Mark Robert Spaller | Scholars@Duke

Mark Robert Spaller
Associate Professor of Chemistry at Duke Kunshan University

Current Appointments & Affiliations

Associate Professor of Chemistry at Duke Kunshan University, DKU Faculty, Duke Kunshan University 2020
Associate Professor of the Practice, DKU Visiting Faculty, Duke University 2020

Contact Information

mark.spaller@duke.edu

Background
Education, Training, & Certifications
- Ph.D., University of Texas, Austin 1995
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Patra, Chitta Ranjan, Chamila N. Rupasinghe, Shamit K. Dutta, Santanu Bhattacharya, Enfeng Wang, Mark R. Spaller, and Debabrata Mukhopadhyay. “Chemically-Modified Peptides Targeting the PDZ Domain of GIPC as a Therapeutic Approach for Cancer.” Acs Chemical Biology 14, no. 10 (October 2019): 2327. https://doi.org/10.1021/cb500865a.
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  - Pal, Krishnendu, Alexandre A. Pletnev, Shamit K. Dutta, Enfeng Wang, Ruizhi Zhao, Aradhita Baral, Vinod Kumar Yadav, et al. “Inhibition of endoglin-GIPC interaction inhibits pancreatic cancer cell growth.” Molecular Cancer Therapeutics 13, no. 10 (October 2014): 2264–75. https://doi.org/10.1158/1535-7163.mct-14-0291.
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  - Bhattacharya, Santanu, Krishnendu Pal, Anil K. Sharma, Shamit K. Dutta, Julie S. Lau, Irene K. Yan, Enfeng Wang, et al. “GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways.” Plos One 9, no. 12 (January 2014): e114409. https://doi.org/10.1371/journal.pone.0114409.
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  - Yedidi, Ravikiran S., Joseck M. Muhuhi, Zhigang Liu, Krisztina Z. Bencze, Kyriacos Koupparis, Carrie E. O’Connor, Iulia A. Kovari, Mark R. Spaller, and Ladislau C. Kovari. “Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease.” Biochemical and Biophysical Research Communications 438, no. 4 (September 2013): 703–8. https://doi.org/10.1016/j.bbrc.2013.07.117.
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  - Kaur, Moninderpal, Chamila N. Rupasinghe, Edvin Klosi, Mark R. Spaller, and Christine S. Chow. “Selection of heptapeptides that bind helix 69 of bacterial 23S ribosomal RNA.” Bioorganic & Medicinal Chemistry 21, no. 5 (March 2013): 1240–47. https://doi.org/10.1016/j.bmc.2012.12.048.
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  - Patra, Chitta Ranjan, Chamila N. Rupasinghe, Shamit K. Dutta, Santanu Bhattacharya, Enfeng Wang, Mark R. Spaller, and Debabrata Mukhopadhyay. “Chemically modified peptides targeting the PDZ domain of GIPC as a therapeutic approach for cancer.” Acs Chemical Biology 7, no. 4 (April 2012): 770–79. https://doi.org/10.1021/cb200536r.
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  - Wang, Ling, Julie S. Lau, Chitta Ranjan Patra, Ying Cao, Santanu Bhattacharya, Shamit Dutta, Debashis Nandy, et al. “RGS-GAIP-interacting protein controls breast cancer progression.” Molecular Cancer Research : Mcr 8, no. 12 (December 2010): 1591–1600. https://doi.org/10.1158/1541-7786.mcr-10-0209.
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  - Spaller, M. R. “Erratum: Act globally, think locally: Systems biology addresses the PDZ domain (ACS Chemical Biology (2006) 1 (207-210)).” Acs Chemical Biology 5, no. 7 (July 16, 2010): 713. https://doi.org/10.1021/cb100162s.
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  - Rubini, Chiara, Paolo Ruzza, Mark R. Spaller, Giuliano Siligardi, Rohanah Hussain, D Gomika Udugamasooriya, Massimo Bellanda, et al. “Recognition of lysine-rich peptide ligands by murine cortactin SH3 domain: CD, ITC, and NMR studies.” Biopolymers 94, no. 3 (January 2010): 298–306. https://doi.org/10.1002/bip.21350.
