Scholars@Duke
Maragatha Kuchibhatla

Maragatha Kuchibhatla

Professor of Biostatistics & Bioinformatics
Biostatistics & Bioinformatics, Division of Biostatistics
maggie.kuchibhatla@duke.edu
Duke Box 3003, Durham, NC 27710
1508, Blue Zone, Busse Bldg, Trent Drive, DUMC, Durham, NC 27710

Scholarly Works - Journal articles

Predictive Utility of In-Hospital Screening for Postdischarge Depression Symptoms Among Survivors of Critical Illness.

Journal article CHEST Crit Care · September 2026 BACKGROUND: Although postdischarge symptoms of depression are highly prevalent after critical illness, the best timing and strategies for screening are unclear. RESEARCH QUESTION: What is the value of using the 2-item Patient Health Questionnaire (PHQ-2) d ... Full text Link to item Cite

Prospective cohort study identifies barriers and facilitators to point-of-care ultrasound use in an academic emergency department.

Journal article BMJ Open Qual · July 21, 2026 BACKGROUND: Point-of-care ultrasound (POCUS) improves patient care by expedited diagnosis and safer procedures. Despite POCUS benefits, some clinicians, including emergency physicians, do not readily use POCUS. OBJECTIVES: The study objective identified ba ... Full text Link to item Cite

Impact Evaluation of a Clinical Point-of-care Ultrasound Intervention in an Academic Emergency Department.

Journal article West J Emerg Med · June 28, 2026 INTRODUCTION: Point-of-care ultrasound (POCUS) can expedite patient diagnoses and improve procedural safety in emergency department (ED) patients. Nevertheless, clinical POCUS use lags in many ED sites nationwide, with only 40% of community physicians usin ... Full text Link to item Cite

Predictive Factors in Identifying Pediatric Patients at Risk of Diagnostically Limited Videofluoroscopic Swallow Studies.

Journal article Ear Nose Throat J · June 2026 Objective: Videofluoroscopic swallow studies (VFSS) are highly effective in characterizing pediatric dysphagia, but they are time- and resource-intensive, and necessitate the use of radiation. Identifying patients unlikely to benefit from VFSS is crucial t ... Full text Link to item Cite

Postpartum Readmission for Pregnancy-Associated Thrombotic Microangiopathy Is Associated With Poor Maternal Outcomes.

Journal article J Clin Apher · February 2026 The postpartum period represents a high-risk interval for presentation with a pregnancy-associated thrombotic microangiopathy (TMA). Given the possibility of immune thrombotic thrombocytopenic purpura, postpartum TMA is typically treated with initiation of ... Full text Link to item Cite

In patients with suspected thrombotic thrombocytopenic purpura, what is the optimal time to therapeutic plasma exchange?

Journal article Hematol Transfus Cell Ther · 2026 BACKGROUND: In patients with suspected immune thrombotic thrombocytopenic purpura, guidelines suggest that therapeutic plasma exchange should be initiated within eight hours. However, this time threshold may be difficult to attain. This study sought to ide ... Full text Link to item Cite

Comparison of ENLYT®, a Portable Flexible Nasopharyngoscope, with the Standard of Care Nasopharyngoscope.

Journal article Surg Innov · December 2025 ObjectivesThis study seeks to compare a newly developed portable flexible nasopharyngoscope (ENLYT®) to the standard of care (SOC) flexible nasopharyngoscope.MethodsSubjects were consented to undergo a nasopharyngeal scope exam using ENLYT® after SOC nasop ... Full text Link to item Cite

Short-term impact of bariatric surgery on systemic inflammation in patients with asthma.

Journal article Respir Med · December 2025 BACKGROUND: The systemic inflammatory environment in obesity contributes to increased asthma symptoms and diminished asthma control. Asthma patients that have undergone bariatric surgery report significant improvements in asthma symptoms and medication use ... Full text Open Access Link to item Cite

Impact Evaluation After Implementing a Co-Designed Point-Of-Care Ultrasound Program at a Veterans Affairs Emergency Department.

Journal article Australas J Ultrasound Med · November 2025 INTRODUCTION/PURPOSE: Point-of-care ultrasound (POCUS) is an important diagnostic bedside tool, yet a gap remains between Emergency Department (ED) POCUS programme implementation and achieving sustained POCUS use and retention. We performed an impact evalu ... Full text Link to item Cite

Multimodal quality improvement project on reducing hospital perioperative thromboembolic events (Patient Safety Indicator-12).

Journal article BMJ Open Qual · April 3, 2025 BACKGROUND: Venous thromboembolism (VTE), which includes both pulmonary embolism and deep vein thrombosis, is a common yet significant postoperative complication. Patient Safety Indicator (PSI)-12 was introduced by Centers for Medicare & Medicaid Services ... Full text Link to item Cite

Developing A Model to Predict Major Bleeding Among Hospitalized Patients Undergoing Therapeutic Plasma Exchange.

Journal article J Clin Apher · April 2025 Although therapeutic plasma exchange (TPE) can be associated with bleeding, there are currently no known strategies to reliably predict bleeding risk. This study developed a TPE bleeding risk prediction model for hospitalized patients. To develop the predi ... Full text Link to item Cite

Complement activation as a biomarker for platelet-activating antibodies in heparin-induced thrombocytopenia.

Journal article J Thromb Haemost · March 2025 BACKGROUND: Immunoglobulin G antibodies (Abs) to platelet factor 4 (PF4) complexed to heparin (PF4/H) commonly occur after H exposure but cause life-threatening complications of H-induced thrombocytopenia (HIT) in only a few patients. Presently, only plate ... Full text Link to item Cite

Emergency care knowledge, utilization, and barriers in Northern Tanzania: A community-based survey.

Journal article PLOS Glob Public Health · 2025 BACKGROUND: Emergency care systems are critical to improving care for time-sensitive emergency conditions. The growth and development of these systems in Sub-Saharan Africa is becoming a priority. Layperson knowledge and recognition of emergency symptoms a ... Full text Link to item Cite

Venous Thromboembolic Events Following Revisional Gastric Bypass: An Analysis of the MBSAQIP Database from 2015 to 2019 Using Propensity Matching.

Journal article Obes Surg · December 2024 BACKGROUND: Primary bariatric surgery is associated with moderate-to-high risk of venous thromboembolic events (VTE); however, the risk for revisional surgery lacks granularity. Our primary objective was to define the risk of VTE following revisional Roux- ... Full text Link to item Cite

An Adaptive Pragmatic Randomized Controlled Trial of Emergency Department Acupuncture for Acute Musculoskeletal Pain Management.

Journal article Ann Emerg Med · October 2024 STUDY OBJECTIVE: Acute musculoskeletal pain in emergency department (ED) patients is frequently severe and challenging to treat with medications alone. The purpose of this study was to determine the feasibility, acceptability, and effectiveness of adding E ... Full text Link to item Cite

Age-Neutral Surgical Stabilization of Rib Fractures: Breaking the Ageism Barrier.

Journal article J Surg Res · October 2024 INTRODUCTION: Surgical stabilization of rib fractures (SSRF) is associated with lower rates of mortality and fewer complications. This study evaluates whether the decision to undergo SSRF is associated with age, race, ethnicity, and insurance status and as ... Full text Link to item Cite

The Earlier the Better: Surgical Stabilization of Rib Fractures Associated With Improved Outcomes.

Journal article J Surg Res · October 2024 INTRODUCTION: Surgical stabilization of rib fractures (SSRF) has been associated with lower rates of mortality and fewer respiratory complications. This study sought to evaluate the association between SSRF timing and patient outcomes. METHODS: This retros ... Full text Link to item Cite

Bleeding recurrence risk among hospitalized patients undergoing therapeutic plasma exchange: a multi-center study.

Journal article Blood Transfus · September 2024 BACKGROUND: In hospitalized patients undergoing therapeutic plasma exchange (TPE), it is not known how TPE-associated bleeding risk is impacted by a prior bleeding episode. Therefore, to assess the prevalence and predictors of bleeding recurrence, we analy ... Full text Link to item Cite

Predictors of Non-Rhinogenic Facial Pain or Pressure in Otolaryngology Clinic.

Journal article Otolaryngol Head Neck Surg · May 2024 OBJECTIVES: Identify demographic and clinical characteristics that may help differentiate non-rhinogenic facial pain or pressure (NRFP) from sinusitis. STUDY DESIGN: Retrospective single-institution study. SETTING: Tertiary Care Center Rhinology Clinic. ME ... Full text Link to item Cite

Outcomes by time-to-OR for penetrating abdominal trauma patients.

Journal article Am J Emerg Med · May 2024 INTRODUCTION: Time-To-OR is a critical process measure for trauma performance. However, this measure has not consistently demonstrated improvement in outcome. STUDY DESIGN: Using TQIP, we identified facilities by 75th percentile time-to-OR to categorize sl ... Full text Link to item Cite

An epidemiologic study comparing cancer- and noncancer-associated venous thromboembolism in a racially diverse Southeastern United States county.

Journal article Res Pract Thromb Haemost · May 2024 BACKGROUND: Cancer-associated venous thromboembolism (CA-VTE) represents a major cause of morbidity and mortality in patients with cancer. Despite poor outcomes, there is an ongoing knowledge gap in epidemiologic data related to this association. OBJECTIVE ... Full text Link to item Cite

Accuracy and Feasibility of Three-Dimensional Ultrasound Testing in Eye Clinic and Emergency Department Patients with Vision Complaints.

Journal article J Emerg Med · February 2024 BACKGROUND: Ocular emergencies comprise 2-3% of emergency department (ED) visits, with retinal detachment requiring emergency surgery. Two-dimensional ultrasound is a rapid bedside tool but is highly operator dependent. OBJECTIVE: We determined three-dimen ... Full text Link to item Cite

Short-term cardiovascular events after bariatric surgery in patients with metabolic syndrome.

Journal article Surg Obes Relat Dis · January 2024 BACKGROUND: Patients with metabolic syndrome (MetS) are at increased risk of developing cardiovascular disease along with other adverse events after bariatric surgery. OBJECTIVES: The incidence of short-term major adverse cardiovascular events (MACE) in pa ... Full text Open Access Link to item Cite

In hospitalized patients undergoing therapeutic plasma exchange, major bleeding prevalence depends on the bleeding definition: An analysis of The Recipient Epidemiology and Donor Evaluation Study-III.

Journal article J Clin Apher · December 2023 BACKGROUND: Major bleeding in patients undergoing therapeutic plasma exchange (TPE) has been studied in large databases; but without standardizing bleeding definitions. Therefore, we used standardized definitions to evaluate major bleeding in hospitalized ... Full text Link to item Cite

Factors Associated With Triage Decisions in Older Adult Trauma Patients: Impact on Mortality and Morbidity.

