Marc G. Caron
James B. Duke Distinguished Professor of Cell Biology
Studies of the mechanisms of action and regulation of hormones and neurotransmitters at the cellular and molecular levels constitute the main goals our of research activities. G protein-coupled receptors (GPCR) mediate the actions of signaling molecules from unicellular organisms to man. We have used adrenergic and dopamine receptors to characterize the structure/function and regulation mechanisms of these prototypes of G protein-coupled receptors. Another approach has been to characterize the nature of neurotransmitter transporters for dopamine, serotonin and other neurotransmitters in an attempt to understand their function in normal and pathological neurotransmission. Another goal of our laboratory is to define the genes and pathways involved in the reinforcing properties of drugs of abuse using both forward and reverse genetic approaches. Our laboratory uses biochemical, molecular biology and gene targeting approaches to examine these questions.
Current Appointments & Affiliations
- James B. Duke Distinguished Professor of Cell Biology, Cell Biology, Basic Science Departments 1998
- Professor of Cell Biology, Cell Biology, Basic Science Departments 1989
- Vice Chair for Science and Research in the Department of Cell Biology, Cell Biology, Basic Science Departments 2016
- Professor in Neurobiology, Neurobiology, Basic Science Departments 2006
- Professor in Medicine, Medicine, Cardiology, Medicine 2020
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1977
- Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2009
- Affiliate of the Regeneration Next Initiative, Regeneration Next Initiative, Institutes and Centers 2016
Contact Information
- CARL Building Room 487, Durham, NC 27710
- Duke Box 3287, Durham, NC 27710
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marc.caron@duke.edu
(919) 684-5433
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Department of Cell Biology
- Background
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Education, Training, & Certifications
- Ph.D., University of Miami 1973
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Duke Appointment History
- Professor in Medicine, Medicine, Cardiology, Medicine 2006 - 2020
- Research Professor in Medicine, Medicine, Cardiology, Medicine 1999 - 2006
- Research Professor in Medicine, Medicine, Clinical Science Departments 1994 - 1999
- Assistant Research Professor in Medicine, Medicine, Clinical Science Departments 1994
- Assistant Professor of Physiology, Immunology, Basic Science Departments 1983 - 1986
- Recognition
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In the News
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MAY 28, 2020 -
OCT 22, 2015 -
APR 22, 2015 -
FEB 9, 2015 -
NOV 11, 2013 Duke Research Blog
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Awards & Honors
- AAAS Fellow. American Association for the Advancement of Science. 2013
- MERIT Award. National Institutes of Health. 2010
- Julius Axelrod Award. American Society for Pharmacology and Experimental Therapeutics. 2005
- Highly Cited Researcher. Thomson Reuters. 2001
- Investigator/Alumni Investigator. Howard Hughes Medical Institute. 1992
- Research
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Selected Grants
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Functional and Mechanistic Dissection of GPCR Endosomal Signaling Dynamics awarded by National Institutes of Health 2021 - 2024
- Exploiting Biased Agonism at the Ghrelin Receptor (GHSR 1a) for Opioid Addiction awarded by National Institutes of Health 2020 - 2023
- Mechanistic studies of Mas receptor activation and its role in aortic aneurysm formation awarded by National Institutes of Health 2017 - 2022
- Duke Training Grant in Nephrology awarded by National Institutes of Health 1995 - 2022
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2022
- Secreted Factors for Zebrafish Spinal Cord Regeneration awarded by National Institutes of Health 2017 - 2022
- Managing L-DOPA Induced Dyskinesias by Targeting Dopamine D1 Receptor Biased Signaling awarded by Michael J. Fox Foundation for Parkinson's Research 2019 - 2022
- A novel functionally selective drug for the treatment of cocaine abuse by antagonism of the beta-arrestin signaling arm of the Ghrelin Receptor awarded by National Institutes of Health 2020 - 2021
- Development of SBI-553, an allosteric modulator of NTR1, for the treatment of substance use disorders awarded by Sanford Burnham Prebys Medical Discovery Institute 2019 - 2021
- A fully biological platform for monitoring mesoscale neural activity awarded by National Institutes of Health 2018 - 2021
- Translational Research in Surgical Oncology awarded by National Institutes of Health 2002 - 2021
- Super-resolution Imaging via Multiple Modalities with the Zeiss Elyra 7 awarded by National Institutes of Health 2020 - 2021
- Leveraging Functional Selectivity in the Neurotensin Receptor 1-Mediated Treatment of Addiction awarded by National Institutes of Health 2019 - 2021
- New Methods for Synthesis and Studies of Bioactive Nitrogen-Containing Molecules awarded by National Institutes of Health 2017 - 2020
- Establishing the molecular and cellular mechanisms of Lgr5 signaling for controlling cancer stem cell behavior awarded by National Institutes of Health 2017 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- How Does Huntingtin Control Synaptic Development? awarded by National Institutes of Health 2018 - 2020
- Unmasking a Role for Cortical Dopamine D4 Receptors in Controlling Circuit Dynamics and Behavior awarded by National Institutes of Health 2018 - 2020
- Akt/GSK-3 Signaling Cascade and the Actions of Dopamine awarded by National Institutes of Health 2005 - 2020
- Control of Excitatory Synapse Formation by Huntingtin awarded by National Institutes of Health 2017 - 2020
- Simultaneous and Bidirectional Chemogenetic Control of Mesolimbic and Nigrostriatal Circuits awarded by National Institutes of Health 2018 - 2020
- Pharmacology Industry Internships for Ph.D. Students awarded by American Society for Pharmacology and Experimental Therapeutics 2017 - 2019
- Biased Agonism at Neurotensin Receptor 1 for the Treatment of Methamphetamine Addiction awarded by National Institutes of Health 2017 - 2019
- Drug Abuse: Discovering Ligands for Pertinent GPCRs awarded by National Institutes of Health 2010 - 2019
- Basic predoctoral training in neuroscience awarded by National Institutes of Health 1992 - 2018
- Dissecting the Distinct Arrestin Signaling Capabilities of the Short and Long Dopamine D2 Receptors as a Paradigm for Psychostimulant Addiction Treatment awarded by National Institutes of Health 2016 - 2018
- Cellular and Molecular Signatures of Functionally-Selective D2R Ligands awarded by University of North Carolina - Chapel Hill 2012 - 2018
- A Cancer Rainbow Mouse for Simultaneous Assessment of Multiple Oncogenes awarded by National Institutes of Health 2015 - 2018
- The 5-HT theory of depression tested in a naturalistic model of 5-HT deficiency awarded by National Institutes of Health 2006 - 2017
- NARSAD Prize - Marc Caron / Nikhil Urs awarded by Brain and Behavior Research Foundation 2013 - 2016
- Screening and identification of beta-arrestin biased dopamine receptor ligands for PD symptom therapy. awarded by Michael J. Fox Foundation for Parkinson's Research 2016
- Chemical Biology Approaches to Combat Parkinson's Disease and Dyskinesia awarded by National Institutes of Health 2013 - 2016
- Ultra-resolution imaging of brain circuitry and its development in mental health awarded by National Institutes of Health 2013 - 2016
- Role of domaine D2 receptor biased signaling in antipsychotic responsive behaviours in genetically engineered mouse models awarded by Universite Laval 2015 - 2016
- Beta-arrestin Regulation of Ghrelin Signaling in Modulating Addictive Behavior awarded by National Institutes of Health 2014 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Validation of a novel mouse model of dyskinesia in Parkinson's disease awarded by Canadian Institutes of Health Research 2015 - 2016
- Training in Fundamental &Translational Neuroscience awarded by National Institutes of Health 2005 - 2016
- Consequences of naturalistic serotonin deficiency for suicide-related social endophenotypes in mice awarded by American Foundation for Suicide Prevention 2013 - 2015
- Deciphering Drug Abuse Induced Mechanisms of Cellular Plasticity awarded by Ruth K. Broad Biomedical Research Foundation 2014 - 2015
- Clinical Oncology Research Career Development Program awarded by National Institutes of Health 2009 - 2015
- Novel high-throughput screening for modifiers of TorsinA pathology awarded by National Institutes of Health 2013 - 2015
- A Cancer Rainbow Mouse for the Simultaneous Assessment of Multiple Oncogenes awarded by National Institutes of Health 2012 - 2015
- Whole brain multimodal microscopy of an apoptosis reporter mouse awarded by National Institutes of Health 2012 - 2014
- Negative regulation of NF-kB by optineurin in primary open angle glaucoma awarded by National Institutes of Health 2011 - 2014
- Discovering Ligands for a5-a3-b4 Nicotinic Acetylcholine Receptors. awarded by National Institutes of Health 2010 - 2014
- Non-invasive Chemical Genetic Control of Neuronal Activity awarded by National Institutes of Health 2009 - 2014
- The impact of serotonin deficiency on adult hippocampal neurogenesis, antidepressant-like responses, and stress vulnerability in mice awarded by National Institutes of Health 2011 - 2014
- Agilent Direct Drive 9.4T MRS/MRI Console awarded by National Institutes of Health 2012 - 2013
- Beta-catenin modulates dopamine dependent signal transduction and behavior. awarded by National Institutes of Health 2011 - 2013
- Role of beta-arrestin-2 signaling complexes in the actions of psychostimulants awarded by National Institutes of Health 2010 - 2013
- Small molecule screen to enhance epithelial repair awarded by National Institutes of Health 2011 - 2012
- Small Molecule Agonsists for the Neurotensin 1 Receptor awarded by National Institutes of Health 2009 - 2012
- IsoCyte Laser Scanning Plate Cytometer for High-throughput, High-content Assays awarded by National Institutes of Health 2011 - 2012
- Behavioral and Synaptic Consequences of MeCP2 Phosphorylation awarded by National Institutes of Health 2010 - 2011
- The Role of MafB in Mammalian Testis Morphogenesis awarded by National Institutes of Health 2008 - 2011
- Pharmacometabolomics Research Network awarded by National Institutes of Health 2010 - 2011
- Toxicant evaluation in mice with selective dopamine transporter overexpression awarded by National Institutes of Health 2008 - 2010
- Drug Abuse: Discovering Ligands for Pertinent GPCRs awarded by National Institutes of Health 2006 - 2010
- An ENU Mutagenesis Screen for Genes of Addiction awarded by National Institutes of Health 2006 - 2009
- Dopamine Receptor Regulation by GRKs in Drug Abuse awarded by National Institutes of Health 2004 - 2009
- Dopamine Receptors: Characterization And Regulation awarded by National Institutes of Health 1983 - 2008
- Elucidating the actions of acetylcholine in the brain awarded by National Institutes of Health 2005 - 2008
- Molecular studies of osmotic neural sensing awarded by National Institute of Mental Health 2002 - 2006
- Arrestins in G Protein-Coupled Receptor Trafficking awarded by National Institutes of Health 2003 - 2006
- Genetic Analysis of Dopaminergic Reward Mechanisms awarded by National Institutes of Health 2000 - 2006
- Molecular fingerprinting of GPCR ligands in Cancer awarded by National Institutes of Health 2004 - 2006
- GRK/Beta-arrestin in Sonic hedgehog signaling. awarded by National Institutes of Health 2004 - 2005
- Proteomic/Genetic Approaches to Monoamine Transporters awarded by National Institutes of Health 2003 - 2004
- Same awarded by National Institutes of Health 1999 - 2004
- Dopamine & Glutamate Pathways in Models of Schizophrenia awarded by National Institutes of Health 2000 - 2004
- Cell/Molecular Regulation of Human Dopamine Transporter awarded by National Institutes of Health 2001 - 2003
- Same awarded by National Institutes of Health 1997 - 2002
- Novel secretin receptor interacting proteins (Small Grant Program) awarded by National Institutes of Health 2001 - 2002
- Morphine Sensitivity in GRK and Arrestin Knockout Mice awarded by National Institutes of Health 2000 - 2002
- Presynaptic Dopamine Mechanisms After Chronic Cocaine awarded by National Institutes of Health 1997 - 1999
- Crc/Pe For The Study Of Depression awarded by National Institutes of Health 1984 - 1999
- Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Dopamine Receptors: Characterization And Regulation awarded by National Institutes of Health 1994 - 1998
- Dopamine Receptors: Characterization And Regulation awarded by National Institutes of Health 1991 - 1998
- Dopamine Receptors - Characterization And Regulation awarded by National Institutes of Health 1983 - 1998
- Pesticides And Dopaminergic Function awarded by National Institutes of Health 1997 - 1998
- Molecular Properties Of Cardiac Adrenergic Receptors awarded by National Institutes of Health 1976 - 1996
- An Investigation Of The Specificity Of Novel Ligans For Me awarded by National Institutes of Health 1993 - 1994
- Dopamine Receptors: Characterization & Endocrine Regula. awarded by National Institutes of Health 1990 - 1991
- Dopamine Receptors: Characterization & Endocrine Regulati. awarded by National Institutes of Health 1989 - 1991
- Dopamine Receptors: Characterization & Endocrine Regulatio awarded by National Institutes of Health 1988 - 1991
- Dopamine Receptors: Characterization And Endocrine Regulat awarded by National Institutes of Health 1987 - 1991
- Dopamine Receptors: Characterization/Endocrine Regulation awarded by National Institutes of Health 1985 - 1986
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External Relationships
- Evecxia Therapeutics (for-Profit, Non-Publicly-traded)
- Publications & Artistic Works
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Selected Publications
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Books
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Lefkowitz, R. J., C. Mukherjee, and M. Caron. Biochemical mechanisms for regulation of β adrenergic receptors by β adrenergic agonists. Vol. No. 402, 1977.
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Academic Articles
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Slosky, Lauren M., Marc G. Caron, and Lawrence S. Barak. “Biased Allosteric Modulators: New Frontiers in GPCR Drug Discovery.” Trends Pharmacol Sci 42, no. 4 (April 2021): 283–99. https://doi.org/10.1016/j.tips.2020.12.005.Full Text Link to Item
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Smith, Jeffrey S., Thomas F. Pack, Asuka Inoue, Claudia Lee, Kevin Zheng, Issac Choi, Dylan S. Eiger, et al. “Noncanonical scaffolding of Gαi and β-arrestin by G protein-coupled receptors.” Science 371, no. 6534 (March 12, 2021). https://doi.org/10.1126/science.aay1833.Full Text Link to Item
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Favier, Mathieu, Helena Janickova, Damian Justo, Ornela Kljakic, Léonie Runtz, Joman Y. Natsheh, Tharick A. Pascoal, et al. “Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating.” J Clin Invest 130, no. 12 (December 1, 2020): 6616–30. https://doi.org/10.1172/JCI138532.Full Text Link to Item
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Porter-Stransky, Kirsten A., Alyssa K. Petko, Saumya L. Karne, L Cameron Liles, Nikhil M. Urs, Marc G. Caron, Carlos A. Paladini, and David Weinshenker. “Loss of β-arrestin2 in D2 cells alters neuronal excitability in the nucleus accumbens and behavioral responses to psychostimulants and opioids.” Addict Biol 25, no. 6 (November 2020): e12823. https://doi.org/10.1111/adb.12823.Full Text Link to Item
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Slosky, Lauren M., Yushi Bai, Krisztian Toth, Caroline Ray, Lauren K. Rochelle, Alexandra Badea, Rahul Chandrasekhar, et al. “β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors.” Cell 181, no. 6 (June 11, 2020): 1364-1379.e14. https://doi.org/10.1016/j.cell.2020.04.053.Full Text Link to Item
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Li, Yan-Chun, Priyalakshmi Panikker, Bo Xing, Sha-Sha Yang, Cassandra Alexandropoulos, Erin P. McEachern, Rita Akumuo, et al. “Deletion of Glycogen Synthase Kinase-3β in D2 Receptor-Positive Neurons Ameliorates Cognitive Impairment via NMDA Receptor-Dependent Synaptic Plasticity.” Biol Psychiatry 87, no. 8 (April 15, 2020): 745–55. https://doi.org/10.1016/j.biopsych.2019.10.025.Full Text Link to Item
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Boone, Peter G., Lauren K. Rochelle, Joshua D. Ginzel, Veronica Lubkov, Wendy L. Roberts, P. J. Nicholls, Cheryl Bock, et al. “A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion.” Nat Commun 10, no. 1 (December 2, 2019): 5490. https://doi.org/10.1038/s41467-019-13330-y.Full Text Link to Item
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Jacobsen, Jacob P. R., Adrianna Oh, Rachel Bangle, Wendy L. Roberts, Elizabeth L. Royer, Nathan Modesto, Sonora A. Windermere, et al. “Slow-release delivery enhances the pharmacological properties of oral 5-hydroxytryptophan: mouse proof-of-concept.” Neuropsychopharmacology 44, no. 12 (November 2019): 2082–90. https://doi.org/10.1038/s41386-019-0400-1.Full Text Link to Item
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Martini, Michael L., Caroline Ray, Xufen Yu, Jing Liu, Vladimir M. Pogorelov, William C. Wetsel, Xi-Ping Huang, John D. McCorvy, Marc G. Caron, and Jian Jin. “Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity.” Acs Chem Neurosci 10, no. 9 (September 18, 2019): 4160–82. https://doi.org/10.1021/acschemneuro.9b00410.Full Text Link to Item
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Pinkerton, Anthony B., Satyamaheshwar Peddibhotla, Fusayo Yamamoto, Lauren M. Slosky, Yushi Bai, Patrick Maloney, Paul Hershberger, et al. “Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.” J Med Chem 62, no. 17 (September 12, 2019): 8357–63. https://doi.org/10.1021/acs.jmedchem.9b00340.Full Text Link to Item
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Toth, Krisztian, Karim Nagi, Lauren M. Slosky, Lauren Rochelle, Caroline Ray, Suneet Kaur, Sudha K. Shenoy, Marc G. Caron, and Larry S. Barak. “Encoding the β-Arrestin Trafficking Fate of Ghrelin Receptor GHSR1a: C-Tail-Independent Molecular Determinants in GPCRs.” Acs Pharmacol Transl Sci 2, no. 4 (August 9, 2019): 230–46. https://doi.org/10.1021/acsptsci.9b00018.Full Text Link to Item
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Israelyan, Narek, Andrew Del Colle, Zhishan Li, Yeji Park, Albert Xing, Jacob P. R. Jacobsen, Ruth Ann Luna, et al. “Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.” Gastroenterology 157, no. 2 (August 2019): 507-521.e4. https://doi.org/10.1053/j.gastro.2019.04.022.Full Text Link to Item
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Pydi, Sai P., Shanu Jain, Wesley Tung, Yinghong Cui, Lu Zhu, Wataru Sakamoto, Shalini Jain, et al. “Adipocyte β-arrestin-2 is essential for maintaining whole body glucose and energy homeostasis.” Nat Commun 10, no. 1 (July 3, 2019): 2936. https://doi.org/10.1038/s41467-019-11003-4.Full Text Link to Item
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Martini, Michael L., Jing Liu, Caroline Ray, Xufen Yu, Xi-Ping Huang, Aarti Urs, Nikhil Urs, et al. “Defining Structure-Functional Selectivity Relationships (SFSR) for a Class of Non-Catechol Dopamine D1 Receptor Agonists.” J Med Chem 62, no. 7 (April 11, 2019): 3753–72. https://doi.org/10.1021/acs.jmedchem.9b00351.Full Text Link to Item
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Mackie, Duncan I., Fuad Al Mutairi, Reema B. Davis, Daniel O. Kechele, Natalie R. Nielsen, Joshua C. Snyder, Marc G. Caron, et al. “hCALCRL mutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia.” J Exp Med 215, no. 9 (September 3, 2018): 2339–53. https://doi.org/10.1084/jem.20180528.Full Text Link to Item
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Pack, Thomas F., Margo I. Orlen, Caroline Ray, Sean M. Peterson, and Marc G. Caron. “The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation.” J Biol Chem 293, no. 16 (April 20, 2018): 6161–71. https://doi.org/10.1074/jbc.RA117.001300.Full Text Link to Item
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Beraldo, Flavio H., Valeriy G. Ostapchenko, Jason Z. Xu, Gianni M. Di Guglielmo, Jue Fan, Peter J. Nicholls, Marc G. Caron, Vania F. Prado, and Marco A. M. Prado. “Mechanisms of neuroprotection against ischemic insult by stress-inducible phosphoprotein-1/prion protein complex.” J Neurochem 145, no. 1 (April 2018): 68–79. https://doi.org/10.1111/jnc.14281.Full Text Link to Item
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Rose, Samuel J., Thomas F. Pack, Sean M. Peterson, Kaitlin Payne, Emiliana Borrelli, and Marc G. Caron. “Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions.” Neuropsychopharmacology 43, no. 5 (April 2018): 1164–73. https://doi.org/10.1038/npp.2017.254.Full Text Link to Item
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Hultman, Rainbo, Kyle Ulrich, Benjamin D. Sachs, Cameron Blount, David E. Carlson, Nkemdilim Ndubuizu, Rosemary C. Bagot, et al. “Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability.” Cell 173, no. 1 (March 22, 2018): 166-180.e14. https://doi.org/10.1016/j.cell.2018.02.012.Full Text Link to Item
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Sachs, Benjamin D., Ha L. Tran, Emily Folse, and Marc G. Caron. “Brain-region-specific Molecular Responses to Maternal Separation and Social Defeat Stress in Mice.” Neuroscience 373 (March 1, 2018): 122–36. https://doi.org/10.1016/j.neuroscience.2018.01.018.Full Text Link to Item
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Toth, Krisztian, Lauren M. Slosky, Thomas F. Pack, Nikhil M. Urs, Peter Boone, Lan Mao, Dennis Abraham, Marc G. Caron, and Lawrence S. Barak. “Ghrelin receptor antagonism of hyperlocomotion in cocaine-sensitized mice requires βarrestin-2.” Synapse 72, no. 1 (January 2018). https://doi.org/10.1002/syn.22012.Full Text Link to Item
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Fakhouri, Lara, Christopher D. Cook, Mohammed H. Al-Huniti, Linda M. Console-Bram, Dow P. Hurst, Michael B. S. Spano, Daniel J. Nasrallah, et al. “Design, synthesis and biological evaluation of GPR55 agonists.” Bioorg Med Chem 25, no. 16 (August 15, 2017): 4355–67. https://doi.org/10.1016/j.bmc.2017.06.016.Full Text Link to Item
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Zhu, Lu, Mario Rossi, Yinghong Cui, Regina J. Lee, Wataru Sakamoto, Nicole A. Perry, Nikhil M. Urs, et al. “Hepatic β-arrestin 2 is essential for maintaining euglycemia.” J Clin Invest 127, no. 8 (August 1, 2017): 2941–45. https://doi.org/10.1172/JCI92913.Full Text Link to Item
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Le Gonidec, Sophie, Carline Chaves-Almagro, Yushi Bai, Hye Jin Kang, Allyson Smith, Estelle Wanecq, Xi-Ping Huang, et al. “Protamine is an antagonist of apelin receptor, and its activity is reversed by heparin.” Faseb J 31, no. 6 (June 2017): 2507–19. https://doi.org/10.1096/fj.201601074R.Full Text Link to Item
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Snyder, Joshua C., Lauren K. Rochelle, Caroline Ray, Thomas F. Pack, Cheryl B. Bock, Veronica Lubkov, H Kim Lyerly, Alan S. Waggoner, Larry S. Barak, and Marc G. Caron. “Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness.” J Biol Chem 292, no. 17 (April 28, 2017): 7208–22. https://doi.org/10.1074/jbc.M116.756635.Full Text Link to Item
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Ray, Caroline, Erik J. Soderblom, Yushi Bai, F Ivy Carroll, Marc G. Caron, and Larry S. Barak. “Probing the Allosteric Role of the α5 Subunit of α3β4α5 Nicotinic Acetylcholine Receptors by Functionally Selective Modulators and Ligands.” Acs Chem Biol 12, no. 3 (March 17, 2017): 702–14. https://doi.org/10.1021/acschembio.6b01117.Full Text Link to Item
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Zhu, Lu, Joana Almaça, Prasanna K. Dadi, Hao Hong, Wataru Sakamoto, Mario Rossi, Regina J. Lee, et al. “β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and pathophysiological conditions.” Nat Commun 8 (February 1, 2017): 14295. https://doi.org/10.1038/ncomms14295.Full Text Link to Item
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Urs, Nikhil M., Sean M. Peterson, and Marc G. Caron. “New Concepts in Dopamine D2 Receptor Biased Signaling and Implications for Schizophrenia Therapy.” Biol Psychiatry 81, no. 1 (January 1, 2017): 78–85. https://doi.org/10.1016/j.biopsych.2016.10.011.Full Text Link to Item
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Urs, Nikhil M., Steven M. Gee, Thomas F. Pack, John D. McCorvy, Tama Evron, Joshua C. Snyder, Xiaobao Yang, et al. “Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.” Proc Natl Acad Sci U S A 113, no. 50 (December 13, 2016): E8178–86. https://doi.org/10.1073/pnas.1614347113.Full Text Link to Item
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Jacobsen, Jacob P. R., Andrew D. Krystal, K Ranga R. Krishnan, and Marc G. Caron. “Adjunctive 5-Hydroxytryptophan Slow-Release for Treatment-Resistant Depression: Clinical and Preclinical Rationale.” Trends Pharmacol Sci 37, no. 11 (November 2016): 933–44. https://doi.org/10.1016/j.tips.2016.09.001.Full Text Link to Item
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Jacobsen, Jacob Pr, Meghan L. Rudder, Wendy Roberts, Elizabeth L. Royer, Taylor J. Robinson, Adrianna Oh, Ivan Spasojevic, Benjamin D. Sachs, and Marc G. Caron. “SSRI Augmentation by 5-Hydroxytryptophan Slow Release: Mouse Pharmacodynamic Proof of Concept.” Neuropsychopharmacology 41, no. 9 (August 2016): 2324–34. https://doi.org/10.1038/npp.2016.35.Full Text Link to Item
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Barak, Larry S., Yushi Bai, Sean Peterson, Tama Evron, Nikhil M. Urs, Satyamaheshwar Peddibhotla, Michael P. Hedrick, et al. “ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.” Acs Chem Biol 11, no. 7 (July 15, 2016): 1880–90. https://doi.org/10.1021/acschembio.6b00291.Full Text Link to Item
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Caron, Marc G., and Ulrik Gether. “Structural biology: Antidepressants at work.” Nature 532, no. 7599 (April 21, 2016): 320–21. https://doi.org/10.1038/nature17883.Full Text Link to Item
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Meza-Aviña, Maria Elena, Mary A. Lingerfelt, Linda M. Console-Bram, Thomas F. Gamage, Haleli Sharir, Kristen E. Gettys, Dow P. Hurst, et al. “Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones.” Bioorg Med Chem Lett 26, no. 7 (April 1, 2016): 1827–30. https://doi.org/10.1016/j.bmcl.2016.02.030.Full Text Link to Item
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Park, Su M., Meng Chen, Claire M. Schmerberg, Russell S. Dulman, Ramona M. Rodriguiz, Marc G. Caron, Jian Jin, and William C. Wetsel. “Effects of β-Arrestin-Biased Dopamine D2 Receptor Ligands on Schizophrenia-Like Behavior in Hypoglutamatergic Mice.” Neuropsychopharmacology 41, no. 3 (February 2016): 704–15. https://doi.org/10.1038/npp.2015.196.Full Text Link to Item
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Snyder, Joshua C., Thomas F. Pack, Lauren K. Rochelle, Subhasish K. Chakraborty, Ming Zhang, Andrew W. Eaton, Yushi Bai, et al. “A rapid and affordable screening platform for membrane protein trafficking.” Bmc Biol 13 (December 17, 2015): 107. https://doi.org/10.1186/s12915-015-0216-3.Full Text Link to Item
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Sutton, Laurie P., and Marc G. Caron. “Essential role of D1R in the regulation of mTOR complex1 signaling induced by cocaine.” Neuropharmacology 99 (December 2015): 610–19. https://doi.org/10.1016/j.neuropharm.2015.08.024.Full Text Link to Item
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Sidor, M. M., S. M. Spencer, K. Dzirasa, P. K. Parekh, K. M. Tye, M. R. Warden, R. N. Arey, et al. “Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.” Mol Psychiatry 20, no. 11 (November 2015): 1406–19. https://doi.org/10.1038/mp.2014.167.Full Text Link to Item
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Sidor, M. M., S. M. Spencer, K. Dzirasa, P. K. Parekh, K. M. Tye, M. R. Warden, R. N. Arey, et al. “Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice.” Mol Psychiatry 20, no. 11 (November 2015): 1479–80. https://doi.org/10.1038/mp.2015.8.Full Text Link to Item
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Peterson, Sean M., Thomas F. Pack, Angela D. Wilkins, Nikhil M. Urs, Daniel J. Urban, Caroline E. Bass, Olivier Lichtarge, and Marc G. Caron. “Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor.” Proc Natl Acad Sci U S A 112, no. 22 (June 2, 2015): 7097–7102. https://doi.org/10.1073/pnas.1502742112.Full Text Link to Item
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Urs, Nikhil M., Simone Bido, Sean M. Peterson, Tanya L. Daigle, Caroline E. Bass, Raul R. Gainetdinov, Erwan Bezard, and Marc G. Caron. “Targeting β-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease.” Proc Natl Acad Sci U S A 112, no. 19 (May 12, 2015): E2517–26. https://doi.org/10.1073/pnas.1502740112.Full Text Link to Item
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Snyder, Joshua C., Lauren K. Rochelle, Sébastien Marion, H Kim Lyerly, Larry S. Barak, and Marc G. Caron. “Lgr4 and Lgr5 drive the formation of long actin-rich cytoneme-like membrane protrusions.” J Cell Sci 128, no. 6 (March 15, 2015): 1230–40. https://doi.org/10.1242/jcs.166322.Full Text Link to Item
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Sachs, Benjamin D., Ramona M. Rodriguiz, Ha L. Tran, Akshita Iyer, William C. Wetsel, and Marc G. Caron. “Serotonin deficiency alters susceptibility to the long-term consequences of adverse early life experience.” Psychoneuroendocrinology 53 (March 2015): 69–81. https://doi.org/10.1016/j.psyneuen.2014.12.019.Full Text Link to Item
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Sachs, Benjamin D., Jason R. Ni, and Marc G. Caron. “Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress.” Proc Natl Acad Sci U S A 112, no. 8 (February 24, 2015): 2557–62. https://doi.org/10.1073/pnas.1416866112.Full Text Link to Item
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Gao, Y., S. Peterson, B. Masri, M. T. Hougland, N. Adham, I. Gyertyán, B. Kiss, M. G. Caron, and R. S. El-Mallakh. “Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β-arrestin interactions.” Pharmacology Research and Perspectives 3, no. 1 (February 1, 2015): 1–10. https://doi.org/10.1002/prp2.73.Full Text
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Masoud, S. T., L. M. Vecchio, Y. Bergeron, M. M. Hossain, L. T. Nguyen, M. K. Bermejo, B. Kile, et al. “Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.” Neurobiol Dis 74 (February 2015): 66–75. https://doi.org/10.1016/j.nbd.2014.10.016.Full Text Link to Item
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Burczyk, Martina, Martin D. Burkhalter, Tamara Blätte, Sabrina Matysik, Marc G. Caron, Lawrence S. Barak, and Melanie Philipp. “Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2.” Biochemistry 54, no. 3 (January 27, 2015): 765–75. https://doi.org/10.1021/bi501061h.Full Text Link to Item
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Peterson, Sean M., Thomas F. Pack, and Marc G. Caron. “Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity.” Plos One 10, no. 10 (2015): e0141637. https://doi.org/10.1371/journal.pone.0141637.Full Text Link to Item
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Jacobsen, Jacob P. R., Per Plenge, Benjamin D. Sachs, Alan L. Pehrson, Manuel Cajina, Yunzhi Du, Wendy Roberts, et al. “The interaction of escitalopram and R-citalopram at the human serotonin transporter investigated in the mouse.” Psychopharmacology (Berl) 231, no. 23 (December 2014): 4527–40. https://doi.org/10.1007/s00213-014-3595-1.Full Text Link to Item
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Evron, Tama, Sean M. Peterson, Nikhil M. Urs, Yushi Bai, Lauren K. Rochelle, Marc G. Caron, and Larry S. Barak. “G Protein and β-arrestin signaling bias at the ghrelin receptor.” J Biol Chem 289, no. 48 (November 28, 2014): 33442–55. https://doi.org/10.1074/jbc.M114.581397.Full Text Link to Item
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Sachs, Benjamin D., and Marc G. Caron. “Chronic fluoxetine increases extra-hippocampal neurogenesis in adult mice.” Int J Neuropsychopharmacol 18, no. 4 (October 31, 2014). https://doi.org/10.1093/ijnp/pyu029.Full Text Link to Item
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Philipp, Melanie, Ina M. Berger, Steffen Just, and Marc G. Caron. “Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development.” J Biol Chem 289, no. 38 (September 19, 2014): 26119–30. https://doi.org/10.1074/jbc.M114.551952.Full Text Link to Item
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Daigle, Tanya L., Mark J. Ferris, Raul R. Gainetdinov, Tatyana D. Sotnikova, Nikhil M. Urs, Sara R. Jones, and Marc G. Caron. “Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmission.” Neuropsychopharmacology 39, no. 10 (September 2014): 2450–62. https://doi.org/10.1038/npp.2014.97.Full Text Link to Item
