 17-22. Full Text
  - McDonald, WM, Tupler, LA, Marsteller, FA, Figiel, GS, DiSouza, S, Nemeroff, CB, and Krishnan, KR. "Hyperintense lesions on magnetic resonance images in bipolar disorder." Biological Psychiatry 45, no. 8 (April 1999): 965-971. Full Text
  - Parashos, IA, Tupler, LA, Blitchington, T, and Krishnan, KR. "Magnetic-resonance morphometry in patients with major depression." Psychiatry Research 84, no. 1 (November 1998): 7-15. Full Text
  - Clark, LM, McDonald, WM, Welsh-Bohmer, KA, Siegler, IC, Dawson, DV, Tupler, LA, and Krishnan, KR. "Magnetic resonance imaging correlates of depression in early- and late-onset Alzheimer's disease." Biol Psychiatry 44, no. 7 (October 1, 1998): 592-599. Link to Item
  - Connor, KM, Davidson, JR, Potts, NL, Tupler, LA, Miner, CM, Malik, ML, Book, SW, Colket, JT, and Ferrell, F. "Discontinuation of clonazepam in the treatment of social phobia." J Clin Psychopharmacol 18, no. 5 (October 1998): 373-378. Link to Item
  - Davidson, JR, Tupler, LA, Wilson, WH, and Connor, KM. "A family study of chronic post-traumatic stress disorder following rape trauma." J Psychiatr Res 32, no. 5 (September 1998): 301-309. Full Text Link to Item
  - Steffens, DC, Tupler, LA, Ranga, K, and Krishnan, R. "Magnetic resonance imaging signal hypointensity and iron content of putamen nuclei in elderly depressed patients." Psychiatry Res 83, no. 2 (August 26, 1998): 95-103. Link to Item
  - Lazeyras, F, Charles, HC, Tupler, LA, Erickson, R, Boyko, OB, and Krishnan, KR. "Metabolic brain mapping in Alzheimer's disease using proton magnetic resonance spectroscopy." Psychiatry Research 82, no. 2 (May 1998): 95-106. Full Text
  - Davidson, JR, Weisler, RH, Malik, M, and Tupler, LA. "Fluvoxamine in civilians with posttraumatic stress disorder." J Clin Psychopharmacol 18, no. 1 (February 1998): 93-95. (Letter) Link to Item
  - Passe, TJ, Rajagopalan, P, Tupler, LA, Byrum, CE, MacFall, JR, and Krishnan, KR. "Age and sex effects on brain morphology." Prog Neuropsychopharmacol Biol Psychiatry 21, no. 8 (November 1997): 1231-1237. Link to Item
  - Tupler, LA, Davidson, JR, Smith, RD, Lazeyras, F, Charles, HC, and Krishnan, KR. "A repeat proton magnetic resonance spectroscopy study in social phobia." Biol Psychiatry 42, no. 6 (September 15, 1997): 419-424. Full Text Link to Item
  - Greenwood, RS, Said, SM, Yeh, TL, ElFatatry, MA, Tupler, LA, and Krishnan, KRK. "Changes in brain volume in children with neurofibromatosis 1." ANNALS OF NEUROLOGY 42, no. 3 (September 1997): P4-P4. Link to Item
  - Krishnan, KRR, and Tupler, LA. "Apolipoprotein E-epsilon 4 allele frequency in late-onset depression - Response." BIOLOGICAL PSYCHIATRY 41, no. 8 (April 15, 1997): 912-913. Full Text Link to Item
  - Escalona, R, Tupler, LA, Saur, CD, Krishnan, KR, and Davidson, JR. "Screening for trauma history on an inpatient affective-disorders unit: a pilot study." J Trauma Stress 10, no. 2 (April 1997): 299-305. Link to Item
  - Davidson, JR, Book, SW, Colket, JT, Tupler, LA, Roth, S, David, D, Hertzberg, M, Mellman, T, Beckham, JC, Smith, RD, Davison, RM, Katz, R, and Feldman, ME. "Assessment of a new self-rating scale for post-traumatic stress disorder." Psychological Medicine 27, no. 1 (January 1997): 153-160. Full Text
  - Davidson, JR, Miner, CM, De Veaugh-Geiss, J, Tupler, LA, Colket, JT, and Potts, NL. "The Brief Social Phobia Scale: a psychometric evaluation." Psychological Medicine 27, no. 1 (January 1997): 161-166. Full Text
  - Sutherland, SM, Tupler, LA, Colket, JT, and Davidson, JR. "A 2-year follow-up of social phobia. Status after a brief medication trial." J Nerv Ment Dis 184, no. 12 (December 1996): 731-738. Link to Item
