Manal F. Abdelmalek | Scholars@Duke

Manal F. Abdelmalek
Professor of Medicine

My research interests include metabolic liver disease, particularly obesity-related liver disease and its association with complications of the insulin resistance syndrome. I am interested in studying the clinical, environmental, and genetic risk factors for nonalcoholic fatty liver disease, new therapeutic options for treatment, and evaluating the impact of NAFLD from a public health perspective.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Gastroenterology, Medicine 2017

Contact Information

03119 Hosp South, Suite 03107, Room 03125, Durham, NC 27710
Duke Box 3913, Durham, NC 27710
manal.abdelmalek@duke.edu (919) 684-3262

Background
Education, Training, & Certifications
- Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences 1995 - 1998
- Medical Resident, Medicine, Mayo School of Health Sciences 1992 - 1995
- M.D., University Missouri Kansas City 1992
Duke Appointment History
- Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2014 - 2017
- Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2006 - 2014
- Instructor, Temporary in the Department of Medicine, Medicine, Gastroenterology, Medicine 2006
Research
Selected Grants
- Gilead 384-1943 awarded by Gilead Sciences, Inc. 2017 - 2025
- Gilead 384-1944 awarded by Gilead Sciences, Inc. 2017 - 2025
- Duke CTSA (KL2) awarded by National Institutes of Health 2018 - 2023
- Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
- Target-NASH awarded by TARGET PharmaSolutions, Inc. 2017 - 2023
- Intercept 747-303 awarded by Intercept Pharmaceuticals, Inc 2015 - 2022
- FALCON 1 awarded by Bristol-Myers Squibb Company 2018 - 2022
- FALCON 2 awarded by Bristol-Myers Squibb Company 2018 - 2022
- Genfit GFT505-315-1 NASH awarded by GENFIT 2016 - 2022
- Novartis LJC242A2201J awarded by Novartis Pharmaceuticals Corporation 2018 - 2021
- Duke Training Grant in Digestive Diseases and Nutrition awarded by National Institutes of Health 1988 - 2021
- Intercept 747-304 awarded by Intercept Pharmaceuticals, Inc 2017 - 2021
- Galectin GI-026 awarded by Galectin Therapeutics, Inc. 2015 - 2021
- Enanta EDP 305-101 awarded by Enanta Pharmaceuticals, Inc. 2018 - 2020
- Madrigal MGL-3196-05 awarded by Madrigal Pharmaceuticals, Inc. 2016 - 2020
- Gilead 454-4378 awarded by Gilead Sciences, Inc. 2018 - 2020
- Allergan 301-002 awarded by Allergan, Inc. 2017 - 2019
- Allergan 201-002 awarded by Allergan, Inc. 2017 - 2019
- Conatus IDN-6556-12 awarded by Conatus Pharmaceuticals 2015 - 2019
- Progenity PRO-121-NAFLD awarded by Progenity, Inc. 2017 - 2019
- Conatus IDN 6556-14 awarded by Conatus Pharmaceuticals 2016 - 2019
- Genetic and Epigenetic Markers of Progressive Nonalcoholic Fatty Liver Disease awarded by American Association for the Study of Liver Diseases 2018 - 2019
- Conatus IDN 6556-17 awarded by Conatus Pharmaceuticals 2017 - 2019
- Shire SHP626-201 awarded by Shire Human Genetics Therapies 2016 - 2019
- GILEAD 426-3989 awarded by Gilead Sciences, Inc. 2016 - 2019
- TOBIRA 652-2-203 awarded by Tobira Therapeutics, Inc 2014 - 2019
- NASH Clinical Research Network awarded by National Institutes of Health 2004 - 2019
- Intercept 747-117 awarded by Intercept Pharmaceuticals, Inc 2018 - 2019
- BMS MB130-045 awarded by Bristol-Myers Squibb Company 2015 - 2019
- NGM 15-0105 awarded by NGM Biopharmaceuticals 2015 - 2019
- Boehringer BI 1467335 awarded by Boehringer Ingelheim Pharmaceuticals, Inc. 2017 - 2019
- ARREST - GALMED awarded by Galmed Pharmaceuticals Ltd. 2015 - 2019
- Gilead 384-1497 awarded by Gilead Sciences, Inc. 2015 - 2019
- Intercept 747-209 awarded by Intercept Pharmaceuticals, Inc 2015 - 2019
- Gilead 402-1852 awarded by Gilead Sciences, Inc. 2016 - 2019
- Cirius EMMINENCE awarded by Cirius Therapeutics 2017 - 2018
- Exalenz - CSPH-EX-0414 awarded by Exalenz Bioscience Ltd. 2016 - 2018
- Immuron IMM-124E awarded by Immuron, Ltd 2014 - 2018
- Glympse Bio NASH awarded by Glympse Bio, Inc. 2017
- Acoustic Radiation Force Based Hepatic Elasticity Quantification and Imaging awarded by National Institutes of Health 2001 - 2017
- ARI-3037MO-006 awarded by Arisaph Pharmaceuticals, Inc. 2015 - 2017
- Impact of Fructose on Metabolism, Energy Homeostasis and MR biomarkers in NAFLD awarded by National Institutes of Health 2012 - 2016
- Synageva BioPharma LAL-CSS01 awarded by Synageva BioPharma 2014 - 2016
- Development and clinical validation of a clinical diagnostic/prognostic laboratory test for liver disease awarded by Metabolon, Inc. 2014 - 2016
- Characterizing Alcohol's Effects on Repair of Liver Injury awarded by National Institutes of Health 2009 - 2012
- Hyperinsulimia and Insulin Resistance in Nonalcoholic Fatty Liver Disease awarded by National Institutes of Health 2006 - 2010
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Younossi, Z, Stepanova, M, Sanyal, AJ, Harrison, SA, Ratziu, V, Abdelmalek, MF, Diehl, AM, Caldwell, S, Shiffman, ML, Schall, RA, McColgan, B, Subramanian, GM, Myers, RP, Muir, A, Afdhal, NH, Bosch, J, and Goodman, Z. "The conundrum of cryptogenic cirrhosis: Adverse outcomes without treatment options." Journal of Hepatology 69, no. 6 (December 2018): 1365-1370. Full Text
  - Loomba, R, Jain, A, Diehl, AM, Guy, CD, Portenier, D, Sudan, R, Singh, S, Faulkner, C, Richards, L, Hester, KD, Okada, L, Li, X-J, Mimms, L, and Abdelmalek, MF. "Validation of Serum Test for Advanced Liver Fibrosis in Patients with Nonalcoholic Steatohepatitis." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association (November 15, 2018). Full Text
  - Glass, O, Henao, R, Patel, K, Guy, CD, Gruss, HJ, Syn, W-K, Moylan, CA, Streilein, R, Hall, R, Mae Diehl, A, and Abdelmalek, MF. "Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease." Hepatology Communications 2, no. 11 (November 2018): 1344-1355. Full Text
  - Wildman-Tobriner, B, Middleton, MM, Moylan, CA, Rossi, S, Flores, O, Chang, ZA, Abdelmalek, MF, Sirlin, CB, and Bashir, MR. "Association Between Magnetic Resonance Imaging-Proton Density Fat Fraction and Liver Histology Features in Patients With Nonalcoholic Fatty Liver Disease or Nonalcoholic Steatohepatitis." Gastroenterology 155, no. 5 (November 2018): 1428-1435.e2. Full Text
  - Jayakumar, S, Middleton, MS, Lawitz, EJ, Mantry, PS, Caldwell, SH, Arnold, H, Mae Diehl, A, Ghalib, R, Elkhashab, M, Abdelmalek, MF, Kowdley, KV, Stephen Djedjos, C, Xu, R, Han, L, Mani Subramanian, G, Myers, RP, Goodman, ZD, Afdhal, NH, Charlton, MR, Sirlin, CB, and Loomba, R. "Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonsertib." Journal of Hepatology (October 4, 2018). Full Text
  - Harrison, SA, Abdelmalek, MF, Caldwell, S, Shiffman, ML, Diehl, AM, Ghalib, R, Lawitz, EJ, Rockey, DC, Schall, RA, Jia, C, McColgan, BJ, McHutchison, JG, Subramanian, GM, Myers, RP, Younossi, Z, Ratziu, V, Muir, AJ, Afdhal, NH, Goodman, Z, Bosch, J, Sanyal, AJ, and GS-US-321-0105 and GS-US-321-0106 Investigators, . "Simtuzumab Is Ineffective for Patients With Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis." Gastroenterology 155, no. 4 (October 2018): 1140-1153. Full Text
  - Moylan, CA, and Abdelmalek, MF. "Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis." Hepatology (Baltimore, Md.) 68, no. 4 (October 2018): 1646-1648. Full Text
  - Yang, JD, Abdelmalek, MF, Guy, CD, Diehl, AM, and Suzuki, A. "Reply." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 16, no. 10 (October 2018): 1684-null. (Letter) Full Text
  - Yang, JD, Abdelmalek, MF, Guy, CD, Diehl, AM, and Suzuki, A. "Reply." Clinical Gastroenterology and Hepatology 16, no. 10 (October 1, 2018): 1684-null. (Letter) Full Text Open Access Copy
  - Chalasani, N, Abdelmalek, MF, Loomba, R, Kowdley, KV, McCullough, AJ, Dasarathy, S, Neuschwander-Tetri, BA, Terrault, N, Ferguson, B, Shringarpure, R, Shapiro, D, and Sanyal, AJ. "Relationship Between Three Commonly Used Non-invasive Fibrosis Biomarkers and Improvement in Fibrosis Stage in Patients With NASH." Liver International : Official Journal of the International Association for the Study of the Liver (September 25, 2018). Full Text
