Mark Gage | Scholars@Duke

Mark Gage
Assistant Professor of Orthopaedic Surgery

I am an orthopaedic surgeon here at Duke specializing in the care of orthopaedic trauma, complex fractures, limb reconstruction, shoulder arthroplasty, osteomyelitis, and post-traumatic pathology including limb deformity, fracture non-union, and arthritis.

Current Research Interests

Patient activity and bone healing
Clinical outcomes after extremity trauma and orthopaedic intervention
Osteomyelitis treatment strategies
Postoperative pain control after orthopaedic surgery - exploring non-narcotic treatment options
The effects of orthopaedic surgery and extremity implants on bone remodeling
Orthopaedic fracture fixation strategies and their influence on bone healing/remodeling

Current Appointments & Affiliations

Assistant Professor of Orthopaedic Surgery, Orthopaedics, Orthopaedics 2021

Contact Information

311 Trent Drive, Durham, NC 27710
mark.gage@duke.edu (919) 668-0291

Background
Education, Training, & Certifications
- Fellowship: Traumatology and Reconstructive Surgery, Orthopaedic Surgery, University of Maryland School of Medicine 2016 - 2017
- Residency, Orthopaedic Surgery, NYU Langone Orthopedic Hospital 2011 - 2016
- M.D., New York University School of Medicine 2011
Previous Appointments & Affiliations
- Assistant Professor of Orthopaedic Surgery, Orthopaedics, Orthopaedics 2017 - 2020
Recognition
Awards & Honors
Expertise
Subject Headings
Global Scholarship
- Research
  - United States of America (Country)
- Teaching
  - United States of America (Country)
Research
Selected Grants
- Safety, Efficacy, & Use of Vivigen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care awarded by LifeNet Health 2020 - 2024
- Deep Learning for Automated Fracture Detection awarded by Piedmont Orthopedic Foundation 2022
- Opioid use after proximal humerus fracture awarded by Piedmont Orthopedic Foundation 2021
- Postoperative Morbidity and Mortality for Hip Fracture Patient's with Chronic Liver Disease awarded by Piedmont Orthopedic Foundation 2019 - 2021
- Fresh Tissue Lab Agreement awarded by DePuy Synthes Companies 2021
- PREPARE: A Pragmatic Randomized trial Evaluating Pre-operative Alcohol skin solutions in FRactured Extremities awarded by University of Maryland 2018 - 2021
- Fresh Tissue Lab Agreement awarded by Smith & Nephew, Inc 2020
- Fresh Tissue Lab Agreement awarded by IlluminOss Medical, Inc. 2020
- Development of a Patient-Reported Outcome Instrument for Severe Lower Extremity Trauma: Cognitive Debriefing Interviews awarded by Foundation for Orthopedic Trauma 2018 - 2020
- Fresh Tissue Lab Agreement awarded by Tornier, Inc. 2018
Fellowships, Supported Research, & Other Grants
- Kathy Cramer Young Clinician Memorial Scholarship awarded by Orthopaedic Trauma Association 2017
- Development of a PRO Instrument for Use in Severe Lower Extremity Trauma awarded by Duke Surgical Center for Outcomes Research Grant 2017 - 2018
- Identifying predictors for long-term success or failure of pilon fractures after surgical fixation awarded by AO Trauma North America Fellows Grant 2016
- Can We Better Monitor Hip Fracture Recovery? Advanced Tracking Devices in the Early Postoperative Period awarded by Orthopaedic Research and Education Foundation Resident Grant 2015
External Relationships
- Arthrex, Inc.
- Book royalties from Spinger and Elsevier
- Trackx Technology LLC
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Cunningham DJ, LaRose MA, Zhang GX, Au S, MacAlpine EM, Paniagua AR, et al. Regional anesthesia reduces inpatient and outpatient perioperative opioid demand in periarticular elbow surgery. J Shoulder Elbow Surg. 2022 Feb;31(2):e48–57.
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  - Sprague S, Guyatt P, Bzovsky S, Nguyen U, Bhandari M, Thabane L, et al. Pragmatic randomized trial evaluating pre-operative aqueous antiseptic skin solution in open fractures (Aqueous-PREP): the feasibility of a cluster randomized crossover study. Pilot and Feasibility Studies. 2021 Dec;7(1).