Journal article J Surg Res · August 2023 INTRODUCTION: As medical advances have significantly increased the life expectancy among older adults, the number of older patients requiring trauma care has risen proportionately. Nevertheless, it is unclear among this growing population which sociodemogr ... Full text Link to item Cite

In patients with suspected immune TTP, admission source impacts hospital length of stay and time to therapeutic plasma exchange impacts clinical outcomes.

Journal article Thromb Res · July 2023 INTRODUCTION: When immune thrombotic thrombocytopenic purpura (TTP) is suspected, outcomes are impacted by time to therapeutic plasma exchange (TPE). We evaluated the impact of time to TPE on outcomes in suspected TTP cases admitted through the Emergency D ... Full text Link to item Cite

Systematic Review and Meta-analysis for Surgery Versus Stereotactic Radiosurgery for Jugular Paragangliomas.

Journal article Otol Neurotol · March 1, 2023 OBJECTIVE: Comprehensively analyze tumor control and treatment complications for jugular paraganglioma patients undergoing surgery versus stereotactic radiosurgery (SRS). DATABASES REVIEWED: EMBASE, Medline, and Scopus. METHODS: The databases were searched ... Full text Link to item Cite

Belatacept-Based Maintenance Immunosuppression Controls the Post-Transplant Humoral Immune Response in Highly Sensitized Nonhuman Primates.

Journal article Kidney360 · December 29, 2022 Preexisting donor-specific antibodies (DSA) to MHC antigens increase the risk of antibody-mediated rejection (AMR) in sensitized transplant recipients and reduces graft survival. Pretransplant desensitization with costimulation blockade and proteasome inhi ... Full text Link to item Cite

The safety of pediatric use of paracetamol (acetaminophen): a narrative review of direct and indirect evidence.

Journal article Minerva Pediatr (Torino) · December 2022 Paracetamol (acetaminophen) use during pregnancy and early childhood was accepted as safe in the 1970s, but is now a subject of considerable concern. Careful analysis shows that initial acceptance of the drug was based on the false assumption that drug int ... Full text Link to item Cite

Acupuncture for acute musculoskeletal pain management in the emergency department and continuity clinic: a protocol for an adaptive pragmatic randomised controlled trial.

Journal article BMJ Open · September 23, 2022 INTRODUCTION: Chronic musculoskeletal pain causes a significant burden on health and quality of life and may result from inadequate treatment of acute musculoskeletal pain. The emergency department (ED) represents a novel setting in which to test non-pharm ... Full text Link to item Cite

Stress-Delta B-Type Natriuretic Peptide Does Not Exclude ACS in the ED.

Journal article J Appl Lab Med · September 1, 2022 BACKGROUND: There are many detectable changes in circulating biomarkers in the setting of myocardial ischemia. We hypothesize that there are associated changes in circulating B-type natriuretic peptide (BNP) level after stress-induced myocardial ischemia, ... Full text Link to item Cite

Endoscopic Sinus Surgery in Older Patients With Significant Medical Comorbidities.

Journal article Am J Rhinol Allergy · September 2022 BACKGROUND: Endoscopic sinus surgery (ESS) offers excellent outcomes for patients with chronic rhinosinusitis (CRS) in the general population. It is unclear whether older patients with significant medical comorbidities experience similar benefits. OBJECTIV ... Full text Link to item Cite

Evaluation of telephone-assisted cardiopulmonary resuscitation recommendations for out-of-hospital cardiac arrest.

Journal article Resuscitation · September 2022 AIM OF THE STUDY: While out-of-hospital cardiac arrest (OHCA) is associated with poor survival, early bystander CPR (B-CPR) and telephone CPR (T-CPR) improves survival from OHCA. American Heart Association (AHA) Scientific Statements outline recommendation ... Full text Link to item Cite

Central venous catheters are associated with thrombosis among adult inpatients undergoing therapeutic plasma exchange.

Journal article J Clin Apher · August 2022 BACKGROUND: For inpatients undergoing therapeutic plasma exchange (TPE) in the United States, the primary mode of venous access is the central venous catheter (CVC). To evaluate the impact of CVC on thrombosis outcomes of patients undergoing TPE, we analyz ... Full text Open Access Link to item Cite

Racial differences in venous thromboembolism: A surveillance program in Durham County, North Carolina.

Journal article Res Pract Thromb Haemost · July 2022 BACKGROUND: Venous thromboembolism (VTE) affects approximately 1-2 individuals per 1000 annually and is associated with an increased risk for pulmonary hypertension, postthrombotic syndrome, and recurrent VTE. OBJECTIVE: To determine risk factors, incidenc ... Full text Link to item Cite

Trends in risk factors for readmission after bariatric surgery 2015-2018.

Journal article Surg Obes Relat Dis · May 2022 BACKGROUND: Readmission after bariatric surgery is multifactorial. Understanding the trends in risk factors for readmission provides opportunity to optimize patients prior to surgery identify disparities in care, and improve outcomes. OBJECTIVES: This stud ... Full text Link to item Cite

Aptamer-based factor IXa inhibition preserves hemostasis and prevents thrombosis in a piglet model of ECMO.

Journal article Mol Ther Nucleic Acids · March 8, 2022 Extracorporeal membrane oxygenation (ECMO) requires anticoagulation to prevent clotting when the patient's blood contacts the circuit. Unfractionated heparin (UFH) usually prevents clotting but can cause life-threatening bleeding. An anticoagulant that sel ... Full text Link to item Cite

Race Differences in Quality of Life following a Palliative Care Intervention in Patients with Advanced Heart Failure: Insights from the Palliative Care in Heart Failure Trial.

Journal article J Palliat Med · February 2022 Introduction: Black patients have a higher incidence of heart failure (HF) and worse outcomes than white patients. Guidelines recommend palliative care for patients with advanced HF, but no studies have examined outcomes in a black patient cohort. Methods: ... Full text Link to item Cite

Bleeding outcomes of inpatients receiving therapeutic plasma exchange: A propensity-matched analysis of the National Inpatient Sample.

Journal article Transfusion · February 2022 BACKGROUND: Although therapeutic plasma exchange (TPE) is associated with hemostatic abnormalities, its impact on bleeding outcomes is unknown. Therefore, the main study objective was to determine bleeding outcomes of inpatients treated with TPE. STUDY DES ... Full text Open Access Link to item Cite

Impact of Hearing Aid Use on Falls and Falls-Related Injury: Results From the Health and Retirement Study.

Journal article Ear Hear · 2022 OBJECTIVES: Falls are considered a significant public health issue and falls risk increases with age. There are many age-related physiologic changes that occur that increase postural instability and the risk for falls (i.e., age-related sensory declines in ... Full text Open Access Link to item Cite

Impact of dispatcher-assisted cardiopulmonary resuscitation on performance of termination of resuscitation criteria.

Journal article Resuscitation · January 2022 BACKGROUND: Current Advanced Life Support Termination of Resuscitation (TOR) guidelines suggest when to cease cardiopulmonary resuscitation (CPR). With the significant increase of Dispatch-Assisted CPR (DA-CPR) programs, the impact of DA-CPR on the TOR cri ... Full text Link to item Cite

Response to Powell et al., "Do Hearing Aids Prevent Falls? Commentary on Study From the National Health and Nutrition Examination Survey".

Journal article Am J Audiol · December 9, 2021 This letter serves to respond to Powell et al.'s (2021) letter to the editor regarding our recent publication, "Preliminary Evidence on the Impact of Hearing Aid Use on Falls Risk in Individuals With Self-Reported Hearing Loss." In our letter, we respond t ... Full text Link to item Cite

Identifying high-risk surgical patients: A study of older adults whose code status changed to Do-Not-Resuscitate.

Journal article J Am Geriatr Soc · December 2021 BACKGROUND: There is a paucity of data on older adults (age ≥65 years) undergoing surgery who had an inpatient do-not-resuscitate (DNR) order, and the association between timing of DNR order and outcomes. METHODS: This was a retrospective analysis of 1976 ... Full text Link to item Cite

Moving toward patient-centered care in the emergency department: Patient-reported expectations, definitions of success, and importance of improvement in pain-related outcomes.

Journal article Acad Emerg Med · November 2021 OBJECTIVES: Musculoskeletal pain is a common emergency department (ED) presentation, and patient-centered care may improve quality of life, treatment satisfaction, and outcomes. Our objective was to investigate the expectations, definitions of success, and ... Full text Link to item Cite

Ideal high sensitivity troponin baseline cutoff for patients with renal dysfunction.

Journal article Am J Emerg Med · August 2021 OBJECTIVE: High-sensitivity cardiac troponin assays (hs-cTn) aid in diagnosis of myocardial infarction (MI). These assays have lower specificity for non-ST Elevation MI (NSTEMI) in patients with renal disease. Our objective was to determine an optimized cu ... Full text Link to item Cite

Adolescent Bariatric Surgery: Racial Disparities in 30-Day Outcomes Using the MBSAQIP from 2015 to 2018.

Journal article Obes Surg · August 2021 INTRODUCTION: Racial disparities exist in obesity prevalence and obesity-related comorbid conditions among youth. We hypothesized that non-White adolescents would have poorer 30-day outcomes after adolescent bariatric surgery. METHODS: Adolescent patients ... Full text Link to item Cite

Tongue weakness and atrophy differentiates late-onset Pompe disease from other forms of acquired/hereditary myopathy.

Journal article Mol Genet Metab · July 2021 Late-onset Pompe disease (LOPD) is an inherited autosomal recessive progressive metabolic myopathy that presents in the first year of life to adulthood. Clinical presentation is heterogeneous, differential diagnosis is challenging, and diagnostic delay is ... Full text Open Access Link to item Cite

Preliminary Evidence on the Impact of Hearing Aid Use on Falls Risk in Individuals With Self-Reported Hearing Loss.

Journal article Am J Audiol · June 14, 2021 Purpose Falls are considered a significant public health issue, and hearing loss has been shown to be an independent risk factor for falls. The primary objective of this study was to determine if hearing aid use modified (reduced) the association. We hypot ... Full text Link to item Cite

Use of therapeutic plasma exchange in heparin-induced thrombocytopenia: A population-based study.

Journal article J Clin Apher · June 2021 BACKGROUND: Heparin-induced thrombocytopenia (HIT) is characterized by anti-heparin/platelet factor 4 immune complexes, which are removed by therapeutic plasma exchange (TPE). Our main objective was to study TPE outcomes in HIT using a large administrative ... Full text Open Access Link to item Cite

Increasing Naloxone Prescribing in the Emergency Department Through Education and Electronic Medical Record Work-Aids.