  - Loomba, R, Sanyal, AJ, Kowdley, KV, Terrault, N, Chalasani, NP, Abdelmalek, MF, McCullough, AJ, Shringarpure, R, Ferguson, B, Lee, L, Chen, J, Liberman, A, Shapiro, D, and Neuschwander-Tetri, BA. "Factors Associated With Histologic Response in Adult Patients With Nonalcoholic Steatohepatitis." Gastroenterology (September 15, 2018). Full Text
  - Kleinstein, SE, Rein, M, Abdelmalek, MF, Guy, CD, Goldstein, DB, Mae Diehl, A, and Moylan, CA. "Whole-Exome Sequencing Study of Extreme Phenotypes of NAFLD." Hepatology Communications 2, no. 9 (September 5, 2018): 1021-1029. Full Text
  - Younossi, ZM, Loomba, R, Anstee, QM, Rinella, ME, Bugianesi, E, Marchesini, G, Neuschwander-Tetri, BA, Serfaty, L, Negro, F, Caldwell, SH, Ratziu, V, Corey, KE, Friedman, SL, Abdelmalek, MF, Harrison, SA, Sanyal, AJ, Lavine, JE, Mathurin, P, Charlton, MR, Goodman, ZD, Chalasani, NP, Kowdley, KV, George, J, and Lindor, K. "Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis." Hepatology (Baltimore, Md.) 68, no. 1 (July 2018): 349-360. (Review) Full Text
  - Younossi, ZM, Loomba, R, Rinella, ME, Bugianesi, E, Marchesini, G, Neuschwander-Tetri, BA, Serfaty, L, Negro, F, Caldwell, SH, Ratziu, V, Corey, KE, Friedman, SL, Abdelmalek, MF, Harrison, SA, Sanyal, AJ, Lavine, JE, Mathurin, P, Charlton, MR, Chalasani, NP, Anstee, QM, Kowdley, KV, George, J, Goodman, ZD, and Lindor, K. "Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis." Hepatology (Baltimore, Md.) 68, no. 1 (July 2018): 361-371. (Review) Full Text
  - Friedman, SL, Ratziu, V, Harrison, SA, Abdelmalek, MF, Aithal, GP, Caballeria, J, Francque, S, Farrell, G, Kowdley, KV, Craxi, A, Simon, K, Fischer, L, Melchor-Khan, L, Vest, J, Wiens, BL, Vig, P, Seyedkazemi, S, Goodman, Z, Wong, VW-S, Loomba, R, Tacke, F, Sanyal, A, and Lefebvre, E. "A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis." Hepatology (Baltimore, Md.) 67, no. 5 (May 2018): 1754-1767. Full Text
  - Jensen, T, Abdelmalek, MF, Sullivan, S, Nadeau, KJ, Green, M, Roncal, C, Nakagawa, T, Kuwabara, M, Sato, Y, Kang, D-H, Tolan, DR, Sanchez-Lozada, LG, Rosen, HR, Lanaspa, MA, Diehl, AM, and Johnson, RJ. "Fructose and sugar: A major mediator of non-alcoholic fatty liver disease." Journal of Hepatology 68, no. 5 (May 2018): 1063-1075. (Review) Full Text
  - Siddiqui, MS, Harrison, SA, Abdelmalek, MF, Anstee, QM, Bedossa, P, Castera, L, Dimick-Santos, L, Friedman, SL, Greene, K, Kleiner, DE, Megnien, S, Neuschwander-Tetri, BA, Ratziu, V, Schabel, E, Miller, V, Sanyal, AJ, and Liver Forum Case Definitions Working Group, . "Case definitions for inclusion and analysis of endpoints in clinical trials for nonalcoholic steatohepatitis through the lens of regulatory science." Hepatology (Baltimore, Md.) 67, no. 5 (May 2018): 2001-2012. Full Text
  - Harrison, SA, Rinella, ME, Abdelmalek, MF, Trotter, JF, Paredes, AH, Arnold, HL, Kugelmas, M, Bashir, MR, Jaros, MJ, Ling, L, Rossi, SJ, DePaoli, AM, and Loomba, R. "NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial." Lancet (London, England) 391, no. 10126 (March 5, 2018): 1174-1185. Full Text
  - Vuppalanchi, R, Siddiqui, MS, Van Natta, ML, Hallinan, E, Brandman, D, Kowdley, K, Neuschwander-Tetri, BA, Loomba, R, Dasarathy, S, Abdelmalek, M, Doo, E, Tonascia, JA, Kleiner, DE, Sanyal, AJ, Chalasani, N, and NASH Clinical Research Network, . "Performance characteristics of vibration-controlled transient elastography for evaluation of nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 67, no. 1 (January 2018): 134-144. Full Text
  - Wegermann, K, Henao, R, Diehl, AM, Murphy, SK, Abdelmalek, MF, and Moylan, CA. "Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study." Plos One 13, no. 9 (January 2018): e0204308-null. Full Text
  - Newton, KP, Feldman, HS, Chambers, CD, Wilson, L, Behling, C, Clark, JM, Molleston, JP, Chalasani, N, Sanyal, AJ, Fishbein, MH, Lavine, JE, Schwimmer, JB, and Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN), . "Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children." The Journal of Pediatrics 187 (August 2017): 141-146.e1. Full Text
  - Kappus, M, and Abdelmalek, M. "De Novo and Recurrence of Nonalcoholic Steatohepatitis After Liver Transplantation." Clinics in liver disease 21, no. 2 (May 2017): 321-335. (Review) Full Text
  - Patel, YA, Henao, R, Moylan, CA, Guy, CD, Piercy, DL, Diehl, AM, and Abdelmalek, MF. "Reply to Kim et al." The American Journal of Gastroenterology 112, no. 5 (May 2017): 807-808. Full Text
  - Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Lavine, JE, Yates, K, Klair, J, Terrault, NA, Clark, JM, Unalp-Arida, A, Diehl, AM, Suzuki, A, and Nonalcoholic Steatohepatitis Clinical Research Network, . "Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 15, no. 1 (January 2017): 127-131.e2. Full Text
  - Abdelmalek, MF. "NAFLD: The clinical and economic burden of NAFLD: time to turn the tide." Nature Reviews. Gastroenterology & Hepatology 13, no. 12 (December 2016): 685-686. Full Text
  - Nelson, JE, Handa, P, Aouizerat, B, Wilson, L, Vemulakonda, LA, Yeh, MM, Kowdley, KV, and NASH Clinical Research Network, . "Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms." Alimentary Pharmacology & Therapeutics 44, no. 11-12 (December 2016): 1253-1264. Full Text
  - Patel, YA, Henao, R, Moylan, CA, Guy, CD, Piercy, DL, Diehl, AM, and Abdelmalek, MF. "Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis." The American Journal of Gastroenterology 111, no. 11 (November 2016): 1591-1598. Full Text
  - Klair, JS, Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Yates, K, Unalp-Arida, A, Lavine, JE, Clark, JM, Diehl, AM, Suzuki, A, and Nonalcoholic Steatohepatitis Clinical Research Network, . "A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 64, no. 1 (July 2016): 85-91. Full Text
  - Ratziu, V, Harrison, SA, Francque, S, Bedossa, P, Lehert, P, Serfaty, L, Romero-Gomez, M, Boursier, J, Abdelmalek, M, Caldwell, S, Drenth, J, Anstee, QM, Hum, D, Hanf, R, Roudot, A, Megnien, S, Staels, B, Sanyal, A, and GOLDEN-505 Investigator Study Group, . "Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening." Gastroenterology 150, no. 5 (May 2016): 1147-1159.e5. Full Text
  - Thrasher, T, and Abdelmalek, MF. "Nonalcoholic Fatty Liver Disease." North Carolina medical journal 77, no. 3 (May 2016): 216-219. Full Text
  - Zhu, R, Baker, SS, Moylan, CA, Abdelmalek, MF, Guy, CD, Zamboni, F, Wu, D, Lin, W, Liu, W, Baker, RD, Govindarajan, S, Cao, Z, Farci, P, Diehl, AM, and Zhu, L. "Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers." The Journal of Pathology 238, no. 4 (March 2016): 531-542. Full Text
  - Abdelmalek, MF, and Day, C. "Sugar sweetened beverages and fatty liver disease: Rising concern and call to action." Journal of Hepatology 63, no. 2 (August 2015): 306-308. Full Text
  - Deng, Y, Palmeri, ML, Rouze, NC, Rosenzweig, SJ, Abdelmalek, MF, and Nightingale, KR. "Analyzing the Impact of Increasing Mechanical Index and Energy Deposition on Shear Wave Speed Reconstruction in Human Liver." Ultrasound in medicine & biology 41, no. 7 (July 2015): 1948-1957. Full Text
  - Guy, C, Suzuki, A, Abdelmalek, M, Burchette, J, and Diehl, AM. "Reply." Hepatology 61, no. 5 (May 2015): 1770-1771. Full Text
  - Neuschwander-Tetri, BA, Loomba, R, Sanyal, AJ, Lavine, JE, Van Natta, ML, Abdelmalek, MF, Chalasani, N, Dasarathy, S, Diehl, AM, Hameed, B, Kowdley, KV, McCullough, A, Terrault, N, Clark, JM, Tonascia, J, Brunt, EM, Kleiner, DE, Doo, E, and NASH Clinical Research Network, . "Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial." Lancet (London, England) 385, no. 9972 (March 2015): 956-965. Full Text
  - Guy, CD, Suzuki, A, Abdelmalek, MF, Burchette, JL, Diehl, AM, and NASH CRN, . "Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity." Hepatology (Baltimore, Md.) 61, no. 1 (January 2015): 98-107. Full Text
  - Guy, CD, Suzuki, A, Abdelmalek, MF, Burchette, JL, and Diehl, AM. "Treatment response in the PIVENS trial is associated with decreased hedgehog pathway activity." Hepatology 61, no. 1 (January 1, 2015): 98-107. Full Text
