Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Fellow in Gastroenterology, Medicine, Mayo School of Health Sciences 1995 - 1998
  • Medical Resident, Medicine, Mayo School of Health Sciences 1992 - 1995
  • M.D., University Missouri Kansas City 1992
• 

  Duke Appointment History

  • Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2014 - 2017
  • Associate Professor of Medicine, Medicine, Gastroenterology, Medicine 2006 - 2014
  • Instructor, Temporary in the Department of Medicine, Medicine, Gastroenterology, Medicine 2006
• Research
• 

  Selected Grants

  • Gilead 384-1943 2017 - 2025
  • Gilead 384-1944 2017 - 2025
  • Madrigal MGL-3196-11 2019 - 2024
  • Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) awarded by National Institutes of Health 2004 - 2024
  • ARMOR 2019 - 2023
  • Celgene CC-90001 NASH-001 2019 - 2023
  • NovoNordisk 4492 2019 - 2023
  • Duke CTSA (TL1) awarded by National Institutes of Health 2018 - 2023
  • Target-NASH 2017 - 2023
  • MEDI0382 2019 - 2022
  • Intercept 747-303 2015 - 2022
  • Genentech GC41003 2019 - 2022
  • Durect DUR-928 2019 - 2022
  • FALCON 1 2018 - 2022
  • FALCON 2 2018 - 2022
  • Inventiva IVA337 2019 - 2022
  • NGM282 18-0108 2019 - 2022
  • Genfit GFT505-315-1 NASH 2016 - 2022
  • STAMP - STudy of AMP Kinase Activator 2019 - 2021
  • Novartis LJC242A2201J 2018 - 2021
  • Intercept 747-304 2017 - 2021
  • Galectin GI-026 2015 - 2021
  • Enyo EYP001-202 2019 - 2021
  • Allergan 301-002 2017 - 2020
  • Allergan 201-002 2017 - 2020
  • Progenity PRO-121-NAFLD 2017 - 2020
  • Enanta EDP 305-101 2018 - 2020
  • Conatus IDN 6556-17 2017 - 2020
  • Gilead 454-4378 2018 - 2020
  • Boehringer BI 1467335 2017 - 2020
  • Genetic and Epigenetic Markers of Progressive Nonalcoholic Fatty Liver Disease awarded by American Association for the Study of Liver Diseases 2018 - 2020
  • Gilead 384-1497 2015 - 2020
  • Conatus IDN 6556-14 2016 - 2019
  • TOBIRA 652-2-203 2014 - 2019
  • Madrigal MGL-3196-05 2016 - 2019
  • Conatus IDN-6556-12 2015 - 2019
  • BMS MB130-045 2015 - 2019
  • NGM 15-0105 2015 - 2019
  • Immuron IMM-124E 2014 - 2019
  • Shire SHP626-201 2016 - 2019
  • Gilead 402-1852 2016 - 2019
  • GILEAD 426-3989 2016 - 2019
  • Intercept 747-117 2018 - 2019
  • ARREST - GALMED 2015 - 2019
  • Intercept 747-209 2015 - 2019
  • Cirius EMMINENCE 2017 - 2018
  • Exalenz - CSPH-EX-0414 2016 - 2018
  • Glympse Bio NASH 2017
  • Acoustic Radiation Force Based Hepatic Elasticity Quantification and Imaging awarded by National Institutes of Health 2001 - 2017
  • ARI-3037MO-006 2015 - 2017
  • Impact of Fructose on Metabolism, Energy Homeostasis and MR biomarkers in NAFLD awarded by National Institutes of Health 2012 - 2016
  • Synageva BioPharma LAL-CSS01 2014 - 2016
  • Development and clinical validation of a clinical diagnostic/prognostic laboratory test for liver disease 2014 - 2016
  • Characterizing Alcohol's Effects on Repair of Liver Injury awarded by National Institutes of Health 2009 - 2012
  • Hyperinsulimia and Insulin Resistance in Nonalcoholic Fatty Liver Disease awarded by National Institutes of Health 2006 - 2010
• 

  External Relationships

  • Alexion
  • Allergan
  • Bristol-Myers Squibb
  • Celgene Pharmaceuticals
  • Clinical Care Options
  • Durect
  • E.R. Squibb & Sons, LLC
  • Galmed
  • Genentech, Inc (Roche Holding)
  • Genfit
  • Intercept
  • Inventiva
  • Lexicon
  • Madrigal
  • NGM Biopharmaceuticals
  • Novo Nordisk
  • PanNASH Initiative
  • Pfizer Inc.
  • Poxel
  • Prime Education
  • Taiwan J Pharmaceuticals
  • iHEP NASH
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Du, Kuo, Satish K. Chitneni, Ayako Suzuki, Ying Wang, Ricardo Henao, Jeongeun Hyun, Richard T. Premont, et al. “Increased Glutaminolysis Marks Active Scarring in Nonalcoholic Steatohepatitis Progression.” Cell Mol Gastroenterol Hepatol, December 25, 2019. https://doi.org/10.1016/j.jcmgh.2019.12.006.
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    • Anstee, Quentin M., Brent A. Neuschwander-Tetri, Vincent Wai-Sun Wong, Manal F. Abdelmalek, Zobair M. Younossi, Jiacheng Yuan, Maria Lucia Pecoraro, et al. “Cenicriviroc for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis: AURORA Phase 3 study design.” Contemp Clin Trials 89 (December 24, 2019): 105922. https://doi.org/10.1016/j.cct.2019.105922.
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    • Sanyal, Arun, Edgar D. Charles, Brent A. Neuschwander-Tetri, Rohit Loomba, Stephen A. Harrison, Manal F. Abdelmalek, Eric J. Lawitz, et al. “Pegbelfermin (BMS-986036), a PEGylated fibroblast growth factor 21 analogue, in patients with non-alcoholic steatohepatitis: a randomised, double-blind, placebo-controlled, phase 2a trial.” Lancet 392, no. 10165 (December 22, 2019): 2705–17. https://doi.org/10.1016/S0140-6736(18)31785-9.
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    • Younossi, Zobair M., Vlad Ratziu, Rohit Loomba, Mary Rinella, Quentin M. Anstee, Zachary Goodman, Pierre Bedossa, et al. “Obeticholic acid for the treatment of non-alcoholic steatohepatitis: interim analysis from a multicentre, randomised, placebo-controlled phase 3 trial.” Lancet 394, no. 10215 (December 14, 2019): 2184–96. https://doi.org/10.1016/S0140-6736(19)33041-7.
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    • Win, Sanda, Robert Wm Min, Christopher Q. Chen, Jun Zhang, Yibu Chen, Meng Li, Ayako Suzuki, et al. “Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.” J Clin Invest 129, no. 12 (December 2, 2019): 5278–93. https://doi.org/10.1172/JCI128289.
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    • Samji, Naga Swetha, Rajanshu Verma, Krishna Chaitanya Keri, Ashwani K. Singal, Aijaz Ahmed, Mary Rinella, David Bernstein, Manal F. Abdelmalek, and Sanjaya K. Satapathy. “Liver Transplantation for Nonalcoholic Steatohepatitis: Pathophysiology of Recurrence and Clinical Challenges.” Dig Dis Sci 64, no. 12 (December 2019): 3413–30. https://doi.org/10.1007/s10620-019-05716-1.
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    • Sanyal, Arun J., Stephen A. Harrison, Vlad Ratziu, Manal F. Abdelmalek, Anna Mae Diehl, Stephen Caldwell, Mitchell L. Shiffman, et al. “The Natural History of Advanced Fibrosis Due to Nonalcoholic Steatohepatitis: Data From the Simtuzumab Trials.” Hepatology 70, no. 6 (December 2019): 1913–27. https://doi.org/10.1002/hep.30664.
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    • Rana, Rajashree, Andrew M. Shearer, Elizabeth K. Fletcher, Nga Nguyen, Srijoy Guha, Daniel H. Cox, Manal Abdelmalek, et al. “PAR2 controls cholesterol homeostasis and lipid metabolism in nonalcoholic fatty liver disease.” Mol Metab 29 (November 2019): 99–113. https://doi.org/10.1016/j.molmet.2019.08.019.
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    • Gawrieh, Samer, Laura A. Wilson, Oscar W. Cummings, Jeanne M. Clark, Rohit Loomba, Bilal Hameed, Manal F. Abdelmalek, et al. “Histologic Findings of Advanced Fibrosis and Cirrhosis in Patients With Nonalcoholic Fatty Liver Disease Who Have Normal Aminotransferase Levels.” Am J Gastroenterol 114, no. 10 (October 2019): 1626–35. https://doi.org/10.14309/ajg.0000000000000388.
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    • Lonardo, Amedeo, Fabio Nascimbeni, Stefano Ballestri, DeLisa Fairweather, Sanda Win, Tin A. Than, Manal F. Abdelmalek, and Ayako Suzuki. “Sex Differences in Nonalcoholic Fatty Liver Disease: State of the Art and Identification of Research Gaps.” Hepatology 70, no. 4 (October 2019): 1457–69. https://doi.org/10.1002/hep.30626.
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    • Rinella, Mary E., Frank Tacke, Arun J. Sanyal, Quentin M. Anstee, and Quentin M. participants of the AASLD/EASL Workshop. “Report on the AASLD/EASL Joint Workshop on Clinical Trial Endpoints in NAFLD.” Hepatology 70, no. 4 (October 2019): 1424–36. https://doi.org/10.1002/hep.30782.
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    • Rinella, Mary E., Frank Tacke, Arun J. Sanyal, Quentin M. Anstee, and Quentin M. participants of the AASLD/EASL Workshop. “Report on the AASLD/EASL joint workshop on clinical trial endpoints in NAFLD.” J Hepatol 71, no. 4 (October 2019): 823–33. https://doi.org/10.1016/j.jhep.2019.04.019.
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    • Loomba, Rohit, Anjali Jain, Anna Mae Diehl, Cynthia D. Guy, Dana Portenier, Ranjan Sudan, Seema Singh, et al. “Validation of Serum Test for Advanced Liver Fibrosis in Patients With Nonalcoholic Steatohepatitis.” Clin Gastroenterol Hepatol 17, no. 9 (August 2019): 1867-1876.e3. https://doi.org/10.1016/j.cgh.2018.11.004.
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    • Siddiqui, Mohammad Shadab, Goro Yamada, Raj Vuppalanchi, Mark Van Natta, Rohit Loomba, Cynthia Guy, Danielle Brandman, et al. “Diagnostic Accuracy of Noninvasive Fibrosis Models to Detect Change in Fibrosis Stage.” Clin Gastroenterol Hepatol 17, no. 9 (August 2019): 1877-1885.e5. https://doi.org/10.1016/j.cgh.2018.12.031.
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    • Chalasani, Naga, Manal F. Abdelmalek, Rohit Loomba, Kris V. Kowdley, Arthur J. McCullough, Srinivasan Dasarathy, Brent A. Neuschwander-Tetri, et al. “Relationship between three commonly used non-invasive fibrosis biomarkers and improvement in fibrosis stage in patients with non-alcoholic steatohepatitis.” Liver Int 39, no. 5 (May 2019): 924–32. https://doi.org/10.1111/liv.13974.
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    • Corey, Kathleen E., Laura A. Wilson, Akif Altinbas, Katherine P. Yates, David E. Kleiner, Raymond T. Chung, Ronald M. Krauss, Naga Chalasani, and Naga NASH Clinical Research Network. “Relationship between resolution of non-alcoholic steatohepatitis and changes in lipoprotein sub-fractions: a post-hoc analysis of the PIVENS trial.” Aliment Pharmacol Ther 49, no. 9 (May 2019): 1205–13. https://doi.org/10.1111/apt.15216.
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    • Rinella, Mary E., James F. Trotter, Manal F. Abdelmalek, Angelo H. Paredes, Margery A. Connelly, Mark J. Jaros, Lei Ling, Stephen J. Rossi, Alex M. DePaoli, and Stephen A. Harrison. “Rosuvastatin improves the FGF19 analogue NGM282-associated lipid changes in patients with non-alcoholic steatohepatitis.” J Hepatol 70, no. 4 (April 2019): 735–44. https://doi.org/10.1016/j.jhep.2018.11.032.
