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Martin Paul Tornai

Adjunct Associate Professor in the Department of Radiology
Radiology
Box 3949 Med Ctr, Durham, NC 27710
Circuit Drive, Research Park Bldg, Rm 118, Durham, NC 27710

Selected Publications


Normalized Comparison of Cancer Detection Rates in Contemporary Breast Imaging Technologies Used in Dense-Breast Supplemental Screening

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2024 We present an objective analysis and comparison on a level technological playing field of Cancer Detection Rates (CDRs) by performing a meta-analysis from publications about dense breasts using FDA-approved imaging modalities available for supplemental bre ... Full text Cite

Performance comparison of a dedicated total breast PET system with a clinical whole-body PET system: a simulation study.

Journal Article Phys Med Biol · May 20, 2021 This paper presents a novel PET geometry for breast cancer imaging. The scanner consists of a 'stadium' (a rectangle with two semi-circles on opposite sides) shaped ring, along with anterior and posterior panels to provide high sensitivity and high spatial ... Full text Link to item Cite

High sensitivity dedicated dual-breast PET/MR imaging: concept and preliminary simulations

Journal Article Proceedings of SPIE · May 22, 2020 This paper presents a new high-sensitivity PET geometry for high fidelity MRI-compatible PET breast imaging which can scan both breasts simultaneously and have: high sensitivity and resolution; compatibility with MR-breast imaged volume; complete visualiza ... Full text Open Access Cite

High sensitivity dedicated dual-breast PET/MR imaging: Concept and preliminary simulations

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2020 This paper presents a new high-sensitivity PET geometry for high fidelity MRI-compatible PET breast imaging which can scan both breasts simultaneously and have: high sensitivity and resolution; compatibility with MR-breast imaged volume; complete visualiza ... Full text Cite

Special Section Guest Editorial: Advances in Breast Imaging

Journal Article Journal of Medical Imaging · July 1, 2019 Full text Cite

Phantom Evaluation of a Multi-Pinhole Cardiac SPECT Camera for 3D Molecular Breast Imaging

Conference 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings · November 12, 2018 A tomographic clinical cardiac SPECT system consisting of many static CZT-based pinhole gamma cameras is evaluated for dedicated, pendant 3D molecular breast imaging. The reconstructed spatial resolution and linearity of the spherically symmetric FOV were ... Full text Cite

Characterization of CT Hounsfield Units for 3D acquisition trajectories on a dedicated breast CT system.

Journal Article J Xray Sci Technol · 2018 Hounsfield Units (HU) are used clinically in differentiating tissue types in a reconstructed CT image, and therefore the HU accuracy of a system is important, especially when using multiple sources, novel detector and non-traditional trajectories. Dedicate ... Full text Link to item Cite

Implementation and CT sampling characterization of a third-generation SPECT-CT system for dedicated breast imaging.

Journal Article J Med Imaging (Bellingham) · July 2017 Stand-alone cone beam computed tomography (CT) and single-photon emission computed tomography (SPECT) systems capable of complex acquisition trajectories have previously been developed for breast imaging. Fully three-dimensional (3-D) motions of SPECT syst ... Full text Link to item Cite

Characterization of X-ray scattering for various phantoms and clinical breast geometries using breast CT on a dedicated hybrid system.

Journal Article J Xray Sci Technol · 2017 OBJECTIVE: The purpose of this study was to utilize a dedicated breast CT system using a 2D beam stop array to physically evaluate the scatter to primary ratios (SPRs) of different geometric phantoms and prospectively acquired clinical patient data. METHOD ... Full text Link to item Cite

Implementation and first results of the fully suspended cone beam CT and SPECT system for dedicated breast imaging

Conference 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015 · October 3, 2016 Stand-alone cone beam CT and SPECT systems capable of complex sinusoidal acquisition trajectories have previously been developed for dedicated breast imaging and used in early clinical studies. The fully-3D motions of the SPECT system can view into the che ... Full text Cite

Development of fully-3D CT in a hybrid SPECT-CT breast imaging system

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2016 This work describes initial measurements with the CT subsystem of the assembled, fully-3D, hybrid SPECT-CT system for dedicated breast imaging. The hybrid system, designed for clinical breast imaging, consists of fully-flexible SPECT and CT subsystems, wit ... Full text Cite

Three dimensional dose distribution comparison of simple and complex acquisition trajectories in dedicated breast CT.

Journal Article Med Phys · August 2015 PURPOSE: A novel breast CT system capable of arbitrary 3D trajectories has been developed to address cone beam sampling insufficiency as well as to image further into the patient's chest wall. The purpose of this study was to characterize any trajectory-re ... Full text Link to item Cite

Characterization of simulated incident scatter and the impact on quantification in dedicated breast single-photon emission computed tomography.

Journal Article J Med Imaging (Bellingham) · July 2015 The objective was to characterize the changes seen from incident Monte Carlo-based scatter distributions in dedicated three-dimensional (3-D) breast single-photon emission computed tomography, with emphasis on the impact of scatter correction using the dua ... Full text Link to item Cite

Initial evaluation of a modified dual-energy window scatter correction method for CZT-based gamma cameras for breast SPECT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2015 Solid state Cadmium Zinc Telluride (CZT) gamma cameras for SPECT imaging offer significantly improved energy resolution compared to traditional scintillation detectors. However, the photopeak resolution is often asymmetric due to incomplete charge collecti ... Full text Cite

Three dimensional dose distribution comparison of simple and complex acquisition trajectories in dedicated breast CT using radiochromic film

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2015 A novel breast CT system capable of traversing non-traditional 3D trajectories was developed to address cone beam sampling insufficiency for pendant breast imaging. The purpose of this study was to characterize differences in three dimensional x-ray dose d ... Full text Cite

Coded aperture x-ray scatter tomography

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2014 We present a system for X-ray tomography using a coded aperture. A fan beam illuminates a 2D cross-section of an object and our coded aperture system produces a tomographic image from each static snapshot; as such, we can reconstruct either a static object ... Full text Cite

MTF characterization in 2D and 3D for a high resolution, large field of view flat panel imager for cone beam CT

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 The 2D and 3D modulation transfer functions (MTFs) of a custom made, large 40x30cm2 area, 600- micron CsI-TFT based flat panel imager having 127-micron pixellation, along with the micro-fiber scintillator structure, were characterized in detail using vario ... Full text Cite

Comparison of the effect of simple and complex acquisition trajectories on the 2D SPR and 3D voxelized differences for dedicated breast CT imaging

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 The 2D scatter-to-primary (SPR) ratios and 3D voxelized difference volumes were characterized for a cone beam breast CT scanner capable of arbitrary (non-traditional) 3D trajectories. The CT system uses a 30x30cm2 flat panel imager with 197 micron pixellat ... Full text Cite

Normalized Comparison of Cancer Detection Rates in Contemporary Breast Imaging Technologies Used in Dense-Breast Supplemental Screening

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2024 We present an objective analysis and comparison on a level technological playing field of Cancer Detection Rates (CDRs) by performing a meta-analysis from publications about dense breasts using FDA-approved imaging modalities available for supplemental bre ... Full text Cite

Performance comparison of a dedicated total breast PET system with a clinical whole-body PET system: a simulation study.

Journal Article Phys Med Biol · May 20, 2021 This paper presents a novel PET geometry for breast cancer imaging. The scanner consists of a 'stadium' (a rectangle with two semi-circles on opposite sides) shaped ring, along with anterior and posterior panels to provide high sensitivity and high spatial ... Full text Link to item Cite

High sensitivity dedicated dual-breast PET/MR imaging: concept and preliminary simulations

Journal Article Proceedings of SPIE · May 22, 2020 This paper presents a new high-sensitivity PET geometry for high fidelity MRI-compatible PET breast imaging which can scan both breasts simultaneously and have: high sensitivity and resolution; compatibility with MR-breast imaged volume; complete visualiza ... Full text Open Access Cite

High sensitivity dedicated dual-breast PET/MR imaging: Concept and preliminary simulations

Conference Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2020 This paper presents a new high-sensitivity PET geometry for high fidelity MRI-compatible PET breast imaging which can scan both breasts simultaneously and have: high sensitivity and resolution; compatibility with MR-breast imaged volume; complete visualiza ... Full text Cite

Special Section Guest Editorial: Advances in Breast Imaging

Journal Article Journal of Medical Imaging · July 1, 2019 Full text Cite

Phantom Evaluation of a Multi-Pinhole Cardiac SPECT Camera for 3D Molecular Breast Imaging

Conference 2017 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2017 - Conference Proceedings · November 12, 2018 A tomographic clinical cardiac SPECT system consisting of many static CZT-based pinhole gamma cameras is evaluated for dedicated, pendant 3D molecular breast imaging. The reconstructed spatial resolution and linearity of the spherically symmetric FOV were ... Full text Cite

Characterization of CT Hounsfield Units for 3D acquisition trajectories on a dedicated breast CT system.

