Roger D. Madison

Journal article Ann Neurol · January 2002 Featured Work Regeneration in the peripheral nervous system is often incomplete though it is uncertain which factors, such as the type and extent of the injury or the method or timing of repair, determine the degree of functional recovery. Serial electrophysiological te ... Full text Link to item Cite

Survival of adult rat retinal ganglion cells with regrown axons in peripheral nerve grafts: a comparison of graft attachment with suture of fibrin glue.

Journal article J Neurosurg · August 2000 Featured Work OBJECT: The goal of this study was to examine whether the method of attachment of a peripheral nerve graft would have an effect on retinal ganglion cell (RGC) regeneration. METHODS: The number of adult rat RGCs with regrown axons in a peripheral nerve graf ... Full text Link to item Cite

Netrin-1 and peripheral nerve regeneration in the adult rat.

Journal article Exp Neurol · February 2000 Featured Work Axonal guidance during development of the nervous system is thought to be highly regulated through interactions of axons with attractive, repulsive, and trophic cues. Similar mechanisms regulate axonal regeneration after injury. The netrins have been shown ... Full text Link to item Cite

Factors contributing to preferential motor reinnervation in the primate peripheral nervous system.

Journal article J Neurosci · December 15, 1999 Featured Work Functional recovery after nerve lesions in the peripheral nervous system requires the accurate regeneration of axons to their original target end organs. This paper examines axonal regeneration of the primate median nerve lesioned at the wrist over nerve g ... Full text Link to item Cite

lambda RNA internal standards quantify sensitivity and amplification efficiency of mammalian gene expression profiling.

Journal article Biotechniques · September 1998 Featured Work There is an increasing interest in being able to document simultaneous levels of multiple mRNAs from limited amounts of mammalian tissue. The combination of amplified antisense RNA (aRNA) and reverse Northern blot analysis is one technology that allows the ... Full text Link to item Cite

Monoclonal antibody interaction with the third immunoglobulin-like domain of N-CAM is sufficient to cause cell migration.

Journal article Mol Cell Neurosci · 1997 Featured Work Cellular adhesion molecules can influence a variety of biological mechanisms in the nervous system. These range from the processes of normal development and maintenance to neural plasticity and recovery following injury. The elucidation of the intricate co ... Full text Link to item Cite

Reinnervation accuracy of the rat femoral nerve by motor and sensory neurons.

Journal article J Neurosci · September 15, 1996 Featured Work Previous studies in the rat femoral nerve have shown that regenerating motor neurons preferentially reinnervate a terminal nerve branch to muscle as opposed to skin, a process that has been called preferential motor reinnervation. However, the ability of s ... Full text Link to item Cite

Selective laser-activated lesioning of prelabeled fetal hippocampal grafts by intracellular photolytic chromophore.

Journal article Neuroscience · November 1995 Featured Work Selective removal of grafted tissue is critical to assess the functional role of that tissue in the host, yet is technically difficult for well-dispersed neural grafts. We labeled fetal hippocampal cells with both a nuclear marker (5'-bromodeoxyuridine) an ... Full text Link to item Cite

Monkey median nerve repaired by nerve graft or collagen nerve guide tube.

Journal article J Neurosci · May 1995 Featured Work Nerve regeneration was followed in 15 median and 1 ulnar nerve of eight Macaca fascicularis monkeys by serial electrophysiological assessments over a period of three and a half years. Nerve gaps of 5 mm at the wrist were bridged by collagen-based nerve gui ... Full text Link to item Cite

Point sources of Schwann cells result in growth into a nerve entubulation repair site in the absence of axons: effects of freeze-thawing.

Journal article Exp Neurol · August 1994 Featured Work Axonal regeneration in the peripheral nervous system requires the comigration of Schwann cells along with or ahead of the growing neurites. The present studies were undertaken to elucidate some of the parameters that influence Schwann cell migration into a ... Full text Link to item Cite

Quantitative graft integration of fetal hippocampal transplants labeled with 5' bromodeoxyuridine into normal adult hippocampus.

Journal article Exp Neurol · April 1994 Featured Work Quantitative studies of neural graft development require: (1) a cell label which is both preferential for neurons and can be measured in terms of specific labeling; (2) a serial reconstruction method for identifying labeled cells in a three-dimensional pat ... Full text Link to item Cite