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    • Jayakumar, Saumya, Michael S. Middleton, Eric J. Lawitz, Parvez S. Mantry, Stephen H. Caldwell, Hays Arnold, Anna Mae Diehl, et al. “Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonsertib.” J Hepatol 70, no. 1 (January 2019): 133–41. https://doi.org/10.1016/j.jhep.2018.09.024.
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    • Loomba, Rohit, Arun J. Sanyal, Kris V. Kowdley, Norah Terrault, Naga P. Chalasani, Manal F. Abdelmalek, Arthur J. McCullough, et al. “Factors Associated With Histologic Response in Adult Patients With Nonalcoholic Steatohepatitis.” Gastroenterology 156, no. 1 (January 2019): 88-95.e5. https://doi.org/10.1053/j.gastro.2018.09.021.
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    • Siddiqui, Mohammad S., Raj Vuppalanchi, Mark L. Van Natta, Erin Hallinan, Kris V. Kowdley, Manal Abdelmalek, Brent A. Neuschwander-Tetri, et al. “Vibration-Controlled Transient Elastography to Assess Fibrosis and Steatosis in Patients With Nonalcoholic Fatty Liver Disease.” Clin Gastroenterol Hepatol 17, no. 1 (January 2019): 156-163.e2. https://doi.org/10.1016/j.cgh.2018.04.043.
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    • Younossi, Zobair, Maria Stepanova, Arun J. Sanyal, Stephen A. Harrison, Vlad Ratziu, Manal F. Abdelmalek, Anna Mae Diehl, et al. “The conundrum of cryptogenic cirrhosis: Adverse outcomes without treatment options.” J Hepatol 69, no. 6 (December 2018): 1365–70. https://doi.org/10.1016/j.jhep.2018.08.013.
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    • Glass, Oliver, Ricardo Henao, Keyur Patel, Cynthia D. Guy, Hans J. Gruss, Wing-Kin Syn, Cynthia A. Moylan, et al. “Serum Interleukin-8, Osteopontin, and Monocyte Chemoattractant Protein 1 Are Associated With Hepatic Fibrosis in Patients With Nonalcoholic Fatty Liver Disease.” Hepatol Commun 2, no. 11 (November 2018): 1344–55. https://doi.org/10.1002/hep4.1237.
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    • Wildman-Tobriner, Benjamin, Michael M. Middleton, Cynthia A. Moylan, Stephen Rossi, Omar Flores, Zac Anchi Chang, Manal F. Abdelmalek, Claude B. Sirlin, and Mustafa R. Bashir. “Association Between Magnetic Resonance Imaging-Proton Density Fat Fraction and Liver Histology Features in Patients With Nonalcoholic Fatty Liver Disease or Nonalcoholic Steatohepatitis.” Gastroenterology 155, no. 5 (November 2018): 1428-1435.e2. https://doi.org/10.1053/j.gastro.2018.07.018.
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    • Harrison, Stephen A., Manal F. Abdelmalek, Stephen Caldwell, Mitchell L. Shiffman, Anna Mae Diehl, Reem Ghalib, Eric J. Lawitz, et al. “Simtuzumab Is Ineffective for Patients With Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis.” Gastroenterology 155, no. 4 (October 2018): 1140–53. https://doi.org/10.1053/j.gastro.2018.07.006.
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    • Moylan, Cynthia A., and Manal F. Abdelmalek. “Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis.” Hepatology 68, no. 4 (October 2018): 1646–48. https://doi.org/10.1002/hep.29879.
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    • Yang, Ju Dong, Manal F. Abdelmalek, Cynthia D. Guy, Anna Mae Diehl, and Ayako Suzuki. “Reply.” Clin Gastroenterol Hepatol 16, no. 10 (October 2018): 1684. https://doi.org/10.1016/j.cgh.2017.05.003.
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    • Kleinstein, Sarah E., Matthew Rein, Manal F. Abdelmalek, Cynthia D. Guy, David B. Goldstein, Anna Mae Diehl, and Cynthia A. Moylan. “Whole-Exome Sequencing Study of Extreme Phenotypes of NAFLD.” Hepatol Commun 2, no. 9 (September 2018): 1021–29. https://doi.org/10.1002/hep4.1227.
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    • Younossi, Zobair M., Rohit Loomba, Mary E. Rinella, Elisabetta Bugianesi, Giulio Marchesini, Brent A. Neuschwander-Tetri, Lawrence Serfaty, et al. “Current and future therapeutic regimens for nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.” Hepatology 68, no. 1 (July 2018): 361–71. https://doi.org/10.1002/hep.29724.
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    • Younossi, Zobair M., Rohit Loomba, Quentin M. Anstee, Mary E. Rinella, Elisabetta Bugianesi, Giulio Marchesini, Brent A. Neuschwander-Tetri, et al. “Diagnostic modalities for nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, and associated fibrosis.” Hepatology 68, no. 1 (July 2018): 349–60. https://doi.org/10.1002/hep.29721.
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    • Friedman, Scott L., Vlad Ratziu, Stephen A. Harrison, Manal F. Abdelmalek, Guruprasad P. Aithal, Juan Caballeria, Sven Francque, et al. “A randomized, placebo-controlled trial of cenicriviroc for treatment of nonalcoholic steatohepatitis with fibrosis.” Hepatology 67, no. 5 (May 2018): 1754–67. https://doi.org/10.1002/hep.29477.
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    • Jensen, Thomas, Manal F. Abdelmalek, Shelby Sullivan, Kristen J. Nadeau, Melanie Green, Carlos Roncal, Takahiko Nakagawa, et al. “Fructose and sugar: A major mediator of non-alcoholic fatty liver disease.” J Hepatol 68, no. 5 (May 2018): 1063–75. https://doi.org/10.1016/j.jhep.2018.01.019.
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    • Siddiqui, Mohammad Shadab, Stephen A. Harrison, Manal F. Abdelmalek, Quentin M. Anstee, Pierre Bedossa, Laurent Castera, Lara Dimick-Santos, et al. “Case definitions for inclusion and analysis of endpoints in clinical trials for nonalcoholic steatohepatitis through the lens of regulatory science.” Hepatology 67, no. 5 (May 2018): 2001–12. https://doi.org/10.1002/hep.29607.
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    • Harrison, Stephen A., Mary E. Rinella, Manal F. Abdelmalek, James F. Trotter, Angelo H. Paredes, Hays L. Arnold, Marcelo Kugelmas, et al. “NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.” Lancet 391, no. 10126 (March 24, 2018): 1174–85. https://doi.org/10.1016/S0140-6736(18)30474-4.
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    • Vuppalanchi, Raj, Mohammad S. Siddiqui, Mark L. Van Natta, Erin Hallinan, Danielle Brandman, Kris Kowdley, Brent A. Neuschwander-Tetri, et al. “Performance characteristics of vibration-controlled transient elastography for evaluation of nonalcoholic fatty liver disease.” Hepatology 67, no. 1 (January 2018): 134–44. https://doi.org/10.1002/hep.29489.
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    • Wegermann, Kara, Ricardo Henao, Anna Mae Diehl, Susan K. Murphy, Manal F. Abdelmalek, and Cynthia A. Moylan. “Branched chain amino acid transaminase 1 (BCAT1) is overexpressed and hypomethylated in patients with non-alcoholic fatty liver disease who experience adverse clinical events: A pilot study.” Plos One 13, no. 9 (2018): e0204308. https://doi.org/10.1371/journal.pone.0204308.
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    • Glass, O. K., A. Radia, W. E. Kraus, and M. F. Abdelmalek. “Exercise training as treatment of nonalcoholic fatty liver disease.” Journal of Functional Morphology and Kinesiology 2, no. 4 (December 1, 2017). https://doi.org/10.3390/jfmk2040035.
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    • Newton, Kimberly P., Haruna S. Feldman, Christina D. Chambers, Laura Wilson, Cynthia Behling, Jeanne M. Clark, Jean P. Molleston, et al. “Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children.” J Pediatr 187 (August 2017): 141-146.e1. https://doi.org/10.1016/j.jpeds.2017.03.007.
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    • Kappus, Matthew, and Manal Abdelmalek. “De Novo and Recurrence of Nonalcoholic Steatohepatitis After Liver Transplantation.” Clin Liver Dis 21, no. 2 (May 2017): 321–35. https://doi.org/10.1016/j.cld.2016.12.006.
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    • Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Reply to Kim et al.” Am J Gastroenterol 112, no. 5 (May 2017): 807–8. https://doi.org/10.1038/ajg.2017.45.
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    • Yang, Ju Dong, Manal F. Abdelmalek, Cynthia D. Guy, Ryan M. Gill, Joel E. Lavine, Katherine Yates, Jagpal Klair, et al. “Patient Sex, Reproductive Status, and Synthetic Hormone Use Associate With Histologic Severity of Nonalcoholic Steatohepatitis.” Clin Gastroenterol Hepatol 15, no. 1 (January 2017): 127-131.e2. https://doi.org/10.1016/j.cgh.2016.07.034.
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    • Abdelmalek, Manal F. “NAFLD: The clinical and economic burden of NAFLD: time to turn the tide.” Nat Rev Gastroenterol Hepatol 13, no. 12 (December 2016): 685–86. https://doi.org/10.1038/nrgastro.2016.178.
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    • Nelson, J. E., P. Handa, B. Aouizerat, L. Wilson, L. A. Vemulakonda, M. M. Yeh, K. V. Kowdley, and K. V. NASH Clinical Research Network. “Increased parenchymal damage and steatohepatitis in Caucasian non-alcoholic fatty liver disease patients with common IL1B and IL6 polymorphisms.” Aliment Pharmacol Ther 44, no. 11–12 (December 2016): 1253–64. https://doi.org/10.1111/apt.13824.
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    • Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Vitamin D is Not Associated With Severity in NAFLD: Results of a Paired Clinical and Gene Expression Profile Analysis.” Am J Gastroenterol 111, no. 11 (November 2016): 1591–98. https://doi.org/10.1038/ajg.2016.406.
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    • Klair, Jagpal Singh, Ju Dong Yang, Manal F. Abdelmalek, Cynthia D. Guy, Ryan M. Gill, Katherine Yates, Aynur Unalp-Arida, et al. “A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease.” Hepatology 64, no. 1 (July 2016): 85–91. https://doi.org/10.1002/hep.28514.
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    • Ratziu, Vlad, Stephen A. Harrison, Sven Francque, Pierre Bedossa, Philippe Lehert, Lawrence Serfaty, Manuel Romero-Gomez, et al. “Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening.” Gastroenterology 150, no. 5 (May 2016): 1147-1159.e5. https://doi.org/10.1053/j.gastro.2016.01.038.
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    • Thrasher, Tyler, and Manal F. Abdelmalek. “Nonalcoholic Fatty Liver Disease.” N C Med J 77, no. 3 (May 2016): 216–19. https://doi.org/10.18043/ncm.77.3.216.
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    • Zhu, Ruixin, Susan S. Baker, Cynthia A. Moylan, Manal F. Abdelmalek, Cynthia D. Guy, Fausto Zamboni, Dingfeng Wu, et al. “Systematic transcriptome analysis reveals elevated expression of alcohol-metabolizing genes in NAFLD livers.” J Pathol 238, no. 4 (March 2016): 531–42. https://doi.org/10.1002/path.4650.
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    • Abdelmalek, Manal F., and Chris Day. “Sugar sweetened beverages and fatty liver disease: Rising concern and call to action.” J Hepatol 63, no. 2 (August 2015): 306–8. https://doi.org/10.1016/j.jhep.2015.05.021.
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    • Deng, Yufeng, Mark L. Palmeri, Ned C. Rouze, Stephen J. Rosenzweig, Manal F. Abdelmalek, and Kathryn R. Nightingale. “Analyzing the Impact of Increasing Mechanical Index and Energy Deposition on Shear Wave Speed Reconstruction in Human Liver.” Ultrasound Med Biol 41, no. 7 (July 2015): 1948–57. https://doi.org/10.1016/j.ultrasmedbio.2015.02.019.