Journal Article J Xray Sci Technol · 2018 Hounsfield Units (HU) are used clinically in differentiating tissue types in a reconstructed CT image, and therefore the HU accuracy of a system is important, especially when using multiple sources, novel detector and non-traditional trajectories. Dedicate ... Full text Link to item Cite

Implementation and CT sampling characterization of a third-generation SPECT-CT system for dedicated breast imaging.

Journal Article J Med Imaging (Bellingham) · July 2017 Stand-alone cone beam computed tomography (CT) and single-photon emission computed tomography (SPECT) systems capable of complex acquisition trajectories have previously been developed for breast imaging. Fully three-dimensional (3-D) motions of SPECT syst ... Full text Link to item Cite

Characterization of X-ray scattering for various phantoms and clinical breast geometries using breast CT on a dedicated hybrid system.

Journal Article J Xray Sci Technol · 2017 OBJECTIVE: The purpose of this study was to utilize a dedicated breast CT system using a 2D beam stop array to physically evaluate the scatter to primary ratios (SPRs) of different geometric phantoms and prospectively acquired clinical patient data. METHOD ... Full text Link to item Cite

Implementation and first results of the fully suspended cone beam CT and SPECT system for dedicated breast imaging

Conference 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015 · October 3, 2016 Stand-alone cone beam CT and SPECT systems capable of complex sinusoidal acquisition trajectories have previously been developed for dedicated breast imaging and used in early clinical studies. The fully-3D motions of the SPECT system can view into the che ... Full text Cite

Development of fully-3D CT in a hybrid SPECT-CT breast imaging system

Conference Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2016 This work describes initial measurements with the CT subsystem of the assembled, fully-3D, hybrid SPECT-CT system for dedicated breast imaging. The hybrid system, designed for clinical breast imaging, consists of fully-flexible SPECT and CT subsystems, wit ... Full text Cite

Three dimensional dose distribution comparison of simple and complex acquisition trajectories in dedicated breast CT.

Journal Article Med Phys · August 2015 PURPOSE: A novel breast CT system capable of arbitrary 3D trajectories has been developed to address cone beam sampling insufficiency as well as to image further into the patient's chest wall. The purpose of this study was to characterize any trajectory-re ... Full text Link to item Cite

Characterization of simulated incident scatter and the impact on quantification in dedicated breast single-photon emission computed tomography.

Journal Article J Med Imaging (Bellingham) · July 2015 The objective was to characterize the changes seen from incident Monte Carlo-based scatter distributions in dedicated three-dimensional (3-D) breast single-photon emission computed tomography, with emphasis on the impact of scatter correction using the dua ... Full text Link to item Cite

Initial evaluation of a modified dual-energy window scatter correction method for CZT-based gamma cameras for breast SPECT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2015 Solid state Cadmium Zinc Telluride (CZT) gamma cameras for SPECT imaging offer significantly improved energy resolution compared to traditional scintillation detectors. However, the photopeak resolution is often asymmetric due to incomplete charge collecti ... Full text Cite

Three dimensional dose distribution comparison of simple and complex acquisition trajectories in dedicated breast CT using radiochromic film

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2015 A novel breast CT system capable of traversing non-traditional 3D trajectories was developed to address cone beam sampling insufficiency for pendant breast imaging. The purpose of this study was to characterize differences in three dimensional x-ray dose d ... Full text Cite

Coded aperture x-ray scatter tomography

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · January 1, 2014 We present a system for X-ray tomography using a coded aperture. A fan beam illuminates a 2D cross-section of an object and our coded aperture system produces a tomographic image from each static snapshot; as such, we can reconstruct either a static object ... Full text Cite

MTF characterization in 2D and 3D for a high resolution, large field of view flat panel imager for cone beam CT

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 The 2D and 3D modulation transfer functions (MTFs) of a custom made, large 40x30cm2 area, 600- micron CsI-TFT based flat panel imager having 127-micron pixellation, along with the micro-fiber scintillator structure, were characterized in detail using vario ... Full text Cite

Comparison of the effect of simple and complex acquisition trajectories on the 2D SPR and 3D voxelized differences for dedicated breast CT imaging

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 The 2D scatter-to-primary (SPR) ratios and 3D voxelized difference volumes were characterized for a cone beam breast CT scanner capable of arbitrary (non-traditional) 3D trajectories. The CT system uses a 30x30cm2 flat panel imager with 197 micron pixellat ... Full text Cite

Design of a nested SPECT-CT system with fully suspended CT sub-system for dedicated breast imaging

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2014 A fully suspended, stand-Alone cone beam CT system capable of complex trajectories, in addition to a simple circular trajectory, has previously been developed and shown to minimize cone beam sampling insufficiencies and have better sampling close to the ch ... Full text Cite

Analysis of dependence of detector position on detected scatter distribution in dedicated breast SPECT

Journal Article Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2014 In SPECT, scattered photons contribute to the detected signal, reducing contrast and quantification accuracy. Several methods exist to correct scatter, including the dual-energy window technique, but have not been fully evaluated on non-traditional SPECT t ... Full text Cite

Three dimensional dose distribution comparison of simple and complex acquisition trajectories in dedicated breast CT - A Monte Carlo study

Journal Article Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · January 1, 2014 The purpose of this study was to characterize the three dimensional (3D) x-ray dose distributions in a target scanned with different acquisition trajectories for dedicated breast CT imaging. Monte Carlo simulations were used to evaluate two acquisition tra ... Full text Cite

Snapshot 2D tomography via coded aperture x-ray scatter imaging.

Journal Article Appl Opt · July 1, 2013 This paper describes a fan beam coded aperture x-ray scatter imaging system that acquires a tomographic image from each snapshot. This technique exploits the cylindrical symmetry of the scattering cross section to avoid the scanning motion typically requir ... Full text Link to item Cite

Quantification of Tc-99m sestamibi distribution in normal breast tissue using dedicated breast SPECT-CT

Journal Article Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · August 15, 2012 The use of Tc-99m-Sestamibi in molecular breast imaging is common due to its preferential uptake in malignant tissue. However, quantification of the baseline uptake in normal, healthy breast tissue is not possible using planar-imaging devices. Using our de ... Full text Cite

Development and initial demonstration of a low-dose dedicated fully 3D breast CT system

Journal Article Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · August 15, 2012 Based on earlier work demonstrating more complete, 3D cone beam sampling acquisition approaches that additionally facilitate chest wall imaging posterior to an uncompressed breast, a new, clinic-ready, low-dose breast CT system was developed and is undergo ... Full text Cite

Initial evaluation of a newly developed high resolution CT imager for dedicated breast CT

Journal Article Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) · August 15, 2012 A new, high resolution 40x30cm 2 area CsI-TFT based CT imager having 127μm pixel pitch was developed for fully-3D breast CT imaging as part of a SPECT-CT system. The imager has two narrow edges suited for pendant breast CT imaging close to the chest wall. ... Full text Cite

SU-E-I-02: Size-Dependent Computed Tomography Histogram Analysis: Towards Breast Tissue Segmentation.

Journal Article Med Phys · June 2012 PURPOSE: To examine the effects of object size on scatter-corrected CT histograms to be used in threshold-based tissue segmentation. METHODS: A polyethylene cone filled with various concentrations of water and methanol mixtures, simulating glandular and ad ... Full text Link to item Cite

SU-E-l-01: Investigating the Dependence of 2D and 3D Scatter-To-Primary Ratios on Breast Density in Clinical Breast CT.

Conference Med Phys · June 2012 PURPOSE: To characterize 2D and 3D scatter-to-primary ratios (SPR) and investigate the dependence of SPR on breast density based on clinicalpatient imaging on our dedicated SPECT-CT mammotomography system. METHODS: As a part of an on-going IRB approved pro ... Full text Link to item Cite

SU-E-I-11: A Novel High Resolution CT Imager for a Breast SPECT-CT System.

