Scholars@Duke
Mai ElMallah

Mai ElMallah

Professor of Pediatrics
Pediatrics, Pulmonary and Sleep Medicine
mai.elmallah@duke.edu
2301 Erwin Road, Durham, NC 27710

Scholarly Works - Conferences

Using Order Sets to Increase Pediatric Pulmonary Follow-up After Asthma Exacerbation Emergency Department Visit

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractRATIONALE: Most patients who present to the emergency department (ED) for asthma exacerbations have poorly controlled asthma that temporarily improves but continues to be uncontrolled. Effective a ... Full text Cite

Gene Therapy for Respiratory Pathology in Duchenne Muscular Dystrophy

Conference American Journal of Respiratory and Critical Care Medicine · May 1, 2025 AbstractIntroduction: Duchenne muscular dystrophy (DMD) is an X-linked severe neuromuscular disorder, caused by a lack of dystrophin which results in progressive muscular degeneration. As the disease prog ... Full text Cite

PPMO treatment improves respiratory function in the mdx mouse model of Duchenne Muscular Dystrophy

Conference Physiology · May 2025 Duchenne muscular dystrophy (DMD) is an X-linked recessive disorder caused by dystrophin deficiency. Respiratory complications due to progressive muscle weakness are a major cause of morbidity and mortality in DMD. Exon skipping therapy, mediated ... Full text Cite

Molecular modulation in Pompe disease following acute intermittent hypoxia

Conference Physiology · May 2025 Pompe disease results in cardiorespiratory distress secondary to glycogen accumulation in the lysosomes of all muscle types and motor neurons. The only approved treatment is enzyme replacement therap ... Full text Cite

Respiratory pathology in the mdx/utrn-/- mouse: A murine model for Duchenne Muscular Dystrophy (DMD)

Conference Plos One · February 1, 2025 Duchenne muscular dystrophy (DMD) is an X-linked devastating disease caused by a lack of dystrophin which results in progressive muscle weakness. As muscle weakness progresses, respiratory insufficiency and hypoventilation result in significant morbidity a ... Full text Cite

Alveolar Cell Pathology in Pompe Disease

Conference B54. EARLY ORIGINS OF PEDIATRIC LUNG DISEASE · May 2023 Full text Cite

Respiratory Dysfunction in TDP-43 A315T Mice-Mouse Model of Amyotrophic Lateral Sclerosis

Conference C109. EVEN BETTER THAN THE REAL THING: ADVANCED MODELS OF LUNG DISEASE · May 2023 Full text Cite

A Large Lung Abscess: A Foreign Body or an Unusual Bronchoscopy Complication?

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · May 1, 2023 Link to item Cite

Pompe mice have improved respiration during hypercapnic challenge following acute intermittent hypoxia

Conference Physiology · May 2023 Pompe disease results in cardiorespiratory distress secondary to glycogen accumulation in the lysosomes of all muscle types and motor neurons. The only approved treatment is enzyme replacement therapy (ERT), which improves survival, however, it ca ... Full text Cite

Accumulation of pathological Ataxin-7 in the medulla leads to hypoglossal (XII) motor unit pathology

Conference FASEB journal : official publication of the Federation of American Societies for Experimental Biology · May 1, 2022 SCA7 is an autosomal dominant neurological disorder caused by a deleterious CAG repeat expansion in the coding region of the ataxin-7 gene on chromosome 3. Patients with infantile SCA-7 have the largest repeat expansion characterized by progressive loss of ... Full text Cite

Respiratory Pathology in a Humanized Mouse Model of Duchenne Muscular Dystrophy

Conference The FASEB Journal · May 2021 Duchenne muscular dystrophy (DMD) is the most common X‐linked disease affecting 1 in 3500 male births. DMD is characterized by mutations in the DMD gene, which ... Full text Cite

Phrenic and Hypoglossal motor unit pathology in a Spinocerebellar ataxia type 7 mouse model

Conference The FASEB Journal · May 2021 Spinocerebellar ataxia type 7 (SCA7) is an autosomal dominant neurodegenerative disorder caused by a deleterious CAG repeat expansion in the coding region of the ataxin‐7 ... Full text Cite

Glycogen accumulation in smooth muscle in the Pompe disease mouse

Conference Molecular Genetics and Metabolism · February 2021 Full text Cite

Respiratory Dysfunction in a Mouse Model of Spinocerebellar Ataxia 7

Conference The FASEB Journal · April 2020 Spinocerebellar ataxia type 7 (SCA‐7) is a neurodegenerative polyglutamine disease within the family of spinocerebellar ataxias. Classically SCA7 is a disease o ... Full text Cite

Motor Neuron Pathology Leads to Respiratory Deficiency in Optn −/− Mice

Conference The FASEB Journal · April 2020 Amyotrophic Lateral Sclerosis (ALS) is a devastating and fatal neurodegenerative disease with no current cure. Respiratory failure is the leading cause of death in ALS. Death occurs3–5 years after diagnosis when patients with ALS ultimately succumb ... Full text Cite

Respiratory Directed Gene Therapy Prolongs Survival In An Als Mouse Model

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2018 Link to item Cite

Respiratory And Airway Smooth Muscle Pathology In A Pompe Disease Mouse Model

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2017 Link to item Cite

Characterization Of Pulmonary Mechanics Of The Sod1g93a Als Mouse Model

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Exercise Induced Respiratory Insufficiency In A Murine Model Of Very Long-Chain Acyl-Coa Dehydrogenase Deficiency

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2016 Link to item Cite

Ampakines Enhance Respiratory Motor Output In A Murine Model Of Pompe Disease

Conference AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE · January 1, 2014 Link to item Cite

Amblyopia: Is visual loss permanent.

Conference INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE · March 15, 2000 Link to item Cite