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Wang, Chong, Huixian Wu, Tama Evron, Eyal Vardy, Gye Won Han, Xi-Ping Huang, Sandy J. Hufeisen, et al. “Structural basis for Smoothened receptor modulation and chemoresistance to anticancer drugs.” Nat Commun 5 (July 10, 2014): 4355. https://doi.org/10.1038/ncomms5355.Full Text Link to Item
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Urs, N. M., and M. G. Caron. “The physiological relevance of functional selectivity in dopamine signalling.” Int J Obes Suppl 4, no. Suppl 1 (July 2014): S5–8. https://doi.org/10.1038/ijosup.2014.3.Full Text Link to Item
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Marion, Sébastien, Nikhil M. Urs, Sean M. Peterson, Tatyana D. Sotnikova, Jean-Martin Beaulieu, Raul R. Gainetdinov, and Marc G. Caron. “Dopamine D2 receptor relies upon PPM/PP2C protein phosphatases to dephosphorylate huntingtin protein.” J Biol Chem 289, no. 17 (April 25, 2014): 11715–24. https://doi.org/10.1074/jbc.M113.544312.Full Text Link to Item
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Urs, Nikhil M., Peter J. Nicholls, and Marc G. Caron. “Integrated approaches to understanding antipsychotic drug action at GPCRs.” Curr Opin Cell Biol 27 (April 2014): 56–62. https://doi.org/10.1016/j.ceb.2013.11.002.Full Text Link to Item
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Sachs, Benjamin D., A Ayten Salahi, and Marc G. Caron. “Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice.” Neuropharmacology 77 (February 2014): 177–84. https://doi.org/10.1016/j.neuropharm.2013.09.010.Full Text Link to Item
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Sachs, Benjamin D., Jason R. Ni, and Marc G. Caron. “Sex differences in response to chronic mild stress and congenital serotonin deficiency.” Psychoneuroendocrinology 40 (February 2014): 123–29. https://doi.org/10.1016/j.psyneuen.2013.11.008.Full Text Link to Item
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Hershberger, Paul M., Michael P. Hedrick, Satyamaheshwar Peddibhotla, Arianna Mangravita-Novo, Palak Gosalia, Yujie Li, Wilson Gray, et al. “Imidazole-derived agonists for the neurotensin 1 receptor.” Bioorg Med Chem Lett 24, no. 1 (January 1, 2014): 262–67. https://doi.org/10.1016/j.bmcl.2013.11.026.Full Text Link to Item
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Snyder, J. C., L. K. Rochelle, L. S. Barak, and M. G. Caron. “Correction: The Stem Cell-Expressed Receptor Lgr5 Possesses Canonical and Functionally Active Molecular Determinants Critical to β-arrestin-2 Recruitment.” Plos One 9, no. 1 (2014). https://doi.org/10.1371/annotation/7f83735d-53d4-42f3-b3b2-b05dd5db059c.Full Text Link to Item
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Kotsikorou, Evangelia, Haleli Sharir, Derek M. Shore, Dow P. Hurst, Diane L. Lynch, Karla E. Madrigal, Susanne Heynen-Genel, et al. “Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.” Biochemistry 52, no. 52 (December 31, 2013): 9456–69. https://doi.org/10.1021/bi4008885.Full Text Link to Item
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Gregory, K. J., E. J. Herman, A. J. Ramsey, A. S. Hammond, N. E. Byun, S. R. Stauffer, J. T. Manka, et al. “N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy in preclinical models of NMDA hypofunction and cognitive enhancement.” J Pharmacol Exp Ther 347, no. 2 (November 2013): 438–57. https://doi.org/10.1124/jpet.113.206623.Full Text Link to Item
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Min, C., M. Zheng, X. Zhang, M. G. Caron, and K. M. Kim. “Novel roles for β-arrestins in the regulation of pharmacological sequestration to predict agonist-induced desensitization of dopamine D3 receptors.” Br J Pharmacol 170, no. 5 (November 2013): 1112–29. https://doi.org/10.1111/bph.12357.Full Text Link to Item
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Jørgensen, Christinna V., Jacob P. Jacobsen, Marc G. Caron, Anders B. Klein, Gitte M. Knudsen, and Jens D. Mikkelsen. “Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase 2 decrease-of-function mice.” Neurosci Lett 555 (October 25, 2013): 118–22. https://doi.org/10.1016/j.neulet.2013.08.073.Full Text Link to Item
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Sachs, Benjamin D., Ramona M. Rodriguiz, William B. Siesser, Alexander Kenan, Elizabeth L. Royer, Jacob P. R. Jacobsen, William C. Wetsel, and Marc G. Caron. “The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress.” Int J Neuropsychopharmacol 16, no. 9 (October 2013): 2081–94. https://doi.org/10.1017/S1461145713000321.Full Text Link to Item
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Burkhalter, Martin D., Gregory B. Fralish, Richard T. Premont, Marc G. Caron, and Melanie Philipp. “Grk5l controls heart development by limiting mTOR signaling during symmetry breaking.” Cell Rep 4, no. 4 (August 29, 2013): 625–32. https://doi.org/10.1016/j.celrep.2013.07.036.Full Text Link to Item
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Barak, Larry S., Yushi Bai, Joshua C. Snyder, Jiangbo Wang, Wei Chen, and Marc G. Caron. “Triphenylmethane dye activation of beta-arrestin.” Biochemistry 52, no. 32 (August 13, 2013): 5403–14. https://doi.org/10.1021/bi400217r.Full Text Link to Item
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Sachs, B. D., J. P. R. Jacobsen, T. L. Thomas, W. B. Siesser, W. L. Roberts, and M. G. Caron. “The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine.” Transl Psychiatry 3 (August 13, 2013): e291. https://doi.org/10.1038/tp.2013.65.Full Text Link to Item
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Peddibhotla, Satyamaheshwar, Michael P. Hedrick, Paul Hershberger, Patrick R. Maloney, Yujie Li, Monika Milewski, Palak Gosalia, et al. “Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.” Acs Med Chem Lett 4, no. 9 (July 20, 2013): 846–51. https://doi.org/10.1021/ml400176n.Full Text Link to Item
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Thakur, Ganesh A., Shama Bajaj, Carol Paronis, Yan Peng, Anna L. Bowman, Lawrence S. Barak, Marc G. Caron, Demon Parrish, Jeffrey R. Deschamps, and Alexandros Makriyannis. “Novel adamantyl cannabinoids as CB1 receptor probes.” J Med Chem 56, no. 10 (May 23, 2013): 3904–21. https://doi.org/10.1021/jm4000775.Full Text Link to Item
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Snyder, Joshua C., Lauren K. Rochelle, H Kim Lyerly, Marc G. Caron, and Lawrence S. Barak. “Constitutive internalization of the leucine-rich G protein-coupled receptor-5 (LGR5) to the trans-Golgi network.” J Biol Chem 288, no. 15 (April 12, 2013): 10286–97. https://doi.org/10.1074/jbc.M112.447540.Full Text Link to Item
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Farrell, Martilias S., Ying Pei, Yehong Wan, Prem N. Yadav, Tanya L. Daigle, Daniel J. Urban, Hyeong-Min Lee, et al. “A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons.” Neuropsychopharmacology 38, no. 5 (April 2013): 854–62. https://doi.org/10.1038/npp.2012.251.Full Text Link to Item
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Dzirasa, Kafui, Sunil Kumar, Benjamin D. Sachs, Marc G. Caron, and Miguel A. L. Nicolelis. “Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency.” J Neurosci 33, no. 10 (March 6, 2013): 4505–13. https://doi.org/10.1523/JNEUROSCI.4891-12.2013.Full Text Link to Item
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Siesser, William B., Benjamin D. Sachs, Amy J. Ramsey, Tatyana D. Sotnikova, Jean-Martin Beaulieu, Xiaodong Zhang, Marc G. Caron, and Raul R. Gainetdinov. “Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice.” Acs Chem Neurosci 4, no. 1 (January 16, 2013): 84–88. https://doi.org/10.1021/cn300127h.Full Text Link to Item
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Hara, Makoto R., Benjamin D. Sachs, Marc G. Caron, and Robert J. Lefkowitz. “Pharmacological blockade of a β(2)AR-β-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model.” Cell Cycle 12, no. 2 (January 15, 2013): 219–24. https://doi.org/10.4161/cc.23368.Full Text Link to Item
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Calipari, Erin S., Mark J. Ferris, Ali Salahpour, Marc G. Caron, and Sara R. Jones. “Methylphenidate amplifies the potency and reinforcing effects of amphetamines by increasing dopamine transporter expression.” Nat Commun 4 (2013): 2720. https://doi.org/10.1038/ncomms3720.Full Text Link to Item
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Caron, M. G., N. M. Urs, J. C. Snyder, and S. M. Peterson. “Integrated Approaches to Understand the Actions of GPCRs: The b-Arrestin-Dependent D2R Mediated Signaling Through Akt/GSK3,” January 1, 2013, 99–100. https://doi.org/10.1016/B978-0-12-800044-1.00086-6.Full Text
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Evron, T., N. M. Urs, L. Sutton, Y. Bai, M. G. Caron, and L. S. Barak. “β-arrestin Regulation of Ghrelin Signaling in modulating Addictive Behavior,” January 1, 2013, 184. https://doi.org/10.1016/B978-0-12-800044-1.00167-7.Full Text
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Philipp, Melanie, Tama Evron, and Marc G. Caron. “The role of arrestins in development.” Prog Mol Biol Transl Sci 118 (2013): 225–42. https://doi.org/10.1016/B978-0-12-394440-5.00009-7.Full Text Link to Item
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Sassano, M. F., J. A. Allen, J. Jin, V. Setola, W. C. Wetsel, M. G. Caron, and B. L. Roth. “D2 Functionally Selective Ligands: Novel Therapeutics?,” January 1, 2013, 105. https://doi.org/10.1016/B978-0-12-800044-1.00091-X.Full Text
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Snyder, Joshua C., Lauren K. Rochelle, Larry S. Barak, and Marc G. Caron. “The stem cell-expressed receptor Lgr5 possesses canonical and functionally active molecular determinants critical to β-arrestin-2 recruitment.” Plos One 8, no. 12 (2013): e84476. https://doi.org/10.1371/journal.pone.0084476.Full Text Link to Item
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Urs, N. M., T. L. Daigle, J. Ting, and M. G. Caron. “Targeting Beta-Arrestin Dependent Signaling in the Treatment of Parkinson's Disease,” January 1, 2013, 103–4. https://doi.org/10.1016/B978-0-12-800044-1.00090-8.Full Text
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Urs, Nikhil M., Joshua C. Snyder, Jacob P. R. Jacobsen, Sean M. Peterson, and Marc G. Caron. “Deletion of GSK3β in D2R-expressing neurons reveals distinct roles for β-arrestin signaling in antipsychotic and lithium action.” Proc Natl Acad Sci U S A 109, no. 50 (December 11, 2012): 20732–37. https://doi.org/10.1073/pnas.1215489109.Full Text Link to Item
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Peterson, S. M., N. Urs, and M. G. Caron. “Dopamine Receptors,” December 1, 2012, 67–70. https://doi.org/10.1016/B978-0-12-386525-0.00013-5.Full Text
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Revel, Florent G., Jean-Luc Moreau, Raul R. Gainetdinov, Antonio Ferragud, Clara Velázquez-Sánchez, Tatyana D. Sotnikova, Stephen R. Morairty, et al. “Trace amine-associated receptor 1 partial agonism reveals novel paradigm for neuropsychiatric therapeutics.” Biol Psychiatry 72, no. 11 (December 1, 2012): 934–42. https://doi.org/10.1016/j.biopsych.2012.05.014.Full Text Link to Item
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Jacobsen, Jacob P. R., Ivan O. Medvedev, and Marc G. Caron. “The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse.” Philos Trans R Soc Lond B Biol Sci 367, no. 1601 (September 5, 2012): 2444–59. https://doi.org/10.1098/rstb.2012.0109.Full Text Link to Item
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Daigle, Tanya L., and Marc G. Caron. “Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation.” J Neurosci 32, no. 33 (August 15, 2012): 11461–66. https://doi.org/10.1523/JNEUROSCI.2234-12.2012.Full Text Link to Item
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Jacobsen, J. P. R., W. B. Siesser, B. D. Sachs, S. Peterson, M. J. Cools, V. Setola, J. H. A. Folgering, G. Flik, and M. G. Caron. “Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice.” Mol Psychiatry 17, no. 7 (July 2012): 694–704. https://doi.org/10.1038/mp.2011.50.Full Text Link to Item
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Anzalone, Andrea, José E. Lizardi-Ortiz, Maria Ramos, Claudia De Mei, F Woodward Hopf, Ciro Iaccarino, Briac Halbout, et al. “Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors.” J Neurosci 32, no. 26 (June 27, 2012): 9023–34. https://doi.org/10.1523/JNEUROSCI.0918-12.2012.Full Text Link to Item
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Kile, Brian M., Paul L. Walsh, Zoé A. McElligott, Elizabeth S. Bucher, Thomas S. Guillot, Ali Salahpour, Marc G. Caron, and R Mark Wightman. “Optimizing the Temporal Resolution of Fast-Scan Cyclic Voltammetry.” Acs Chem Neurosci 3, no. 4 (April 18, 2012): 285–92. https://doi.org/10.1021/cn200119u.Full Text Link to Item
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Frankowski, Kevin J., Michael P. Hedrick, Palak Gosalia, Kelin Li, Shenghua Shi, David Whipple, Partha Ghosh, et al. “Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.” Acs Chem Neurosci 3, no. 3 (March 21, 2012): 221–36. https://doi.org/10.1021/cn200128x.Full Text Link to Item
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Evron, Tama, Tanya L. Daigle, and Marc G. Caron. “GRK2: multiple roles beyond G protein-coupled receptor desensitization.” Trends Pharmacol Sci 33, no. 3 (March 2012): 154–64. https://doi.org/10.1016/j.tips.2011.12.003.Full Text Link to Item
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Meck, Warren H., Ruey-Kuang Cheng, Christopher J. MacDonald, Raul R. Gainetdinov, Marc G. Caron, and Münire Özlem Cevik. “Gene-dose dependent effects of methamphetamine on interval timing in dopamine-transporter knockout mice.” Neuropharmacology 62, no. 3 (March 2012): 1221–29. https://doi.org/10.1016/j.neuropharm.2011.01.042.Full Text Link to Item
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Zhong, Huailing, Connie Sánchez, and Marc G. Caron. “Consideration of allosterism and interacting proteins in the physiological functions of the serotonin transporter.” Biochem Pharmacol 83, no. 4 (February 15, 2012): 435–42. https://doi.org/10.1016/j.bcp.2011.09.020.Full Text Link to Item
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Salahpour, Ali, and Marc G. Caron. “Food for thought: the physiological relevance of ghrelin and dopamine D2 receptor heterodimerization in the regulation of appetite.” Neuron 73, no. 2 (January 26, 2012): 210–11. https://doi.org/10.1016/j.neuron.2012.01.004.Full Text Link to Item
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Managò, Francesca, Stefano Espinoza, Ali Salahpour, Tatyana D. Sotnikova, Marc G. Caron, Richard T. Premont, and Raul R. Gainetdinov. “The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment.” Sci Rep 2 (2012): 301. https://doi.org/10.1038/srep00301.Full Text Open Access Copy Link to Item
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Wong, Peiyan, Cecilia Chin Roei Chang, Christine E. Marx, Marc G. Caron, William C. Wetsel, and Xiaodong Zhang. “Pregnenolone rescues schizophrenia-like behavior in dopamine transporter knockout mice.” Plos One 7, no. 12 (2012): e51455. https://doi.org/10.1371/journal.pone.0051455.Full Text Link to Item
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Zhang, X., P. J. Nicholls, G. Laje, T. D. Sotnikova, R. R. Gainetdinov, P. R. Albert, G. Rajkowska, et al. “A functional alternative splicing mutation in human tryptophan hydroxylase-2.” Mol Psychiatry 16, no. 12 (December 2011): 1169–76. https://doi.org/10.1038/mp.2010.99.Full Text Link to Item
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Allen, John A., Julianne M. Yost, Vincent Setola, Xin Chen, Maria F. Sassano, Meng Chen, Sean Peterson, et al. “Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.” Proc Natl Acad Sci U S A 108, no. 45 (November 8, 2011): 18488–93. https://doi.org/10.1073/pnas.1104807108.Full Text Link to Item
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Daigle, Tanya L., William C. Wetsel, and Marc G. Caron. “Opposite function of dopamine D1 and N-methyl-D-aspartate receptors in striatal cannabinoid-mediated signaling.” Eur J Neurosci 34, no. 9 (November 2011): 1378–89. https://doi.org/10.1111/j.1460-9568.2011.07874.x.Full Text Link to Item
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Guzman, Monica S., Xavier De Jaeger, Sanda Raulic, Ivana A. Souza, Alex X. Li, Susanne Schmid, Ravi S. Menon, et al. “Elimination of the vesicular acetylcholine transporter in the striatum reveals regulation of behaviour by cholinergic-glutamatergic co-transmission.” Plos Biol 9, no. 11 (November 2011): e1001194. https://doi.org/10.1371/journal.pbio.1001194.Full Text Link to Item
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Herrmann, Rolf, Stephanie J. Heflin, Timothy Hammond, Bowa Lee, Jing Wang, Raul R. Gainetdinov, Marc G. Caron, et al. “Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA.” Neuron 72, no. 1 (October 6, 2011): 101–10. https://doi.org/10.1016/j.neuron.2011.07.030.Full Text Link to Item
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Marder, Stephen R., Bryan Roth, Patrick F. Sullivan, Edward M. Scolnick, Eric J. Nestler, Mark A. Geyer, Daniel R. Welnberger, et al. “Advancing drug discovery for schizophrenia.” Ann N Y Acad Sci 1236 (October 2011): 30–43. https://doi.org/10.1111/j.1749-6632.2011.06216.x.Full Text Link to Item
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Espinoza, Stefano, Ali Salahpour, Bernard Masri, Tatyana D. Sotnikova, Mirko Messa, Larry S. Barak, Marc G. Caron, and Raul R. Gainetdinov. “Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor.” Mol Pharmacol 80, no. 3 (September 2011): 416–25. https://doi.org/10.1124/mol.111.073304.Full Text Link to Item
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Evron, Tama, Melanie Philipp, Jiuyi Lu, Alison R. Meloni, Martin Burkhalter, Wei Chen, and Marc G. Caron. “Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling.” J Biol Chem 286, no. 31 (August 5, 2011): 27676–86. https://doi.org/10.1074/jbc.M111.234666.Full Text Link to Item
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Revel, Florent G., Jean-Luc Moreau, Raul R. Gainetdinov, Amyaouch Bradaia, Tatyana D. Sotnikova, Roland Mory, Sean Durkin, et al. “TAAR1 activation modulates monoaminergic neurotransmission, preventing hyperdopaminergic and hypoglutamatergic activity.” Proc Natl Acad Sci U S A 108, no. 20 (May 17, 2011): 8485–90. https://doi.org/10.1073/pnas.1103029108.Full Text Link to Item
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Berlanga, M. L., D. L. Price, B. S. Phung, R. Giuly, M. Terada, N. Yamada, M. Cyr, et al. “Multiscale imaging characterization of dopamine transporter knockout mice reveals regional alterations in spine density of medium spiny neurons.” Brain Res 1390 (May 16, 2011): 41–49. https://doi.org/10.1016/j.brainres.2011.03.044.Full Text Link to Item
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Soderblom, Erik J., Melanie Philipp, J Will Thompson, Marc G. Caron, and M Arthur Moseley. “Quantitative label-free phosphoproteomics strategy for multifaceted experimental designs.” Anal Chem 83, no. 10 (May 15, 2011): 3758–64. https://doi.org/10.1021/ac200213b.Full Text Link to Item
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Jocoy, E. L., V. M. André, D. M. Cummings, S. P. Rao, N. Wu, A. J. Ramsey, M. G. Caron, C. Cepeda, and M. S. Levine. “Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-d-aspartate currents by dopamine D1 receptor activation in striatum.” Frontiers in Systems Neuroscience, no. MAY 2011 (May 11, 2011). https://doi.org/10.3389/fnsys.2011.00028.Full Text
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Ramsey, Amy J., Marija Milenkovic, Ana F. Oliveira, Yasmin Escobedo-Lozoya, Saurav Seshadri, Ali Salahpour, Akira Sawa, Ryohei Yasuda, and Marc G. Caron. “Impaired NMDA receptor transmission alters striatal synapses and DISC1 protein in an age-dependent manner.” Proc Natl Acad Sci U S A 108, no. 14 (April 5, 2011): 5795–5800. https://doi.org/10.1073/pnas.1012621108.Full Text Link to Item
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Martins-Silva, Cristina, Xavier De Jaeger, Monica S. Guzman, Ricardo D. F. Lima, Magda S. Santos, Christopher Kushmerick, Marcus V. Gomez, Marc G. Caron, Marco A. M. Prado, and Vania F. Prado. “Novel strains of mice deficient for the vesicular acetylcholine transporter: insights on transcriptional regulation and control of locomotor behavior.” Plos One 6, no. 3 (March 10, 2011): e17611. https://doi.org/10.1371/journal.pone.0017611.Full Text Link to Item
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Hall, F. S., J. M. Schwarzbaum, M. T. G. Perona, J. S. Templin, M. G. Caron, K. -. P. Lesch, D. L. Murphy, and G. R. Uhl. “A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception.” Neuroscience 175 (February 23, 2011): 315–27. https://doi.org/10.1016/j.neuroscience.2010.11.057.Full Text Link to Item
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Omenetti, Alessia, Liu Yang, Raul R. Gainetdinov, Cynthia D. Guy, Steve S. Choi, Wei Chen, Marc G. Caron, and Anna Mae Diehl. “Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults.” Am J Physiol Gastrointest Liver Physiol 300, no. 2 (February 2011): G303–15. https://doi.org/10.1152/ajpgi.00368.2010.Full Text Link to Item
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Urs, Nikhil M., Tanya L. Daigle, and Marc G. Caron. “A dopamine D1 receptor-dependent β-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice.” Neuropsychopharmacology 36, no. 3 (February 2011): 551–58. https://doi.org/10.1038/npp.2010.186.Full Text Link to Item
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Mathurin, Karine, Maxime A. Gallant, Pascale Germain, Hugues Allard-Chamard, Jessy Brisson, Christian Iorio-Morin, Artur de Brum Fernandes, Marc G. Caron, Stéphane A. Laporte, and Jean-Luc Parent. “An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production.” J Biol Chem 286, no. 4 (January 28, 2011): 2696–2706. https://doi.org/10.1074/jbc.M110.178277.Full Text Link to Item
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Li, Zhishan, Marc G. Caron, Randy D. Blakely, Kara G. Margolis, and Michael D. Gershon. “Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression.” J Neurosci 30, no. 49 (December 8, 2010): 16730–40. https://doi.org/10.1523/JNEUROSCI.2276-10.2010.Full Text Link to Item
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Sotnikova, Tatyana D., Jean-Martin Beaulieu, Stefano Espinoza, Bernard Masri, Xiaodong Zhang, Ali Salahpour, Larry S. Barak, Marc G. Caron, and Raul R. Gainetdinov. “The dopamine metabolite 3-methoxytyramine is a neuromodulator.” Plos One 5, no. 10 (October 18, 2010): e13452. https://doi.org/10.1371/journal.pone.0013452.Full Text Open Access Copy Link to Item
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Kenakin, Terry, Luigi F. Agnati, Marc Caron, Bertil Fredholm, Diego Guidoli, Brian Kobilka, Robert W. Lefkowitz, Martin Lohse, Amina Woods, and Kjell Fuxe. “International Workshop at the Nobel Forum, Karolinska Institutet on G protein-coupled receptors: finding the words to describe monomers, oligomers, and their molecular mechanisms and defining their meaning. Can a consensus be reached?” J Recept Signal Transduct Res 30, no. 5 (October 2010): 284–86. https://doi.org/10.3109/10799893.2010.512438.Full Text Link to Item
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Zhao, Pingwei, Haleli Sharir, Ankur Kapur, Alan Cowan, Ellen B. Geller, Martin W. Adler, Herbert H. Seltzman, et al. “Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity.” Mol Pharmacol 78, no. 4 (October 2010): 560–68. https://doi.org/10.1124/mol.110.066746.Full Text Link to Item
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Siesser, William B., Xiaodong Zhang, Jacob P. R. Jacobsen, Tatyana D. Sotnikova, Raul R. Gainetdinov, and Marc G. Caron. “Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice.” Neurosci Lett 481, no. 1 (August 30, 2010): 6–11. https://doi.org/10.1016/j.neulet.2010.06.035.Full Text Link to Item
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Dzirasa, Kafui, H Westley Phillips, Tatyana D. Sotnikova, Ali Salahpour, Sunil Kumar, Raul R. Gainetdinov, Marc G. Caron, and Miguel A. L. Nicolelis. “Noradrenergic control of cortico-striato-thalamic and mesolimbic cross-structural synchrony.” J Neurosci 30, no. 18 (May 5, 2010): 6387–97. https://doi.org/10.1523/JNEUROSCI.0764-10.2010.Full Text Link to Item
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Bowton, Erica, Christine Saunders, Kevin Erreger, Dhananjay Sakrikar, Heinrich J. Matthies, Namita Sen, Tammy Jessen, et al. “Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder.” J Neurosci 30, no. 17 (April 28, 2010): 6048–57. https://doi.org/10.1523/JNEUROSCI.5094-09.2010.Full Text Link to Item
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Lara, Aline, Denis D. Damasceno, Rita Pires, Robert Gros, Enéas R. Gomes, Mariana Gavioli, Ricardo F. Lima, et al. “Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure.” Mol Cell Biol 30, no. 7 (April 2010): 1746–56. https://doi.org/10.1128/MCB.00996-09.Full Text Link to Item
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Chen, Minyong, Melanie Philipp, Jiangbo Wang, Richard T. Premont, Tiffany R. Garrison, Marc G. Caron, Robert J. Lefkowitz, and Wei Chen. “G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.” J Biol Chem 284, no. 50 (December 11, 2009): 35040–48. https://doi.org/10.1074/jbc.M109.047456.Full Text Link to Item
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Kapur, Ankur, Pingwei Zhao, Haleli Sharir, Yushi Bai, Marc G. Caron, Larry S. Barak, and Mary E. Abood. “Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands.” J Biol Chem 284, no. 43 (October 23, 2009): 29817–27. https://doi.org/10.1074/jbc.M109.050187.Full Text Link to Item
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Castro, Braulio M. de, Xavier De Jaeger, Cristina Martins-Silva, Ricardo D. F. Lima, Ernani Amaral, Cristiane Menezes, Patricia Lima, et al. “The vesicular acetylcholine transporter is required for neuromuscular development and function.” Mol Cell Biol 29, no. 19 (October 2009): 5238–50. https://doi.org/10.1128/MCB.00245-09.Full Text Link to Item
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Haenisch, Britta, Andras Bilkei-Gorzo, Marc G. Caron, and Heinz Bönisch. “Knockout of the norepinephrine transporter and pharmacologically diverse antidepressants prevent behavioral and brain neurotrophin alterations in two chronic stress models of depression.” J Neurochem 111, no. 2 (October 2009): 403–16. https://doi.org/10.1111/j.1471-4159.2009.06345.x.Full Text Link to Item
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Hall, F. S., X. -. F. Li, J. Randall-Thompson, I. Sora, D. L. Murphy, K. -. P. Lesch, M. Caron, and G. R. Uhl. “Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout mice.” Neuroscience 162, no. 4 (September 15, 2009): 870–80. https://doi.org/10.1016/j.neuroscience.2009.05.058.Full Text Link to Item
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Sotnikova, Tatyana D., Marc G. Caron, and Raul R. Gainetdinov. “Trace amine-associated receptors as emerging therapeutic targets.” Mol Pharmacol 76, no. 2 (August 2009): 229–35. https://doi.org/10.1124/mol.109.055970.Full Text Link to Item
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Singer, Dustin, Simone M. R. Camargo, Katja Huggel, Elisa Romeo, Ursula Danilczyk, Keiji Kuba, Serge Chesnov, Marc G. Caron, Josef M. Penninger, and Francois Verrey. “Orphan transporter SLC6A18 is renal neutral amino acid transporter B0AT3.” J Biol Chem 284, no. 30 (July 24, 2009): 19953–60. https://doi.org/10.1074/jbc.M109.011171.Full Text Link to Item
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Dzirasa, Kafui, Amy J. Ramsey, Daniel Yasumasa Takahashi, Jennifer Stapleton, Juan M. Potes, Jamila K. Williams, Raul R. Gainetdinov, Koichi Sameshima, Marc G. Caron, and Miguel A. L. Nicolelis. “Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling.” J Neurosci 29, no. 25 (June 24, 2009): 8215–24. https://doi.org/10.1523/JNEUROSCI.1773-09.2009.Full Text Link to Item
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Abbas, Atheir I., Prem N. Yadav, Wei-Dong Yao, Margaret I. Arbuckle, Seth G. N. Grant, Marc G. Caron, and Bryan L. Roth. “PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors.” J Neurosci 29, no. 22 (June 3, 2009): 7124–36. https://doi.org/10.1523/JNEUROSCI.1090-09.2009.Full Text Link to Item
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Caron, Marc G., and R Mark Wightman. “"To learn, you must pay attention." Molecular insights into teachers' wisdom.” Proc Natl Acad Sci U S A 106, no. 18 (May 5, 2009): 7267–68. https://doi.org/10.1073/pnas.0903306106.Full Text Link to Item
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Hu, Yao Fei, Marc G. Caron, and Maya Sieber-Blum. “Norepinephrine transport-mediated gene expression in noradrenergic neurogenesis.” Bmc Genomics 10 (April 8, 2009): 151. https://doi.org/10.1186/1471-2164-10-151.Full Text Link to Item
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Fuentes, Romulo, Per Petersson, William B. Siesser, Marc G. Caron, and Miguel A. L. Nicolelis. “Spinal cord stimulation restores locomotion in animal models of Parkinson's disease.” Science 323, no. 5921 (March 20, 2009): 1578–82. https://doi.org/10.1126/science.1164901.Full Text Link to Item
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Kocerha, Jannet, Mohammad Ali Faghihi, Miguel A. Lopez-Toledano, Jia Huang, Amy J. Ramsey, Marc G. Caron, Nicole Sales, et al. “MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction.” Proc Natl Acad Sci U S A 106, no. 9 (March 3, 2009): 3507–12. https://doi.org/10.1073/pnas.0805854106.Full Text Link to Item
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Ferré, Sergi, Ruben Baler, Michel Bouvier, Marc G. Caron, Lakshmi A. Devi, Thierry Durroux, Kjell Fuxe, et al. “Building a new conceptual framework for receptor heteromers.” Nat Chem Biol 5, no. 3 (March 2009): 131–34. https://doi.org/10.1038/nchembio0309-131.Full Text Link to Item
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Philipp, Melanie, and Marc G. Caron. “Hedgehog signaling: is Smo a G protein-coupled receptor?” Curr Biol 19, no. 3 (February 10, 2009): R125–27. https://doi.org/10.1016/j.cub.2008.12.010.Full Text Link to Item
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Castro, B. M. de, G. S. Pereira, V. Magalhães, J. I. Rossato, X. De Jaeger, C. Martins-Silva, B. Leles, et al. “Reduced expression of the vesicular acetylcholine transporter causes learning deficits in mice.” Genes Brain Behav 8, no. 1 (February 2009): 23–35. https://doi.org/10.1111/j.1601-183X.2008.00439.x.Full Text Link to Item
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Beaulieu, Jean-Martin, Raul R. Gainetdinov, and Marc G. Caron. “Akt/GSK3 signaling in the action of psychotropic drugs.” Annu Rev Pharmacol Toxicol 49 (2009): 327–47. https://doi.org/10.1146/annurev.pharmtox.011008.145634.Full Text Link to Item
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Dzirasa, Kafui, Lucas M. Santos, Sidarta Ribeiro, Jennifer Stapleton, Raul R. Gainetdinov, Marc G. Caron, and Miguel A. L. Nicolelis. “Persistent hyperdopaminergia decreases the peak frequency of hippocampal theta oscillations during quiet waking and REM sleep.” Plos One 4, no. 4 (2009): e5238. https://doi.org/10.1371/journal.pone.0005238.Full Text Link to Item
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Ghisi, Valentina, Amy J. Ramsey, Bernard Masri, Raul R. Gainetdinov, Marc G. Caron, and Ali Salahpour. “Reduced D2-mediated signaling activity and trans-synaptic upregulation of D1 and D2 dopamine receptors in mice overexpressing the dopamine transporter.” Cell Signal 21, no. 1 (January 2009): 87–94. https://doi.org/10.1016/j.cellsig.2008.09.011.Full Text Link to Item
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Philipp, Melanie, Gregory B. Fralish, Alison R. Meloni, Wei Chen, Alyson W. MacInnes, Lawrence S. Barak, and Marc G. Caron. “Smoothened signaling in vertebrates is facilitated by a G protein-coupled receptor kinase.” Mol Biol Cell 19, no. 12 (December 2008): 5478–89. https://doi.org/10.1091/mbc.e08-05-0448.Full Text Link to Item
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Tiruchinapalli, Dhanrajan M., Marc G. Caron, and Jack D. Keene. “Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain.” J Neurochem 107, no. 6 (December 2008): 1529–43. https://doi.org/10.1111/j.1471-4159.2008.05718.x.Full Text Link to Item
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Vinuela, A., P. J. Hallett, C. Reske-Nielsen, M. Patterson, T. D. Sotnikova, M. G. Caron, R. R. Gainetdinov, and O. Isacson. “Implanted reuptake-deficient or wild-type dopaminergic neurons improve ON L-dopa dyskinesias without OFF-dyskinesias in a rat model of Parkinson's disease.” Brain 131, no. Pt 12 (December 2008): 3361–79. https://doi.org/10.1093/brain/awn192.Full Text Link to Item
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Beaulieu, Jean-Martin, and Marc G. Caron. “Looking at lithium: molecular moods and complex behaviour.” Mol Interv 8, no. 5 (October 2008): 230–41. https://doi.org/10.1124/mi.8.5.8.Full Text Link to Item