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  - Cunningham DJ, Blatter M, Adams SB, Gage MJ. State regulation positively impacts opioid prescribing patterns in ankle fracture surgery: A national and state-level analysis. Injury. 2021 Nov 17;
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  - Cunningham D, LaRose M, Zhang G, Au S, MacAlpine E, Paniagua A, et al. Regional Anesthesia Reduces Inpatient and Outpatient Perioperative Opioid Demand in Peri-articular Elbow Surgery. J Shoulder Elbow Surg. 2021 Nov 11;
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  - Saltzman EB, Evans DR, Anastasio A, Guisse N, Belay ES, Anakwenze OA, et al. Use of a 5-item modified Fragility Index for risk stratification in patients undergoing surgical management of distal humerus fractures. Jses Int. 2021 Nov;5(6):1111–8.
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  - Cunningham DJ, LaRose MA, DeLaura IF, Zhang GX, Paniagua AR, Gage MJ. Regional anesthesia does not decrease inpatient or outpatient opioid demand in femoral shaft fracture surgery. Injury. 2021 Oct;52(10):3075–84.
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  - O’Donnell JA, Gage MJ. Proximal Humerus Geriatric Fracture Care: Fix, Replace, or Nonoperative Treatment? J Orthop Trauma. 2021 Oct 1;35(Suppl 5):S6–10.
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  - Cunningham DJ, Robinette JP, Paniagua AR, LaRose MA, Blatter M, Gage MJ. Regional anesthesia does not decrease opioid demand in pelvis and acetabulum fracture surgery. Eur J Orthop Surg Traumatol. 2021 Sep 14;
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  - Mundy LR, Klassen A, Pusic AL, Hollenbeck ST, Gage MJ. Reply: Identifying Factors Most Important to Lower Extremity Trauma Patients: Key Concepts from the Development of a Patient-Reported Outcome Instrument for Lower Extremity Trauma, The LIMB-Q. Plast Reconstr Surg. 2021 Sep 1;148(3):510e-511e.
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  - Sharma A, Whitlock KG, Gage MJ, Lassiter TE, Anakwenze OA, Klifto CS. Malpractice trends in shoulder and elbow surgery. Journal of Shoulder and Elbow Surgery. 2021 Sep;30(9):2007–13.
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  - LaRose M, Cunningham D, Paniagua A, Gage M. Long-Term Post Traumatic Stress Disorder after Orthopaedic Injury: Prevalence and Risk Factors. Journal of Orthopaedic Trauma. 2021 Aug 25;
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  - Cunningham DJ, LaRose MA, Anakwenze OA, Klifto CS, Richard MJ, Ruch DS, et al. Fracture location impacts opioid demand in upper extremity fracture surgery. Injury. 2021 Aug;52(8):2314–21.
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  - Cunningham D, LaRose M, Yoon RS, Gage MJ. Factors associated with perioperative opioid demand in lower extremity fractures: Does consumption vary by anatomic location? Injury. 2021 Jun;52(6):1363–9.
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  - Pechero G, Pfaff B, Rao M, Pogorzelski D, McKay P, Spicer E, et al. Implementing stakeholder engagement to explore alternative models of consent: An example from the PREP-IT trials. Contemporary Clinical Trials Communications. 2021 Jun 1;22.
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  - Cunningham DJ, Paniaugua AR, LaRose MA, DeLaura IF, Blatter MK, Gage MJ. Regional anesthesia does not decrease inpatient or outpatient opioid demand in distal femur fracture surgery. Arch Orthop Trauma Surg. 2021 May 3;
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  - Cunningham DJ, LaRose MA, Gage MJ. Impact of Substance Use and Abuse on Opioid Demand in Lower Extremity Fracture Surgery. J Orthop Trauma. 2021 May 1;35(5):e171–6.