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    • Guy, Cynthia, Ayako Suzuki, Manal Abdelmalek, James Burchette, and Anna Mae Diehl. “Reply: To PMID 24849310.” Hepatology 61, no. 5 (May 2015): 1770–71. https://doi.org/10.1002/hep.27430.
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    • Neuschwander-Tetri, Brent A., Rohit Loomba, Arun J. Sanyal, Joel E. Lavine, Mark L. Van Natta, Manal F. Abdelmalek, Naga Chalasani, et al. “Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial.” Lancet 385, no. 9972 (March 14, 2015): 956–65. https://doi.org/10.1016/S0140-6736(14)61933-4.
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    • Guy, Cynthia D., Ayako Suzuki, Manal F. Abdelmalek, James L. Burchette, Anna Mae Diehl, and Anna Mae NASH CRN. “Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity.” Hepatology 61, no. 1 (January 2015): 98–107. https://doi.org/10.1002/hep.27235.
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    • Nightingale, Kathryn R., Ned C. Rouze, Stephen J. Rosenzweig, Michael H. Wang, Manal F. Abdelmalek, Cynthia D. Guy, and Mark L. Palmeri. “Derivation and analysis of viscoelastic properties in human liver: impact of frequency on fibrosis and steatosis staging.” Ieee Trans Ultrason Ferroelectr Freq Control 62, no. 1 (January 2015): 165–75. https://doi.org/10.1109/TUFFC.2014.006653.
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    • Bohinc, Brittany N., Gregory Michelotti, Guanhua Xie, Herbert Pang, Ayako Suzuki, Cynthia D. Guy, Dawn Piercy, et al. “Repair-related activation of hedgehog signaling in stromal cells promotes intrahepatic hypothyroidism.” Endocrinology 155, no. 11 (November 2014): 4591–4601. https://doi.org/10.1210/en.2014-1302.
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    • Sanyal, Arun J., Manal F. Abdelmalek, Ayako Suzuki, Oscar W. Cummings, Mario Chojkier, and Mario EPE-A Study Group. “No significant effects of ethyl-eicosapentanoic acid on histologic features of nonalcoholic steatohepatitis in a phase 2 trial.” Gastroenterology 147, no. 2 (August 2014): 377-84.e1. https://doi.org/10.1053/j.gastro.2014.04.046.
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    • Siddique, Asma, James E. Nelson, Bradley Aouizerat, Matthew M. Yeh, Kris V. Kowdley, and Kris V. NASH Clinical Research Network. “Iron deficiency in patients with nonalcoholic Fatty liver disease is associated with obesity, female gender, and low serum hepcidin.” Clin Gastroenterol Hepatol 12, no. 7 (July 2014): 1170–78. https://doi.org/10.1016/j.cgh.2013.11.017.
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    • Gadd, Victoria L., Richard Skoien, Elizabeth E. Powell, Kevin J. Fagan, Clay Winterford, Leigh Horsfall, Katharine Irvine, and Andrew D. Clouston. “The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease.” Hepatology 59, no. 4 (April 2014): 1393–1405. https://doi.org/10.1002/hep.26937.
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    • Moylan, Cynthia A., Herbert Pang, Andrew Dellinger, Ayako Suzuki, Melanie E. Garrett, Cynthia D. Guy, Susan K. Murphy, et al. “Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease.” Hepatology 59, no. 2 (February 2014): 471–82. https://doi.org/10.1002/hep.26661.
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    • Sanyal, Arun J., Manal F. Abdelmalek, Ayako Suzuki, Oscar Cummings, and Mario Chojkier. “A Phase 2B Double-Blind Placebo Controlled Study of Two Doses of EPA-E in Patients With Nonalcoholic Steatohepatitis.” Hepatology 58, no. 6 (December 1, 2013): 1385A-1385A.
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    • Ishimoto, Takuji, Miguel A. Lanaspa, Christopher J. Rivard, Carlos A. Roncal-Jimenez, David J. Orlicky, Christina Cicerchi, Rachel H. McMahan, et al. “High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase.” Hepatology 58, no. 5 (November 2013): 1632–43. https://doi.org/10.1002/hep.26594.
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    • Murphy, Susan K., Hyuna Yang, Cynthia A. Moylan, Herbert Pang, Andrew Dellinger, Manal F. Abdelmalek, Melanie E. Garrett, et al. “Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease.” Gastroenterology 145, no. 5 (November 2013): 1076–87. https://doi.org/10.1053/j.gastro.2013.07.047.
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    • Youssef, Nagy A., Manal F. Abdelmalek, Martin Binks, Cynthia D. Guy, Alessia Omenetti, Alastair D. Smith, Anna Mae E. Diehl, and Ayako Suzuki. “Associations of depression, anxiety and antidepressants with histological severity of nonalcoholic fatty liver disease.” Liver Int 33, no. 7 (August 2013): 1062–70. https://doi.org/10.1111/liv.12165.
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    • Swiderska-Syn, Marzena, Ayako Suzuki, Cynthia D. Guy, Jeffrey B. Schwimmer, Manal F. Abdelmalek, Joel E. Lavine, and Anna Mae Diehl. “Hedgehog pathway and pediatric nonalcoholic fatty liver disease.” Hepatology 57, no. 5 (May 2013): 1814–25. https://doi.org/10.1002/hep.26230.
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    • Corbin, Karen D., Manal F. Abdelmalek, Melanie D. Spencer, Kerry-Ann da Costa, Joseph A. Galanko, Wei Sha, Ayako Suzuki, et al. “Genetic signatures in choline and 1-carbon metabolism are associated with the severity of hepatic steatosis.” Faseb J 27, no. 4 (April 2013): 1674–89. https://doi.org/10.1096/fj.12-219097.
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    • Garrett, Melanie E., Manal F. Abdelmalek, Allison Ashley-Koch, Michael A. Hauser, Cynthia A. Moylan, Herbert Pang, Anna Mae Diehl, and Hans L. Tillmann. “IL28B rs12979860 is not associated with histologic features of NAFLD in a cohort of Caucasian North American patients.” J Hepatol 58, no. 2 (February 2013): 402–3. https://doi.org/10.1016/j.jhep.2012.09.035.
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    • Nelson, James E., Elizabeth M. Brunt, Kris V. Kowdley, and Kris V. Nonalcoholic Steatohepatitis Clinical Research Network. “Lower serum hepcidin and greater parenchymal iron in nonalcoholic fatty liver disease patients with C282Y HFE mutations.” Hepatology 56, no. 5 (November 2012): 1730–40. https://doi.org/10.1002/hep.25856.
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    • Abdelmalek, Manal F., Mariana Lazo, Alena Horska, Susanne Bonekamp, Edward W. Lipkin, Ashok Balasubramanyam, John P. Bantle, et al. “Higher dietary fructose is associated with impaired hepatic adenosine triphosphate homeostasis in obese individuals with type 2 diabetes.” Hepatology 56, no. 3 (September 2012): 952–60. https://doi.org/10.1002/hep.25741.
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    • Syn, Wing-Kin, Kolade M. Agboola, Marzena Swiderska, Gregory A. Michelotti, Evaggelia Liaskou, Herbert Pang, Guanhua Xie, et al. “NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease.” Gut 61, no. 9 (September 2012): 1323–29. https://doi.org/10.1136/gutjnl-2011-301857.
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    • Suzuki, Ayako, Manal F. Abdelmalek, Jeffrey B. Schwimmer, Joel E. Lavine, Ann O. Scheimann, Aynur Unalp-Arida, Katherine P. Yates, et al. “Association between puberty and features of nonalcoholic fatty liver disease.” Clin Gastroenterol Hepatol 10, no. 7 (July 2012): 786–94. https://doi.org/10.1016/j.cgh.2012.01.020.
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    • Guy, Cynthia D., Ayako Suzuki, James L. Burchette, Elizabeth M. Brunt, Manal F. Abdelmalek, Diana Cardona, Shannon J. McCall, et al. “Costaining for keratins 8/18 plus ubiquitin improves detection of hepatocyte injury in nonalcoholic fatty liver disease.” Hum Pathol 43, no. 6 (June 2012): 790–800. https://doi.org/10.1016/j.humpath.2011.07.007.
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    • Guy, Cynthia D., Ayako Suzuki, Marzena Zdanowicz, Manal F. Abdelmalek, James Burchette, Aynur Unalp, Anna Mae Diehl, and Anna Mae NASH CRN. “Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease.” Hepatology 55, no. 6 (June 2012): 1711–21. https://doi.org/10.1002/hep.25559.
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    • Corbin, Karen D., Melanie D. Spencer, Kerry-Ann da Costa, Wei Sha, Manal F. Abdelmalek, Yiping Pan, Ayako Suzuki, et al. “Genotype-based hierarchical clustering reveals a panel of polymorphisms in one carbon metabolism that are associated with obesity.” Faseb Journal 26 (April 1, 2012).
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    • Palmeri, M. L., M. F. Abdelmalek, and K. R. Nightingale. “Reply to: The use of acoustic radiation force-based shear stiffness in non-alcoholic fatty liver disease.” Journal of Hepatology 56, no. 4 (April 1, 2012). https://doi.org/10.1016/j.jhep.2011.09.007.
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    • Abdelmalek, M. F., A. Humar, F. Stickel, P. Andreone, A. Pascher, E. Barroso, G. W. Neff, et al. “Sirolimus conversion regimen versus continued calcineurin inhibitors in liver allograft recipients: a randomized trial.” Am J Transplant 12, no. 3 (March 2012): 694–705. https://doi.org/10.1111/j.1600-6143.2011.03919.x.
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    • Ratziu, Vlad, Muhammad Y. Sheikh, Arun J. Sanyal, Joseph K. Lim, Hari Conjeevaram, Naga Chalasani, Manal Abdelmalek, et al. “A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis.” Hepatology 55, no. 2 (February 2012): 419–28. https://doi.org/10.1002/hep.24747.
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    • Vos, Miriam B., Ryan Colvin, Patricia Belt, Jean P. Molleston, Karen F. Murray, Philip Rosenthal, Jeffrey B. Schwimmer, et al. “Correlation of vitamin E, uric acid, and diet composition with histologic features of pediatric NAFLD.” J Pediatr Gastroenterol Nutr 54, no. 1 (January 2012): 90–96. https://doi.org/10.1097/MPG.0b013e318229da1a.
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    • Palmeri, Mark L., Michael H. Wang, Ned C. Rouze, Manal F. Abdelmalek, Cynthia D. Guy, Barry Moser, Anna Mae Diehl, and Kathryn R. Nightingale. “Noninvasive evaluation of hepatic fibrosis using acoustic radiation force-based shear stiffness in patients with nonalcoholic fatty liver disease.” J Hepatol 55, no. 3 (September 2011): 666–72. https://doi.org/10.1016/j.jhep.2010.12.019.
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    • Rangwala, Fatima, Cynthia D. Guy, Jiuyi Lu, Ayako Suzuki, James L. Burchette, Manal F. Abdelmalek, Wei Chen, and Anna Mae Diehl. “Increased production of sonic hedgehog by ballooned hepatocytes.” J Pathol 224, no. 3 (July 2011): 401–10. https://doi.org/10.1002/path.2888.
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    • Speliotes, Elizabeth K., Laura M. Yerges-Armstrong, Jun Wu, Ruben Hernaez, Lauren J. Kim, Cameron D. Palmer, Vilmundur Gudnason, et al. “Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.” Plos Genet 7, no. 3 (March 2011): e1001324. https://doi.org/10.1371/journal.pgen.1001324.
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    • Syn, Wing-Kin, Steve S. Choi, Evaggelia Liaskou, Gamze F. Karaca, Kolade M. Agboola, Ye Htun Oo, Zhiyong Mi, et al. “Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.” Hepatology 53, no. 1 (January 2011): 106–15. https://doi.org/10.1002/hep.23998.
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    • Suzuki, Ayako, Manal F. Abdelmalek, Aynur Unalp-Arida, Katherine Yates, Arun Sanyal, Cynthia Guy, and Anna Mae Diehl. “Regional anthropometric measures and hepatic fibrosis in patients with nonalcoholic Fatty liver disease.” Clin Gastroenterol Hepatol 8, no. 12 (December 2010): 1062–69. https://doi.org/10.1016/j.cgh.2010.08.005.
