Mark Gage
Assistant Professor of Orthopaedic Surgery
I am an orthopaedic surgeon here at Duke specializing in the care of orthopaedic trauma, complex fractures, limb reconstruction, shoulder arthroplasty, osteomyelitis, and post-traumatic pathology including limb deformity, fracture non-union, and arthritis.
Current Research Interests
- Patient activity and bone healing
- Clinical outcomes after extremity trauma and orthopaedic intervention
- Osteomyelitis treatment strategies
- Postoperative pain control after orthopaedic surgery - exploring non-narcotic treatment options
- The effects of orthopaedic surgery and extremity implants on bone remodeling
- Orthopaedic fracture fixation strategies and their influence on bone healing/remodeling
Current Appointments & Affiliations
- Assistant Professor of Orthopaedic Surgery, Orthopaedics, Orthopaedics 2017
Contact Information
- 311 Trent Drive, Durham, NC 27710
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mark.gage@duke.edu
(919) 668-0291
- Background
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Education, Training, & Certifications
- Fellowship: Traumatology and Reconstructive Surgery, Orthopaedic Surgery, University of Maryland School of Medicine 2016 - 2017
- Residency, Orthopaedic Surgery, NYU Langone Orthopedic Hospital 2011 - 2016
- M.D., New York University School of Medicine 2011
- Recognition
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Awards & Honors
- Clifford H. Turen, MD Memorial Teacher of the Year Award. R Adams Cowley Shock Trauma Center, University of Maryland Medical Center. 2017
- Ralph Lusskin Outstanding Senior Resident Teaching Award. NYU Hospital for Joint Diseases. 2016
- Gold Humanism Honor Society. Gold Foundation. 2015
- Resident Scholarship. Foundation for Orthopaedic Trauma. 2015
- Expertise
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Subject Headings
- Analgesia
- Analgesia, Patient-Controlled
- Bone Remodeling
- Effect of implants on
- External skeletal fixation (Surgery)
- Fracture Fixation
- Fracture Healing
- Fracture fixation--Complications
- Infection
- Internal fixation in fractures
- Intramedullary fracture fixation
- Orthopedic implants industry
- Osteomyelitis
- Outcome assessment (Medical care)
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Global Scholarship
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Research
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Teaching
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- Research
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Selected Grants
- Safety, Efficacy, & Use of Vivigen Cellular Bone Matrix Allograft in Orthopaedic Fracture Care awarded by LifeNet Health 2020 - 2024
- PREPARE: A Pragmatic Randomized trial Evaluating Pre-operative Alcohol skin solutions in FRactured Extremities awarded by University of Maryland 2018 - 2021
- Postoperative Morbidity and Mortality for Hip Fracture Patient's with Chronic Liver Disease awarded by Piedmont Orthopedic Foundation 2019 - 2020
- Fresh Tissue Lab Agreement awarded by IlluminOss Medical, Inc. 2020
- Development of a Patient-Reported Outcome Instrument for Severe Lower Extremity Trauma: Cognitive Debriefing Interviews awarded by Foundation for Orthopedic Trauma 2018 - 2020
- Fresh Tissue Lab Agreement awarded by Tornier, Inc. 2018
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Fellowships, Supported Research, & Other Grants
- Kathy Cramer Young Clinician Memorial Scholarship awarded by Orthopaedic Trauma Association 2017
- Development of a PRO Instrument for Use in Severe Lower Extremity Trauma awarded by Duke Surgical Center for Outcomes Research Grant 2017 - 2018
- Identifying predictors for long-term success or failure of pilon fractures after surgical fixation awarded by AO Trauma North America Fellows Grant 2016
- Can We Better Monitor Hip Fracture Recovery? Advanced Tracking Devices in the Early Postoperative Period awarded by Orthopaedic Research and Education Foundation Resident Grant 2015
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External Relationships
- Arthrex, Inc.