Conference Med Phys · June 2012 PURPOSE: To evaluate the intrinsic characteristics of a new high resolution, large area, small bezel, digital imager developed for a dedicated SPECT-CT system for fully-3D mammotomographic imaging applications. METHODS: A new flat panel digital imager was ... Full text Link to item Cite

SU‐E‐I‐12: Analysis of Image Noise in 3D Scatter Corrected Cone Beam CT Images as a Function of Object Size

Conference Medical Physics · January 1, 2012 Purpose: To characterize the spatial correlation of quantum noise of a cone beam CT (CBCT) system for breast imaging under scatter and non‐scatter corrected conditions as a function of object radius. Methods: Experiments were conducted using a conical phan ... Full text Cite

Initial In Vivo Quantification of Tc-99m Sestamibi Uptake as a Function of Tissue Type in Healthy Breasts Using Dedicated Breast SPECT-CT.

Journal Article J Oncol · 2012 A pilot study is underway to quantify in vivo the uptake and distribution of Tc-99m Sestamibi in subjects without previous history of breast cancer using a dedicated SPECT-CT breast imaging system. Subjects undergoing diagnostic parathyroid imaging studies ... Full text Open Access Link to item Cite

Towards Quantification of Functional Breast Images Using Dedicated SPECT With Non-Traditional Acquisition Trajectories.

Journal Article IEEE Trans Nucl Sci · October 2011 Quantification of radiotracer uptake in breast lesions can provide valuable information to physicians in deciding patient care or determining treatment efficacy. Physical processes (e.g., scatter, attenuation), detector/collimator characteristics, sampling ... Full text Link to item Cite

Evaluation of the absorbed dose to the breast using radiochromic film in a dedicated CT mammotomography system employing a quasi-monochromatic x-ray beam.

Journal Article Med Phys · June 2011 PURPOSE: A dual modality SPECT-CT prototype system dedicated to uncompressed breast imaging (mammotomography) has been developed. The computed tomography subsystem incorporates an ultrathick K-edge filtration technique producing a quasi-monochromatic x-ray ... Full text Link to item Cite

A high-performance SPECT-CT system for dedicated molecular breast imaging

Journal Article JOURNAL OF NUCLEAR MEDICINE · April 1, 2011 Link to item Cite

Characterization of Image Quality for 3D Scatter Corrected Breast CT Images.

Journal Article Proc SPIE Int Soc Opt Eng · March 16, 2011 The goal of this study was to characterize the image quality of our dedicated, quasi-monochromatic spectrum, cone beam breast imaging system under scatter corrected and non-scatter corrected conditions for a variety of breast compositions. CT projections w ... Full text Link to item Cite

Detailed Characterization of 2D and 3D Scatter-to-Primary Ratios of Various Breast Geometries Using a Dedicated CT Mammotomography System.

Journal Article Proc SPIE Int Soc Opt Eng · February 13, 2011 With a dedicated breast CT system using a quasi-monochromatic x-ray source and flat-panel digital detector, the 2D and 3D scatter to primary ratios (SPR) of various geometric phantoms having different densities were characterized in detail. Projections wer ... Full text Link to item Cite

Comparison of dual-window scatter correction and effective attenuation coefficients for quantification in dedicated breast SPECT

Journal Article IEEE Nuclear Science Symposium Conference Record · January 1, 2011 Correction for scattered and attenuated photons is necessary for accurate quantification in dedicated breast SPECT. An implemented dual energy window (DEW) scatter correction method along with attenuation correction has been shown to be accurate to within ... Full text Cite

Bienvenidos!

Journal Article IEEE Nuclear Science Symposium Conference Record · January 1, 2011 Full text Cite

Development of in vivo characterization of breast tissues through absolute attenuation coefficients using dedicated cone-beam CT

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · December 1, 2010 With advances in 3D in vivo imaging technology, non-invasive procedures can be used to characterize tissues to identify tumors and monitor changes over time. Using a dedicated breast CT system with a quasi-monochromatic cone-beam x-ray source and flat-pane ... Full text Cite

Characterizing the contribution of cardiac and hepatic uptake in dedicated breast SPECT using tilted trajectories.

Journal Article Phys Med Biol · August 21, 2010 A small field of view, high resolution gamma camera has been integrated into a dedicated breast, single photon emission computed tomography (SPECT) device. The detector can be flexibly positioned relative to the breast and image beyond the chest wall, allo ... Full text Link to item Cite

Observer detection limits for a dedicated SPECT breast imaging system.

Journal Article Phys Med Biol · April 7, 2010 An observer-based contrast-detail study is performed in an effort to evaluate the limits of object detectability using a dedicated CZT-based breast SPECT imaging system under various imaging conditions. A custom geometric contrast-resolution phantom was de ... Full text Link to item Cite

Is SPECT or CT Based Attenuation Correction More Quantitatively Accurate for Dedicated Breast SPECT Acquired with Non-Traditional Trajectories?

Journal Article IEEE Nucl Sci Symp Conf Rec (1997) · 2010 Attenuation correction is necessary for SPECT quantification. There are a variety of methods to create attenuation maps. For dedicated breast SPECT imaging, it is unclear if either SPECT- or CT-based attenuation map would provide the most accurate quantifi ... Full text Link to item Cite

Investigating the dose distribution in the uncompressed breast with a dedicated CT mammotomography system

Conference Progress in Biomedical Optics and Imaging - Proceedings of SPIE · January 1, 2010 A dual modality SPECT-CT prototype dedicated to uncompressed breast imaging (mammotomography) has been developed. The CT subsystem incorporates an ultra-thick K-edge filtration technique producing a quasi-monochromatic x-ray cone beam to optimize the dose ... Full text Cite

Towards quantification of dedicated breast SPECT using non-traditional acquisition trajectories

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2009 Quantification of radiotracer uptake in lesions can provide valuable information to physicians in deciding patient care or determining treatment efficacy. Physical processes (e.g. scatter, attenuation), detector/collimator characteristics, sampling and acq ... Full text Cite

Evaluation of tilted cone-beam CT orbits in the development of a dedicated hybrid mammotomograph.

Journal Article Phys Med Biol · June 21, 2009 A compact dedicated 3D breast SPECT-CT (mammotomography) system is currently under development. In its initial prototype, the cone-beam CT sub-system is restricted to a fixed-tilt circular rotation around the patient's pendant breast. This study evaluated ... Full text Link to item Cite

Initial investigation of novel trajectories to improve chest wall imaging in a dedicated breast computed tomography system

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 15, 2009 In current dedicated breast computed tomography (mammotomography) systems, comfortable patient positioning on a stationary bed restricts the practicable range of source-detector trajectories, thus compromising the system's ability to adequately image the p ... Full text Cite

Characterizing the MTF in 3D for a Quantized SPECT Camera Having Arbitrary Trajectories.

Journal Article IEEE Trans Nucl Sci · June 1, 2009 The emergence of application-specific 3D tomographic small animal and dedicated breast imaging systems has stimulated the development of simple methods to quantify the spatial resolution or Modulation Transfer Function (MTF) of the system in three dimensio ... Full text Link to item Cite

Novel Patient Optimized Acquisition Trajectories for Dedicated Breast SPECT Imaging

Conference 2008 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (2008 NSS/MIC), VOLS 1-9 · January 1, 2009 Link to item Cite

Comparison of 2D Scintimammography and 3D Dedicated Breast SPECT Using A Compressible Breast Phantom and Lesions of Varying Size and Tracer Uptake

Conference 2008 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (2008 NSS/MIC), VOLS 1-9 · January 1, 2009 Link to item Cite

Improved Chest Wall Imaging through Combined Complex Trajectories in Dedicated Dual Modality SPECT-CT Breast Molecular Imaging

Conference 2008 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (2008 NSS/MIC), VOLS 1-9 · January 1, 2009 Link to item Cite

Dynamic Laser-Guided Contouring for Dedicated Emission Mammotomography

Conference 2008 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (2008 NSS/MIC), VOLS 1-9 · January 1, 2009 Link to item Cite

Improved chest wall imaging through combined complex trajectories in dedicated dual modality SPECT-CT breast molecular imaging

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2008 In the hybrid SPECT-CT breast imaging system currently in development in our lab, patient positioning is a practical compromise between comfort and a need to maximize the imaged volume of breast and chest wall. The integrated imaging system rotates under t ... Full text Cite

Comparison of 2D scintimammography and 3D dedicated breast SPECT using a compressible breast phantom and lesions of varying size and tracer uptake