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    • Abdelmalek, Manal F., Ayako Suzuki, Cynthia Guy, Aynur Unalp-Arida, Ryan Colvin, Richard J. Johnson, Anna Mae Diehl, and Anna Mae Nonalcoholic Steatohepatitis Clinical Research Network. “Increased fructose consumption is associated with fibrosis severity in patients with nonalcoholic fatty liver disease.” Hepatology 51, no. 6 (June 2010): 1961–71. https://doi.org/10.1002/hep.23535.
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    • Levene, Adam P., Hiromi Kudo, Mark R. Thursz, Quentin M. Anstee, and Robert D. Goldin. “Is oil red-O staining and digital image analysis the gold standard for quantifying steatosis in the liver?” Hepatology 51, no. 5 (May 2010): 1859. https://doi.org/10.1002/hep.23551.
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    • Sánchez-Lozada, Laura G., Wei Mu, Carlos Roncal, Yuri Y. Sautin, Manal Abdelmalek, Sirirat Reungjui, MyPhuong Le, et al. “Comparison of free fructose and glucose to sucrose in the ability to cause fatty liver.” Eur J Nutr 49, no. 1 (February 2010): 1–9. https://doi.org/10.1007/s00394-009-0042-x.
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    • Lavine, Joel E., Jeffrey B. Schwimmer, Jean P. Molleston, Ann O. Scheimann, Karen F. Murray, Stephanie H. Abrams, Philip Rosenthal, et al. “Treatment of nonalcoholic fatty liver disease in children: TONIC trial design.” Contemp Clin Trials 31, no. 1 (January 2010): 62–70. https://doi.org/10.1016/j.cct.2009.09.001.
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    • Abdelmalek, Manal F., Schuyler O. Sanderson, Paul Angulo, Consuelo Soldevila-Pico, Chen Liu, Joy Peter, Jill Keach, et al. “Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial.” Hepatology 50, no. 6 (December 2009): 1818–26. https://doi.org/10.1002/hep.23239.
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    • Shah, Amy G., Alison Lydecker, Karen Murray, Brent N. Tetri, Melissa J. Contos, Arun J. Sanyal, and Arun J. Nash Clinical Research Network. “Comparison of noninvasive markers of fibrosis in patients with nonalcoholic fatty liver disease.” Clin Gastroenterol Hepatol 7, no. 10 (October 2009): 1104–12. https://doi.org/10.1016/j.cgh.2009.05.033.
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    • Syn, Wing-Kin, Youngmi Jung, Alessia Omenetti, Manal Abdelmalek, Cynthia D. Guy, Liu Yang, Jiangbo Wang, et al. “Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.” Gastroenterology 137, no. 4 (October 2009): 1478-1488.e8. https://doi.org/10.1053/j.gastro.2009.06.051.
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    • Brunt, Elizabeth M., David E. Kleiner, Laura A. Wilson, Aynur Unalp, Cynthia E. Behling, Joel E. Lavine, Brent A. Neuschwander-Tetri, and Brent A. NASH Clinical Research NetworkA list of members of the Nonalcoholic Steatohepatitis Clinical Research Network can be found in the Appendix. “Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network.” Hepatology 49, no. 3 (March 2009): 809–20. https://doi.org/10.1002/hep.22724.
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    • Suzuki, Ayako, and Manal F. Abdelmalek. “Nonalcoholic fatty liver disease in women.” Womens Health (Lond) 5, no. 2 (March 2009): 191–203. https://doi.org/10.2217/17455057.5.2.191.
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    • Ouyang, Xiaosen, Pietro Cirillo, Yuri Sautin, Shannon McCall, James L. Bruchette, Anna Mae Diehl, Richard J. Johnson, and Manal F. Abdelmalek. “Fructose consumption as a risk factor for non-alcoholic fatty liver disease.” J Hepatol 48, no. 6 (June 2008): 993–99. https://doi.org/10.1016/j.jhep.2008.02.011.
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    • Palmeri, M. L., M. H. Wang, K. D. Frinkley, K. R. Nightingale, M. F. Abdelmalek, and A. M. Diehl. “Dependence of in vivo, radiation force derived hepatic shear modulus estimates on imaging approach: Intercostal vs. subcostal.” Proceedings  Ieee Ultrasonics Symposium, December 1, 2007, 566–69. https://doi.org/10.1109/ULTSYM.2007.147.
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    • Abdelmalek, Manal F., and Anna Mae Diehl. “Nonalcoholic fatty liver disease as a complication of insulin resistance.” Med Clin North Am 91, no. 6 (November 2007): 1125–ix. https://doi.org/10.1016/j.mcna.2007.06.001.
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    • Purohit, Vishnudutt, Manal F. Abdelmalek, Shirish Barve, Norlin J. Benevenga, Charles H. Halsted, Neil Kaplowitz, Kusum K. Kharbanda, et al. “Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium.” Am J Clin Nutr 86, no. 1 (July 2007): 14–24. https://doi.org/10.1093/ajcn/86.1.14.
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    • Abdelmalek, Manal F., Chen Liu, and John F. Valentine. “Successful treatment of chronic hepatitis C with pegylated interferon, ribavirin, and infliximab in a patient with Crohn's disease.” Am J Gastroenterol 102, no. 6 (June 2007): 1333–34. https://doi.org/10.1111/j.1572-0241.2007.01131.x.
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    • Abdelmalek, Manal F., and Anna Mae Diehl. “De novo nonalcoholic fatty liver disease after liver transplantation.” Liver Transpl 13, no. 6 (June 2007): 788–90. https://doi.org/10.1002/lt.21103.
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    • Abdelmalek, Manal F., Lane B. Hellner, Marc Zumberg, Victor W. Melgen, and Richard Lottenberg. “Acute liver failure occurring immediately following anti-D immune globulin infusion in a patient with chronic hepatitis B infection.” Dig Dis Sci 52, no. 4 (April 2007): 914–19. https://doi.org/10.1007/s10620-006-9319-6.
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    • Galhenage, Sumedha, Keyur Patel, Heathet M. Patton, Terry Walker, William Symonds, Manal F. Abdelmalek, and John G. Mchutchison. “The association of adipokine levels with changes in steatosis following treatment in patients with chronic hepatitis C infection.” Gastroenterology 132, no. 4 (April 1, 2007): A783–A783.
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    • Galhenage, S., and M. F. Abdelmalek. “The impact of steatosis and alcohol on hepatitis C.” Current Hepatitis Reports 6, no. 2 (January 1, 2007): 39–45. https://doi.org/10.1007/s11901-007-0002-y.
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    • Abdelmalek, M. F., and A. M. Diehl. “Mechanisms underlying nonalcoholic steatohepatitis.” Drug Discovery Today: Disease Mechanisms 3, no. 4 (December 1, 2006): 479–88. https://doi.org/10.1016/j.ddmec.2006.11.001.
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    • Abdelmalek, Manal F., Chen Liu, Jonathan Shuster, David R. Nelson, and Nabih R. Asal. “Familial aggregation of insulin resistance in first-degree relatives of patients with nonalcoholic fatty liver disease.” Clin Gastroenterol Hepatol 4, no. 9 (September 2006): 1162–69. https://doi.org/10.1016/j.cgh.2006.06.001.
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    • Samara, Karim, Chen Liu, Consuelo Soldevila-Pico, David R. Nelson, and Manal F. Abdelmalek. “Betaine resolves severe alcohol-induced hepatitis and steatosis following liver transplantation.” Dig Dis Sci 51, no. 7 (July 2006): 1226–29. https://doi.org/10.1007/s10620-006-8038-3.
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    • Machicao, Victor I., Titte R. Srinivas, Alan W. Hemming, Consuelo Soldevila-Pico, Roberto J. Firpi, Alan I. Reed, Giuseppi J. Morelli, David R. Nelson, and Manal F. Abdelmalek. “Impact of implementation of the MELD scoring system on the prevalence and incidence of chronic renal disease following liver transplantation.” Liver Transpl 12, no. 5 (May 2006): 754–61. https://doi.org/10.1002/lt.20686.
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    • Morelli, Giuseppe, Alan Reed, Roberto J. Firpi, Victor Machicao, Manal F. Abdelmalek, Consuelo Soldevilla-Pico, and David R. Nelson. “Late presentation of a biliary tract complication after right hepatic donation resulting in secondary biliary cirrhosis.” Liver Transpl 12, no. 2 (February 2006): 306–9. https://doi.org/10.1002/lt.20687.
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    • Firpi, Roberto J., Haizhen Zhu, Giuseppe Morelli, Manal F. Abdelmalek, Consuelo Soldevila-Pico, Victor I. Machicao, Roniel Cabrera, Alan I. Reed, Chen Liu, and David R. Nelson. “Cyclosporine suppresses hepatitis C virus in vitro and increases the chance of a sustained virological response after liver transplantation.” Liver Transpl 12, no. 1 (January 2006): 51–57. https://doi.org/10.1002/lt.20532.
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    • Firpi, Roberto J., Consuelo Soldevila-Pico, Manal F. Abdelmalek, Giuseppe Morelli, Joel Judah, and David R. Nelson. “Short recovery time after percutaneous liver biopsy: should we change our current practices?” Clin Gastroenterol Hepatol 3, no. 9 (September 2005): 926–29. https://doi.org/10.1016/s1542-3565(05)00294-6.
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    • Lucey, Michael R., Manal F. Abdelmalek, Rosemarie Gagliardi, Darla Granger, Curtis Holt, Igal Kam, Goran Klintmalm, et al. “A comparison of tacrolimus and cyclosporine in liver transplantation: effects on renal function and cardiovascular risk status.” Am J Transplant 5, no. 5 (May 2005): 1111–19. https://doi.org/10.1111/j.1600-6143.2005.00808.x.
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    • Reed, A., R. J. Howard, S. Fujita, D. P. Foley, M. R. Langham, J. D. Schold, D. Nelson, et al. “Liver retransplantation: a single-center outcome and financial analysis.” Transplant Proc 37, no. 2 (March 2005): 1161–63. https://doi.org/10.1016/j.transproceed.2004.11.046.
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    • Firpi, Roberto J., Manal F. Abdelmalek, Consuelo Soldevila-Pico, Roniel Cabrera, Jonathan J. Shuster, Douglas Theriaque, Alan I. Reed, et al. “One-year protocol liver biopsy can stratify fibrosis progression in liver transplant recipients with recurrent hepatitis C infection.” Liver Transpl 10, no. 10 (October 2004): 1240–47. https://doi.org/10.1002/lt.20238.
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    • Abdelmalek, Manal F., Roberto J. Firpi, Consuelo Soldevila-Pico, Alan I. Reed, Alan W. Hemming, Chen Liu, James M. Crawford, Gary L. Davis, and David R. Nelson. “Sustained viral response to interferon and ribavirin in liver transplant recipients with recurrent hepatitis C.” Liver Transpl 10, no. 2 (February 2004): 199–207. https://doi.org/10.1002/lt.20074.
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    • Abdelmalek, Manal F., Tousif M. Pasha, Nizar N. Zein, David H. Persing, Russell H. Wiesner, and David D. Douglas. “Subclinical reactivation of hepatitis B virus in liver transplant recipients with past exposure.” Liver Transpl 9, no. 12 (December 2003): 1253–57. https://doi.org/10.1016/j.lts.2003.09.013.
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    • Nelson, David R., Zhengkun Tu, Consuelo Soldevila-Pico, Manal Abdelmalek, Haizhen Zhu, Yi Ling Xu, Roniel Cabrera, Chen Liu, and Gary L. Davis. “Long-term interleukin 10 therapy in chronic hepatitis C patients has a proviral and anti-inflammatory effect.” Hepatology 38, no. 4 (October 2003): 859–68. https://doi.org/10.1053/jhep.2003.50427.
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    • Rosenberg, Eric I., Girish Mishra, and Manal F. Abdelmalek. “Angiotensin-converting enzyme inhibitor-induced isolated visceral angioedema in a liver transplant recipient.” Transplantation 75, no. 5 (March 15, 2003): 730–32. https://doi.org/10.1097/01.TP.0000048491.67462.DA.
