Martin Howard Ulshen | Scholars@Duke

Martin Howard Ulshen
Professor Emeritus of Pediatrics

Clinical Trial-Crohn's Disease
Clinical Trial-Ulcerative colitis
Clinical Trial-Treatment of constipation in children

Current Appointments & Affiliations

Professor Emeritus of Pediatrics, Pediatrics, Gastroenterology, Hepatology and Nutrition, Pediatrics 2014

Contact Information

375 Hanes House, Box 102375, Durham, NC 27710
377 Hanes House, 330 Trent Drive, Durham, NC 27710
martin.ulshen@duke.edu (919) 684-5068

Background
Education, Training, & Certifications
- Fellow, Gastroenterology (Med) & Res. Fel. (Peds), Pediatrics, Children's Hospital Boston 1975 - 1977
- Fellow - Pediatric Gastroenterology, Pediatrics, University of Colorado, Colorado Springs 1974 - 1975
- Resident, Pediatrics, University of Colorado, Colorado Springs 1972 - 1974
- Intern, Medicine-Pediatrics, Medicine Pediatrics, North Carolina Memorial Hospital 1969 - 1970
- M.D., University of Rochester 1969
Duke Appointment History
- Professor of Pediatrics, Pediatrics, Gastroenterology, Hepatology and Nutrition, Pediatrics 2000 - 2014
- Chief, Division of Pediatric Gastroenterology, Hepatology & Nutrition, Pediatrics, Gastroenterology, Hepatology and Nutrition, Pediatrics 2004 - 2014
- Instructor, Temporary in the Department of Pediatrics, Pediatrics, Gastroenterology, Hepatology and Nutrition, Pediatrics 1999
Research
Selected Grants
- Biomarkers of Interoceptive Awareness in Adolescent Anorexia Nervosa awarded by National Institutes of Health 2009 - 2012
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Tilburg, Miranda A. L. van, Megan Squires, Nanette Blois-Martin, Cathy Williams, Marc A. Benninga, Babette Peeters, and Martin Ulshen. “Parental knowledge of fecal incontinence in children.” J Pediatr Gastroenterol Nutr 55, no. 3 (September 2012): 283–87. https://doi.org/10.1097/MPG.0b013e31824cf555.
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  - Greenberg, Rachel G., Cassandra Moran, Martin Ulshen, P Brian Smith, Daniel K. Benjamin, and Michael Cohen-Wolkowiez. “Outcomes of catheter-associated infections in pediatric patients with short bowel syndrome.” J Pediatr Gastroenterol Nutr 50, no. 4 (April 2010): 460–62. https://doi.org/10.1097/MPG.0b013e3181b99d07.
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  - Tilburg, Miranda A. L. van, Denesh K. Chitkara, Olafur S. Palsson, Marsha Turner, Nanette Blois-Martin, Martin Ulshen, and William E. Whitehead. “Audio-recorded guided imagery treatment reduces functional abdominal pain in children: a pilot study.” Pediatrics 124, no. 5 (November 2009): e890–97. https://doi.org/10.1542/peds.2009-0028.
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  - Tilburg, Miranda A. L. van, Neeta Venepalli, Martin Ulshen, Katherine L. Freeman, Rona Levy, and William E. Whitehead. “Parents' worries about recurrent abdominal pain in children.” Gastroenterol Nurs 29, no. 1 (January 2006): 50–55. https://doi.org/10.1097/00001610-200601000-00009.
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  - Kader, Howard A., Wallace F. Berman, Amal S. Al-Seraihy, Russell E. Ware, Martin H. Ulshen, and William R. Treem. “Prevalence of factor V G1691A (Leiden), prothrombin G20210A, and methylene tetrahydrofolate reductase C677T thrombophilic mutations in children with inflammatory bowel disease.” J Pediatr Gastroenterol Nutr 35, no. 5 (November 2002): 629–35. https://doi.org/10.1097/00005176-200211000-00008.
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  - Worawattanakul, M., J. M. Rhoads, S. N. Lichtman, and M. H. Ulshen. “Abdominal migraine: prophylactic treatment and follow-up.” J Pediatr Gastroenterol Nutr 28, no. 1 (January 1999): 37–40. https://doi.org/10.1097/00005176-199901000-00010.
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  - Rittmeyer, C., D. Nakayama, and M. H. Ulshen. “Lymphoid hyperplasia causing recurrent rectal prolapse.” J Pediatr 131, no. 3 (September 1997): 487–88. https://doi.org/10.1016/s0022-3476(97)80086-8.