Journal article Jt Comm J Qual Patient Saf · June 2021 BACKGROUND: Emergency department (ED) visits for opioid overdose continue to rise. Evidence-based harm reduction strategies for opioid use disorder (OUD), such as providing home naloxone, can save lives, but ED implementation remains challenging. METHODS: ... Full text Link to item Cite

A population-based analysis on the use of therapeutic plasma exchange and intravenous immunoglobulin in heparin-induced thrombocytopenia.

Journal article Thromb Res · May 2021 INTRODUCTION: In heparin-induced thrombocytopenia (HIT), selected patients are treated with therapies directed at the immune response, intravenous immunoglobulin (IVIG) and therapeutic plasma exchange (TPE). To determine IVIG and TPE characteristics and ou ... Full text Open Access Link to item Cite

Increasing Comorbidity and Frailty is Not Associated with Early Postoperative Complications among Men Undergoing Artificial Urinary Sphincter or Sling Implantation: A Real-World Application of NSQIP® Data to Reconstructive Urology.

Journal article Urol Pract · March 2021 INTRODUCTION: Urologists may be hesitant to surgically treat urinary incontinence in comorbid genitourinary cancer survivors. We assessed the relationship between comorbidities and 30-day perioperative outcomes following artificial urinary sphincter and sl ... Full text Link to item Cite

Magnetic Liver Retraction Decreases Postoperative Pain and Length of Stay in Bariatric Surgery Compared to Nathanson Device.

Journal article J Laparoendosc Adv Surg Tech A · February 2021 Objective: Retrospective case-matched comparison of magnetic liver retraction to a bedrail-mounted liver retractor in bariatric surgery specifically targeting short-term postoperative outcomes, including pain and resource utilization. Background: Retractio ... Full text Link to item Cite

Gastroesophageal Reflux Predicts Utilization of Dehydration Treatments After Bariatric Surgery.

Journal article Obes Surg · February 2021 BACKGROUND: Dehydration treatments (DT) provide intravenous fluids to patients in the outpatient setting; however, the utilization of DT is not well-described. We characterize the cohort receiving DT, the first year it was recorded in a bariatric-specific ... Full text Open Access Link to item Cite

Olfactory-Specific Quality of Life Outcomes after Endoscopic Endonasal Surgery of the Sella.

Journal article Allergy Rhinol (Providence) · 2021 OBJECTIVE: To assess olfactory outcomes as measured by an olfactory-specific quality of life (QOL) questionnaire in patients undergoing EESBS for sellar lesions. DESIGN: Retrospective case series. SETTING: Tertiary academic medical center. PARTICIPANTS: In ... Full text Link to item Cite

Respiratory muscle training in late-onset Pompe disease: Results of a sham-controlled clinical trial.

Journal article Neuromuscul Disord · November 2020 To address progressive respiratory muscle weakness in late-onset Pompe disease (LOPD), we developed a 12-week respiratory muscle training (RMT) program. In this exploratory, double-blind, randomized control trial, 22 adults with LOPD were randomized to RMT ... Full text Open Access Link to item Cite

The association between neighborhood socioeconomic status, cardiovascular and cerebrovascular risk factors, and cognitive decline in the Health and Retirement Study (HRS).

Journal article Aging Ment Health · September 2020 Background: A small but growing body of evidence supports a relationship between neighborhood socioeconomic status (NSES) and cognitive decline. Additional work is needed to characterize this relationship controlling for risk factors such as cardiovascular ... Full text Link to item Cite

Racial Disparities in Bariatric Surgery Complications and Mortality Using the MBSAQIP Data Registry.

Journal article Obes Surg · August 2020 BACKGROUND: Racial disparities in postoperative complications have been demonstrated in bariatric surgery, yet the relationship of race to complication severity is unknown. STUDY DESIGN: Adult laparoscopic primary bariatric procedures were queried from the ... Full text Link to item Cite

Cultured thymus tissue implantation promotes donor-specific tolerance to allogeneic heart transplants.

Journal article JCI Insight · June 4, 2020 Eighty-six infants born without a thymus have been treated with allogeneic cultured thymus tissue implantation (CTTI). These infants, who lack T cells and are profoundly immunodeficient at birth, after CTTI from an unmatched donor develop T cells similar t ... Full text Open Access Link to item Cite

Transplant Center Variability in Organ Offer Acceptance and Mortality Among US Patients on the Heart Transplant Waitlist.

Journal article JAMA Cardiol · June 1, 2020 IMPORTANCE: Under the current Centers for Medicare & Medicaid Services guidelines, there is incentivization to optimize posttransplant outcomes regardless of mortality among patients on the waitlist and transplant rates; few data exist with regard to trans ... Full text Link to item Cite

Variability in donor organ offer acceptance and lung transplantation survival.

Journal article J Heart Lung Transplant · April 2020 BACKGROUND: Lung transplantation offers a survival benefit for patients with end-stage lung disease. When suitable donors are identified, centers must accept or decline the offer for a matched candidate on their waitlist. The degree to which variability in ... Full text Link to item Cite

Investigating Predictors of Cognitive Decline Using Machine Learning.

Journal article J Gerontol B Psychol Sci Soc Sci · March 9, 2020 OBJECTIVES: Genetic risks for cognitive decline are not modifiable; however their relative importance compared to modifiable factors is unclear. We used machine learning to evaluate modifiable and genetic risk factors for Alzheimer's disease (AD), to predi ... Full text Link to item Cite

Soft Tissue Anchoring Performance, Biomechanical Properties, and Tissue Reaction of a New Hernia Mesh Engineered to Address Hernia Occurrence and Recurrence.

Journal article J Med Device · December 1, 2019 One opportunity to reduce hernia occurrence and recurrence rates (currently estimated to be 30% at 10 years postoperatively) is by enhancing the ability of hernia meshes to anchor into tissue to prevent mesh migration, mesh contraction, and mesh tearing aw ... Full text Link to item Cite

Heterogeneity in neutrophil responses to immune complexes.

Journal article Blood Adv · October 8, 2019 Immune complexes (ICs) can trigger inflammation and thrombosis, in part, by activating neutrophils. Much attention has focused on the serologic characteristics of ICs and Fc receptors associated with cellular activation, but few studies have examined host ... Full text Link to item Cite

Therapeutic plasma exchange for management of heparin-induced thrombocytopenia: Results of an international practice survey.

Journal article J Clin Apher · October 2019 INTRODUCTION: Anti-heparin/platelet factor 4 antibody immune complexes resulting from heparin-induced thrombocytopenia (HIT) are removed by therapeutic plasma exchange (TPE). We sought to define TPE in HIT practice patterns using an international survey. M ... Full text Open Access Link to item Cite

Symptom Profile of Chronic Rhinosinusitis Versus Obstructive Sleep Apnea in a Tertiary Rhinology Clinic.

Journal article Ann Otol Rhinol Laryngol · October 2019 OBJECTIVES: Patients with undiagnosed obstructive sleep apnea (OSA) often present to an otolaryngologist with symptoms of chronic rhinosinusitis (CRS). This study analyzes symptom profiles of such patients to help identify those who may benefit from polyso ... Full text Link to item Cite

Machine perfusion of donor kidneys may reduce graft rejection.

Journal article Clin Transplant · October 2019 Recent evidence suggests that hypothermic machine perfusion of donor kidneys reduces delayed graft function (DGF). This study addresses the effect of machine perfusion (MP) on allograft rejection in the United States. We assembled a retrospective cohort of ... Full text Link to item Cite

Damage- and pathogen-associated molecular patterns play differential roles in late mortality after critical illness.

Journal article JCI Insight · August 22, 2019 Multiple organ failure (MOF) is the leading cause of late mortality and morbidity in patients who are admitted to intensive care units (ICUs). However, there is an epidemiologic discrepancy in the mechanism of underlying immunologic derangement dependent o ... Full text Open Access Link to item Cite

Factors associated with opioid use after endoscopic sinus surgery.

Journal article Laryngoscope · August 2019 OBJECTIVES/HYPOTHESIS: Responsible prescribing of postoperative pain medications is necessary in combatting the current opioid epidemic in the United States. The goal of this study was to determine which clinical factors affect opioid usage following funct ... Full text Link to item Cite

Analysis of pleiotropic genetic effects on cognitive impairment, systemic inflammation, and plasma lipids in the Health and Retirement Study.

Journal article Neurobiol Aging · August 2019 Variants associated with modulation of c-reactive protein (CRP) and plasma lipids have been investigated for polygenic overlap with Alzheimer's disease risk variants. We examined pleiotropic genetic effects on cognitive impairment conditioned on genetic va ... Full text Link to item Cite

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Journal article Mol Genet Metab · August 2019 INTRODUCTION:: Morbidity and mortality in adults with late-onset Pompe disease (LOPD) results primarily from persistent progressive respiratory muscle weakness despite treatment with enzyme replacement therapy (ERT). To address this need, we have developed ... Full text Open Access Link to item Cite

Sinonasal Quality of Life Outcomes After Extended Endonasal Approaches to the Skull Base.

Journal article J Neurol Surg B Skull Base · August 2019 Introduction  Endoscopic endonasal skull base surgery (EESBS) leads to significant alterations in sinonasal anatomy and physiology. However, there is limited data available on quality of life (QOL) outcomes following EESBS. Methods  A retrospective review ... Full text Link to item Cite

Cervical seatbelt sign is not associated with blunt cerebrovascular injury in children: A review of the national trauma databank.

Journal article Am J Surg · July 2019 BACKGROUND: Blunt cerebrovascular injury (BCVI) is a rare consequence of blunt trauma. There appears to be benefit to an aggressive approach to screening for BCVI due to catastrophic sequelae of unrecognized injury. However, screening for BCVI carries exte ... Full text Link to item Cite

Bleeding After Free Flap-Based Breast Reconstruction: A NSQIP Analysis.

Journal article J Reconstr Microsurg · July 2019 BACKGROUND:  Despite limited oncologic benefit for women without an increased risk for breast cancer, the rates of contralateral prophylactic mastectomy (CPM) have increased. Patients undergoing CPM are more likely to undergo bilateral and immediate breast ... Full text Link to item Cite

Auditory-Perceptual Speech Features in Children With Down Syndrome.

Journal article Am J Intellect Dev Disabil · July 2019 Speech disorders occur commonly in individuals with Down syndrome (DS), although data regarding the auditory-perceptual speech features are limited. This descriptive study assessed 47 perceptual speech features during connected speech samples in 26 childre ... Full text Open Access Link to item Cite

An Assessment of Bleeding Complications Necessitating Blood Transfusion across Inpatient Plastic Surgery Procedures: A Nationwide Analysis Using the National Surgical Quality Improvement Program Database.