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  - Lin CA, O’Hara NN, Sprague S, O’Toole RV, Joshi M, Harris AD, et al. Low Adherence to Recommended Guidelines for Open Fracture Antibiotic Prophylaxis. Journal of Bone and Joint Surgery. 2021 Apr 7;103(7):609–17.
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  - Cunningham DJ, LaRose MA, Gage MJ. The Impact of Mental Health and Substance Use on Opioid Demand After Hip Fracture Surgery. J Am Acad Orthop Surg. 2021 Apr 1;29(7):e354–62.
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  - Saltzman EB, Belay E, Federer AE, French R, Anakwenze O, Gage MJ, et al. Humeral intramedullary nail placement through the rotator interval: an anatomic and radiographic analysis. J Shoulder Elbow Surg. 2021 Apr;30(4):747–55.
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  - Cunningham DJ, LaRose MA, Klifto CS, Gage MJ. Mental health and substance use affect perioperative opioid demand in upper extremity trauma surgery. J Shoulder Elbow Surg. 2021 Mar;30(3):e114–20.
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  - Evans DR, Saltzman EB, Anastasio AT, Guisse NF, Belay ES, Pidgeon TS, et al. Use of a 5-item modified Fragility Index for risk stratification in patients undergoing surgical management of proximal humerus fractures. Jses Int. 2021 Mar;5(2):212–9.
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  - Pogorzelski D, Nguyen U, McKay P, Thabane L, Camara M, Ramsey L, et al. Managing work flow in high enrolling trials: The development and implementation of a sampling strategy in the PREPARE trial. Contemporary Clinical Trials Communications. 2021 Mar 1;21.
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  - Pizzo RA, Gianakos AL, Haring RS, Gage MJ, Stevens NM, Liporace FA, et al. Are Arthroplasty Procedures Really Better in the Treatment of Complex Proximal Humerus Fractures? A Comprehensive Meta-Analysis and Systematic Review. J Orthop Trauma. 2021 Mar 1;35(3):111–9.
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  - Anastasio AT, Patel PS, Fernandez-Moure J, Gage MJ. A Solution to After-Hours Fatigue and Surgical Backlog. Geriatr Orthop Surg Rehabil. 2021;12:2151459321989523.
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  - Cunningham DJ, LaRose ML, DeLaura IF, Zhang GX, Klifto CS, Gage MJ. Legislation Only Limiting Opioid Prescription Length Has Minimal Impact on Prescribing in Orthopaedic Trauma. J Surg Orthop Adv. 2021;30(2):101–7.
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  - Mundy LR, Truong T, Shammas RL, Cunningham D, Hollenbeck ST, Pomann G-M, et al. Amputation Rates in More Than 175,000 Open Tibia Fractures in the United States. Orthopedics. 2021 Jan 1;44(1):48–53.
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  - Ryan SP, Adams SB, Allen N, Lazarides AL, Wellman SS, Gage MJ. Intraoperative Fire Risk: Evaluating the 3-Minute Wait After Chlorhexidine-Alcohol Antiseptic Scrub. J Orthop Trauma. 2021 Jan 1;35(1):e31–3.
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  - Cunningham DJ, LaRose MA, Zhang GX, Paniagua AR, Klifto CS, Gage MJ. Beware the rebound effect: regional anesthesia increases opioid utilization after humerus fracture surgery. Shoulder and Elbow. 2021 Jan 1;
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  - Mundy LR, Klassen A, Sergesketter AR, Grier AJ, Carty MJ, Hollenbeck ST, et al. Content Validity of the LIMB-Q: A Patient-Reported Outcome Instrument for Lower Extremity Trauma Patients. J Reconstr Microsurg. 2020 Nov;36(9):625–33.
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  - Hale D, Marvel D, Wells J, PREP-IT Investigators. What's Important: Patient Engagement in Research. J Bone Joint Surg Am. 2020 Oct 21;102(20):1836–8.
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  - Sprague S, Scott T, Dodds S, Pogorzelski D, McKay P, Harris AD, et al. Correction to: Cluster identification, selection, and description in Cluster randomized crossover trials: the PREP-IT trials. Trials. 2020 Sep 30;21(1):821.