  - Nightingale, KR, Rouze, NC, Rosenzweig, SJ, Wang, MH, Abdelmalek, MF, Guy, CD, and Palmeri, ML. "Derivation and analysis of viscoelastic properties in human liver: impact of frequency on fibrosis and steatosis staging." Ieee Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 62, no. 1 (January 2015): 165-175. Full Text
  - Bohinc, BN, Michelotti, G, Xie, G, Pang, H, Suzuki, A, Guy, CD, Piercy, D, Kruger, L, Swiderska-Syn, M, Machado, M, Pereira, T, Zavacki, AM, Abdelmalek, M, and Diehl, AM. "Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism." Endocrinology 155, no. 11 (November 2014): 4591-4601. Full Text
  - Sanyal, AJ, Abdelmalek, MF, Suzuki, A, Cummings, OW, Chojkier, M, and EPE-A Study Group, . "No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial." Gastroenterology 147, no. 2 (August 2014): 377-84.e1. Full Text
  - Siddique, A, Nelson, JE, Aouizerat, B, Yeh, MM, Kowdley, KV, and NASH Clinical Research Network, . "Iron deficiency in patients with nonalcoholic Fatty liver disease is associated with obesity, female gender, and low serum hepcidin." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 12, no. 7 (July 2014): 1170-1178. Full Text
  - Gadd, VL, Skoien, R, Powell, EE, Fagan, KJ, Winterford, C, Horsfall, L, Irvine, K, and Clouston, AD. "The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease." Hepatology 59, no. 4 (April 2014): 1393-1405. Full Text
  - Moylan, CA, Pang, H, Dellinger, A, Suzuki, A, Garrett, ME, Guy, CD, Murphy, SK, Ashley-Koch, AE, Choi, SS, Michelotti, GA, Hampton, DD, Chen, Y, Tillmann, HL, Hauser, MA, Abdelmalek, MF, and Diehl, AM. "Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease." Hepatology 59, no. 2 (February 2014): 471-482. Full Text Link to Item
  - Yang, JD, Abdelmalek, MF, Pang, H, Guy, CD, Smith, AD, Diehl, AM, and Suzuki, A. "Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis." Hepatology 59, no. 4 (January 1, 2014): 1406-1414. Full Text
  - Sanyal, AJ, Abdelmalek, MF, Suzuki, A, Cummings, O, and Chojkier, M. "A Phase 2B Double-Blind Placebo Controlled Study of Two Doses of EPA-E in Patients With Nonalcoholic Steatohepatitis." HEPATOLOGY 58, no. 6 (December 2013): 1385A-1385A. Link to Item
  - Ishimoto, T, Lanaspa, MA, Rivard, CJ, Roncal-Jimenez, CA, Orlicky, DJ, Cicerchi, C, McMahan, RH, Abdelmalek, MF, Rosen, HR, Jackman, MR, MacLean, PS, Diggle, CP, Asipu, A, Inaba, S, Kosugi, T, Sato, W, Maruyama, S, Sánchez-Lozada, LG, Sautin, YY, Hill, JO, Bonthron, DT, and Johnson, RJ. "High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase." Hepatology (Baltimore, Md.) 58, no. 5 (November 2013): 1632-1643. Full Text
  - Ishimoto, T, Lanaspa, MA, Rivard, CJ, Roncal-Jimenez, CA, Orlicky, DJ, Cicerchi, C, Mcmahan, RH, Abdelmalek, MF, Rosen, HR, Jackman, MR, Maclean, PS, Diggle, CP, Asipu, A, Inaba, S, Kosugi, T, Sato, W, Maruyama, S, Sánchez-Lozada, LG, Sautin, YY, Hill, JO, Bonthron, DT, and Johnson, RJ. "High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase." Hepatology 58, no. 5 (November 1, 2013): 1632-1643. Full Text
  - Murphy, SK, Yang, H, Moylan, CA, Pang, H, Dellinger, A, Abdelmalek, MF, Garrett, ME, Ashley-Koch, A, Suzuki, A, Tillmann, HL, Hauser, MA, and Diehl, AM. "Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease." Gastroenterology 145, no. 5 (November 2013): 1076-1087. Full Text Link to Item
  - Youssef, NA, Abdelmalek, MF, Binks, M, Guy, CD, Omenetti, A, Smith, AD, Diehl, AME, and Suzuki, A. "Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease." Liver Int 33, no. 7 (August 2013): 1062-1070. Full Text Link to Item
  - Swiderska-Syn, M, Suzuki, A, Guy, CD, Schwimmer, JB, Abdelmalek, MF, Lavine, JE, and Diehl, AM. "Hedgehog pathway and pediatric nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 57, no. 5 (May 2013): 1814-1825. Full Text
  - Corbin, KD, Abdelmalek, MF, Spencer, MD, da Costa, K-A, Galanko, JA, Sha, W, Suzuki, A, Guy, CD, Cardona, DM, Torquati, A, Diehl, AM, and Zeisel, SH. "Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis." Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology 27, no. 4 (April 2013): 1674-1689. Full Text
  - Garrett, ME, Abdelmalek, MF, Ashley-Koch, A, Hauser, MA, Moylan, CA, Pang, H, Diehl, AM, and Tillmann, HL. "IL28B rs12979860 is not associated with histologic features of NAFLD in a cohort of Caucasian North American patients." J Hepatol 58, no. 2 (February 2013): 402-403. (Letter) Full Text Link to Item
  - Garrett, ME, Abdelmalek, MF, Ashley-Koch, A, Hauser, MA, Moylan, CA, Pang, H, Diehl, AM, and Tillmann, HL. "IL28B rs12979860 is not associated with histologic features of NAFLD in a cohort of Caucasian North American patients." Journal of Hepatology 58, no. 2 (2013): 402-403. Full Text
  - Swiderska-Syn, M, Suzuki, A, Guy, CD, Schwimmer, JB, Abdelmalek, MF, Lavine, JE, and Diehl, AM. "Hedgehog pathway and pediatric nonalcoholic fatty liver disease." Hepatology 57, no. 5 (2013): 1814-1825. Full Text
  - Youssef, NA, Abdelmalek, MF, Binks, M, Guy, CD, Omenetti, A, Smith, AD, Diehl, AME, and Suzuki, A. "Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease." Liver International 33, no. 7 (2013): 1062-1070. Full Text
  - Abdelmalek, MF, Lazo, M, Horska, A, Bonekamp, S, Lipkin, EW, Balasubramanyam, A, Bantle, JP, Johnson, RJ, Diehl, AM, Clark, JM, and Fatty Liver Subgroup of Look AHEAD Research Group, . "Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes." Hepatology (Baltimore, Md.) 56, no. 3 (September 2012): 952-960. Full Text
  - Syn, W-K, Agboola, KM, Swiderska, M, Michelotti, GA, Liaskou, E, Pang, H, Xie, G, Philips, G, Chan, IS, Karaca, GF, Pereira, TDA, Chen, Y, Mi, Z, Kuo, PC, Choi, SS, Guy, CD, Abdelmalek, MF, and Diehl, AM. "NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease." Gut 61, no. 9 (September 2012): 1323-1329. Full Text
  - Suzuki, A, Abdelmalek, MF, Schwimmer, JB, Lavine, JE, Scheimann, AO, Unalp-Arida, A, Yates, KP, Sanyal, AJ, Guy, CD, Diehl, AM, and Nonalcoholic Steatohepatitis Clinical Research Network, . "Association between puberty and features of nonalcoholic fatty liver disease." Clin Gastroenterol Hepatol 10, no. 7 (July 2012): 786-794. Full Text Link to Item
  - Guy, CD, Suzuki, A, Burchette, JL, Brunt, EM, Abdelmalek, MF, Cardona, D, McCall, SJ, Ünalp, A, Belt, P, Ferrell, LD, Diehl, AM, and Nonalcoholic Steatohepatitis Clinical Research Network, . "Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease." Hum Pathol 43, no. 6 (June 2012): 790-800. Full Text Link to Item
  - Guy, CD, Suzuki, A, Zdanowicz, M, Abdelmalek, MF, Burchette, J, Unalp, A, Diehl, AM, and NASH CRN, . "Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 55, no. 6 (June 2012): 1711-1721. Full Text
  - Abdelmalek, MF, Humar, A, Stickel, F, Andreone, P, Pascher, A, Barroso, E, Neff, GW, Ranjan, D, Toselli, LT, Gane, EJ, Scarola, J, Alberts, RG, Maller, ES, Lo, C-M, and Sirolimus Liver Conversion Trial Study Group, . "Sirolimus conversion regimen versus continued calcineurin inhibitors in liver allograft recipients: a randomized trial." Am J Transplant 12, no. 3 (March 2012): 694-705. Full Text Link to Item
  - Nelson, JE, Brunt, EM, Kowdley, KV, Abrams, SH, Fairly, LA, McCullough, AJ, Brandt, P, Bringman, D, Dasarathy, S, Dasarathy, J, Hawkins, C, Liu, Y-C, Rogers, N, Stager, M, Whitwell, J, McCullough, AJ, Dasarathy, S, Pagadala, M, Sargent, R, Yerian, L, Zein, C, Merriman, R, Nguyen, A, Mohan, P, Nair, K, DeVore, S, Kohli, R, Lake, K, Xanthakos, S, Cosme, Y, Lavine, JE, Mencin, A, Ovchinsky, N, Abdelmalek, MF, Buie, S, Diehl, AM, Gottfried, M, Guy, C, Hanna, M, Kigongo, C, Killenberg, P, and Kwan, S et al. "Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations." Hepatology 56, no. 5 (2012): 1730-1740. Full Text
  - Palmeri, ML, Abdelmalek, MF, and Nightingale, KR. "Reply to: The use of acoustic radiation force-based shear stiffness in non-alcoholic fatty liver disease." Journal of Hepatology 56, no. 4 (2012): 996--. Full Text
  - Ratziu, V, Sheikh, MY, Sanyal, AJ, Lim, JK, Conjeevaram, H, Chalasani, N, Abdelmalek, M, Bakken, A, Renou, C, Palmer, M, Levine, RA, Bhandari, BR, Cornpropst, M, Liang, W, King, B, Mondou, E, Rousseau, FS, Mchutchison, J, and Chojkier, M. "A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis." Hepatology 55, no. 2 (2012): 419-428. Full Text