Journal article Plast Reconstr Surg · May 2019 BACKGROUND: This study described the prevalence of bleeding complications necessitating blood transfusion across plastic surgery procedures and identified those procedures that may be associated with higher rates of bleeding. METHODS: The authors retrospec ... Full text Link to item Cite

Factors Associated with Revision Surgery after Balloon Sinuplasty.

Journal article Otolaryngol Head Neck Surg · April 2019 OBJECTIVE: Although balloon sinuplasty (BSP) is increasing in popularity, little is known about which patients are the ideal candidates. The objective of this study is to investigate factors that may be associated with BSP failure. STUDY DESIGN: Retrospect ... Full text Link to item Cite

A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling.

Journal article J Endocr Soc · February 1, 2019 Progesterone is primarily a pregnancy-related hormone, produced in substantial quantities after ovulation and during gestation. Traditionally known to function via nuclear receptors for transcriptional regulation, there is also evidence of nonnuclear actio ... Full text Open Access Link to item Cite

Racial Differences in Change in Physical Functioning in Older Male Veterans with HIV.

Journal article AIDS Res Hum Retroviruses · 2019 Little is known about longitudinal change in physical functioning of older African American/Black and White HIV-infected persons. We examined up to 10 years of data on African American (N = 1,157) and White (N = 400) men with HIV infection and comparable H ... Full text Link to item Cite

Polyreactive IgM initiates complement activation by PF4/heparin complexes through the classical pathway.

Journal article Blood · December 6, 2018 The mechanisms by which exposure to heparin initiates antibody responses in many, if not most, recipients are poorly understood. We recently demonstrated that antigenic platelet factor 4 (PF4)/heparin complexes activate complement in plasma and bind to B c ... Full text Link to item Cite

Neighborhoods, sleep quality, and cognitive decline: Does where you live and how well you sleep matter?

Journal article Alzheimers Dement · April 2018 INTRODUCTION: We evaluated the association between neighborhood socioeconomic status (NSES) and sleep quality on cognitive decline in the Health and Retirement Study. METHODS: Health and Retirement Study participants (n = 8090), aged 65+ with DNA and multi ... Full text Link to item Cite

Race as a predictor of postoperative hospital readmission after spine surgery.

Journal article J Clin Neurosci · December 2017 Hospital readmission after surgery results in a substantial economic burden, and several recent studies have investigated the impact of race and ethnicity on hospital readmission rates, with the goal to identify hospitals and patients with high readmission ... Full text Link to item Cite

Improving Postoperative Efficiency: An Algorithm for Expedited Void Trials After Urogynecologic Surgery.

Journal article South Med J · December 2017 OBJECTIVES: To evaluate the relation between voided volume and void trial "success" to create an algorithm that minimizes the need for postvoid residual volume (PVR) assessment in backfill-assisted void trials. METHODS: This article is an ancillary analysi ... Full text Link to item Cite

Evaluation of Hematopoietic Stem Cell Mobilization Rates with Early Plerixafor Administration for Adult Stem Cell Transplantation.

Journal article Biol Blood Marrow Transplant · August 2017 The addition of plerixafor to high-dose colony-stimulating growth factor has been shown to improve stem cell mobilization rates in autologous transplant patients with multiple myeloma and non-Hodgkin lymphoma. This study evaluates the change in administrat ... Full text Link to item Cite

Preventing Episodic Migraine With Caloric Vestibular Stimulation: A Randomized Controlled Trial.

Journal article Headache · July 2017 OBJECTIVE: To evaluate the safety and efficacy of a novel solid-state, caloric vestibular stimulation (CVS) device to provide adjuvant therapy for the prevention of episodic migraine in adult migraineurs. BACKGROUND: Migraine causes significant disability ... Full text Link to item Cite

Meeting Basic Needs: Social Supports and Services Provided by Hospice.

Journal article J Palliat Med · June 2017 OBJECTIVE: Describe social goods and services for which hospices assist patients and families and the resources hospices use to do so. BACKGROUND: Basic social supports and services not routinely covered by insurers may be needed by terminally ill patients ... Full text Link to item Cite

Serologic characterization of anti-protamine/heparin and anti-PF4/heparin antibodies.

Journal article Blood Adv · April 25, 2017 Anti-protamine (PRT)/heparin antibodies are a newly described class of heparin-dependent antibodies occurring in patients exposed to PRT and heparin during cardiac surgery. To understand the biologic significance of anti-PRT/heparin antibodies, we develope ... Full text Link to item Cite

Hospice Access for Undocumented Immigrants.

Journal article JAMA Intern Med · April 1, 2017 Full text Link to item Cite

Cognitive Behavioral Insomnia Therapy for Those With Insomnia and Depression: A Randomized Controlled Clinical Trial.

Journal article Sleep · April 1, 2017 STUDY OBJECTIVE: To compare cognitive behavioral therapy for insomnia (CBT-I) + antidepressant medication (AD) against treatments that target solely depression or solely insomnia. DESIGN: A blinded, randomized split-plot experimental study. SETTING: Two ur ... Full text Link to item Cite

Analgesia and Sedation Requirements in Mechanically Ventilated Trauma Patients With Acute, Preinjury Use of Cocaine and/or Amphetamines.

Journal article Anesth Analg · March 2017 BACKGROUND: The purpose of this study was to determine whether mechanically ventilated trauma patients with a positive urine drug screen (UDS) for cocaine and/or amphetamines have different opioid analgesic and sedative requirements compared with similar p ... Full text Link to item Cite

Dopamine Transporter Imaging has no Impact on Functional Outcomes in de Novo Probable Parkinson's Disease.

Journal article J Parkinsons Dis · 2017 BACKGROUND: Parkinson's disease (PD) is among the most prevalent neurodegenerative conditions. While motor and non-motor aspects of this disease have been well characterized, no objective biomarker exists to support an accurate clinical diagnosis. However, ... Full text Link to item Cite

Positive Impact of Continuous-Flow Left Ventricular Assist Device Implantation on Glycemic Control in Patients with Type 2 Diabetes Mellitus and Advanced Chronic Systolic Heart Failure.

Journal article Pharmacotherapy · December 2016 STUDY OBJECTIVE: To evaluate the impact of continuous-flow left ventricular assist device (LVAD) implantation on glycemic control in patients with type 2 diabetes mellitus and advanced chronic systolic heart failure. DESIGN: Retrospective medical record re ... Full text Link to item Cite

Loss of stiffness in collagen-rich uterine fibroids after digestion with purified collagenase Clostridium histolyticum.

Journal article Am J Obstet Gynecol · November 2016 BACKGROUND: Uterine fibroids are a significant health problem. These common benign tumors occur in 70-80% of women before age 50 years and often cause bleeding and pain and can interfere considerably with daily life. Current treatment options are limited. ... Full text Link to item Cite

315 Race as a Predictor of Postoperative Hospital Readmission After Spine Surgery.

Journal article Neurosurgery · August 2016 INTRODUCTION: Hospital readmission after surgery results in a substantial economic burden, and several recent studies have investigated the impact of race and ethnicity on hospital readmission rates, with the goal to identify hospitals and patients with hi ... Full text Link to item Cite

Vascular considerations in foot and ankle free tissue transfer: Analysis of 231 free flaps.

Journal article Microsurgery · May 2016 OBJECTIVE: Successful foot and ankle soft tissue reconstruction is dependent on a clear understanding of the vascular supply to the foot. The aim of this study was to identify risk factors for reconstructive failure following foot and ankle free tissue tra ... Full text Link to item Cite

Inflammatory Response of Human Gestational Membranes to Ureaplasma parvum Using a Novel Dual-Chamber Tissue Explant System.

Journal article Biol Reprod · May 2016 Preterm premature rupture of membranes (PPROM) is often associated with intra-amniotic inflammation and infection. Current understanding of the pathogenesis of PPROM includes activation of pro-inflammatory cytokines and proteolytic enzymes leading to compr ... Full text Link to item Cite

Are Hospice Admission Practices Associated With Hospice Enrollment for Older African Americans and Whites?

Journal article J Pain Symptom Manage · April 2016 CONTEXT: Hospices that enroll patients receiving expensive palliative therapies may serve more African Americans because of their greater preferences for aggressive end-of-life care. OBJECTIVES: Examine the association between hospices' admission practices ... Full text Link to item Cite

Risk Assessment and Characterization of 30-Day Perioperative Myocardial Infarction Following Spine Surgery: A Retrospective Analysis of 1346 Consecutive Adult Patients.

Journal article Spine (Phila Pa 1976) · March 2016 STUDY DESIGN: A retrospective review. OBJECTIVE: The aim of the study was to perform a risk assessment of 30-day perioperative myocardial infarction (MI) for spine surgery patients. SUMMARY OF BACKGROUND DATA: There is an increased emphasis to reduce compl ... Full text Link to item Cite

Elevated Cardiac Troponin I in Preservation Solution Is Associated With Primary Graft Dysfunction.

Journal article J Card Fail · February 2016 BACKGROUND: Although primary graft dysfunction (PGD) is a leading cause of mortality and morbidity early post-heart transplant, relatively little is known regarding mechanisms involved in PGD development. METHODS AND RESULTS: We examined the relationship b ... Full text Link to item Cite

What are Hospice Providers in the Carolinas Doing to Reach African Americans in Their Service Area?

Journal article J Palliat Med · February 2016 BACKGROUND: Experts and national organizations recommend that hospices work to increase service to African Americans, a group historically underrepresented in hospice. OBJECTIVE: The study objective was to describe strategies among hospices in North and So ... Full text Link to item Cite

Predictors of gastrostomy placement in children with inherited metabolic diseases treated by umbilical cord blood transplantation.

Journal article J Pediatr Surg · July 2015 BACKGROUND/PURPOSE: Children with inherited metabolic diseases (IMDs) undergoing umbilical cord blood transplantation (UCBT) who are at risk for post-transplant failure to thrive may benefit from pretransplant gastrostomy tube (GT) placement. Here we sough ... Full text Link to item Cite

Time to antivenom administration is not associated with total antivenom dose administered in a copperhead-predominant snakebite population.

Journal article Acad Emerg Med · March 2015 OBJECTIVES: To prevent unnecessary antivenom administration in crotaline snakebite, observation for progression is recommended for the patient with minor envenomation whose condition is stable and not progressing. The objective of this study was to determi ... Full text Link to item Cite

Experience with intrawound vancomycin powder for posterior cervical fusion surgery.

Journal article J Neurosurg Spine · January 2015 OBJECT: Recent studies have reported that the local delivery of vancomycin powder is associated with a decrease in spinal surgical site infection. This retrospective cohort study compares posterior cervical fusion cases before and after the routine applica ... Full text Link to item Cite

Effect of APOE and CD33 on Cognitive Decline.