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2008 This study aims to qualitatively and quantitatively compare 2D planar scintimammography imaging of the breast under various degrees of compression with uncompressed, dedicated 3D SPECT using dedicated acquisition trajectories. A 700 m L compressible anthro ... Full text Cite

Novel patient optimized acquisition trajectories for dedicated breast SPECT imaging

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2008 Novel acquisition trajectories developed for our dedicated breast SPECT camera move 3 dimensionally within a hemispherical volume, fully contouring a patient's pendent breast to provide a high quality, high resolution 3D functional image. Each unique traje ... Full text Cite

Dynamic laser-guided contouring for dedicated emission mammotomography

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2008 The dedicated breast CZT-based SPECT imaging system in our lab implements novel 3D camera trajectories that can minimize breast-detector separation, thus improving resolution and image quality. Current trajectories are manually customized for each patient ... Full text Cite

TU‐C‐332‐04: Pilot Patient Studies Using a Dedicated Dual‐Modality SPECT‐CT System for Breast Imaging

Conference Medical Physics · January 1, 2008 Purpose: Acknowledging the limitations/discomfort of mammography has inspired the development of a dedicated SPECT‐CT system to detect breast cancer, monitor therapeutic responses, and improve patient comfort. This system provides semi‐quantitative 3D func ... Full text Cite

Comparison of reduced angle and fully 3D acquisition sequencing and trajectories for dual-modality mammotomography

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2007 A dual-modality SPECT-CT system for dedicated 3D breast cancer imaging is under development. Independent dedicated SPECT and CT imaging systems have been integrated onto a single gantry for uncompressed breast imaging. This study examines challenges and tr ... Full text Cite

Initial patient study with dedicated dual-modality SPECT-CT mammotomography

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2007 Dual-modality SPECT-CT dedicated breast imaging offers great promise in the detection/staging of cancer and the monitoring of treatment therapies. The sequential acquisition with emission (nuclear) and transmission (x-ray) 3D imaging systems can aid in loc ... Full text Cite

A contrast-detail comparison of computed mammotomography and digital mammography

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · October 16, 2007 We use a contrast-detail observer study to compare performance of a novel 3D computed mammotomography (CmT) system with a commercially developed full-field digital mammography (FFDM) system. A contrast-detail phantom comprised of uniform acrylic spheres of ... Full text Cite

Evaluation of lesion distortion at various CT system tilts in the development of a hybrid system for dedicated mammotomography

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · October 15, 2007 A hybrid SPECT-CT system for dedicated 3D breast imaging (mammotomography) is currently under development. Each imaging system will be placed on top of a single rotation stage and moved in unison azimuthally, with the SPECT system additionally capable of p ... Full text Cite

Investigating novel patient bed designs for use in a hybrid dual modality dedicated 3D breast imaging system

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · October 15, 2007 A hybrid SPECT-CT system for dedicated 3D breast cancer imaging (mammotomography) is in development. Using complex 3D imaging acquisition trajectories, the versatile integrated system will be capable of contouring and imaging an uncompressed breast suspend ... Full text Cite

Analysis of patient bed positioning in SPECT-CT imaging for dedicated mammotomography

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · October 15, 2007 Patient positioning on a bed is an integral part of accurate imaging for dedicated 3D breast imaging. For both dedicated breast SPECT (single photon emission computed tomography) and breast CT (computed tomography or computed mammotomography, CmT) which ar ... Full text Cite

Experimental spectral measurements of heavy K-edge filtered beams for x-ray computed mammotomography.

Journal Article Phys Med Biol · February 7, 2007 Featured Publication A dual modality computed mammotomography (CmT) and single photon emission computed tomography (SPECT) system for dedicated 3D breast imaging is in development. Using heavy K-edge filtration, the CmT component narrows the energy spectrum of the cone-shaped ... Full text Link to item Cite

WE‐D‐L100J‐08: Application of Volumetric Molecular Breast Imaging with a Dedicated SPECT‐CT Mammotomograph

Journal Article Medical Physics · January 1, 2007 Purpose: Clinical 2D‐scintimammography therapeutic response monitoring results imply that fully‐3D molecular imaging could benefit early response prediction. Capabilities of prototype functional SPECT and anatomical x‐ray CT integrated imaging subsystems, ... Full text Cite

Empirical effects of angular sampling and background content on image quality in dedicated breast SPECT

Journal Article IEEE Nuclear Science Symposium Conference Record · January 1, 2007 This study investigates the effects of varying the azimuthal and polar sampling of the acquisition trajectory with the dedicated breast SPECT imaging system developed in our lab. In addition, the frequency quality (density and distribution) of the backgrou ... Full text Cite

Performance of dedicated emission mammotomography for various breast shapes and sizes.

Journal Article Phys Med Biol · October 7, 2006 Featured Publication We evaluate the effect of breast shape and size and lesion location on a dedicated emission mammotomography system developed in our lab. The hemispherical positioning gantry allows ample flexibility in sampling a pendant, uncompressed breast. Realistic ant ... Full text Link to item Cite

A novel method to characterize the MTF in 3D for computed mammotomography

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 30, 2006 A novel phantom has been developed to measure the modulation transfer function (MTF) in 3D for x-ray computed tomography. The phantom consists of three tungsten wires, positioned nearly orthogonal to each other. Simultaneous measurements of the MTF are tak ... Full text Cite

Investigation of emission contamination in the transmission image of a dual modality computed mammotomography system

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 30, 2006 A dual modality SPECT/CT computed mammotomography (CmT) system for dedicated functional/structural breast imaging is under development. In simultaneous, dual-modality imaging, contamination of the transmission (x-ray) image by emission photons from the unc ... Full text Cite

Preliminary investigation of dose for a dedicated mammotomography system

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 30, 2006 We use a previously reported, optimized quasi-monochromatic beam technique together with unique complex acquisition trajectories made possible with a novel, dedicated cone-beam transmission computed mammotomography (CmT) system to investigate effects of lo ... Full text Cite

Experimental spectral measurements of heavy K-edge filtered beams for X-ray computed mammotomography

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 30, 2006 A compact, dual modality computed mammotomography (CmT) and single photon emission computed tomography (SPECT) system for dedicated 3D breast imaging is in development. The CmT component utilizes novel, heavy K-edge filtration to practicably narrow the ene ... Full text Cite

Initial comparison of registration and fusion of SPECT-CmT mammotomography images

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · June 22, 2006 A hybrid, dual modality single photon emission computed tomography (SPECT) and x-ray computed mammotomography (CmT) scanner for dedicated breast and axillary imaging is under development. CmT imaging provides high resolution anatomical images, whereas SPEC ... Full text Cite

Analysis of a novel offset cone-beam computed mammotomography system geometry for accomodating various breast sizes.

Journal Article Phys Med · 2006 We evaluate a newly developed dedicated cone-beam transmission computed mammotomography (CmT) system configuration using an optimized quasi-monochromatic cone beam technique for attenuation correction of SPECT in a planned dual-modality emission and transm ... Full text Link to item Cite

Initial development of a dual-modality SPECT-CT system for dedicated mammotomography

Journal Article IEEE Nuclear Science Symposium Conference Record · January 1, 2006 Dual-modality systems offer great promise in improving detection and evaluation of cancer through enhancement of the visual quality and quantitative accuracy of radionuclide imaging. A compact SPECT-CT system for dedicated 3D breast imaging is in developme ... Full text Cite

3-D Contrast-detail analysis for dedicated emission mammotomography

Journal Article IEEE Nuclear Science Symposium Conference Record · January 1, 2006 An observer based 3D contrast-detail study is performed in an effort to evaluate the limits of object detectability for a dedicated CZT-based SPECT mammotomography imaging system under various imaging conditions. A novel, geometric contrast-resolution phan ... Full text Cite

Physica Medica: Preface

Journal Article Physica Medica · January 1, 2006 Full text Cite

Patient Bed Design for an Integrated SPECT-CT Dedicated Mammotomography System

Conference 2006 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOL 1-6 · January 1, 2006 Link to item Cite

Characterizing the MTF in 3D for a quantized SPECT camera having arbitrary trajectories

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2005 The Modulation Transfer Function (MTF) in 3D is examined for a compact SPECT system capable of moving in different trajectories. A novel phantom has been developed to allow simultaneous measurements of the MTF oriented along three orthogonal axes for dedic ... Full text Cite

Towards patient imaging with dedicated emission mammotomography

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2005 A patient bed was recently developed and subsequent modifications made for 3D, pendant breast imaging with a dedicated emission mammotomography system that incorporates a discretized 16×20cm2 CZT gamma camera with 2.5mm pixels. Goals for these experiments ... Full text Cite