  - Syn, W-K, Agboola, KM, Swiderska, M, Michelotti, GA, Liaskou, E, Pang, H, Xie, G, Philips, G, Chan, IS, Karaca, GF, Pereira, TDA, Chen, Y, Mi, Z, Kuo, PC, Choi, SS, Guy, CD, Abdelmalek, MF, and Diehl, AM. "NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease." Gut (2012). Full Text
  - Vos, MB, Colvin, R, Belt, P, Molleston, JP, Murray, KF, Rosenthal, P, Schwimmer, J, Tonascia, J, Unalp, A, Lavine, JE, Abrams, S, Arceo, D, Espinosa, D, Fairly, LA, Hawkins, C, Liu, YC, Stager, M, McCullough, A, Dasarathy, S, Sargent, R, Coffey, M, Young, M, Mohan, P, Nair, K, Abdelmalek, M, Diehl, AM, Gottfried, M, Guy, C, Killenberg, P, Kwan, S, Pan, YP, Piercy, D, Smith, M, Bhimalli, P, Chalasani, N, Cummings, OW, Lee, L, Ragozzino, L, Vuppalanchi, R, Byam, E, Klipsch, A, Subbarao, G, Pfeifer, K, Scheimann, A, Torbenson, M, Barlow, S, Derdoy, J, Hoffmann, J, King, D, Morris, A, Siegner, J, Stewart, S, Tetri, BA, Thompson, J, Behling, C, Clark, L, Durelle, J, Hassanein, T, Mendoza, S, Sirlin, C, Stein, T, Palomares, Z, Aouizerat, B, Bambha, K, Bass, NM, Ferrell, LD, Filipowski, D, Merriman, R, Pabst, M, Rosenthal, M, Steel, T, Yeh, M, Boyett, S, Contos, MJ, Fuchs, M, Jones, A, Luketic, VAC, Sandhu, B, Sanyal, AJ, Sargeant, C, Selph, K, White, M, Kowdley, KV, Mooney, J, Nelson, J, Ackermann, S, Saunders, C, Trinh, V, Wang, C, Brunt, EM, Kleiner, D, Grave, GD, and Huang, TTK. "Correlation of Vitamin E, uric acid and diet composition with histologic features of pediatric nonalcoholic fatty liver disease." Journal of Pediatric Gastroenterology and Nutrition 54, no. 1 (January 1, 2012): 90-96. Full Text
  - Palmeri, ML, Wang, MH, Rouze, NC, Abdelmalek, MF, Guy, CD, Moser, B, Diehl, AM, and Nightingale, KR. "Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease." Journal of Hepatology 55, no. 3 (September 2011): 666-672. Full Text
  - Rangwala, F, Guy, CD, Lu, J, Suzuki, A, Burchette, JL, Abdelmalek, MF, Chen, W, and Diehl, AM. "Increased production of sonic hedgehog by ballooned hepatocytes." J Pathol 224, no. 3 (July 2011): 401-410. Full Text Link to Item
  - Speliotes, EK, Yerges-Armstrong, LM, Wu, J, Hernaez, R, Kim, LJ, Palmer, CD, Gudnason, V, Eiriksdottir, G, Garcia, ME, Launer, LJ, Nalls, MA, Clark, JM, Mitchell, BD, Shuldiner, AR, Butler, JL, Tomas, M, Hoffmann, U, Hwang, S-J, Massaro, JM, O'Donnell, CJ, Sahani, DV, Salomaa, V, Schadt, EE, Schwartz, SM, Siscovick, DS, NASH CRN, , GIANT Consortium, , MAGIC Investigators, , Voight, BF, Carr, JJ, Feitosa, MF, Harris, TB, Fox, CS, Smith, AV, Kao, WHL, Hirschhorn, JN, Borecki, IB, and GOLD Consortium, . "Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits." Plos Genetics 7, no. 3 (March 10, 2011): e1001324-null. Full Text
  - Syn, W-K, Choi, SS, Liaskou, E, Karaca, GF, Agboola, KM, Oo, YH, Mi, Z, Pereira, TA, Zdanowicz, M, Malladi, P, Chen, Y, Moylan, C, Jung, Y, Bhattacharya, SD, Teaberry, V, Omenetti, A, Abdelmalek, MF, Guy, CD, Adams, DH, Kuo, PC, Michelotti, GA, Whitington, PF, and Diehl, AM. "Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis." Hepatology (Baltimore, Md.) 53, no. 1 (January 2011): 106-115. Full Text
  - Suzuki, A, Abdelmalek, MF, Unalp-Arida, A, Yates, K, Sanyal, A, Guy, C, and Diehl, AM. "Regional anthropometric measures and hepatic fibrosis in patients with nonalcoholic Fatty liver disease." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 8, no. 12 (December 2010): 1062-1069. Full Text
  - Abdelmalek, MF, Suzuki, A, Guy, C, Unalp-Arida, A, Colvin, R, Johnson, RJ, Diehl, AM, and Nonalcoholic Steatohepatitis Clinical Research Network, . "Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease." Hepatology (Baltimore, Md.) 51, no. 6 (June 2010): 1961-1971. Full Text
  - Corbin, KD, Spencer, MD, da Costa, K-A, Sha, W, Abdelmalek, MF, Pan, Y, Suzuki, A, Guy, CD, Cardona, DM, Torquati, A, Diehl, AM, and Zeisel, SH. "Genotype-based hierarchical clustering reveals a panel of polymorphisms in one carbon metabolism that are associated with obesity." FASEB JOURNAL 24 (April 2010). Link to Item
  - Abdelmalek, MF. "Is oil red-O staining and digital image analysis the gold standard for quantifying steatosis in the liver? Reply." Hepatology 51, no. 5 (2010): 1859-1860. Full Text
  - Lavine, JE, Schwimmer, JB, Molleston, JP, Scheimann, AO, Murray, KF, Abrams, SH, Rosenthal, P, Sanyal, AJ, Robuck, PR, Brunt, EM, Unalp, A, Tonascia, J, and Nonalcoholic Steatohepatitis Clinical Research Network Research Group, . "Treatment of nonalcoholic fatty liver disease in children: TONIC trial design." Contemporary Clinical Trials 31, no. 1 (January 2010): 62-70. Full Text
  - Sánchez-Lozada, LG, Mu, W, Roncal, C, Sautin, YY, Abdelmalek, M, Reungjui, S, Le, M, Nakagawa, T, Lan, HY, Yu, X, and Johnson, RJ. "Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver." European Journal of Nutrition 49, no. 1 (2010): 1-9. Full Text
  - Abdelmalek, MF, Sanderson, SO, Angulo, P, Soldevila-Pico, C, Liu, C, Peter, J, Keach, J, Cave, M, Chen, T, McClain, CJ, and Lindor, KD. "Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial." Hepatology (Baltimore, Md.) 50, no. 6 (December 2009): 1818-1826. Full Text
  - Shah, AG, Lydecker, A, Murray, K, Tetri, BN, Contos, MJ, Sanyal, AJ, and Nash Clinical Research Network, . "Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 7, no. 10 (October 2009): 1104-1112. Full Text
  - Syn, W-K, Jung, Y, Omenetti, A, Abdelmalek, M, Guy, CD, Yang, L, Wang, J, Witek, RP, Fearing, CM, Pereira, TA, Teaberry, V, Choi, SS, Conde-Vancells, J, Karaca, GF, and Diehl, AM. "Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease." Gastroenterology 137, no. 4 (October 2009): 1478-1488.e8. Full Text Link to Item
  - Brunt, EM, Kleiner, DE, Wilson, LA, Unalp, A, Behling, CE, Lavine, JE, Neuschwander-Tetri, BA, and NASH Clinical Research NetworkA list of members of the Nonalcoholic Steatohepatitis Clinical Research Network can be found in the Appendix, . "Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network." Hepatology (Baltimore, Md.) 49, no. 3 (March 2009): 809-820. Full Text
  - Suzuki, A, and Abdelmalek, MF. "Nonalcoholic fatty liver disease in women." Womens Health (Lond) 5, no. 2 (March 2009): 191-203. (Review) Full Text Link to Item
  - Ouyang, X, Cirillo, P, Sautin, Y, McCall, S, Bruchette, JL, Diehl, AM, Johnson, RJ, and Abdelmalek, MF. "Fructose consumption as a risk factor for non-alcoholic fatty liver disease." Journal of Hepatology 48, no. 6 (June 2008): 993-999. Full Text
  - Abdelmalek, MF, and Diehl, AM. "Nonalcoholic fatty liver disease as a complication of insulin resistance." The Medical Clinics of North America 91, no. 6 (November 2007): 1125-ix. (Review) Full Text
  - Purohit, V, Abdelmalek, MF, Barve, S, Benevenga, NJ, Halsted, CH, Kaplowitz, N, Kharbanda, KK, Liu, Q-Y, Lu, SC, McClain, CJ, Swanson, C, and Zakhari, S. "Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium." The American Journal of Clinical Nutrition 86, no. 1 (July 2007): 14-24. (Review) Full Text
  - Abdelmalek, MF, Liu, C, and Valentine, JF. "Successful treatment of chronic hepatitis C with pegylated interferon, ribavirin, and infliximab in a patient with Crohn's disease." The American Journal of Gastroenterology 102, no. 6 (June 2007): 1333-1334. (Letter) Full Text
  - Abdelmalek, MF, and Diehl, AM. "De novo nonalcoholic fatty liver disease after liver transplantation." Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 13, no. 6 (June 2007): 788-790. Full Text
  - Abdelmalek, MF, Hellner, LB, Zumberg, M, Melgen, VW, and Lottenberg, R. "Acute liver failure occurring immediately following anti-D immune globulin infusion in a patient with chronic hepatitis B infection." Dig Dis Sci 52, no. 4 (April 2007): 914-919. Full Text Link to Item
  - Galhenage, S, Patel, K, Patton, HM, Walker, T, Symonds, W, Abdelmalek, MF, and Mchutchison, JG. "The association of adipokine levels with changes in steatosis following treatment in patients with chronic hepatitis C infection." GASTROENTEROLOGY 132, no. 4 (April 2007): A783-A783. Link to Item
  - Galhenage, S, and Abdelmalek, MF. "The impact of steatosis and alcohol on hepatitis C." Current Hepatitis Reports 6, no. 2 (2007): 39-45.