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    • Firpi, Roberto J., Manal F. Abdelmalek, Consuelo Soldevila-Pico, Alan Reed, Alan Hemming, Richard Howard, William Van Der Werf, et al. “Combination of interferon alfa-2b and ribavirin in liver transplant recipients with histological recurrent hepatitis C.” Liver Transpl 8, no. 11 (November 2002): 1000–1006. https://doi.org/10.1053/jlts.2002.34968.
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    • Nelson, D. R., C. Soldevila-Pico, A. Reed, M. F. Abdelmalek, A. W. Hemming, W. J. Van der Werf, R. Howard, and G. L. Davis. “Anti-interleukin-2 receptor therapy in combination with mycophenolate mofetil is associated with more severe hepatitis C recurrence after liver transplantation.” Liver Transpl 7, no. 12 (December 2001): 1064–70. https://doi.org/10.1053/jlts.2001.29414.
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    • Abdelmalek, M. F., P. Angulo, R. A. Jorgensen, P. B. Sylvestre, and K. D. Lindor. “Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: Results of a pilot study.” American Journal of Gastroenterology 96, no. 9 SUPPL. (October 3, 2001): 2711–17. https://doi.org/10.1016/S0002-9270(01)02691-0.
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    • Abdelmalek, M. F., P. Angulo, R. A. Jorgensen, P. B. Sylvestre, and K. D. Lindor. “Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study.” Am J Gastroenterol 96, no. 9 (September 2001): 2711–17. https://doi.org/10.1111/j.1572-0241.2001.04129.x.
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    • Maiwald, M., A. von Herbay, D. H. Persing, P. P. Mitchell, M. F. Abdelmalek, J. N. Thorvilson, D. N. Fredricks, and D. A. Relman. “Tropheryma whippelii DNA is rare in the intestinal mucosa of patients without other evidence of Whipple disease.” Ann Intern Med 134, no. 2 (January 16, 2001): 115–19. https://doi.org/10.7326/0003-4819-134-2-200101160-00011.
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    • O’Duffy, J. D., W. L. Griffing, C. Y. Li, M. F. Abdelmalek, and D. H. Persing. “Whipple's arthritis: direct detection of Tropheryma whippelii in synovial fluid and tissue.” Arthritis Rheum 42, no. 4 (April 1999): 812–17. https://doi.org/10.1002/1529-0131(199904)42:4<812::AID-ANR27>3.0.CO;2-S.
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    • Abdelmalek, M. F., M. E. Harrison, J. B. Gross, J. J. Poterucha, A. A. Gossard, J. R. Spivey, J. Rakela, and K. D. Lindor. “Treatment of chronic hepatitis C with interferon with or without ursodeoxycholic acid: a randomized prospective trial.” J Clin Gastroenterol 26, no. 2 (March 1998): 130–34. https://doi.org/10.1097/00004836-199803000-00009.
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    • Abdelmalek, M. F., B. A. Pockaj, and J. A. Leighton. “Rectal bleeding from a mucous fistula secondary to a Dieulafoy's lesion.” J Clin Gastroenterol 24, no. 4 (June 1997): 259–61. https://doi.org/10.1097/00004836-199706000-00017.
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    • Abdelmalek, M. F., and D. D. Douglas. “Lisinopril-induced isolated visceral angioedema: review of ACE-inhibitor-induced small bowel angioedema.” Dig Dis Sci 42, no. 4 (April 1997): 847–50. https://doi.org/10.1023/a:1018884702345.
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    • Abdelmalek, M. F., and D. D. Douglas. “Alendronate-induced ulcerative esophagitis.” Am J Gastroenterol 91, no. 6 (June 1996): 1282–83.
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    • Abdelmalek, M. F., and P. C. Spittell. “79-year-old woman with blue toes.” Mayo Clin Proc 70, no. 3 (March 1995): 292–95. https://doi.org/10.4065/70.3.292.
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    • Abdelmalek, M., J. Ludwig, and K. D. Lindor. “Two cases from the spectrum of nonalcoholic steatohepatitis.” J Clin Gastroenterol 20, no. 2 (March 1995): 127–30. https://doi.org/10.1097/00004836-199503000-00011.
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  • Conference Papers

    • Ratziu, Vlad, Arun Sanyal, Stephen A. Harrison, Vincent Wai-Sun Wong, Sven Francque, Zachary Goodman, Guruprasad P. Aithal, et al. “Cenicriviroc Treatment for Adults with Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study.” In Hepatology, 2020. https://doi.org/10.1002/hep.31108.
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    • Satapathy, Sanjaya K., Yu Jiang, Uchenna Agbim, Cen Wu, David E. Bernstein, Lewis W. Teperman, Satish K. Kedia, et al. “Posttransplant Outcome of Lean Compared With Obese Nonalcoholic Steatohepatitis in the United States: The Obesity Paradox.” In Liver Transpl, 26:68–79, 2020. https://doi.org/10.1002/lt.25672.
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    • Du, Kuo, Seh-Hoon Oh, Ying Wang, Manal F. Abdelmalek, and Anna Mae Diehl. “INHIBITING xCT/SLC7A11 INDUCES FERROPTOSIS OF MYOFIBROBLASTIC HEPATIC STELLATE CELLS AND PROTECTS AGAINST LIVER FIBROSIS.” In Hepatology, 70:874A-874A. WILEY, 2019.
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    • Glass, Oliver, Ying Wang, Daniel Liu, Cynthia D. Guy, Anna Mae Diehl, and Manal F. Abdelmalek. “EXERCISE BEHAVIOR IN PATIENTS WITH BIOPSY-PROVEN NON-ALCOHOLIC FATTY LIVER DISEASE.” In Hepatology, 70:748A-748A. WILEY, 2019.
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    • Harrison, Stephen A., Eric J. Lawitz, Vincent Wai-Sun Wong, Quentin M. Anstee, Michael H. Trauner, Manuel Romero-Gomez, Bal Bhandari, et al. “CURRENTLY AVAILABLE NONINVASIVE TESTS ACCURATELY STAGE FIBROSIS IN PATIENTS WITH NONALCOHOLIC STEATOHEPATITIS (NASH).” In Hepatology, 70:1349A-1350A. WILEY, 2019.
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    • Moylan, Cynthia A., Kuo Du, Jeongeun Hyun, Kara Wegermann, Manal F. Abdelmalek, Anna Mae Diehl, and Cynthia D. Guy. “EXPRESSION OF BRANCHED CHAIN AMINO ACID TRANSAMINASE 1 (BCAT1) IS INCREASED IN NAFLD FIBROSIS AND CIRRHOSIS AND HEPATOCELLULAR CARCINOMA.” In Hepatology, 70:1335A-1336A. WILEY, 2019.
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    • Wegermann, Kara, Catherine Howe, Ricardo Henao, Ying Wang, Anna Mae Diehl, Manal F. Abdelmalek, and Cynthia A. Moylan. “PRIMARY BILE ACID AND BRANCHED CHAIN AMINO ACID METABOLITES ASSOCIATE WITH DIASTOLIC HEART FAILURE IN NON-ALCOHOLIC FATTY LIVER DISEASE.” In Hepatology, 70:1039A-1039A. WILEY, 2019.
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    • Moylan, Cynthia A., Carole Grenier, Jeongeun Hyun, Kuo Du, Ricardo Henao, Manal F. Abdelmalek, Susan K. Murphy, and Anna Mae Diehl. “DYSREGULATED DNA METHYLATION OF FGFR2, CASP1, AND BCAT1 ASSOCIATES WITH NONALCOHOLIC FATTY LIVER DISEASE SEVERITY AND CAN BE IDENTIFIED IN PERIPHERAL BLOOD.” In Gastroenterology, 156:S1360–61. W B SAUNDERS CO-ELSEVIER INC, 2019.
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    • Wegermann, Kara, Catherine Howe, Ricardo Henao, Ying Wang, Anna Mae Diehl, Manal F. Abdelmalek, and Cynthia A. Moylan. “BRANCHED CHAIN AMINO ACID AND BILE ACID METABOLITES ASSOCIATE WITH FUTURE CLINICAL DECOMPENSATION IN NONALCOHOLIC FATTY LIVER DISEASE.” In Gastroenterology, 156:S1223–S1223. W B SAUNDERS CO-ELSEVIER INC, 2019.
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    • Paredes, Angelo H., James F. Trotter, Mustafa R. Bashir, Guy W. Neff, Manal F. Abdelmalek, Grisell Ortiz-Lasanta, Mark Jaros, et al. “NGM282 Maintains a Durable Off-Treatment Response on Hepatic Steatosis, Inflammation and Fibrogenesis in Patients with Biopsy-Confirmed Nonalcoholic Steatohepatitis: Results of a Multi-Center Phase 2 Dose-Finding Study.” In Hepatology, 68:1460A-1461A. WILEY, 2018.
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    • Abdelmalek, Manal F., Bradley L. Freilich, Stephen A. Harrison, Elizabeth E. Powell, Mary E McCarthy Rinella, Neta Tobis, Dan Peres, Jerry Kanellos, Gadi Lalazar, and Arun J. Sanyal. “Imm-124E Improves Metabolic Endotoxemia and Markers of Liver Injury in Nonalcoholic Steatohepatitis.” In Hepatology, 68:68A-69A. WILEY, 2018.
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    • Abdelmalek, Manal F., Nicolas Lanthier, Mario Chojkier, Johannes Kluwe, Andrew J. Fowell, Jiacheng Yuan, Jean Paul Nicandro, et al. “Cenicriviroc Treatment over 2 Years Results in Clinically Meaningful and Sustained Improvement in Fibrosis in Adults with Nonalcoholic Steatohepatitis and Severe Liver Fibrosis.” In Hepatology, 68:1287A-1287A. WILEY, 2018.
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    • Chalasani, Naga P., Eric J. Lawitz, Manal F. Abdelmalek, Mary E McCarthy Rinella, Stephen A. Harrison, Arun J. Sanyal, Mazen Noureddin, et al. “The Noninvasive Point of Care MBT Accurately Predicts Decompensation Events Better Than MELD in Compensated (MELD < 15) Nash Cirrhotics.” In Hepatology, 68:769A-770A. WILEY, 2018.
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    • Chaudhry, Mohammad, Cynthia A. Moylan, Michael S. Middleton, Alfredo Farjat, Kingshuk Roy Chaudhury, Cynthia D. Guy, Manal F. Abdelmalek, Rohit Loomba, Claude B. Sirlin, and Mustafa Bashir. “Quantifying the Placebo Effect on Liver Fat Using Magnetic Resonance Imaging-Proton Density Fat Fraction in NAFLD Clinical Trials.” In Hepatology, 68:68A-68A. WILEY, 2018.
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    • Halegoua-De Marzio, Dina, Paul J. Thuluvath, Manal F. Abdelmalek, Courtney Van Biene, Reshma Shringarpure, and Leigh MacConell. “Obeticholic Acid Was Safe and Well Tolerated in Patients with Nonalcoholic Steatohepatitis and Compensated Cirrhosis: A Secondary Analysis of the Control Study.” In Hepatology, 68:45A-45A. WILEY, 2018.
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    • Moylan, Cynthia A., Patricia A. Sorrow, Alisha Mavis, Mustafa Bashir, Dereje Jima, Rachel Maguire, Erol Bozdogan, et al. “Obesity and Nonalcoholic Fatty Liver Disease in Childhood Associate with Altered DNA Methylation in Early Life.” In Hepatology, 68:949A-950A. WILEY, 2018.
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    • Neuschwander-Tetri, Brent A., Kris V. Kowdley, Arun J. Sanyal, Manal F. Abdelmalek, Norah Terrault, Arthur J. McCullough, Peter Wang, et al. “Efficacy and Safety of Obeticholic Acid in Patients with Non-Alcoholic Steatohepatitis and Significant Fibrosis Using Endpoint Definitions and Populations Accepted for Registrational Studies.” In Hepatology, 68:952A-952A. WILEY, 2018.