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  - Ryan SP, Padilla JA, Schwarzkopf R, Gage MJ, Bolognesi MP, Seyler TM. Arthroplasty Surgeons Do Not Improve Acute Outcomes for Patients With Hip Fracture Relative to Other Subspecialists. Orthopedics. 2020 Sep 1;43(5):e442–6.
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  - Mundy LR, Klassen A, Grier AJ, Gibbons C, Lane W, Carty MJ, et al. Identifying Factors Most Important to Lower Extremity Trauma Patients: Key Concepts from the Development of a Patient-Reported Outcome Instrument for Lower Extremity Trauma, The LIMB-Q. Plast Reconstr Surg. 2020 May;145(5):1292–301.
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  - Costales T, Shannon SF, Gage MJ, Manson TT. Current Treatments of Tibial Surgical Site Infection and Osteomyelitis after Fracture Surgery. Techniques in Orthopaedics. 2020 Jan 1;35(2):117–22.
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  - Danilkowicz R, Tainter D, Gage M. Return to driving after fracture an overview of current recommendations. Current Orthopaedic Practice. 2020 Jan 1;31(4):408–11.
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  - VanDusen KW, Eleswarpu S, Moretti EW, Devinney MJ, Crabtree DM, Laskowitz DT, et al. The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction. J Alzheimers Dis. 2020;75(4):1319–28.
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  - Mundy LR, Klassen A, Grier J, Carty MJ, Pusic AL, Hollenbeck ST, et al. Development of a Patient-Reported Outcome Instrument for Patients With Severe Lower Extremity Trauma (LIMB-Q): Protocol for a Multiphase Mixed Methods Study. Jmir Res Protoc. 2019 Oct 17;8(10):e14397.
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  - Mundy LR, Grier AJ, Weissler EH, Carty MJ, Pusic AL, Hollenbeck ST, et al. Patient-reported Outcome Instruments in Lower Extremity Trauma: A Systematic Review of the Literature. Plast Reconstr Surg Glob Open. 2019 May;7(5):e2218.
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  - Berger M, Oyeyemi D, Olurinde MO, Whitson HE, Weinhold KJ, Woldorff MG, et al. The INTUIT Study: Investigating Neuroinflammation Underlying Postoperative Cognitive Dysfunction. J Am Geriatr Soc. 2019 Apr;67(4):794–8.
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  - Mascarenhas D, Connelly D, O’Hara NN, Gage MJ, Coale M, Manson TT, et al. Radiographic predictors of symptomatic locking screw removal after treatment of tibial fractures with intramedullary nails. Injury. 2018 Dec;49(12):2284–9.
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  - Shammas RL, Mundy LR, Truong T, Weber JM, Grier AJ, Cho EH, et al. Identifying Predictors of Time to Soft-Tissue Reconstruction following Open Tibia Fractures. Plast Reconstr Surg. 2018 Dec;142(6):1620–8.
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  - Gage MJ, Twomey KD, Sala DA, Maguire KJ, Hanstein R, Hennrikus WL, et al. Identifying Predictive Factors of Pediatric Septic Arthritis of the Knee in a Lyme Endemic Area. Bull Hosp Jt Dis (2013). 2018 Sep;76(3):161–4.
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  - Maceroli MA, Gage MJ, Wise BT, Connelly D, Ordonio K, Castillo RC, et al. Risk Factors for Failure of Bone Grafting of Tibia Nonunions and Segmental Bone Defects: A New Preoperative Risk Assessment Score. J Orthop Trauma. 2017 Oct;31 Suppl 5:S55–9.
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  - Mundy LR, Truong T, Shammas RL, Gage MJ, Pomann G-M, Hollenbeck ST. Acute Treatment Patterns for Lower Extremity Trauma in the United States: Flaps versus Amputation. J Reconstr Microsurg. 2017 Oct;33(8):563–70.
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  - Konda SR, Fisher N, Gage M, Egol KA. Posterior Fracture Dislocation of the Shoulder: A Modified McLaughlin Procedure. J Orthop Trauma. 2017 Aug;31 Suppl 3:S36–7.