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  - Ohneda, K., M. H. Ulshen, C. R. Fuller, A. J. D’Ercole, and P. K. Lund. “Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I.” Gastroenterology 112, no. 2 (February 1997): 444–54. https://doi.org/10.1053/gast.1997.v112.pm9024298.
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  - Sävendahl, L., L. E. Underwood, K. M. Haldeman, M. H. Ulshen, and P. K. Lund. “Fasting prevents experimental murine colitis produced by dextran sulfate sodium and decreases interleukin-1 beta and insulin-like growth factor I messenger ribonucleic acid.” Endocrinology 138, no. 2 (February 1997): 734–40. https://doi.org/10.1210/endo.138.2.4941.
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  - Ulshen, M. H., and R. H. Raasch. “Luminal epidermal growth factor preserves mucosal mass of small bowel in fasting rats.” Clin Sci (Lond) 90, no. 5 (May 1996): 427–31. https://doi.org/10.1042/cs0900427.
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  - Hoyt, E. C., P. K. Lund, D. E. Winesett, C. R. Fuller, M. A. Ghatei, S. R. Bloom, and M. H. Ulshen. “Effects of fasting, refeeding, and intraluminal triglyceride on proglucagon expression in jejunum and ileum.” Diabetes 45, no. 4 (April 1996): 434–39. https://doi.org/10.2337/diab.45.4.434.
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  - Ulshen, M. H., E. C. Hoyt, C. R. Fuller, M. A. Ghatei, S. R. Bloom, and P. K. Lund. “Increased ileal proglucagon expression after jejunectomy is not suppressed by inhibition of bowel growth.” Dig Dis Sci 41, no. 4 (April 1996): 677–83. https://doi.org/10.1007/BF02213122.
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  - Murray, S. C., R. S. Sandler, T. O. Keku, C. M. Lyles, R. C. Millikan, S. I. Bangdiwala, L. L. Kupper, W. Jiang, and M. H. Ulshen. “Comparison of rectal mucosal proliferation measured by proliferating cell nuclear antigen (PCNA) immunohistochemistry and whole crypt dissection.” Cancer Epidemiol Biomarkers Prev 4, no. 7 (October 1995): 715–20.
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  - Rhoads, J. M., M. H. Ulshen, E. O. Keku, W. Chen, H. M. Kandil, J. P. Woodard, S. C. Liu, C. R. Fuller, H. L. Leary, and J. G. Lecce. “Oral transforming growth factor-alpha enhances jejunal mucosal recovery and electrical resistance in piglet rotavirus enteritis.” Pediatr Res 38, no. 2 (August 1995): 173–81. https://doi.org/10.1203/00006450-199508000-00007.
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  - Winesett, D. E., M. H. Ulshen, E. C. Hoyt, N. K. Mohapatra, C. R. Fuller, and P. K. Lund. “Regulation and localization of the insulin-like growth factor system in small bowel during altered nutrient status.” Am J Physiol 268, no. 4 Pt 1 (April 1995): G631–40. https://doi.org/10.1152/ajpgi.1995.268.4.G631.
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  - Lyles, C. M., R. S. Sandler, T. O. Keku, L. L. Kupper, R. C. Millikan, S. C. Murray, S. I. Bangdiwala, and M. H. Ulshen. “Reproducibility and variability of the rectal mucosal proliferation index using proliferating cell nuclear antigen immunohistochemistry.” Cancer Epidemiol Biomarkers Prev 3, no. 7 (October 1994): 597–605.
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  - Garfunkel, J. M., M. H. Ulshen, H. J. Hamrick, and E. E. Lawson. “Effect of institutional prestige on reviewers' recommendations and editorial decisions.” Jama 272, no. 2 (July 13, 1994): 137–38.
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  - Ferry, G. D., B. S. Kirschner, R. J. Grand, R. M. Issenman, A. M. Griffiths, J. A. Vanderhoof, S. C. Fiedorek, H. S. Winter, E. G. Hassall, and J. B. Watkins. “Olsalazine versus sulfasalazine in mild to moderate childhood ulcerative colitis: results of the Pediatric Gastroenterology Collaborative Research Group Clinical Trial.” J Pediatr Gastroenterol Nutr 17, no. 1 (July 1993): 32–38. https://doi.org/10.1097/00005176-199307000-00005.
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  - Ulshen, M. H., R. H. Dowling, C. R. Fuller, E. M. Zimmermann, and P. K. Lund. “Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone.” Gastroenterology 104, no. 4 (April 1993): 973–80. https://doi.org/10.1016/0016-5085(93)90263-c.