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Ramsey, Amy J., Aki Laakso, Michel Cyr, Tatyana D. Sotnikova, Ali Salahpour, Ivan O. Medvedev, Linda A. Dykstra, Raul R. Gainetdinov, and Marc G. Caron. “Genetic NMDA receptor deficiency disrupts acute and chronic effects of cocaine but not amphetamine.” Neuropsychopharmacology 33, no. 11 (October 2008): 2701–14. https://doi.org/10.1038/sj.npp.1301663.Full Text Link to Item
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Masri, Bernard, Ali Salahpour, Michael Didriksen, Valentina Ghisi, Jean-Martin Beaulieu, Raul R. Gainetdinov, and Marc G. Caron. “Antagonism of dopamine D2 receptor/beta-arrestin 2 interaction is a common property of clinically effective antipsychotics.” Proc Natl Acad Sci U S A 105, no. 36 (September 9, 2008): 13656–61. https://doi.org/10.1073/pnas.0803522105.Full Text Link to Item
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Barak, Larry S., Ali Salahpour, Xiaodong Zhang, Bernard Masri, Tatyana D. Sotnikova, Amy J. Ramsey, Jonathan D. Violin, Robert J. Lefkowitz, Marc G. Caron, and Raul R. Gainetdinov. “Pharmacological characterization of membrane-expressed human trace amine-associated receptor 1 (TAAR1) by a bioluminescence resonance energy transfer cAMP biosensor.” Mol Pharmacol 74, no. 3 (September 2008): 585–94. https://doi.org/10.1124/mol.108.048884.Full Text Link to Item
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Jensen, Niels H., Ramona M. Rodriguiz, Marc G. Caron, William C. Wetsel, Richard B. Rothman, and Bryan L. Roth. “N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity.” Neuropsychopharmacology 33, no. 10 (September 2008): 2303–12. https://doi.org/10.1038/sj.npp.1301646.Full Text Link to Item
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Perona, Maria T. G., Shonna Waters, Frank Scott Hall, Ichiro Sora, Klaus-Peter Lesch, Dennis L. Murphy, Marc Caron, and George R. Uhl. “Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions.” Behav Pharmacol 19, no. 5–6 (September 2008): 566–74. https://doi.org/10.1097/FBP.0b013e32830cd80f.Full Text Link to Item
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Powell, Susan B., Jared W. Young, Jacob C. Ong, Marc G. Caron, and Mark A. Geyer. “Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice.” Behav Pharmacol 19, no. 5–6 (September 2008): 562–65. https://doi.org/10.1097/FBP.0b013e32830dc110.Full Text Link to Item
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Beaulieu, J. M., X. Zhang, R. M. Rodriguiz, T. D. Sotnikova, W. C. Wetsel, R. R. Gainetdinov, and M. G. Caron. “Reply to Belmaker et al.: GSK3β haploinsufficiency results in lithium-like effects in the forced-swim test.” Proceedings of the National Academy of Sciences of the United States of America 105, no. 20 (May 20, 2008). https://doi.org/10.1073/pnas.0803026105.Full Text
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Murphy, Karen L., Xiaodong Zhang, Raul R. Gainetdinov, Jean-Martin Beaulieu, and Marc G. Caron. “A regulatory domain in the N terminus of tryptophan hydroxylase 2 controls enzyme expression.” J Biol Chem 283, no. 19 (May 9, 2008): 13216–24. https://doi.org/10.1074/jbc.M706749200.Full Text Link to Item
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Araujo, I. E. de, A. J. Oliveira-Maia, T. D. Sotnikova, R. R. Gainetdinov, M. G. Caron, M. A. L. Nicolelis, and S. A. Simon. “Food Reward in the Absence of Taste Receptor Signaling (DOI:10.1016/j.neuron.2008.01.032).” Neuron 58, no. 2 (April 24, 2008): 295. https://doi.org/10.1016/j.neuron.2008.04.003.Full Text
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Araujo, Ivan E. de, Albino J. Oliveira-Maia, Tatyana D. Sotnikova, Raul R. Gainetdinov, Marc G. Caron, Miguel A. L. Nicolelis, and Sidney A. Simon. “Food reward in the absence of taste receptor signaling.” Neuron 57, no. 6 (March 27, 2008): 930–41. https://doi.org/10.1016/j.neuron.2008.01.032.Full Text Link to Item
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Salahpour, Ali, Amy J. Ramsey, Ivan O. Medvedev, Brian Kile, Tatyana D. Sotnikova, Ericka Holmstrand, Valentina Ghisi, et al. “Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter.” Proc Natl Acad Sci U S A 105, no. 11 (March 18, 2008): 4405–10. https://doi.org/10.1073/pnas.0707646105.Full Text Link to Item
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Kim, Kyeong-Man, and Marc G. Caron. “Complementary roles of the DRY motif and C-terminus tail of GPCRS for G protein coupling and beta-arrestin interaction.” Biochem Biophys Res Commun 366, no. 1 (February 1, 2008): 42–47. https://doi.org/10.1016/j.bbrc.2007.11.055.Full Text Link to Item
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Beaulieu, Jean-Martin, Xiaodong Zhang, Ramona M. Rodriguiz, Tatyana D. Sotnikova, Michael J. Cools, William C. Wetsel, Raul R. Gainetdinov, and Marc G. Caron. “Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency.” Proc Natl Acad Sci U S A 105, no. 4 (January 29, 2008): 1333–38. https://doi.org/10.1073/pnas.0711496105.Full Text Link to Item
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Beaulieu, Jean-Martin, Sébastien Marion, Ramona M. Rodriguiz, Ivan O. Medvedev, Tatyana D. Sotnikova, Valentina Ghisi, William C. Wetsel, Robert J. Lefkowitz, Raul R. Gainetdinov, and Marc G. Caron. “A beta-arrestin 2 signaling complex mediates lithium action on behavior.” Cell 132, no. 1 (January 11, 2008): 125–36. https://doi.org/10.1016/j.cell.2007.11.041.Full Text Link to Item
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Sotnikova, Tatyana D., Olesya I. Zorina, Valentina Ghisi, Marc G. Caron, and Raul R. Gainetdinov. “Trace amine associated receptor 1 and movement control.” Parkinsonism Relat Disord 14 Suppl 2 (2008): S99-102. https://doi.org/10.1016/j.parkreldis.2008.04.006.Full Text Link to Item
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Fukui, Masato, Ramona M. Rodriguiz, Jiechun Zhou, Sara X. Jiang, Lindsey E. Phillips, Marc G. Caron, and William C. Wetsel. “Vmat2 heterozygous mutant mice display a depressive-like phenotype.” J Neurosci 27, no. 39 (September 26, 2007): 10520–29. https://doi.org/10.1523/JNEUROSCI.4388-06.2007.Full Text Link to Item
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Cho, Eun-Young, Dong-Im Cho, Jae H. Park, Hitoshi Kurose, Marc G. Caron, and Kyeong-Man Kim. “Roles of protein kinase C and actin-binding protein 280 in the regulation of intracellular trafficking of dopamine D3 receptor.” Mol Endocrinol 21, no. 9 (September 2007): 2242–54. https://doi.org/10.1210/me.2007-0202.Full Text Link to Item
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Swanson, James M., Glen R. Elliott, Laurence L. Greenhill, Timothy Wigal, L Eugene Arnold, Benedetto Vitiello, Lily Hechtman, et al. “Effects of stimulant medication on growth rates across 3 years in the MTA follow-up.” J Am Acad Child Adolesc Psychiatry 46, no. 8 (August 2007): 1015–27. https://doi.org/10.1097/chi.0b013e3180686d7e.Full Text Link to Item
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Marion, Sébastien, Gregory B. Fralish, Stéphane Laporte, Marc G. Caron, and Larry S. Barak. “N-terminal tyrosine modulation of the endocytic adaptor function of the beta-arrestins.” J Biol Chem 282, no. 26 (June 29, 2007): 18937–44. https://doi.org/10.1074/jbc.M700090200.Full Text Link to Item
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Costa, R. M., R. Gutierrez, I. E. de Araujo, M. R. P. Coelho, A. D. Kloth, R. R. Gainetdinov, M. G. Caron, M. A. L. Nicolelis, and S. A. Simon. “Dopamine levels modulate the updating of tastant values.” Genes Brain Behav 6, no. 4 (June 2007): 314–20. https://doi.org/10.1111/j.1601-183X.2006.00257.x.Full Text Link to Item
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Zhang, Jingping, Angel Vinuela, Mark H. Neely, Penelope J. Hallett, Seth G. N. Grant, Gregory M. Miller, Ole Isacson, Marc G. Caron, and Wei-Dong Yao. “Inhibition of the dopamine D1 receptor signaling by PSD-95.” J Biol Chem 282, no. 21 (May 25, 2007): 15778–89. https://doi.org/10.1074/jbc.M611485200.Full Text Link to Item
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Vincent, Sandra G., Andrea E. Waddell, Marc G. Caron, Julia K. L. Walker, and John T. Fisher. “A murine model of hyperdopaminergic state displays altered respiratory control.” Faseb J 21, no. 7 (May 2007): 1463–71. https://doi.org/10.1096/fj.06-7248com.Full Text Link to Item
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Beaulieu, Jean-Martin, Raul R. Gainetdinov, and Marc G. Caron. “The Akt-GSK-3 signaling cascade in the actions of dopamine.” Trends Pharmacol Sci 28, no. 4 (April 2007): 166–72. https://doi.org/10.1016/j.tips.2007.02.006.Full Text Link to Item
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Beaulieu, Jean-Martin, Emanuele Tirotta, Tatyana D. Sotnikova, Bernard Masri, Ali Salahpour, Raul R. Gainetdinov, Emiliana Borrelli, and Marc G. Caron. “Regulation of Akt signaling by D2 and D3 dopamine receptors in vivo.” J Neurosci 27, no. 4 (January 24, 2007): 881–85. https://doi.org/10.1523/JNEUROSCI.5074-06.2007.Full Text Link to Item
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Salahpour, Ali, Ivan O. Medvedev, Jean-Martin Beaulieu, Raul R. Gainetdinov, and Marc G. Caron. “Local knockdown of genes in the brain using small interfering RNA: a phenotypic comparison with knockout animals.” Biol Psychiatry 61, no. 1 (January 1, 2007): 65–69. https://doi.org/10.1016/j.biopsych.2006.03.020.Full Text Link to Item
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Cyr, Michel, Tatyana D. Sotnikova, Raul R. Gainetdinov, and Marc G. Caron. “Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin.” Faseb J 20, no. 14 (December 2006): 2541–43. https://doi.org/10.1096/fj.06-6533fje.Full Text Link to Item
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Cho, Dong-Im, SunRyeo Beom, Hubert H. M. Van Tol, Marc G. Caron, and Kyeong-Man Kim. “Characterization of the desensitization properties of five dopamine receptor subtypes and alternatively spliced variants of dopamine D2 and D4 receptors.” Biochem Biophys Res Commun 350, no. 3 (November 24, 2006): 634–40. https://doi.org/10.1016/j.bbrc.2006.09.090.Full Text Link to Item
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Dzirasa, K., S. Ribeiro, R. Costa, L. M. Santos, S. C. Lin, A. Grosmark, T. D. Sotnikova, R. R. Gainetdinov, M. G. Caron, and M. A. L. Nicolelis. “Erratum: Dopaminergic Control of Sleep-Wake States (Journal of Neuroscience (October 11, 2006) (10577-10589)).” Journal of Neuroscience 26, no. 47 (November 22, 2006).
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Dziedzicka-Wasylewska, Marta, Agata Faron-Górecka, Maciej KuĹ›mider, Elzbieta Drozdowska, Zofia Rogóz, Joanna Siwanowicz, Marc G. Caron, and Heinz Bönisch. “Effect of antidepressant drugs in mice lacking the norepinephrine transporter.” Neuropsychopharmacology 31, no. 11 (November 2006): 2424–32. https://doi.org/10.1038/sj.npp.1301064.Full Text Link to Item
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Beaulieu, Jean-Martin, Tatyana D. Sotnikova, Raul R. Gainetdinov, and Marc G. Caron. “Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice.” J Biol Chem 281, no. 43 (October 27, 2006): 32072–80. https://doi.org/10.1074/jbc.M606062200.Full Text Link to Item
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Costa, Rui M., Shih-Chieh Lin, Tatyana D. Sotnikova, Michel Cyr, Raul R. Gainetdinov, Marc G. Caron, and Miguel A. L. Nicolelis. “Rapid alterations in corticostriatal ensemble coordination during acute dopamine-dependent motor dysfunction.” Neuron 52, no. 2 (October 19, 2006): 359–69. https://doi.org/10.1016/j.neuron.2006.07.030.Full Text Link to Item
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Dzirasa, Kafui, Sidarta Ribeiro, Rui Costa, Lucas M. Santos, Shih-Chieh Lin, Andres Grosmark, Tatyana D. Sotnikova, Raul R. Gainetdinov, Marc G. Caron, and Miguel A. L. Nicolelis. “Dopaminergic control of sleep-wake states.” J Neurosci 26, no. 41 (October 11, 2006): 10577–89. https://doi.org/10.1523/JNEUROSCI.1767-06.2006.Full Text Link to Item
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Sotnikova, Tatyana D., Marc G. Caron, and Raul R. Gainetdinov. “DDD mice, a novel acute mouse model of Parkinson's disease.” Neurology 67, no. 7 Suppl 2 (October 10, 2006): S12–17. https://doi.org/10.1212/wnl.67.7_suppl_2.s12.Full Text Link to Item
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Caron, Marc G., and Raul R. Gainetdinov. “Dopamine: from pharmacology to molecular biology and back.” Wien Klin Wochenschr 118, no. 19–20 (October 2006): 565–68. https://doi.org/10.1007/s00508-006-0735-6.Full Text Link to Item
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Meloni, Alison R., Gregory B. Fralish, Patrick Kelly, Ali Salahpour, James K. Chen, Robert J. Wechsler-Reya, Robert J. Lefkowitz, and Marc G. Caron. “Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2.” Mol Cell Biol 26, no. 20 (October 2006): 7550–60. https://doi.org/10.1128/MCB.00546-06.Full Text Open Access Copy Link to Item
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Prado, Vania F., Cristina Martins-Silva, Braulio M. de Castro, Ricardo F. Lima, Daniela M. Barros, Ernani Amaral, Amy J. Ramsey, et al. “Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition.” Neuron 51, no. 5 (September 7, 2006): 601–12. https://doi.org/10.1016/j.neuron.2006.08.005.Full Text Link to Item
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Marion, Sébastien, Robert H. Oakley, Kyeong-Man Kim, Marc G. Caron, and Larry S. Barak. “A beta-arrestin binding determinant common to the second intracellular loops of rhodopsin family G protein-coupled receptors.” J Biol Chem 281, no. 5 (February 3, 2006): 2932–38. https://doi.org/10.1074/jbc.M508074200.Full Text Link to Item
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Gilsbach, R., A. Faron-Górecka, Z. Rogóz, M. Brüss, M. G. Caron, M. Dziedzicka-Wasylewska, and H. Bönisch. “Norepinephrine transporter knockout-induced up-regulation of brain alpha2A/C-adrenergic receptors.” J Neurochem 96, no. 4 (February 2006): 1111–20. https://doi.org/10.1111/j.1471-4159.2005.03598.x.Full Text Link to Item
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Sotnikova, Tatyana D., Jean-Martin Beaulieu, Raul R. Gainetdinov, and Marc G. Caron. “Molecular biology, pharmacology and functional role of the plasma membrane dopamine transporter.” Cns Neurol Disord Drug Targets 5, no. 1 (February 2006): 45–56. https://doi.org/10.2174/187152706784111579.Full Text Link to Item
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Keller, N. R., A. Diedrich, M. Appalsamy, L. C. Miller, M. G. Caron, M. P. McDonald, R. C. Shelton, R. D. Blakely, and D. Robertson. “Norepinephrine transporter-deficient mice respond to anxiety producing and fearful environments with bradycardia and hypotension.” Neuroscience 139, no. 3 (2006): 931–46. https://doi.org/10.1016/j.neuroscience.2006.01.008.Full Text Link to Item
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Zhang, X., J. -. M. Beaulieu, R. R. Gainetdinov, and M. G. Caron. “Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2.” Cell Mol Life Sci 63, no. 1 (January 2006): 6–11. https://doi.org/10.1007/s00018-005-5417-4.Full Text Link to Item
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Zhou, Zhifeng, Eric J. Peters, Steven P. Hamilton, Francis McMahon, Christee Thomas, Patrick J. McGrath, John Rush, et al. “Response to Zhang et al. (2005): loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression. Neuron 45, 11-16.” Neuron 48, no. 5 (December 8, 2005): 702–3. https://doi.org/10.1016/j.neuron.2005.11.018.Full Text Link to Item
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Beaulieu, Jean-Martin, and Marc G. Caron. “Beta-arrestin goes nuclear.” Cell 123, no. 5 (December 2, 2005): 755–57. https://doi.org/10.1016/j.cell.2005.11.010.Full Text Link to Item
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Pogorelov, Vladimir M., Ramona M. Rodriguiz, Megan L. Insco, Marc G. Caron, and William C. Wetsel. “Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene.” Neuropsychopharmacology 30, no. 10 (October 2005): 1818–31. https://doi.org/10.1038/sj.npp.1300724.Full Text Link to Item
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Pogorelov, V. M., R. M. Rodriguiz, M. L. Insco, M. G. Caron, and W. C. Wetsel. “Erratum: Novelty seeking and stereotypic activation of behavior in mice with disruption of the DatI gene (Neuropsychopharmacology (April 27, 2005), DOI:10.1038/sj.npp.1300724).” Neuropsychopharmacology 30, no. 9 (September 1, 2005): 1772. https://doi.org/10.1038/sj.npp.1300797.Full Text
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Sotnikova, Tatyana D., Jean-Martin Beaulieu, Larry S. Barak, William C. Wetsel, Marc G. Caron, and Raul R. Gainetdinov. “Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease.” Plos Biol 3, no. 8 (August 2005): e271. https://doi.org/10.1371/journal.pbio.0030271.Full Text Link to Item
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Beaulieu, Jean-Martin, Tatyana D. Sotnikova, Sébastien Marion, Robert J. Lefkowitz, Raul R. Gainetdinov, and Marc G. Caron. “An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.” Cell 122, no. 2 (July 29, 2005): 261–73. https://doi.org/10.1016/j.cell.2005.05.012.Full Text Link to Item
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Medvedev, Ivan O., Raul R. Gainetdinov, Tatyana D. Sotnikova, Laura M. Bohn, Marc G. Caron, and Linda A. Dykstra. “Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice.” Psychopharmacology (Berl) 180, no. 3 (July 2005): 408–13. https://doi.org/10.1007/s00213-005-2173-y.Full Text Link to Item
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Cyr, Michel, Marc G. Caron, G Allan Johnson, and Aki Laakso. “Magnetic resonance imaging at microscopic resolution reveals subtle morphological changes in a mouse model of dopaminergic hyperfunction.” Neuroimage 26, no. 1 (May 15, 2005): 83–90. https://doi.org/10.1016/j.neuroimage.2005.01.039.Full Text Link to Item
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Torres, Gonzalo E., and Marc G. Caron. “Approaches to identify monoamine transporter interacting proteins.” J Neurosci Methods 143, no. 1 (April 15, 2005): 63–68. https://doi.org/10.1016/j.jneumeth.2004.09.012.Full Text Link to Item
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Kim, Kyeong-Man, Raul R. Gainetdinov, Stephane A. Laporte, Marc G. Caron, and Larry S. Barak. “G protein-coupled receptor kinase regulates dopamine D3 receptor signaling by modulating the stability of a receptor-filamin-beta-arrestin complex. A case of autoreceptor regulation.” J Biol Chem 280, no. 13 (April 1, 2005): 12774–80. https://doi.org/10.1074/jbc.M408901200.Full Text Link to Item
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Vroon, Anne, Annemieke Kavelaars, Volker Limmroth, Maria Stella Lombardi, Marion U. Goebel, Anne-Marie Van Dam, Marc G. Caron, Manfred Schedlowski, and Cobi J. Heijnen. “G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis.” J Immunol 174, no. 7 (April 1, 2005): 4400–4406. https://doi.org/10.4049/jimmunol.174.7.4400.Full Text Link to Item
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Zhang, Xiaodong, Raul R. Gainetdinov, Jean-Martin Beaulieu, Tatyana D. Sotnikova, Lauranell H. Burch, Redford B. Williams, David A. Schwartz, K Ranga R. Krishnan, and Marc G. Caron. “Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.” Neuron 45, no. 1 (January 6, 2005): 11–16. https://doi.org/10.1016/j.neuron.2004.12.014.Full Text Link to Item
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Wilbanks, Alyson M., Gregory B. Fralish, Margaret L. Kirby, Larry S. Barak, Yin-Xiong Li, and Marc G. Caron. “Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway.” Science 306, no. 5705 (December 24, 2004): 2264–67. https://doi.org/10.1126/science.1104193.Full Text Link to Item
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Robertson, George S., Christopher J. Lee, Kavita Sridhar, Yusaku Nakabeppu, Michael Cheng, Yan-Min Wang, and Marc G. Caron. “Clozapine-, but not haloperidol-, induced increases in deltaFosB-like immunoreactivity are completely blocked in the striatum of mice lacking D3 dopamine receptors.” Eur J Neurosci 20, no. 11 (December 2004): 3189–94. https://doi.org/10.1111/j.1460-9568.2004.03774.x.Full Text Link to Item
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Torres, Gonzalo E., Ava L. Sweeney, Jean-Martin Beaulieu, Pullani Shashidharan, and Marc G. Caron. “Effect of torsinA on membrane proteins reveals a loss of function and a dominant-negative phenotype of the dystonia-associated DeltaE-torsinA mutant.” Proc Natl Acad Sci U S A 101, no. 44 (November 2, 2004): 15650–55. https://doi.org/10.1073/pnas.0308088101.Full Text Link to Item
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Sotnikova, Tatyana D., Evgeny A. Budygin, Sara R. Jones, Linda A. Dykstra, Marc G. Caron, and Raul R. Gainetdinov. “Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamine.” J Neurochem 91, no. 2 (October 2004): 362–73. https://doi.org/10.1111/j.1471-4159.2004.02721.x.Full Text Link to Item
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Vizi, E Sylvester, Gabriella Zsilla, Marc G. Caron, and János P. Kiss. “Uptake and release of norepinephrine by serotonergic terminals in norepinephrine transporter knock-out mice: implications for the action of selective serotonin reuptake inhibitors.” J Neurosci 24, no. 36 (September 8, 2004): 7888–94. https://doi.org/10.1523/JNEUROSCI.1506-04.2004.Full Text Link to Item
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Keller, Nancy R., André Diedrich, Martin Appalsamy, Sunti Tuntrakool, Suzanna Lonce, Charlene Finney, Marc G. Caron, and David Robertson. “Norepinephrine transporter-deficient mice exhibit excessive tachycardia and elevated blood pressure with wakefulness and activity.” Circulation 110, no. 10 (September 7, 2004): 1191–96. https://doi.org/10.1161/01.CIR.0000141804.90845.E6.Full Text Link to Item
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Zhang, Xiaodong, Jean-Martin Beaulieu, Tatyana D. Sotnikova, Raul R. Gainetdinov, and Marc G. Caron. “Tryptophan hydroxylase-2 controls brain serotonin synthesis.” Science 305, no. 5681 (July 9, 2004): 217. https://doi.org/10.1126/science.1097540.Full Text Link to Item
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Beom, SunRyeo, Dawoon Cheong, Gonzalo Torres, Marc G. Caron, and Kyeong-Man Kim. “Comparative studies of molecular mechanisms of dopamine D2 and D3 receptors for the activation of extracellular signal-regulated kinase.” J Biol Chem 279, no. 27 (July 2, 2004): 28304–14. https://doi.org/10.1074/jbc.M403899200.Full Text Link to Item
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Bohn, L. M., L. A. Dykstra, R. J. Lefkowitz, M. G. Caron, and L. S. Barak. “Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery.” Mol Pharmacol 66, no. 1 (July 2004): 106–12. https://doi.org/10.1124/mol.66.1.106.Full Text Link to Item
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Xu, Mei, Michael Petraschka, Jay P. McLaughlin, Ruth E. Westenbroek, Marc G. Caron, Robert J. Lefkowitz, Traci A. Czyzyk, John E. Pintar, Gregory W. Terman, and Charles Chavkin. “Neuropathic pain activates the endogenous kappa opioid system in mouse spinal cord and induces opioid receptor tolerance.” J Neurosci 24, no. 19 (May 12, 2004): 4576–84. https://doi.org/10.1523/JNEUROSCI.5552-03.2004.Full Text Open Access Copy Link to Item
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Powell, Susan B., Virginia D. Lehmann-Masten, Martin P. Paulus, Raul R. Gainetdinov, Marc G. Caron, and Mark A. Geyer. “MDMA "ecstasy" alters hyperactive and perseverative behaviors in dopamine transporter knockout mice.” Psychopharmacology (Berl) 173, no. 3–4 (May 2004): 310–17. https://doi.org/10.1007/s00213-003-1765-7.Full Text Link to Item
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Quan, Hui, Krairerk Athirakul, William C. Wetsel, Gonzalo E. Torres, Robert Stevens, Y. T. Chen, Thomas M. Coffman, and Marc G. Caron. “Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2.” Mol Cell Biol 24, no. 10 (May 2004): 4166–73. https://doi.org/10.1128/mcb.24.10.4166-4173.2004.Full Text Link to Item
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Vroon, Anne, Cobi J. Heijnen, Maria Stella Lombardi, Pieter M. Cobelens, Federico Mayor, Marc G. Caron, and Annemieke Kavelaars. “Reduced GRK2 level in T cells potentiates chemotaxis and signaling in response to CCL4.” J Leukoc Biol 75, no. 5 (May 2004): 901–9. https://doi.org/10.1189/jlb.0403136.Full Text Link to Item
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Beaulieu, Jean-Martin, Tatyana D. Sotnikova, Wei-Dong Yao, Lisa Kockeritz, James R. Woodgett, Raul R. Gainetdinov, and Marc G. Caron. “Lithium antagonizes dopamine-dependent behaviors mediated by an AKT/glycogen synthase kinase 3 signaling cascade.” Proc Natl Acad Sci U S A 101, no. 14 (April 6, 2004): 5099–5104. https://doi.org/10.1073/pnas.0307921101.Full Text Link to Item
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Yao, Wei-Dong, Raul R. Gainetdinov, Margaret I. Arbuckle, Tatyana D. Sotnikova, Michel Cyr, Jean-Martin Beaulieu, Gonzalo E. Torres, Seth G. N. Grant, and Marc G. Caron. “Identification of PSD-95 as a regulator of dopamine-mediated synaptic and behavioral plasticity.” Neuron 41, no. 4 (February 19, 2004): 625–38. https://doi.org/10.1016/s0896-6273(04)00048-0.Full Text Link to Item
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Barr, Alasdair M., Virginia Lehmann-Masten, Martin Paulus, Raul R. Gainetdinov, Marc G. Caron, and Mark A. Geyer. “The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout mice.” Neuropsychopharmacology 29, no. 2 (February 2004): 221–28. https://doi.org/10.1038/sj.npp.1300343.Full Text Link to Item
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Walker, J. K. L., R. R. Gainetdinov, D. S. Feldman, P. K. McFawn, M. G. Caron, R. J. Lefkowitz, R. T. Premont, and J. T. Fisher. “G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation.” Am J Physiol Lung Cell Mol Physiol 286, no. 2 (February 2004): L312–19. https://doi.org/10.1152/ajplung.00255.2003.Full Text Link to Item
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Marion, Sébastien, David M. Weiner, and Marc G. Caron. “RNA editing induces variation in desensitization and trafficking of 5-hydroxytryptamine 2c receptor isoforms.” J Biol Chem 279, no. 4 (January 23, 2004): 2945–54. https://doi.org/10.1074/jbc.M308742200.Full Text Link to Item
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McLaughlin, Jay P., Lisa C. Myers, Paul E. Zarek, Marc G. Caron, Robert J. Lefkowitz, Traci A. Czyzyk, John E. Pintar, and Charles Chavkin. “Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance.” J Biol Chem 279, no. 3 (January 16, 2004): 1810–18. https://doi.org/10.1074/jbc.M305796200.Full Text Link to Item
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Rodriguiz, Ramona M., Richard Chu, Marc G. Caron, and William C. Wetsel. “Aberrant responses in social interaction of dopamine transporter knockout mice.” Behav Brain Res 148, no. 1–2 (January 5, 2004): 185–98. https://doi.org/10.1016/s0166-4328(03)00187-6.Full Text Link to Item
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Bohn, Laura M., Raul R. Gainetdinov, and Marc G. Caron. “G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice.” Neuromolecular Med 5, no. 1 (2004): 41–50. https://doi.org/10.1385/NMM:5:1:041.Full Text Link to Item
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Ferguson, Stephen S. G., and Marc G. Caron. “Green fluorescent protein-tagged beta-arrestin translocation as a measure of G protein-coupled receptor activation.” Methods Mol Biol 237 (2004): 121–26. https://doi.org/10.1385/1-59259-430-1:121.Full Text Link to Item
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Gainetdinov, Raul R., Richard T. Premont, Laura M. Bohn, Robert J. Lefkowitz, and Marc G. Caron. “Desensitization of G protein-coupled receptors and neuronal functions.” Annu Rev Neurosci 27 (2004): 107–44. https://doi.org/10.1146/annurev.neuro.27.070203.144206.Full Text Link to Item
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Mohn, Amy R., Wei-Dong Yao, and Marc G. Caron. “Genetic and genomic approaches to reward and addiction.” Neuropharmacology 47 Suppl 1 (2004): 101–10. https://doi.org/10.1016/j.neuropharm.2004.07.025.Full Text Link to Item
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Terman, Gregory W., Wenzhen Jin, Young-Pyo Cheong, Janet Lowe, Marc G. Caron, Robert J. Lefkowitz, and Charles Chavkin. “G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal.” Br J Pharmacol 141, no. 1 (January 2004): 55–64. https://doi.org/10.1038/sj.bjp.0705595.Full Text Link to Item
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Johnson, Erik C., Laura M. Bohn, Larry S. Barak, Ryan T. Birse, Dick R. Nässel, Marc G. Caron, and Paul H. Taghert. “Identification of Drosophila neuropeptide receptors by G protein-coupled receptors-beta-arrestin2 interactions.” J Biol Chem 278, no. 52 (December 26, 2003): 52172–78. https://doi.org/10.1074/jbc.M306756200.Full Text Link to Item
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Bohn, Laura M., Raul R. Gainetdinov, Tatyana D. Sotnikova, Ivan O. Medvedev, Robert J. Lefkowitz, Linda A. Dykstra, and Marc G. Caron. “Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice.” J Neurosci 23, no. 32 (November 12, 2003): 10265–73.Open Access Copy Link to Item
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Cyr, Michel, Jean-Martin Beaulieu, Aki Laakso, Tatyana D. Sotnikova, Wei-Dong Yao, Laura M. Bohn, Raul R. Gainetdinov, and Marc G. Caron. “Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons.” Proc Natl Acad Sci U S A 100, no. 19 (September 16, 2003): 11035–40. https://doi.org/10.1073/pnas.1831768100.Full Text Link to Item
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Chen, Wei, Derk ten Berge, Jeff Brown, Seungkirl Ahn, Liaoyuan A. Hu, William E. Miller, Marc G. Caron, Larry S. Barak, Roel Nusse, and Robert J. Lefkowitz. “Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4.” Science 301, no. 5638 (September 5, 2003): 1391–94. https://doi.org/10.1126/science.1082808.Full Text Link to Item
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Torres, Gonzalo E., and Marc G. Caron. “Center stage for the serotonin transporter: a gain-of-function polymorphism in persons with obsessive-compulsive disorder.” Mol Pharmacol 64, no. 2 (August 2003): 196–98. https://doi.org/10.1124/mol.64.2.196.Full Text Link to Item
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Miyakawa, Tsuyoshi, Lorene M. Leiter, David J. Gerber, Raul R. Gainetdinov, Tatyana D. Sotnikova, Hongkui Zeng, Marc G. Caron, and Susumu Tonegawa. “Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia.” Proc Natl Acad Sci U S A 100, no. 15 (July 22, 2003): 8987–92. https://doi.org/10.1073/pnas.1432926100.Full Text Link to Item
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Gainetdinov, Raul R., Laura M. Bohn, Tatyana D. Sotnikova, Michel Cyr, Aki Laakso, Alexander D. Macrae, Gonzalo E. Torres, et al. “Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice.” Neuron 38, no. 2 (April 24, 2003): 291–303. https://doi.org/10.1016/s0896-6273(03)00192-2.Full Text Link to Item
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Barak, Larry S., Alyson M. Wilbanks, and Marc G. Caron. “Constitutive desensitization: a new paradigm for g protein-coupled receptor regulation.” Assay Drug Dev Technol 1, no. 2 (April 2003): 339–46. https://doi.org/10.1089/15406580360545152.Full Text Link to Item
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Tohgo, Akira, Eric W. Choy, Diane Gesty-Palmer, Kristen L. Pierce, Stephane Laporte, Robert H. Oakley, Marc G. Caron, Robert J. Lefkowitz, and Louis M. Luttrell. “The stability of the G protein-coupled receptor-beta-arrestin interaction determines the mechanism and functional consequence of ERK activation.” J Biol Chem 278, no. 8 (February 21, 2003): 6258–67. https://doi.org/10.1074/jbc.M212231200.Full Text Link to Item
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Torres, Gonzalo E., Ana Carneiro, Katie Seamans, Chiara Fiorentini, Ava Sweeney, Wei-Dong Yao, and Marc G. Caron. “Oligomerization and trafficking of the human dopamine transporter. Mutational analysis identifies critical domains important for the functional expression of the transporter.” J Biol Chem 278, no. 4 (January 24, 2003): 2731–39. https://doi.org/10.1074/jbc.M201926200.Full Text Link to Item
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Gainetdinov, Raul R., and Marc G. Caron. “Monoamine transporters: from genes to behavior.” Annu Rev Pharmacol Toxicol 43 (2003): 261–84. https://doi.org/10.1146/annurev.pharmtox.43.050802.112309.Full Text Link to Item
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Torres, Gonzalo E., Raul R. Gainetdinov, and Marc G. Caron. “Plasma membrane monoamine transporters: structure, regulation and function.” Nat Rev Neurosci 4, no. 1 (January 2003): 13–25. https://doi.org/10.1038/nrn1008.Full Text Link to Item
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Trinh, J. V., D. L. Nehrenberg, J. P. R. Jacobsen, M. G. Caron, and W. C. Wetsel. “Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice.” Neuroscience 118, no. 2 (2003): 297–310. https://doi.org/10.1016/s0306-4522(03)00165-9.Full Text Link to Item
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Bohn, Laura M., Robert J. Lefkowitz, and Marc G. Caron. “Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice.” J Neurosci 22, no. 23 (December 1, 2002): 10494–500.Open Access Copy Link to Item