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Mundy LR, Klassen A, Sergesketter AR, Grier AJ, Carty MJ, Hollenbeck ST, et al. Content Validity of the LIMB-Q: A Patient-Reported Outcome Instrument for Lower Extremity Trauma Patients. J Reconstr Microsurg. 2020 Nov;36(9):625–33.Full Text Link to Item
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Cunningham D, LaRose M, Gage M. The impact of substance use and abuse on opioid demand in lower extremity fracture surgery. Journal of Orthopaedic Trauma. 2020 Sep 3;Full Text
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Ryan SP, Padilla JA, Schwarzkopf R, Gage MJ, Bolognesi MP, Seyler TM. Arthroplasty Surgeons Do Not Improve Acute Outcomes for Patients With Hip Fracture Relative to Other Subspecialists. Orthopedics. 2020 Sep 1;43(5):e442–6.Full Text Link to Item
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Saltzman EB, Belay E, Federer AE, French R, Anakwenze O, Gage MJ, et al. Intramedullary Humeral Nail Placement through the Rotator Interval: An Anatomic and Radiographic Analysis. J Shoulder Elbow Surg. 2020 Aug 19;Full Text Link to Item
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Cunningham D, LaRose M, Klifto C, Gage M. Mental health and substance use impact perioperative opioid demand in upper extremity trauma surgery. J Shoulder Elbow Surg. 2020 Jul 7;Full Text Link to Item
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Ryan SP, Adams SB, Allen N, Lazarides A, Wellman SS, Gage MJ. Intraoperative Fire Risk: Evaluating The Three Minute Wait After Chlorhexidine-Alcohol Antiseptic Scrub. J Orthop Trauma. 2020 Jun 26;Full Text Link to Item
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Mundy LR, Klassen A, Grier AJ, Gibbons C, Lane W, Carty MJ, et al. Identifying Factors Most Important to Lower Extremity Trauma Patients: Key Concepts from the Development of a Patient-Reported Outcome Instrument for Lower Extremity Trauma, The LIMB-Q. Plast Reconstr Surg. 2020 May;145(5):1292–301.Full Text Link to Item
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Costales T, Shannon SF, Gage MJ, Manson TT. Current Treatments of Tibial Surgical Site Infection and Osteomyelitis after Fracture Surgery. Techniques in Orthopaedics. 2020 Jan 1;Full Text
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Danilkowicz R, Tainter D, Gage M. Return to driving after fracture an overview of current recommendations. Current Orthopaedic Practice. 2020 Jan 1;31(4):408–11.Full Text
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VanDusen KW, Eleswarpu S, Moretti EW, Devinney MJ, Crabtree DM, Laskowitz DT, et al. The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction. J Alzheimers Dis. 2020;75(4):1319–28.Full Text Open Access Copy Link to Item
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Mundy LR, Klassen A, Grier J, Carty MJ, Pusic AL, Hollenbeck ST, et al. Development of a Patient-Reported Outcome Instrument for Patients With Severe Lower Extremity Trauma (LIMB-Q): Protocol for a Multiphase Mixed Methods Study. Jmir Res Protoc. 2019 Oct 17;8(10):e14397.Full Text Link to Item
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Mundy LR, Grier AJ, Weissler EH, Carty MJ, Pusic AL, Hollenbeck ST, et al. Patient-reported Outcome Instruments in Lower Extremity Trauma: A Systematic Review of the Literature. Plast Reconstr Surg Glob Open. 2019 May;7(5):e2218.Full Text Link to Item
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Mascarenhas D, Connelly D, O’Hara NN, Gage MJ, Coale M, Manson TT, et al. Radiographic predictors of symptomatic locking screw removal after treatment of tibial fractures with intramedullary nails. Injury. 2018 Dec;49(12):2284–9.Full Text Link to Item
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Shammas RL, Mundy LR, Truong T, Weber JM, Grier AJ, Cho EH, et al. Identifying Predictors of Time to Soft-Tissue Reconstruction following Open Tibia Fractures. Plast Reconstr Surg. 2018 Dec;142(6):1620–8.Full Text Link to Item
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Gage MJ, Twomey KD, Sala DA, Maguire KJ, Hanstein R, Hennrikus WL, et al. Identifying Predictive Factors of Pediatric Septic Arthritis of the Knee in a Lyme Endemic Area. Bull Hosp Jt Dis (2013). 2018 Sep;76(3):161–4.Link to Item
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Maceroli MA, Gage MJ, Wise BT, Connelly D, Ordonio K, Castillo RC, et al. Risk Factors for Failure of Bone Grafting of Tibia Nonunions and Segmental Bone Defects: A New Preoperative Risk Assessment Score. J Orthop Trauma. 2017 Oct;31 Suppl 5:S55–9.Full Text Link to Item
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Mundy LR, Truong T, Shammas RL, Gage MJ, Pomann G-M, Hollenbeck ST. Acute Treatment Patterns for Lower Extremity Trauma in the United States: Flaps versus Amputation. J Reconstr Microsurg. 2017 Oct;33(8):563–70.Full Text Link to Item
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Konda SR, Fisher N, Gage M, Egol KA. Posterior Fracture Dislocation of the Shoulder: A Modified McLaughlin Procedure. J Orthop Trauma. 2017 Aug;31 Suppl 3:S36–7.Full Text Link to Item