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  - Lund, P. K., E. Hoyt, J. G. Simmons, and M. H. Ulshen. “Regulation of intestinal glucagon gene expression during adaptive growth of small intestine.” Digestion 54, no. 6 (January 1, 1993): 371–73. https://doi.org/10.1159/000201058.
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  - Markowitz, J., K. Grancher, F. Mandel, and F. Daum. “Immunosuppressive therapy in pediatric inflammatory bowel disease: results of a survey of the North American Society for Pediatric Gastroenterology and Nutrition. Subcommittee on Immunosuppressive Use of the Pediatric IBD Collaborative Research Forum.” Am J Gastroenterol 88, no. 1 (January 1993): 44–48.
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  - Sandler, R. S., M. H. Ulshen, C. M. Lyles, C. A. McAuliffe, and C. R. Fuller. “Rectal mucosal ornithine decarboxylase activity is not a useful marker of risk for colorectal neoplasia.” Dig Dis Sci 37, no. 11 (November 1992): 1718–24. https://doi.org/10.1007/BF01299865.
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  - Rountree, D. B., M. H. Ulshen, S. Selub, C. R. Fuller, S. R. Bloom, M. A. Ghatei, and P. K. Lund. “Nutrient-independent increases in proglucagon and ornithine decarboxylase messenger RNAs after jejunoileal resection.” Gastroenterology 103, no. 2 (August 1992): 462–68. https://doi.org/10.1016/0016-5085(92)90835-m.
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  - Ulshen, M. H., J. G. Lecce, A. D. Stiles, and L. E. Lyn-Cook. “Effects of nursing on growth and development of small bowel mucosa in newborn piglets.” Pediatr Res 30, no. 4 (October 1991): 337–41. https://doi.org/10.1203/00006450-199110000-00009.
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  - Markowitz, J., F. Daum, S. A. Cohen, M. Glassman, R. D. Holmes, D. Piccoli, T. M. Rossi, W. R. Treem, M. H. Ulshen, and H. S. Winter. “Immunology of inflammatory bowel disease: summary of the proceedings of the Subcommittee on Immunosuppressive Use in IBD.” J Pediatr Gastroenterol Nutr 12, no. 4 (May 1991): 411–23.
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  - Ulshen, M. H. “Routine laparoscopy in the management of chronic hepatitis.” J Pediatr 117, no. 3 (September 1990): 417–18. https://doi.org/10.1016/s0022-3476(05)81082-0.
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  - Garfunkel, J. M., E. E. Lawson, H. J. Hamrick, and M. H. Ulshen. “Effect of acceptance or rejection on the author's evaluation of peer review of medical manuscripts.” Jama 263, no. 10 (March 9, 1990): 1376–78.
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  - Garfunkel, J. M., M. H. Ulshen, H. J. Hamrick, and E. E. Lawson. “Problems identified by secondary review of accepted manuscripts.” Jama 263, no. 10 (March 9, 1990): 1369–71.
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  - Lund, P. K., M. H. Ulshen, D. B. Rountree, S. E. Selub, and A. M. Buchan. “Molecular biology of gastrointestinal peptides and growth factors: relevance to intestinal adaptation.” Digestion 46 Suppl 2 (1990): 66–73. https://doi.org/10.1159/000200369.
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  - Ulshen, M. H., and J. M. Garfunkel. “The editorial process of evaluation and selection of manuscripts: Experience at the Journal of Pediatrics.” Serials Review 16, no. 2 (January 1, 1990): 29–31. https://doi.org/10.1016/0098-7913(90)90003-H.
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  - Kleinman, R. E., N. F. Galeano, F. Ghishan, E. Lebenthal, J. Sutphen, and M. H. Ulshen. “Nutritional management of chronic diarrhea and/or malabsorption.” J Pediatr Gastroenterol Nutr 9, no. 4 (November 1989): 407–15. https://doi.org/10.1097/00005176-198911000-00002.
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  - Ulshen, M. “α₁-Antitrypsin deficiency: Two wrongs can make a right.” Gastroenterology 97, no. 1 (1989): 225–26.
  - Ulshen, M. “Unraveling sucrase-isomaltase "deficiency" states.” Gastroenterology 96, no. 1 (1989): 259–60.
  - Bishop, W. P., and M. H. Ulshen. “Bacterial gastroenteritis.” Pediatr Clin North Am 35, no. 1 (February 1988): 69–87. https://doi.org/10.1016/s0031-3955(16)36400-8.