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  - Konda SR, Gage M, Fisher N, Egol KA. Segmental Bone Defect Treated With the Induced Membrane Technique. J Orthop Trauma. 2017 Aug;31 Suppl 3:S21–2.
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  - Yoon RS, Gage MJ, Galos DK, Donegan DJ, Liporace FA. Trochanteric entry femoral nails yield better femoral version and lower revision rates-A large cohort multivariate regression analysis. Injury. 2017 Jun;48(6):1165–9.
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  - Gage MJ, Park BK, Strauss EJ. Reduction of anterior glenohumeral dislocations: a new closed reduction technique. Phys Sportsmed. 2017 Feb;45(1):22–5.
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  - Mundy LR, Gage MJ, Yoon RS, Liporace FA. Comparing the speed of irrigation between pulsatile lavage versus gravity irrigation: an Ex-vivo experimental investigation. Patient Saf Surg. 2017;11:7.
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  - Gage MJ, Yoon RS, Gaines RJ, Dunbar RP, Egol KA, Liporace FA. Dead Space Management After Orthopaedic Trauma: Tips, Tricks, and Pitfalls. J Orthop Trauma. 2016 Feb;30(2):64–70.
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  - Yoon RS, Gage MJ, Donegan DJ, Liporace FA. Intramedullary Nailing and Adjunct Permanent Plate Fixation in Complex Tibia Fractures. J Orthop Trauma. 2015 Aug;29(8):e277–9.
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  - Gage MJ, Yoon RS, Egol KA, Liporace FA. Uses of negative pressure wound therapy in orthopedic trauma. Orthop Clin North Am. 2015 Apr;46(2):227–34.
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  - Blank AT, Gage M, Tejwani N, McLaurin T. Overlapping Dislocation of the Pubic Symphysis with an Open Reduction and Anterior and Posterior Pelvic Ring Fixation: A Case Report. Jbjs Case Connect. 2015 Jan 28;5(1):e6.
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  - Gage MJ, Schwarzkopf R, Abrouk M, Slover JD. Impact of metabolic syndrome on perioperative complication rates after total joint arthroplasty surgery. J Arthroplasty. 2014 Sep;29(9):1842–5.
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  - Koerner JD, Patel NM, Yoon RS, Gage MJ, Donegan DJ, Liporace FA. Femoral malrotation after intramedullary nailing in obese versus non-obese patients. Injury. 2014 Jul;45(7):1095–8.
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  - Gage MJ, Egol KA. Painful hardware. What to do? Current Orthopaedic Practice. 2014 Jan 1;25(3):198–202.
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  - Gage MJ, Patel AV, Koenig KL, Newman E. Non-vena cava venous leiomyosarcomas: a review of the literature. Ann Surg Oncol. 2012 Oct;19(11):3368–74.
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  - Takemoto RC, Gage M, Rybak L, Zimmerman I, Egol KA. Accuracy of detecting screw penetration of the radiocarpal joint following volar plating using plain radiographs versus computed tomography. Am J Orthop (Belle Mead Nj). 2012 Aug;41(8):358–61.
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  - Gage MJ, Newman E, Maldonado TS, Hajdu CH. Leiomyosarcoma of the splenic vein. J Vasc Surg. 2012 May;55(5):1485–7.
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  - Takemoto RC, Gage MJ, Rybak L, Walsh M, Egol KA. Articular cartilage skiving: the concept defined. J Hand Surg Eur Vol. 2011 Jun;36(5):364–9.
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  - Spitzer AB, Gage MJ, Looze CA, Walsh M, Zuckerman JD, Egol KA. Factors associated with successful performance in an orthopaedic surgery residency. J Bone Joint Surg Am. 2009 Nov;91(11):2750–5.
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  - Slobogean GP, Sprague S, Wells J, Bhandari M, D’Alleyrand J-C, Harris AD, et al. Effectiveness of Iodophor vs Chlorhexidine Solutions for Surgical Site Infections and Unplanned Reoperations for Patients Who Underwent Fracture Repair. Jama Network Open. 3(4):e202215–e202215.