  - Palmeri, ML, Wang, MH, Frinkley, KD, Nightingale, KR, Abdelmalek, MF, and Diehl, AM. "Dependence of in vivo, radiation force derived hepatic shear modulus estimates on imaging approach: Intercostal vs. subcostal." Proceedings - IEEE Ultrasonics Symposium (2007): 566-569. Full Text
  - Abdelmalek, MF, Liu, C, Shuster, J, Nelson, DR, and Asal, NR. "Familial aggregation of insulin resistance in first-degree relatives of patients with nonalcoholic fatty liver disease." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 4, no. 9 (September 2006): 1162-1169. Full Text
  - Samara, K, Liu, C, Soldevila-Pico, C, Nelson, DR, and Abdelmalek, MF. "Betaine resolves severe alcohol-induced hepatitis and steatosis following liver transplantation." Digestive Diseases and Sciences 51, no. 7 (July 2006): 1226-1229. Full Text
  - Machicao, VI, Srinivas, TR, Hemming, AW, Soldevila-Pico, C, Firpi, RJ, Reed, AI, Morelli, GJ, Nelson, DR, and Abdelmalek, MF. "Impact of implementation of the MELD scoring system on the prevalence and incidence of chronic renal disease following liver transplantation." Liver Transpl 12, no. 5 (May 2006): 754-761. Full Text Link to Item
  - Morelli, G, Reed, A, Firpi, RJ, Machicao, V, Abdelmalek, MF, Soldevilla-Pico, C, and Nelson, DR. "Late presentation of a biliary tract complication after right hepatic donation resulting in secondary biliary cirrhosis." Liver Transpl 12, no. 2 (February 2006): 306-309. Full Text Link to Item
  - Abdelmalek, MF, and Diehl, AM. "Mechanisms underlying nonalcoholic steatohepatitis." Drug Discovery Today: Disease Mechanisms 3, no. 4 (2006): 479-488. Full Text
  - Firpi, RJ, Zhu, H, Morelli, G, Abdelmalek, MF, Soldevila-Pico, C, Machicao, VI, Cabrera, R, Reed, AI, Liu, C, and Nelson, DR. "Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation." Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 12, no. 1 (January 2006): 51-57. Full Text
  - Firpi, RJ, Soldevila-Pico, C, Abdelmalek, MF, Morelli, G, Judah, J, and Nelson, DR. "Short recovery time after percutaneous liver biopsy: should we change our current practices?." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association 3, no. 9 (September 2005): 926-929. Full Text
  - Lucey, MR, Abdelmalek, MF, Gagliardi, R, Granger, D, Holt, C, Kam, I, Klintmalm, G, Langnas, A, Shetty, K, Tzakis, A, and Woodle, ES. "A comparison of tacrolimus and cyclosporine in liver transplantation: effects on renal function and cardiovascular risk status." Am J Transplant 5, no. 5 (May 2005): 1111-1119. Full Text Link to Item
  - Reed, A, Howard, RJ, Fujita, S, Foley, DP, Langham, MR, Schold, JD, Nelson, D, Soldevila-Pico, C, Firpi, R, Abdelmalek, M, Morrelli, G, and Hemming, AW. "Liver retransplantation: A single-center outcome and financial analysis." Transplantation Proceedings 37, no. 2 (2005): 1161-1163. Full Text
  - Firpi, RJ, Abdelmalek, MF, Soldevila-Pico, C, Cabrera, R, Shuster, JJ, Theriaque, D, Reed, AI, Hemming, AW, Liu, C, Crawford, JM, and Nelson, DR. "One-year protocol liver biopsy can stratify fibrosis progression in liver transplant recipients with recurrent hepatitis C infection." Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 10, no. 10 (October 2004): 1240-1247. Full Text
  - Abdelmalek, MF, Firpi, RJ, Soldevila-Pico, C, Reed, AI, Hemming, AW, Liu, C, Crawford, JM, Davis, GL, and Nelson, DR. "Sustained viral response to interferon and ribavirin in liver transplant recipients with recurrent hepatitis C." Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 10, no. 2 (February 2004): 199-207. Full Text
  - Abdelmalek, MF, Pasha, TM, Zein, NN, Persing, DH, Wiesner, RH, and Douglas, DD. "Subclinical reactivation of hepatitis B virus in liver transplant recipients with past exposure." Liver Transpl 9, no. 12 (December 2003): 1253-1257. Full Text Link to Item
  - Nelson, DR, Tu, Z, Soldevila-Pico, C, Abdelmalek, M, Zhu, H, Xu, YL, Cabrera, R, Liu, C, and Davis, GL. "Long-term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti-inflammatory effect." Hepatology (Baltimore, Md.) 38, no. 4 (October 2003): 859-868. Full Text
  - Rosenberg, EI, Mishra, G, and Abdelmalek, MF. "Angiotensin-converting enzyme inhibitor-induced isolated visceral angioedema in a liver transplant recipient." Transplantation 75, no. 5 (March 2003): 730-732. Full Text
  - Firpi, RJ, Abdelmalek, MF, Soldevila-Pico, C, Reed, A, Hemming, A, Howard, R, Van Der Werf, W, Lauwers, G, Liu, C, Crawford, JM, Davis, GL, and Nelson, DR. "Combination of interferon alfa-2b and ribavirin in liver transplant recipients with histological recurrent hepatitis C." Liver Transpl 8, no. 11 (November 2002): 1000-1006. Full Text Link to Item
  - Nelson, DR, Soldevila-Pico, C, Reed, A, Abdelmalek, MF, Hemming, AW, Van der Werf, WJ, Howard, R, and Davis, GL. "Anti-interleukin-2 receptor therapy in combination with mycophenolate mofetil is associated with more severe hepatitis C recurrence after liver transplantation." Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 7, no. 12 (December 2001): 1064-1070. Full Text
  - Abdelmalek, MF, Angulo, P, Jorgensen, RA, Sylvestre, PB, and Lindor, KD. "Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study." Am J Gastroenterol 96, no. 9 (September 2001): 2711-2717. Full Text Link to Item
  - Maiwald, M, von Herbay, A, Persing, DH, Mitchell, PP, Abdelmalek, MF, Thorvilson, JN, Fredricks, DN, and Relman, DA. "Tropheryma whippelii DNA is rare in the intestinal mucosa of patients without other evidence of Whipple disease." Annals of Internal Medicine 134, no. 2 (January 2001): 115-119. Full Text
  - O'Duffy, JD, Griffing, WL, Li, CY, Abdelmalek, MF, and Persing, DH. "Whipple's arthritis: direct detection of Tropheryma whippelii in synovial fluid and tissue." Arthritis and Rheumatism 42, no. 4 (April 1999): 812-817. Full Text
  - Abdelmalek, MF, Harrison, ME, Gross, JB, Poterucha, JJ, Gossard, AA, Spivey, JR, Rakela, J, and Lindor, KD. "Treatment of chronic hepatitis C with interferon with or without ursodeoxycholic acid: a randomized prospective trial." Journal of Clinical Gastroenterology 26, no. 2 (March 1998): 130-134. Full Text
  - Abdelmalek, MF, Pockaj, BA, and Leighton, JA. "Rectal bleeding from a mucous fistula secondary to a Dieulafoy's lesion." J Clin Gastroenterol 24, no. 4 (June 1997): 259-261. Link to Item
  - Abdelmalek, MF, and Douglas, DD. "Lisinopril-induced isolated visceral angioedema: review of ACE-inhibitor-induced small bowel angioedema." Dig Dis Sci 42, no. 4 (April 1997): 847-850. (Review) Link to Item
  - Abdelmalek, MF, and Douglas, DD. "Alendronate-induced ulcerative esophagitis." Am J Gastroenterol 91, no. 6 (June 1996): 1282-1283. (Letter) Link to Item
  - Abdelmalek, MF, and Spittell, PC. "79-year-old woman with blue toes." Mayo Clinic Proceedings 70, no. 3 (March 1995): 292-295. Full Text
  - Abdelmalek, M, Ludwig, J, and Lindor, KD. "Two cases from the spectrum of nonalcoholic steatohepatitis." Journal of Clinical Gastroenterology 20, no. 2 (1995): 127-130.
- Conference Papers
  - Abdelmalek, MF, Freilich, BL, Harrison, SA, Powell, EE, Rinella, MEM, Tobis, N, Peres, D, Kanellos, J, Lalazar, G, and Sanyal, AJ. "Imm-124E Improves Metabolic Endotoxemia and Markers of Liver Injury in Nonalcoholic Steatohepatitis." Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting. San Francisco, CA. November 9, 2018 - November 13, 2018.: WILEY, October 1, 2018. Link to Item
  - Abdelmalek, MF, Lanthier, N, Chojkier, M, Kluwe, J, Fowell, AJ, Yuan, J, Nicandro, JP, Seyedkazemi, S, Fischer, L, Goodman, ZD, and Harrison, SA. "Cenicriviroc Treatment over 2 Years Results in Clinically Meaningful and Sustained Improvement in Fibrosis in Adults with Nonalcoholic Steatohepatitis and Severe Liver Fibrosis." Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting. San Francisco, CA. November 9, 2018 - November 13, 2018.: WILEY, October 1, 2018. Link to Item
  - Chalasani, NP, Lawitz, EJ, Abdelmalek, MF, Rinella, MEM, Harrison, SA, Sanyal, AJ, Noureddin, M, Rockey, DC, Ber, TI, Ilan, Y, Garcia-Tsao, G, and Traber, PG. "The Noninvasive Point of Care MBT Accurately Predicts Decompensation Events Better Than MELD in Compensated (MELD < 15) Nash Cirrhotics." Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting. San Francisco, CA. November 9, 2018 - November 13, 2018.: WILEY, October 1, 2018. Link to Item
  - Chaudhry, M, Moylan, CA, Middleton, MS, Farjat, A, Chaudhury, KR, Guy, CD, Abdelmalek, MF, Loomba, R, Sirlin, CB, and Bashir, M. "Quantifying the Placebo Effect on Liver Fat Using Magnetic Resonance Imaging-Proton Density Fat Fraction in NAFLD Clinical Trials." Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting. San Francisco, CA. November 9, 2018 - November 13, 2018.: WILEY, October 1, 2018. Link to Item
