Jeffrey R. Marks

Journal article Nat Genet · June 2002 Featured Publication We found that PPM1D, encoding a serine/threonine protein phosphatase, lies within an epicenter of the region at 17q23 that is amplified in breast cancer. We show that overexpression of this gene confers two oncogenic phenotypes on cells in culture: attenua ... Full text Link to item Cite

Predicting the clinical status of human breast cancer by using gene expression profiles.

Journal article Proc Natl Acad Sci U S A · September 25, 2001 Featured Publication Prognostic and predictive factors are indispensable tools in the treatment of patients with neoplastic disease. For the most part, such factors rely on a few specific cell surface, histological, or gross pathologic features. Gene expression assays have the ... Full text Link to item Cite

Estrogen-induced mitogenesis of MCF-7 cells does not require the induction of mitogen-activated protein kinase activity.

Journal article J Steroid Biochem Mol Biol · December 1, 2000 Featured Publication Estrogen mediates the transcription of responsive genes via its interaction with the estrogen receptor (ER). This ligand-dependent transcriptional activity has been the mechanistic basis for understanding estrogen-induced proliferation. However, recent rep ... Full text Link to item Cite

Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.

Journal article Cell Growth Differ · February 2000 Featured Publication Estrogen acts to promote DNA synthesis in the MCF-7 human breast cancer cell line via its interaction with high levels of estrogen receptor. The primary mode of estrogen action has been considered to be through transcriptional activation of genes containin ... Link to item Cite

Isolation and initial characterization of the BRCA2 promoter.

Journal article Oncogene · October 28, 1999 Featured Publication The hereditary breast cancer susceptibility gene, BRCA2, is considered to be a tumor suppressor gene that may be involved in the cellular response to DNA damage. The transcript for this gene is cell cycle regulated with mRNA levels reaching a peak just bef ... Full text Link to item Cite

Frequency of germline and somatic BRCA1 mutations in ovarian cancer.

Journal article Clin Cancer Res · October 1998 Featured Publication Germline mutations in the BRCA1 tumor suppressor gene are thought to be the most common cause of hereditary ovarian cancer. The aim of this study was to explore further the role of BRCA1 alterations in the development of ovarian cancers. We sought to deter ... Link to item Cite

Predicting response to adjuvant and radiation therapy in patients with early stage breast carcinoma.

Journal article Cancer · March 1, 1998 Featured Publication BACKGROUND: Screening and surveillance is increasing the detection of early stage breast carcinoma. The ability to predict accurately the response to adjuvant therapy (chemotherapy or tamoxifen therapy) or postlumpectomy radiation therapy in these patients ... Full text Link to item Cite

BRCA1 expression is not directly responsive to estrogen.

Journal article Oncogene · January 9, 1997 Featured Publication Expression of the breast cancer susceptibility gene, BRCA1, is induced by 17-beta estradiol (E2) in estrogen receptor containing breast cancer cell lines. Our previous studies have shown that BRCA1 transcription is also regulated with the cell cycle, reach ... Full text Link to item Cite

BRCA1 expression is induced before DNA synthesis in both normal and tumor-derived breast cells.

Journal article Cell Growth Differ · June 1996 Featured Publication Insight into the function of the BRCA1 tumor suppressor gene may be gained by studying its regulation. In this study, the expression of BRCA1 was examined as a function of the cell cycle in normal and tumor-derived breast epithelial cells. Cells arrested i ... Link to item Cite

Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.

Journal article Cell Growth Differ · December 1994 Featured Publication Transforming growth factor beta (TGF beta) is an important regulator of cellular proliferation. In normal ovarian epithelial cells, TGF beta acts to inhibit growth. However, in ovarian cancer cell lines, this effect is usually lost. Although the regulatory ... Link to item Cite

Immune response to p53 is dependent upon p53/HSP70 complexes in breast cancers.

Journal article Proc Natl Acad Sci U S A · April 15, 1992 Featured Publication Overexpression of the p53 protein, resulting from gene mutations that increase protein stability, has been detected in greater than 25% of primary human breast cancers. In addition, approximately 10% of breast cancer patients have circulating antibodies to ... Full text Link to item Cite