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  - Li, Mei, Anne-Cécile E. Duc, Edvin Klosi, Srividya Pattabiraman, Mark R. Spaller, and Christine S. Chow. “Selection of peptides that target the aminoacyl-tRNA site of bacterial 16S ribosomal RNA.” Biochemistry 48, no. 35 (September 2009): 8299–8311. https://doi.org/10.1021/bi900982t.
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  - Muders, Michael H., Pawan K. Vohra, Shamit K. Dutta, Enfeng Wang, Yasuhiro Ikeda, Ling Wang, D Gomika Udugamasooriya, et al. “Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth.” Clinical Cancer Research : An Official Journal of the American Association for Cancer Research 15, no. 12 (June 2009): 4095–4103. https://doi.org/10.1158/1078-0432.ccr-08-2837.
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  - Memic, Adnan, and Mark R. Spaller. “How do halogen substituents contribute to protein-binding interactions? A thermodynamic study of peptide ligands with diverse aryl halides.” Chembiochem : A European Journal of Chemical Biology 9, no. 17 (November 2008): 2793–95. https://doi.org/10.1002/cbic.200800572.
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  - Klosi, Edvin, Dorina Saro, and Mark R. Spaller. “Bivalent peptides as PDZ domain ligands.” Bioorganic & Medicinal Chemistry Letters 17, no. 22 (November 2007): 6147–50. https://doi.org/10.1016/j.bmcl.2007.09.035.
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  - Sharma, Sudhir C., Chamila N. Rupasinghe, Rachel B. Parisien, and Mark R. Spaller. “Design, synthesis, and evaluation of linear and cyclic peptide ligands for PDZ10 of the multi-PDZ domain protein MUPP1.” Biochemistry 46, no. 44 (November 2007): 12709–20. https://doi.org/10.1021/bi7008135.
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  - Saro, Dorina, Tao Li, Chamila Rupasinghe, Azrael Paredes, Nicole Caspers, and Mark R. Spaller. “A thermodynamic ligand binding study of the third PDZ domain (PDZ3) from the mammalian neuronal protein PSD-95.” Biochemistry 46, no. 21 (May 2007): 6340–52. https://doi.org/10.1021/bi062088k.
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  - Muders, M. H., G. B. Baretton, D. E. Aust, S. K. Dutta, E. Wang, Y. Ikeda, M. R. Spaller, K. Datta, and D. Mukhopadhyay. “[GIPC: a new target for therapy in pancreatic adenocarcinoma?].” Verh Dtsch Ges Pathol 91 (2007): 286–93.
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  - Muhuhi, Joseck, and Mark R. Spaller. “Expanding the synthetic method and structural diversity potential for the intramolecular Aza Diels-Alder cyclization.” The Journal of Organic Chemistry 71, no. 15 (July 2006): 5515–26. https://doi.org/10.1021/jo060148m.
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  - Cook, Jeremy D., Krisztina Z. Bencze, Ana D. Jankovic, Anna K. Crater, Courtney N. Busch, Patrick B. Bradley, Ann J. Stemmler, Mark R. Spaller, and Timothy L. Stemmler. “Monomeric yeast frataxin is an iron-binding protein.” Biochemistry 45, no. 25 (June 2006): 7767–77. https://doi.org/10.1021/bi060424r.
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  - Rupasinghe, Chamila N., and Mark R. Spaller. “The interplay between structure-based design and combinatorial chemistry.” Current Opinion in Chemical Biology 10, no. 3 (June 2006): 188–93. https://doi.org/10.1016/j.cbpa.2006.03.014.
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  - Spaller, Mark R. “Act globally, think locally: systems biology addresses the PDZ domain.” Acs Chemical Biology 1, no. 4 (May 2006): 207–10. https://doi.org/10.1021/cb600191y.
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  - Gerges, Nashaat Z., Donald S. Backos, Chamila N. Rupasinghe, Mark R. Spaller, and José A. Esteban. “Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane.” The Embo Journal 25, no. 8 (April 2006): 1623–34. https://doi.org/10.1038/sj.emboj.7601065.