Investigating the effects of energy resolution in dedicated emission mammotomography

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2005 This study probes the recent debate over the necessity for good energy resolution for uncompressed breast, 3D lesion imaging with dedicated single photon emission mammotomography. Here, the imaging system consists of a commercial, discretized CZT gamma cam ... Full text Cite

Optimizing orientation of SPECT and cone beam CT detectors through quantification of cross contamination in a dual modality mammotomography system

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2005 A compact, dual modality SPECT/CT system for dedicated 3D breast imaging is in development. A major consideration in determining the relative placement of the SPECT and CT detectors is minimizing cross contamination. The transmission contamination of the e ... Full text Cite

Initial study of quasi-monochromatic x-ray beam performance for x-ray computed mammotomography

Journal Article IEEE Transactions on Nuclear Science · October 1, 2005 We evaluate the feasibility, benefits, and operating parameters of a quasimonochromatic beam for a newly developed x-ray cone beam computed mammotomography application. The value of a near monochromatic x-ray source for fully 3D dedicated mammotomography i ... Full text Cite

Comparison of compact gamma cameras with 1.3- And 2.0-mm quantized elements for dedicated emission mammotomography

Journal Article IEEE Transactions on Nuclear Science · October 1, 2005 In an effort to image smaller breast lesions, two compact gamma cameras with different intrinsic Nal(Tl) pixel sizes are evaluated for use in the application specific emission tomography (ASET) system for dedicated mammotomographic emission imaging. Compar ... Full text Cite

Anthropomorphic breast phantoms for preclinical evaluation with transmission or emission imaging

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · August 25, 2005 With the development of several classes of dedicated emission and transmission imaging technologies utilizing ionizing radiation for improved breast cancer detection and in vivo characterization, it is extremely useful to have available anthropomorphic bre ... Full text Cite

Design and development of a fully-3D dedicated x-ray computed mammotomography system

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · August 25, 2005 Our effort to implement a volumetric x-ray computed mammotomography (CmT) system dedicated to imaging breast disease comprises: demonstrated development of a quasi-monochromatic x-ray beam providing minimal dose and other optimal imaging figures of merit; ... Full text Cite

Investigation of cone-beam acquisitions implemented using a novel dedicated mammotomography system with unique arbitrary orbit capability

Journal Article Progress in Biomedical Optics and Imaging - Proceedings of SPIE · August 25, 2005 We investigate cone-beam acquisitions implemented on a novel dedicated cone-beam transmission computed mammotomography (CmT) system with unique arbitrary orbit capability for pendant, uncompressed breasts. We use a previously reported optimized quasi-monoc ... Full text Cite

Evaluation of fully 3-D emission mammotomography with a compact cadmium zinc telluride detector.

Journal Article IEEE Trans Med Imaging · July 2005 Featured Publication A compact, dedicated cadmium zinc telluride (CZT) gamma camera coupled with a fully three-dimensional (3-D) acquisition system may serve as a secondary diagnostic tool for volumetric molecular imaging of breast cancers, particularly in cases when mammograp ... Full text Link to item Cite

A framework for optimising the radiographic technique in digital X-ray imaging.

Journal Article Radiat Prot Dosimetry · 2005 Featured Publication The transition to digital radiology has provided new opportunities for improved image quality, made possible by the superior detective quantum efficiency and post-processing capabilities of new imaging systems, and advanced imaging applications, made possi ... Full text Link to item Cite

3D data acquisition sampling strategies for dedicated emission mammotomography for various breast sizes

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2004 The dedicated emission mammotomography system developed in our lab is in preparation for initial patient studies. As a preliminary step, we evaluate the effect of breast size and lesion location on this paradigm. The hemispherical positioning gantry allows ... Cite

Comparison of scintimammography and dedicated emission mammotomography

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2004 Using a 16 cm × 20 cm medium field of view CZT camera and a compressible breast phantom containing deformable lesions of various sizes and activity concentrations, a detailed comparison is made between 2D, planar scintimammography utilizing various degrees ... Cite

Intraoperative Probes and Imaging Probes

Chapter · November 18, 2004 This chapter provides an overview of counting and imaging probes, which are used to obtain count measurements and images during surgery. This chapter begins with the history of development of intraoperative probes. These have been employed to assist in the ... Full text Cite

Development of an optimal X-ray beam for dual-mode emission and transmission mammotomography

Journal Article Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment · July 11, 2004 The development of an optimal x-ray beam for dual-mode emission and transmission mammotomography for evaluation of breast lesions is discussed. The idealized operating parameters for the quasi-monochromatic beam were determined by evaluating a beam hardeni ... Full text Cite

Measurements of an optimized beam for x-ray computed mammotomography

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · July 5, 2004 Simulation results from previous studies indicate that a quasi-monochromatic x-ray beam can be produced using a newly developed beam filtration technique. This technique utilizes heavy filtration with novel high Z filter materials having k-edges just above ... Full text Cite

Simulation study of a quasi-monochromatic beam for x-ray computed mammotomography.

Journal Article Med Phys · April 2004 Featured Publication The purpose of this simulation study was to evaluate the feasibility, benefits, and potential operating parameters of a quasi-monochromatic beam from a tungsten-target x-ray source yielding projection images. The application is intended for newly developed ... Full text Link to item Cite

Feasibility of a beta-gamma digital imaging probe for radioguided surgery

Journal Article IEEE Transactions on Nuclear Science · February 1, 2004 We report here on a novel design of a digital, intraoperative imaging probe intended for use in radio-guided surgical procedures in conjunction with radiolabels such as 131I and 18F. The probe allows the user to rapidly localize tumors by detecting the hig ... Full text Cite

Initial study of quasi-monochromatic X-ray beam performance for X-ray computed mammotomography

Journal Article IEEE Nuclear Science Symposium Conference Record · December 1, 2003 We evaluate the feasibility, benefits, and operating parameters of a quasi-monochromatic beam for a newly developed X-ray cone beam computed mammotomography application. The value of a near monochromatic X-ray source for a fully 3D tomography application i ... Cite

Optimizing beam quality for X-ray computed mammotomography

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · September 15, 2003 The purpose of this study was to determine the optimum beam quality in terms of kVp and filtration for a tungsten-target x-ray source for a newly developed cone beam computed mammotomography application. The optimized beam is expected to yield enhanced ima ... Full text Cite

Mammotomography with pinhole incomplete circular orbit SPECT.

Journal Article J Nucl Med · April 2003 Featured Publication UNLABELLED: Dedicated mammotomography with pinhole incomplete circular orbit (PICO) SPECT imaging of an uncompressed pendant breast was evaluated with small, very-high-stopping-power pinhole apertures. Comparisons were made with planar pinhole scintimammog ... Link to item Cite

A 3D gantry single photon emission tomograph with hemispherical coverage for dedicated breast imaging

Journal Article Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment · January 21, 2003 A three-dimensional gantry single photon emission tomograph with hemispherical coverage for dedicated breast imaging was discussed. Projections with all photopeak window and camera tilt conditions were reconstructed with an ordered subsets expectation maxi ... Full text Cite

Detectors

Chapter · 2003 Diagnostic Nuclear Medicine, Fourth Edition. Edited by M.P. Sandler, R.E. Coleman, J. A. Patton. F.J.Th. Wackers, A. Gottschalk. Lippincott Williams & Wilkins, Philadelphia 2003. RENAL NUCLEAR MEDICINE BRUCE J. BARRON E . ... Cite

Implementation and Initial Characterization of Acquisition Orbits With a Dedicated Emission Mammotomograph

Journal Article IEEE Transactions on Nuclear Science · January 1, 2003 While contemporary clinical single photon emission computed tomography (SPECT) scanners are limited to a horizontal axis of rotation about the patient, the compact application specific emission tomography (ASET) system overcomes physical proximity limitati ... Full text Cite

Comparison of compact gamma cameras with 1.3mm and 2.0mm quantized elements for dedicated emission mammotomography

Journal Article IEEE Nuclear Science Symposium Conference Record · January 1, 2003 In an effort to image smaller breast lesions, two compact gamma cameras with different intrinsic NaI(TI) pixel sizes are evaluated for use in the Application Specific Emission Tomography system for mammotomographic emission imaging. Comparison measurements ... Full text Cite

Simulation study of quasi-monochromatic X-ray beam performance for X-ray computed mammotomography given various breast compositions and lesion sizes