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Laakso, Aki, Amy R. Mohn, Raul R. Gainetdinov, and Marc G. Caron. “Experimental genetic approaches to addiction.” Neuron 36, no. 2 (October 10, 2002): 213–28. https://doi.org/10.1016/s0896-6273(02)00972-8.Full Text Link to Item
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Wilbanks, Alyson M., Stéphane A. Laporte, Laura M. Bohn, Larry S. Barak, and Marc G. Caron. “Apparent loss-of-function mutant GPCRs revealed as constitutively desensitized receptors.” Biochemistry 41, no. 40 (October 8, 2002): 11981–89. https://doi.org/10.1021/bi020275m.Full Text Link to Item
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Barbosa, José, Lucimar T. Ferreira, C. Martins-Silva, Magda S. Santos, Gonzalo E. Torres, Marc G. Caron, Marcus V. Gomez, Stephen S. G. Ferguson, Marco A. M. Prado, and Vania F. Prado. “Trafficking of the vesicular acetylcholine transporter in SN56 cells: a dynamin-sensitive step and interaction with the AP-2 adaptor complex.” J Neurochem 82, no. 5 (September 2002): 1221–28. https://doi.org/10.1046/j.1471-4159.2002.01068.x.Full Text Link to Item
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Gainetdinov, R. R., T. D. Sotnikova, and M. G. Caron. “Erratum: Monoamine transporter pharmacology and mutant mice (Trends in Pharmacological Sciences (August 2002) (371)).” Trends in Pharmacological Sciences 23, no. 9 (September 1, 2002): 443. https://doi.org/10.1016/s0165-6147(02)02114-4.Full Text
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Carneiro, Ana M., Susan L. Ingram, Jean-Martin Beaulieu, Ava Sweeney, Susan G. Amara, Sheila M. Thomas, Marc G. Caron, and Gonzalo E. Torres. “The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter.” J Neurosci 22, no. 16 (August 15, 2002): 7045–54.Link to Item
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Naga Prasad, Sathyamangla V., Stéphane A. Laporte, Dean Chamberlain, Marc G. Caron, Larry Barak, and Howard A. Rockman. “Phosphoinositide 3-kinase regulates beta2-adrenergic receptor endocytosis by AP-2 recruitment to the receptor/beta-arrestin complex.” J Cell Biol 158, no. 3 (August 5, 2002): 563–75. https://doi.org/10.1083/jcb.200202113.Full Text Link to Item
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Gainetdinov, Raul R., Tatyana D. Sotnikova, and Marc G. Caron. “Monoamine transporter pharmacology and mutant mice.” Trends Pharmacol Sci 23, no. 8 (August 2002): 367–73. https://doi.org/10.1016/s0165-6147(02)02044-8.Full Text Link to Item
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Haller, József, Nikoletta Bakos, Ramona M. Rodriguiz, Marc G. Caron, William C. Wetsel, and Zsolt Liposits. “Behavioral responses to social stress in noradrenaline transporter knockout mice: effects on social behavior and depression.” Brain Res Bull 58, no. 3 (July 2002): 279–84. https://doi.org/10.1016/s0361-9230(02)00789-x.Full Text Link to Item
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Savelieva, Katerina V., W Michael Caudle, Geoffrey S. Findlay, Marc G. Caron, and Gary W. Miller. “Decreased ethanol preference and consumption in dopamine transporter female knock-out mice.” Alcohol Clin Exp Res 26, no. 6 (June 2002): 758–64.Link to Item
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Kim, You-Me, Larry S. Barak, Marc G. Caron, and Jeffrey L. Benovic. “Regulation of arrestin-3 phosphorylation by casein kinase II.” J Biol Chem 277, no. 19 (May 10, 2002): 16837–46. https://doi.org/10.1074/jbc.M201379200.Full Text Link to Item
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Richfield, Eric K., Mona J. Thiruchelvam, Deborah A. Cory-Slechta, Charles Wuertzer, Raul R. Gainetdinov, Marc G. Caron, Donato A. Di Monte, and Howard J. Federoff. “Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice.” Exp Neurol 175, no. 1 (May 2002): 35–48. https://doi.org/10.1006/exnr.2002.7882.Full Text Link to Item
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Laporte, Stephane A., William E. Miller, Kyeong-Man Kim, and Marc G. Caron. “beta-Arrestin/AP-2 interaction in G protein-coupled receptor internalization: identification of a beta-arrestin binging site in beta 2-adaptin.” J Biol Chem 277, no. 11 (March 15, 2002): 9247–54. https://doi.org/10.1074/jbc.M108490200.Full Text Link to Item
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Claing, Audrey, Stéphane A. Laporte, Marc G. Caron, and Robert J. Lefkowitz. “Endocytosis of G protein-coupled receptors: roles of G protein-coupled receptor kinases and beta-arrestin proteins.” Prog Neurobiol 66, no. 2 (February 2002): 61–79. https://doi.org/10.1016/s0301-0082(01)00023-5.Full Text Link to Item
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Seachrist, Jennifer L., Stephane A. Laporte, Lianne B. Dale, Andy V. Babwah, Marc G. Caron, Pieter H. Anborgh, and Stephen S. G. Ferguson. “Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusion.” J Biol Chem 277, no. 1 (January 4, 2002): 679–85. https://doi.org/10.1074/jbc.M109022200.Full Text Link to Item
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Hall, F. S., X. F. Li, I. Sora, F. Xu, M. Caron, K. P. Lesch, D. L. Murphy, and G. R. Uhl. “Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions.” Neuroscience 115, no. 1 (2002): 153–61. https://doi.org/10.1016/s0306-4522(02)00379-2.Full Text Link to Item
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Joseph, J. D., Y. -. M. Wang, P. R. Miles, E. A. Budygin, R. Picetti, R. R. Gainetdinov, M. G. Caron, and R. M. Wightman. “Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D(3) receptors.” Neuroscience 112, no. 1 (2002): 39–49. https://doi.org/10.1016/s0306-4522(02)00067-2.Full Text Link to Item
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Gerber, D. J., T. D. Sotnikova, R. R. Gainetdinov, S. Y. Huang, M. G. Caron, and S. Tonegawa. “Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice.” Proc Natl Acad Sci U S A 98, no. 26 (December 18, 2001): 15312–17. https://doi.org/10.1073/pnas.261583798.Full Text Link to Item
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Gu, H. H., X. Wu, B. Giros, M. G. Caron, M. J. Caplan, and G. Rudnick. “The NH(2)-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells.” Mol Biol Cell 12, no. 12 (December 2001): 3797–3807. https://doi.org/10.1091/mbc.12.12.3797.Full Text Link to Item
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Kim, K. M., K. J. Valenzano, S. R. Robinson, W. D. Yao, L. S. Barak, and M. G. Caron. “Differential regulation of the dopamine D2 and D3 receptors by G protein-coupled receptor kinases and beta-arrestins.” J Biol Chem 276, no. 40 (October 5, 2001): 37409–14. https://doi.org/10.1074/jbc.M106728200.Full Text Link to Item
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Mundorf, M. L., J. D. Joseph, C. M. Austin, M. G. Caron, and R. M. Wightman. “Catecholamine release and uptake in the mouse prefrontal cortex.” J Neurochem 79, no. 1 (October 2001): 130–42. https://doi.org/10.1046/j.1471-4159.2001.00554.x.Full Text Link to Item
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Gainetdinov, R. R., A. R. Mohn, L. M. Bohn, and M. G. Caron. “Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter.” Proc Natl Acad Sci U S A 98, no. 20 (September 25, 2001): 11047–54. https://doi.org/10.1073/pnas.191353298.Full Text Link to Item
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Gainetdinov, R. R., A. R. Mohn, and M. G. Caron. “Genetic animal models: focus on schizophrenia.” Trends Neurosci 24, no. 9 (September 2001): 527–33. https://doi.org/10.1016/s0166-2236(00)01886-5.Full Text Link to Item
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Premont, R. T., R. R. Gainetdinov, and M. G. Caron. “Following the trace of elusive amines.” Proc Natl Acad Sci U S A 98, no. 17 (August 14, 2001): 9474–75. https://doi.org/10.1073/pnas.181356198.Full Text Link to Item
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Laporte, S. A., R. H. Oakley, and M. G. Caron. “Signal transduction. Bringing channels closer to the action!.” Science 293, no. 5527 (July 6, 2001): 62–63. https://doi.org/10.1126/science.1063104.Full Text Link to Item
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Pifl, C., J. Zezula, A. Spittler, A. Kattinger, H. Reither, M. G. Caron, and O. Hornykiewicz. “Antiproliferative action of dopamine and norepinephrine in neuroblastoma cells expressing the human dopamine transporter.” Faseb J 15, no. 9 (July 2001): 1607–9. https://doi.org/10.1096/fj.00-0738fje.Full Text Link to Item
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Naga Prasad, S. V., L. S. Barak, A. Rapacciuolo, M. G. Caron, and H. A. Rockman. “Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration.” J Biol Chem 276, no. 22 (June 1, 2001): 18953–59. https://doi.org/10.1074/jbc.M102376200.Full Text Link to Item
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Oakley, R. H., S. A. Laporte, J. A. Holt, L. S. Barak, and M. G. Caron. “Molecular determinants underlying the formation of stable intracellular G protein-coupled receptor-beta-arrestin complexes after receptor endocytosis*.” J Biol Chem 276, no. 22 (June 1, 2001): 19452–60. https://doi.org/10.1074/jbc.M101450200.Full Text Link to Item
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Torres, G. E., W. D. Yao, A. R. Mohn, H. Quan, K. M. Kim, A. I. Levey, J. Staudinger, and M. G. Caron. “Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1.” Neuron 30, no. 1 (April 2001): 121–34. https://doi.org/10.1016/s0896-6273(01)00267-7.Full Text Link to Item
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Hobson, J. P., H. M. Rosenfeldt, L. S. Barak, A. Olivera, S. Poulton, M. G. Caron, S. Milstien, and S. Spiegel. “Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility.” Science 291, no. 5509 (March 2, 2001): 1800–1803. https://doi.org/10.1126/science.1057559.Full Text Link to Item
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Gainetdinov, R. R., and M. G. Caron. “Genetics of childhood disorders: XXIV. ADHD, part 8: hyperdopaminergic mice as an animal model of ADHD.” J Am Acad Child Adolesc Psychiatry 40, no. 3 (March 2001): 380–82. https://doi.org/10.1097/00004583-200103000-00020.Full Text Link to Item
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Zhuang, X., R. S. Oosting, S. R. Jones, R. R. Gainetdinov, G. W. Miller, M. G. Caron, and R. Hen. “Hyperactivity and impaired response habituation in hyperdopaminergic mice.” Proc Natl Acad Sci U S A 98, no. 4 (February 13, 2001): 1982–87. https://doi.org/10.1073/pnas.98.4.1982.Full Text Link to Item
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Barak, L. S., R. H. Oakley, S. A. Laporte, and M. G. Caron. “Constitutive arrestin-mediated desensitization of a human vasopressin receptor mutant associated with nephrogenic diabetes insipidus.” Proc Natl Acad Sci U S A 98, no. 1 (January 2, 2001): 93–98. https://doi.org/10.1073/pnas.011303698.Full Text Link to Item
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Gu, H. H., X. Wu, B. Giros, M. G. Caron, M. J. Caplan, and G. Rudnick. “The NH2-terminus of norepinephrine transporter contains a basolateral localization signal for epithelial cells.” Molecular Biology of the Cell 12, no. 12 (2001): 3797–3807.
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Miller, G. W., Y. M. Wang, R. R. Gainetdinov, and M. G. Caron. “Dopamine transporter and vesicular monoamine transporter knockout mice : implications for Parkinson's disease.” Methods Mol Med 62 (2001): 179–90. https://doi.org/10.1385/1-59259-142-6:179.Full Text Link to Item
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Ralph, R. J., M. P. Paulus, F. Fumagalli, M. G. Caron, and M. A. Geyer. “Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists.” J Neurosci 21, no. 1 (January 1, 2001): 305–13.Link to Item
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Bohn, L. M., F. Xu, R. R. Gainetdinov, and M. G. Caron. “Potentiated opioid analgesia in norepinephrine transporter knock-out mice.” J Neurosci 20, no. 24 (December 15, 2000): 9040–45.Link to Item
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Bohn, L. M., R. R. Gainetdinov, F. T. Lin, R. J. Lefkowitz, and M. G. Caron. “Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.” Nature 408, no. 6813 (December 7, 2000): 720–23. https://doi.org/10.1038/35047086.Full Text Link to Item
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Caron, M. G. “Endocrine Reviews: Editorial.” Endocrine Reviews 21, no. 1 (December 1, 2000): 3. https://doi.org/10.1210/er.21.1.3.Full Text
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Caron, M. G., A. R. Mohn, and R. R. Gainetdinov. “Manifestation of dopamine and glutamate systems dysfunction in animal models of schizoid behavior.” Acta Neurologica Scandinavica, Supplement 102, no. 175 (December 1, 2000): 14–15.
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Gainetdinov, R. R., R. T. Premont, M. G. Caron, and R. J. Lefkowitz. “Reply: receptor specificity of G-protein-coupled receptor kinases.” Trends Pharmacol Sci 21, no. 10 (October 2000): 366–67. https://doi.org/10.1016/s0165-6147(00)01538-8.Full Text Link to Item
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Ciliax, B. J., N. Nash, C. Heilman, R. Sunahara, A. Hartney, M. Tiberi, D. B. Rye, M. G. Caron, H. B. Niznik, and A. I. Levey. “Dopamine D(5) receptor immunolocalization in rat and monkey brain.” Synapse 37, no. 2 (August 2000): 125–45. https://doi.org/10.1002/1098-2396(200008)37:2<125::AID-SYN7>3.0.CO;2-7.Full Text Link to Item
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Walker, J. K., R. R. Gainetdinov, A. W. Mangel, M. G. Caron, and M. A. Shetzline. “Mice lacking the dopamine transporter display altered regulation of distal colonic motility.” Am J Physiol Gastrointest Liver Physiol 279, no. 2 (August 2000): G311–18. https://doi.org/10.1152/ajpgi.2000.279.2.G311.Full Text Link to Item
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Laporte, S. A., R. H. Oakley, J. A. Holt, L. S. Barak, and M. G. Caron. “The interaction of beta-arrestin with the AP-2 adaptor is required for the clustering of beta 2-adrenergic receptor into clathrin-coated pits.” J Biol Chem 275, no. 30 (July 28, 2000): 23120–26. https://doi.org/10.1074/jbc.M002581200.Full Text Link to Item
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Oakley, R. H., S. A. Laporte, J. A. Holt, M. G. Caron, and L. S. Barak. “Differential affinities of visual arrestin, beta arrestin1, and beta arrestin2 for G protein-coupled receptors delineate two major classes of receptors.” J Biol Chem 275, no. 22 (June 2, 2000): 17201–10. https://doi.org/10.1074/jbc.M910348199.Full Text Link to Item
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Spielewoy, C., F. Gonon, C. Roubert, V. Fauchey, M. Jaber, M. G. Caron, B. P. Roques, et al. “Increased rewarding properties of morphine in dopamine-transporter knockout mice.” Eur J Neurosci 12, no. 5 (May 2000): 1827–37. https://doi.org/10.1046/j.1460-9568.2000.00063.x.Full Text Link to Item
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Xu, F., R. R. Gainetdinov, W. C. Wetsel, S. R. Jones, L. M. Bohn, G. W. Miller, Y. M. Wang, and M. G. Caron. “Mice lacking the norepinephrine transporter are supersensitive to psychostimulants.” Nat Neurosci 3, no. 5 (May 2000): 465–71. https://doi.org/10.1038/74839.Full Text Link to Item
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Carman, C. V., L. S. Barak, C. Chen, L. Y. Liu-Chen, J. J. Onorato, S. P. Kennedy, M. G. Caron, and J. L. Benovic. “Mutational analysis of Gbetagamma and phospholipid interaction with G protein-coupled receptor kinase 2.” J Biol Chem 275, no. 14 (April 7, 2000): 10443–52. https://doi.org/10.1074/jbc.275.14.10443.Full Text Link to Item
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Sarkis, E. H. “"Model" behavior.” Science 287, no. 5461 (March 24, 2000): 2160–62. https://doi.org/10.1126/science.287.5461.2159e.Full Text Link to Item
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Dumartin, B., M. Jaber, F. Gonon, M. G. Caron, B. Giros, and B. Bloch. “Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice.” Proc Natl Acad Sci U S A 97, no. 4 (February 15, 2000): 1879–84. https://doi.org/10.1073/pnas.97.4.1879.Full Text Link to Item
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Travis, E. R., Y. M. Wang, D. J. Michael, M. G. Caron, and R. M. Wightman. “Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice.” Proc Natl Acad Sci U S A 97, no. 1 (January 4, 2000): 162–67. https://doi.org/10.1073/pnas.97.1.162.Full Text Link to Item
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Bliziotes, M., S. McLoughlin, M. Gunness, F. Fumagalli, S. R. Jones, and M. G. Caron. “Bone histomorphometric and biomechanical abnormalities in mice homozygous for deletion of the dopamine transporter gene.” Bone 26, no. 1 (January 2000): 15–19. https://doi.org/10.1016/s8756-3282(99)00232-x.Full Text Link to Item
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Bouvier, M., S. A. Laporte, M. Lagacé, and M. G. Caron. “Protein scaffoldings and modular signaling through seven transmembrane domain-receptors: Beyond the G proteins.” Medecine/Sciences 16, no. 5 (January 1, 2000): 644–51. https://doi.org/10.4267/10608/2054.Full Text
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Fauchey, V., M. Jaber, M. G. Caron, B. Bloch, and C. Le Moine. “Differential regulation of the dopamine D1, D2 and D3 receptor gene expression and changes in the phenotype of the striatal neurons in mice lacking the dopamine transporter.” Eur J Neurosci 12, no. 1 (January 2000): 19–26. https://doi.org/10.1046/j.1460-9568.2000.00876.x.Full Text Link to Item
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Gainetdinov, R. R., and M. G. Caron. “An animal model of attention deficit hyperactivity disorder.” Mol Med Today 6, no. 1 (January 2000): 43–44. https://doi.org/10.1016/s1357-4310(99)01616-0.Full Text Link to Item
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Bohn, L. M., R. J. Lefkowitz, R. R. Gainetdinov, K. Peppel, M. G. Caron, and F. T. Lin. “Enhanced morphine analgesia in mice lacking beta-arrestin 2.” Science 286, no. 5449 (December 24, 1999): 2495–98. https://doi.org/10.1126/science.286.5449.2495.Full Text Link to Item
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Gainetdinov, R. R., L. M. Bohn, J. K. Walker, S. A. Laporte, A. D. Macrae, M. G. Caron, R. J. Lefkowitz, and R. T. Premont. “Muscarinic supersensitivity and impaired receptor desensitization in G protein-coupled receptor kinase 5-deficient mice.” Neuron 24, no. 4 (December 1999): 1029–36. https://doi.org/10.1016/s0896-6273(00)81048-x.Full Text Link to Item
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Jones, S. R., J. D. Joseph, L. S. Barak, M. G. Caron, and R. M. Wightman. “Dopamine neuronal transport kinetics and effects of amphetamine.” J Neurochem 73, no. 6 (December 1999): 2406–14. https://doi.org/10.1046/j.1471-4159.1999.0732406.x.Full Text Link to Item
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Oakley, R. H., S. A. Laporte, J. A. Holt, L. S. Barak, and M. G. Caron. “Association of beta-arrestin with G protein-coupled receptors during clathrin-mediated endocytosis dictates the profile of receptor resensitization.” J Biol Chem 274, no. 45 (November 5, 1999): 32248–57. https://doi.org/10.1074/jbc.274.45.32248.Full Text Link to Item
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Jones, S. R., R. R. Gainetdinov, and M. G. Caron. “Application of microdialysis and voltammetry to assess dopamine functions in genetically altered mice: correlation with locomotor activity.” Psychopharmacology (Berl) 147, no. 1 (November 1999): 30–32. https://doi.org/10.1007/s002130051137.Full Text Link to Item
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Wang, Y. M., F. Xu, R. R. Gainetdinov, and M. G. Caron. “Genetic approaches to studying norepinephrine function: knockout of the mouse norepinephrine transporter gene.” Biol Psychiatry 46, no. 9 (November 1, 1999): 1124–30. https://doi.org/10.1016/s0006-3223(99)00245-0.Full Text Link to Item
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Walker, J. K., R. T. Premont, L. S. Barak, M. G. Caron, and M. A. Shetzline. “Properties of secretin receptor internalization differ from those of the beta(2)-adrenergic receptor.” J Biol Chem 274, no. 44 (October 29, 1999): 31515–23. https://doi.org/10.1074/jbc.274.44.31515.Full Text Link to Item
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Gainetdinov, R. R., and M. G. Caron. “Delineating muscarinic receptor functions.” Proc Natl Acad Sci U S A 96, no. 22 (October 26, 1999): 12222–23. https://doi.org/10.1073/pnas.96.22.12222.Full Text Link to Item
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Jaber, M., B. Dumartin, C. Sagné, J. W. Haycock, C. Roubert, B. Giros, B. Bloch, and M. G. Caron. “Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter.” Eur J Neurosci 11, no. 10 (October 1999): 3499–3511. https://doi.org/10.1046/j.1460-9568.1999.00764.x.Full Text Link to Item
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Miller, G. W., R. R. Gainetdinov, A. I. Levey, and M. G. Caron. “Dopamine transporters and neuronal injury.” Trends Pharmacol Sci 20, no. 10 (October 1999): 424–29. https://doi.org/10.1016/s0165-6147(99)01379-6.Full Text Link to Item
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Mohn, A. R., R. R. Gainetdinov, M. G. Caron, and B. H. Koller. “Mice with reduced NMDA receptor expression display behaviors related to schizophrenia.” Cell 98, no. 4 (August 20, 1999): 427–36. https://doi.org/10.1016/s0092-8674(00)81972-8.Full Text Link to Item
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Gainetdinov, R. R., S. R. Jones, and M. G. Caron. “Functional hyperdopaminergia in dopamine transporter knock-out mice.” Biol Psychiatry 46, no. 3 (August 1, 1999): 303–11. https://doi.org/10.1016/s0006-3223(99)00122-5.Full Text Link to Item
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Jones, S. R., R. R. Gainetdinov, X. T. Hu, D. C. Cooper, R. M. Wightman, F. J. White, and M. G. Caron. “Loss of autoreceptor functions in mice lacking the dopamine transporter.” Nat Neurosci 2, no. 7 (July 1999): 649–55. https://doi.org/10.1038/10204.Full Text Link to Item
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Campbell, K. M., L. de Lecea, D. M. Severynse, M. G. Caron, M. J. McGrath, S. B. Sparber, L. Y. Sun, and F. H. Burton. “OCD-Like behaviors caused by a neuropotentiating transgene targeted to cortical and limbic D1+ neurons.” J Neurosci 19, no. 12 (June 15, 1999): 5044–53.Link to Item
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Gainetdinov, R. R., and M. G. Caron. “Genetic models in pharmacology: present status and future.” Pharmacol Res 39, no. 6 (June 1999): 403–4. https://doi.org/10.1006/phrs.1999.0498.Full Text Link to Item
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Ralph, R. J., G. B. Varty, M. A. Kelly, Y. M. Wang, M. G. Caron, M. Rubinstein, D. K. Grandy, M. J. Low, and M. A. Geyer. “The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice.” J Neurosci 19, no. 11 (June 1, 1999): 4627–33.Link to Item
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Zhang, J., L. S. Barak, P. H. Anborgh, S. A. Laporte, M. G. Caron, and S. S. Ferguson. “Cellular trafficking of G protein-coupled receptor/beta-arrestin endocytic complexes.” J Biol Chem 274, no. 16 (April 16, 1999): 10999–6. https://doi.org/10.1074/jbc.274.16.10999.Full Text Link to Item
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Fumagalli, F., R. R. Gainetdinov, Y. M. Wang, K. J. Valenzano, G. W. Miller, and M. G. Caron. “Increased methamphetamine neurotoxicity in heterozygous vesicular monoamine transporter 2 knock-out mice.” J Neurosci 19, no. 7 (April 1, 1999): 2424–31.Link to Item
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Walker, J. K., K. Peppel, R. J. Lefkowitz, M. G. Caron, and J. T. Fisher. “Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3.” Am J Physiol 276, no. 4 (April 1999): R1214–21. https://doi.org/10.1152/ajpregu.1999.276.4.R1214.Full Text Link to Item
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Laporte, S. A., R. H. Oakley, J. Zhang, J. A. Holt, S. S. Ferguson, M. G. Caron, and L. S. Barak. “The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis.” Proc Natl Acad Sci U S A 96, no. 7 (March 30, 1999): 3712–17. https://doi.org/10.1073/pnas.96.7.3712.Full Text Link to Item
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Barak, L. S., K. Warabi, X. Feng, M. G. Caron, and M. M. Kwatra. “Real-time visualization of the cellular redistribution of G protein-coupled receptor kinase 2 and beta-arrestin 2 during homologous desensitization of the substance P receptor.” J Biol Chem 274, no. 11 (March 12, 1999): 7565–69. https://doi.org/10.1074/jbc.274.11.7565.Full Text Link to Item
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Mhaouty-Kodja, S., L. S. Barak, A. Scheer, L. Abuin, D. Diviani, M. G. Caron, and S. Cotecchia. “Constitutively active alpha-1b adrenergic receptor mutants display different phosphorylation and internalization features.” Mol Pharmacol 55, no. 2 (February 1999): 339–47. https://doi.org/10.1124/mol.55.2.339.Full Text Link to Item
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Luttrell, L. M., S. S. Ferguson, Y. Daaka, W. E. Miller, S. Maudsley, G. J. Della Rocca, F. Lin, et al. “Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.” Science 283, no. 5402 (January 29, 1999): 655–61. https://doi.org/10.1126/science.283.5402.655.Full Text Link to Item
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Gainetdinov, R. R., W. C. Wetsel, S. R. Jones, E. D. Levin, M. Jaber, and M. G. Caron. “Role of serotonin in the paradoxical calming effect of psychostimulants on hyperactivity.” Science 283, no. 5400 (January 15, 1999): 397–401. https://doi.org/10.1126/science.283.5400.397.Full Text Link to Item
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Barak, L. S., J. Zhang, S. S. Ferguson, S. A. Laporte, and M. G. Caron. “Signaling, desensitization, and trafficking of G protein-coupled receptors revealed by green fluorescent protein conjugates.” Methods Enzymol 302 (1999): 153–71. https://doi.org/10.1016/s0076-6879(99)02016-9.Full Text Link to Item
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Zhang, J., S. S. Ferguson, P. Y. Law, L. S. Barak, and M. G. Caron. “Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin.” J Recept Signal Transduct Res 19, no. 1–4 (January 1999): 301–13. https://doi.org/10.3109/10799899909036653.Full Text Link to Item
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Cases, O., C. Lebrand, B. Giros, T. Vitalis, E. De Maeyer, M. G. Caron, D. J. Price, P. Gaspar, and I. Seif. “Plasma membrane transporters of serotonin, dopamine, and norepinephrine mediate serotonin accumulation in atypical locations in the developing brain of monoamine oxidase A knock-outs.” J Neurosci 18, no. 17 (September 1, 1998): 6914–27.Link to Item
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Rockman, H. A., D. J. Choi, S. A. Akhter, M. Jaber, B. Giros, R. J. Lefkowitz, M. G. Caron, and W. J. Koch. “Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice.” J Biol Chem 273, no. 29 (July 17, 1998): 18180–84. https://doi.org/10.1074/jbc.273.29.18180.Full Text Link to Item
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Fumagalli, F., R. R. Gainetdinov, K. J. Valenzano, and M. G. Caron. “Role of dopamine transporter in methamphetamine-induced neurotoxicity: evidence from mice lacking the transporter.” J Neurosci 18, no. 13 (July 1, 1998): 4861–69.Link to Item
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Zhang, J., S. S. Ferguson, L. S. Barak, S. R. Bodduluri, S. A. Laporte, P. Y. Law, and M. G. Caron. “Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness.” Proc Natl Acad Sci U S A 95, no. 12 (June 9, 1998): 7157–62. https://doi.org/10.1073/pnas.95.12.7157.Full Text Link to Item
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Rocha, B. A., F. Fumagalli, R. R. Gainetdinov, S. R. Jones, R. Ator, B. Giros, G. W. Miller, and M. G. Caron. “Cocaine self-administration in dopamine-transporter knockout mice.” Nat Neurosci 1, no. 2 (June 1998): 132–37. https://doi.org/10.1038/381.Full Text Link to Item
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Pitcher, J. A., R. A. Hall, Y. Daaka, J. Zhang, S. S. Ferguson, S. Hester, S. Miller, M. G. Caron, R. J. Lefkowitz, and L. S. Barak. “The G protein-coupled receptor kinase 2 is a microtubule-associated protein kinase that phosphorylates tubulin.” J Biol Chem 273, no. 20 (May 15, 1998): 12316–24. https://doi.org/10.1074/jbc.273.20.12316.Full Text Link to Item
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Gainetdinov, R. R., F. Fumagalli, Y. M. Wang, S. R. Jones, A. I. Levey, G. W. Miller, and M. G. Caron. “Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice.” J Neurochem 70, no. 5 (May 1998): 1973–78. https://doi.org/10.1046/j.1471-4159.1998.70051973.x.Full Text Link to Item
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Gainetdinov, R. R., S. R. Jones, F. Fumagalli, R. M. Wightman, and M. G. Caron. “Re-evaluation of the role of the dopamine transporter in dopamine system homeostasis.” Brain Res Brain Res Rev 26, no. 2–3 (May 1998): 148–53. https://doi.org/10.1016/s0165-0173(97)00063-5.Full Text Link to Item
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Feng, X., J. Zhang, L. S. Barak, T. Meyer, M. G. Caron, and Y. A. Hannun. “Visualization of dynamic trafficking of a protein kinase C betaII/green fluorescent protein conjugate reveals differences in G protein-coupled receptor activation and desensitization.” J Biol Chem 273, no. 17 (April 24, 1998): 10755–62. https://doi.org/10.1074/jbc.273.17.10755.Full Text Link to Item
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Ferguson, S. S., and M. G. Caron. “G protein-coupled receptor adaptation mechanisms.” Semin Cell Dev Biol 9, no. 2 (April 1998): 119–27. https://doi.org/10.1006/scdb.1997.0216.Full Text Link to Item
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Jones, S. R., R. R. Gainetdinov, M. Jaber, B. Giros, R. M. Wightman, and M. G. Caron. “Profound neuronal plasticity in response to inactivation of the dopamine transporter.” Proc Natl Acad Sci U S A 95, no. 7 (March 31, 1998): 4029–34. https://doi.org/10.1073/pnas.95.7.4029.Full Text Link to Item
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Shetzline, M. A., R. T. Premont, J. K. Walker, S. R. Vigna, and M. G. Caron. “A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor.” J Biol Chem 273, no. 12 (March 20, 1998): 6756–62. https://doi.org/10.1074/jbc.273.12.6756.Full Text Link to Item
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Jones, S. R., R. R. Gainetdinov, R. M. Wightman, and M. G. Caron. “Mechanisms of amphetamine action revealed in mice lacking the dopamine transporter.” J Neurosci 18, no. 6 (March 15, 1998): 1979–86.Link to Item
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Daaka, Y., L. M. Luttrell, S. Ahn, G. J. Della Rocca, S. S. Ferguson, M. G. Caron, and R. J. Lefkowitz. “Essential role for G protein-coupled receptor endocytosis in the activation of mitogen-activated protein kinase.” J Biol Chem 273, no. 2 (January 9, 1998): 685–88. https://doi.org/10.1074/jbc.273.2.685.Full Text Link to Item
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Ferguson, S. S., J. Zhang, L. S. Barak, and M. G. Caron. “Role of beta-arrestins in the intracellular trafficking of G-protein-coupled receptors.” Adv Pharmacol 42 (1998): 420–24. https://doi.org/10.1016/s1054-3589(08)60778-4.Full Text Link to Item
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Ferguson, S. S., J. Zhang, L. S. Barak, and M. G. Caron. “Molecular mechanisms of G protein-coupled receptor desensitization and resensitization.” Life Sci 62, no. 17–18 (1998): 1561–65. https://doi.org/10.1016/s0024-3205(98)00107-6.Full Text Link to Item
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Fumagalli, F., S. Jones, R. Bossé, M. Jaber, B. Giros, C. Missale, R. M. Wightman, and M. G. Caron. “Inactivation of the dopamine transporter reveals essential roles of dopamine in the control of locomotion, psychostimulant response, and pituitary function.” Adv Pharmacol 42 (1998): 179–82. https://doi.org/10.1016/s1054-3589(08)60722-x.Full Text Link to Item
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Jaber, M., B. Bloch, M. G. Caron, and B. Giros. “[Behavioral, cellular and molecular consequences of the dopamine transporter gene inactivation].” C R Seances Soc Biol Fil 192, no. 6 (1998): 1127–37.Link to Item
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Missale, C., S. R. Nash, S. W. Robinson, M. Jaber, and M. G. Caron. “Dopamine receptors: from structure to function.” Physiol Rev 78, no. 1 (January 1998): 189–225. https://doi.org/10.1152/physrev.1998.78.1.189.Full Text Link to Item
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Nash, S. R., B. Giros, S. F. Kingsmore, K. M. Kim, S. el-Mestikawy, Q. Dong, F. Fumagalli, M. F. Seldin, and M. G. Caron. “Cloning, gene structure and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms.” Recept Channels 6, no. 2 (1998): 113–28.Link to Item
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Walker, J. K. L., K. Peppel, R. J. Lefkowitz, M. G. Caron, and J. T. Fisher. “Altered cardiac chronotropic responses in βARK 2 knockout mice.” Faseb Journal 12, no. 4 (1998): A396.