Journal article PLoS One · 2015 OBJECTIVE: An Alzheimer's disease (AD) diagnosis is preceded by a long period of cognitive decline. We previously demonstrated increased risk of decline among individuals possessing one or more APOE ε4 alleles together with a family history of AD. The obje ... Full text Open Access Link to item Cite

Pre-clinical cognitive phenotypes for Alzheimer disease: a latent profile approach.

Journal article Am J Geriatr Psychiatry · November 2014 BACKGROUND: Cognitive profiles for pre-clinical Alzheimer disease (AD) can be used to identify groups of individuals at risk for disease and better characterize pre-clinical disease. Profiles or patterns of performance as pre-clinical phenotypes may be mor ... Full text Link to item Cite

The preventive surgical site infection bundle in colorectal surgery: an effective approach to surgical site infection reduction and health care cost savings.

Journal article JAMA Surg · October 2014 IMPORTANCE: Surgical site infections (SSIs) in colorectal surgery are associated with increased morbidity and health care costs. OBJECTIVE: To determine the effect of a preventive SSI bundle (hereafter bundle) on SSI rates and costs in colorectal surgery. ... Full text Link to item Cite

Preoperative serum albumin level as a predictor of postoperative complication after spine fusion.

Journal article Spine (Phila Pa 1976) · August 15, 2014 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To investigate the association between preoperative baseline serum albumin and postoperative surgical complication. SUMMARY OF BACKGROUND DATA: The prevalence of malnutrition in the hospitalized patient ... Full text Open Access Link to item Cite

Predicting bone scan positivity after biochemical recurrence following radical prostatectomy in both hormone-naive men and patients receiving androgen-deprivation therapy: results from the SEARCH database.

Journal article Prostate Cancer Prostatic Dis · March 2014 BACKGROUND: To evaluate the factors associated with positive bone scans after biochemical recurrence (BCR) following radical prostatectomy in both hormone-naive subjects and subjects after androgen-deprivation therapy (ADT). METHODS: Retrospective analysis ... Full text Link to item Cite

Experience with intrawound vancomycin powder for spinal deformity surgery.

Journal article Spine (Phila Pa 1976) · January 15, 2014 STUDY DESIGN: Retrospective cohort study. OBJECTIVE: To evaluate the ability of local vancomycin powder to prevent deep wound infection after thoracolumbar and lumbar spinal fusion for open deformity cases. SUMMARY OF BACKGROUND DATA: Recent studies report ... Full text Open Access Link to item Cite

Impact of Kidney Function on Effects of the Dietary Approaches to Stop Hypertension (Dash) Diet.

Journal article J Hypertens (Los Angel) · 2014 OBJECTIVES: Although the Dietary Approaches to Stop Hypertension (DASH) diet lowers blood pressure in adults with hypertension, how kidney function impacts this effect is not known. We evaluated whether Estimated Glomerular Filtration Rate (eGFR) modifies ... Full text Open Access Link to item Cite

Race and residence: intercounty variation in black-white differences in hospice use.

Journal article J Pain Symptom Manage · November 2013 CONTEXT: Although blacks use hospice at lower rates than whites in the U.S., racial differences in hospice use vary by geographic area. OBJECTIVES: To describe intercounty variability in black-white differences in hospice use and the association with the s ... Full text Link to item Cite

A comparative analysis of bronchial stricture after lung transplantation in recipients with and without early acute rejection.

Journal article Ann Thorac Surg · September 2013 BACKGROUND: Risk factors and outcomes of bronchial stricture after lung transplantation are not well defined. An association between acute rejection and development of stricture has been suggested in small case series. We evaluated this relationship using ... Full text Link to item Cite

Trajectory classes of body mass index in a representative elderly community sample.

Journal article J Gerontol A Biol Sci Med Sci · June 2013 BACKGROUND: It is unclear whether distinct weight-related trajectory classes, differing in course, demographics, and health characteristics, exist in the elderly population. METHODS: Data came from the 10-year (1986-1996) Duke Established Populations for E ... Full text Link to item Cite

Effect of escitalopram on mental stress-induced myocardial ischemia: results of the REMIT trial.

Journal article JAMA · May 22, 2013 IMPORTANCE: Mental stress can induce myocardial ischemia and also has been implicated in triggering cardiac events. However, pharmacological interventions aimed at reducing mental stress-induced myocardial ischemia (MSIMI) have not been well studied. OBJEC ... Full text Link to item Cite

Association of hospice patients' income and care level with place of death.

Journal article JAMA Intern Med · March 25, 2013 IMPORTANCE: Terminally ill patients with lower incomes are less likely to die at home, even with hospice care. OBJECTIVES: To examine the relationship between income and transfer from home before death and the interaction between income and level of hospic ... Full text Link to item Cite

Thickness of subcutaneous fat as a risk factor for infection in cervical spine fusion surgery.

Journal article J Bone Joint Surg Am · February 20, 2013 BACKGROUND: Surgical site infections increase the incidence of morbidity and mortality as well as health-care expenses. The cost of care increases threefold to fourfold as a consequence of surgical site infection after spinal surgery. The aim of the presen ... Full text Link to item Cite

Prevalence and clinical characteristics of mental stress-induced myocardial ischemia in patients with coronary heart disease.

Journal article J Am Coll Cardiol · February 19, 2013 OBJECTIVES: The goal of this study was to evaluate the prevalence and clinical characteristics of mental stress-induced myocardial ischemia. BACKGROUND: Mental stress-induced myocardial ischemia is prevalent and a risk factor for poor prognosis in patients ... Full text Link to item Cite

A retrospective study of complications of therapeutic plasma exchange in myasthenia.

Journal article Muscle Nerve · February 2013 INTRODUCTION: Venous access for therapeutic plasma exchange (TPE) in myasthenia gravis (MG) can be achieved by central venous catheters (CVC) or peripheral veins (PV), and the preferred method varies among providers. We evaluated our institutional experien ... Full text Link to item Cite

Depressive symptoms and mental stress-induced myocardial ischemia in patients with coronary heart disease.

Journal article Psychosom Med · 2013 OBJECTIVES: The aim of this study was to examine the associations between depressive symptoms and mental stress-induced myocardial ischemia (MSIMI) in patients with coronary heart disease (CHD). METHODS: Adult patients with documented CHD were recruited fo ... Full text Link to item Cite

Health status and depression remission in patients with chronic heart failure: patient-reported outcomes from the SADHART-CHF trial.

Journal article Circ Heart Fail · November 2012 BACKGROUND: Depression is a common comorbidity in heart failure and is strongly associated with increased mortality, morbidity, and reduced health status. Whether depression treatment may result in improvement of health status in heart failure patients wit ... Full text Link to item Cite

Comparison of superior-level facet joint violations during open and percutaneous pedicle screw placement.

Journal article Neurosurgery · November 2012 BACKGROUND: Superior-level facet joint violation by pedicle screws may result in increased stress to the level above the instrumentation and may contribute to adjacent segment disease. Previous studies have evaluated facet joint violations in open or percu ... Full text Open Access Link to item Cite

Response to the clarification of the REMIT trial protocol

Journal article American Heart Journal · November 1, 2012 Full text Cite

Characteristics and outcomes of hospice enrollees with dementia discharged alive.

Journal article J Am Geriatr Soc · September 2012 OBJECTIVES: To examine the characteristics of hospice enrollees with dementia who were discharged alive because their condition stabilized or improved and predictors of death in the year after discharge. DESIGN: Cross-sectional analysis of clinical and adm ... Full text Link to item Cite

A homopolymer polymorphism in the TOMM40 gene contributes to cognitive performance in aging.

Journal article Alzheimers Dement · September 2012 INTRODUCTION: A highly polymorphic T homopolymer was recently found to be associated with late-onset Alzheimer's disease risk and age of onset. OBJECTIVE: To explore the effects of the polymorphic polyT tract (rs10524523, referred as '523') on cognitive pe ... Full text Link to item Cite

Staged total abdominal debranching and thoracic endovascular aortic repair for thoracoabdominal aneurysm.

Journal article J Vasc Surg · September 2012 OBJECTIVE: Thoracoabdominal aortic aneurysms (TAAAs) occur most commonly in elderly individuals, who are often suboptimal candidates for open repair because of significant comorbidities. The availability of a hybrid option, including open visceral debranch ... Full text Link to item Cite

Trajectory classes of depressive symptoms in a community sample of older adults.

Journal article Acta Psychiatr Scand · June 2012 OBJECTIVE: To identify trajectories of depressive symptoms in older community residents. METHOD: Depressive symptomatology, based on a modified Center for Epidemiological Studies-Depression scale, was obtained at years 0, 3, 6, and 10, in the Duke Establis ... Full text Link to item Cite

Plasma omega-3 polyunsaturated fatty acids and survival in patients with chronic heart failure and major depressive disorder.

Journal article J Cardiovasc Transl Res · February 2012 The omega-3 fatty acid (FA) concentration is low in patients with coronary heart disease (CHD). Supplement of omega-3 FA improves cardiovascular outcomes in patients with CHD and heart failure (HF). However, plasma omega-3 FA and its role for prognosis in ... Full text Link to item Cite

Responses of mental stress-induced myocardial ischemia to escitalopram treatment: background, design, and method for the Responses of Mental Stress Induced Myocardial Ischemia to Escitalopram Treatment trial.

Journal article Am Heart J · January 2012 BACKGROUND: Mental stress-induced myocardial ischemia (MSIMI) is common in patients with clinically stable coronary heart disease (CHD) and is associated with poor outcomes. Depression is a risk factor of MSIMI. The REMIT trial investigates whether selecti ... Full text Link to item Cite

Association of depression and survival in patients with chronic heart failure over 12 Years.

Journal article Psychosomatics · 2012 OBJECTIVE: To examine the relationship between depression and survival in patients with chronic heart failure (HF) over a 12-year follow-up period. BACKGROUND: The survival associated with depression has been demonstrated in HF patients for up to 7 years. ... Full text Link to item Cite

Bipolar disorder, brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and brain morphology.

Journal article PLoS One · 2012 In this study of the effect of bipolar status and presence of BDNF Val66Met polymorphism on differences in regional brain volumes, we hypothesized based on previous studies that 1) bipolar subjects will have smaller regional brain volumes than healthy cont ... Full text Link to item Cite

Sexual function after vaginal versus nonvaginal prolapse surgery.