Journal Article IEEE Nuclear Science Symposium Conference Record · January 1, 2003 A quasi-monochromatic X-ray computed mammo-tomograph (XCT) system is under development. The importance of a near-monochromatic x-ray beam is that tissues of close attenuation coefficients are expected to be more easily separable compared with those from a ... Full text Cite

Transmission Imaging with a Compact Gamma Camera: Initial Results for Mammotomography

Journal Article IEEE Nuclear Science Symposium and Medical Imaging Conference · December 1, 2002 A dedicated single photon emission prototype imaging system is intended for fully 3D Application Specific Emission and Transmission Tomography (ASETT), where one specific application is dedicated breast imaging. In breast imaging, this dual-modality system ... Cite

Initial Investigation of Circle-Plus-Arc Orbit Variants with a Dedicated Emission Mammotomograph

Journal Article IEEE Nuclear Science Symposium and Medical Imaging Conference · December 1, 2002 A dedicated emission mammotomograph, uniquely capable of imaging in a hemisphere, is utilized to image the breast by way of complex acquisition orbits, completely sampling most of the breast. Orbits such as the circle-plus-arc (CPA) in particular provide f ... Cite

Feasibility of a Beta-Gamma Digital Imaging Probe for Radioguided Surgery

Journal Article IEEE Nuclear Science Symposium and Medical Imaging Conference · December 1, 2002 We report here on a novel design of a digital, intraoperative imaging probe intended for use in radio-guided surgical procedures in conjunction with radiolabels such as 131I and 18F. The probe allows the user to rapidly localize tumors by detecting the hig ... Cite

A novel silicon array designed for intraoperative charged particle imaging.

Journal Article Med Phys · November 2002 Featured Publication A novel Si-PIN imaging array is under investigation for a charged particle (beta, positron, or alpha) sensitive intraoperative camera to be used for (residual) tumor identification during surgery. This class of collimator-less nuclear imaging device has a ... Full text Link to item Cite

Observer studies of cardiac lesion detectability with triple-head 360° vs. dual-head 180° SPECT acquisition using simulated projection data

Journal Article IEEE Nuclear Science Symposium and Medical Imaging Conference · August 31, 2002 The purpose of this study is to evaluate cardiac lesion detectability with triple-head 360-degree versus dual-head 180-degree myocardial perfusion SPECT scans with equal acquisition time. The channelized Hotelling observer (CHO) and human observers were us ... Cite

Observer studies of cardiac lesion detectability with triple-head 360° versus dual-head 180° SPECT acquisition using simulated projection data

Journal Article IEEE Transactions on Nuclear Science · June 1, 2002 The purpose of this study is to evaluate cardiac lesion detectability with triple-head 360° versus dual-head 180° myocardial perfusion SPECT scans with equal acquisition time. The channelized Hotelling observer (CHO) and human observers were used. A male a ... Full text Cite

Modeling the axial extension of a transmission line source within iterative reconstruction via multiple transmission sources.

Journal Article IEEE Trans Med Imaging · March 2002 Featured Publication Reconstruction algorithms for transmission tomography have generally assumed that the photons reaching a particular detector bin at a particular angle originate from a single point source. In this paper, we highlight several cases of extended transmission ... Full text Link to item Cite

SPECT breast imaging combining horizontal and vertical axes of rotation

Journal Article IEEE Transactions on Nuclear Science · February 1, 2002 Vertical-axis-of-rotation (VAOR) geometries, in which a gamma camera orbits a pendulous breast of a prone patient, have been proposed for SPECT breast imaging. Dedicated VAOR systems would be advantageous since they allow for minimal radius of rotation aro ... Full text Cite

Implementation and initial characterization of acquisition orbits about a pendulous breast using the ASET system

Journal Article IEEE Nuclear Science Symposium and Medical Imaging Conference · December 1, 2001 The goal of the Application Specific Emission Tomography (ASET) system is to image small (≤ 1 cm diameter) lesions and lesions of low activity uptake in a pendulous breast reference frame with high contrast and signal-to-noise ratio (SNR). While contempora ... Cite

SPECT breast imaging using more nearly complete orbits and combined pinhole-parallel-beam collimation

Journal Article IEEE Nuclear Science Symposium and Medical Imaging Conference · December 1, 2001 Two novel pinhole orbits for SPECT breast imaging are investigated using noise-free analytically simulated projection data. The two orbits are designed to more nearly completely sample the breast region while also maintaining close proximity of the pinhole ... Cite

A novel application specific emission tomograph (ASET) for breast imaging

Journal Article IEEE Nuclear Science Symposium and Medical Imaging Conference · December 1, 2001 A novel, dedicated and compact single photon ASET dedicated to pendant-breast nuclear medicine-based lesion imaging is developed. The prototype ASET system utilizes a compact gamma camera mounted on a support with variable radius-of-rotation, which is coup ... Cite

Breast tumor imaging using a tiltable head SPECT camera

Journal Article IEEE Transactions on Nuclear Science · August 1, 2001 As a test bed for dedicated breast single-photon emission computed tomography (SPECT) cameras that are under development, a general purpose SPECT system with two tiltable heads was used to image fillable breast and torso phantoms containing multiple lesion ... Full text Cite

Dedicated PICO-SPECT: An approach to clinical breast imaging.

Journal Article JOURNAL OF NUCLEAR MEDICINE · May 1, 2001 Link to item Cite

An EM algorithm for estimating SPECT emission and transmission parameters from emissions data only.

Journal Article IEEE Trans Med Imaging · March 2001 Featured Publication A maximum-likelihood (ML) expectation-maximization (EM) algorithm (called EM-IntraSPECT) is presented for simultaneously estimating single photon emission computed tomography (SPECT) emission and attenuation parameters from emission data alone. The algorit ... Full text Link to item Cite

Investigation of microcolumnar scintillators on an optical fiber coupled compact imaging system

Journal Article IEEE Transactions on Nuclear Science · January 1, 2001 A compact imaging system with a novel front-end detector is under investigation and development. Unique aspects of this collimatorless system include the use of thin arrays of many thousands of microcolumnar (<10 μm diameter) CsI front-end scintillators th ... Full text Cite

Physical phantom evaluation of EM-IntraSPECT (EMIS) algorithm for non-uniform attenuation correction in cardiac imaging

Journal Article Proceedings of SPIE-The International Society for Optical Engineering · January 1, 2001 The purpose of this study was to evaluate performance of the EM-IntraSPECT (EMIS) algorithm for non-uniform attenuation correction in the chest EMIS is a maximum-likelihood expectation maximization (MLEM) algorithm for simultaneously estimating SPECT emiss ... Full text Cite

Uranium pinhole collimators for 511-keV photon SPECT imaging of small volumes

Journal Article IEEE Trans. Nucl. Sci. (USA) · 2001 Depleted uranium (DU) pinhole collimators are evaluated for small-volume SPECT imaging of 511-keV gammas, with a view toward small-animal imaging. Tungsten (W) pinholes are examined for comparison. Line source measurements show planar full-width at half-ma ... Full text Link to item Cite

Parallel-beam tilted-head analytic SPECT reconstruction

Journal Article IEEE Nuclear Science Symposium and Medical Imaging Conference · January 1, 2001 Parallel-beam Tilted-Head SPECT (TH-SPECT) was previously implemented on a SPECT system for its potential to image breast lesions and nearby axilla of seated, upright women. All TH-SPECT reconstructions will contain artifacts since the tilted orbit does no ... Full text Cite

Breast tumor imaging using a tiltable head SPECT camera

Journal Article IEEE Nuclear Science Symposium and Medical Imaging Conference · December 1, 2000 An axially Tiltable-Head SPECT (TH-SPECT) system with 2 heads was used to image tillable breast and torso phantoms containing multiple lesions at various tilt angles. Breast, liver, and myocardial activity were included in order to simulate direct contamin ... Cite

SPECT breast imaging combining horizontal and vertical axes of rotation

Journal Article IEEE Nuclear Science Symposium and Medical Imaging Conference · December 1, 2000 Vertical axis of rotation (VAOR) geometries in which the patient lies prone with one pendulous breast, and a gamma camera orbits the breast have been proposed for SPECT breast imaging. Dedicated VAOR systems are advantageous for several reasons. They allow ... Cite

Effects of pinhole material and aperture size on lesion contrast and SNR in breast SPECT

Journal Article IEEE Nuclear Science Symposium and Medical Imaging Conference · December 1, 2000 Pinhole collimators made of depleted uranium-238 (DU) and tungsten alloy (VV) with aperture diameters from 1 - 4 mm were used to image <0.6 ml breast lesions in a pendulous breast reference frame, centered on the axis-of-rotation. with incomplete circular ... Cite

Investigation of micro-columnar scintillators on an optical fiber coupled compact imaging system

Journal Article IEEE Nuclear Science Symposium and Medical Imaging Conference · December 1, 2000 A compact imaging system with a novel front-end detector is under investigation and development. Unique aspects of this collimator-less system include the use of many thousands of micro-columnar (<10 μm diameter) CsI front-end scintillators (140 and 200 mi ... Cite

Fast-timing silicon photodetectors

Journal Article IEEE Transactions on Nuclear Science · June 2000 Full text Cite

Analytical versus voxelized phantom representation for Monte Carlo simulation in radiological imaging.