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Konda SR, Gage M, Fisher N, Egol KA. Segmental Bone Defect Treated With the Induced Membrane Technique. J Orthop Trauma. 2017 Aug;31 Suppl 3:S21–2.Full Text Link to Item
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Yoon RS, Gage MJ, Galos DK, Donegan DJ, Liporace FA. Trochanteric entry femoral nails yield better femoral version and lower revision rates-A large cohort multivariate regression analysis. Injury. 2017 Jun;48(6):1165–9.Full Text Link to Item
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Gage MJ, Park BK, Strauss EJ. Reduction of anterior glenohumeral dislocations: a new closed reduction technique. Phys Sportsmed. 2017 Feb;45(1):22–5.Full Text Link to Item
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Mundy LR, Gage MJ, Yoon RS, Liporace FA. Comparing the speed of irrigation between pulsatile lavage versus gravity irrigation: an Ex-vivo experimental investigation. Patient Saf Surg. 2017;11:7.Full Text Open Access Copy Link to Item
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Gage MJ, Yoon RS, Gaines RJ, Dunbar RP, Egol KA, Liporace FA. Dead Space Management After Orthopaedic Trauma: Tips, Tricks, and Pitfalls. J Orthop Trauma. 2016 Feb;30(2):64–70.Full Text Link to Item
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Yoon RS, Gage MJ, Donegan DJ, Liporace FA. Intramedullary Nailing and Adjunct Permanent Plate Fixation in Complex Tibia Fractures. J Orthop Trauma. 2015 Aug;29(8):e277–9.Full Text Link to Item
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Gage MJ, Yoon RS, Egol KA, Liporace FA. Uses of negative pressure wound therapy in orthopedic trauma. Orthop Clin North Am. 2015 Apr;46(2):227–34.Full Text Link to Item
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Blank AT, Gage M, Tejwani N, McLaurin T. Overlapping Dislocation of the Pubic Symphysis with an Open Reduction and Anterior and Posterior Pelvic Ring Fixation: A Case Report. Jbjs Case Connect. 2015 Jan 28;5(1):e6–e6.Full Text Link to Item
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Gage MJ, Schwarzkopf R, Abrouk M, Slover JD. Impact of metabolic syndrome on perioperative complication rates after total joint arthroplasty surgery. J Arthroplasty. 2014 Sep;29(9):1842–5.Full Text Link to Item
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Koerner JD, Patel NM, Yoon RS, Gage MJ, Donegan DJ, Liporace FA. Femoral malrotation after intramedullary nailing in obese versus non-obese patients. Injury. 2014 Jul;45(7):1095–8.Full Text Open Access Copy Link to Item
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Gage MJ, Egol KA. Painful hardware. What to do? Current Orthopaedic Practice. 2014 Jan 1;25(3):198–202.Full Text
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Gage MJ, Patel AV, Koenig KL, Newman E. Non-vena cava venous leiomyosarcomas: a review of the literature. Ann Surg Oncol. 2012 Oct;19(11):3368–74.Full Text Link to Item
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Takemoto RC, Gage M, Rybak L, Zimmerman I, Egol KA. Accuracy of detecting screw penetration of the radiocarpal joint following volar plating using plain radiographs versus computed tomography. Am J Orthop (Belle Mead Nj). 2012 Aug;41(8):358–61.Link to Item
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Gage MJ, Newman E, Maldonado TS, Hajdu CH. Leiomyosarcoma of the splenic vein. J Vasc Surg. 2012 May;55(5):1485–7.Full Text Link to Item
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Takemoto RC, Gage MJ, Rybak L, Walsh M, Egol KA. Articular cartilage skiving: the concept defined. J Hand Surg Eur Vol. 2011 Jun;36(5):364–9.Full Text Link to Item
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Spitzer AB, Gage MJ, Looze CA, Walsh M, Zuckerman JD, Egol KA. Factors associated with successful performance in an orthopaedic surgery residency. J Bone Joint Surg Am. 2009 Nov;91(11):2750–5.Full Text Link to Item
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Book Sections
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Sardesai N, Gage M, Sciadini M. Calcaneus fracture: Extended lateral approach. In: Fractures of the Foot and Ankle: A Clinical Casebook. 2017. p. 77–90.Full Text
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Conference Papers
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Klaucke J, OʼHara NN, Peterson D, Gitajn IL, Natoli R, Sciadini MF, et al. Quantitative Lesser Trochanter Profile Versus Cortical Step Sign in Assessing Femoral Malrotation After Femoral Nailing. In: J Orthop Trauma. 2020. p. e256–60.Full Text Link to Item
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Wise BT, Connelly D, Rocca M, Mascarenhas D, Huang Y, Maceroli MA, et al. A Predictive Score for Determining Risk of Surgical Site Infection After Orthopaedic Trauma Surgery. In: J Orthop Trauma. 2019. p. 506–13.Full Text Link to Item
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Gage MJ, Liporace FA, Egol KA, McLaurin TM. Management of bone defects in orthopedic trauma. In: Bulletin of the Hospital for Joint Diseases. 2018. p. 4–8.