Journal article Female Pelvic Med Reconstr Surg · 2012 OBJECTIVES: To compare sexual function based on the Pelvic Organ Prolapse/Urinary Incontinence Sexual Function Questionnaire (PISQ) in women who underwent vaginal versus nonvaginal surgery for prolapse. METHODS: This was a prospective cohort study of women ... Full text Link to item Cite

Trajectory classes of depression in a randomized depression trial of heart failure patients: a reanalysis of the SADHART-CHF trial.

Journal article Am J Geriatr Pharmacother · December 2011 OBJECTIVE: The objective of this article was to determine whether, in drug intervention trials, growth mixture modeling (GMM) is able to identify drug-responsive trajectory classes that are not evident in traditional growth modeling approaches. METHODS: We ... Full text Link to item Cite

Clinical profiles of primary open angle glaucoma versus normal tension glaucoma patients: a pilot study.

Journal article Curr Eye Res · May 2011 PURPOSE: To study the health profiles and behavioral differences between primary open angle glaucoma (POAG) and normal tension glaucoma (NTG) patients. METHODS: Confidential mail survey of ICD-9 defined POAG (n = 277) and NTG (n = 116) patients was carried ... Full text Link to item Cite

Racial differences in location before hospice enrollment and association with hospice length of stay.

Journal article J Am Geriatr Soc · April 2011 African Americans are less likely than Whites to enroll in hospice. In addition, patients are often referred to hospice very close to death, when they may not have time to take advantage of the full range of hospice services. Understanding how race and loc ... Full text Link to item Cite

Effects of pregabalin on heart rate variability in patients with painful diabetic neuropathy.

Journal article J Clin Psychopharmacol · April 2011 UNLABELLED: Many studies have demonstrated that low heart rate variability (HRV) is a risk for high mortality and morbidity in patients with cardiovascular diseases. The primary purpose of the study was to evaluate whether pregabalin improves HRV in patien ... Full text Link to item Cite

Characteristics of depression remission and its relation with cardiovascular outcome among patients with chronic heart failure (from the SADHART-CHF Study).

Journal article Am J Cardiol · February 15, 2011 Depression is prevalent in patients with heart failure and is associated with a significant increase in hospitalizations and death. Primary results of the Sertraline Against Depression and Heart Disease in Chronic Heart Failure (SADHART-CHF) trial revealed ... Full text Link to item Cite

What the CERAD battery can tell us about executive function as a higher-order cognitive faculty

Journal article Current Gerontology and Geriatrics Research · November 22, 2010 Executive function (EF) is believed to control or influence the integration and application of cognitive functions such as attention and memory and is an important area of research in cognitive aging. Recent studies and reviews have concluded that there is ... Full text Cite

Accuracy of self-reported height and weight in a community-based sample of older African Americans and whites.

Journal article J Gerontol A Biol Sci Med Sci · October 2010 BACKGROUND: To ascertain accuracy of self-reported height, weight (and hence body mass index) in African American and white women and men older than 70 years of age. METHOD: The sample consisted of cognitively intact participants at the third in-person wav ... Full text Link to item Cite

TRAJECTORY CLASSES OF DEPRESSION IN AN OLDER COMMUNITY SAMPLE

Journal article GERONTOLOGIST · October 1, 2010 Link to item Cite

Safety and efficacy of sertraline for depression in patients with heart failure: results of the SADHART-CHF (Sertraline Against Depression and Heart Disease in Chronic Heart Failure) trial.

Journal article J Am Coll Cardiol · August 24, 2010 OBJECTIVES: The objective was to test the hypothesis that heart failure (HF) patients treated with sertraline will have lower depression scores and fewer cardiovascular events compared with placebo. BACKGROUND: Depression is common among HF patients. It is ... Full text Link to item Cite

A prospective study of religion/spirituality and depressive symptoms among adolescent psychiatric patients.

Journal article J Affect Disord · January 2010 OBJECTIVE: Previous research has uncovered relationships between religion/spirituality and depressive disorders. Proposed mechanisms through which religion may impact depression include decreased substance use and enhanced social support. Little investigat ... Full text Link to item Cite

Gray and white matter brain volumes in older adults with bipolar disorder.

Journal article Int J Geriatr Psychiatry · December 2009 OBJECTIVES: Structural magnetic resonance imaging (MRI) studies have been inconsistent in demonstrating volumetric differences in subjects with bipolar disorder. Most studies have not found difference in total gray or white matter in bipolar patients compa ... Full text Link to item Cite

Racial differences in self-reported exposure to information about hospice care.

Journal article J Palliat Med · October 2009 BACKGROUND: Previous research suggests that lack of knowledge of hospice is a barrier to the use of hospice care by African Americans. However, there is little data examining racial differences in exposure to hospice information. OBJECTIVES: Examine racial ... Full text Link to item Cite

Relationships between circulating metabolic intermediates and insulin action in overweight to obese, inactive men and women.

Journal article Diabetes Care · September 2009 OBJECTIVE: To determine whether circulating metabolic intermediates are related to insulin resistance and beta-cell dysfunction in individuals at risk for type 2 diabetes. RESEARCH DESIGN AND METHODS: In 73 sedentary, overweight to obese, dyslipidemic indi ... Full text Link to item Cite

Development and pilot testing of computerized order entry algorithms for geriatric problems in nursing homes.

Journal article J Am Geriatr Soc · September 2009 OBJECTIVES: To develop order entry algorithms for five common nursing home problems and to test their acceptance, use, and preliminary effect on nine quality indicators and resource utilization. DESIGN: Pre-post, quasi-experimental study. SETTING: Two Depa ... Full text Link to item Cite

Marital Status and Prognosis of Patients with Heart Failure

Journal article Journal of Cardiac Failure · August 2009 Full text Cite

Racial Differences in Self-Reported Exposure to Hospice Information

Journal article JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · March 1, 2009 Link to item Cite

Differential gene expression of interleukin-1 receptor associated kinase-1 and interleukin-1 receptor associated kinase-M in peripheral blood mononuclear cells of young and aged rats following preconditioning with endotoxin.

Journal article Shock · January 2009 The IL-1 receptor-associated kinase 1 (IRAK-1) and IRAK-M are key signaling molecules in cellular responses to endotoxin initiated through the Toll-like receptors (TLRs). The aim of this study was to evaluate the effect of age on the modulation of TLRs and ... Full text Link to item Cite

Hyperintense MRI lesions in bipolar disorder: A meta-analysis and review.

Journal article Int Rev Psychiatry · 2009 BACKGROUND: Cortical and subcortical hyperintensities in magnetic resonance imaging (MRI) scans are thought to represent areas of ischemic damage to brain tissue. Researchers have focused on the possible role these lesions may have in psychiatric disorders ... Full text Link to item Cite

Stressful life events in older bipolar patients.

Journal article Int J Geriatr Psychiatry · December 2008 OBJECTIVE: Theories about the impact of stressful life events (SLE) in bipolar disorder have focused on their role early in the disease. Few studies have examined SLE in older bipolar patients. We wanted to assess the impact of SLE in late life bipolar dis ... Full text Link to item Cite

Antidepressant use, depression, and survival in patients with heart failure.

Journal article Arch Intern Med · November 10, 2008 BACKGROUND: Recent studies suggest that the use of antidepressants may be associated with increased mortality in patients with cardiac disease. Because depression has also been shown to be associated with increased mortality in these patients, it remains u ... Full text Link to item Cite

What explains racial differences in the use of advance directives and attitudes toward hospice care?

Journal article J Am Geriatr Soc · October 2008 Cultural beliefs and values are thought to account for differences between African Americans and whites in the use of advance directives and beliefs about hospice care, but few data clarify which beliefs and values explain these differences. Two hundred fi ... Full text Link to item Cite

Frontal white matter anisotropy and antidepressant remission in late-life depression.

Journal article PLoS One · September 24, 2008 INTRODUCTION: Neuroanatomic features associated with antidepressant treatment outcomes in older depressed individuals are not well established. This study used diffusion tensor imaging to examine frontal white matter structure in depressed subjects undergo ... Full text Link to item Cite

Safety and efficacy of sertraline for depression in patients with CHF (SADHART-CHF): a randomized, double-blind, placebo-controlled trial of sertraline for major depression with congestive heart failure.

Journal article Am Heart J · September 2008 BACKGROUND: Sertraline, a selective serotonin-reuptake inhibitor, has demonstrated substantial mood improvement in patients with post myocardial infarction or with unstable angina. The impact of sertraline on the prognosis and depression of patients with c ... Full text Link to item Cite

Specialized palliative care services are associated with improved short- and long-term caregiver outcomes.

Journal article Support Care Cancer · June 2008 GOALS OF WORK: The goal of this study was to evaluate, at a population level, the association between specialized palliative care services (SPCS) and short- and long-term caregiver outcomes. PATIENTS AND METHODS: The Health Omnibus Survey, a face-to-face s ... Full text Link to item Cite

Frontal Gray Matter Changes in Late Life Bipolar Disorder

Journal article AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY · March 1, 2008 Link to item Cite

Identifying trajectories of depressive symptoms for women caring for their husbands with dementia.

Journal article J Am Geriatr Soc · February 2008 OBJECTIVES: To use an innovative statistical method, Latent Class Trajectory Analysis (LCTA), to identify and describe subgroups (called trajectories) of caregiver depressive symptoms in a national sample of wives providing informal care for their husbands ... Full text Link to item Cite

Racial differences in hospice revocation to pursue aggressive care.

Journal article Arch Intern Med · January 28, 2008 BACKGROUND: Hospice provides supportive care to terminally ill patients at the end of life. However, some enrollees leave hospice before death in search of therapies that may prolong survival. Because of a greater preference for life-sustaining therapies a ... Full text Link to item Cite

The effect of spousal caregiving and bereavement on depressive symptoms.

Journal article Aging Ment Health · January 2008 The objective of the study was to determine whether spousal caregiving and bereavement increases caregiver depressive symptoms. We followed 1,967 community-dwelling elderly couples from the 1993 Health and Retirement Study (HRS) until 2002 (five bi-annual ... Full text Link to item Cite

Trajectories of caregiving time provided by wives to their husbands with dementia.

Journal article Alzheimer Dis Assoc Disord · 2008 Spouses are often the first providers of informal care when their partners develop dementia. We used The National Longitudinal Caregiver Study (NLCS, 4 annual surveys, 1999 to 2002) and identified 3 distinct longitudinal patterns (trajectory classes) of to ... Full text Link to item Cite

Geographical segregation and IL-6: a marker of chronic inflammation in older adults.

Journal article Biomark Med · 2008 AIM: To examine environmental sociodemographic risks of high IL-6, a marker of chronic inflammation in older adults. METHODS: We spatially linked 1990 USA Census tract demographic and economic measures to a prospective cohort study of representative commun ... Full text Link to item Cite

Racial differences in the growth of noncancer diagnoses among hospice enrollees.