  - Halegoua-De Marzio, D, Thuluvath, PJ, Abdelmalek, MF, Van Biene, C, Shringarpure, R, and MacConell, L. "Obeticholic Acid Was Safe and Well Tolerated in Patients with Nonalcoholic Steatohepatitis and Compensated Cirrhosis: A Secondary Analysis of the Control Study." Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting. San Francisco, CA. November 9, 2018 - November 13, 2018.: WILEY, October 1, 2018. Link to Item
  - Moylan, CA, Sorrow, PA, Mavis, A, Bashir, M, Jima, D, Maguire, R, Bozdogan, E, Buie, S, Murphy, SK, Diehl, AM, Hoyo, C, and Abdelmalek, MF. "Obesity and Nonalcoholic Fatty Liver Disease in Childhood Associate with Altered DNA Methylation in Early Life." Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting. San Francisco, CA. November 9, 2018 - November 13, 2018.: WILEY, October 1, 2018. Link to Item
  - Neuschwander-Tetri, BA, Kowdley, KV, Sanyal, AJ, Abdelmalek, MF, Terrault, N, McCullough, AJ, Wang, P, Shringarpure, R, MacCone, L, Shapiro, DA, and Loomba, R. "Efficacy and Safety of Obeticholic Acid in Patients with Non-Alcoholic Steatohepatitis and Significant Fibrosis Using Endpoint Definitions and Populations Accepted for Registrational Studies." Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting. San Francisco, CA. November 9, 2018 - November 13, 2018.: WILEY, October 1, 2018. Link to Item
  - Schild, M, Xu, L, Suzuki, A, Cardona, D, Clinton, L, McCall, S, Pendse, A, Zhang, X, Abdelmalek, MF, Diehl, AM, and Guy, C. "Sonic Hedgehog Immunohistochemistry Improves Inter-observer Agreement for Ballooning and the Diagnosis of Nonalcoholic Steatohepatitis (NASH) among Less Experienced Liver Pathologists." 107th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP). Vancouver, CANADA. March 17, 2018 - March 23, 2018.: NATURE PUBLISHING GROUP, March 1, 2018. Link to Item
  - de Ridder, G, Suzuki, A, Xu, L, Cardona, D, Groth, J, Ray, R, Abdelmalek, MF, Pizzo, SV, and Guy, C. "GRP78 Immunohistochemistry Outperforms HSP70 for the Diagnosis of Cirrhotic- and Noncirrhotic-HCC." 107th Annual Meeting of the United-States-and-Canadian-Academy-of-Pathology (USCAP). Vancouver, CANADA. March 17, 2018 - March 23, 2018.: NATURE PUBLISHING GROUP, March 1, 2018. Link to Item
  - Abdelmalek, MF, Charles, ED, Neuschwander-Tetri, BA, Halegoua-DeMarzio, D, Sanyal, AJ, Herring, RW, Lawitz, E, Dong, Y, Du, S, Gagnon, RC, Luo, Y, and Christian, R. "Baseline Serum Pro-C3 Predicts Response to BMS-986036 (peg-FGF21): A Secondary Analysis of a Multi-Center Clinical Trial in Non-Alcoholic Steatohepatitis (NASH)." October 2017. Link to Item
  - Abdelmalek, MF, Diehl, AM, Guy, CD, Portenier, D, Sudan, R, Li, X, Mimms, L, and Jain, A. "Serum-Based Biomarker Accurately Stratifies Hepatic Fibrosis in Patients with Nonalcoholic Steatohepatitis." October 2017. Link to Item
  - Abdelmalek, MF, Henao, R, Wang, Y, Guy, CD, Bashir, MR, Johnson, R, Diehl, AM, and Soher, B. "Fructose-Related Hepatic ATP Depletion Induces Hyperuricemia in Healthy Volunteers and Patients with Biopsy-Proven Nonalcoholic Fatty Liver Disease." October 2017. Link to Item
  - Abdelmalek, MF, Thompson, M, Gathe, JC, Lefebvre, E, Seyedkazemi, S, Utay, NS, and Francque, S. "Favorable safety and tolerability of the dual CCR2/5 antagonist cenicriviroc in over 1000 subjects treated to date." October 2017. Link to Item
  - Bosch, J, Abdelmalek, MF, Shiffman, ML, Diehl, AM, Caldwell, SH, Rockey, DC, Ghalib, R, Thuluvath, PJ, Harrison, SA, Schall, REA, Jia, C, McColgan, BJ, Myers, RP, Subramanian, M, McHutchison, JG, Afdhal, NH, Ratziu, V, Goodman, ZD, and Sanyal, AJ. "Variability in measurement of hepatic venous pressure gradient (HVPG) in patients with compensated cirrhosis due to NASH: Results from a randomized, controlled trial." October 2017. Link to Item
  - Bosch, J, Harrison, SA, Abdelmalek, MF, Shiffman, ML, Diehl, AM, Caldwell, SH, Rockey, DC, Ghalib, R, Thuluvath, PJ, Schall, REA, Jia, C, McColgan, BJ, Myers, RP, Subramanian, M, McHutchison, JG, Afdhal, NH, Ratziu, V, Goodman, ZD, and Sanyal, AJ. "Hepatic venous pressure gradient (HVPG) predicts clinical disease progression in patients with compensated cirrhosis due to NASH." October 2017. Link to Item
  - Goodman, ZD, Alaparthi, L, Monge, F, Patel, K, Loomba, R, Caldwell, SH, Lawitz, E, Shiffman, ML, Abdelmalek, MF, Schall, REA, Jia, C, McColgan, BJ, Myers, RP, Ratziu, V, Afdhal, NH, Harrison, SA, and Sanyal, AJ. "Prospective validation of hepatic collagen content for the prediction of clinical disease progression." October 2017. Link to Item
  - Guy, CD, Suzuki, A, Swiderska-Syn, M, Abdelmalek, MF, and Diehl, AM. "Hepatocellular injury and senescence in NASH are linked to Hedgehog and Hippo pathway activity and accumulation of hepatic progenitor cells." October 2017. Link to Item
  - Harrison, SA, Abdelmalek, MF, Diehl, AM, Caldwell, S, Shiffman, ML, Ghalib, R, Lawitz, E, Rockey, DC, Schall, REA, Jia, C, McColgan, BJ, Myers, RP, Subramanian, M, McHutchison, JG, Muir, AJ, Ratziu, V, Afdhal, NH, Goodman, ZD, Bosch, J, and Sanyal, AJ. "Prospective validation of the Enhanced Liver Fibrosis (ELF) test for the prediction of disease progression in patients with nonalcoholic steatohepatitis (NASH) and advanced fibrosis." October 2017. Link to Item
  - Li, X, Moylan, CA, Baker, SS, Liu, W, Baker, RD, Murphy, SK, Abdelmalek, MF, Zhu, R, Diehl, AM, and Zhu, L. "Altered liver methylome and transcriptome provide evidence for epigenetic contribution to NAFLD pathogenesis." October 2017. Link to Item
  - Loomba, R, Abdelmalek, MF, Trotter, JF, Paredes, AH, Jaros, M, Ling, L, Rossi, SJ, DePaoli, AM, Rinella, ME, and Harrison, SA. "NGM282 Significantly Reduces Hepatic Steatosis Independent of Baseline Patient Characteristics and Highly Correlates with Markers of FGFR4 Target Engagement: Results from a Phase 2 Trial in Biopsy-Confirmed NASH Patients." October 2017. Link to Item
  - Loomba, R, Lawitz, E, Ghalib, R, Elkhashab, M, Caldwell, SH, Abdelmalek, MF, Kowdley, KV, Xu, R, Han, L, Li, Y, Djedjos, CS, Myers, RP, Subramanian, M, Goodman, ZD, Charlton, M, Sirlin, CB, and Middleton, MS. "Reductions in liver stiffness by magnetic resonance elastography (MRE) predict fibrosis improvement in a multi-center clinical trial of subjects with nonalcoholic steatohepatitis (NASH)." October 2017. Link to Item
  - Moylan, CA, Mavis, AM, Bashir, MR, Malik, D, Bozdogan, E, Buie, S, Hoyo, C, Diehl, AM, Murphy, SK, and Abdelmalek, MF. "Visceral and subcutaneous adipose tissue measurements associate with increased metabolic risk for NAFLD in pre-pubertal obese children." October 2017. Link to Item
  - Rinella, ME, Trotter, JF, Neff, G, Ortiz-Lasanta, G, Abdelmalek, MF, Kugelmas, M, Paredes, AH, Connelly, MA, Ling, L, Rossi, SJ, DePaoli, AM, Loomba, R, and Harrison, SA. "NGM282 Induces Low Density Lipoprotein Cholesterol (LDLc) Changes, Consistent with Potent FGFR4 Signaling, which are Rapidly Mitigated with Statin Therapy in Patients with Biopsy-Confirmed Nonalcoholic Steatohepatitis (NASH)." October 2017. Link to Item
  - Sanyal, AJ, Charles, ED, Neuschwander-Tetri, BA, Loomba, R, Harrison, SA, Abdelmalek, MF, Lawitz, E, Halegoua-DeMarzio, D, Dong, Y, Noviello, S, Luo, Y, and Christian, R. "BMS-986036 (pegylated FGF21) in patients with non-alcoholic steatohepatitis: A phase 2 study." October 2017. Link to Item
  - Vuppalanchi, R, Lawitz, E, Abdelmalek, MF, Rinella, ME, Harrison, SA, Ryan, MJ, Traber, PG, Garcia-Tsao, G, and Chalasani, NP. "Liver Stiffness Measured By Vibration Controlled Transient Elastography Is An Excellent Surrogate for Identifying Clinically Significant Portal Hypertension In Patients With Compensated NASH Cirrhosis." October 2017. Link to Item
  - Wegermann, K, Moylan, CA, Zheng, J, Abdelmalek, MF, Chow, S-C, Guy, CD, Diehl, AM, and Suzuki, A. "Gender and menopause significantly modify effects of metabolism-related SNPs on fibrosis stage in adult patients with nonalcoholic fatty liver disease (NAFLD)." October 2017. Link to Item
  - Younossi, ZM, Stepanova, M, Harrison, SA, Sanyal, AJ, Ratziu, V, McColgan, BJ, Myers, RP, Subramanian, M, McHutchison, JG, Afdhal, NH, Abdelmalek, MF, Bosch, J, and Goodman, ZD. "Subjects with Non-alcoholic Fatty Liver Disease and Severe Fibrosis Face a Significant Number of Adverse Events: Cryptogenic Cirrhosis and Severe Steatofibrosis." October 2017. Link to Item