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  - Ulshen, M. H. “Refeeding during recovery from acute diarrhea.” J Pediatr 112, no. 2 (February 1988): 239–40. https://doi.org/10.1016/s0022-3476(88)80061-1.
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  - Ulshen, M. H. “Gastroesophageal reflux in infancy.” Gastroenterology 95, no. 2 (January 1, 1988): 534–35. https://doi.org/10.1016/0016-5085(88)90517-3.
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  - Ulshen, M. H. “Treatment of gastroesophageal reflux: is nothing sacred?” J Pediatr 110, no. 2 (February 1987): 254–55. https://doi.org/10.1016/s0022-3476(87)80165-8.
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  - Groben, P. A., G. P. Siegal, M. D. Shub, M. H. Ulshen, and F. B. Askin. “Gastroesophageal reflux and esophagitis in infants and children.” Perspect Pediatr Pathol 11 (1987): 124–51.
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  - Ulshen, M. H. “Natural history of Cryptosporidia.” Gastroenterology 93, no. 1 (January 1, 1987): 205–6. https://doi.org/10.1016/0016-5085(87)90338-6.
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  - Ulshen, M. H. “Liver transplantation in the infant.” Gastroenterology 93, no. 5 (January 1, 1987): 1139–40. https://doi.org/10.1016/0016-5085(87)90586-5.
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  - Ulshen, M. H. “To dry or not to dry, that is the question.” Gastroenterology 92, no. 2 (January 1, 1987): 542–43. https://doi.org/10.1016/0016-5085(87)90159-4.
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  - Ulshen, M. H., L. E. Lyn-Cook, and R. H. Raasch. “Effects of intraluminal epidermal growth factor on mucosal proliferation in the small intestine of adult rats.” Gastroenterology 91, no. 5 (November 1986): 1134–40. https://doi.org/10.1016/s0016-5085(86)80008-7.
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  - Tobey, N. A., L. E. Lyn-Cook, M. H. Ulshen, and W. D. Heizer. “Intestinal brush border peptidases: activities in normal and abnormal peroral intestinal biopsy specimens.” J Lab Clin Med 107, no. 3 (March 1986): 221–27.
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  - Ulshen, M. H. “Salicylates and Reye's syndrome.” Gastroenterology 91, no. 2 (January 1, 1986): 487–88. https://doi.org/10.1016/0016-5085(86)90594-9.
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  - Ulshen, M. H. “To treat or not to treat.” Gastroenterology 91, no. 6 (January 1, 1986): 1569–70. https://doi.org/10.1016/0016-5085(86)90218-0.
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  - Ulshen, M. H. “A promising rotavirus vaccine.” Gastroenterology 90, no. 1 (January 1, 1986): 246–47. https://doi.org/10.1016/0016-5085(86)90105-8.
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  - Shub, M. D., M. H. Ulshen, C. B. Hargrove, G. P. Siegal, P. A. Groben, and F. B. Askin. “Esophagitis: a frequent consequence of gastroesophageal reflux in infancy.” J Pediatr 107, no. 6 (December 1985): 881–84. https://doi.org/10.1016/s0022-3476(85)80180-3.
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  - Ulshen, M. H., and C. A. Herbst. “Effect of proximal transposition of the ileum on mucosal growth and enzyme activity in orally nourished rats.” Am J Clin Nutr 42, no. 5 (November 1985): 805–14. https://doi.org/10.1093/ajcn/42.5.805.
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  - Ulshen, M. H. “Guilt not by association.” Gastroenterology 89, no. 6 (January 1, 1985): 1436–37. https://doi.org/10.1016/0016-5085(85)90668-7.
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  - Ulshen, M. H. “Drink your milk!.” Gastroenterology 89, no. 3 (January 1, 1985): 695–96. https://doi.org/10.1016/0016-5085(85)90476-7.
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  - Ulshen, M. H. “Screening for celiac disease: Are we there yet?” Gastroenterology 89, no. 1 (January 1, 1985): 217–18. https://doi.org/10.1016/0016-5085(85)90767-X.
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  - Ulshen, M. H. “Is polyamine biosynthesis necessary for intestinal adaptation?” Gastroenterology 88, no. 6 (January 1, 1985): 2006–7. https://doi.org/10.1016/0016-5085(85)90036-8.
