Mary E Klotman | Scholars@Duke

Mary E Klotman
R.J. Reynolds Professor of Medicine

Dr. Klotman became dean of the Duke School of Medicine in June 2017.

An accomplished clinician and scientist, Klotman’s research interests are focused on the molecular pathogenesis of Human Immunodeficiency Virus 1 (HIV-1) infection.

Among many important contributions to this field, Klotman and her team demonstrated that HIV resides in and evolves separately in kidney cells, a critical step in HIV-associated kidney disease. Her research group also has determined the role of soluble host factors involved in an innate immune response to HIV in an effort to improve prevention strategies, topical microbicides that could be used to block sexual transmission of HIV.

Most recently, her group has been defining the role of integrase-defective lentiviral vectors for the delivery of an HIV vaccine. (Read the announcement. )

Current Appointments & Affiliations

R.J. Reynolds Professor of Medicine, Medicine, Infectious Diseases, Medicine 2011
Professor of Medicine, Medicine, Infectious Diseases, Medicine 2010
Dean, School of Medicine, School of Medicine, Duke University 2017
Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2011
Professor of Pathology, Pathology, Clinical Science Departments 2013
Member of the Duke Human Vaccine Institute, Duke Human Vaccine Institute, Institutes and Centers 2010

Contact Information

DUMC 2927, Davison Building Room 125, Durham, NC 27710
Davison Building Room 125, Box 2927, Durham, NC 27710
mary.klotman@duke.edu (919) 684-2455
Department of Medicine - Leadership

Background
Education, Training, & Certifications
- Fellow in Infectious Diseases, Medicine, Duke University 1983 - 1985
- Resident, Medicine, Duke University 1980 - 1983
- M.D., Duke University 1980
Duke Appointment History
- Chair, Department of Medicine, Medicine, Clinical Science Departments 2010 - 2017
- Consulting Associate in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2010
- Assistant Professor, Medicine, Clinical Science Departments 1986 - 1990
- Associate, Medicine, Clinical Science Departments 1985 - 1986
Recognition
In the News
- MAY 18, 2018 Viewpoints podcast
  
  What's Duke Doing to Better Understand and Treat Brain Diseases?
- MAR 5, 2018 Viewpoints podcast
  
  Why is it Important to Explore the Early-life Origins of Health and Disease?
- JAN 19, 2018 Viewpoint podcast
  
  Dean Mary Klotman on Translating Duke Health
- NOV 2, 2017 School of Medicine Viewpoint Podcast
  
  Mary Klotman: What Did it Take to Change HIV From a Fatal Diagnosis to an Often-manageable, Disease?
- OCT 10, 2017 School of Medicine Viewpoint
  
  Mary Klotman: What is Data Science and Why Is It Important?
- AUG 29, 2017
  
  Dr. Mary Klotman: Why Diversity Is Necessary in Academic Medicine
- JUL 11, 2017
  
  From Undergraduate to Dean: Dr. Mary Klotman Describes What She Has Learned at Duke
- MAY 25, 2017 School of Medicine
  
  Duke Hosts Precision Medicine World Conference
- APR 24, 2017 Duke School of Medicine
  
  Klotman Joins Roundtable Discussion with Rep. David Price to Discuss NIH Budget
- JAN 30, 2017
  
  Dr. Mary Klotman Named Dean of Duke School of Medicine
- APR 6, 2015 The News & Observer
  
  Duke HIV researchers receive large federal grants
- APR 5, 2015
  
  Duke Research Teams Win Large Federal Grants for HIV Vaccine Studies
- OCT 21, 2014
  