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Mundy LR, Gage MJ, Hollenbeck ST. Predictors of Amputation Rates in Open Tibia Fractures. In: Journal of the American College of Surgeons. Elsevier BV; 2016. p. S85–S85.Full Text
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Gage MJ, Driesman A, Egol KA. Can We Better Monitor Hip Fracture Recovery? Advanced Tracking Devices in the Early Postoperative Period. In.
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Gage MJ, Schwarzkopf R, Slover J. Impact of Obesity and Metabolic Syndrome on Peri-Operative Complication Rates After Total Joint Replacement Surgery. In.
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Gage MJ, Schwarzkopf R, Slover J. Impact of Metabolic Syndrome on Peri-Operative Complication Rates after Total Joint Arthroplasty. In.
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Gage MJ, Takemoto RC, Walsh M, Rybak L, Egol KA. Articular Skiving: A New Concept Defined. In.
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Gage MJ, Yoon RS, Donegan DJ, Liporace FA. Negative Pressure Wound Boot Following Fixation of Pilon, Talus, and Calcaneus Fractures: A Pilot Study. In.
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Gage MJ, Yoon RS, Liporace FA, Egol KA, Davidovitch R, Tejwani NC, et al. Soft Tissue Principles for Orthopaedic Trauma. In.
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Gage MJ, Yoon RS, Liporace FA. Tips, Tricks and Pearls in the Treatment of Proximal Third Tibia Fractures with Intramedullary Nails. In.
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Ganta A, Gage MJ, Roach R, Behery O, Leucht P, Konda A, et al. Complex Extremity Reconstruction in the Setting of Infection: What are our Antibiotic Delivery Options? In.
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Ganta A, Yoon RS, Gage MJ, Liporace FA, Konda S, Egol KA. Intramedullary Nailing of Subtrochanteric Femur Fractures; What to Do, What Not to Do, and How to be Efficient. In.
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Seigerman D, Yoon RS, Gage MJ, Koerner J, Patel NM, Donegan DJ, et al. Impact of Surrounding Canal Size on Time to Union Following Femoral Intramedullary Nailing: Does Size Really Matter? In.
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Takemoto RC, Gage MJ, Egol KA. Accuracy Of Detecting Screw Penetration Of The Radiocarpal Joint Following Volar Plating Utilization Plain Radiographs vs. Computed Tomography. In.
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Yoon RS, Gage MJ, Collinge CA, Haidukewych GJ, Liporace FA. Interprosthetic, Peri-implant and Periprosthetic Fractures in the Hip and Knee: Principles of Fixation. In.
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Yoon RS, Gage MJ, Davidovitch R, Tejwani NC, Liporace FA, Egol KA. Tibial Plateau Fracture Evaluation Management and Outcomes. In.
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Yoon RS, Gage MJ, Galos DK, Donegan DJ, Liporace FA. Trochanteric Entry Femoral Nails Yield Better Femoral Version and Lower Revision Rates. In.
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Yoon RS, Gage MJ, Galos DK, Donegan DJ, Liporace FA. Trochanteric Entry Femoral Nails Yield Better Post-Operative Femoral Version and Lower Revision Rates Than Retrograde and Piriformis Entry Nails A Large Cohort Multivariate Regression Analysis. In.
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