Journal articleScience advances · December 2024
Carbon-based black pigments, a widely used class of pigments, are difficult to differentiate with the noninvasive techniques currently used in cultural heritage science. We use pump-probe microscopy, coupled with a support vector machine, to distinguish co ...
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Journal articleHardwareX · September 2024
In optical experiments, shutters are devices that open or close a path of light. They are often used to limit the duration of light exposure onto a target or onto a detector to reduce possible light-induced damage. Many commercial shutters are available fo ...
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Journal articleJphys Photonics · April 1, 2024
Cadmium sulfide (CdS) pigments have degraded in several well-known artworks, but the influence of pigment properties and environmental conditions on the degradation process have yet to be fully understood. Traditional non-destructive analysis techniques pr ...
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Journal articleOpt Express · August 29, 2022
Pump-probe microscopy of melanin in tumors has been proposed to improve diagnosis of malignant melanoma, based on the hypothesis that aggressive cancers disaggregate melanin structure. However, measured signals of melanin are complex superpositions of mult ...
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Journal articleInorganic chemistry · August 2021
Quaternary chalcogenide materials have long been a source of semiconductors for optoelectronic applications. Recent studies on I2-II-IV-X4 (I = Ag, Cu, Li; II = Ba, Sr, Eu, Pb; IV = Si, Ge, Sn; X = S, Se) materials have shown particul ...
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Journal articleOptics letters · March 2021
Pump-probe microscopy is an emerging nonlinear imaging technique based on high repetition rate lasers and fast intensity modulation. Here, we present new methods for pump-probe microscopy that keep the beam intensity constant and instead modulate the inter ...
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Journal articleSci Adv · September 2020
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Mandates for mask use in public during the recent coronavirus disease 2019 (COVID-19) pandemic, worsened by global shortage of commercial supplies, have led to widespread use of homemade masks and mask alternatives. It is assumed that wearing such masks re ...
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Journal articleOptics Express · April 13, 2020
We present a new imaging method for pump-probe microscopy that explores non-collinear excitation. This method (crossed-beam pump-probe microscopy, or CBPM) can significantly improve the axial resolution when imaging through low-NA lenses, providing ...
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Journal articleThe Journal of Chemical Physics · December 21, 2019
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The spatial heterogeneity of carrier dynamics in mixed halide perovskite CH3NH3PbI3−xClx thin films with a range of different chloride additions is mapped using femtosecond transient absorption microscopy (TAM). The comparison of TAM images of fibr ...
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Journal articleAdvanced Optical Materials · November 2019
AbstractThe spatial heterogeneity of carrier dynamics in polycrystalline metal halide perovskite (MHP) thin films has a strong influence on photovoltaic device performance; however, the underlying cause is not yet clearly u ...
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Journal articleScience Advances · June 2019
Pump-probe microscopy identifies metacinnabar and metallic mercury as possible degradation product of vermilion (α-HgS). ...
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Journal articleJ Low Genit Tract Dis · April 2017
OBJECTIVES: Melanomas of the female genital tract present a unique clinical challenge. Not only are these lesions in an anatomically sensitive area, but also they tend to be multifocal and have high recurrence rates. Furthermore, several benign melanocytic ...
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Journal articleReview of Scientific Instruments · March 1, 2016
Multiphoton microscopy has rapidly gained popularity in biomedical imaging and materials science because of its ability to provide three-dimensional images at high spatial and temporal resolution even in optically scattering environments. Currently ...
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Journal articleBiomed Opt Express · September 1, 2015
Metastatic melanoma is associated with a poor prognosis, but no method reliably predicts which melanomas of a given stage will ultimately metastasize and which will not. While sentinel lymph node biopsy (SLNB) has emerged as the most powerful predictor of ...
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Journal articleReview of Scientific Instruments · March 1, 2015
The lock-in amplifier is a critical component in many different types of experiments, because of its ability to reduce spurious or environmental noise components by restricting detection to a single frequency and phase. One example application is p ...
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Journal articleProceedings of the National Academy of Sciences · February 4, 2014
SignificanceWe show that a nonlinear microscopy technique (femtosecond pump-probe microscopy) allows for nondestructive 3D imaging of paintings with molecular and structural contrast. Until now, studying ...
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Journal articleJournal of Applied Physiology · March 2008
Early changes of lung function and structure were studied in the presence of an elastase-induced model of emphysema in 35 Sprague-Dawley rats at mild (5 U/100 g) and moderate (10 U/100 g) severities. Lung ventilation was measured on a regional basi ...
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Journal articleLaser Focus World · June 1, 2007
Femtosecond laser pulse and pulse-train shaping allow detection of new nonlinear effects, with modest powers, making new biomarkers accessible and permitting deeper tissue imaging than conventional microscopy. The most developed of these technique create l ...
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Journal articleMagn Reson Med · June 2005
In this experiment, Sprague-Dawley rats with elastase-induced emphysema were imaged using hyperpolarized (3)He MRI. Regional fractional ventilation r, the fraction of gas replaced with a single tidal breath, was calculated from a series of images in a wash ...
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Journal articleRadiol Clin North Am · January 2005
Recent advances in HP MR imaging contrast agents have led to novel tests of pulmonary function. Many of these tests show promise in the clinical arena. ...
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Journal articleMagn Reson Med · October 2004
Magnetic resonance imaging (MRI) with hyperpolarized 3-helium gas (HP 3He) offers the possibility of studying functional lung parameters such as the alveolar oxygen concentration and oxygen depletion rate. Until now, a double-acquisition technique has been ...
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Journal articleAcad Radiol · October 2004
RATIONALE AND OBJECTIVES: The aim of this study was to establish a standardized procedure for the measurement of regional fractional ventilation in a healthy rat model as a baseline for further studies of pulmonary disorder models. MATERIALS AND METHODS: T ...
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