  Klotman, chair of Medicine, Named to Institute of Medicine
Awards & Honors
- Member. Institute of Medicine of The National Academies. 2014
- Membership. National Academy of Medicine. 2014
Expertise
Subject Headings
Research
Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Mentoring Patient Oriented Research in Antibiotic-Resistant Bacteria awarded by National Institutes of Health 2011 - 2021
- Transmission electron microscope (TEM) awarded by National Institutes of Health 2019 - 2020
- Interdisciplinary Research Training Program in AIDS awarded by National Institutes of Health 2010 - 2020
- Interdisciplinary Research Training Program in AIDS awarded by National Institutes of Health 2010 - 2020
- The Genitourinary Tract as a compartment and reservoir for HIV awarded by National Institutes of Health 2015 - 2020
- The Genitourinary Tract as a compartment and reservoir for HIV awarded by National Institutes of Health 2015 - 2020
- Persistent HIV Infection in the Kidney awarded by Baylor College of Medicine 1999 - 2020
- Integrase Defective Lentiviral Vector (IDLV) for HIV Vaccine Development awarded by National Institutes of Health 2015 - 2020
- Viral Oncology Training Grant awarded by National Institutes of Health 1980 - 2019
- Persistent HIV Infection in the Kidney awarded by Baylor College of Medicine 1999 - 2019
- Systems Biology Approaches for Predicting Cardiometabolic Risk in Persons Living with HIV awarded by National Institutes of Health 2015 - 2018
- Serial Block Face Scanning Electron Microscope awarded by National Institutes of Health 2016 - 2018
- Impact of polyploidy on establishing an HIV-1 reservoir in the kidney awarded by University of Alabama at Birmingham 2014 - 2017
- The Pathogenesis of HIV-Associated Nephropathy awarded by Baylor College of Medicine 2011 - 2016
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Blasi, Maria, Donatella Negri, Celia LaBranche, S Munir Alam, Erich J. Baker, Elizabeth C. Brunner, Morgan A. Gladden, et al. “IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells..” Commun Biol 1 (2018). https://doi.org/10.1038/s42003-018-0131-6.
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  - Negri, Donatella, Maria Blasi, Celia LaBranche, Robert Parks, Harikrishnan Balachandran, Michelle Lifton, Xiaoying Shen, et al. “Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques..” Mol Ther 24, no. 11 (November 2016): 2021–32. https://doi.org/10.1038/mt.2016.123.
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  - Chen, Ping, Zhengzi Yi, Weijia Zhang, Mary E. Klotman, and Benjamin K. Chen. “HIV infection-induced transcriptional program in renal tubular epithelial cells activates a CXCR2-driven CD4+ T-cell chemotactic response..” Aids 30, no. 12 (July 31, 2016): 1877–88. https://doi.org/10.1097/QAD.0000000000001153.
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  - Blasi, Maria, J Harris Carpenter, Bala Balakumaran, Andrea Cara, Feng Gao, and Mary E. Klotman. “Identification of HIV-1 genitourinary tract compartmentalization by analyzing the env gene sequences in urine..” Aids 29, no. 13 (August 24, 2015): 1651–57. https://doi.org/10.1097/QAD.0000000000000757.
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  - Michelini, Zuleika, Donatella Negri, Mirella Biava, Silvia Baroncelli, Massimo Spada, Pasqualina Leone, Roberta Bona, et al. “Murine granulocyte-macrophage colony-stimulating factor expressed from a bicistronic simian immunodeficiency virus-based integrase-defective lentiviral vector does not enhance T-cell responses in mice..” Viral Immunol 27, no. 10 (December 2014): 512–20. https://doi.org/10.1089/vim.2014.0062.
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  - Carethers, J. M., S. Coughlin, B. Diamond, S. Erzurum, L. P. Fried, J. L. Jameson, K. Kaushansky, et al. “The imperative to invest in science has never been greater..” J Clin Invest 124, no. 11 (November 3, 2014). https://doi.org/10.1172/JCI79469.