Journal article J Pain Symptom Manage · September 2007 Patients with noncancer life-limiting illnesses now represent over half of all hospice enrollees, compared to only one-quarter of enrollees in 1992. Whether this growth in enrollees with noncancer diagnoses has been similar for Caucasians and African Ameri ... Full text Link to item Cite

Relationship between depressive symptoms and long-term mortality in patients with heart failure.

Journal article Am Heart J · July 2007 BACKGROUND: Depression is prevalent in patients with heart failure (HF) and is associated with short-term poor prognosis. However, the long-term effect of depression and the use of self-administered depression evaluation on HF prognosis remained unknown. T ... Full text Link to item Cite

Comparison of performance on the CERAD neuropsychological battery of hispanic patients and cognitively normal controls at two sites

Journal article Clinical Gerontologist · April 12, 2007 Based on 88 non-demented controls and 140 AD patients enrolled at the University of Southern California, and 102 Spanish-speaking dementia patients at the University of Pennsylvania, we developed norms, stratified by disease severity, for the Spanish-langu ... Full text Cite

Effect of cancer screening and desirable health behaviors on functional status, self-rated health, health service use and mortality.

Journal article J Am Geriatr Soc · January 2007 OBJECTIVES: To determine whether some health behaviors of older people (e.g., obtaining cancer screens) have a limited and others (e.g., exercise) have a broad association with population-level health status 4 to 6 years later. DESIGN: Longitudinal cohort. ... Full text Link to item Cite

Congregational health ministries: a national study of pastors' views.

Journal article Public Health Nurs · 2007 OBJECTIVES: Since the 1980s, there has been a growing, but little studied, movement that organizes church-based health services under the direction of a coordinator, usually a registered nurse. These Congregational Health Ministries (CHMs) emphasize health ... Full text Link to item Cite

Identifying frailty in hospitalized older adults with significant coronary artery disease.

Journal article J Am Geriatr Soc · November 2006 OBJECTIVES: To characterize physiological variation in hospitalized older adults with severe coronary artery disease (CAD) and evaluate the prevalence of frailty in this sample, to determine whether single-item performance measures are good indicators of m ... Full text Link to item Cite

Racial differences in next-of-kin participation in an ongoing survey of satisfaction with end-of-life care: a study of a study.

Journal article J Palliat Med · October 2006 Despite disparities in health care access and quality, African Americans are underrepresented in many areas of clinical investigation, including research in end-of-life care. Because of the importance of surrogate reports in assessing the quality of end-of ... Full text Link to item Cite

Cerebellar volumes in pediatric maltreatment-related posttraumatic stress disorder.

Journal article Biol Psychiatry · October 1, 2006 BACKGROUND: The results of previous studies suggest structural brain differences in pediatric maltreatment-related posttraumatic stress disorder (PTSD) However, posterior fossa volumes were not examined, despite the consensus that the cerebellum is importa ... Full text Link to item Cite

The impact of health status on physicians' intentions to offer cancer screening to older women.

Journal article J Gerontol A Biol Sci Med Sci · August 2006 BACKGROUND: Screening for breast and cervical cancer reduces disease-specific mortality, but high rates of comorbidity and disability among elderly persons may alter the risks and benefits of screening. METHODS: We performed a mail survey of primary care p ... Full text Link to item Cite

The predictive value of self-report scales compared with physician diagnosis of depression in hemodialysis patients.

Journal article Kidney Int · May 2006 The prevalence of depression in end-stage renal disease (ESRD) patients on hemodialysis has not been definitively determined. We examined the prevalence of depression and the sensitivity, specificity, positive, and negative likelihood ratios (+LR and -LR) ... Full text Link to item Cite

Impact of anemia on mortality, cognition, and function in community-dwelling elderly.

Journal article Am J Med · April 2006 PURPOSE: To explore the impact of varying hemoglobin levels on mortality, function, and cognition in a representative population of older persons. METHODS: Participants in this prospective cohort study included 1 744 men and women, aged 71 years or older, ... Full text Link to item Cite

Caregivers' reasons for nursing home placement: clues for improving discussions with families prior to the transition.

Journal article Gerontologist · February 2006 Featured Work PURPOSE: This study identifies the relative importance of reasons for institutionalization endorsed by caregivers of patients with dementia; examines the relationship between caregivers' reasons for institutionalization and indicators of caregiver and pati ... Full text Link to item Cite

Cortical white matter microstructural abnormalities in bipolar disorder.

Journal article Neuropsychopharmacology · December 2005 This article reports on preliminary findings describing microstructural abnormalities in the white matter of cortical areas thought to be associated with bipolar disorder. In all, 14 patients with bipolar disorder and 21 nonpsychiatrically ill control subj ... Full text Link to item Cite

Dementia and Alzheimer's disease in community-dwelling elders taking vitamin C and/or vitamin E.

Journal article Ann Pharmacother · December 2005 BACKGROUND: Since increased oxidative stress may impair cognition and be a risk factor for dementia, there has been interest in determining whether use of antioxidants could protect against such events. OBJECTIVE: To determine whether supplement use of vit ... Full text Link to item Cite

Modeling association in longitudinal binary outcomes: a brief review.

Journal article Aging Ment Health · May 2005 Featured Work In order to better understand aging, longitudinal studies are run in which participants are evaluated repeatedly and selected end-points (e.g., score on a cognitive screen, falls, occurrence/reoccurrence of a condition) are examined. The objective of the p ... Full text Link to item Cite

Performance on the CERAD neuropsychology battery of two samples of Japanese-American elders: norms for persons with and without dementia.

Journal article J Int Neuropsychol Soc · March 2005 Norms for cognitive measures used to assess dementia are scant for minority groups, in particular for older Japanese Americans. Using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neuropsychology Battery, we compared the baseline p ... Full text Link to item Cite

Medical comorbidity in a bipolar outpatient clinical population.

Journal article Neuropsychopharmacology · February 2005 The presence of medical illnesses among inpatients with bipolar disorder is known to complicate treatment and lengthen hospital stay. However, except for a few specific diseases, little is known about prevalence of medical illnesses in bipolar outpatients ... Full text Link to item Cite

Prognostic value of anxiety and depression in patients with chronic heart failure.

Journal article Circulation · November 30, 2004 Featured Work BACKGROUND: Anxiety is often present with depression and may be one of its manifestations. Although the adverse effects of depression in patients with chronic heart failure (CHF) have been well studied, the relation between anxiety and CHF prognosis has no ... Full text Link to item Cite

The association between depression and chronic kidney disease and mortality among patients hospitalized with congestive heart failure.

Journal article Am J Kidney Dis · August 2004 BACKGROUND: The point prevalence of depression and its relationship to poor outcomes among patients with chronic kidney disease (CKD) has not been fully characterized. METHODS: We performed a secondary analysis of a prospective cohort of 374 patients admit ... Full text Link to item Cite

Caudate volume measurement in older adults with bipolar disorder.

Journal article Int J Geriatr Psychiatry · February 2004 BACKGROUND: Decreased caudate volumes have been noted in unipolar depressed subjects, especially in the elderly and those with cognitive impairment. No differences have been noted in initial studies of multi-aged bipolar subjects; however, this region has ... Full text Link to item Cite

Hippocampal volume measurement in older adults with bipolar disorder.

Journal article Am J Geriatr Psychiatry · 2004 OBJECTIVE: Decreased hippocampal volumes have been noted in unipolar depressed subjects, especially in elderly patients and those with cognitive impairment. Initial studies of mixed-aged bipolar subjects and controls have had conflicting findings, with mos ... Full text Link to item Cite

A 6-month observational study of the relationship between weight loss and behavioral symptoms in institutionalized Alzheimer's disease subjects.

Journal article J Am Med Dir Assoc · 2004 OBJECTIVE: Weight loss is a common occurrence in Alzheimer's disease (AD). This study was undertaken to investigate the relationship between weight loss and behavioral symptoms in institutionalized AD subjects. DESIGN: Observational study. SETTING: Two fac ... Full text Link to item Cite

The contribution of hip fracture to risk of subsequent fractures: data from two longitudinal studies.

Journal article Osteoporos Int · November 2003 Featured Work BACKGROUND: The contribution of hip fracture to the risk of subsequent fractures is unclear. METHODS: Data from the Baltimore Hip Studies and the Established Populations for Epidemiologic Studies of the Elderly (EPESE) were used. Baltimore subjects enrolle ... Full text Link to item Cite

Comparison of methods for analyzing longitudinal binary outcomes: cognitive status as an example.

Journal article Aging Ment Health · November 2003 Featured Work Longitudinal data generate correlated observations. Ignoring correlation can lead to incorrect estimation of standard errors, resulting in incorrect inferences of parameters. In the example used here, standard logistic regression, a population-averaged (PA ... Full text Link to item Cite

Analyzing ordered longitudinal outcomes of self-rated health

Journal article GERONTOLOGIST · October 1, 2003 Link to item Cite

Alternative statistical approaches to identifying dementia in a community-dwelling sample.

Journal article Aging Ment Health · September 2003 Featured Work Little attention has been paid to examining the extent to which alternative statistical models may facilitate identification of persons with dementia. Using a sub-sample of the Duke Established Populations for Epidemiologic Studies of the Elderly, two anal ... Full text Link to item Cite

Laxative use in the community-dwelling elderly.

Journal article Am J Geriatr Pharmacother · September 2003 BACKGROUND: Constipation, a common and sometimes severe problem in the elderly, is often treated with laxatives. OBJECTIVE: The purpose of this study was to determine the prevalence of laxative use and identify determinants of such use among representative ... Full text Link to item Cite

Social support in elderly patients with bipolar disorder.

Journal article Bipolar Disord · February 2003 OBJECTIVE: The role of social support in bipolar disorder is poorly understood. It is known that young and middle-aged patients with impaired social support are more likely to be treatment resistant and have increased hospitalization. However, the role of ... Full text Link to item Cite

From supervised to unsupervised exercise: Factors associated with exercise adherence

Journal article Journal of Aging and Physical Activity · January 1, 2003 Getting older adults to initiate and maintain long-term exercise is an important public health mandate. This study is an analysis of a clinical trial of 112 sedentary adults, age 65-90 years, randomly assigned to 1 of 2 exercise interventions. We examined ... Full text Cite

Assessing risk factors for mortality in elderly White and African American people: implications of alternative analyses.

Journal article Gerontologist · December 2002 Featured Work PURPOSE: The aim of this study was to ascertain whether the determinants of death differ as a function of type of analysis in a representative sample of older African American and White people with comparable mortality rates. DESIGN AND METHODS: Participan ... Full text Link to item Cite

Gait initiation in community-dwelling adults with Parkinson disease: comparison with older and younger adults without the disease.

