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Mary E Klotman

R.J. Reynolds Distinguished Professor of Medicine
Medicine, Infectious Diseases
DUMC 2927, Davison Building Room 125, Durham, NC 27710
Davison Building Room 125, Box 2927, Durham, NC 27710


Dr. Klotman became Dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement.)

Current Appointments & Affiliations

R.J. Reynolds Distinguished Professor of Medicine · 2011 - Present Medicine, Infectious Diseases, Medicine
Professor of Medicine · 2010 - Present Medicine, Infectious Diseases, Medicine
Dean, School of Medicine · 2017 - Present School of Medicine
Executive Vice President of Health Affairs · 2023 - Present School of Medicine
Professor in Molecular Genetics and Microbiology · 2011 - Present Molecular Genetics and Microbiology, Basic Science Departments
Professor of Pathology · 2013 - Present Pathology, Clinical Science Departments
Member of the Duke Human Vaccine Institute · 2010 - Present Duke Human Vaccine Institute, Institutes and Centers

Education, Training & Certifications

Duke University · 1980 M.D.