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Wang, Y. M., R. R. Gainetdinov, F. Fumagalli, F. Xu, S. R. Jones, C. B. Bock, G. W. Miller, R. M. Wightman, and M. G. Caron. “Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine.” Neuron 19, no. 6 (December 1997): 1285–96. https://doi.org/10.1016/s0896-6273(00)80419-5.Full Text Link to Item
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Barak, L. S., S. S. Ferguson, J. Zhang, and M. G. Caron. “A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation.” J Biol Chem 272, no. 44 (October 31, 1997): 27497–500. https://doi.org/10.1074/jbc.272.44.27497.Full Text Link to Item
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Zhang, J., L. S. Barak, K. E. Winkler, M. G. Caron, and S. S. Ferguson. “A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types.” J Biol Chem 272, no. 43 (October 24, 1997): 27005–14. https://doi.org/10.1074/jbc.272.43.27005.Full Text Link to Item
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Peppel, K., I. Boekhoff, P. McDonald, H. Breer, M. G. Caron, and R. J. Lefkowitz. “G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization.” J Biol Chem 272, no. 41 (October 10, 1997): 25425–28. https://doi.org/10.1074/jbc.272.41.25425.Full Text Link to Item
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Gainetdinov, R. R., F. Fumagalli, S. R. Jones, and M. G. Caron. “Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter.” J Neurochem 69, no. 3 (September 1997): 1322–25. https://doi.org/10.1046/j.1471-4159.1997.69031322.x.Full Text Link to Item
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Jaber, M., S. Jones, B. Giros, and M. G. Caron. “The dopamine transporter: a crucial component regulating dopamine transmission.” Mov Disord 12, no. 5 (September 1997): 629–33. https://doi.org/10.1002/mds.870120502.Full Text Link to Item
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Robinson, S. W., and M. G. Caron. “Selective inhibition of adenylyl cyclase type V by the dopamine D3 receptor.” Mol Pharmacol 52, no. 3 (September 1997): 508–14. https://doi.org/10.1124/mol.52.3.508.Full Text Link to Item
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Aramori, I., S. S. Ferguson, P. D. Bieniasz, J. Zhang, B. Cullen, and M. G. Cullen. “Molecular mechanism of desensitization of the chemokine receptor CCR-5: receptor signaling and internalization are dissociable from its role as an HIV-1 co-receptor.” Embo J 16, no. 15 (August 1, 1997): 4606–16. https://doi.org/10.1093/emboj/16.15.4606.Full Text Link to Item
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Bossé, R., F. Fumagalli, M. Jaber, B. Giros, R. R. Gainetdinov, W. C. Wetsel, C. Missale, and M. G. Caron. “Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter.” Neuron 19, no. 1 (July 1997): 127–38. https://doi.org/10.1016/s0896-6273(00)80353-0.Full Text Link to Item
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Bieniasz, P. D., R. A. Fridell, I. Aramori, S. S. Ferguson, M. G. Caron, and B. R. Cullen. “HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor.” Embo J 16, no. 10 (May 15, 1997): 2599–2609. https://doi.org/10.1093/emboj/16.10.2599.Full Text Link to Item
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Ménard, L., S. S. Ferguson, J. Zhang, F. T. Lin, R. J. Lefkowitz, M. G. Caron, and L. S. Barak. “Synergistic regulation of beta2-adrenergic receptor sequestration: intracellular complement of beta-adrenergic receptor kinase and beta-arrestin determine kinetics of internalization.” Mol Pharmacol 51, no. 5 (May 1997): 800–808.Link to Item
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Barak, L. S., S. S. Ferguson, J. Zhang, C. Martenson, T. Meyer, and M. G. Caron. “Internal trafficking and surface mobility of a functionally intact beta2-adrenergic receptor-green fluorescent protein conjugate.” Mol Pharmacol 51, no. 2 (February 1997): 177–84. https://doi.org/10.1124/mol.51.2.177.Full Text Link to Item
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Silvia, C. P., M. Jaber, G. R. King, E. H. Ellinwood, and M. G. Caron. “Cocaine and amphetamine elicit differential effects in rats with a unilateral injection of dopamine transporter antisense oligodeoxynucleotides.” Neuroscience 76, no. 3 (February 1997): 737–47. https://doi.org/10.1016/s0306-4522(96)00399-5.Full Text Link to Item
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Ferguson, S. S. G., J. Zhang, L. S. Barak, and M. G. Caron. “Pleiotropic role for GRKs and β-arrestins in receptor regulation.” News in Physiological Sciences 12, no. 4 (January 1, 1997): 145–51. https://doi.org/10.1152/physiologyonline.1997.12.4.145.Full Text
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Zhang, J., S. S. Ferguson, L. S. Barak, M. J. Aber, B. Giros, R. J. Lefkowitz, and M. G. Caron. “Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization.” Recept Channels 5, no. 3–4 (1997): 193–99.Link to Item
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Caron, M. G. “Images in neuroscience. Molecular biology, II. A dopamine transporter mouse knockout.” Am J Psychiatry 153, no. 12 (December 1996): 1515. https://doi.org/10.1176/ajp.153.12.1515.Full Text Link to Item
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Jaber, M., W. J. Koch, H. Rockman, B. Smith, R. A. Bond, K. K. Sulik, J. Ross, R. J. Lefkowitz, M. G. Caron, and B. Giros. “Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function.” Proc Natl Acad Sci U S A 93, no. 23 (November 12, 1996): 12974–79. https://doi.org/10.1073/pnas.93.23.12974.Full Text Open Access Copy Link to Item
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Charpentier, S., K. R. Jarvie, D. M. Severynse, M. G. Caron, and M. Tiberi. “Silencing of the constitutive activity of the dopamine D1B receptor. Reciprocal mutations between D1 receptor subtypes delineate residues underlying activation properties.” J Biol Chem 271, no. 45 (November 8, 1996): 28071–76. https://doi.org/10.1074/jbc.271.45.28071.Full Text Link to Item
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Caron, M. G. “Images in neuroscience. A mouse knockout.” Am J Psychiatry 153, no. 11 (November 1996): 1387. https://doi.org/10.1176/ajp.153.11.1387.Full Text Link to Item
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Ferguson, S. S., J. Zhang, L. S. Barak, and M. G. Caron. “G-protein-coupled receptor kinases and arrestins: regulators of G-protein-coupled receptor sequestration.” Biochem Soc Trans 24, no. 4 (November 1996): 953–59. https://doi.org/10.1042/bst0240953.Full Text Link to Item
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Ferguson, S. S., L. S. Barak, J. Zhang, and M. G. Caron. “G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins.” Can J Physiol Pharmacol 74, no. 10 (October 1996): 1095–1110. https://doi.org/10.1139/cjpp-74-10-1095.Full Text Link to Item
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Zhang, J., S. S. Ferguson, L. S. Barak, L. Ménard, and M. G. Caron. “Dynamin and beta-arrestin reveal distinct mechanisms for G protein-coupled receptor internalization.” J Biol Chem 271, no. 31 (August 2, 1996): 18302–5. https://doi.org/10.1074/jbc.271.31.18302.Full Text Link to Item
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Robinson, S. W., and M. G. Caron. “Chimeric D2/D3 dopamine receptors efficiently inhibit adenylyl cyclase in HEK 293 cells.” J Neurochem 67, no. 1 (July 1996): 212–19. https://doi.org/10.1046/j.1471-4159.1996.67010212.x.Full Text Link to Item
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Brana, C., I. Caille, C. Pellevoisin, G. Charron, I. Aubert, M. G. Caron, D. Carles, C. Vital, and B. Bloch. “Ontogeny of the striatal neurons expressing the D1 dopamine receptor in humans.” J Comp Neurol 370, no. 1 (June 17, 1996): 23–34. https://doi.org/10.1002/(SICI)1096-9861(19960617)370:1<23::AID-CNE3>3.0.CO;2-N.Full Text Link to Item
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Pifl, C., O. Hornykiewicz, B. Giros, and M. G. Caron. “Catecholamine transporters and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: studies comparing the cloned human noradrenaline and human dopamine transporter.” J Pharmacol Exp Ther 277, no. 3 (June 1996): 1437–43.Link to Item
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Fumagalli, F., S. R. Jones, M. G. Caron, F. J. Seidler, and T. A. Slotkin. “Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids.” Brain Res 719, no. 1–2 (May 6, 1996): 225–28. https://doi.org/10.1016/0006-8993(96)00119-9.Full Text Link to Item
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Ménard, L., S. S. Ferguson, L. S. Barak, L. Bertrand, R. T. Premont, A. M. Colapietro, R. J. Lefkowitz, and M. G. Caron. “Members of the G protein-coupled receptor kinase family that phosphorylate the beta2-adrenergic receptor facilitate sequestration.” Biochemistry 35, no. 13 (April 2, 1996): 4155–60. https://doi.org/10.1021/bi952961+.Full Text Link to Item
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Tiberi, M., S. R. Nash, L. Bertrand, R. J. Lefkowitz, and M. G. Caron. “Differential regulation of dopamine D1A receptor responsiveness by various G protein-coupled receptor kinases.” J Biol Chem 271, no. 7 (February 16, 1996): 3771–78. https://doi.org/10.1074/jbc.271.7.3771.Full Text Link to Item
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Giros, B., M. Jaber, S. R. Jones, R. M. Wightman, and M. G. Caron. “Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter.” Nature 379, no. 6566 (February 15, 1996): 606–12. https://doi.org/10.1038/379606a0.Full Text Link to Item
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Ferguson, S. S., W. E. Downey, A. M. Colapietro, L. S. Barak, L. Ménard, and M. G. Caron. “Role of beta-arrestin in mediating agonist-promoted G protein-coupled receptor internalization.” Science 271, no. 5247 (January 19, 1996): 363–66. https://doi.org/10.1126/science.271.5247.363.Full Text Link to Item
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Jaber, M., S. W. Robinson, C. Missale, and M. G. Caron. “Dopamine receptors and brain function.” Neuropharmacology 35, no. 11 (1996): 1503–19. https://doi.org/10.1016/s0028-3908(96)00100-1.Full Text Link to Item
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Pifl, C., B. Giros, and M. G. Caron. “The dopamine transporter. The cloned target site of parkinsonism-inducing toxins and of drugs of abuse.” Adv Neurol 69 (1996): 235–38.Link to Item
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Sizmann, D., H. Kuusinen, S. Keränen, J. Lomasney, M. G. Caron, R. J. Lefkowitz, and K. Keinänen. “Production of adrenergic receptors in yeast.” Recept Channels 4, no. 3 (1996): 197–203.Link to Item
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Tamminga, C. A., and M. G. Caron. “A mouse knockout.” American Journal of Psychiatry 153, no. 11 (January 1, 1996): 1387.
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Kwatra, M. M., J. Schreurs, D. A. Schwinn, M. A. Innis, M. G. Caron, and R. J. Lefkowitz. “Immunoaffinity purification of epitope-tagged human beta 2-adrenergic receptor to homogeneity.” Protein Expr Purif 6, no. 6 (December 1995): 717–21. https://doi.org/10.1006/prep.1995.0001.Full Text Link to Item
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Barak, L. S., L. Ménard, S. S. Ferguson, A. M. Colapietro, and M. G. Caron. “The conserved seven-transmembrane sequence NP(X)2,3Y of the G-protein-coupled receptor superfamily regulates multiple properties of the beta 2-adrenergic receptor.” Biochemistry 34, no. 47 (November 28, 1995): 15407–14. https://doi.org/10.1021/bi00047a003.Full Text Link to Item
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Ferguson, S. S., L. Ménard, L. S. Barak, W. J. Koch, A. M. Colapietro, and M. G. Caron. “Role of phosphorylation in agonist-promoted beta 2-adrenergic receptor sequestration. Rescue of a sequestration-defective mutant receptor by beta ARK1.” J Biol Chem 270, no. 42 (October 20, 1995): 24782–89. https://doi.org/10.1074/jbc.270.42.24782.Full Text Link to Item
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Freedman, N. J., S. B. Liggett, D. E. Drachman, G. Pei, M. G. Caron, and R. J. Lefkowitz. “Phosphorylation and desensitization of the human beta 1-adrenergic receptor. Involvement of G protein-coupled receptor kinases and cAMP-dependent protein kinase.” J Biol Chem 270, no. 30 (July 28, 1995): 17953–61. https://doi.org/10.1074/jbc.270.30.17953.Full Text Link to Item
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Severynse, D. M., A. M. Colapietro, T. L. Box, and M. G. Caron. “The human D1A dopamine receptor gene promoter directs expression of a reporter gene to the central nervous system in transgenic mice.” Brain Res Mol Brain Res 30, no. 2 (June 1995): 336–46. https://doi.org/10.1016/0169-328x(95)00023-l.Full Text Link to Item
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Moroi-Fetters, S. E., O. Earley, A. Hirakata, M. G. Caron, and G. J. Jaffe. “Binding, coupling, and mRNA subtype heterogeneity of alpha 1-adrenergic receptors in cultured human RPE.” Exp Eye Res 60, no. 5 (May 1995): 527–32. https://doi.org/10.1016/s0014-4835(05)80067-3.Full Text Link to Item
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Kingsmore, S. F., K. Peppel, D. Suh, M. G. Caron, R. J. Lefkowitz, and M. F. Seldin. “Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively.” Mamm Genome 6, no. 4 (April 1995): 306–7. https://doi.org/10.1007/BF00352426.Full Text Link to Item
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Barak, L. S., and M. G. Caron. “Modeling of sequestration and down regulation in cells containing beta2-adrenergic receptors.” J Recept Signal Transduct Res 15, no. 1–4 (January 1995): 677–90. https://doi.org/10.3109/10799899509045248.Full Text Link to Item
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Gregor, P., S. R. Nash, M. G. Caron, M. F. Seldin, and S. T. Warren. “Assignment of the creatine transporter gene (SLC6A8) to human chromosome Xq28 telomeric to G6PD.” Genomics 25, no. 1 (January 1, 1995): 332–33. https://doi.org/10.1016/0888-7543(95)80155-f.Full Text Link to Item
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Kleber, H. D., C. A. Tamminga, C. A. Schreur, P. Willner, M. F. Piercey, M. G. Caron, and R. A. Wise. “Pharmacotherapy, current and potential, for the treatment of cocaine dependence.” Clinical Neuropharmacology 18, no. SUPPL. 1 (January 1, 1995). https://doi.org/10.1097/00002826-199501001-00012.Full Text
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Lajiness, M. E., C. L. Chio, R. M. Huff, M. G. Caron, C. A. Tamminga, H. H. M. V. Tol, A. Carlsson, J. C. Schwartz, and M. F. Piercey. “Signaling mechanisms of D2, D3, and D4 dopamine receptors determined in transfected cell lines.” Clinical Neuropharmacology 18, no. SUPPL. 1 (1995): S25–33.
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Meador-Woodruff, J. H., M. G. Caron, A. Carlsson, M. F. Piercey, P. J. Bedard, and H. H. M. Van Tol. “Neuroanatomy of dopamine receptor gene expression: Potential substrates for neuropsychiatric illness.” Clinical Neuropharmacology 18, no. SUPPL. 1 (January 1, 1995). https://doi.org/10.1097/00002826-199501001-00003.Full Text
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Piercey, M. F., M. Camacho-Ochoa, M. W. Smith, M. G. Caron, P. J. Bedard, and P. Willner. “Functional roles for dopamine-receptor subtypes.” Clinical Neuropharmacology 18, no. SUPPL. 1 (January 1, 1995). https://doi.org/10.1097/00002826-199501001-00005.Full Text
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Tiberi, M., M. G. Caron, and A. Carlsson. “Constitutive activity of dopamine D1- receptor subtypes.” Clinical Neuropharmacology 18, no. SUPPL. 1 (January 1, 1995). https://doi.org/10.1097/00002826-199501001-00006.Full Text
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Snaprud, P., P. Gerwins, M. G. Caron, F. Libert, H. Persson, B. B. Fredholm, and K. Fuxe. “A2a/D2 receptor interactions are not observed in COS-7 cells transiently transfected with dopamine D2 and adenosine A2a receptor cDNA.” Biochem Pharmacol 48, no. 11 (November 29, 1994): 2043–47. https://doi.org/10.1016/0006-2952(94)90503-7.Full Text Link to Item
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Tiberi, M., and M. G. Caron. “High agonist-independent activity is a distinguishing feature of the dopamine D1B receptor subtype.” J Biol Chem 269, no. 45 (November 11, 1994): 27925–31.Link to Item
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Schambra, U. B., G. E. Duncan, G. R. Breese, M. G. Fornaretto, M. G. Caron, and R. T. Fremeau. “Ontogeny of D1A and D2 dopamine receptor subtypes in rat brain using in situ hybridization and receptor binding.” Neuroscience 62, no. 1 (September 1994): 65–85. https://doi.org/10.1016/0306-4522(94)90315-8.Full Text Link to Item
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Robinson, S. W., K. R. Jarvie, and M. G. Caron. “High affinity agonist binding to the dopamine D3 receptor: chimeric receptors delineate a role for intracellular domains.” Mol Pharmacol 46, no. 2 (August 1994): 352–56.Link to Item
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Silvia, C. P., G. R. King, T. H. Lee, Z. Y. Xue, M. G. Caron, and E. H. Ellinwood. “Intranigral administration of D2 dopamine receptor antisense oligodeoxynucleotides establishes a role for nigrostriatal D2 autoreceptors in the motor actions of cocaine.” Mol Pharmacol 46, no. 1 (July 1994): 51–57.Link to Item
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Giros, B., Y. M. Wang, S. Suter, S. B. McLeskey, C. Pifl, and M. G. Caron. “Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters.” J Biol Chem 269, no. 23 (June 10, 1994): 15985–88.Link to Item
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Kingsmore, S. F., B. Giros, D. Suh, M. Bieniarz, M. G. Caron, and M. F. Seldin. “Glycine receptor beta-subunit gene mutation in spastic mouse associated with LINE-1 element insertion.” Nat Genet 7, no. 2 (June 1994): 136–41. https://doi.org/10.1038/ng0694-136.Full Text Link to Item
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King, G. R., E. H. Ellinwood, C. Silvia, C. M. Joyner, Z. Xue, M. G. Caron, and T. H. Lee. “Withdrawal from continuous or intermittent cocaine administration: changes in D2 receptor function.” J Pharmacol Exp Ther 269, no. 2 (May 1994): 743–49.Link to Item
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Pei, G., M. Tiberi, M. G. Caron, and R. J. Lefkowitz. “An approach to the study of G-protein-coupled receptor kinases: an in vitro-purified membrane assay reveals differential receptor specificity and regulation by G beta gamma subunits.” Proc Natl Acad Sci U S A 91, no. 9 (April 26, 1994): 3633–36. https://doi.org/10.1073/pnas.91.9.3633.Full Text Open Access Copy Link to Item
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Kim, K. M., S. F. Kingsmore, H. Han, T. L. Yang-Feng, N. Godinot, M. F. Seldin, M. G. Caron, and B. Giros. “Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes.” Mol Pharmacol 45, no. 4 (April 1994): 608–17.Link to Item
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Li, T., L. Yang, C. Wiese, C. T. Xu, Z. Zeng, B. Giros, M. G. Caron, H. W. Moises, and X. Liu. “No association between alleles or genotypes at the dopamine transporter gene and schizophrenia.” Psychiatry Res 52, no. 1 (April 1994): 17–23. https://doi.org/10.1016/0165-1781(94)90116-3.Full Text Link to Item
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Missale, C., F. Boroni, S. Sigala, L. Castelletti, P. Falardeau, R. Dal Toso, M. G. Caron, and P. Spano. “Epidermal growth factor promotes uncoupling from adenylyl cyclase of the rat D2S receptor expressed in GH4C1 cells.” J Neurochem 62, no. 3 (March 1994): 907–15. https://doi.org/10.1046/j.1471-4159.1994.62030907.x.Full Text Link to Item
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Mestikawy, S. el, B. Giros, M. Pohl, M. Hamon, S. F. Kingsmore, M. F. Seldin, and M. G. Caron. “Characterization of an atypical member of the Na+/Cl(-)-dependent transporter family: chromosomal localization and distribution in GABAergic and glutamatergic neurons in the rat brain.” J Neurochem 62, no. 2 (February 1994): 445–55. https://doi.org/10.1046/j.1471-4159.1994.62020445.x.Full Text Link to Item
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Price, D. T., R. J. Lefkowitz, M. G. Caron, D. Berkowitz, and D. A. Schwinn. “Localization of mRNA for three distinct alpha 1-adrenergic receptor subtypes in human tissues: implications for human alpha-adrenergic physiology.” Mol Pharmacol 45, no. 2 (February 1994): 171–75.Link to Item
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Barak, L. S., M. Tiberi, N. J. Freedman, M. M. Kwatra, R. J. Lefkowitz, and M. G. Caron. “A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.” J Biol Chem 269, no. 4 (January 28, 1994): 2790–95.Link to Item
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Kwatra, M. M., R. J. Lefkowitz, and M. G. Caron. “Partially purified and reconstituted g-protein coupled receptors as substrates of specific receptor kinases.” Methods 6, no. 1 (January 1, 1994): 11–17. https://doi.org/10.1006/meth.1994.1003.Full Text
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Nash, S. R., B. Giros, S. F. Kingsmore, J. M. Rochelle, S. T. Suter, P. Gregor, M. F. Seldin, and M. G. Caron. “Cloning, pharmacological characterization, and genomic localization of the human creatine transporter.” Recept Channels 2, no. 2 (1994): 165–74.Link to Item
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Scheinin, M., J. W. Lomasney, D. M. Hayden-Hixson, U. B. Schambra, M. G. Caron, R. J. Lefkowitz, and R. T. Fremeau. “Distribution of alpha 2-adrenergic receptor subtype gene expression in rat brain.” Brain Res Mol Brain Res 21, no. 1–2 (January 1994): 133–49. https://doi.org/10.1016/0169-328x(94)90386-7.Full Text Link to Item
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Snaprud, P., P. Gerwins, M. G. Caron, F. Libert, H. Persson, B. B. Fredholm, and K. Fuxe. “A2a/D2 receptor interactions are not observed in COS-7 cells transiently transfected with dopamine D2 and adenosine A2a receptor cDNA.” Biochemical Pharmacology 48, no. 11 (1994): 2043–47.
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Yang-Feng, T. L., H. Han, J. W. Lomasney, and M. G. Caron. “Localization of the cDNA for an alpha 1-adrenergic receptor subtype (ADRA1D) to chromosome band 20p13.” Cytogenet Cell Genet 66, no. 3 (1994): 170–71. https://doi.org/10.1159/000133693.Full Text Link to Item
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Caron, M. G. “Molecular neurobiology. The chimaeras speak again.” Nature 366, no. 6454 (December 2, 1993): 409. https://doi.org/10.1038/366409a0.Full Text Link to Item
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Nash, S. R., N. Godinot, and M. G. Caron. “Cloning and characterization of the opossum kidney cell D1 dopamine receptor: expression of identical D1A and D1B dopamine receptor mRNAs in opossum kidney and brain.” Mol Pharmacol 44, no. 5 (November 1993): 918–25.Link to Item
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Duncan, G. E., G. R. Breese, H. E. Criswell, K. B. Johnson, U. B. Schambra, R. A. Mueller, M. G. Caron, and R. T. Fremeau. “D1 dopamine receptor binding and mRNA levels are not altered after neonatal 6-hydroxydopamine treatment: evidence against dopamine-mediated induction of D1 dopamine receptors during postnatal development.” J Neurochem 61, no. 4 (October 1993): 1255–62. https://doi.org/10.1111/j.1471-4159.1993.tb13616.x.Full Text Link to Item
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Pifl, C., B. Giros, and M. G. Caron. “Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium.” J Neurosci 13, no. 10 (October 1993): 4246–53.Link to Item
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Byerley, W., H. Coon, M. Hoff, J. Holik, M. Waldo, R. Freedman, M. G. Caron, and B. Giros. “Human dopamine transporter gene not linked to schizophrenia in multigenerational pedigrees.” Hum Hered 43, no. 5 (September 1993): 319–22. https://doi.org/10.1159/000154151.Full Text Link to Item
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Price, D. T., D. A. Schwinn, J. W. Lomasney, L. F. Allen, M. G. Caron, and R. J. Lefkowitz. “Identification, quantification, and localization of mRNA for three distinct alpha 1 adrenergic receptor subtypes in human prostate.” J Urol 150, no. 2 Pt 1 (August 1993): 546–51. https://doi.org/10.1016/s0022-5347(17)35544-1.Full Text Link to Item
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Kwatra, M. M., D. A. Schwinn, J. Schreurs, J. L. Blank, C. M. Kim, J. L. Benovic, J. E. Krause, M. G. Caron, and R. J. Lefkowitz. “The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2.” J Biol Chem 268, no. 13 (May 5, 1993): 9161–64.Link to Item
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Fornaretto, M. G., C. Caccia, M. G. Caron, and R. G. Fariello. “Dopamine receptors status after unilateral nigral 6-OHDA lesion. Autoradiographic and in situ hybridization study in the rat brain.” Mol Chem Neuropathol 19, no. 1–2 (May 1993): 147–62. https://doi.org/10.1007/BF03160175.Full Text Link to Item
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Blitzer, R. D., G. Omri, M. De Vivo, D. J. Carty, R. T. Premont, J. Codina, L. Birnbaumer, S. Cotecchia, M. G. Caron, and R. J. Lefkowitz. “Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go.” J Biol Chem 268, no. 10 (April 5, 1993): 7532–37.Link to Item
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Byerley, W., M. Hoff, J. Holik, M. G. Caron, and B. Giros. “VNTR polymorphism for the human dopamine transporter gene (DAT1).” Hum Mol Genet 2, no. 3 (March 1993): 335. https://doi.org/10.1093/hmg/2.3.335.Full Text Link to Item
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Pippig, S., S. Andexinger, K. Daniel, M. Puzicha, M. G. Caron, R. J. Lefkowitz, and M. J. Lohse. “Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.” J Biol Chem 268, no. 5 (February 15, 1993): 3201–8.Link to Item
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Giros, B., and M. G. Caron. “Molecular characterization of the dopamine transporter.” Trends Pharmacol Sci 14, no. 2 (February 1993): 43–49. https://doi.org/10.1016/0165-6147(93)90029-j.Full Text Link to Item
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Caron, M. G., and R. J. Lefkowitz. “Catecholamine receptors: structure, function, and regulation.” Recent Prog Horm Res 48 (1993): 277–90. https://doi.org/10.1016/b978-0-12-571148-7.50014-2.Full Text Link to Item
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Duncan, G. E., G. R. Breese, H. E. Criswell, K. B. Johnson, U. B. Schambra, R. A. Mueller, M. G. Caron, and R. T. F. Jr. “D1 dopamine receptor binding and mRNA levels are not altered after neonatal 6-hydroxydopamine treatment: Evidence against dopamine-mediated induction of D1 dopamine receptors during postnatal development.” Journal of Neurochemistry 61, no. 4 (1993): 1255–62.
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Gingrich, J. A., and M. G. Caron. “Recent advances in the molecular biology of dopamine receptors.” Annu Rev Neurosci 16 (1993): 299–321. https://doi.org/10.1146/annurev.ne.16.030193.001503.Full Text Link to Item
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Hausdorff, W. P., J. Sung, M. G. Caron, and R. J. Lefkowitz. “Erratum: Recent molecular analysis of β-adrenergic receptor phosphorylation, sequestration and down regulation (Asia Pacific Journal of Pharmacology 1991; 7:149-158).” Asia Pacific Journal of Pharmacology 8, no. 1 (January 1, 1993): 59.
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Jarvie, K. R., M. Tiberi, C. Silvia, J. A. Gingrich, and M. G. Caron. “Molecular cloning, stable expression and desensitization of the human dopamine D1b/D5 receptor.” J Recept Res 13, no. 1–4 (1993): 573–90. https://doi.org/10.3109/10799899309073680.Full Text Link to Item
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Jarvie, K. R., and M. G. Caron. “Heterogeneity of dopamine receptors.” Adv Neurol 60 (1993): 325–33.Link to Item
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Lefkowitz, R. J., S. Cotecchia, M. A. Kjelsberg, J. Pitcher, W. J. Koch, J. Inglese, and M. G. Caron. “Adrenergic receptors: recent insights into their mechanism of activation and desensitization.” Adv Second Messenger Phosphoprotein Res 28 (1993): 1–9.Link to Item
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Gingrich, J. A., P. H. Andersen, M. Tiberi, S. el Mestikawy, P. N. Jorgensen, R. T. Fremeau, and M. G. Caron. “Identification, characterization, and molecular cloning of a novel transporter-like protein localized to the central nervous system.” Febs Lett 312, no. 2–3 (November 9, 1992): 115–22. https://doi.org/10.1016/0014-5793(92)80917-6.Full Text Link to Item
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Arriza, J. L., T. M. Dawson, R. B. Simerly, L. J. Martin, M. G. Caron, S. H. Snyder, and R. J. Lefkowitz. “The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain.” J Neurosci 12, no. 10 (October 1992): 4045–55.Open Access Copy Link to Item
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Inglese, J., W. J. Koch, M. G. Caron, and R. J. Lefkowitz. “Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases.” Nature 359, no. 6391 (September 10, 1992): 147–50. https://doi.org/10.1038/359147a0.Full Text Link to Item
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Attramadal, H., J. L. Arriza, C. Aoki, T. M. Dawson, J. Codina, M. M. Kwatra, S. H. Snyder, M. G. Caron, and R. J. Lefkowitz. “Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.” J Biol Chem 267, no. 25 (September 5, 1992): 17882–90.Link to Item
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Giros, B., S. el Mestikawy, N. Godinot, K. Zheng, H. Han, T. Yang-Feng, and M. G. Caron. “Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter.” Mol Pharmacol 42, no. 3 (September 1992): 383–90.Link to Item
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Luttrell, D. K., W. P. Hausdorff, J. E. Moyers, T. M. Gilmer, S. J. Parsons, M. G. Caron, and R. J. Lefkowitz. “Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase.” Cell Signal 4, no. 5 (September 1992): 531–41. https://doi.org/10.1016/0898-6568(92)90022-z.Full Text Link to Item
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Pitcher, J. A., J. Inglese, J. B. Higgins, J. L. Arriza, P. J. Casey, C. Kim, J. L. Benovic, M. M. Kwatra, M. G. Caron, and R. J. Lefkowitz. “Role of beta gamma subunits of G proteins in targeting the beta-adrenergic receptor kinase to membrane-bound receptors.” Science 257, no. 5074 (August 28, 1992): 1264–67. https://doi.org/10.1126/science.1325672.Full Text Link to Item
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Bylund, D. B., H. S. Blaxall, L. J. Iversen, M. G. Caron, R. J. Lefkowitz, and J. W. Lomasney. “Pharmacological characteristics of alpha 2-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning.” Mol Pharmacol 42, no. 1 (July 1992): 1–5.Link to Item
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Hausdorff, W. P., J. A. Pitcher, D. K. Luttrell, M. E. Linder, H. Kurose, S. J. Parsons, M. G. Caron, and R. J. Lefkowitz. “Tyrosine phosphorylation of G protein alpha subunits by pp60c-src.” Proc Natl Acad Sci U S A 89, no. 13 (July 1, 1992): 5720–24. https://doi.org/10.1073/pnas.89.13.5720.Full Text Open Access Copy Link to Item
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Fremeau, R. T., M. G. Caron, and R. D. Blakely. “Molecular cloning and expression of a high affinity L-proline transporter expressed in putative glutamatergic pathways of rat brain.” Neuron 8, no. 5 (May 1992): 915–26. https://doi.org/10.1016/0896-6273(92)90206-s.Full Text Link to Item
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Lohse, M. J., S. Andexinger, J. Pitcher, S. Trukawinski, J. Codina, J. P. Faure, M. G. Caron, and R. J. Lefkowitz. “Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.” J Biol Chem 267, no. 12 (April 25, 1992): 8558–64.Link to Item
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Pitcher, J., M. J. Lohse, J. Codina, M. G. Caron, and R. J. Lefkowitz. “Desensitization of the isolated beta 2-adrenergic receptor by beta-adrenergic receptor kinase, cAMP-dependent protein kinase, and protein kinase C occurs via distinct molecular mechanisms.” Biochemistry 31, no. 12 (March 31, 1992): 3193–97. https://doi.org/10.1021/bi00127a021.Full Text Link to Item
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Liggett, S. B., J. Ostrowski, L. C. Chesnut, H. Kurose, J. R. Raymond, M. G. Caron, and R. J. Lefkowitz. “Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism.” J Biol Chem 267, no. 7 (March 5, 1992): 4740–46.Link to Item
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Gingrich, J. A., A. Dearry, P. Falardeau, M. D. Bates, R. T. Fremeau, and M. G. Caron. “Location and molecular cloning of D1 dopamine receptor.” Neurochem Int 20 Suppl (March 1992): 9S-15S. https://doi.org/10.1016/0197-0186(92)90204-5.Full Text Link to Item
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Cotecchia, S., J. Ostrowski, M. A. Kjelsberg, M. G. Caron, and R. J. Lefkowitz. “Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis.” J Biol Chem 267, no. 3 (January 25, 1992): 1633–39.Link to Item
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Inglese, J., J. F. Glickman, W. Lorenz, M. G. Caron, and R. J. Lefkowitz. “Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.” J Biol Chem 267, no. 3 (January 25, 1992): 1422–25.Link to Item
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Kjelsberg, M. A., S. Cotecchia, J. Ostrowski, M. G. Caron, and R. J. Lefkowitz. “Constitutive activation of the alpha 1B-adrenergic receptor by all amino acid substitutions at a single site. Evidence for a region which constrains receptor activation.” J Biol Chem 267, no. 3 (January 25, 1992): 1430–33.Link to Item
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Attramadal, H., J. L. Arriza, C. Aoki, T. M. Dawson, J. Codina, M. M. Kwatra, S. H. Snyder, M. G. Caron, and R. J. Lefkowitz. “β-Arrestin2, a novel member of the arrestin/β-arrestin gene family.” Journal of Biological Chemistry 267, no. 25 (January 1, 1992): 17882–90.