  - Younossi, ZM, Stepanova, M, Sanyal, AJ, Harrison, SA, Ratziu, V, McColgan, BJ, Myers, RP, Subramanian, M, McHutchison, JG, Afdhal, NH, Abdelmalek, MF, Bosch, J, and Goodman, ZD. "Predictors of Fibrosis Progression and Regression by Histology and Morphometrically Quantified Collagen in Patients with Nonalcoholic Steatohepatitis (NASH) and Advanced Fibrosis." October 2017. Link to Item
  - Moylan, CA, Giraldo, RH, Murphy, SK, Diehl, AM, and Abdelmalek, MF. "Differential DNA Methylation in Whole Blood Reflects that in Liver and Distinguishes Patients with Advanced NAFLD Fibrosis from Those with Normal Histology: A Potential Non-Invasive Tool." April 2017. Full Text
  - Sanyal, A, Harrison, SA, Ratziu, V, Abdelmalek, MF, Diehl, AM, Caldwell, SH, Shiffman, ML, Aguilar, R, Jia, C, McColgan, BJ, Natha, M, Myers, RP, Subramanian, M, McHutchison, J, Muir, AJ, Afdhal, NH, Bosch, J, and Goodman, Z. "Changes in Fibrosis, but not the Nafld Activity Score (NAS), are Associated with Disease Progression in Patients with Nonalcoholic Steatohepatitis (NASH) and Advanced Fibrosis." April 2017. Full Text
  - Sanyal, AJ, Ratziu, V, Harrison, S, Abdelmalek, MF, Aithal, GP, Caballeria, J, Francque, SM, Farrell, GC, Kowdley, KV, Craxi, A, Simon, K, Fischer, L, Melchor-Khan, L, Vest, J, Wiens, BL, Vig, P, Seyedkazemi, S, Goodman, ZD, Wong, VW, Loomba, R, Tacke, F, Friedman, SL, and Lefebvre, E. "Cenicriviroc placebo for the treatment of non-alcoholic steatohepatitis with liver fibrosis: Results from the Year 1 primary analysis of the Phase 2b CENTAUR study Abstracts." December 2016. Link to Item
  - Corey, KE, Yates, KP, Abdelmalek, MF, Sanyal, AJ, Tetri, BA, Kowdley, KV, Cummings, O, Tonascia, J, and Chalasani, NP. "Longitudinal relationship between changes in liver histology and renal function in adults with NASH: The NASH Clinical Research Network Experience." October 2016. Link to Item
  - Hameed, B, Terrault, N, Loomba, R, McCullough, AJ, Abdelmalek, MF, Kowdley, KV, Tetri, BA, Sanyal, AJ, Lee, L, Ferguson, B, Shringarpure, R, Shapiro, D, and Chalasani, NP. "Subgroup Analysis Comparing Obeticholic Acid versus Placebo for Fibrosis Improvement: a Post-hoc Analysis of the FLINT Trial." October 2016. Link to Item
  - Moylan, CA, Wegermann, KJ, Henao, RG, Murphy, SK, Diehl, AM, and Abdelmalek, MF. "BCAT1 Is Associated with Clinical Decompensation in Nonalcoholic Fatty Liver Disease: a Pilot Study." October 2016. Link to Item
  - Patel, YA, Henao, R, Moylan, CA, Guy, CD, Piercy, DL, Diehl, AM, and Abdelmalek, MF. "Vitamin D is Not Associated with Histologic Severity in NAFLD: Results of a Paired Clinical and Hepatic Gene Expression Profile Analysis." October 2016. Link to Item
  - Suzuki, A, Spencer, HJ, Moylan, CA, Dranoff, JA, Abdelmalek, MF, Guy, CD, and Diehl, AM. "Hepatic estrogen transcriptional activity and estrogen receptor a gene expression are negatively correlated with fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD)." October 2016. Link to Item
  - Vuppalanchi, R, Abdelmalek, MF, Lawitz, E, Traber, PG, Allgood, AE, Harrison, SA, Goodman, ZD, Chalasani, NP, and Garcia-Tsao, G. "Vibration-Controlled Transient Elastography (VCTE) is Useful in Identifying Clinically Significant Portal Hypertension in Patients with NASH Cirrhosis." October 2016. Link to Item
  - Wegermann, K, Henao, R, Pan, Y, Diehl, AM, Abdelmalek, MF, and Moylan, CA. "BCAT1 is Associated with Clinical Decompensation in NAFLD: A Pilot Study." October 2016. Link to Item
  - Kowdley, KV, Abdelmalek, MF, McCullough, A, Loomba, R, Hameed, B, Chalasani, NP, Neuschwander-Tetri, B, Hazra, S, Chen, J, Shringapure, R, Shapiro, D, and Sanyal, AJ. "Mo1557 Evaluation of Effects of Concomitant Medications for NASH and Associated Comorbidities on Histological Improvements With Obeticholic Acid." April 2016. Full Text
  - Abdelmalek, MF, Kowdley, KV, Terrault, N, Neuschwander-Tetri, BA, Sanyal, AJ, Loomba, R, Yan, X, Shringarpure, R, Shapiro, D, and McCullough, AJ. "Effect of biopsy length on histological response assessment in NASH trials: A secondary analysis of FLINT Trial." 66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD). San Francisco, CA. November 13, 2015 - November 17, 2015.: WILEY-BLACKWELL, October 1, 2015. Link to Item
  - Bosch, J, Ratziu, V, Rockey, DC, Ghalib, RH, Thuluvath, PJ, Schiefke, I, Flamm, SL, Abdelmalek, MF, Myers, RP, Schall, REA, Subramanian, M, McHutchison, JG, Goodman, ZD, Sanyal, AJ, and Afdhal, NH. "Correlation between noninvasive markers of fibrosis and the hepatic venous pressure gradient (HVPG) in patients with compensated cirrhosis due to nonalcoholic steatohepatitis (NASH)." October 2015. Link to Item
  - Chalasani, NP, Loomba, R, Terrault, N, McCullough, AJ, Abdelmalek, MF, Kowdley, KV, Neuschwander-Tetri, BA, Hazra, S, Yan, X, Shringarpure, R, MacConell, L, and Sanyal, AJ. "Longitudinal changes in FIB-4 and improvement in fibrosis stage with obeticholic acid: A secondary analysis of FLINT Trial." 66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD). San Francisco, CA. November 13, 2015 - November 17, 2015.: WILEY-BLACKWELL, October 1, 2015. Link to Item
  - Goodman, ZD, Alaparthi, L, Monge, F, Patel, K, Loomba, R, Caldwell, SH, Lawitz, E, Harrison, SA, Shiffman, ML, Abdelmalek, MF, Myers, RP, Schall, REA, Subramanian, M, McHutchison, JG, Ratziu, V, Sanyal, AJ, and Afdhal, NH. "Correlations between hepatic morphometric collagen content, histologic fibrosis staging, and serum markers in patients with advanced fibrosis due to nonalcoholic steatohepatitis (NASH)." October 2015. Link to Item
  - Harrison, SA, Goodman, ZD, Ratziu, V, Loomba, R, Diehl, AM, Lawitz, E, Hinrichsen, H, Bambha, K, Abdelmalek, MF, Myers, RP, Schall, REA, Subramanian, M, McHutchison, JG, Afdhal, NH, and Muir, AJ. "Serum lysyl oxidase-like-2 (sLOXL2) levels correlate with fibrosis stage in patients with nonalcoholic steatohepatitis (NASH)." October 2015. Link to Item
  - Harrison, SA, Sanyal, AJ, Francque, SM, Bedossa, P, Serfaty, L, Romero-Gomez, M, Cales, P, Abdelmalek, MF, Caldwell, SH, Drenth, J, Anstee, QM, Hum, DW, Hanf, R, Roudot, A, Megnien, S, Staels, B, and Ratziu, V. "Beneficial effects of the dual PPAR alpha-delta agonist, GFT505, on hepatic and cardiometabolic markers in adult NASH patients." October 2015. Link to Item
  - Hasanaliyeva, N, Patel, K, Guy, CD, Gruss, HJ, Streilein, R, Hall, R, Diehl, AM, and Abdelmalek, MF. "IL-8 and MCP1 are Independently Associated with Hepatic Fibrosis in Patients with Nonalcoholic Fatty Liver Disease." October 2015. Link to Item
  - Henao, R, Hasanaliyeva, N, Bell, LN, Wulff, J, Perichon, R, Moylan, CA, Lu, JT, Guy, CD, Diehl, AM, and Abdelmalek, MF. "Plasma Metabolomic Profiles Predict Advanced Hepatic Fibrosis in Patients with Nonalcoholic Fatty Liver Disease." October 2015. Link to Item
  - Loomba, R, Sanyal, AJ, Kowdley, KV, Terrault, N, Chalasani, NP, Abdelmalek, MF, McCullough, AJ, Yan, X, Shringarpure, R, Ferguson, B, Shapiro, D, and Neuschwander-Tetri, BA. "Predictors of improvement in NAFLD Activity Score to obeticholic acid: A secondary analysis of FLINT Trial." 66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD). San Francisco, CA. November 13, 2015 - November 17, 2015.: WILEY-BLACKWELL, October 1, 2015. Link to Item
  - Moylan, CA, Murphy, SK, Grenier, C, Abdelmalek, MF, and Diehl, AM. "DNA Methylation Profiles of Fibrosis-Associated Gene in Blood Reflects Liver Fibrosis Severity in Human Nonalcoholic Fatty Liver Disease." October 2015. Link to Item
  - Ratziu, V, Harrison, SA, Francque, SM, Bedossa, P, Serfaty, L, Romero-Gomez, M, Cales, P, Abdelmalek, MF, Caldwell, SH, Drenth, J, Anstee, QM, Hum, DW, Hanf, R, Roudot, A, Megnien, S, Staels, B, and Sanyal, AJ. "An international, phase 2 randomized controlled trial of the dual PPAR alpha-delta agonist GFT505 in adult patients with NASH." 66th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD). San Francisco, CA. November 13, 2015 - November 17, 2015.: WILEY-BLACKWELL, October 1, 2015. Link to Item
  - Ratziu, V, Sanyal, AJ, Loomba, R, Caldwell, SH, Ghalib, RH, Torres, DM, McCullough, AJ, Muir, AJ, Myers, RP, Schall, REA, Subramanian, M, McHutchison, JG, Bosch, J, Harrison, SA, and Abdelmalek, MF. "Characterization of insulin resistance in patients with advanced fibrosis due to nonalcoholic steatohepatitis (NASH)." October 2015. Link to Item
  - Sanyal, AJ, Goodman, ZD, Abdelmalek, MF, Harrison, SA, Rockey, DC, Diehl, AM, Caldwell, SH, Shiffman, ML, Myers, RP, Schall, REA, Subramanian, M, McHutchison, JG, Ratziu, V, Afdhal, NH, and Bosch, J. "Clinical and histologic correlates of the hepatic venous pressure gradient (HVPG) in patients with compensated cirrhosis due to nonalcoholic steatohepatitis (NASH)." October 2015. Link to Item