Journal article Phys Ther · June 2002 BACKGROUND AND PURPOSE: Initiation of gait requires transitions from relatively stationary positions to stability with movement and from double- to single-limb stances. These are deliberately destabilizing activities that may be difficult for people with e ... Link to item Cite

Effects of antidepressant medication on mortality in patients with congestive heart failure

Journal article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · March 6, 2002 Link to item Cite

Impact of inappropriate drug use on mortality and functional status in representative community dwelling elders.

Journal article Med Care · February 2002 Featured Work BACKGROUND: The predictive validity of Drug Utilization Review (DUR) and drugs-to-avoid criteria in elders is unknown. OBJECTIVES: To evaluate the relationship between use of inappropriate drugs as determined by these explicit criteria and mortality and de ... Full text Link to item Cite

Application of the continuous scale physical functional performance test to people with parkinson disease

Journal article Neurology Report · January 1, 2002 Parkinson disease PD is a chronic progressive neurological disorder, often resulting in substantial limitation of function. A number of self-report and performance-based measures have been used to quantify change of disease state or function in people who ... Full text Cite

Psychometric evaluation of 2 comprehensive condition-specific quality of life instruments for women with pelvic floor disorders.

Journal article Am J Obstet Gynecol · December 2001 OBJECTIVE: To evaluate the psychometric properties of the Pelvic Floor Distress Inventory (PFDI) and the Pelvic Floor Impact Questionnaire (PFIQ). METHODS: The PFDI and PFIQ are based on the structure and content of two previously validated questionnaires ... Full text Link to item Cite

Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure.

Journal article Arch Intern Med · August 13, 2001 Featured Work BACKGROUND: Patients with congestive heart failure (CHF) may have a high prevalence of depression, which may increase the risk of adverse outcomes. OBJECTIVE: To determine the prevalence and relationship of depression to outcomes of patients hospitalized w ... Full text Link to item Cite

Spinal movement and performance of a standing reach task in participants with and without Parkinson disease.

Journal article Phys Ther · August 2001 BACKGROUND AND PURPOSE: Evidence suggests that individuals with early and mid-stage Parkinson disease (PD) have diminished range of motion (ROM). Spinal ROM influences the ability to function. In this investigation, the authors examined available spinal RO ... Full text Link to item Cite

Women's interest in chemoprevention for breast cancer.

Journal article Arch Intern Med · July 9, 2001 BACKGROUND: Chemoprevention is the use of pharmacologic or natural agents to inhibit the development of cancer. Tamoxifen citrate is the only approved chemopreventive agent for breast cancer. We sought to determine whether women are interested in taking a ... Full text Link to item Cite

Inappropriate drug prescribing, mortality and functional status decline in community dwelling elders.

Journal article JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · April 1, 2001 Link to item Cite

Depressive symptoms, menopausal status, and climacteric symptoms in women at midlife.

Journal article Psychosom Med · 2001 OBJECTIVE: Previous studies have found increased rates of depression in women aged 45 to 54 years, but the factors that influence these rates are not understood. It was assessed whether higher rates of depressive symptoms were associated with menopausal st ... Full text Link to item Cite

Relationships among breast cancer perceived absolute risk, comparative risk, and worries.

Journal article Cancer Epidemiol Biomarkers Prev · September 2000 When trying to predict breast cancer screening, it may be important to understand the relationships between perceived breast cancer risks and worries about getting breast cancer. This study examines the extent to which women's worries about breast cancer c ... Link to item Cite

Spinal flexibility and balance control among community-dwelling adults with and without Parkinson's disease.

Journal article J Gerontol A Biol Sci Med Sci · August 2000 BACKGROUND: One area of research that requires further elaboration is the relationship between impairments and functional limitations. By identifying specific contributors to functional limitations, it may be possible to establish intervention strategies, ... Full text Link to item Cite

Inappropriate drug use among community-dwelling elderly.

Journal article Pharmacotherapy · May 2000 This study examined inappropriate drug use defined by updated criteria among respondents in the second and third in-person waves of the Duke Established Populations for Epidemiologic Studies of the Elderly. Information about sociodemographics, health statu ... Full text Link to item Cite

An application of generalizability theory to study a physical performance measure in Parkinson's disease.

Journal article Aging (Milano) · February 2000 Featured Work Clinicians and researchers frequently quantify impairments and functional ability to monitor patient's symptoms and progress. For some patients, such as those with Parkinson's disease (PD), symptoms can fluctuate from day to day, making reliable measuremen ... Full text Link to item Cite

Depression in heart failure: Clinical characteristics and impact on outcomes

Journal article JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY · February 1, 2000 Link to item Cite

The relationship of social support, social networks and negative events with depression in patients with coronary artery disease

Journal article Aging and Mental Health · January 1, 2000 This study examined the relationship of social relationships and negative life events with major depression among 335 inpatients with coronary artery disease (CAD) who were free of neurological illnesses. Depression was assessed using the Duke Depression E ... Full text Cite

Kinematic characterization of standing reach: comparison of younger vs. older subjects.

Journal article Clin Biomech (Bristol) · May 1999 OBJECTIVE: To characterize typical spinal motions that occur during standing reach and to describe differences in spinal motions and center of pressure displacements during reach between younger and older healthy adults. DESIGN: Exploratory, cross sectiona ... Full text Link to item Cite

Reliability of physical performance tests in four different randomized clinical trials.

Journal article Arch Phys Med Rehabil · May 1999 OBJECTIVES: (1) To assess the test-retest reliability of physical performance tests in subject groups with different levels of impairment and disability, and (2) to assess the stability of these tests over different time intervals. DESIGN: Test-retest, rep ... Full text Link to item Cite

Quality of life and Parkinson's disease.

Journal article J Gerontol A Biol Sci Med Sci · April 1999 BACKGROUND: People with Parkinson's disease (PD) have a progressive loss of function eventually leading to severe disability. Although PD would be expected to have a profound impact on an individual's psychosocial health, there is relatively limited resear ... Full text Link to item Cite

The effect of major depression on functional status in patients with coronary artery disease.

Journal article J Am Geriatr Soc · March 1999 OBJECTIVE: To examine the effect of major depression on reported functional status in a group of patients with coronary artery disease (CAD). SETTING: An inpatient cardiology service. PARTICIPANTS: Three hundred thirty-five inpatients with coronary artery ... Full text Link to item Cite

Depressive symptoms and nine-year survival of 1,001 male veterans hospitalized with medical illness.

Journal article Am J Geriatr Psychiatry · 1999 Featured Work Authors examined effects of depressive symptoms on after-discharge survival of hospitalized medically ill male veterans. Psychosocial and physical health evaluations were performed on a consecutive sample of 1,001 patients ages 20-39 (16%) and 65-102 years ... Link to item Cite

Use of health services by medically ill depressed elderly patients after hospital discharge.

Journal article Am J Geriatr Psychiatry · 1999 Featured Work The authors evaluated a consecutive sample of 542 elderly hospital patients for depression; of these, 160 depressed and 171 nondepressed patients were followed up for a median of 47 weeks after discharge. A subset of 113 depressed patients had significant ... Link to item Cite

Exercise to improve spinal flexibility and function for people with Parkinson's disease: a randomized, controlled trial.

Journal article J Am Geriatr Soc · October 1998 Featured Work OBJECTIVES: The effectiveness of an exercise intervention for people in early and midstage Parkinson's disease (stages 2 and 3 of Hoehn and Yahr) in improving spinal flexibility and physical performance in a sample of community-dwelling older people is des ... Full text Link to item Cite

Inappropriate medication use among community dwelling elderly residents.

Journal article JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · September 1, 1998 Link to item Cite

Inappropriate medication use among community dwelling elderly residents.

Journal article JOURNAL OF THE AMERICAN GERIATRICS SOCIETY · September 1998 Link to item Cite

Use of health services by hospitalized medically ill depressed elderly patients.

Journal article Am J Psychiatry · July 1998 OBJECTIVE: The authors examined whether depression is associated with greater use of health services by elderly medical patients before and during hospitalization. METHOD: Depression and recent use of health services were assessed in 542 patients aged 60 o ... Full text Link to item Cite

Religion and the survival of 1010 hospitalized veterans

Journal article Journal of Religion and Health · January 1, 1998 Objective: To examine the effects of religious affiliation and religious coping on survival of acutely-hospitalized medically-ill male veterans following discharge. Sample and Methods: Between 1987 and 1989, comprehensive psychosocial and physical-health e ... Full text Cite

Factors that disturb sleep in nursing home residents.

Journal article Aging (Milano) · June 1997 The purpose of this cross-sectional survey was to examine subjective sleep quality, and identify factors that disturb sleep in cognitively intact nursing home (NH) residents. We interviewed 51 cognitively intact NH residents using a validated instrument, t ... Full text Link to item Cite

Measures of shoulder protraction and thoracolumbar rotation.

Journal article J Orthop Sports Phys Ther · May 1997 Physical therapists need objective measures that can be used reliably with a variety of subject groups to document upper quadrant function. Two aspects of upper quadrant motion, shoulder protraction and thoracolumbar rotation, are assessed routinely in cli ... Full text Link to item Cite

Reliability of impairment and physical performance measures for persons with Parkinson's disease.

Journal article Phys Ther · January 1997 BACKGROUND AND PURPOSE: Parkinson's disease (PD) is characterized by rigidity, postural instability, bradykinesia, and tremor, as well as other musculoskeletal impairments and functional limitations. The purpose of this investigation was to determine the r ... Full text Link to item Cite

The reliability, validity, and stability of a measure of physical activity in the elderly.

Journal article Arch Phys Med Rehabil · August 1996 OBJECTIVE: To assess the reliability, validity, and stability of an accelerometer-based monitor of physical activity in an elderly population. DESIGN: Six studies were conducted to assess the Tritrac, a newly available accelerometer capable of storing thre ... Full text Link to item Cite

Relationships between mobility of axial structures and physical performance.

Journal article Phys Ther · March 1996 BACKGROUND AND PURPOSE: Many day-to-day activities require bending and twisting motions of the spine (axial mobility). Because little is known about the relationship between axial mobility and physical performance, this investigation explored these relatio ... Full text Link to item Cite

Smoothing-based lack-of-fit tests: Variations on a theme

Journal article Journal of Nonparametric Statistics · January 1, 1996 In recent years a number of authors have studied lack-of-fit tests that make use of nonparametric smoothing ideas. Some of these tests, such as those proposed by Eubank and Hart (1992), utilize data-driven smoothing parameters as test statistics. In this p ... Full text Cite