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Collins, S., M. G. Caron, and R. J. Lefkowitz. “From ligand binding to gene expression: new insights into the regulation of G-protein-coupled receptors.” Trends Biochem Sci 17, no. 1 (January 1992): 37–39. https://doi.org/10.1016/0968-0004(92)90425-9.Full Text Link to Item
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Giros, B., S. El Mestikawy, N. Godinot, T. Yang-Feng, and M. G. Caron. “Molecular cloning, pharmacological characterization and genetic studies of the human dopamine transporter.” European Neuropsychopharmacology 2, no. 3 (January 1, 1992): 268–69. https://doi.org/10.1016/0924-977X(92)90103-F.Full Text
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Hausdorff, W. P., J. Sung, M. G. Caron, and R. J. Lefkowitz. “Recent molecular analyses of β-adrenergic receptor phosphorylation, sequestration and down regulation.” Asia Pacific Journal of Pharmacology 7, no. 2 (January 1, 1992): 149–58.
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Lefkowitz, R. J., J. Inglese, W. J. Koch, J. Pitcher, H. Attramadal, and M. G. Caron. “G-protein-coupled receptors: regulatory role of receptor kinases and arrestin proteins.” Cold Spring Harb Symp Quant Biol 57 (1992): 127–33. https://doi.org/10.1101/sqb.1992.057.01.016.Full Text Link to Item
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Ostrowski, J., M. A. Kjelsberg, M. G. Caron, and R. J. Lefkowitz. “Mutagenesis of the beta 2-adrenergic receptor: how structure elucidates function.” Annu Rev Pharmacol Toxicol 32 (1992): 167–83. https://doi.org/10.1146/annurev.pa.32.040192.001123.Full Text Link to Item
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Giros, B., S. el Mestikawy, L. Bertrand, and M. G. Caron. “Cloning and functional characterization of a cocaine-sensitive dopamine transporter.” Febs Lett 295, no. 1–3 (December 16, 1991): 149–54. https://doi.org/10.1016/0014-5793(91)81406-x.Full Text Link to Item
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Allen, L. F., R. J. Lefkowitz, M. G. Caron, and S. Cotecchia. “G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity.” Proc Natl Acad Sci U S A 88, no. 24 (December 15, 1991): 11354–58. https://doi.org/10.1073/pnas.88.24.11354.Full Text Open Access Copy Link to Item
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Blakely, R. D., H. E. Berson, R. T. Fremeau, M. G. Caron, M. M. Peek, H. K. Prince, and C. C. Bradley. “Cloning and expression of a functional serotonin transporter from rat brain.” Nature 354, no. 6348 (November 7, 1991): 66–70. https://doi.org/10.1038/354066a0.Full Text Link to Item
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Schwinn, D. A., S. O. Page, J. P. Middleton, W. Lorenz, S. B. Liggett, K. Yamamoto, E. G. Lapetina, M. G. Caron, R. J. Lefkowitz, and S. Cotecchia. “The alpha 1C-adrenergic receptor: characterization of signal transduction pathways and mammalian tissue heterogeneity.” Mol Pharmacol 40, no. 5 (November 1991): 619–26.Link to Item
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Lomasney, J. W., S. Cotecchia, R. J. Lefkowitz, and M. G. Caron. “Molecular biology of alpha-adrenergic receptors: implications for receptor classification and for structure-function relationships.” Biochim Biophys Acta 1095, no. 2 (October 26, 1991): 127–39. https://doi.org/10.1016/0167-4889(91)90075-9.Full Text Link to Item
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Dearry, A., P. Falardeau, C. Shores, and M. G. Caron. “D2 dopamine receptors in the human retina: cloning of cDNA and localization of mRNA.” Cell Mol Neurobiol 11, no. 5 (October 1991): 437–53. https://doi.org/10.1007/BF00734808.Full Text Link to Item
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Lorenz, W., J. Inglese, K. Palczewski, J. J. Onorato, M. G. Caron, and R. J. Lefkowitz. “The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.” Proc Natl Acad Sci U S A 88, no. 19 (October 1, 1991): 8715–19. https://doi.org/10.1073/pnas.88.19.8715.Full Text Open Access Copy Link to Item
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Tiberi, M., K. R. Jarvie, C. Silvia, P. Falardeau, J. A. Gingrich, N. Godinot, L. Bertrand, T. L. Yang-Feng, R. T. Fremeau, and M. G. Caron. “Cloning, molecular characterization, and chromosomal assignment of a gene encoding a second D1 dopamine receptor subtype: differential expression pattern in rat brain compared with the D1A receptor.” Proc Natl Acad Sci U S A 88, no. 17 (September 1, 1991): 7491–95. https://doi.org/10.1073/pnas.88.17.7491.Full Text Link to Item
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Benovic, J. L., J. J. Onorato, J. L. Arriza, W. C. Stone, M. Lohse, N. A. Jenkins, D. J. Gilbert, N. G. Copeland, M. G. Caron, and R. J. Lefkowitz. “Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family.” J Biol Chem 266, no. 23 (August 15, 1991): 14939–46.Link to Item
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Yang, S. D., J. L. Benovic, Y. L. Fong, M. G. Caron, and R. J. Lefkowitz. “Cyclic phosphorylation-dephosphorylation of rhodopsin in retina by protein kinase FA (the activator of ATP.Mg-dependent protein phosphatase).” Biochem Biophys Res Commun 178, no. 3 (August 15, 1991): 1306–11. https://doi.org/10.1016/0006-291x(91)91036-c.Full Text Link to Item
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Roth, N. S., P. T. Campbell, M. G. Caron, R. J. Lefkowitz, and M. J. Lohse. “Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase.” Proc Natl Acad Sci U S A 88, no. 14 (July 15, 1991): 6201–4. https://doi.org/10.1073/pnas.88.14.6201.Full Text Link to Item
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Bates, M. D., M. G. Caron, and J. R. Raymond. “Desensitization of DA1 dopamine receptors coupled to adenylyl cyclase in opossum kidney cells.” Am J Physiol 260, no. 6 Pt 2 (June 1991): F937–45. https://doi.org/10.1152/ajprenal.1991.260.6.F937.Full Text Link to Item
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Oakey, R. J., M. G. Caron, R. J. Lefkowitz, and M. F. Seldin. “Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution.” Genomics 10, no. 2 (June 1991): 338–44. https://doi.org/10.1016/0888-7543(91)90317-8.Full Text Link to Item
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Onorato, J. J., K. Palczewski, J. W. Regan, M. G. Caron, R. J. Lefkowitz, and J. L. Benovic. “Role of acidic amino acids in peptide substrates of the beta-adrenergic receptor kinase and rhodopsin kinase.” Biochemistry 30, no. 21 (May 28, 1991): 5118–25. https://doi.org/10.1021/bi00235a002.Full Text Link to Item
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Benovic, J. L., W. C. Stone, K. Huebner, C. Croce, M. G. Caron, and R. J. Lefkowitz. “cDNA cloning and chromosomal localization of the human beta-adrenergic receptor kinase.” Febs Lett 283, no. 1 (May 20, 1991): 122–26. https://doi.org/10.1016/0014-5793(91)80568-n.Full Text Link to Item
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Fremeau, R. T., G. E. Duncan, M. G. Fornaretto, A. Dearry, J. A. Gingrich, G. R. Breese, and M. G. Caron. “Localization of D1 dopamine receptor mRNA in brain supports a role in cognitive, affective, and neuroendocrine aspects of dopaminergic neurotransmission.” Proc Natl Acad Sci U S A 88, no. 9 (May 1, 1991): 3772–76. https://doi.org/10.1073/pnas.88.9.3772.Full Text Link to Item
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Hausdorff, W. P., P. T. Campbell, J. Ostrowski, S. S. Yu, M. G. Caron, and R. J. Lefkowitz. “A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation.” Proc Natl Acad Sci U S A 88, no. 8 (April 15, 1991): 2979–83. https://doi.org/10.1073/pnas.88.8.2979.Full Text Link to Item
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Lomasney, J. W., S. Cotecchia, W. Lorenz, W. Y. Leung, D. A. Schwinn, T. L. Yang-Feng, M. Brownstein, R. J. Lefkowitz, and M. G. Caron. “Molecular cloning and expression of the cDNA for the alpha 1A-adrenergic receptor. The gene for which is located on human chromosome 5.” J Biol Chem 266, no. 10 (April 5, 1991): 6365–69.Link to Item
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Kurose, H., J. W. Regan, M. G. Caron, and R. J. Lefkowitz. “Functional interactions of recombinant alpha 2 adrenergic receptor subtypes and G proteins in reconstituted phospholipid vesicles.” Biochemistry 30, no. 13 (April 2, 1991): 3335–41. https://doi.org/10.1021/bi00227a024.Full Text Link to Item
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Liggett, S. B., M. G. Caron, R. J. Lefkowitz, and M. Hnatowich. “Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process.” J Biol Chem 266, no. 8 (March 15, 1991): 4816–21.Link to Item
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Campbell, P. T., M. Hnatowich, B. F. O’Dowd, M. G. Caron, R. J. Lefkowitz, and W. P. Hausdorff. “Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration.” Mol Pharmacol 39, no. 2 (February 1991): 192–98.Link to Item
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Raymond, J. R., F. J. Albers, J. P. Middleton, R. J. Lefkowitz, M. G. Caron, L. M. Obeid, and V. W. Dennis. “5-HT1A and histamine H1 receptors in HeLa cells stimulate phosphoinositide hydrolysis and phosphate uptake via distinct G protein pools.” J Biol Chem 266, no. 1 (January 5, 1991): 372–79.Link to Item
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Bates, M. D., S. E. Senogles, J. R. Bunzow, S. B. Liggett, O. Civelli, and M. G. Caron. “Regulation of responsiveness at D2 dopamine receptors by receptor desensitization and adenylyl cyclase sensitization.” Mol Pharmacol 39, no. 1 (January 1991): 55–63.Link to Item
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Blakely, R. D., H. E. Berson, R. T. F. Jr, M. G. Caron, M. M. Peek, H. K. Prince, and C. C. Bradley. “Cloning and expression of a functional serotonin transporter from rat brain.” Nature 354, no. 6348 (1991): 66–70.
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Caron, M. G., and V. Pliska. “Receptor research: the past, the present and the outlook.” J Recept Res 11, no. 1–4 (1991): 717–19. https://doi.org/10.3109/10799899109066438.Full Text Link to Item
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Collins, S., M. G. Caron, and R. J. Lefkowitz. “Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression.” Annu Rev Physiol 53 (1991): 497–508. https://doi.org/10.1146/annurev.ph.53.030191.002433.Full Text Link to Item
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Collins, S., M. J. Lohse, B. O’Dowd, M. G. Caron, and R. J. Lefkowitz. “Structure and regulation of G protein-coupled receptors: the beta 2-adrenergic receptor as a model.” Vitam Horm 46 (1991): 1–39. https://doi.org/10.1016/s0083-6729(08)60681-0.Full Text Link to Item
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Dearry, A., P. Falardeau, C. Shores, and M. G. Caron. “D2 dopamine receptors in the human retina: Cloning of cDNA and localization of mRNA.” Cellular and Molecular Neurobiology 11, no. 5 (1991): 437–53.
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Dohlman, H. G., J. Thorner, M. G. Caron, and R. J. Lefkowitz. “Model systems for the study of seven-transmembrane-segment receptors.” Annu Rev Biochem 60 (1991): 653–88. https://doi.org/10.1146/annurev.bi.60.070191.003253.Full Text Link to Item
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Fargin, A., K. Yamamoto, S. Cotecchia, P. K. Goldsmith, A. M. Spiegel, E. G. Lapetina, M. G. Caron, and R. J. Lefkowitz. “Dual coupling of the cloned 5-HT1A receptor to both adenylyl cyclase and phospholipase C is mediated via the same Gi protein.” Cell Signal 3, no. 6 (1991): 547–57. https://doi.org/10.1016/0898-6568(91)90031-o.Full Text Link to Item
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Gingrich, J. A., A. Dearry, P. Falardeau, R. T. Fremeau, M. D. Bates, and M. G. Caron. “Molecular characterization of G-protein coupled receptors: isolation and cloning of a D1 dopamine receptor.” J Recept Res 11, no. 1–4 (1991): 521–34. https://doi.org/10.3109/10799899109066425.Full Text Link to Item
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Liggett, S. B., J. Ostrowski, L. C. Chesnut, M. G. Caron, and R. J. Lefkowitz. “Role of the beta-adrenergic receptor kinase in desensitization of the alpha 2-adrenergic receptor.” Trans Assoc Am Physicians 104 (1991): 40–47.Link to Item
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Roth, N. S., R. J. Lefkowitz, and M. G. Caron. “Structure and function of the adrenergic receptor family.” Adv Exp Med Biol 308 (1991): 223–38. https://doi.org/10.1007/978-1-4684-6015-5_20.Full Text Link to Item
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Schwinn, D. A., S. O. Page, J. P. Middleton, W. Lorenz, S. B. Liggett, K. Yamamoto, E. G. Lapetina, M. G. Caron, R. J. Lefkowitz, and S. Cotecchia. “The α1C-adrenergic receptor: Characterization of signal transduction pathways and mammalian tissue heterogeneity.” Molecular Pharmacology 40, no. 5 (1991): 619–26.
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Schwinn, D. A., S. O. Page, J. P. Middleton, W. Lorenz, S. B. Liggett, K. Yamamoto, E. G. Lapetina, M. G. Caron, R. J. Lefkowitz, and S. Cotecchia. “The α(1C)-adrenergic receptor: Characterization of signal transduction pathways and mammalian tissue heterogeneity.” Molecular Pharmacology 40, no. 5 (January 1, 1991): 619–26.
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Hausdorff, W. P., M. G. Caron, and R. J. Lefkowitz. “Erratum: Turning off the signal: Desensitization of β-adrenergic receptor function (FASEB J. (1990) 4, 2881-2889).” Faseb Journal 4, no. 12 (December 4, 1990): 3049.
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Collins, S., J. Altschmied, O. Herbsman, M. G. Caron, P. L. Mellon, and R. J. Lefkowitz. “A cAMP response element in the beta 2-adrenergic receptor gene confers transcriptional autoregulation by cAMP.” J Biol Chem 265, no. 31 (November 5, 1990): 19330–35.Link to Item
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Lorenz, W., J. W. Lomasney, S. Collins, J. W. Regan, M. G. Caron, and R. J. Lefkowitz. “Expression of three alpha 2-adrenergic receptor subtypes in rat tissues: implications for alpha 2 receptor classification.” Mol Pharmacol 38, no. 5 (November 1990): 599–603.Link to Item
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King, K., H. G. Dohlman, J. Thorner, M. G. Caron, and R. J. Lefkowitz. “Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit.” Science 250, no. 4977 (October 5, 1990): 121–23. https://doi.org/10.1126/science.2171146.Full Text Link to Item
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Dearry, A., J. A. Gingrich, P. Falardeau, R. T. Fremeau, M. D. Bates, and M. G. Caron. “Molecular cloning and expression of the gene for a human D1 dopamine receptor.” Nature 347, no. 6288 (September 6, 1990): 72–76. https://doi.org/10.1038/347072a0.Full Text Link to Item
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Collins, S., M. Bouvier, M. J. Lohse, J. L. Benovic, M. G. Caron, and R. J. Lefkowitz. “Mechanisms involved in adrenergic receptor desensitization.” Biochem Soc Trans 18, no. 4 (August 1990): 541–44. https://doi.org/10.1042/bst0180541.Full Text Link to Item
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Hausdorff, W. P., M. G. Caron, and R. J. Lefkowitz. “Turning off the signal: desensitization of beta-adrenergic receptor function.” Faseb J 4, no. 11 (August 1990): 2881–89.Link to Item
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Caron, M. G. “Structure/function and new members of the catecholamine receptor family.” European Journal of Pharmacology 183, no. 1 (July 1, 1990): 104. https://doi.org/10.1016/0014-2999(90)91364-H.Full Text
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Lomasney, J. W., W. Lorenz, L. F. Allen, K. King, J. W. Regan, T. L. Yang-Feng, M. G. Caron, and R. J. Lefkowitz. “Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.” Proc Natl Acad Sci U S A 87, no. 13 (July 1990): 5094–98. https://doi.org/10.1073/pnas.87.13.5094.Full Text Open Access Copy Link to Item
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Valiquette, M., H. Bonin, M. Hnatowich, M. G. Caron, R. J. Lefkowitz, and M. Bouvier. “Involvement of tyrosine residues located in the carboxyl tail of the human beta 2-adrenergic receptor in agonist-induced down-regulation of the receptor.” Proc Natl Acad Sci U S A 87, no. 13 (July 1990): 5089–93. https://doi.org/10.1073/pnas.87.13.5089.Full Text Open Access Copy Link to Item
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Lohse, M. J., J. L. Benovic, J. Codina, M. G. Caron, and R. J. Lefkowitz. “beta-Arrestin: a protein that regulates beta-adrenergic receptor function.” Science 248, no. 4962 (June 22, 1990): 1547–50. https://doi.org/10.1126/science.2163110.Full Text Link to Item
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Andersen, P. H., J. A. Gingrich, M. D. Bates, A. Dearry, P. Falardeau, S. E. Senogles, and M. G. Caron. “Dopamine receptor subtypes: beyond the D1/D2 classification.” Trends Pharmacol Sci 11, no. 6 (June 1990): 231–36. https://doi.org/10.1016/0165-6147(90)90249-8.Full Text Link to Item
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Bates, M. D., J. A. Gingrich, J. R. Bunzow, P. Falardeau, A. Dearry, S. E. Senogles, O. Civelli, and M. G. Caron. “Molecular characterization of dopamine receptors.” Am J Hypertens 3, no. 6 Pt 2 (June 1990): 29S-33S. https://doi.org/10.1093/ajh/3.6.29s.Full Text Link to Item
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Schwinn, D. A., J. W. Lomasney, W. Lorenz, P. J. Szklut, R. T. Fremeau, T. L. Yang-Feng, M. G. Caron, R. J. Lefkowitz, and S. Cotecchia. “Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype.” J Biol Chem 265, no. 14 (May 15, 1990): 8183–89.Link to Item
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Lefkowitz, R. J., W. P. Hausdorff, and M. G. Caron. “Role of phosphorylation in desensitization of the beta-adrenoceptor.” Trends Pharmacol Sci 11, no. 5 (May 1990): 190–94. https://doi.org/10.1016/0165-6147(90)90113-m.Full Text Link to Item
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Seuwen, K., I. Magnaldo, B. K. Kobilka, M. G. Caron, J. W. Regan, R. J. Lefkowitz, and J. Pouysségur. “Alpha 2-adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human alpha 2-adrenergic receptor gene.” Cell Regul 1, no. 6 (May 1990): 445–51. https://doi.org/10.1091/mbc.1.6.445.Full Text Link to Item
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Seuwen, K., I. Magnaldo, B. K. Kobilka, M. G. Caron, J. W. Regan, R. J. Lefkowitz, and J. Pouysségur. “α2-Adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human α2-adrenergic receptor gene.” Molecular Biology of the Cell 1, no. 6 (May 1, 1990): 445–51.
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Cotecchia, S., S. Exum, M. G. Caron, and R. J. Lefkowitz. “Regions of the alpha 1-adrenergic receptor involved in coupling to phosphatidylinositol hydrolysis and enhanced sensitivity of biological function.” Proc Natl Acad Sci U S A 87, no. 8 (April 1990): 2896–2900. https://doi.org/10.1073/pnas.87.8.2896.Full Text Open Access Copy Link to Item
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Senogles, S. E., A. M. Spiegel, E. Padrell, R. Iyengar, and M. G. Caron. “Specificity of receptor-G protein interactions. Discrimination of Gi subtypes by the D2 dopamine receptor in a reconstituted system.” J Biol Chem 265, no. 8 (March 15, 1990): 4507–14.Link to Item
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Dohlman, H. G., M. G. Caron, A. DeBlasi, T. Frielle, and R. J. Lefkowitz. “Role of extracellular disulfide-bonded cysteines in the ligand binding function of the beta 2-adrenergic receptor.” Biochemistry 29, no. 9 (March 6, 1990): 2335–42. https://doi.org/10.1021/bi00461a018.Full Text Link to Item
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Lohse, M. J., J. L. Benovic, M. G. Caron, and R. J. Lefkowitz. “Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.” J Biol Chem 265, no. 6 (February 25, 1990): 3202–11.Link to Item
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Raymond, J. R., M. Hnatowich, R. J. Lefkowitz, and M. G. Caron. “Adrenergic receptors. Models for regulation of signal transduction processes.” Hypertension 15, no. 2 (February 1990): 119–31. https://doi.org/10.1161/01.hyp.15.2.119.Full Text Open Access Copy Link to Item
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Yang-Feng, T. L., F. Y. Xue, W. W. Zhong, S. Cotecchia, T. Frielle, M. G. Caron, R. J. Lefkowitz, and U. Francke. “Chromosomal organization of adrenergic receptor genes.” Proc Natl Acad Sci U S A 87, no. 4 (February 1990): 1516–20. https://doi.org/10.1073/pnas.87.4.1516.Full Text Open Access Copy Link to Item
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Hausdorff, W. P., M. Hnatowich, B. F. O’Dowd, M. G. Caron, and R. J. Lefkowitz. “A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs.” J Biol Chem 265, no. 3 (January 25, 1990): 1388–93.Link to Item
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Cotecchia, S., B. K. Kobilka, K. W. Daniel, R. D. Nolan, E. Y. Lapetina, M. G. Caron, R. J. Lefkowitz, and J. W. Regan. “Multiple second messenger pathways of alpha-adrenergic receptor subtypes expressed in eukaryotic cells.” J Biol Chem 265, no. 1 (January 5, 1990): 63–69.Link to Item
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Andersen, P. H., J. A. Gingrich, M. D. Bates, A. Dearry, P. Falardeau, S. E. Senogles, and M. G. Caron. “Dopamine receptor subtypes: Beyond the D1/D2 classification.” Trends in Pharmacological Sciences 11, no. 6 (1990): 231–36.
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Benovic, J. L., J. J. Onorato, M. G. Caron, and R. J. Lefkowitz. “Regulation of G protein-coupled receptors by agonist-dependent phosphorylation.” Soc Gen Physiol Ser 45 (1990): 87–103.Link to Item
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Benovic, J. L., J. J. Onorato, M. G. Caron, and R. J. Lefkowitz. “Regulation of G protein-coupled receptors by agonist-dependent phosphorylation.” Society of General Physiologists Series 45 (1990): 87–103.
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Benovic, J. L., J. Onorato, M. J. Lohse, H. G. Dohlman, C. Staniszewski, M. G. Caron, and R. J. Lefkowitz. “Synthetic peptides of the hamster beta 2-adrenoceptor as substrates and inhibitors of the beta-adrenoceptor kinase.” Br J Clin Pharmacol 30 Suppl 1 (1990): 3S-12S. https://doi.org/10.1111/j.1365-2125.1990.tb05462.x.Full Text Link to Item
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Hausdorff, W. P., M. J. Lohse, M. Bouvier, S. B. Liggett, M. G. Caron, and R. J. Lefkowitz. “Two kinases mediate agonist-dependent phosphorylation and desensitization of the beta 2-adrenergic receptor.” Symp Soc Exp Biol 44 (1990): 225–40.Link to Item
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Lefkowitz, R. J., and M. G. Caron. “Adrenergic receptors.” Harvey Lect 86 (1990): 33–45.Link to Item
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Lefkowitz, R. J., and M. G. Caron. “The adrenergic receptors.” Adv Second Messenger Phosphoprotein Res 24 (1990): 1–8.Link to Item
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Schwinn, D. A., S. Cotecchia, W. Lorenz, M. G. Caron, and R. J. Lefkowitz. “The alpha 1C-adrenergic receptor: a new member in the alpha 1-adrenergic receptor family.” Trans Assoc Am Physicians 103 (1990): 112–18.Link to Item
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Seuwen, K., I. Magnaldo, B. K. Kobilka, M. G. Caron, J. W. Regan, R. J. Lefkowitz, and J. Pouysségur. “α2-Adrenergic agonists stimulate DNA synthesis in Chinese hamster lung fibroblasts transfected with a human α2-adrenergic receptor gene.” Molecular Biology of the Cell 1, no. 6 (1990): 445–51.
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Raymond, J. R., A. Fargin, J. P. Middleton, J. M. Graff, D. M. Haupt, M. G. Caron, R. J. Lefkowitz, and V. W. Dennis. “The human 5-HT1A receptor expressed in HeLa cells stimulates sodium-dependent phosphate uptake via protein kinase C.” J Biol Chem 264, no. 36 (December 25, 1989): 21943–50.Link to Item
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Matsui, H., R. J. Lefkowitz, M. G. Caron, and J. W. Regan. “Erratum: Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet α2-adrenergic receptor (Biochemistry (1989) 28, 9, (4125-4130)).” Biochemistry 28, no. 13 (December 1, 1989): 5702.