  - Steffens, DC, McDonald, WM, Tupler, LA, Boyko, OB, and Krishnan, KR. "Magnetic resonance imaging changes in putamen nuclei iron content and distribution in normal subjects." Psychiatry Res 68, no. 1 (November 25, 1996): 55-61. Link to Item
  - Said, SM, Yeh, TL, Greenwood, RS, Whitt, JK, Tupler, LA, and Krishnan, KR. "MRI morphometric analysis and neuropsychological function in patients with neurofibromatosis." Neuroreport 7, no. 12 (August 12, 1996): 1941-1944. Link to Item
  - Said, SM, Yeh, TL, ElFatatry, MA, Greenwood, RS, Whitt, JK, Frank, N, Tupler, LA, Ranga, K, and Krishnan, K. "Magnetic resonance imaging morphometric indices as predictive markers for learning disabilities in children with neuofibromatosis-1." ANNALS OF NEUROLOGY 40, no. 2 (August 1996): 149-149. Link to Item
  - Krishnan, KR, Tupler, LA, Ritchie, JC, McDonald, WM, Knight, DL, Nemeroff, CB, and Carroll, BJ. "Apolipoprotein E-epsilon 4 frequency in geriatric depression." Biological Psychiatry 40, no. 1 (July 1996): 69-71. Full Text
  - Charles, HC, Lazeyras, F, Tupler, LA, and Krishnan, KR. "Reproducibility of high spatial resolution proton magnetic resonance spectroscopic imaging in the human brain." Magn Reson Med 35, no. 4 (April 1996): 606-610. Link to Item
  - Tupler, LA, Krishnan, KRR, Ritchie, JC, McDonald, WM, Knight, DL, Nemeroff, CB, and Carroll, BJ. "Cognitive impairment in elderly depressed individuals with APOE epsilon 4." BIOLOGICAL PSYCHIATRY 39, no. 7 (April 1, 1996): 539-539. Link to Item
  - Miner, CM, Davidson, JR, Potts, NL, Tupler, LA, Charles, HC, and Krishnan, KR. "Brain fluoxetine measurements using fluorine magnetic resonance spectroscopy in patients with social phobia." Biol Psychiatry 38, no. 10 (November 15, 1995): 696-698. Full Text Link to Item
  - Tupler, LA, Welsh, KA, Asare-Aboagye, Y, and Dawson, DV. "Reliability of the Rey-Osterrieth Complex Figure in use with memory-impaired patients." Journal of Clinical and Experimental Neuropsychology 17, no. 4 (August 1995): 566-579. Full Text
  - Krishnan, KR, Hays, JC, Tupler, LA, George, LK, and Blazer, DG. "Clinical and phenomenological comparisons of late-onset and early-onset depression." Am J Psychiatry 152, no. 5 (May 1995): 785-788. Full Text Link to Item
  - Tupler, LA, Hege, S, and Ellinwood, EH. "Alcohol pharmacodynamics in young-elderly adults contrasted with young and middle-aged subjects." Psychopharmacology (Berl) 118, no. 4 (April 1995): 460-470. Link to Item
  - Doraiswamy, PM, Tupler, LA, and Krishnan, KR. "Neuroleptic treatment and caudate plasticity." Lancet 345, no. 8951 (March 18, 1995): 734-735. (Letter) Link to Item
  - Krishnan, KR, Tupler, LA, and McDonald, WM. "Background factors and clinical symptoms of major depression with silent cerebral infarction." Stroke 25, no. 12 (December 1994): 2507-null. (Letter) Full Text
  - Rama Krishnan, KR, Ritchie, JC, Tupler, LA, McDonald, WM, Knight, D, Nemeroff, CB, and Marcovina, S. "Apolipoprotein E epsilon 4." Neurology 44, no. 12 (December 1994): 2420-2421. (Letter) Link to Item
  - Sakoda, S, Kuriyama, M, Osame, M, Takahashi, K, Yamano, T, Sasaki, J, and Matsunaga, A. "Apolipoprotein E 4." Neurology 44, no. 12 (December 1, 1994): 2420-2420. Full Text
  - Halpern, SD, Doraiswamy, PM, Tupler, LA, Holland, JM, Ford, SM, and Ellinwood, EH. "Emergency department patterns in psychiatric visits during the holiday season." Ann Emerg Med 24, no. 5 (November 1994): 939-943. Link to Item
  - Davidson, JR, Tupler, LA, and Potts, NL. "Treatment of social phobia with benzodiazepines." J Clin Psychiatry 55 Suppl (June 1994): 28-32. (Review) Link to Item