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  - Udugamasooriya, Gomika, Dorina Saro, and Mark R. Spaller. “Bridged peptide macrocycles as ligands for PDZ domain proteins.” Organic Letters 7, no. 7 (March 2005): 1203–6. https://doi.org/10.1021/ol0475966.
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  - Saro, Dorina, Edvin Klosi, Azrael Paredes, and Mark R. Spaller. “Thermodynamic analysis of a hydrophobic binding site: probing the PDZ domain with nonproteinogenic peptide ligands.” Organic Letters 6, no. 20 (September 2004): 3429–32. https://doi.org/10.1021/ol049181q.
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  - Ukpabi, Nkoli, Sudhir Sharma, Mark R. Spaller, and Pearl Tsang. “(1)H, (15)N and (13)C backbone and side chain assignments of PSD-95 PDZ3 protein.” Journal of Biomolecular Nmr 30, no. 1 (September 2004): 111–12. https://doi.org/10.1023/b:jnmr.0000042953.83397.8e.
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  - Piserchio, Andrea, Gregory D. Salinas, Tao Li, John Marshall, Mark R. Spaller, and Dale F. Mierke. “Targeting specific PDZ domains of PSD-95; structural basis for enhanced affinity and enzymatic stability of a cyclic peptide.” Chemistry & Biology 11, no. 4 (April 2004): 469–73. https://doi.org/10.1016/j.chembiol.2004.03.013.
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  - Li, Tao, Dorina Saro, and Mark R. Spaller. “Thermodynamic profiling of conformationally constrained cyclic ligands for the PDZ domain.” Bioorganic & Medicinal Chemistry Letters 14, no. 6 (March 2004): 1385–88. https://doi.org/10.1016/j.bmcl.2003.09.103.
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  - Spaller, Mark R., Wolfgang T. Thielemann, Paul E. Brennan, and Paul A. Bartlett. “Combinatorial synthetic design. Solution and polymer-supported synthesis of heterocycles via intramolecular aza Diels-Alder and imino alcohol cyclizations.” Journal of Combinatorial Chemistry 4, no. 5 (September 2002): 516–22. https://doi.org/10.1021/cc020027+.
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  - Spaller, M. R., M. T. Burger, M. Fardis, and P. A. Bartlett. “Synthetic strategies in combinatorial chemistry.” Current Opinion in Chemical Biology 1, no. 1 (June 1997): 47–53. https://doi.org/10.1016/s1367-5931(97)80107-x.
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  - Martin, S. F., M. R. Spaller, and P. J. Hergenrother. “Expression and site-directed mutagenesis of the phosphatidylcholine-preferring phospholipase C of Bacillus cereus: probing the role of the active site Glu146.” Biochemistry 35, no. 39 (October 1996): 12970–77. https://doi.org/10.1021/bi961316f.
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  - Hergenrother, P. J., M. R. Spaller, M. K. Haas, and S. F. Martin. “Chromogenic assay for phospholipase C from Bacillus cereus.” Analytical Biochemistry 229, no. 2 (August 1995): 313–16. https://doi.org/10.1006/abio.1995.1418.
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  - Doyle, M. P., A. B. Dyatkin, A. V. Kalinin, D. A. Ruppar, S. F. Martin, M. R. Spaller, and S. Liras. “Highly Selective Enantiomer Differentiation in Intramolecular Cyclopropanation Reactions of Racemic Secondary Allylic Diazoacetates.” Journal of the American Chemical Society 117, no. 44 (January 1, 1995): 11021–22. https://doi.org/10.1021/ja00149a031.
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  - Martin, S. F., M. R. Spaller, S. Liras, and B. Hartmann. “Enantio- and Diastereoselectivity in the Intramolecular Cyclopropanation of Secondary Allylic Diazoacetates.” Journal of the American Chemical Society 116, no. 10 (May 1, 1994): 4493–94. https://doi.org/10.1021/ja00089a055.