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Liggett, S. B., M. Bouvier, B. F. O’Dowd, M. G. Caron, R. J. Lefkowitz, and A. DeBlasi. “Substitution of an extracellular cysteine in the beta 2-adrenergic receptor enhances agonist-promoted phosphorylation and receptor desensitization.” Biochem Biophys Res Commun 165, no. 1 (November 30, 1989): 257–63. https://doi.org/10.1016/0006-291x(89)91063-2.Full Text Link to Item
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Benovic, J. L., A. DeBlasi, W. C. Stone, M. G. Caron, and R. J. Lefkowitz. “Beta-adrenergic receptor kinase: primary structure delineates a multigene family.” Science 246, no. 4927 (October 13, 1989): 235–40. https://doi.org/10.1126/science.2552582.Full Text Link to Item
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Bouvier, M., S. Collins, B. F. O’Dowd, P. T. Campbell, A. de Blasi, B. K. Kobilka, C. MacGregor, G. P. Irons, M. G. Caron, and R. J. Lefkowitz. “Two distinct pathways for cAMP-mediated down-regulation of the beta 2-adrenergic receptor. Phosphorylation of the receptor and regulation of its mRNA level.” J Biol Chem 264, no. 28 (October 5, 1989): 16786–92.Link to Item
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Liggett, S. B., M. Bouvier, W. P. Hausdorff, B. O’Dowd, M. G. Caron, and R. J. Lefkowitz. “Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites.” Mol Pharmacol 36, no. 4 (October 1989): 641–46.Link to Item
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Lefkowitz, R. J., B. K. Kobilka, and M. G. Caron. “The new biology of drug receptors.” Biochem Pharmacol 38, no. 18 (September 15, 1989): 2941–48. https://doi.org/10.1016/0006-2952(89)90001-4.Full Text Link to Item
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Fargin, A., J. R. Raymond, J. W. Regan, S. Cotecchia, R. J. Lefkowitz, and M. G. Caron. “Effector coupling mechanisms of the cloned 5-HT1A receptor.” J Biol Chem 264, no. 25 (September 5, 1989): 14848–52.Link to Item
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Hausdorff, W. P., M. Bouvier, B. F. O’Dowd, G. P. Irons, M. G. Caron, and R. J. Lefkowitz. “Phosphorylation sites on two domains of the beta 2-adrenergic receptor are involved in distinct pathways of receptor desensitization.” J Biol Chem 264, no. 21 (July 25, 1989): 12657–65.Link to Item
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Collins, S., M. Bouvier, M. A. Bolanowski, M. G. Caron, and R. J. Lefkowitz. “cAMP stimulates transcription of the beta 2-adrenergic receptor gene in response to short-term agonist exposure.” Proc Natl Acad Sci U S A 86, no. 13 (July 1989): 4853–57. https://doi.org/10.1073/pnas.86.13.4853.Full Text Open Access Copy Link to Item
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Raymond, J. R., A. Fargin, M. J. Lohse, J. W. Regan, S. E. Senogles, R. J. Lefkowitz, and M. G. Caron. “Identification of the ligand-binding subunit of the human 5-hydroxytryptamine1A receptor with N-(p-azido-m-[125I] iodophenethyl)spiperone, a high affinity radioiodinated photoaffinity probe.” Mol Pharmacol 36, no. 1 (July 1989): 15–21.Link to Item
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Kwatra, M. M., J. L. Benovic, M. G. Caron, R. J. Lefkowitz, and M. M. Hosey. “Phosphorylation of chick heart muscarinic cholinergic receptors by the beta-adrenergic receptor kinase.” Biochemistry 28, no. 11 (May 30, 1989): 4543–47. https://doi.org/10.1021/bi00437a005.Full Text Link to Item
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O’Dowd, B. F., M. Hnatowich, M. G. Caron, R. J. Lefkowitz, and M. Bouvier. “Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.” J Biol Chem 264, no. 13 (May 5, 1989): 7564–69.Link to Item
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Matsui, H., R. J. Lefkowitz, M. G. Caron, and J. W. Regan. “Localization of the fourth membrane spanning domain as a ligand binding site in the human platelet alpha 2-adrenergic receptor.” Biochemistry 28, no. 9 (May 2, 1989): 4125–30. https://doi.org/10.1021/bi00435a075.Full Text Link to Item
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Frielle, T., M. G. Caron, and R. J. Lefkowitz. “Properties of the beta 1- and beta 2-adrenergic receptor subtypes revealed by molecular cloning.” Clin Chem 35, no. 5 (May 1989): 721–25.Link to Item
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Lohse, M. J., R. J. Lefkowitz, M. G. Caron, and J. L. Benovic. “Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.” Proc Natl Acad Sci U S A 86, no. 9 (May 1989): 3011–15. https://doi.org/10.1073/pnas.86.9.3011.Full Text Open Access Copy Link to Item
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Benovic, J. L., W. C. Stone, M. G. Caron, and R. J. Lefkowitz. “Inhibition of the beta-adrenergic receptor kinase by polyanions.” J Biol Chem 264, no. 12 (April 25, 1989): 6707–10.Link to Item
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Caron, M. G. “The guanine nucleotide regulatory protein-coupled receptors for nucleosides, nucleotides, amino acids and amine neurotransmitters.” Curr Opin Cell Biol 1, no. 2 (April 1989): 159–66. https://doi.org/10.1016/0955-0674(89)90081-1.Full Text Link to Item
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Collins, S., M. A. Bolanowski, M. G. Caron, and R. J. Lefkowitz. “Genetic regulation of beta-adrenergic receptors.” Annu Rev Physiol 51 (1989): 203–15. https://doi.org/10.1146/annurev.ph.51.030189.001223.Full Text Link to Item
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Frielle, T., M. G. Caron, and R. J. Lefkowitz. “The mammalian beta-adrenergic receptors.” Oxf Surv Eukaryot Genes 6 (1989): 53–66.Link to Item
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O’Dowd, B. F., R. J. Lefkowitz, and M. G. Caron. “Structure of the adrenergic and related receptors.” Annu Rev Neurosci 12 (1989): 67–83. https://doi.org/10.1146/annurev.ne.12.030189.000435.Full Text Link to Item
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Palacios, J. M., B. F. O’Dowd, S. Cotecchia, M. Hnatowich, M. G. Caron, and R. J. Lefkowitz. “Adrenergic receptor homologies in vertebrate and invertebrate species examined by DNA hybridization.” Life Sci 44, no. 26 (1989): 2057–65. https://doi.org/10.1016/0024-3205(89)90352-4.Full Text Link to Item
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Senogles, S. E., N. Amlaiky, P. Falardeau, and M. G. Caron. “Purification and characterization of the D2-dopamine receptor from bovine anterior pituitary.” J Biol Chem 263, no. 35 (December 15, 1988): 18996–2.Link to Item
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Frielle, T., K. W. Daniel, M. G. Caron, and R. J. Lefkowitz. “Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors.” Proc Natl Acad Sci U S A 85, no. 24 (December 1988): 9494–98. https://doi.org/10.1073/pnas.85.24.9494.Full Text Open Access Copy Link to Item
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O’Dowd, B. F., M. Hnatowich, J. W. Regan, W. M. Leader, M. G. Caron, and R. J. Lefkowitz. “Site-directed mutagenesis of the cytoplasmic domains of the human beta 2-adrenergic receptor. Localization of regions involved in G protein-receptor coupling.” J Biol Chem 263, no. 31 (November 5, 1988): 15985–92.Link to Item
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Cotecchia, S., D. A. Schwinn, R. R. Randall, R. J. Lefkowitz, M. G. Caron, and B. K. Kobilka. “Molecular cloning and expression of the cDNA for the hamster alpha 1-adrenergic receptor.” Proc Natl Acad Sci U S A 85, no. 19 (October 1988): 7159–63. https://doi.org/10.1073/pnas.85.19.7159.Full Text Open Access Copy Link to Item
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Fargin, A., J. R. Raymond, M. J. Lohse, B. K. Kobilka, M. G. Caron, and R. J. Lefkowitz. “The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor.” Nature 335, no. 6188 (September 22, 1988): 358–60. https://doi.org/10.1038/335358a0.Full Text Link to Item
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Regan, J. W., T. S. Kobilka, T. L. Yang-Feng, M. G. Caron, R. J. Lefkowitz, and B. K. Kobilka. “Cloning and expression of a human kidney cDNA for an alpha 2-adrenergic receptor subtype.” Proc Natl Acad Sci U S A 85, no. 17 (September 1988): 6301–5. https://doi.org/10.1073/pnas.85.17.6301.Full Text Open Access Copy Link to Item
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Collins, S., M. G. Caron, and R. J. Lefkowitz. “Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids.” J Biol Chem 263, no. 19 (July 5, 1988): 9067–70.Link to Item
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Frielle, T., B. Kobilka, R. J. Lefkowitz, and M. G. Caron. “Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes.” Trends Neurosci 11, no. 7 (July 1988): 321–24. https://doi.org/10.1016/0166-2236(88)90095-1.Full Text Link to Item
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Yang, S. D., Y. L. Fong, J. L. Benovic, D. R. Sibley, M. G. Caron, and R. J. Lefkowitz. “Dephosphorylation of the beta 2-adrenergic receptor and rhodopsin by latent phosphatase 2.” J Biol Chem 263, no. 18 (June 25, 1988): 8856–58.Link to Item
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Collins, S., V. E. Quarmby, F. S. French, R. J. Lefkowitz, and M. G. Caron. “Regulation of the beta 2-adrenergic receptor and its mRNA in the rat ventral prostate by testosterone.” Febs Lett 233, no. 1 (June 6, 1988): 173–76. https://doi.org/10.1016/0014-5793(88)81378-4.Full Text Link to Item
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Kobilka, B. K., T. S. Kobilka, K. Daniel, J. W. Regan, M. G. Caron, and R. J. Lefkowitz. “Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity.” Science 240, no. 4857 (June 3, 1988): 1310–16. https://doi.org/10.1126/science.2836950.Full Text Link to Item
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Gingrich, J. A., N. Amlaiky, S. E. Senogles, W. K. Chang, R. D. McQuade, J. G. Berger, and M. G. Caron. “Affinity chromatography of the D1 dopamine receptor from rat corpus striatum.” Biochemistry 27, no. 11 (May 31, 1988): 3907–12. https://doi.org/10.1021/bi00411a003.Full Text Link to Item
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Bouvier, M., W. P. Hausdorff, A. De Blasi, B. F. O’Dowd, B. K. Kobilka, M. G. Caron, and R. J. Lefkowitz. “Removal of phosphorylation sites from the beta 2-adrenergic receptor delays onset of agonist-promoted desensitization.” Nature 333, no. 6171 (May 26, 1988): 370–73. https://doi.org/10.1038/333370a0.Full Text Link to Item
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Lefkowitz, R. J., and M. G. Caron. “Adrenergic receptors. Models for the study of receptors coupled to guanine nucleotide regulatory proteins.” J Biol Chem 263, no. 11 (April 15, 1988): 4993–96.Link to Item
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Dohlman, H. G., M. G. Caron, C. D. Strader, N. Amlaiky, and R. J. Lefkowitz. “Identification and sequence of a binding site peptide of the beta 2-adrenergic receptor.” Biochemistry 27, no. 6 (March 22, 1988): 1813–17. https://doi.org/10.1021/bi00406a002.Full Text Link to Item
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Benovic, J. L., C. Staniszewski, F. Mayor, M. G. Caron, and R. J. Lefkowitz. “beta-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation.” J Biol Chem 263, no. 8 (March 15, 1988): 3893–97.Link to Item
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Agui, T., N. Amlaiky, M. G. Caron, and J. W. Kebabian. “Agonist-induced desensitization of the D-2 dopamine receptor in the intermediate lobe of the rat pituitary gland.” J Biochem 103, no. 3 (March 1988): 436–41. https://doi.org/10.1093/oxfordjournals.jbchem.a122288.Full Text Link to Item
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Agui, T., N. Amlaiky, M. G. Caron, and J. W. Kebabian. “Binding of [125I]-N-(p-aminophenethyl)spiroperidol to the D-2 dopamine receptor in the neurointermediate lobe of the rat pituitary gland: a thermodynamic study.” Mol Pharmacol 33, no. 2 (February 1988): 163–69.Link to Item
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Bouvier, M., M. Hnatowich, S. Collins, B. K. Kobilka, A. Deblasi, R. J. Lefkowitz, and M. G. Caron. “Expression of a human cDNA encoding the beta 2-adrenergic receptor in Chinese hamster fibroblasts (CHW): functionality and regulation of the expressed receptors.” Mol Pharmacol 33, no. 2 (February 1988): 133–39.Link to Item
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Sibley, D. R., J. L. Benovic, M. G. Caron, and R. J. Lefkowitz. “Phosphorylation of cell surface receptors: a mechanism for regulating signal transduction pathways.” Endocr Rev 9, no. 1 (February 1988): 38–56. https://doi.org/10.1210/edrv-9-1-38.Full Text Open Access Copy Link to Item
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Benovic, J. L., C. Staniszewski, F. Mayor, M. G. Caron, and R. J. Lefkowitz. “β-Adrenergic receptor kinase. Activity of partial agonists for stimulation of adenylate cyclase correlates with ability to promote receptor phosphorylation.” Journal of Biological Chemistry 263, no. 8 (January 1, 1988): 3893–97.
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Benovic, J. L., M. Bouvier, M. G. Caron, and R. J. Lefkowitz. “Regulation of adenylyl cyclase-coupled beta-adrenergic receptors.” Annu Rev Cell Biol 4 (1988): 405–28. https://doi.org/10.1146/annurev.cb.04.110188.002201.Full Text Link to Item
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Caron, M. G., B. K. Kobilka, T. Frielle, M. A. Bolanowski, J. L. Benovic, and R. J. Lefkowitz. “Cloning of the cDNA and genes for the hamster and human beta 2-adrenergic receptors.” J Recept Res 8, no. 1–4 (1988): 7–21. https://doi.org/10.3109/10799898809048975.Full Text Link to Item
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Collins, S., M. G. Caron, and R. J. Lefkowitz. “β2-Adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids.” Journal of Biological Chemistry 263, no. 19 (1988): 9067–70.
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Collins, S., M. G. Caron, and R. J. Lefkowitz. “β2-Adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids.” Journal of Biological Chemistry 263, no. 19 (January 1, 1988): 9067–70.
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Dohlman, H. G., M. G. Caron, C. D. Strader, N. Amlaiky, and R. J. Lefkowitz. “Erratum: Identification and sequence of a binding site peptide of the β2-adrenergic receptor (Biochemistry (1988) 27, 6, (1813-1817)).” Biochemistry 27, no. 22 (January 1, 1988): 8508. https://doi.org/10.1021/bi00422a034.Full Text
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Lefkowitz, R. J., B. K. Kobilka, J. L. Benovic, M. Bouvier, S. Cotecchia, W. P. Hausdorff, H. G. Dohlman, J. W. Regan, and M. G. Caron. “Molecular biology of adrenergic receptors.” Cold Spring Harb Symp Quant Biol 53 Pt 1 (1988): 507–14. https://doi.org/10.1101/sqb.1988.053.01.058.Full Text Link to Item
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Lefkowitz, R. J., and M. G. Caron. “Adrenergic receptors.” Adv Second Messenger Phosphoprotein Res 21 (1988): 1–10.Link to Item
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McQuade, R. D., R. Chipkin, N. Amlaiky, M. Caron, L. Iorio, and A. Barnett. “Characterization of the radioiodinated analogue of SCH 23390: in vitro and in vivo D-1 dopamine receptor binding studies.” Life Sci 43, no. 14 (1988): 1151–60. https://doi.org/10.1016/0024-3205(88)90474-2.Full Text Link to Item
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Senogles, S. E., N. Amlaiky, J. G. Berger, and M. G. Caron. “Biochemical properties of D1 and D2 dopamine receptors.” Adv Exp Med Biol 235 (1988): 33–41. https://doi.org/10.1007/978-1-4899-2723-1_3.Full Text Link to Item
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Strasser, R. H., J. L. Benovic, R. J. Lefkowitz, and M. G. Caron. “The beta-adrenergic receptor kinase: role in homologous desensitization in S49 lymphoma cells.” Adv Exp Med Biol 231 (1988): 503–17. https://doi.org/10.1007/978-1-4684-9042-8_43.Full Text Link to Item
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Benovic, J. L., J. W. Regan, H. Matsui, F. Mayor, S. Cotecchia, L. M. Leeb-Lundberg, M. G. Caron, and R. J. Lefkowitz. “Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.” J Biol Chem 262, no. 36 (December 25, 1987): 17251–53.Link to Item
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Benovic, J. L., H. Kühn, I. Weyand, J. Codina, M. G. Caron, and R. J. Lefkowitz. “Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).” Proc Natl Acad Sci U S A 84, no. 24 (December 1987): 8879–82. https://doi.org/10.1073/pnas.84.24.8879.Full Text Open Access Copy Link to Item
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Dohlman, H. G., M. G. Caron, and R. J. Lefkowitz. “Structure and function of the beta 2-adrenergic receptor--homology with rhodopsin.” Kidney Int Suppl 23 (December 1987): S2-13.Link to Item
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Kobilka, B. K., C. MacGregor, K. Daniel, T. S. Kobilka, M. G. Caron, and R. J. Lefkowitz. “Functional activity and regulation of human beta 2-adrenergic receptors expressed in Xenopus oocytes.” J Biol Chem 262, no. 32 (November 15, 1987): 15796–802.Link to Item
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Frielle, T., S. Collins, K. W. Daniel, M. G. Caron, R. J. Lefkowitz, and B. K. Kobilka. “Cloning of the cDNA for the human beta 1-adrenergic receptor.” Proc Natl Acad Sci U S A 84, no. 22 (November 1987): 7920–24. https://doi.org/10.1073/pnas.84.22.7920.Full Text Open Access Copy Link to Item
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Kobilka, B. K., H. Matsui, T. S. Kobilka, T. L. Yang-Feng, U. Francke, M. G. Caron, R. J. Lefkowitz, and J. W. Regan. “Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.” Science 238, no. 4827 (October 30, 1987): 650–56. https://doi.org/10.1126/science.2823383.Full Text Link to Item
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Dohlman, H. G., M. Bouvier, J. L. Benovic, M. G. Caron, and R. J. Lefkowitz. “The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis.” J Biol Chem 262, no. 29 (October 15, 1987): 14282–88.Link to Item
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Kobilka, B. K., T. Frielle, S. Collins, T. Yang-Feng, T. S. Kobilka, U. Francke, R. J. Lefkowitz, and M. G. Caron. “An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins.” Nature 329, no. 6134 (September 3, 1987): 75–79. https://doi.org/10.1038/329075a0.Full Text Link to Item
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Benovic, J. L., F. Mayor, C. Staniszewski, R. J. Lefkowitz, and M. G. Caron. “Purification and characterization of the beta-adrenergic receptor kinase.” J Biol Chem 262, no. 19 (July 5, 1987): 9026–32.Link to Item
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Kobilka, B. K., T. Frielle, H. G. Dohlman, M. A. Bolanowski, R. A. Dixon, P. Keller, M. G. Caron, and R. J. Lefkowitz. “Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.” J Biol Chem 262, no. 15 (May 25, 1987): 7321–27.Link to Item
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Dohlman, H. G., M. G. Caron, and R. J. Lefkowitz. “A family of receptors coupled to guanine nucleotide regulatory proteins.” Biochemistry 26, no. 10 (May 19, 1987): 2657–64. https://doi.org/10.1021/bi00384a001.Full Text Link to Item
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Mayor, F., J. L. Benovic, M. G. Caron, and R. J. Lefkowitz. “Somatostatin induces translocation of the beta-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells.” J Biol Chem 262, no. 14 (May 15, 1987): 6468–71.Link to Item
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Yoshimasa, T., D. R. Sibley, M. Bouvier, R. J. Lefkowitz, and M. G. Caron. “Cross-talk between cellular signalling pathways suggested by phorbol-ester-induced adenylate cyclase phosphorylation.” Nature 327, no. 6117 (May 7, 1987): 67–70. https://doi.org/10.1038/327067a0.Full Text Link to Item
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Senogles, S. E., J. L. Benovic, N. Amlaiky, C. Unson, G. Milligan, R. Vinitsky, A. M. Spiegel, and M. G. Caron. “The D2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein.” J Biol Chem 262, no. 10 (April 5, 1987): 4860–67.Link to Item
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Sibley, D. R., J. L. Benovic, M. G. Caron, and R. J. Lefkowitz. “Regulation of transmembrane signaling by receptor phosphorylation.” Cell 48, no. 6 (March 27, 1987): 913–22. https://doi.org/10.1016/0092-8674(87)90700-8.Full Text Link to Item
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Cerione, R. A., P. Gierschik, C. Staniszewski, J. L. Benovic, J. Codina, R. Somers, L. Birnbaumer, A. M. Spiegel, R. J. Lefkowitz, and M. G. Caron. “Functional differences in the beta gamma complexes of transducin and the inhibitory guanine nucleotide regulatory protein.” Biochemistry 26, no. 5 (March 10, 1987): 1485–91. https://doi.org/10.1021/bi00379a041.Full Text Link to Item
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Bouvier, M., L. M. Leeb-Lundberg, J. L. Benovic, M. G. Caron, and R. J. Lefkowitz. “Regulation of adrenergic receptor function by phosphorylation. II. Effects of agonist occupancy on phosphorylation of alpha 1- and beta 2-adrenergic receptors by protein kinase C and the cyclic AMP-dependent protein kinase.” J Biol Chem 262, no. 7 (March 5, 1987): 3106–13.Link to Item
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Leeb-Lundberg, L. M., S. Cotecchia, A. DeBlasi, M. G. Caron, and R. J. Lefkowitz. “Regulation of adrenergic receptor function by phosphorylation. I. Agonist-promoted desensitization and phosphorylation of alpha 1-adrenergic receptors coupled to inositol phospholipid metabolism in DDT1 MF-2 smooth muscle cells.” J Biol Chem 262, no. 7 (March 5, 1987): 3098–3105.Link to Item
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Amlaiky, N., J. G. Berger, W. Chang, R. J. McQuade, and M. G. Caron. “Identification of the binding subunit of the D1-dopamine receptor by photoaffinity crosslinking.” Mol Pharmacol 31, no. 2 (February 1987): 129–34.Link to Item
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Benovic, J. L., C. Staniszewski, R. A. Cerione, J. Codina, R. J. Lefkowitz, and M. G. Caron. “The mammalian beta-adrenergic receptor: structural and functional characterization of the carbohydrate moiety.” J Recept Res 7, no. 1–4 (1987): 257–81. https://doi.org/10.3109/10799898709054989.Full Text Link to Item
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Kobilka, B. K., C. MacGregor, K. Daniel, T. S. Kobilka, M. G. Caron, and R. J. Lefkowitz. “Functional activity and regulation of human β2-adrenergic receptors expressed in Xenopus oocytes.” Journal of Biological Chemistry 262, no. 32 (January 1, 1987).
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Kobilka, B. K., R. A. Dixon, T. Frielle, H. G. Dohlman, M. A. Bolanowski, I. S. Sigal, T. L. Yang-Feng, U. Francke, M. G. Caron, and R. J. Lefkowitz. “cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.” Proc Natl Acad Sci U S A 84, no. 1 (January 1987): 46–50. https://doi.org/10.1073/pnas.84.1.46.Full Text Open Access Copy Link to Item
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Lefkowitz, R. J., and M. G. Caron. “Molecular and regulatory properties of adrenergic receptors.” Recent Prog Horm Res 43 (1987): 469–97. https://doi.org/10.1016/b978-0-12-571143-2.50018-6.Full Text Link to Item
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Senogles, S. E., J. L. Benovic, N. Amlaiky, C. Unson, G. Milligan, R. Vinitsky, A. M. Spiegel, and M. G. Caron. “The D 2-dopamine receptor of anterior pituitary is functionally associated with a pertussis toxin-sensitive guanine nucleotide binding protein.” Journal of Biological Chemistry 262, no. 10 (1987): 4860–67.
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Sibley, D. R., J. L. Benovic, M. G. Caron, and R. J. Lefkowitz. “Molecular mechanisms of beta-adrenergic receptor desensitization.” Adv Exp Med Biol 221 (1987): 253–73. https://doi.org/10.1007/978-1-4684-7618-7_19.Full Text Link to Item
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Bouvier, C., M. Potier, G. Beauregard, J. Lafond, N. Amlaiky, M. G. Caron, and R. Collu. “Solubilization and characterization of D2-dopamine receptors in an estrone-induced, prolactin-secreting rat pituitary adenoma.” J Neurochem 47, no. 5 (November 1986): 1653–60. https://doi.org/10.1111/j.1471-4159.1986.tb00809.x.Full Text Link to Item
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Lefkowitz, R. J., and M. G. Caron. “Ciba-Geigy award for outstanding research. Regulation of adrenergic receptor function by phosphorylation.” J Mol Cell Cardiol 18, no. 9 (September 1986): 885–95. https://doi.org/10.1016/s0022-2828(86)80003-7.Full Text Link to Item
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Strasser, R. H., J. L. Benovic, M. G. Caron, and R. J. Lefkowitz. “Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors.” Proc Natl Acad Sci U S A 83, no. 17 (September 1986): 6362–66. https://doi.org/10.1073/pnas.83.17.6362.Full Text Open Access Copy Link to Item
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Cerione, R. A., C. Staniszewski, P. Gierschik, J. Codina, R. L. Somers, L. Birnbaumer, A. M. Spiegel, M. G. Caron, and R. J. Lefkowitz. “Mechanism of guanine nucleotide regulatory protein-mediated inhibition of adenylate cyclase. Studies with isolated subunits of transducin in a reconstituted system.” J Biol Chem 261, no. 20 (July 15, 1986): 9514–20.Link to Item
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Amlaiky, N., and M. G. Caron. “Identification of the D2-dopamine receptor binding subunit in several mammalian tissues and species by photoaffinity labeling.” J Neurochem 47, no. 1 (July 1986): 196–204. https://doi.org/10.1111/j.1471-4159.1986.tb02850.x.Full Text Link to Item
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Benovic, J. L., F. Mayor, R. L. Somers, M. G. Caron, and R. J. Lefkowitz. “Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase.” Nature 321, no. 6073 (June 26, 1986): 869–72. https://doi.org/10.1038/321869a0.Full Text Link to Item
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Lomasney, J. W., L. M. Leeb-Lundberg, S. Cotecchia, J. W. Regan, J. F. DeBernardis, M. G. Caron, and R. J. Lefkowitz. “Mammalian alpha 1-adrenergic receptor. Purification and characterization of the native receptor ligand binding subunit.” J Biol Chem 261, no. 17 (June 15, 1986): 7710–16.Link to Item
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Benovic, J. L., R. H. Strasser, M. G. Caron, and R. J. Lefkowitz. “Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.” Proc Natl Acad Sci U S A 83, no. 9 (May 1986): 2797–2801. https://doi.org/10.1073/pnas.83.9.2797.Full Text Open Access Copy Link to Item
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Dixon, R. A., B. K. Kobilka, D. J. Strader, J. L. Benovic, H. G. Dohlman, T. Frielle, M. A. Bolanowski, et al. “Cloning of the gene and cDNA for mammalian beta-adrenergic receptor and homology with rhodopsin.” Nature 321, no. 6065 (May 1, 1986): 75–79. https://doi.org/10.1038/321075a0.Full Text Link to Item
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Dickinson, K. E., L. M. Leeb-Lundberg, R. H. Strasser, M. G. Caron, and R. J. Lefkowitz. “Identification of the subunit structure of rat pineal adrenergic receptors by photoaffinity labeling.” J Neurochem 46, no. 4 (April 1986): 1153–60. https://doi.org/10.1111/j.1471-4159.1986.tb00630.x.Full Text Link to Item
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Regan, J. W., H. Nakata, R. M. DeMarinis, M. G. Caron, and R. J. Lefkowitz. “Purification and characterization of the human platelet alpha 2-adrenergic receptor.” J Biol Chem 261, no. 8 (March 15, 1986): 3894–3900.Link to Item
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Senogles, S. E., N. Amlaiky, A. L. Johnson, and M. G. Caron. “Affinity chromatography of the anterior pituitary D2-dopamine receptor.” Biochemistry 25, no. 4 (February 25, 1986): 749–53. https://doi.org/10.1021/bi00352a002.Full Text Link to Item
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Lefkowitz, R. J., J. L. Benovic, B. Kobilka, and M. G. Caron. “β-Adrenergic receptors and rhodopsin: shedding new light on an old subject.” Trends in Pharmacological Sciences 7, no. C (January 1, 1986): 444–48. https://doi.org/10.1016/0165-6147(86)90417-7.Full Text
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Lefkowitz, R. J., and M. G. Caron. “Regulation of adrenergic receptor function by phosphorylation.” Curr Top Cell Regul 28 (1986): 209–31. https://doi.org/10.1016/b978-0-12-152828-7.50007-x.Full Text Link to Item
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Cotecchia, S., L. M. Leeb-Lundberg, P. O. Hagen, R. J. Lefkowitz, and M. G. Caron. “Phorbol ester effects on alpha 1-adrenoceptor binding and phosphatidylinositol metabolism in cultured vascular smooth muscle cells.” Life Sci 37, no. 25 (December 23, 1985): 2389–98. https://doi.org/10.1016/0024-3205(85)90106-7.Full Text Link to Item
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Cerione, R. A., C. Staniszewski, M. G. Caron, R. J. Lefkowitz, J. Codina, and L. Birnbaumer. “A role for Ni in the hormonal stimulation of adenylate cyclase.” Nature 318, no. 6043 (November 21, 1985): 293–95. https://doi.org/10.1038/318293a0.Full Text Link to Item
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Leeb-Lundberg, L. M., S. Cotecchia, J. W. Lomasney, J. F. DeBernardis, R. J. Lefkowitz, and M. G. Caron. “Phorbol esters promote alpha 1-adrenergic receptor phosphorylation and receptor uncoupling from inositol phospholipid metabolism.” Proc Natl Acad Sci U S A 82, no. 17 (September 1985): 5651–55. https://doi.org/10.1073/pnas.82.17.5651.Full Text Open Access Copy Link to Item
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Lefkowitz, R. J., and M. G. Caron. “Adrenergic receptors: molecular mechanisms of clinically relevant regulation.” Clin Res 33, no. 3 (September 1985): 395–406.Link to Item
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Strasser, R. H., R. A. Cerione, J. Codina, M. G. Caron, and R. J. Lefkowitz. “Homologous desensitization of the beta-adrenergic receptor. Functional integrity of the desensitized receptor from mammalian lung.” Mol Pharmacol 28, no. 3 (September 1985): 237–45.Link to Item
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Cerione, R. A., J. Codina, B. F. Kilpatrick, C. Staniszewski, P. Gierschik, R. L. Somers, A. M. Spiegel, L. Birnbaumer, M. G. Caron, and R. J. Lefkowitz. “Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems.” Biochemistry 24, no. 17 (August 13, 1985): 4499–4503. https://doi.org/10.1021/bi00338a002.Full Text Link to Item
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Benovic, J. L., L. J. Pike, R. A. Cerione, C. Staniszewski, T. Yoshimasa, J. Codina, M. G. Caron, and R. J. Lefkowitz. “Phosphorylation of the mammalian beta-adrenergic receptor by cyclic AMP-dependent protein kinase. Regulation of the rate of receptor phosphorylation and dephosphorylation by agonist occupancy and effects on coupling of the receptor to the stimulatory guanine nucleotide regulatory protein.” J Biol Chem 260, no. 11 (June 10, 1985): 7094–7101.Link to Item
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Dickinson, K. E., S. L. Heald, P. W. Jeffs, R. J. Lefkowitz, and M. G. Caron. “Covalent labeling of the beta-adrenergic ligand-binding site with para-(bromoacetamidyl)benzylcarazolol. A highly potent beta-adrenergic affinity label.” Mol Pharmacol 27, no. 5 (May 1985): 499–506.Link to Item
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Sibley, D. R., R. H. Strasser, M. G. Caron, and R. J. Lefkowitz. “Homologous desensitization of adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.” J Biol Chem 260, no. 7 (April 10, 1985): 3883–86.Link to Item
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Amlaiky, N., and M. G. Caron. “Photoaffinity labeling of the D2-dopamine receptor using a novel high affinity radioiodinated probe.” J Biol Chem 260, no. 4 (February 25, 1985): 1983–86.Link to Item
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Cerione, R. A., C. Staniszewski, J. L. Benovic, R. J. Lefkowitz, M. G. Caron, P. Gierschik, R. Somers, A. M. Spiegel, J. Codina, and L. Birnbaumer. “Specificity of the functional interactions of the beta-adrenergic receptor and rhodopsin with guanine nucleotide regulatory proteins reconstituted in phospholipid vesicles.” J Biol Chem 260, no. 3 (February 10, 1985): 1493–1500.Link to Item
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Amlaiky, N., and M. G. Caron. “Identification of the D2-dopamine receptor binding subunit in mammalian tissues.” Federation Proceedings 44, no. 5 (January 1, 1985).
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Birnbaumer, L., J. Codina, R. Mattera, R. A. Cerione, J. D. Hildebrandt, T. Sunyer, F. J. Rojas, M. G. Caron, R. J. Lefkowitz, and R. Iyengar. “Regulation of hormone receptors and adenylyl cyclases by guanine nucleotide binding N proteins.” Recent Prog Horm Res 41 (1985): 41–99. https://doi.org/10.1016/b978-0-12-571141-8.50006-8.Full Text Link to Item
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Caron, M. G., R. A. Cerione, J. L. Benovic, B. Strulovici, C. Staniszewski, R. J. Lefkowitz, J. Codina-Salada, and L. Birnbaumer. “Biochemical characterization of the adrenergic receptors: affinity labeling, purification, and reconstitution studies.” Adv Cyclic Nucleotide Protein Phosphorylation Res 19 (1985): 1–12.Link to Item
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Lefkowitz, R. J., R. A. Cerione, J. Codina, L. Birnbaumer, and M. G. Caron. “Reconstitution of the beta-adrenergic receptor.” J Membr Biol 87, no. 1 (1985): 1–12. https://doi.org/10.1007/BF01870694.Full Text Link to Item
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Sibley, D. R., R. H. Strasser, M. G. Caron, and R. J. Lefkowitz. “Homologous desensitization of adenylate cyclase is associated with phosphorylation of the β-adrenergic receptor.” Federation Proceedings 44, no. 5 (January 1, 1985).
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Nambi, P., D. R. Sibley, M. G. Caron, and R. J. Lefkowitz. “Photoaffinity labeling of beta-adrenergic receptors in mammalian tissues.” Biochem Pharmacol 33, no. 23 (December 1, 1984): 3813–22. https://doi.org/10.1016/0006-2952(84)90045-5.Full Text Link to Item
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Amlaiky, N., B. F. Kilpatrick, and M. G. Caron. “A novel radioiodinated high affinity ligand for the D2-dopamine receptor. Characterization of its binding in bovine anterior pituitary membranes.” Febs Lett 176, no. 2 (October 29, 1984): 436–40. https://doi.org/10.1016/0014-5793(84)81213-2.Full Text Link to Item
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Benovic, J. L., R. G. Shorr, M. G. Caron, and R. J. Lefkowitz. “The mammalian beta 2-adrenergic receptor: purification and characterization.” Biochemistry 23, no. 20 (September 25, 1984): 4510–18. https://doi.org/10.1021/bi00315a002.Full Text Link to Item
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Cerione, R. A., J. Codina, J. L. Benovic, R. J. Lefkowitz, L. Birnbaumer, and M. G. Caron. “The mammalian beta 2-adrenergic receptor: reconstitution of functional interactions between pure receptor and pure stimulatory nucleotide binding protein of the adenylate cyclase system.” Biochemistry 23, no. 20 (September 25, 1984): 4519–25. https://doi.org/10.1021/bi00315a003.Full Text Link to Item
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Caron, M. G., L. M. Leeb-Lundberg, C. D. Strader, K. E. Dickinson, V. M. Pickel, T. Joh, and R. J. Lefkowitz. “Molecular biology of adrenergic receptors in the rat and frog central nervous system.” Hypertension 6, no. 5 Pt 2 (September 1984): II22–27. https://doi.org/10.1161/01.hyp.6.5_pt_2.ii22.Full Text Link to Item
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Dickinson, K. E., L. M. Leeb-Lundberg, S. L. Heald, J. E. Wikberg, J. F. DeBernardis, M. G. Caron, and R. J. Lefkowitz. “Photoaffinity cross-linking of a radioiodinated probe, 125I-A55453, into alpha 1-adrenergic receptors.” Mol Pharmacol 26, no. 2 (September 1984): 187–95.Link to Item
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Cerione, R. A., D. R. Sibley, J. Codina, J. L. Benovic, J. Winslow, E. J. Neer, L. Birnbaumer, M. G. Caron, and R. J. Lefkowitz. “Reconstitution of a hormone-sensitive adenylate cyclase system. The pure beta-adrenergic receptor and guanine nucleotide regulatory protein confer hormone responsiveness on the resolved catalytic unit.” J Biol Chem 259, no. 16 (August 25, 1984): 9979–82.Link to Item
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Strulovici, B., R. A. Cerione, B. F. Kilpatrick, M. G. Caron, and R. J. Lefkowitz. “Direct demonstration of impaired functionality of a purified desensitized beta-adrenergic receptor in a reconstituted system.” Science 225, no. 4664 (August 24, 1984): 837–40. https://doi.org/10.1126/science.6089331.Full Text Link to Item
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Sibley, D. R., J. R. Peters, P. Nambi, M. G. Caron, and R. J. Lefkowitz. “Desensitization of turkey erythrocyte adenylate cyclase. Beta-adrenergic receptor phosphorylation is correlated with attenuation of adenylate cyclase activity.” J Biol Chem 259, no. 15 (August 10, 1984): 9742–49.Link to Item
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Stiles, G. L., J. L. Benovic, M. G. Caron, and R. J. Lefkowitz. “Mammalian beta-adrenergic receptors. Distinct glycoprotein populations containing high mannose or complex type carbohydrate chains.” J Biol Chem 259, no. 13 (July 10, 1984): 8655–63.Link to Item
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DeMarinis, R. M., A. J. Krog, D. H. Shah, J. Lafferty, K. G. Holden, J. P. Hieble, W. D. Matthews, J. W. Regan, R. J. Lefkowitz, and M. G. Caron. “Development of an affinity ligand for purification of alpha 2-adrenoceptors from human platelet membranes.” J Med Chem 27, no. 7 (July 1984): 918–21. https://doi.org/10.1021/jm00373a018.Full Text Link to Item
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McDonald, W. M., D. R. Sibley, B. F. Kilpatrick, and M. G. Caron. “Dopaminergic inhibition of adenylate cyclase correlates with high affinity agonist binding to anterior pituitary D2 dopamine receptors.” Mol Cell Endocrinol 36, no. 3 (July 1984): 201–9. https://doi.org/10.1016/0303-7207(84)90037-6.Full Text Link to Item
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Regan, J. W., R. M. DeMarinis, M. G. Caron, and R. J. Lefkowitz. “Identification of the subunit-binding site of alpha 2-adrenergic receptors using [3H]phenoxybenzamine.” J Biol Chem 259, no. 12 (June 25, 1984): 7864–69.Link to Item
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Kilpatrick, B. F., and M. G. Caron. “Dopamine receptor of the porcine anterior pituitary gland. Solubilization and characterization.” Biochem Pharmacol 33, no. 12 (June 15, 1984): 1981–88. https://doi.org/10.1016/0006-2952(84)90559-8.Full Text Link to Item
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Lefkowitz, R. J., M. G. Caron, and G. L. Stiles. “Mechanisms of membrane-receptor regulation. Biochemical, physiological, and clinical insights derived from studies of the adrenergic receptors.” N Engl J Med 310, no. 24 (June 14, 1984): 1570–79. https://doi.org/10.1056/NEJM198406143102406.Full Text Open Access Copy Link to Item
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Heinsimer, J. A., A. O. Davies, R. W. Downs, M. A. Levine, A. M. Spiegel, M. K. Drezner, A. De Lean, K. A. Wreggett, M. G. Caron, and R. J. Lefkowitz. “Impaired formation of beta-adrenergic receptor-nucleotide regulatory protein complexes in pseudohypoparathyroidism.” J Clin Invest 73, no. 5 (May 1984): 1335–43. https://doi.org/10.1172/JCI111336.Full Text Open Access Copy Link to Item
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Stiles, G. L., M. G. Caron, and R. J. Lefkowitz. “Beta-adrenergic receptors: biochemical mechanisms of physiological regulation.” Physiol Rev 64, no. 2 (April 1984): 661–743. https://doi.org/10.1152/physrev.1984.64.2.661.Full Text Link to Item
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Sibley, D. R., J. R. Peters, P. Nambi, M. G. Caron, and R. J. Lefkowitz. “Photoaffinity labeling of turkey erythrocyte beta-adrenergic receptors: degradation of the Mr = 49,000 protein explains apparent heterogeneity.” Biochem Biophys Res Commun 119, no. 2 (March 15, 1984): 458–64. https://doi.org/10.1016/s0006-291x(84)80271-5.Full Text Link to Item
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Leeb-Lundberg, L. M., K. E. Dickinson, S. L. Heald, J. E. Wikberg, P. O. Hagen, J. F. DeBernardis, M. Winn, D. L. Arendsen, R. J. Lefkowitz, and M. G. Caron. “Photoaffinity labeling of mammalian alpha 1-adrenergic receptors. Identification of the ligand binding subunit with a high affinity radioiodinated probe.” J Biol Chem 259, no. 4 (February 25, 1984): 2579–87.Link to Item
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Williams, R. S., M. G. Caron, and K. Daniel. “Skeletal muscle beta-adrenergic receptors: variations due to fiber type and training.” Am J Physiol 246, no. 2 Pt 1 (February 1984): E160–67. https://doi.org/10.1152/ajpendo.1984.246.2.E160.Full Text Link to Item
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Caron, M. G., L. M. F. Leeb-Lundberg, C. D. Strader, K. E. Dickinson, V. M. Pickel, T. Joh, and R. J. Lefkowitz. “Molecular biology of adrenergic receptors in the rat and frog central nervous system.” Hypertension 6, no. 5 II (1984): II-22-II–27.