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    • Bae, Andrew, Ricardo Henao, Ayako Suzuki, Cynthia A. Moylan, Cynthia D. Guy, Anna Mae Diehl, and Manal F. Abdelmalek. “STATIN USE AND LIVER INJURY IN NONALCOHOLIC FATTY LIVER DISEASE: RESULTS OF A PAIRED CLINICAL AND GENE EXPRESSION PROFILE ANALYSIS.” In Gastroenterology, 154:S1085–86. W B SAUNDERS CO-ELSEVIER INC, 2018.
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    • DEPAOLI, A. L. E. X., S. T. E. P. H. E. N. J. ROSSI, L. E. I. LING, S. T. E. P. H. E. N. A. HARRISON, M. A. N. A. L. F. ABDELMALEK, M. A. R. K. R. JAROS, and R. A. N. S. I. SOMARATNE. “NGM282 Significantly Reduces Hepatic Steatosis Independent of Type 2 Diabetes (T2D) Status or Statin Usage—Results from a Phase 2 Trial in Patients with Nonalcoholic Steatohepatitis (NASH).” In Diabetes, 67:1-LB. American Diabetes Association, 2018. https://doi.org/10.2337/db18-1-lb.
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    • Du, Kuo, Richard Premont, Jeongeun Hyun, Mariana V. Machado, Cynthia A. Moylan, Manal F. Abdelmalek, Cynthia D. Guy, and Anna Mae Diehl. “PATHPHYSIOLOGICAL ROLE OF GLUTAMINOLYSIS IN HUMAN NAFLD PROGRESSION.” In Gastroenterology, 154:S950–51. W B SAUNDERS CO-ELSEVIER INC, 2018.
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    • Ridder, Gustaaf de, Ayako Suzuki, Liyan Xu, Diana Cardona, Jeff Groth, Rupa Ray, Manal F. Abdelmalek, Salvatore V. Pizzo, and Cynthia Guy. “GRP78 Immunohistochemistry Outperforms HSP70 for the Diagnosis of Cirrhotic- and Noncirrhotic-HCC.” In Modern Pathology, 31:632–632. NATURE PUBLISHING GROUP, 2018.
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    • Ridder, Gustaaf de, Ayako Suzuki, Liyan Xu, Diana Cardona, Jeff Groth, Rupa Ray, Manal F. Abdelmalek, Salvatore V. Pizzo, and Cynthia Guy. “GRP78 Immunohistochemistry Outperforms HSP70 for the Diagnosis of Cirrhotic- and Noncirrhotic-HCC.” In Laboratory Investigation, 98:632–632. NATURE PUBLISHING GROUP, 2018.
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    • Schild, Michael, Liyan Xu, Ayako Suzuki, Diana Cardona, Lani Clinton, Shannon McCall, Avani Pendse, et al. “Sonic Hedgehog Immunohistochemistry Improves Inter-observer Agreement for Ballooning and the Diagnosis of Nonalcoholic Steatohepatitis (NASH) among Less Experienced Liver Pathologists.” In Modern Pathology, 31:648–49. NATURE PUBLISHING GROUP, 2018.
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    • Schild, Michael, Liyan Xu, Ayako Suzuki, Diana Cardona, Lani Clinton, Shannon McCall, Avani Pendse, et al. “Sonic Hedgehog Immunohistochemistry Improves Inter-observer Agreement for Ballooning and the Diagnosis of Nonalcoholic Steatohepatitis (NASH) among Less Experienced Liver Pathologists.” In Laboratory Investigation, 98:648–49. NATURE PUBLISHING GROUP, 2018.
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    • Abdelmalek, Manal F., Anna Mae Diehl, Cynthia D. Guy, Dana Portenier, Ranjan Sudan, Xiaojun Li, Larry Mimms, and Anjali Jain. “Serum-Based Biomarker Accurately Stratifies Hepatic Fibrosis in Patients with Nonalcoholic Steatohepatitis.” In Hepatology, 66:55A-56A. WILEY, 2017.
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    • Abdelmalek, Manal F., Edgar D. Charles, Brent A. Neuschwander-Tetri, Dina Halegoua-DeMarzio, Arun J. Sanyal, Robert W. Herring, Eric Lawitz, et al. “Baseline Serum Pro-C3 Predicts Response to BMS-986036 (peg-FGF21): A Secondary Analysis of a Multi-Center Clinical Trial in Non-Alcoholic Steatohepatitis (NASH).” In Hepatology, 66:1114A-1115A. WILEY, 2017.
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    • Abdelmalek, Manal F., Melanie Thompson, Joseph C. Gathe, Eric Lefebvre, Star Seyedkazemi, Netanya Sandler Utay, and Sven Francque. “Favorable safety and tolerability of the dual CCR2/5 antagonist cenicriviroc in over 1000 subjects treated to date.” In Hepatology, 66:1177A-1177A. WILEY, 2017.
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    • Abdelmalek, Manal F., Ricardo Henao, Ying Wang, Cynthia D. Guy, Mustafa R. Bashir, Richard Johnson, Anna Mae Diehl, and Brian Soher. “Fructose-Related Hepatic ATP Depletion Induces Hyperuricemia in Healthy Volunteers and Patients with Biopsy-Proven Nonalcoholic Fatty Liver Disease.” In Hepatology, 66:1104A-1105A. WILEY, 2017.
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    • Bosch, Jaime, Manal F. Abdelmalek, Mitchell L. Shiffman, Anna Mae Diehl, Stephen H. Caldwell, Don C. Rockey, Reem Ghalib, et al. “Variability in measurement of hepatic venous pressure gradient (HVPG) in patients with compensated cirrhosis due to NASH: Results from a randomized, controlled trial.” In Hepatology, 66:252A-252A. WILEY, 2017.
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    • Bosch, Jaime, Stephen A. Harrison, Manal F. Abdelmalek, Mitchell L. Shiffman, Anna Mae Diehl, Stephen H. Caldwell, Don C. Rockey, et al. “Hepatic venous pressure gradient (HVPG) predicts clinical disease progression in patients with compensated cirrhosis due to NASH.” In Hepatology, 66:244A-245A. WILEY, 2017.
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    • Goodman, Zachary D., Lakshmi Alaparthi, Fanny Monge, Keyur Patel, Rohit Loomba, Stephen H. Caldwell, Eric Lawitz, et al. “Prospective validation of hepatic collagen content for the prediction of clinical disease progression.” In Hepatology, 66:1111A-1112A. WILEY, 2017.
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    • Guy, Cynthia D., Ayako Suzuki, Marzena Swiderska-Syn, Manal F. Abdelmalek, and Anna Mae Diehl. “Hepatocellular injury and senescence in NASH are linked to Hedgehog and Hippo pathway activity and accumulation of hepatic progenitor cells.” In Hepatology, 66:1153A-1154A. WILEY, 2017.
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    • Harrison, Stephen A., Manal F. Abdelmalek, Anna Mae Diehl, Stephen Caldwell, Mitchell L. Shiffman, Reem Ghalib, Eric Lawitz, et al. “Prospective validation of the Enhanced Liver Fibrosis (ELF) test for the prediction of disease progression in patients with nonalcoholic steatohepatitis (NASH) and advanced fibrosis.” In Hepatology, 66:1120A-1121A. WILEY, 2017.
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    • Li, Xiaoyi, Cynthia A. Moylan, Susan S. Baker, Wensheng Liu, Robert D. Baker, Susan K. Murphy, Manal F. Abdelmalek, Ruixin Zhu, Anna Mae Diehl, and Lixin Zhu. “Altered liver methylome and transcriptome provide evidence for epigenetic contribution to NAFLD pathogenesis.” In Hepatology, 66:1071A-1072A. WILEY, 2017.
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    • Loomba, Rohit, Eric Lawitz, Reem Ghalib, Magdy Elkhashab, Stephen H. Caldwell, Manal F. Abdelmalek, Kris V. Kowdley, et al. “Reductions in liver stiffness by magnetic resonance elastography (MRE) predict fibrosis improvement in a multi-center clinical trial of subjects with nonalcoholic steatohepatitis (NASH).” In Hepatology, 66:1109A-1110A. WILEY, 2017.
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    • Loomba, Rohit, Manal F. Abdelmalek, James F. Trotter, Angelo H. Paredes, Mark Jaros, Lei Ling, Stephen J. Rossi, Alex M. DePaoli, Mary E. Rinella, and Stephen A. Harrison. “NGM282 Significantly Reduces Hepatic Steatosis Independent of Baseline Patient Characteristics and Highly Correlates with Markers of FGFR4 Target Engagement: Results from a Phase 2 Trial in Biopsy-Confirmed NASH Patients.” In Hepatology, 66:1152A-1152A. WILEY, 2017.
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    • Moylan, Cynthia A., Alisha M. Mavis, Mustafa R. Bashir, David Malik, Erol Bozdogan, Stephanie Buie, Cathrine Hoyo, Anna Mae Diehl, Susan K. Murphy, and Manal F. Abdelmalek. “Visceral and subcutaneous adipose tissue measurements associate with increased metabolic risk for NAFLD in pre-pubertal obese children.” In Hepatology, 66:665A-665A. WILEY, 2017.
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    • Rinella, Mary E., James F. Trotter, Guy Neff, Grisell Ortiz-Lasanta, Manal F. Abdelmalek, Marcelo Kugelmas, Angelo H. Paredes, et al. “NGM282 Induces Low Density Lipoprotein Cholesterol (LDLc) Changes, Consistent with Potent FGFR4 Signaling, which are Rapidly Mitigated with Statin Therapy in Patients with Biopsy-Confirmed Nonalcoholic Steatohepatitis (NASH).” In Hepatology, 66:1132A-1133A. WILEY, 2017.
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    • Sanyal, Arun J., Edgar D. Charles, Brent A. Neuschwander-Tetri, Rohit Loomba, Stephen A. Harrison, Manal F. Abdelmalek, Eric Lawitz, et al. “BMS-986036 (pegylated FGF21) in patients with non-alcoholic steatohepatitis: A phase 2 study.” In Hepatology, 66:104A-105A. WILEY, 2017.
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    • Vuppalanchi, Raj, Eric Lawitz, Manal F. Abdelmalek, Mary E. Rinella, Stephen A. Harrison, Michael J. Ryan, Peter G. Traber, Guadalupe Garcia-Tsao, and Naga P. Chalasani. “Liver Stiffness Measured By Vibration Controlled Transient Elastography Is An Excellent Surrogate for Identifying Clinically Significant Portal Hypertension In Patients With Compensated NASH Cirrhosis.” In Hepatology, 66:245A-245A. WILEY, 2017.
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    • Wegermann, Kara, Cynthia A. Moylan, Jiayin Zheng, Manal F. Abdelmalek, Shein-Chung Chow, Cynthia D. Guy, Anna Mae Diehl, and Ayako Suzuki. “Gender and menopause significantly modify effects of metabolism-related SNPs on fibrosis stage in adult patients with nonalcoholic fatty liver disease (NAFLD).” In Hepatology, 66:55A-55A. WILEY, 2017.
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    • Younossi, Zobair M., Maria Stepanova, Arun J. Sanyal, Stephen A. Harrison, Vlad Ratziu, Bryan J. McColgan, Robert P. Myers, et al. “Predictors of Fibrosis Progression and Regression by Histology and Morphometrically Quantified Collagen in Patients with Nonalcoholic Steatohepatitis (NASH) and Advanced Fibrosis.” In Hepatology, 66:1171A-1171A. WILEY, 2017.
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    • Younossi, Zobair M., Maria Stepanova, Stephen A. Harrison, Arun J. Sanyal, Vlad Ratziu, Bryan J. McColgan, Robert P. Myers, et al. “Subjects with Non-alcoholic Fatty Liver Disease and Severe Fibrosis Face a Significant Number of Adverse Events: Cryptogenic Cirrhosis and Severe Steatofibrosis.” In Hepatology, 66:1154A-1155A. WILEY, 2017.
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    • Moylan, Cynthia A., Ricardo Henao Giraldo, Susan K. Murphy, Anna Mae Diehl, and Manal F. Abdelmalek. “Differential DNA Methylation in Whole Blood Reflects that in Liver and Distinguishes Patients with Advanced NAFLD Fibrosis from Those with Normal Histology: A Potential Non-Invasive Tool.” In Gastroenterology, 152:S1069–70. Elsevier BV, 2017. https://doi.org/10.1016/s0016-5085(17)33611-9.