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  - Ulshen, M. H. “Vitamin E in cholestasis.” Gastroenterology 88, no. 2 (January 1, 1985): 588–89. https://doi.org/10.1016/0016-5085(85)90526-8.
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  - Hargrove, C. B., M. H. Ulshen, and M. D. Shub. “Upper gastrointestinal endoscopy in infants: diagnostic usefulness and safety.” Pediatrics 74, no. 5 (November 1984): 828–31.
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  - Powell, T. W., C. A. Herbst, and M. Ulshen. “Mallory-Weiss syndrome in a 10-month-old infant requiring surgery.” Journal of Pediatric Surgery 19, no. 5 (October 1984): 596–97. https://doi.org/10.1016/s0022-3468(84)80113-x.
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  - Long, W. A., M. H. Ulshen, and E. E. Lawson. “Clinical manifestations of congenital syphilitic hepatitis: implications for pathogenesis.” J Pediatr Gastroenterol Nutr 3, no. 4 (September 1984): 551–55. https://doi.org/10.1097/00005176-198409000-00013.
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  - Stafford, S. J., M. H. Ulshen, and J. Mandell. “Familial visceral myopathy.” J Urol 131, no. 5 (May 1984): 978–80. https://doi.org/10.1016/s0022-5347(17)50737-5.
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  - Ulshen, M. H., and C. A. Herbst. “Effect of removal of pancreaticobiliary secretions on adaptation to short bowel in orally nourished rats.” Am J Clin Nutr 39, no. 5 (May 1984): 762–70. https://doi.org/10.1093/ajcn/39.5.762.
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  - Ulshen, M. H. “To shunt or not to shunt?” Gastroenterology 87, no. 2 (January 1, 1984): 446–47. https://doi.org/10.1016/0016-5085(84)90734-0.
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  - Ulshen, M. H. “Would you believe the tongue?” Gastroenterology 87, no. 3 (January 1, 1984): 732–33. https://doi.org/10.1016/0016-5085(84)90553-5.
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  - Schwarz, R. P., and M. H. Ulshen. “Pseudomembranous colitis presenting as mild, chronic diarrhea in childhood.” J Pediatr Gastroenterol Nutr 2, no. 3 (1983): 570–73. https://doi.org/10.1097/00005176-198302030-00030.
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  - Devore, C. D., M. H. Ulshen, and R. E. Cross. “Phenolphthalein laxatives and factitious diarrhea.” Clin Pediatr (Phila) 21, no. 9 (September 1982): 573–74. https://doi.org/10.1177/000992288202100911.
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  - Everett, C., F. Volberg, M. Ulshen, and G. Murray. “Intramural esophageal hamartoma: a report of two cases and review of the literature.” Gastrointest Radiol 5, no. 4 (November 15, 1980): 317–19. https://doi.org/10.1007/BF01888651.
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  - Ulshen, M. H., and J. L. Rollo. “Pathogenesis of escherichia coli gastroenteritis in man--another mechanism.” N Engl J Med 302, no. 2 (January 10, 1980): 99–101. https://doi.org/10.1056/NEJM198001103020207.
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  - Ulshen, M. H., and R. J. Grand. “Site of substrate stimulation of jejunal sucrase in the rat.” J Clin Invest 64, no. 4 (October 1979): 1097–1102. https://doi.org/10.1172/JCI109548.
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  - Ulshen, M. H., R. J. Grand, J. D. Crain, and E. W. Gelfand. “Hepatoxicity with encephalopathy associated with aspirin therapy in rheumatoid arthritis.” J Pediatr 93, no. 6 (December 1978): 1034–37. https://doi.org/10.1016/s0022-3476(78)81252-9.
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  - Ulshen, M. H., and R. J. Grand. “Effects of cholestyramine on small intestinal mucosa.” Pediatric Research 12, no. 4 II (January 1, 1978).
  - Grand, R. J., and M. H. Ulshen. “Clinical and physiological abnormalities in hepatic function.” Pediatr Clin North Am 22, no. 4 (November 1975): 897–928. https://doi.org/10.1016/s0031-3955(16)33215-1.
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Education, Training, & Certifications

Duke Appointment History

Selected Grants

Selected Publications

Academic Articles