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Caron, M. G., R. A. Cerione, and J. Codina. “Reconstitution of pure components of a hormone responsive adenylate cyclase system: Interactions of the β-adrenergic receptor and the stimulatory nucleotide binding protein (N(s)).” Federation Proceedings 43, no. 6 (January 1, 1984).
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DeMarinis, R. M., A. J. Krog, D. H. Shah, J. Lafferty, K. G. Holden, J. P. Hieble, W. D. Matthews, J. W. Began, R. J. Lefkowitz, and M. G. Caron. “Erratum: Development of an affinity ligand for purification of α2-adrenoceptors from human platelet membranes (Journal of Medicinal Chemistry (1984) 27, (918)).” Journal of Medicinal Chemistry 27, no. 12 (January 1, 1984): 1753. https://doi.org/10.1021/jm00378a603.Full Text
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Lefkowitz, R. J., J. M. Stadel, R. A. Cerione, B. Strulovici, and M. G. Caron. “Structure and function of beta-adrenergic receptors: regulation at the molecular level.” Adv Cyclic Nucleotide Protein Phosphorylation Res 17 (1984): 19–28.Link to Item
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Pike, L. J., J. L. Benovic, M. G. Caron, and R. J. Lefkowitz. “Isoproterenol enhances phosphorylation of pure β-adrenergic receptor by cAMP-dependent protein kinase.” Federation Proceedings 43, no. 6 (January 1, 1984).
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Shorr, R. G. L., M. W. Strohsacker, P. Nambi, R. J. Lefkowitz, M. G. Caron, and E. S. Kempner. “Determination of the Molecular Size of Frog and Turkey Erythrocyte β-Adrenergic Receptors by Radiation Inactivation.” Biochemistry 23, no. 4 (January 1, 1984): 747–53. https://doi.org/10.1021/bi00299a025.Full Text
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Williams, R. S., M. G. Caron, and K. Daniel. “Skeletal muscle β-adrenergic receptors: Variations due to fiber type and training.” American Journal of Physiology Endocrinology and Metabolism 9, no. 2 (January 1, 1984).
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Cerione, R. A., B. Strulovici, J. L. Benovic, R. J. Lefkowitz, and M. G. Caron. “Pure beta-adrenergic receptor: the single polypeptide confers catecholamine responsiveness to adenylate cyclase.” Nature 306, no. 5943 (December 8, 1983): 562–66. https://doi.org/10.1038/306562a0.Full Text Link to Item
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Kilpatrick, B. F., and M. G. Caron. “Agonist binding promotes a guanine nucleotide reversible increase in the apparent size of the bovine anterior pituitary dopamine receptors.” J Biol Chem 258, no. 22 (November 25, 1983): 13528–34.Link to Item
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Wikberg, J. E., R. J. Lefkowitz, and M. G. Caron. “Solubilization of rat liver alpha 1-adrenergic receptors. Agonist specific alteration in receptor binding affinity.” Biochem Pharmacol 32, no. 21 (November 1, 1983): 3171–78. https://doi.org/10.1016/0006-2952(83)90200-9.Full Text Link to Item
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Wikberg, J. E., M. Akers, M. G. Caron, and P. O. Hagen. “Norepinephrine-induced down regulation of alpha 1 adrenergic receptors in cultured rabbit aorta smooth muscle cells.” Life Sci 33, no. 14 (October 3, 1983): 1409–17. https://doi.org/10.1016/0024-3205(83)90824-x.Full Text Link to Item
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Leeb-Lundberg, L. M., K. E. Dickinson, S. L. Heald, J. E. Wikberg, J. F. DeBernardis, M. Winn, D. L. Arendsen, R. J. Lefkowitz, and M. G. Caron. “Covalent labeling of the cerebral cortex alpha 1-adrenergic receptor with a new high affinity radioiodinated photoaffinity probe.” Biochem Biophys Res Commun 115, no. 3 (September 30, 1983): 946–51. https://doi.org/10.1016/s0006-291x(83)80026-6.Full Text Link to Item
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Stiles, G. L., R. H. Strasser, M. G. Caron, and R. J. Lefkowitz. “Mammalian beta-adrenergic receptors. Structural differences in beta 1 and beta 2 subtypes revealed by peptide maps.” J Biol Chem 258, no. 17 (September 10, 1983): 10689–94.Link to Item
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Cerione, R. A., B. Strulovici, J. L. Benovic, C. D. Strader, M. G. Caron, and R. J. Lefkowitz. “Reconstitution of beta-adrenergic receptors in lipid vesicles: affinity chromatography-purified receptors confer catecholamine responsiveness on a heterologous adenylate cyclase system.” Proc Natl Acad Sci U S A 80, no. 16 (August 1983): 4899–4903. https://doi.org/10.1073/pnas.80.16.4899.Full Text Link to Item
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Stiles, G. L., R. H. Strasser, T. N. Lavin, L. R. Jones, M. G. Caron, and R. J. Lefkowitz. “The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling.” J Biol Chem 258, no. 13 (July 10, 1983): 8443–49.Link to Item
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Heald, S. L., P. W. Jeffs, T. N. Lavin, P. Nambi, R. J. Lefkowitz, and M. G. Caron. “Synthesis of iodine-125 labeled (+/-)-15-(4-azidobenzyl)carazolol: a potent beta-adrenergic photoaffinity probe.” J Med Chem 26, no. 6 (June 1983): 832–38. https://doi.org/10.1021/jm00360a009.Full Text Link to Item
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Stadel, J. M., P. Nambi, R. G. Shorr, D. F. Sawyer, M. G. Caron, and R. J. Lefkowitz. “Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase is associated with phosphorylation of the beta-adrenergic receptor.” Proc Natl Acad Sci U S A 80, no. 11 (June 1983): 3173–77. https://doi.org/10.1073/pnas.80.11.3173.Full Text Link to Item
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Strader, C. D., V. M. Pickel, T. H. Joh, M. W. Strohsacker, R. G. Shorr, R. J. Lefkowitz, and M. G. Caron. “Antibodies to the beta-adrenergic receptor: attenuation of catecholamine-sensitive adenylate cyclase and demonstration of postsynaptic receptor localization in brain.” Proc Natl Acad Sci U S A 80, no. 7 (April 1983): 1840–44. https://doi.org/10.1073/pnas.80.7.1840.Full Text Link to Item
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Stadel, J. M., B. Strulovici, P. Nambi, T. N. Lavin, M. M. Briggs, M. G. Caron, and R. J. Lefkowitz. “Desensitization of the beta-adrenergic receptor of frog erythrocytes. Recovery and characterization of the down-regulated receptors in sequestered vesicles.” J Biol Chem 258, no. 5 (March 10, 1983): 3032–38.Link to Item
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Benovic, J. L., G. L. Stiles, R. J. Lefkowitz, and M. G. Caron. “Photoaffinity labelling of mammalian beta-adrenergic receptors: metal-dependent proteolysis explains apparent heterogeneity.” Biochem Biophys Res Commun 110, no. 2 (January 27, 1983): 504–11. https://doi.org/10.1016/0006-291x(83)91178-6.Full Text Link to Item
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Caron, M. G., B. F. Kilpatrick, and D. R. Sibley. “Direct radioligand measurement of dopamine receptors in the anterior pituitary gland.” Methods Enzymol 103 (1983): 557–90. https://doi.org/10.1016/s0076-6879(83)03041-4.Full Text Link to Item
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Lefkowitz, R. J., J. M. Stadel, and M. G. Caron. “Adenylate cyclase-coupled beta-adrenergic receptors: structure and mechanisms of activation and desensitization.” Annu Rev Biochem 52 (1983): 159–86. https://doi.org/10.1146/annurev.bi.52.070183.001111.Full Text Link to Item
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Stadel, J. M., P. Nambi, R. G. Shorr, D. F. Sawyer, M. G. Caron, and R. J. Lefkowitz. “Phosphorylation of the beta-adrenergic receptor accompanies catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase.” Trans Assoc Am Physicians 96 (1983): 137–45.Link to Item
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Stiles, G. L., B. B. Hoffman, M. Hubbard, M. G. Caron, and R. J. Lefkowitz. “Guanine nucleotides and alpha 1 adrenergic receptors in the heart.” Biochem Pharmacol 32, no. 1 (January 1, 1983): 69–71. https://doi.org/10.1016/0006-2952(83)90654-8.Full Text Link to Item
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Regan, J. W., N. Barden, R. J. Lefkowitz, M. G. Caron, R. M. DeMarinis, A. J. Krog, K. G. Holden, W. D. Matthews, and J. P. Hieble. “Affinity chromatography of human platelet alpha 2-adrenergic receptors.” Proc Natl Acad Sci U S A 79, no. 23 (December 1982): 7223–27. https://doi.org/10.1073/pnas.79.23.7223.Full Text Link to Item
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Shorr, R. G. L., M. W. Strohsacker, T. N. Lavin, R. J. Lefkowitz, and M. G. Caron. “The β1-adrenergic receptor of the turkey erythrocyte. Molecular heterogeneity revealed by purification and photoaffinity labeling.” Journal of Biological Chemistry 257, no. 20 (December 1, 1982): 12341–50.
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Lavin, T. N., P. Nambi, S. L. Heald, P. W. Jeffs, R. J. Lefkowitz, and M. G. Caron. “125I-labeled p-azidobenzylcarazolol, a photoaffinity label for the beta-adrenergic receptor. Characterization of the ligand and photoaffinity labeling of beta 1- and beta 2-adrenergic receptors.” J Biol Chem 257, no. 20 (October 25, 1982): 12332–40.Link to Item
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Shorr, R. G., M. W. Strohsacker, T. N. Lavin, R. J. Lefkowitz, and M. G. Caron. “The beta 1-adrenergic receptor of the turkey erythrocyte. Molecular heterogeneity revealed by purification and photoaffinity labeling.” J Biol Chem 257, no. 20 (October 25, 1982): 12341–50.Link to Item
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De Lean, A., B. F. Kilpatrick, and M. G. Caron. “Dopamine receptor of the porcine anterior pituitary gland. Evidence for two affinity states discriminated by both agonists and antagonists.” Mol Pharmacol 22, no. 2 (September 1982): 290–97.Link to Item
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Kilpatrick, B. F., A. De Lean, and M. G. Caron. “Dopamine receptor of the porcine anterior pituitary gland. Effects of N-ethylmaleimide and heat on ligand binding mimic the effects of guanine nucleotides.” Mol Pharmacol 22, no. 2 (September 1982): 298–303.Link to Item
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Stadel, J. M., P. Nambi, T. N. Lavin, S. L. Heald, M. G. Caron, and R. J. Lefkowitz. “Catecholamine-induced desensitization of turkey erythrocyte adenylate cyclase. Structural alterations in the beta-adrenergic receptor revealed by photoaffinity labeling.” J Biol Chem 257, no. 16 (August 25, 1982): 9242–45.Link to Item
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Lefkowitz, R. J., M. G. Caron, T. Michel, and J. M. Stadel. “Mechanisms of hormone receptor-effector coupling: the beta-adrenergic receptor and adenylate cyclase.” Fed Proc 41, no. 10 (August 1982): 2664–70.Link to Item
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Caron, M. G., R. G. Shorr, T. N. Lavin, and R. J. Lefkowitz. “Molecular characterization of the beta-adrenergic receptor of frog erythrocytes.” Metabolism 31, no. 7 (July 1982): 658–63. https://doi.org/10.1016/0026-0495(82)90195-0.Full Text Link to Item
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Shorr, R. G., S. L. Heald, P. W. Jeffs, T. N. Lavin, M. W. Strohsacker, R. J. Lefkowitz, and M. G. Caron. “The beta-adrenergic receptor: rapid purification and covalent labeling by photoaffinity crosslinking.” Proc Natl Acad Sci U S A 79, no. 9 (May 1982): 2778–82. https://doi.org/10.1073/pnas.79.9.2778.Full Text Link to Item
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De Lean, A., B. F. Kilpatrick, and M. G. Caron. “Guanine nucleotides regulate both dopaminergic agonist and antagonist binding in porcine anterior pituitary.” Endocrinology 110, no. 3 (March 1982): 1064–66. https://doi.org/10.1210/endo-110-3-1064.Full Text Link to Item
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Caron, M. G., R. G. L. Shorr, and E. S. Kempner. “The β2 adrenergic receptor of frog erythrocytes: Rapid purification, photoaffinity labelling and molecular characterization.” Federation Proceedings 41, no. 5 (January 1, 1982).
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Caron, M. G., R. G. L. Shorr, and E. S. Kempner. “The β2 adrenergic receptor of frog erythrocytes: Rapid purification, photoaffinity labelling and molecular characterization.” Federation Proceedings 41, no. 5 (1982): No.-7388.
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Shorr, R. G. L., M. W. Strohsacker, T. N. Lavin, R. J. Lefkowitz, and M. G. Caron. “The β1-adrenergic receptor of the turkey erythrocyte. Molecular heterogeneity revealed by purification and photoaffinity labeling.” Journal of Biological Chemistry 257, no. 20 (1982): 12341–50.
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Lavin, T. N., S. L. Heald, P. W. Jeffs, R. G. Shorr, R. J. Lefkowitz, and M. G. Caron. “Photoaffinity labeling of the beta-adrenergic receptor.” J Biol Chem 256, no. 22 (November 25, 1981): 11944–50.Link to Item
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Michel, T., B. B. Hoffman, R. J. Lefkowitz, and M. G. Caron. “Different sedimentation properties of agonist- and antagonist-labelled platelet alpha 2 adrenergic receptors.” Biochem Biophys Res Commun 100, no. 3 (June 16, 1981): 1131–36. https://doi.org/10.1016/0006-291x(81)91941-0.Full Text Link to Item
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Shorr, R. G., R. J. Lefkowitz, and M. G. Caron. “Purification of the beta-adrenergic receptor. Identification of the hormone binding subunit.” J Biol Chem 256, no. 11 (June 10, 1981): 5820–26.Link to Item
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Caron, M. G., R. G. Shorr, R. J. Lefkowitz, S. L. Heald, P. W. Jeffs, J. Zjawiony, and J. Pitha. “Isolation and characterization of the beta-adrenergic receptor of frog erythrocytes and development of potential affinity ligands.” Adv Cyclic Nucleotide Res 14 (1981): 127–34.Link to Item
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Kilpatrick, B. F., A. De Lean, and M. G. Caron. “Differential effects of n-ethylmaleimide on dopaminergic agonist and antagonist binding in porcine anterior pituitary.” Federation Proceedings 40, no. 6 (January 1, 1981): 1634.
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Shorr, R. G. L., M. G. Caron, and R. J. Lefkowitz. “Molecular properties of the purified beta-adrenergic receptor.” Federation Proceedings 40, no. 6 (January 1, 1981): 1633.
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Pitha, J., J. Zjawiony, N. Nasrin, R. J. Lefkowitz, and M. G. Caron. “Potent beta-adrenergic antagonist possessing chemically reactive group.” Life Sci 27, no. 19 (November 10, 1980): 1791–98. https://doi.org/10.1016/0024-3205(80)90447-6.Full Text Link to Item
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Schocken, D. D., M. G. Caron, and R. J. Lefkowitz. “The human placenta--a rich source of beta-adrenergic receptors: characterization of the receptors in particulate and solubilized preparations.” J Clin Endocrinol Metab 50, no. 6 (June 1980): 1082–88. https://doi.org/10.1210/jcem-50-6-1082.Full Text Link to Item
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Pitha, J., J. Zjawiony, R. J. Lefkowitz, and M. G. Caron. “Macromolecular beta-adrenergic antagonists discriminating between receptor and antibody.” Proc Natl Acad Sci U S A 77, no. 4 (April 1980): 2219–23. https://doi.org/10.1073/pnas.77.4.2219.Full Text Link to Item
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Caron, M. G., Y. Srinivasan, and R. J. Lefkowitz. “Affinity chromatography of the beta-adrenergic receptor and characterization of antibodies raised against purified receptor preparations.” Adv Biochem Psychopharmacol 21 (1980): 151–58.Link to Item
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Caron, M. G., L. E. Limbird, and R. J. Lefkowitz. “Biochemical characterization of the beta-adrenergic receptor of the frog erythrocyte.” Mol Cell Biochem 28, no. 1–3 (December 14, 1979): 45–66. https://doi.org/10.1007/BF00223359.Full Text Link to Item
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Wood, C. L., M. G. Caron, and R. J. Lefkowitz. “Separation of solubilized alpha and beta adrenergic receptors by affinity chromatography.” Biochem Biophys Res Commun 88, no. 1 (May 14, 1979): 1–8. https://doi.org/10.1016/0006-291x(79)91688-7.Full Text Link to Item
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Caron, M. G., Y. Srinivasan, R. Snyderman, and R. J. Lefkowitz. “Antibodies raised against purified beta-adrenergic receptors specifically bind beta-adrenergic ligands.” Proc Natl Acad Sci U S A 76, no. 5 (May 1979): 2263–67. https://doi.org/10.1073/pnas.76.5.2263.Full Text Link to Item
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Caron, M. G., Y. Srinivasan, J. Pitha, K. Kociolek, and R. J. Lefkowitz. “Affinity chromatography of the beta-adrenergic receptor.” J Biol Chem 254, no. 8 (April 25, 1979): 2923–27.Link to Item
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Pitha, J., K. Kociolek, and M. G. Caron. “Detergents linked to polysaccharides: preparation and effects on membranes and cells.” Eur J Biochem 94, no. 1 (February 15, 1979): 11–18. https://doi.org/10.1111/j.1432-1033.1979.tb12865.x.Full Text Link to Item
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Caron, M. G., Y. Srinivasan, R. Snyderman, and R. J. Lefkowitz. “Antibodies raised against purified β-adrenergic receptors recognize β-adrenergic ligands.” Clinical Research 27, no. 2 (January 1, 1979).
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Pitha, J., M. G. Caron, and R. J. Lefkowitz. “POLYMERIC DRUG BY DIRECT CO-POLYMERIZATION: POLYMER OF beta -ADRENERGIC ANTAGONIST AND ITS BINDING TO RECEPTOR AND ANTIBODY.” American Chemical Society, Polymer Preprints, Division of Polymer Chemistry 20, no. 2 (January 1, 1979): 652–53.
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Schocken, D. D., M. G. Caron, and R. J. Lefkowitz. “An unusually rich source of beta-adrenergic receptors-human placenta: Characterization in membrane-bound and solubilized fractions.” Clinical Research 27, no. 5 (January 1, 1979).
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Wood, C., M. G. Caron, and R. J. Lefkowitz. “Separation of solubilized alpha and beta-adrenergic receptors by affinity chromatography.” Clinical Research 27, no. 2 (January 1, 1979).
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Caron, M. G., M. Beaulieu, V. Raymond, B. Gagné, J. Drouin, R. J. Lefkowitz, and F. Labrie. “Dopaminergic receptors in the anterior pituitary gland. Correlation of [3H]dihydroergocryptine binding with the dopaminergic control of prolactin release.” J Biol Chem 253, no. 7 (April 10, 1978): 2244–53.Link to Item
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Bukowiecki, L. J., M. G. Caron, J. Vallieres, and J. LeBlanc. “beta-adrenergic receptors in brown adipose tissue: identification by (-)[3H]dihydroalprenolol binding.” Experientia Suppl 32 (1978): 55–59. https://doi.org/10.1007/978-3-0348-5559-4_5.Full Text Link to Item
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Labrie, F., J. Drouin, L. Ferland, L. Lagacé, M. Beaulieu, A. De Léan, P. A. Kelly, M. G. Caron, and V. Raymond. “Mechanism of action of hypothalamic hormones in the anterior pituitary gland and specific modulation of their activity by sex steroids and thyroid hormones.” Recent Prog Horm Res 34 (1978): 25–93. https://doi.org/10.1016/b978-0-12-571134-0.50006-5.Full Text Link to Item
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Williams, M. T., M. R. Clark, W. Y. Ling, W. J. LeMaire, M. G. Caron, and J. M. Marsh. “Role of cyclic AMP in the actions of luteinizing hormone on steroidogenesis in the corpus luteum.” Adv Cyclic Nucleotide Res 9 (1978): 573–82.Link to Item
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Asselin, J., P. A. Kelly, M. G. Caron, and F. Labrie. “Control of hormone receptor levels and growth of 7,12-dimethylbenz(a)anthracene-induced mammary tumors by estrogens, progesterone and prolactin.” Endocrinology 101, no. 3 (September 1977): 666–71. https://doi.org/10.1210/endo-101-3-666.Full Text Link to Item
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Caron, M. G., B. Gagne, and A. De Lean. “Identification of beta adrenergic receptors in rat hypothalamus.” Can J Biochem 55, no. 7 (July 1977): 693–99. https://doi.org/10.1139/o77-100.Full Text Link to Item
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Kelly, P. A., J. Asselin, M. G. Caron, F. Labrie, and J. P. Raynaud. “Potent inhibitory effect of a new antiestrogen (RU 16117) on the growth of 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors.” J Natl Cancer Inst 58, no. 3 (March 1977): 623–28. https://doi.org/10.1093/jnci/58.3.623.Full Text Link to Item
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Caron, M. G., V. Raymond, R. J. Lefkowitz, and F. Labrie. “Identification of dopaminergic receptors in anterior pituitary: correlation with the dopaminergic control of prolactin release.” Federation Proceedings 36, no. 3 (January 1, 1977).
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Kelly, P. A., J. Asselin, M. G. Caron, J. P. Raynaud, and F. Labrie. “High inhibitory activity of a new antiestrogen, RU 16117 (11alpha-methoxy ethinyl estradiol), on the development of dimethylbenz(a)anthracene-induced mammary tumors.” Cancer Res 37, no. 1 (January 1977): 76–81.Link to Item
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Lefkowitz, R. J., C. Mukherjee, and M. Caron. “Biochemical mechanisms for regulation of β adrenergic receptors by β adrenergic agonists.” Excerpta Medica,Amsterdam,Ics No. 402 (1977): 502–6.
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Morin, O., M. G. Caron, A. De Lean, and F. Labrie. “Binding of the opiate-like pentapeptide methionine-enkephalin to a particulate fraction from rat brain.” Biochemical and Biophysical Research Communications 73, no. 4 (December 20, 1976): 940–46. https://doi.org/10.1016/0006-291X(76)90212-6.Full Text
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Caron, M. G., and R. J. Lefkowitz. “Biological activity of agarose-immobilized catecholamines.” Biochim Biophys Acta 444, no. 2 (September 24, 1976): 472–86. https://doi.org/10.1016/0304-4165(76)90391-3.Full Text Link to Item
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Lefkowitz, R. J., D. Mullikin, and M. G. Caron. “Regulation of beta-adrenergic receptors by guanyl-5'-yl imidodiphosphate and other purine nucleotides.” J Biol Chem 251, no. 15 (August 10, 1976): 4686–92.Link to Item
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Mukherjee, C., M. G. Caron, and R. J. Lefkowitz. “Regulation of adenylate cyclase coupled beta-adrenergic receptors by beta-adrenergic catecholamines.” Endocrinology 99, no. 2 (August 1976): 347–57. https://doi.org/10.1210/endo-99-2-347.Full Text Link to Item
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Caron, M. G., and R. J. Lefkowitz. “Solubilization and characterization of the beta-adrenergic receptor binding sites of frog erythrocytes.” J Biol Chem 251, no. 8 (April 25, 1976): 2374–84.Link to Item
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Lefkowitz, R. J., L. E. Limbird, C. Mukherjee, and M. G. Caron. “The beta-adrenergic receptor and adenylate cyclase.” Biochim Biophys Acta 457, no. 1 (April 13, 1976): 1–39. https://doi.org/10.1016/0304-4157(76)90012-5.Full Text Link to Item
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Caron, M. G., and R. J. Lefkowitz. “Beta-Adrenergic receptors: solubilization of (-)(3H)alprenolol binding sites from frog erythrocyte membranes.” Biochem Biophys Res Commun 68, no. 2 (January 26, 1976): 315–22. https://doi.org/10.1016/0006-291x(76)91145-1.Full Text Link to Item
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Caron, M. G., J. Drouin, and V. Raymond. “Specificity of the catecholaminergic effect on prolactin secretion and (3H) dihydroergocryptine binding.” Clinical Research 24, no. 5 (January 1, 1976).
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Lefkowitz, R. J., C. Mukherjee, L. E. Limbird, M. G. Caron, L. T. Williams, R. W. Alexander, J. V. Mickey, and R. Tate. “Regulation of adenylate cyclase coupled beta-adrenergic receptors.” Recent Prog Horm Res 32 (1976): 597–632. https://doi.org/10.1016/b978-0-12-571132-6.50033-6.Full Text Link to Item
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Morin, O., M. G. Caron, and A. De Lean. “Binding of the opiate like pentapeptide methionine enkephalin and analogs to rat brain membranes.” Clinical Research 24, no. 5 (January 1, 1976).
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Mukherjee, C., M. G. Caron, D. Mullikin, and R. J. Lefkowitz. “Structure-activity relationships of adenylate cyclase-coupled beta adrenergic receptors: determination by direct binding studies.” Mol Pharmacol 12, no. 1 (January 1976): 16–31.Link to Item
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Caron, M. G., S. Goldstein, K. Savard, and J. M. Marsh. “Protein kinase stimulation of a reconstituted cholesterol side chain cleavage enzyme system in the bovine corpus luteum.” J Biol Chem 250, no. 13 (July 10, 1975): 5137–43.Link to Item
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Mukherjee, C., M. G. Caron, M. Coverstone, and R. J. Lefkowitz. “Identification of adenylate cyclase-coupled beta-adrenergic receptors in frog erythrocytes with (minus)-[3-H] alprenolol.” J Biol Chem 250, no. 13 (July 10, 1975): 4869–76.Link to Item
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Lefkowitz, R. J., and M. G. Caron. “Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase.” J Biol Chem 250, no. 12 (June 25, 1975): 4418–22.Link to Item
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Mukherjee, C., M. G. Caron, and R. J. Lefkowitz. “Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites.” Proc Natl Acad Sci U S A 72, no. 5 (May 1975): 1945–49. https://doi.org/10.1073/pnas.72.5.1945.Full Text Link to Item
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Mukherjee, C., M. G. Caron, and R. J. Lefkowitz. “Catecholamine induced subsensitivity of adenylate cyclase coupled β adrenergic receptors.” Clinical Research 23, no. 3 (January 1, 1975).
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Mukherjee, C., M. G. Caron, and R. J. Lefkowitz. “Stereospecific [3H](-) alprenolol binding sites and adenylate cyclase coupled β adrenergic receptors in frog erythrocyte membranes.” Federation Proceedings 34, no. 3 (January 1, 1975).
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Lefkowitz, R. J., C. Mukherjee, M. Coverstone, and M. G. Caron. “Stereospecific (3H)(minus)-alprenolol binding sites, beta-adrenergic receptors and adenylate cyclase.” Biochem Biophys Res Commun 60, no. 2 (September 23, 1974): 703–9. https://doi.org/10.1016/0006-291x(74)90297-6.Full Text Link to Item
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Caron, M. G., and R. J. Lefkowitz. “Temperature immutability of adenyl cyclase-coupled beta adrenergic receptors.” Nature 249, no. 454 (May 17, 1974): 258–60. https://doi.org/10.1038/249258a0.Full Text Link to Item
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Caron, M. G., and R. J. Lefkowitz. “Biological activity of agarose immobilized catecholamines: new tool for the localization of β adrenergic receptors.” Circulation 50, no. 4 sup.3 (January 1, 1974).
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Book Sections
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Caron, M. G., and R. R. Gainetdinov. “Role of Dopamine Transporters in Neuronal Homeostasis.” In Dopamine Handbook, 2010. https://doi.org/10.1093/acprof:oso/9780195373035.003.0007.Full Text
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Laakso, A., and M. G. Caron. “Dopamine Receptors.” In Primer on the Autonomic Nervous System: Second Edition, 39–43, 2004. https://doi.org/10.1016/B978-012589762-4/50010-4.Full Text
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Conference Papers
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Lajiness, M. E., C. L. Chio, R. M. Huff, M. G. Caron, C. A. Tamminga, H. H. M. Van Tol, A. Carlsson, J. C. Schwartz, and M. F. Piercey. “Signaling mechanisms of D2, D3, and D4 dopamine receptors determined in transfected cell lines.” In Clinical Neuropharmacology, Vol. 18, 1995. https://doi.org/10.1097/00002826-199501001-00004.Full Text
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- Teaching & Mentoring
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Recent Courses
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- PHARM 394: Research Independent Study 2021
- PHARM 493: Research Independent Study 2021
- BIOCHEM 761: Cellular Signaling Module I: GPCR Signaling and Disease 2020
- BIOCHEM 762: Cellular Signaling Module II: Intracellular Signaling and Disease 2020
- BIOCHEM 763: Cellular Signaling Module III: Growth Factor Pathway in Development and Disease 2020
- CELLBIO 493: Research Independent Study 2020
- CELLBIO 761: Cellular Signaling Module I: GPCR Signaling and Disease 2020
- CELLBIO 762: Cellular Signaling Module II: Intracellular Signaling and Disease 2020
- CELLBIO 763: Cellular Signaling Module III: Growth Factor Pathway in Development and Disease 2020
- MOLCAN 761: Cellular Signaling Module I: GPCR Signaling and Disease 2020
- MOLCAN 762: Cellular Signaling Module II: Intracellular Signaling and Disease 2020
- MOLCAN 763: Cellular Signaling Module III: Growth Factor Pathway in Development and Disease 2020
- NEUROBIO 393: Research Independent Study 2020
- NEUROBIO 793: Research in Neurobiology 2020
- PHARM 393: Research Independent Study 2020
- PHARM 394: Research Independent Study 2020
- PHARM 493: Research Independent Study 2020
- PHARM 761: Cellular Signaling Module I: GPCR Signaling and Disease 2020
- PHARM 762: Cellular Signaling Module II: Intracellular Signaling and Disease 2020
- PHARM 763: Cellular Signaling Module III: Growth Factor Pathway in Development and Disease 2020
- BIOCHEM 761: Cellular Signaling Module I: GPCR Signaling and Disease 2019
- BIOCHEM 762: Cellular Signaling Module II: Intracellular Signaling and Disease 2019
- BIOCHEM 763: Cellular Signaling Module III: Growth Factor Pathway in Development and Disease 2019
- CELLBIO 493: Research Independent Study 2019
- CELLBIO 761: Cellular Signaling Module I: GPCR Signaling and Disease 2019
- CELLBIO 762: Cellular Signaling Module II: Intracellular Signaling and Disease 2019
- CELLBIO 763: Cellular Signaling Module III: Growth Factor Pathway in Development and Disease 2019
- MOLCAN 761: Cellular Signaling Module I: GPCR Signaling and Disease 2019
- MOLCAN 762: Cellular Signaling Module II: Intracellular Signaling and Disease 2019
- MOLCAN 763: Cellular Signaling Module III: Growth Factor Pathway in Development and Disease 2019
- NEUROSCI 495: Research Independent Study 3 2019
- PHARM 393: Research Independent Study 2019
- PHARM 394: Research Independent Study 2019
- PHARM 493: Research Independent Study 2019
- PHARM 761: Cellular Signaling Module I: GPCR Signaling and Disease 2019
- PHARM 762: Cellular Signaling Module II: Intracellular Signaling and Disease 2019
- PHARM 763: Cellular Signaling Module III: Growth Factor Pathway in Development and Disease 2019
- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
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