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    • Sanyal, Arun, Stephen A. Harrison, Vlad Ratziu, Manal F. Abdelmalek, Anna Mae Diehl, Stephen H. Caldwell, Mitchell L. Shiffman, et al. “Changes in Fibrosis, but not the Nafld Activity Score (NAS), are Associated with Disease Progression in Patients with Nonalcoholic Steatohepatitis (NASH) and Advanced Fibrosis.” In Gastroenterology, 152:S1055–S1055. Elsevier BV, 2017. https://doi.org/10.1016/s0016-5085(17)33563-1.
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    • Sanyal, Arun J., Vlad Ratziu, Stephen Harrison, Manal F. Abdelmalek, Guruprasad P. Aithal, Juan Caballeria, Sven M. Francque, et al. “Cenicriviroc placebo for the treatment of non-alcoholic steatohepatitis with liver fibrosis: Results from the Year 1 primary analysis of the Phase 2b CENTAUR study Abstracts.” In Hepatology, 64:1118A-1119A. WILEY, 2016.
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    • Corey, Kathleen E., Katherine P. Yates, Manal F. Abdelmalek, Arun J. Sanyal, Brent A. Tetri, Kris V. Kowdley, Oscar Cummings, James Tonascia, and Naga P. Chalasani. “Longitudinal relationship between changes in liver histology and renal function in adults with NASH: The NASH Clinical Research Network Experience.” In Hepatology, 64:20A-20A. WILEY, 2016.
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    • Hameed, Bilal, Norah Terrault, Rohit Loomba, Arthur J. McCullough, Manal F. Abdelmalek, Kris V. Kowdley, Brent A. Tetri, et al. “Subgroup Analysis Comparing Obeticholic Acid versus Placebo for Fibrosis Improvement: a Post-hoc Analysis of the FLINT Trial.” In Hepatology, 64:541A-542A. WILEY, 2016.
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    • Moylan, Cynthia A., Kara J. Wegermann, Ricardo G. Henao, Susan K. Murphy, Anna Mae Diehl, and Manal F. Abdelmalek. “BCAT1 Is Associated with Clinical Decompensation in Nonalcoholic Fatty Liver Disease: a Pilot Study.” In American Journal of Gastroenterology, 111:S381–S381. Ovid Technologies (Wolters Kluwer Health), 2016. https://doi.org/10.14309/00000434-201610001-00871.
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    • Patel, Yuval A., Ricardo Henao, Cynthia A. Moylan, Cynthia D. Guy, Dawn L. Piercy, Anna Mae Diehl, and Manal F. Abdelmalek. “Vitamin D is Not Associated with Histologic Severity in NAFLD: Results of a Paired Clinical and Hepatic Gene Expression Profile Analysis.” In Hepatology, 64:577A-577A. WILEY, 2016.
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    • Suzuki, Ayako, Horace J. Spencer, Cynthia A. Moylan, Jonathan A. Dranoff, Manal F. Abdelmalek, Cynthia D. Guy, and Anna Mae Diehl. “Hepatic estrogen transcriptional activity and estrogen receptor a gene expression are negatively correlated with fibrosis stage in patients with nonalcoholic fatty liver disease (NAFLD).” In Hepatology, 64:105A-105A. WILEY, 2016.
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    • Vuppalanchi, Raj, Manal F. Abdelmalek, Eric Lawitz, Peter G. Traber, Adam E. Allgood, Stephen A. Harrison, Zachary D. Goodman, Naga P. Chalasani, and Guadalupe Garcia-Tsao. “Vibration-Controlled Transient Elastography (VCTE) is Useful in Identifying Clinically Significant Portal Hypertension in Patients with NASH Cirrhosis.” In Hepatology, 64:844A-845A. WILEY, 2016.
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    • Wegermann, Kara, Ricardo Henao, Yiping Pan, Anna Mae Diehl, Manal F. Abdelmalek, and Cynthia A. Moylan. “BCAT1 is Associated with Clinical Decompensation in NAFLD: A Pilot Study.” In Hepatology, 64:577A-577A. WILEY, 2016.
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    • Kowdley, Kris V., Manal F. Abdelmalek, Arthur McCullough, Rohit Loomba, Bilal Hameed, Naga P. Chalasani, Brent Neuschwander-Tetri, et al. “Mo1557 Evaluation of Effects of Concomitant Medications for NASH and Associated Comorbidities on Histological Improvements With Obeticholic Acid.” In Gastroenterology, 150:S1144–S1144. Elsevier BV, 2016. https://doi.org/10.1016/s0016-5085(16)33861-6.
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    • Abdelmalek, Manal F., Kris V. Kowdley, Norah Terrault, Brent A. Neuschwander-Tetri, Arun J. Sanyal, Rohit Loomba, Xiaohong Yan, Reshma Shringarpure, David Shapiro, and Arthur J. McCullough. “Effect of biopsy length on histological response assessment in NASH trials: A secondary analysis of FLINT Trial.” In Hepatology, 62:1256A-1257A. WILEY-BLACKWELL, 2015.
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    • Bosch, Jaime, Vlad Ratziu, Don C. Rockey, Reem H. Ghalib, Paul J. Thuluvath, Ingolf Schiefke, Steven L. Flamm, et al. “Correlation between noninvasive markers of fibrosis and the hepatic venous pressure gradient (HVPG) in patients with compensated cirrhosis due to nonalcoholic steatohepatitis (NASH).” In Hepatology, 62:578A-578A. WILEY-BLACKWELL, 2015.
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    • Chalasani, Naga P., Rohit Loomba, Norah Terrault, Arthur J. McCullough, Manal F. Abdelmalek, Kris V. Kowdley, Brent A. Neuschwander-Tetri, et al. “Longitudinal changes in FIB-4 and improvement in fibrosis stage with obeticholic acid: A secondary analysis of FLINT Trial.” In Hepatology, 62:332A-333A. WILEY-BLACKWELL, 2015.
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    • Goodman, Zachary D., Lakshmi Alaparthi, Fanny Monge, Keyur Patel, Rohit Loomba, Stephen H. Caldwell, Eric Lawitz, et al. “Correlations between hepatic morphometric collagen content, histologic fibrosis staging, and serum markers in patients with advanced fibrosis due to nonalcoholic steatohepatitis (NASH).” In Hepatology, 62:906A-906A. WILEY-BLACKWELL, 2015.
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    • Harrison, Stephen A., Arun J. Sanyal, Sven M. Francque, Pierre Bedossa, Lawrence Serfaty, Manuel Romero-Gomez, Paul Cales, et al. “Beneficial effects of the dual PPAR alpha-delta agonist, GFT505, on hepatic and cardiometabolic markers in adult NASH patients.” In Hepatology, 62:291A-292A. WILEY-BLACKWELL, 2015.
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    • Harrison, Stephen A., Zachary D. Goodman, Vlad Ratziu, Rohit Loomba, Anna Mae Diehl, Eric Lawitz, Holger Hinrichsen, et al. “Serum lysyl oxidase-like-2 (sLOXL2) levels correlate with fibrosis stage in patients with nonalcoholic steatohepatitis (NASH).” In Hepatology, 62:910A-910A. WILEY-BLACKWELL, 2015.
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    • Hasanaliyeva, Nigar, Keyur Patel, Cynthia D. Guy, Hans J. Gruss, Robert Streilein, Russell Hall, Anna Mae Diehl, and Manal F. Abdelmalek. “IL-8 and MCP1 are Independently Associated with Hepatic Fibrosis in Patients with Nonalcoholic Fatty Liver Disease.” In Hepatology, 62:1265A-1265A. WILEY-BLACKWELL, 2015.
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    • Henao, Ricardo, Nigar Hasanaliyeva, Lauren N. Bell, Jacob Wulff, Regis Perichon, Cynthia A. Moylan, James T. Lu, Cynthia D. Guy, Anna Mae Diehl, and Manal F. Abdelmalek. “Plasma Metabolomic Profiles Predict Advanced Hepatic Fibrosis in Patients with Nonalcoholic Fatty Liver Disease.” In Hepatology, 62:290A-291A. WILEY-BLACKWELL, 2015.
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    • Loomba, Rohit, Arun J. Sanyal, Kris V. Kowdley, Norah Terrault, Naga P. Chalasani, Manal F. Abdelmalek, Arthur J. McCullough, et al. “Predictors of improvement in NAFLD Activity Score to obeticholic acid: A secondary analysis of FLINT Trial.” In Hepatology, 62:1257A-1257A. WILEY-BLACKWELL, 2015.
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    • Moylan, Cynthia A., Susan K. Murphy, Carole Grenier, Manal F. Abdelmalek, and Anna Mae Diehl. “DNA Methylation Profiles of Fibrosis-Associated Gene in Blood Reflects Liver Fibrosis Severity in Human Nonalcoholic Fatty Liver Disease.” In Hepatology, 62:648A-649A. WILEY-BLACKWELL, 2015.
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    • Ratziu, Vlad, Arun J. Sanyal, Rohit Loomba, Stephen H. Caldwell, Reem H. Ghalib, Dawn M. Torres, Arthur J. McCullough, et al. “Characterization of insulin resistance in patients with advanced fibrosis due to nonalcoholic steatohepatitis (NASH).” In Hepatology, 62:1298A-1299A. WILEY-BLACKWELL, 2015.
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    • Ratziu, Vlad, Stephen A. Harrison, Sven M. Francque, Pierre Bedossa, Lawrence Serfaty, Manuel Romero-Gomez, Paul Cales, et al. “An international, phase 2 randomized controlled trial of the dual PPAR alpha-delta agonist GFT505 in adult patients with NASH.” In Hepatology, 62:262A-263A. WILEY-BLACKWELL, 2015.
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    • Sanyal, Arun J., Stephen A. Harrison, Sven M. Francque, Pierre Bedossa, Lawrence Serfaty, Manuel Romero-Gomez, Paul Cales, et al. “The hepatic and extra-hepatic profile of resolution of steatohepatitis induced by GFT-505.” In Hepatology, 62:1252A-1252A. WILEY-BLACKWELL, 2015.
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    • Sanyal, Arun J., Zachary D. Goodman, Manal F. Abdelmalek, Stephen A. Harrison, Don C. Rockey, Anna Mae Diehl, Stephen H. Caldwell, et al. “Clinical and histologic correlates of the hepatic venous pressure gradient (HVPG) in patients with compensated cirrhosis due to nonalcoholic steatohepatitis (NASH).” In Hepatology, 62:577A-577A. WILEY-BLACKWELL, 2015.
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    • Vuppalanchi, Raj, Mohammad S. Siddiqui, Erin K. Hallinan, Manal F. Abdelmalek, Brent A. Neuschwander-Tetri, Rohit Loomba, Kris V. Kowdley, et al. “Transient Elastography is Feasible with High Success Rate for Evaluation of Non-Alcoholic Fatty Liver Disease (NAFLD) in a Multicenter Setting.” In Hepatology, 62:1290A-1290A. WILEY-BLACKWELL, 2015.
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    • Zhu, Ruixin, Susan S. Baker, Cynthia A. Moylan, Manal F. Abdelmalek, Cynthia D. Guy, Fausto Zamboni, Dingfeng Wu, et al. “Systematic Analysis of NAFLD Transcriptome Revealed Elevated Expression of Alcohol Metabolizing Genes in Mild and Severe NAFLD Livers.” In Gastroenterology, 148:S1054–S1054. W B SAUNDERS CO-ELSEVIER INC, 2015.
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    • Kochhar, Sweta, Manal F. Abdelmalek, Cynthia D. Guy, Dawn Piercy, Yiping Pan, Anna Mae Diehl, and Ayako Suzuki. “Associations of Sleep Duration and Sleep Quality With Clinical and Histologic Features of Nonalcoholic Fatty Liver Disease (NAFLD).” In Gastroenterology, 146:S931–S931. W B SAUNDERS CO-ELSEVIER INC, 2014.