Journal Article IEEE Trans Med Imaging · May 2000 Featured Publication Monte Carlo simulations in nuclear medicine, with accurately modeled photon transport and high-quality random number generators, require precisely defined and often detailed phantoms as an important component in the simulation process. Contemporary simulat ... Full text Link to item Cite

Investigation of large fffild-of-vlew transmission imaging for spect attenuation compensation with GO-153, TC-99m and CE-139 sources

Journal Article IEEE Transactions on Nuclear Science · January 1, 2000 A recently developed, large field-of-view (FOV), dual head SPECT system was investigated for fast sequential fan-beam (FB) transmission computed tomography (TCT) with various transmission sources. For TCT, the system utilizes a fixed line source at the 77 ... Full text Cite

Intraoperative probes and imaging probes.

Journal Article Eur J Nucl Med · August 1999 Featured Publication Intraoperative probes have been employed to assist in the detection and removal of tumors for more than 50 years. For a period of about 40 years, essentially every detector type that could be miniaturized had been tested or at least suggested for use as an ... Full text Link to item Cite

Small-animal PET: advent of a new era of PET research.

Journal Article J Nucl Med · July 1999 Featured Publication Link to item Cite

Effect and correction of detector sag in SPECT systems.

Journal Article JOURNAL OF NUCLEAR MEDICINE · May 1, 1999 Link to item Cite

Ultra-high resolution SPECT images with uranium pinhole collimators.

Journal Article JOURNAL OF NUCLEAR MEDICINE · May 1, 1999 Link to item Cite

Evaluation of transmission source collimation for SPECT attenuation compensation

Conference 1999 IEEE NUCLEAR SCIENCE SYMPOSIUM - CONFERENCE RECORD, VOLS 1-3 · January 1, 1999 Link to item Cite

Uranium pinhole collimators for positron emission SPECT imaging of small volumes

Conference 1999 IEEE NUCLEAR SCIENCE SYMPOSIUM - CONFERENCE RECORD, VOLS 1-3 · January 1, 1999 Link to item Cite

A dual detector β-ray imaging probe with γ-ray background suppression for use in intra-operative detection of radiolabeled tumors

Journal Article Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment · May 21, 1998 The basic concepts for a dual detector β+ imaging probe incorporating a method of γ-ray background suppression were evaluated. The test devices consisted of a 1.2 cm2 β+ imaging CaF2(Eu) scintillator disk optically coupled to a 1.7 mm thick, area-matched t ... Full text Cite

High resolution CsI(Tl)/Si-PIN detector development for breast imaging

Journal Article IEEE Transactions on Nuclear Science · January 1, 1998 High resolution multi-element (8×8) imaging arrays with collimators, size matched to discrete CsI(Tl) sdntillator arrays and Si-PIN photodetector arrays (PDA's) were developed as prototypes for larger arrays for breast imaging. Photodetector pixels were ea ... Full text Cite

A miniature phoswich detector for gamma-ray localization and beta imaging

Journal Article IEEE Transactions on Nuclear Science · January 1, 1998 A combined y-ray probe/imaging detector was created by modification of a beta imaging intra-operative probe. This phoswich detector consists of a thin CaF2(Eu) 1 imaging disk, coupled through a light diffuser to 7 or 19 parallelepiped highZ scintillation c ... Full text Cite

Compton scatter and X-ray crosstalk and the use of very thin intercrystal septa in high-resolution PET detectors

Journal Article IEEE Transactions on Nuclear Science · December 1, 1997 To improve spatial resolution, positron emission tomography (PET) systems are being developed with finer detector elements. Unfortunately, using a smaller crystal size increases intercrystal Compton scatter and X-ray escape crosstalk, causing positioning e ... Full text Cite

Investigation of crystal geometries for fiber coupled gamma imaging intra-operative probes

Journal Article IEEE Transactions on Nuclear Science · December 1, 1997 CsI(Na), CsI(Tl) and Nal(Tl) scintillators coupled through optical fibers were investigated with simulations and measurements to evaluate their potential as gamma imaging intraoperative probes. Three coupling methods were employed: discrete crystals couple ... Full text Cite

Discrete scintillator coupled mercuric iodide photodetector arrays for breast imaging

Journal Article IEEE Transactions on Nuclear Science · December 1, 1997 Multi-element (4x4) imaging arrays with high resolution collimators, size matched to discrete CsI(Tl) scintillator arrays and mercuric iodide photodetector arrays (HgI2 PDA) were developed as prototypes for larger 16×16 element arrays for breast imaging. T ... Full text Cite

Development of an intraoperative gamma camera based on a 256-pixel mercuric iodide detector array

Journal Article IEEE Transactions on Nuclear Science · December 1, 1997 A 256-element mercuric iodide (HgI2) detector array has been developed which is intended for use as an intraoperative gamma camera (IOGC). The camera is specifically designed for use in imaging gamma-emitting radiopharmaceuticals (such as 99m-Tc labeled Se ... Full text Cite

Annihilation y ray background characterization and rejection for a small beta camera used for tumor localization during surgery

Journal Article IEEE Transactions on Nuclear Science · December 1, 1997 We have developed a miniature (1.2 cm2) beta-ray camera prototype to assist a surgeon in locating the margins of a resected tumor. With this technique, one directly detects betas emitted from exposed radio-labeled tissue. When imaging positron emitting rad ... Full text Cite

PSPMT and photodiode designs of a small scintillation camera for imaging malignant breast tumors

Journal Article IEEE Transactions on Nuclear Science · December 1, 1997 We are investigating the concept of utilizing a small gamma ray scintillation camera to help identify and localize malignant breast tumors after a suspicious finding in a mammogram. Excellent sensitivity and specificity for malignant breast tumors has been ... Full text Cite

Miniature phoswich detector for gamma-ray localization and beta imaging

Journal Article IEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1997 A combined γ-ray probe/γ+ imaging detector was created through the modification of a beta imaging intra-operative probe. The phoswich detector consists of a thin CaF2(Eu) β+ imaging disk, coupled through a light diffuser to 7 or 19 parallel-piped high-Z sc ... Cite

Gamma and beta intra-operative imaging probes

Journal Article Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment · June 21, 1997 Small area (∼1.5 cm2) scintillation cameras for imaging gammas and betas using inter-changeable detector front ends were built and characterized. Components common to both emission imaging cameras include: (1) fiber optic bundles 2-3 m long, comprised of m ... Full text Cite

Dedicated breast imaging system based on a novel solid state detector array

Journal Article JOURNAL OF NUCLEAR MEDICINE · May 1, 1997 Link to item Cite

Design and performance of gamma and beta intra-operative imaging probes

Journal Article Physica Medica · January 1, 1997 A prototype small area scintillation camera capable of imaging both gammas and betas by use of inter-changeable detector front ends was characterized. In the camera's application, patients are injected with tumor seeking radiopharmaceuticals before surgery ... Cite

Design and performance of gamma and beta intra-operative imaging probes

Journal Article Physica Medica · 1997 A prototype small area scintillation camera capable of imaging both gammas and betas by use of inter-changeable detector front ends was characterized. In the camera's application, patients are injected with tumor seeking radiopharmaceuticals before surgery ... Cite

Design considerations and initial performance of a 1.2 cm2 beta imaging intra-operative probe

Journal Article IEEE Transactions on Nuclear Science · December 1, 1996 A novel small area beta (β±) detector is under development for nuclear emission imaging of surgically exposed, radiolabeled tumor beds. The imaging device front-end consists of a 0.5 mm thick by 1.25 cm diameter CaF2(Eu) scintillator disk coupled to a rigi ... Full text Cite