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  - Blasi, Maria, Bala Balakumaran, Ping Chen, Donatella R. M. Negri, Andrea Cara, Benjamin K. Chen, and Mary E. Klotman. “Renal epithelial cells produce and spread HIV-1 via T-cell contact..” Aids 28, no. 16 (October 23, 2014): 2345–53. https://doi.org/10.1097/QAD.0000000000000398.
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  - Carethers, John M., Shaun Coughlin, Betty Diamond, Serpil Erzurum, Linda P. Fried, J Larry Jameson, Kenneth Kaushansky, et al. “The imperative to invest in science has never been greater..” J Clin Invest 124, no. 9 (September 2014): 3680–81. https://doi.org/10.1172/JCI77894.
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  - Rossi, Alessandra, Zuleika Michelini, Pasqualina Leone, Martina Borghi, Maria Blasi, Roberta Bona, Massimo Spada, et al. “Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector..” Plos One 9, no. 9 (2014). https://doi.org/10.1371/journal.pone.0107377.
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  - Micsenyi, Amanda M., Chati Zony, Raymond A. Alvarez, Natasha D. Durham, Benjamin K. Chen, and Mary E. Klotman. “Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells..” J Infect Dis 208, no. 11 (December 1, 2013): 1756–67. https://doi.org/10.1093/infdis/jit362.
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  - Hutter, Randolph, Li Huang, Walter S. Speidl, Chiara Giannarelli, Paul Trubin, Gerhard Bauriedel, Mary E. Klotman, Valentin Fuster, Juan J. Badimon, and Paul E. Klotman. “Novel small leucine-rich repeat protein podocan is a negative regulator of migration and proliferation of smooth muscle cells, modulates neointima formation, and is expressed in human atheroma..” Circulation 128, no. 22 (November 26, 2013): 2351–63. https://doi.org/10.1161/CIRCULATIONAHA.113.004634.
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  - Todd, Robert F., Robert A. Salata, Mary E. Klotman, Myron L. Weisfeldt, Joel T. Katz, Sherry X. Xian, Darren P. Hearn, and Rebecca S. Lipner. “Career outcomes of the graduates of the American Board of Internal Medicine Research Pathway, 1995-2007..” Acad Med 88, no. 11 (November 2013): 1747–53. https://doi.org/10.1097/ACM.0b013e3182a7f627.
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  - Blasi, M., A. Rossi, Z. Michelini, P. Leone, G. Perretta, A. Cimarelli, M. E. Klotman, D. Negri, and A. Cara. “Simian immunodeficiency virus-Vpx as an adjuvant for integrase defective lentiviral vector-based vaccines.” Retrovirology 9, no. S2 (September 2012). https://doi.org/10.1186/1742-4690-9-s2-p293.
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  - Negri, Donatella R. M., Alessandra Rossi, Maria Blasi, Zuleika Michelini, Pasqualina Leone, Maria Vincenza Chiantore, Silvia Baroncelli, et al. “Simian immunodeficiency virus-Vpx for improving integrase defective lentiviral vector-based vaccines..” Retrovirology 9 (August 22, 2012). https://doi.org/10.1186/1742-4690-9-69.
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  - Papeta, Natalia, Krzysztof Kiryluk, Ami Patel, Roel Sterken, Nilgun Kacak, Holly J. Snyder, Phil H. Imus, et al. “APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy..” J Am Soc Nephrol 22, no. 11 (November 2011): 1991–96. https://doi.org/10.1681/ASN.2011040434.
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  - Jao, Jennifer, Dennis Palmer, Ine Leus, Pius Tih, Mukta Baweja, Mary Klotman, Rhoda Sperling, and Christina Wyatt. “Prevalence and predictors of proteinuria in HIV-infected and uninfected pregnant women in Cameroon..” Nephrol Dial Transplant 26, no. 9 (September 2011): 3051–53. https://doi.org/10.1093/ndt/gfr310.
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  - Chen, Ping, Benjamin K. Chen, Arevik Mosoian, Thomas Hays, Michael J. Ross, Paul E. Klotman, and Mary E. Klotman. “Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells..” J Am Soc Nephrol 22, no. 3 (March 2011): 496–507. https://doi.org/10.1681/ASN.2010040379.