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- Book Sections
  - Sardesai N, Gage M, Sciadini M. Calcaneus fracture: Extended lateral approach. In: Fractures of the Foot and Ankle: A Clinical Casebook. 2017. p. 77–90.
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- Conference Papers
  - Klaucke J, O’Hara NN, Peterson D, Gitajn IL, Natoli R, Sciadini MF, et al. Quantitative Lesser Trochanter Profile Versus Cortical Step Sign in Assessing Femoral Malrotation After Femoral Nailing. In: J Orthop Trauma. 2020. p. e256–60.
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  - Wise BT, Connelly D, Rocca M, Mascarenhas D, Huang Y, Maceroli MA, et al. A Predictive Score for Determining Risk of Surgical Site Infection After Orthopaedic Trauma Surgery. In: J Orthop Trauma. 2019. p. 506–13.
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  - Mundy LR, Gage MJ, Hollenbeck ST. Predictors of Amputation Rates in Open Tibia Fractures. In: Journal of the American College of Surgeons. Elsevier BV; 2016. p. S85–S85.
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  - Gage MJ, Driesman A, Egol KA. Can We Better Monitor Hip Fracture Recovery? Advanced Tracking Devices in the Early Postoperative Period. In.
  - Gage MJ, Schwarzkopf R, Slover J. Impact of Obesity and Metabolic Syndrome on Peri-Operative Complication Rates After Total Joint Replacement Surgery. In.
  - Gage MJ, Schwarzkopf R, Slover J. Impact of Metabolic Syndrome on Peri-Operative Complication Rates after Total Joint Arthroplasty. In.
  - Gage MJ, Takemoto RC, Walsh M, Rybak L, Egol KA. Articular Skiving: A New Concept Defined. In.
  - Gage MJ, Yoon RS, Davidovitch R, Tejwani NC, Egol KA, Liporace FA, et al. Management of Osseous Defects in Orthopaedic Trauma. In.
  - Gage MJ, Yoon RS, Donegan DJ, Liporace FA. Negative Pressure Wound Boot Following Fixation of Pilon, Talus, and Calcaneus Fractures: A Pilot Study. In.
  - Gage MJ, Yoon RS, Liporace FA, Egol KA, Davidovitch R, Tejwani NC, et al. Soft Tissue Principles for Orthopaedic Trauma. In.
  - Gage MJ, Yoon RS, Liporace FA. Tips, Tricks and Pearls in the Treatment of Proximal Third Tibia Fractures with Intramedullary Nails. In.
  - Ganta A, Gage MJ, Roach R, Behery O, Leucht P, Konda A, et al. Complex Extremity Reconstruction in the Setting of Infection: What are our Antibiotic Delivery Options? In.
  - Ganta A, Yoon RS, Gage MJ, Liporace FA, Konda S, Egol KA. Intramedullary Nailing of Subtrochanteric Femur Fractures; What to Do, What Not to Do, and How to be Efficient. In.
  - Seigerman D, Yoon RS, Gage MJ, Koerner J, Patel NM, Donegan DJ, et al. Impact of Surrounding Canal Size on Time to Union Following Femoral Intramedullary Nailing: Does Size Really Matter? In.
  - Takemoto RC, Gage MJ, Egol KA. Accuracy Of Detecting Screw Penetration Of The Radiocarpal Joint Following Volar Plating Utilization Plain Radiographs vs. Computed Tomography. In.
  - Yoon RS, Gage MJ, Collinge CA, Haidukewych GJ, Liporace FA. Interprosthetic, Peri-implant and Periprosthetic Fractures in the Hip and Knee: Principles of Fixation. In.
  - Yoon RS, Gage MJ, Davidovitch R, Tejwani NC, Liporace FA, Egol KA. Tibial Plateau Fracture Evaluation Management and Outcomes. In.
  - Yoon RS, Gage MJ, Galos DK, Donegan DJ, Liporace FA. Trochanteric Entry Femoral Nails Yield Better Femoral Version and Lower Revision Rates. In.
  - Yoon RS, Gage MJ, Galos DK, Donegan DJ, Liporace FA. Trochanteric Entry Femoral Nails Yield Better Post-Operative Femoral Version and Lower Revision Rates Than Retrograde and Piriformis Entry Nails A Large Cohort Multivariate Regression Analysis. In.

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Education, Training, & Certifications

Previous Appointments & Affiliations

Awards & Honors

Subject Headings

Global Scholarship

Research

Teaching

Selected Grants

Fellowships, Supported Research, & Other Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Conference Papers