Optimizing light collection from thin scintillators used in a beta-ray camera for surgical use

Journal Article IEEE Transactions on Nuclear Science · December 1, 1996 We are developing a 1-2 cm2 area camera for imaging the distribution of beta-emitting radiopharmaceuticals at the surface of tissue exposed during surgery. The front end consists of a very thin continuous or segmented scintillator sensitive to betas (posit ... Full text Cite

Investigation of crystal geometries for fiber coupled gamma imaging intra-operative probes

Journal Article IEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1996 In this work, gamma sensitive intra-operative imaging detectors using CsI(Na), CsI(Tl) and NaI(Tl) scintillators coupled through optical fibers were investigated with simulations and measurements. Three coupling methods were employed between the detectors ... Cite

PSPMT and PIN diode designs of a small scintillation camera for imaging malignant breast tumors

Journal Article IEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1996 We are investigating the concept of utilizing a small gamma ray scintillation camera to help identify and localize malignant breast tumors after a suspicious finding in a mammogram. We are exploring two different photodetector technologies for a small prot ... Cite

Annihilation gamma ray background characterization and rejection for a positron camera

Journal Article IEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1996 We have developed a miniature (1.2 cm2) beta-ray camera prototype to assist a surgeon in locating and removing the margins of a resected tumor. When imaging positron emitting radiopharmaceuticals, annihilation gamma ray interactions in the detector can mim ... Cite

Discrete scintillator coupled mercuric iodide photodetector arrays for breast imaging

Journal Article IEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1996 Multi-element (4×4) imaging arrays with high resolution collimators, size matched to discrete CsI(Tl) scintillator arrays and mercuric iodide photodetector arrays (HgI2 PDA) are under development as prototypes for larger 16×16 element arrays. The compact n ... Cite

Mercuric iodide photodetector arrays for gamma-ray imaging

Journal Article Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment · October 1, 1996 We have developed a novel detector device, namely: a mercuric iodide photodetector array (HgI2 PDA) to be used with a scintillating crystal for X-ray and gamma-ray imaging. A HgI2 PDA prototype with 16-pixels has been evaluated with segmented scintillators ... Full text Cite

Characterization of fluor concentration and geometry in organic scintillators for in situ beta imaging

Journal Article IEEE Transactions on Nuclear Science · January 1, 1996 Development of a small area (1-2 cm2 ) in situ beta imaging device includes optimization of the front end scintillation detector, which is fiber optically coupled to a remote photon detector. Thin plastic scintillation detectors, which are sensitive to cha ... Full text Cite

Design considerations and initial performance of a 1.2cm2 beta imaging intra-operative probe

Journal Article IEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1995 A novel small area beta detector is under development for nuclear emission imaging of surgically exposed radiolabeled tumor beds. The detector size (1.2 cm2) is determined by the requirement to introduce the probe into small cavities, e.g. during neuro-sur ... Cite

Optimizing light collection from thin scintillators used in a beta-ray camera for surgical use

Journal Article IEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1995 We are developing a 1-2 cm2 area camera for imaging the distribution of beta emitting radiopharmaceuticals at the surface of tissue exposed during surgery. The front end consists of a very thin continuous or segmented scintillator sensitive to betas (posit ... Cite

Characterization of flour concentration and geometry in organic scintillators for in situ beta imaging

Journal Article IEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1995 Development of a small area (1-2 cm2) in situ beta imaging device includes optimization of the front end scintillation detector which is fiber optically coupled to a remote photon detector. Thin plastic scintillation detectors, which are sensitive to charg ... Cite

Compton scatter and x-ray crosstalk and the use of very thin inter-crystal septa in high resolution PET detectors

Journal Article IEEE Nuclear Science Symposium & Medical Imaging Conference · December 1, 1995 To improve spatial resolution, PET systems are being developed with finer detector elements. Unfortunately, using smaller crystal sizes increases inter-crystal Compton scatter and bismuth x-ray and (to a lesser degree) electron escape crosstalk, causing po ... Cite

Development of a mercuric iodide detector array for medical imaging applications

Journal Article Nuclear Inst. and Methods in Physics Research, A · November 21, 1995 A nineteen element mercuric iodide (HgI2) detector array has been developed as a prototype for a larger (169 element) array, which is intended for use as an intra-operative gamma camera (IOGC). This work is motivated by the need for identifying and removin ... Full text Cite

A Comparison of PET Detector Modules Employing Rectangular and Round Photomultiplier Tubes

Journal Article IEEE Transactions on Nuclear Science · January 1, 1995 We have compared the high resolution BGO detector blocks from the EXACT HR PET system which use two dual-cathode rectangular photomultiplier (PM) tubes with a new block design, the EXACT HR PLUS, which uses four round PM tubes. Despite the lower coupling a ... Full text Cite

Collection of Scintillation Light from Small BGO Crystals

Journal Article IEEE Transactions on Nuclear Science · January 1, 1995 We propose to develop a high resolution positron emission tomography (PET) detector designed for animal imaging. The detector consists of a 2-D array of small bismuth germanate (BGO) crystals coupled via optical fibers to a multi-channel photomultiplier tu ... Full text Cite

Small-area fiber-coupled scintillation camera for imaging beta-ray distributions intraoperatively

Journal Article Proceedings of SPIE - The International Society for Optical Engineering · January 1, 1995 A small area, imaging, scintillation probe is being developed for locating small amounts of radio-labeled malignant tissue during surgery. Preliminary in brain surgery, avoiding the removal of excess tissue is a priority. It is possible to locate the main ... Full text Cite

Investigation of the Physical Aspects of Beta Imaging Probes Using Scintillating Fibers and Visible Light Photon Counters

Journal Article IEEE Transactions on Nuclear Science · January 1, 1995 We are developing a hand-held imaging probe intended for intra-operative use. This probe is to be used after the bulk of a tumor has been removed. It will locate residual malignant tissue labeled by a pre-operative injection of a tumor-seeking radiopharmac ... Full text Cite

Collection of scintillation light from small BGO crystals

Journal Article IEEE Transactions on Nuclear Science · 1995 We propose to develop a high resolution positron emission tomography (PET) detector designed for animal imaging. The detector consists of a 2-D array of small bismuth germanate (BGO) crystals coupled via optical fibers to a multi-channel photomultiplier tu ... Cite

Investigation of the physical aspects of beta imaging probes using scintillating fibers and visible light photon counters

Journal Article IEEE Nuclear Science Symposium & Medical Imaging Conference · January 1, 1995 We are developing a hand held imaging probe intended for intra-operative use. This probe is to be used after the bulk of tumor has been removed. It will locate residual malignant tissue labeled by a pre-operative injection of a tumor seeking radiopharmaceu ... Cite

Effect of refraction index and light sharing on detector element identification for 2D detector modules in Positron Emission Tomography

Journal Article Nuclear Inst. and Methods in Physics Research, A · September 1, 1994 Relationships among indices of refraction (n) of scintillation detectors, light sharing among discrete detector elements and accuracy of detector element identification in Positron Emission Tomography (PET) 2-D detector arrays were examined with theory and ... Full text Cite

Positioning And Energy Response Of Pet Block Detectors With Different Light Sharing Schemes

Journal Article IEEE Transactions on Nuclear Science · January 1, 1994 Two state-of-the-art modular PET block detectors using either discrete or pseudo-discrete BGO crystals coupled to two dual PMTs, utilizing different light sharing schemes, were evaluated. Both detectors were approximately 30 mm thick, while each element of ... Full text Cite

Positioning and energy response of PET block detectors with different light sharing schemes

Journal Article IEEE Nuclear Science Symposium & Medical Imaging Conference · January 1, 1994 Two state-of-the-art modular PET block detectors using either discrete or pseudo-discrete BGO crystals coupled to two dual PMTs, utilizing different light sharing schemes, were evaluated. Both detectors were approximately 30 mm thick, while each element of ... Cite

Detection and quantitation of 17F formation during the cyclotron production of 13N.

Journal Article Int J Rad Appl Instrum A · July 1992 The positron emitter 17F has been identified for the first time as a radioactive contaminant formed during 13N production. It was determined that 17F made up 18% of the short-lived radioactivity previously thought to be exclusively 15O. Mathematical deconv ... Full text Link to item Cite

Investigation of full-field CZT detector for emission mammotomography

Conference 2003 IEEE Nuclear Science Symposium. Conference Record (IEEE Cat. No.03CH37515) Full text Cite