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  - Ding, Jian, Aprille Rapista, Natalia Teleshova, Wuyuan Lu, Mary E. Klotman, and Theresa L. Chang. “Mucosal human defensins 5 and 6 antagonize the anti-HIV activity of candidate polyanion microbicides..” J Innate Immun 3, no. 2 (2011): 208–12. https://doi.org/10.1159/000322355.
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  - Chang, T. L., and M. Klotman. “Defensins and HIV infection,” December 1, 2010, 51–63. https://doi.org/10.2174/9781608050062110010151.
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  - Negri, Donatella R. M., Roberta Bona, Zuleika Michelini, Pasqualina Leone, Iole Macchia, Mary E. Klotman, Mirella Salvatore, and Andrea Cara. “Transduction of human antigen-presenting cells with integrase-defective lentiviral vector enables functional expansion of primed antigen-specific CD8(+) T cells..” Hum Gene Ther 21, no. 8 (August 2010): 1029–35. https://doi.org/10.1089/hum.2009.200.
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  - Tuyama, Ana C., Feng Hong, Yedidya Saiman, Chuansheng Wang, Derya Ozkok, Arevik Mosoian, Ping Chen, Benjamin K. Chen, Mary E. Klotman, and Meena B. Bansal. “Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: implications for the pathogenesis of HIV/hepatitis C virus-induced liver fibrosis..” Hepatology 52, no. 2 (August 2010): 612–22. https://doi.org/10.1002/hep.23679.
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  - Mosoian, Arevik, Avelino Teixeira, Colin S. Burns, Leif E. Sander, G Luca Gusella, Cijiang He, J Magarian Blander, Paul Klotman, and Mary E. Klotman. “Prothymosin-alpha inhibits HIV-1 via Toll-like receptor 4-mediated type I interferon induction..” Proc Natl Acad Sci U S A 107, no. 22 (June 1, 2010): 10178–83. https://doi.org/10.1073/pnas.0914870107.
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  - Snyder, Alexandra, Zygimantas C. Alsauskas, Jeremy S. Leventhal, Paul E. Rosenstiel, Pengfei Gong, Justin J. K. Chan, Kevin Barley, et al. “HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells..” Aids (London, England) 24, no. 8 (May 2010): 1107–19. https://doi.org/10.1097/QAD.0b013e328337b0ab.
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  - Ding, Jian, Aprille Rapista, Natalia Teleshova, Goar Mosoyan, Gary A. Jarvis, Mary E. Klotman, and Theresa L. Chang. “Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation..” J Immunol 184, no. 6 (March 15, 2010): 2814–24. https://doi.org/10.4049/jimmunol.0902125.
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  - Negri, Donatella R. M., Zuleika Michelini, Silvia Baroncelli, Massimo Spada, Silvia Vendetti, Roberta Bona, Pasqualina Leone, Mary E. Klotman, and Andrea Cara. “Nonintegrating Lentiviral Vector-Based Vaccine Efficiently Induces Functional and Persistent CD8+ T Cell Responses in Mice..” J Biomed Biotechnol 2010 (2010). https://doi.org/10.1155/2010/534501.
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  - Snyder, Alexandra, Zygimantas Alsauskas, Pengfei Gong, Paul E. Rosenstiel, Mary E. Klotman, Paul E. Klotman, and Michael J. Ross. “FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy..” Journal of Virology 83, no. 22 (November 2009): 11983–88. https://doi.org/10.1128/JVI.00034-09.
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  - Factor, Stephanie H., and Mary E. Klotman. “Zoonotic infections: an emerging threat to human health..” Mt Sinai J Med 76, no. 5 (October 2009): 419–20. https://doi.org/10.1002/msj.20141.
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  - Feng, Xiaobei, Ting-Chi Lu, Peter Y. Chuang, Wei Fang, Krishna Ratnam, Huabao Xiong, Xinshou Ouyang, et al. “Reduction of Stat3 activity attenuates HIV-induced kidney injury..” J Am Soc Nephrol 20, no. 10 (October 2009): 2138–46. https://doi.org/10.1681/ASN.2008080879.
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  - Rosenstiel, Paul E., Justin Chan, Alexander Snyder, Vicente Planelles, Vivette D. D’Agati, Paul E. Klotman, and Mary E. Klotman. “HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells..” Aids 23, no. 15 (September 24, 2009): 2054–56. https://doi.org/10.1097/QAD.0b013e32833088a0.