  - Sanyal, AJ, Harrison, SA, Francque, SM, Bedossa, P, Serfaty, L, Romero-Gomez, M, Cales, P, Abdelmalek, MF, Caldwell, SH, Drenth, J, Anstee, QM, Hum, DW, Hanf, R, Roudot, A, Megnien, S, Staels, B, and Ratziu, V. "The hepatic and extra-hepatic profile of resolution of steatohepatitis induced by GFT-505." October 2015. Link to Item
  - Vuppalanchi, R, Siddiqui, MS, Hallinan, EK, Abdelmalek, MF, Neuschwander-Tetri, BA, Loomba, R, Kowdley, KV, Terrault, N, McCullough, AJ, Tonascia, J, Brunt, EM, Kleiner, DE, Doo, E, Chalasani, NP, and Sanyal, AJ. "Transient Elastography is Feasible with High Success Rate for Evaluation of Non-Alcoholic Fatty Liver Disease (NAFLD) in a Multicenter Setting." October 2015. Link to Item
  - Zhu, R, Baker, SS, Moylan, CA, Abdelmalek, MF, Guy, CD, Zamboni, F, Wu, D, Lin, W, Liu, W, Baker, RD, Govindarajan, S, Cao, Z, Farci, P, Diehl, AM, and Zhu, L. "Systematic Analysis of NAFLD Transcriptome Revealed Elevated Expression of Alcohol Metabolizing Genes in Mild and Severe NAFLD Livers." April 2015. Link to Item
  - Kochhar, S, Abdelmalek, MF, Guy, CD, Piercy, D, Pan, Y, Diehl, AM, and Suzuki, A. "Associations of Sleep Duration and Sleep Quality With Clinical and Histologic Features of Nonalcoholic Fatty Liver Disease (NAFLD)." May 2014. Link to Item
  - Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Yates, KP, Unalp, A, Lavine, JE, Diehl, AM, and Suzuki, A. "Associations of Sex and Menopause With Histologic Severity of Necroinflammation and Portal Inflammation Among Patients With Nonalcoholic Fatty Liver Disease (NAFLD)." May 2014. Link to Item
  - Yang, JD, Abdelmalek, MF, Pang, H, Guy, CD, Smith, AD, Diehl, AM, and Suzuki, A. "Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis." April 2014. Full Text
  - Bohinc, B, Michelotti, GA, Xie, G, Pang, H, Suzuki, A, Guy, CD, Piercy, DL, Kruger, L, Swiderska-Syn, M, Machado, MV, Pereira, TA, Zavacki, AM, Abdelmalek, MF, and Diehl, AM. "Repair-related Activation of Hedgehog Signaling in Stromal Cells Promotes Intrahepatic Hypothyroidism." 2014. Link to Item
  - Deng, Y, Palmeri, ML, Rouze, NC, Rosenzweig, SJ, Abdelmalek, MF, and Nightingale, KR. "Analyzing the impact of increasing Mechanical Index (MI) and energy deposition on shear wave speed (SWS) reconstruction in human liver." January 1, 2014. Full Text
  - Klair, JS, Yang, JD, Abdelmalek, MF, Guy, CD, Gill, RM, Yates, KP, Unalp-Arida, A, Lavine, JE, Clark, JM, Diehl, AM, and Suzuki, A. "Risk of severe fibrosis is associated with age at menopause in nonalcoholic fatty liver disease (NAFLD)." 2014. Link to Item
  - Urban, TJ, Moylan, CA, Rein, M, Abdelmalek, MF, Goldstein, DB, and Diehl, AM. "Whole Exome Sequencing of Extreme Phenotypes of NAFLD Identifies Potential Genetic Risk Factors for Advanced Hepatic Fibrosis." 2014. Link to Item
  - Guy, CD, Suzuki, A, Abdelmalek, MF, Burchette, J, and Diehl, AM. "Hedgehog Pathway Targeted by Vitamin E Therapy in NASH." October 2013. Link to Item
  - Garrett, ME, Moylan, CA, Gibson, J, Yang, H, Pang, H, Dellinger, A, Suzuki, A, Tillmann, HL, Guy, CD, Abdelmalek, MF, Murphy, SK, Diehl, AM, Hauser, M, and Ashley-Koch, AE. "Expression QTL analysis of a gene expression signature which predicts advanced non-alcoholic fatty liver disease." October 2012. Link to Item
  - Suzuki, A, Guy, CD, Pang, H, Smith, AD, Diehl, AM, and Abdelmalek, MF. "Impact of Gender and Menopause on Histologic Severity of Inflammation and Injury in patients with Nonalcoholic Fatty Liver Disease." October 2012. Link to Item
  - Moylan, CA, Yang, H, Pang, H, Dellinger, A, Suzuki, A, Tillmann, HL, Guy, CD, Ashley-Koch, AE, Garrett, ME, Abdelmalek, MF, Hauser, MA, Murphy, SK, and Diehl, AM. "Epigenetic Regulation of Gene Expression in NAFLD." May 2012. Link to Item
  - Corbin, KD, Spencer, MD, da Costa, K-A, Sha, W, Abdelmalek, MF, Pan, Y, Suzuki, A, Guy, CD, Cardona, DM, Torquati, A, Diehl, AM, and Zeisel, SH. "Genotype-based hierarchical clustering reveals a panel of polymorphisms in one carbon metabolism that are associated with obesity." April 2012. Link to Item
  - Shah, KK, Suzuki, A, Schwimmer, JB, Unalp, A, Guy, CD, Molleston, JP, Whitington, PF, Johnson, R, Diehl, AM, and Abdelmalek, MF. "DOSE DEPENDENT ASSOCIATION OF FRUCTOSE CONSUMPTION WITH HYPERURICEMIA AND INSULIN RESISTANCE IN CHILDREN WITH NAFLD." October 2011. Link to Item
  - Moylan, CA, Dellinger, A, Pang, H, Suzuki, A, Tillmann, HL, Hampton, D, Chen, Y, Choi, SS, Hauser, MA, Abdelmalek, MF, and Diehl, AM. "Modest Alcohol Consumption Attenuates Expression of Fibrosis-Associated Genes in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD)." May 2011. Link to Item
  - Zdanowicz, M, Suzuki, A, Guy, CD, Schwimmer, J, Abdelmalek, MF, Lavine, JE, and Diehl, AM. "Hedgehog Pathway Activation is Associated With Advanced Fibrosis in Pediatric NAFLD." May 2011. Link to Item
  - Corbin, KD, da Costa, K-A, Sha, W, Abdelmalek, MF, Diehl, AM, and Zeisel, SH. "Single nucleotide polymorphisms affecting phosphatidylcholine transport are associated with obesity." April 2011. Link to Item
  - Abdelmalek, MF, Suzuki, A, Schmidt, S, Rimmler, J, Unalp, A, Guy, CD, Johnson, R, Hauser, MA, and Diehl, AM. "FRUCTOKINASE POLYMORPHISMS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE ARE ASSOCIATED WITH DECREASED URIC ACID AND THE PRESENCE OF HEPATIC FIBROSIS." October 2010. Link to Item
  - Moylan, CA, Abdelmalek, MF, Pang, H, Dellinger, A, Choi, SS, Omenetti, A, Chen, Y, Hampton, D, Syn, W-K, Suzuki, A, Tillmann, HL, Acharya, CR, Potti, A, Hauser, MA, and Diehl, AM. "SIGNALS FROM THE FIBROTIC LIVER IN PATIENTS WITH NAFLD MAY PROMOTE DIABETES AND OBESITY." October 2010. Link to Item
  - Moylan, CA, Choi, SS, Dellinger, A, Pang, H, Abdelmalek, MF, Hampton, D, Chen, Y, Omenetti, A, Suzuki, A, Tillmann, HL, Acharya, CR, Potti, A, Hauser, MA, and Diehl, AM. "CONSERVED GENE EXPRESSION PATTERNS IN MYOFIBROBLASTIC MURINE AND HUMAN HEPATIC STELLATE CELLS AND NAFLD PATIENTS WITH LIVER FIBROSIS COMPATIBLE WITH EPITHELIAL-TO-MESENCHYMAL LIKE TRANSITION." October 2010. Link to Item
  - Piercy, DL, Suzuki, A, Feng, J, Pan, Y, Guy, CD, Diehl, AM, Chiang, AA, and Abdelmalek, MF. "OBSTRUCTIVE SLEEP APNEA WORSENS HEPATIC INFLAMMATION AND FIBROSIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE." October 2010. Link to Item
  - Suzuki, A, Binks, M, Omenetti, A, Guy, CD, Pryor, AD, Pan, Y, Smith, MM, Diehl, AM, and Abdelmalek, MF. "DEPRESSION AND ANXIETY SCORES ARE INDEPENDENTLY ASSOCIATED WITH HISTOLOGIC SEVERITY IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE." October 2010. Link to Item
  - Abdelmalek, MF, Lazo, M, Bonekamp, S, Diehl, AM, and Clark, JM. "INCREASED DIETARY FRUCTOSE IMPAIRS HEPATIC ATP HOMEOSTASIS IN NAFLD." October 2009. Link to Item
  - Suzuki, A, Guy, CD, Smith, AD, DeMaria, EJ, Pan, Y, Smith, MM, Diehl, AM, and Abdelmalek, MF. "GENDER AND HORMONAL STATUS ARE ASSOCIATED WITH SEVERITY OF HISTOLOGIC FEATURES AMONG PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE." October 2009. Link to Item
  - Wang, M, Palmeri, M, Rouze, N, Rotemberg, V, Moser, B, Guy, CD, Diehl, AM, Abdelmalek, MF, and Nightingale, K. "NON-INVASIVE ASSESSMENT OF LIVER FIBROSIS WITH QUANTITATIVE ACOUSTIC RADIATION FORCE METHODS." October 2009. Link to Item
  - Suzuki, A, Abdelmalek, MF, Guy, CD, Schwimmer, J, Lavine, JE, Scheimann, AO, and Diehl, AM. "Sexual Development and Its Influence On Regional Anthropometric Measures and Histologic Features Among Pediatric Patients with NAFLD." May 2009. Link to Item
  - Abdelmalek, MF, Lindor, KD, Cave, MC, Falkner, KC, Khan, R, and McClain, CJ. "HIGH-DOSE BETAINE TREATMENT DOES NOT POSITIVELY INFLUENCE SECOND HIT MECHANISMS IN NASH." October 2008. Link to Item
  - Jung, Y, Guy, CD, Yang, L, Abdelmalek, MF, and Diehl, AM. "PROGRESSIVE HEDGEHOG PATHWAY ACTIVATION ACCOMPANIES THE DUCTULAR REACTION DURING NAFLD PROGRESSION IN MICE AND HUMANS." October 2008. Link to Item
  - Suzuki, A, Abdelmalek, MF, Guy, CD, and Diehl, AM. "GENDER-SPECIFIC ASSOCIATIONS BETWEEN REGIONAL ANTHROPOMETRIC MEASURES AND HEPATIC FIBROSIS IN PATIENTS WITH NAFLD." October 2008. Link to Item
  - Abdelmalek, MF, Sanderson, SO, Angulo, P, Liu, C, Peter, J, Keach, J, and Lindor, KD. "Betaine for treatment of nonalcoholic steatohepatitis: Results of a randomized placebo controlled study." October 2006. Link to Item
  - Abdelmalek, MF, Angulo, P, Jorgensen, RA, Sylvestre, PB, and Lindor, KD. "Betaine for the treatment of nonalcoholic steatohepatitis: A promising new agent." April 2000. Full Text Link to Item

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