Overview
Dr. Kayle’s program of research aims to improve health outcomes among people with childhood-onset complex chronic conditions, with a focus on sickle cell disease (SCD). In partnership with the North Carolina Department of Health and Human Services, Division of Public Health, she co-leads the North Carolina Sickle Cell Data Collection Program (NC SCDC), a state-level surveillance program funded by the Centers for Disease Control and Prevention. NC SCDC curates and analyzes multi-source, population-level datasets to describe the epidemiology, health outcomes, and social determinants of health influencing SCD. Dr. Kayle collaborates with national and state partners to disseminate surveillance findings informing practice, research, and policy for SCD.
Dr. Kayle teaches and mentors students enrolled in the Doctor of Nursing Practice (DNP) and the Doctor of Philosophy in Nursing (PhD) programs at the School of Nursing. Her service contributions include several state and national committees on SCD.
Dr. Kayle completed her Bachelor of Science in Nursing at the American University of Beirut, her Master's in Pediatric Acute and Critical Care and her Doctor of Philosophy in Nursing at Duke University School of Nursing, and her Postdoctoral Fellowship in Health Services and Outcomes Research at Northwestern University, Feinberg School of Medicine. She has over twelve years of pediatric acute and critical care clinical experience, including six years in hospital administration and quality improvement.
Current Appointments & Affiliations
In the News
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Recent Publications
Acute Care Use Among People With Sickle Cell Disease, Sickle Cell Data Collection Program, 8 US States, 2018.
Journal Article Public health reports (Washington, D.C. : 1974) · November 2025 ObjectivesUnderstanding patterns of hospital admissions and emergency department (ED) visits among people with sickle cell disease is critical for improving care and access to care for this population. The objective of this study was to characteri ... Full text Open Access CitePregnancy- and Disease-Related Morbidity Among Medicaid Enrollees With Sickle Cell Disease.
Journal Article Pediatric blood & cancer · September 2025 BackgroundWhereas pregnancy in sickle cell disease (SCD) is considered high risk, there is limited understanding of pregnancy- and SCD-related morbidity to inform clinical practice and health policy.ProcedureThis retrospective cohort stud ... Full text CiteRedefining High Emergency Department Utilization for Sickle Cell Disease.
Journal Article JAMA Netw Open · June 2, 2025 IMPORTANCE: Sickle cell disease (SCD) is a complex hemoglobinopathy. Vaso-occlusive episodes are the primary cause of emergency department (ED) utilization among individuals with SCD. Literature lacks a standardized definition for high ED utilization. OBJE ... Full text Link to item CiteRecent Grants
North Carolina Sickle Cell Data Collection
Public ServicePrincipal Investigator · Awarded by NC Department of Health and Human Services · 2024 - 2024NCDHHS Sickle Cell Data Collection Program in North Carolina Year 3
Public ServicePrincipal Investigator · Awarded by NC Department of Health and Human Services · 2022 - 2023Improving SCD Care using Web-based Guidelines, Nurse Care Managers and Peer Mentors in Parimary Care Emergency Departments in Central North Carolina
ResearchCo Investigator · Awarded by National Institutes of Health · 2016 - 2023View All Grants