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  - Chen, Wen-Hua, Vaclav Janout, Masaharu Kondo, Arevik Mosoian, Goar Mosoyan, Ravil R. Petrov, Mary E. Klotman, and Steven L. Regen. “A fine line between molecular umbrella transport and ionophoric activity..” Bioconjug Chem 20, no. 9 (September 2009): 1711–15. https://doi.org/10.1021/bc900246u.
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  - Michelini, Zuleika, Donatella R. M. Negri, Silvia Baroncelli, Massimo Spada, Pasqualina Leone, Roberta Bona, Mary E. Klotman, and Andrea Cara. “Development and use of SIV-based Integrase defective lentiviral vector for immunization..” Vaccine 27, no. 34 (July 23, 2009): 4622–29. https://doi.org/10.1016/j.vaccine.2009.05.070.
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  - Sachdev, Darpun D., Bouchra Zerhouni-Layachi, Mila Ortigoza, Albert T. Profy, Michael Tuen, Catarina E. Hioe, and Mary E. Klotman. “The differential binding and activity of PRO 2000 against diverse HIV-1 envelopes..” Journal of Acquired Immune Deficiency Syndromes (1999) 51, no. 2 (June 2009): 125–29. https://doi.org/10.1097/QAI.0b013e31819f9e31.
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  - Wyatt, Christina M., Susan Morgello, Rebecca Katz-Malamed, Catherine Wei, Mary E. Klotman, Paul E. Klotman, and Vivette D. D’Agati. “The spectrum of kidney disease in patients with AIDS in the era of antiretroviral therapy..” Kidney Int 75, no. 4 (February 2009): 428–34. https://doi.org/10.1038/ki.2008.604.
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  - Abbadessa, Giovanni, Roberto Accolla, Fernando Aiuti, Adriana Albini, Anna Aldovini, Massimo Alfano, Guido Antonelli, et al. “Unsung hero Robert C. Gallo..” Science 323, no. 5911 (January 9, 2009): 206–7. https://doi.org/10.1126/science.323.5911.206.
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  - Radbill, B. D., C. M. Wyatt, J. A. Vassalotti, M. E. Klotman, and P. E. Klotman. “Hepatitis B- and HIV-Related Renal Diseases,” December 1, 2008, 272–80. https://doi.org/10.1016/B978-141605484-9.50026-5.
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  - Vargas, J., M. E. Klotman, and A. Cara. “Conditionally replicating lentiviral-hybrid episomal vectors for suicide gene therapy..” Antiviral Res 80, no. 3 (December 2008): 288–94. https://doi.org/10.1016/j.antiviral.2008.06.015.
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  - Rosenstiel, Paul E., Tina Gruosso, Audrey M. Letourneau, Justin J. Chan, Amanda LeBlanc, Mohammad Husain, Vesna Najfeld, et al. “HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells..” Kidney Int 74, no. 8 (October 2008): 1049–58. https://doi.org/10.1038/ki.2008.303.
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  - Klotman, Mary E., Aprille Rapista, Natalia Teleshova, Amanda Micsenyi, Gary A. Jarvis, Wuyuan Lu, Edith Porter, and Theresa L. Chang. “Neisseria gonorrhoeae-induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission..” J Immunol 180, no. 9 (May 1, 2008): 6176–85. https://doi.org/10.4049/jimmunol.180.9.6176.
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  - Teleshova, Natalia, Theresa Chang, Albert Profy, and Mary E. Klotman. “Inhibitory effect of PRO 2000, a candidate microbicide, on dendritic cell-mediated human immunodeficiency virus transfer..” Antimicrobial Agents and Chemotherapy 52, no. 5 (May 2008): 1751–58. https://doi.org/10.1128/AAC.00707-07.
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  - Eugenin, Eliseo A., Susan Morgello, Mary E. Klotman, Arevik Mosoian, Patrick A. Lento, Joan W. Berman, and Alison D. Schecter. “Human immunodeficiency virus (HIV) infects human arterial smooth muscle cells in vivo and in vitro: implications for the pathogenesis of HIV-mediated vascular disease..” Am J Pathol 172, no. 4 (April 2008): 1100–1111. https://doi.org/10.2353/ajpath.2008.070457.