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    • Yang, Ju Dong, Manal F. Abdelmalek, Cynthia D. Guy, Ryan M. Gill, Katherine P. Yates, Aynur Unalp, Joel E. Lavine, Anna Mae Diehl, and Ayako Suzuki. “Associations of Sex and Menopause With Histologic Severity of Necroinflammation and Portal Inflammation Among Patients With Nonalcoholic Fatty Liver Disease (NAFLD).” In Gastroenterology, 146:S945–S945. W B SAUNDERS CO-ELSEVIER INC, 2014.
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    • Yang, Ju Dong, Manal F. Abdelmalek, Herbert Pang, Cynthia D. Guy, Alastair D. Smith, Anna Mae Diehl, and Ayako Suzuki. “Gender and menopause impact severity of fibrosis among patients with nonalcoholic steatohepatitis.” In Hepatology, 59:1406–14, 2014. https://doi.org/10.1002/hep.26761.
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    • Bohinc, Brittany, Gregory A. Michelotti, Guanhua Xie, Herbert Pang, Ayako Suzuki, Cynthia D. Guy, Dawn L. Piercy, et al. “Repair-related Activation of Hedgehog Signaling in Stromal Cells Promotes Intrahepatic Hypothyroidism.” In Hepatology, 60:411A-412A. WILEY-BLACKWELL, 2014.
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    • Deng, Y., M. L. Palmeri, N. C. Rouze, S. J. Rosenzweig, M. F. Abdelmalek, and K. R. Nightingale. “Analyzing the impact of increasing Mechanical Index (MI) and energy deposition on shear wave speed (SWS) reconstruction in human liver.” In Ieee International Ultrasonics Symposium, Ius, 719–22, 2014. https://doi.org/10.1109/ULTSYM.2014.0177.
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    • Klair, Jagpal S., Ju Dong Yang, Manal F. Abdelmalek, Cynthia D. Guy, Ryan M. Gill, Katherine P. Yates, Aynur Unalp-Arida, et al. “Risk of severe fibrosis is associated with age at menopause in nonalcoholic fatty liver disease (NAFLD).” In Hepatology, 60:621A-621A. WILEY-BLACKWELL, 2014.
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    • Urban, Thomas J., Cynthia A. Moylan, Matthew Rein, Manal F. Abdelmalek, David B. Goldstein, and Anna Mae Diehl. “Whole Exome Sequencing of Extreme Phenotypes of NAFLD Identifies Potential Genetic Risk Factors for Advanced Hepatic Fibrosis.” In Hepatology, 60:744A-744A. WILEY-BLACKWELL, 2014.
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    • Guy, Cynthia D., Ayako Suzuki, Manal F. Abdelmalek, James Burchette, and Anna Mae Diehl. “Hedgehog Pathway Targeted by Vitamin E Therapy in NASH.” In Hepatology, 58:249A-249A. WILEY-BLACKWELL, 2013.
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    • Garrett, Melanie E., Cynthia A. Moylan, Jason Gibson, Hyuna Yang, Herbert Pang, Andrew Dellinger, Ayako Suzuki, et al. “Expression QTL analysis of a gene expression signature which predicts advanced non-alcoholic fatty liver disease.” In Hepatology, 56:267A-268A. WILEY-BLACKWELL, 2012.
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    • Suzuki, Ayako, Cynthia D. Guy, Herbert Pang, Alastair D. Smith, Anna Mae Diehl, and Manal F. Abdelmalek. “Impact of Gender and Menopause on Histologic Severity of Inflammation and Injury in patients with Nonalcoholic Fatty Liver Disease.” In Hepatology, 56:901A-901A. WILEY-BLACKWELL, 2012.
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    • Moylan, Cynthia A., Hyuna Yang, Herbert Pang, Andrew Dellinger, Ayako Suzuki, Hans L. Tillmann, Cynthia D. Guy, et al. “Epigenetic Regulation of Gene Expression in NAFLD.” In Gastroenterology, 142:S929–S929. W B SAUNDERS CO-ELSEVIER INC, 2012.
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    • Corbin, Karen D., Melanie D. Spencer, Kerry-Ann da Costa, Wei Sha, Manal F. Abdelmalek, Yiping Pan, Ayako Suzuki, et al. “Genotype-based hierarchical clustering reveals a panel of polymorphisms in one carbon metabolism that are associated with obesity.” In Faseb Journal, Vol. 26, 2012.
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    • Shah, Ketan K., Ayako Suzuki, Jeffrey B. Schwimmer, Aynur Unalp, Cynthia D. Guy, Jean P. Molleston, Peter F. Whitington, Richard Johnson, Anna Mae Diehl, and Manal F. Abdelmalek. “DOSE DEPENDENT ASSOCIATION OF FRUCTOSE CONSUMPTION WITH HYPERURICEMIA AND INSULIN RESISTANCE IN CHILDREN WITH NAFLD.” In Hepatology, 54:1116A-1116A. WILEY-BLACKWELL, 2011.
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    • Moylan, Cynthia A., Andrew Dellinger, Herbert Pang, Ayako Suzuki, Hans L. Tillmann, Daniel Hampton, Yuping Chen, et al. “Modest Alcohol Consumption Attenuates Expression of Fibrosis-Associated Genes in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD).” In Gastroenterology, 140:S914–15. W B SAUNDERS CO-ELSEVIER INC, 2011.
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    • Zdanowicz, Marzena, Ayako Suzuki, Cynthia D. Guy, Jeffrey Schwimmer, Manal F. Abdelmalek, Joel E. Lavine, and Anna Mae Diehl. “Hedgehog Pathway Activation is Associated With Advanced Fibrosis in Pediatric NAFLD.” In Gastroenterology, 140:S987–S987. W B SAUNDERS CO-ELSEVIER INC, 2011.
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    • Corbin, Karen D., Kerry-Ann da Costa, Wei Sha, Manal F. Abdelmalek, Anna Mae Diehl, and Steven H. Zeisel. “Single nucleotide polymorphisms affecting phosphatidylcholine transport are associated with obesity.” In Faseb Journal, Vol. 25. FEDERATION AMER SOC EXP BIOL, 2011.
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    • Abdelmalek, Manal F., Ayako Suzuki, Silke Schmidt, Jacqueline Rimmler, Aynur Unalp, Cynthia D. Guy, Richard Johnson, Michael A. Hauser, and Anna Mae Diehl. “FRUCTOKINASE POLYMORPHISMS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE ARE ASSOCIATED WITH DECREASED URIC ACID AND THE PRESENCE OF HEPATIC FIBROSIS.” In Hepatology, 52:644A-645A. WILEY-BLACKWELL, 2010.
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    • Moylan, Cynthia A., Manal F. Abdelmalek, Herbert Pang, Andrew Dellinger, Steve S. Choi, Alessia Omenetti, Yuping Chen, et al. “SIGNALS FROM THE FIBROTIC LIVER IN PATIENTS WITH NAFLD MAY PROMOTE DIABETES AND OBESITY.” In Hepatology, 52:1049A-1050A. WILEY-BLACKWELL, 2010.
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    • Moylan, Cynthia A., Steve S. Choi, Andrew Dellinger, Herbert Pang, Manal F. Abdelmalek, Daniel Hampton, Yuping Chen, et al. “CONSERVED GENE EXPRESSION PATTERNS IN MYOFIBROBLASTIC MURINE AND HUMAN HEPATIC STELLATE CELLS AND NAFLD PATIENTS WITH LIVER FIBROSIS COMPATIBLE WITH EPITHELIAL-TO-MESENCHYMAL LIKE TRANSITION.” In Hepatology, 52:1286A-1287A. WILEY-BLACKWELL, 2010.
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    • Piercy, Dawn L., Ayako Suzuki, Jing Feng, Yiping Pan, Cynthia D. Guy, Anna Mae Diehl, Ambrose A. Chiang, and Manal F. Abdelmalek. “OBSTRUCTIVE SLEEP APNEA WORSENS HEPATIC INFLAMMATION AND FIBROSIS IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE.” In Hepatology, 52:631A-631A. WILEY-BLACKWELL, 2010.
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    • Suzuki, Ayako, Martin Binks, Alessia Omenetti, Cynthia D. Guy, Aurora D. Pryor, Yiping Pan, Melissa M. Smith, Anna Mae Diehl, and Manal F. Abdelmalek. “DEPRESSION AND ANXIETY SCORES ARE INDEPENDENTLY ASSOCIATED WITH HISTOLOGIC SEVERITY IN PATIENTS WITH NONALCOHOLIC FATTY LIVER DISEASE.” In Hepatology, 52:626A-626A. WILEY-BLACKWELL, 2010.
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    • Abdelmalek, Manal F., Mariana Lazo, Susanne Bonekamp, Anna Mae Diehl, and Jeanne M. Clark. “INCREASED DIETARY FRUCTOSE IMPAIRS HEPATIC ATP HOMEOSTASIS IN NAFLD.” In Hepatology, 50:777A-777A. JOHN WILEY & SONS INC, 2009.
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    • Suzuki, Ayako, Cynthia D. Guy, Alastair D. Smith, Eric J. DeMaria, Yiping Pan, Melissa M. Smith, Anna Mae Diehl, and Manal F. Abdelmalek. “GENDER AND HORMONAL STATUS ARE ASSOCIATED WITH SEVERITY OF HISTOLOGIC FEATURES AMONG PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE.” In Hepatology, 50:772A-773A. JOHN WILEY & SONS INC, 2009.
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    • Wang, Michael, Mark Palmeri, Ned Rouze, Veronica Rotemberg, Barry Moser, Cynthia D. Guy, Anna Mae Diehl, Manal F. Abdelmalek, and Kathryn Nightingale. “NON-INVASIVE ASSESSMENT OF LIVER FIBROSIS WITH QUANTITATIVE ACOUSTIC RADIATION FORCE METHODS.” In Hepatology, 50:743A-744A. JOHN WILEY & SONS INC, 2009.
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    • Suzuki, Ayako, Manal F. Abdelmalek, Cynthia D. Guy, Jeffrey Schwimmer, Joel E. Lavine, A. O. Scheimann, and Anna Mae Diehl. “Sexual Development and Its Influence On Regional Anthropometric Measures and Histologic Features Among Pediatric Patients with NAFLD.” In Gastroenterology, 136:A845–A845. W B SAUNDERS CO-ELSEVIER INC, 2009.
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    • Abdelmalek, Manal F., Keith D. Lindor, Matthew C. Cave, Keith C. Falkner, Rehan Khan, and Craig J. McClain. “HIGH-DOSE BETAINE TREATMENT DOES NOT POSITIVELY INFLUENCE SECOND HIT MECHANISMS IN NASH.” In Hepatology, 48:817A-817A. JOHN WILEY & SONS INC, 2008.
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    • Jung, Youngmi, Cynthia D. Guy, Liu Yang, Manal F. Abdelmalek, and Anna Mae Diehl. “PROGRESSIVE HEDGEHOG PATHWAY ACTIVATION ACCOMPANIES THE DUCTULAR REACTION DURING NAFLD PROGRESSION IN MICE AND HUMANS.” In Hepatology, 48:829A-829A. JOHN WILEY & SONS INC, 2008.
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    • Suzuki, Ayako, Manal F. Abdelmalek, Cynthia D. Guy, and Anna Mae Diehl. “GENDER-SPECIFIC ASSOCIATIONS BETWEEN REGIONAL ANTHROPOMETRIC MEASURES AND HEPATIC FIBROSIS IN PATIENTS WITH NAFLD.” In Hepatology, 48:804A-804A. JOHN WILEY & SONS INC, 2008.
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    • Abdelmalek, Manal F., Schuyler O. Sanderson, Paul Angulo, Chen Liu, Joy Peter, Jill Keach, and Keith D. Lindor. “Betaine for treatment of nonalcoholic steatohepatitis: Results of a randomized placebo controlled study.” In Hepatology, 44:200A-201A. JOHN WILEY & SONS INC, 2006.
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    • Abdelmalek, Manal F., Paul Angulo, Roberta A. Jorgensenh, Pamela B. Sylvestre, and Keith D. Lindor. “Betaine for the treatment of nonalcoholic steatohepatitis: A promising new agent.” In Gastroenterology, 118:A973–A973. Elsevier BV, 2000. https://doi.org/10.1016/s0016-5085(00)86034-5.
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