  - Krishnan, KR, McDonald, WM, and Tupler, LA. "Neuropathology in affective illness." Am J Psychiatry 150, no. 10 (October 1993): 1568-1569. (Letter) Link to Item
  - Davidson, JRT, Potts, N, Krishnan, R, Boyko, O, Charles, C, Smith, R, Ford, S, Tupler, LA, and Wilson, W. "Biology of social phobia." European Neuropsychopharmacology 3, no. 3 (September 1993): 192-193. Full Text
  - Axelson, DA, Doraiswamy, PM, McDonald, WM, Boyko, OB, Tupler, LA, Patterson, LJ, Nemeroff, CB, Ellinwood, EH, and Krishnan, KR. "Hypercortisolemia and hippocampal changes in depression." Psychiatry Res 47, no. 2 (May 1993): 163-173. Link to Item
  - Steffens, DC, Tupler, LA, and Krishnan, KRR. "The neurostructural/neurofunctional basis of depression/mania." Current Opinion in Psychiatry 6, no. 1 (February 1993): 22-26. Full Text
  - Krishnan, KR, McDonald, WM, Doraiswamy, PM, Tupler, LA, Husain, M, Boyko, OB, Figiel, GS, and Ellinwood, EH. "Neuroanatomical substrates of depression in the elderly." Eur Arch Psychiatry Clin Neurosci 243, no. 1 (1993): 41-46. Link to Item
  - Krishnan, KRR, Boyko, OB, McDonald, WM, Charles, HC, Macfall, JR, Tupler, LA, and Upchurch, LW. "Magnetic-resonance morphometry: Image-analysis methodology development for affective disorder." Depression 1, no. 3 (1993): 159-171. Full Text
  - Logue, PE, Tupler, LA, D'Amico, C, and Schmitt, FA. "The Neurobehavioral Cognitive Status Examination: psychometric properties in use with psychiatric inpatients." Journal of Clinical Psychology 49, no. 1 (January 1993): 80-89. Full Text
  - Tupler, LA, Coffey, CE, Logue, PE, Djang, WT, and Fagan, SM. "Neuropsychological importance of subcortical white matter hyperintensity." Arch Neurol 49, no. 12 (December 1992): 1248-1252. (Review) Link to Item
  - Freides, D, Tupler, LA, Hall, JM, and Fowler, TE. "On the independence of physical and nominal codes: a correlational analysis." Brain Cogn 8, no. 3 (December 1988): 409-420. Link to Item
  - STILES, WB, TUPLER, LA, and CARPENTER, JC. "PARTICIPANTS PERCEPTIONS OF SELF-ANALYTIC GROUP SESSIONS." SMALL GROUP BEHAVIOR 13, no. 2 (1982): 237-254. Full Text Link to Item
- Book Sections
  - "Neurosteroids and traumatic brain injury translating biomarkers to therapeutics; overview and pilot investigations in Iraq and Afghanistan era veterans." In Translational Research in Traumatic Brain Injury, 145-161. April 21, 2016.
  - Duffy, VG. "Advances in Human Aspects of Healthcare(Published online)." .: CRC Press,. Full Text
- Conference Papers
  - Nayllor, JC, Payne, VM, Calhoun, PS, Morey, RA, Beckham, JC, Tupler, LA, Duncan, GE, Shampine, LJ, Kilts, JD, and Marx, CE. "L-serine predicts self-reported pain in female OEF/OIF veterans." April 1, 2008. Link to Item
  - Payne, VM, Morey, RA, Hamer, RM, Tupler, LA, Calhoun, PS, Beckham, JC, Shampine, LJ, Naylor, JC, Strauss, JL, Calnaido, RP, Massing, MW, Connor, KM, Davidson, JRT, and Marx, CE. "Neuroactive steroids are related to psychiatric symptoms in veterans returning from iraq and Afghanistan." April 15, 2007. Link to Item
  - Greenwood, RS, McPhail, E, Eastwood, JD, Kealey, SM, MacFall, JR, Tupler, LA, Harp, AG, Buu, A, and Ranga, K. "Focal and diffuse T2-weighted hyperintensities in neurofibromatosis type 1 (NF1)." 2006. Link to Item
Teaching & Mentoring
Recent Courses
- NEUROSCI 494: Research Independent Study 2 2017
- NEUROSCI 496: Research Independent Study 4 2017

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Education, Training, & Certifications

Duke Appointment History

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Book Sections

Conference Papers

Recent Courses