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- Conference Papers
  - Gill, N. P., J. F. Amacher, L. J. Wallace, M. R. Spaller, and D. R. Madden. “ENGINEERING PEPTIDOMIMETIC THERAPEUTIC LEADS TO ENHANCE Delta F508 CFTR STABILITY AT THE APICAL MEMBRANE.” In Pediatric Pulmonology, 51:265–265. WILEY-BLACKWELL, 2016.
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  - Zhao, R., E. Klosi, A. Pletnev, C. Rupasinghe, and M. R. Spaller. “Towards Peptide Mimetics for PDZ Domains: From Binding Thermodynamics to Biological Probes.” In Biopolymers, 96:419–419. WILEY-BLACKWELL, 2011.
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  - Mukhopadhyay, D., M. H. Muders, and M. R. Spaller. “GAIP Interacting Protein C-Terminus (GIPC): A Novel Target for Pancreatic Adenocarcinoma Therapeutics.” In Pancreas, 38:1030–1030. LIPPINCOTT WILLIAMS & WILKINS, 2009.
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  - Mierke, D. F., A. Piserchio, J. Plati, C. Q. Sun, L. Wang, and M. R. Spaller. “Structure based rational design of inhibitors of PDZ-containing molecular scaffolds.” In Biopolymers, 80:591–591. JOHN WILEY & SONS INC, 2005.
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  - Udugamasooriya, G., D. Saro, and M. R. Spaller. “(Re)examining conformational constraint as a design strategy for protein-binding peptides.” In Biopolymers, 80:591–591. JOHN WILEY & SONS INC, 2005.
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  - Udugamasooriya, G., D. Saro, and M. R. Spaller. “(Re)examining conformational constraint as a design strategy for protein-binding peptides.” In Biopolymers, 80:536–37. JOHN WILEY & SONS INC, 2005.
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  - Kaplan, G. B., K. A. Leite-Morris, A. K. O’Neill, V. Kumaresan, M. R. Spaller, and J. Marshall. “Effects of treatment with a cyclic peptide that targets PDZ domain of PSD-95: Peptide administration to the ventral tegmental area inhibits opiate-induced motor sensitization in C57BL/6 mice.” In Neuropsychopharmacology, 29:S132–33. NATURE PUBLISHING GROUP, 2004.
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  - Saro, D., T. Li, E. Klosi, G. Udugamasooriya, C. Rupasinghe, and M. R. Spaller. “FROM COMBINATORIAL SYNTHESIS TO CELLULAR PROBES: DESIGNING CYCLIC AND MULTIVALENT PEPTIDE LIGANDS AS INHIBITORS OF SIGNAL TRANSDUCTION PROTEINS.” In Journal of Peptide Science, 10:115–115. JOHN WILEY & SONS LTD, 2004.
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  - Saro, D., T. Li, E. Klosi, G. Udugamasooriya, and M. R. Spaller. “Design and thermodynamic binding studies of cyclic and multivalent peptide ligands for the PDZ domain.” In Biopolymers, 71:413–413. JOHN WILEY & SONS INC, 2003.
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  - Saro, D., T. Li, E. Klosi, G. Udugamasooriya, and M. R. Spaller. “Design and thermodynamic binding studies of cyclic and multivalent peptide ligands for the PDZ domain.” In Biopolymers, 71:297–98. JOHN WILEY & SONS INC, 2003.
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  - Bartlett, P. A., M. A. Marx, A. L. Grillot, S. J. Gillett, M. R. Spaller, and E. D. Turtle. “Combinatorial synthetic design.” In Abstracts of Papers of the American Chemical Society, 213:59-CINF. AMER CHEMICAL SOC, 1997.
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  - Hergenrother, P. J., M. R. Spaller, and S. F. Martin. “Exploring the catalytic mechanism of phospholipase C.” In Abstracts of Papers of the American Chemical Society, 213:21-ORGN. AMER CHEMICAL SOC, 1997.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Selected Publications

Academic Articles

Conference Papers

Recent Courses