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  - Chang, Theresa L., Natalia Teleshova, Aprille Rapista, Maciej Paluch, Robert A. Anderson, Donald P. Waller, Lourens J. D. Zaneveld, Angela Granelli-Piperno, and Mary E. Klotman. “SAMMA, a mandelic acid condensation polymer, inhibits dendritic cell-mediated HIV transmission..” Febs Lett 581, no. 24 (October 2, 2007): 4596–4602. https://doi.org/10.1016/j.febslet.2007.08.048.
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  - Wyatt, Christina M., Jonathan A. Winston, Carlos D. Malvestutto, Dawn A. Fishbein, Irina Barash, Alan J. Cohen, Mary E. Klotman, and Paul E. Klotman. “Chronic kidney disease in HIV infection: an urban epidemic..” Aids 21, no. 15 (October 1, 2007): 2101–3. https://doi.org/10.1097/QAD.0b013e3282ef1bb4.
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  - Salvatore, Mirella, Adolfo Garcia-Sastre, Piotr Ruchala, Robert I. Lehrer, Theresa Chang, and Mary E. Klotman. “alpha-Defensin inhibits influenza virus replication by cell-mediated mechanism(s)..” J Infect Dis 196, no. 6 (September 15, 2007): 835–43. https://doi.org/10.1086/521027.
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  - Mosoian, Arevik, Avelino Teixeira, Colin S. Burns, Gregory Khitrov, Weijia Zhang, Luca Gusella, Paul Klotman, and Mary Klotman. “Influence of prothymosin-alpha on HIV-1 target cells..” Ann N Y Acad Sci 1112 (September 2007): 269–85. https://doi.org/10.1196/annals.1415.043.
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  - Negri, Donatella R. M., Zuleika Michelini, Silvia Baroncelli, Massimo Spada, Silvia Vendetti, Viviana Buffa, Roberta Bona, Pasqualina Leone, Mary E. Klotman, and Andrea Cara. “Successful immunization with a single injection of non-integrating lentiviral vector..” Mol Ther 15, no. 9 (September 2007): 1716–23. https://doi.org/10.1038/sj.mt.6300241.
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  - Negri, Donatella R. M., Zuleika Michelini, Silvia Baroncelli, Massimo Spada, Silvia Vendetti, Viviana Buffa, Roberta Bona, Pasqualina Leone, Mary E. Klotman, and Andrea Cara. “Successful immunization with a single injection of non-integrating lentiviral vector.” Molecular Therapy 15, no. 9 (September 1, 2007): 1716–23. https://doi.org/10.1038/sj.mt.6300241.
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  - Bhadelia, Nahid, Mary Klotman, and Daniel Caplivski. “The HIV-positive traveler..” Am J Med 120, no. 7 (July 2007): 574–80. https://doi.org/10.1016/j.amjmed.2007.02.018.
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  - Kaufman, Lewis, Guozhe Yang, Kayo Hayashi, James R. Ashby, Li Huang, Michael J. Ross, Mary E. Klotman, and Paul E. Klotman. “The homophilic adhesion molecule sidekick-1 contributes to augmented podocyte aggregation in HIV-associated nephropathy..” Faseb J 21, no. 7 (May 2007): 1367–75. https://doi.org/10.1096/fj.06-7191com.
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  - Cara, Andrea, and Mary E. Klotman. “Retroviral E-DNA: persistence and gene expression in nondividing immune cells..” J Leukoc Biol 80, no. 5 (November 2006): 1013–17. https://doi.org/10.1189/jlb.0306151.
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  - Liu, Xinyan, Arevik Mosoian, Theresa Li-Yun Chang, Bouchra Zerhouni-Layachi, Alexandra Snyder, Gary A. Jarvis, and Mary E. Klotman. “Gonococcal lipooligosaccharide suppresses HIV infection in human primary macrophages through induction of innate immunity..” J Infect Dis 194, no. 6 (September 15, 2006): 751–59. https://doi.org/10.1086/506360.
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  - Tuyama, Ana C. G., Natalia Cheshenko, Maria J. Carlucci, Jin-Hua Li, Cindy L. Goldberg, Donald P. Waller, Robert A. Anderson, et al. “ACIDFORM inactivates herpes simplex virus and prevents genital herpes in a mouse model: optimal candidate for microbicide combinations..” J Infect Dis 194, no. 6 (September 15, 2006): 795–803. https://doi.org/10.1086/506948.
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  - Mosoian, Arevik, Avelino Teixeira, Anthony A. High, Robert E. Christian, Donald F. Hunt, Jeffrey Shabanowitz, Xinyan Liu, and Mary Klotman. “Novel function of prothymosin alpha as a potent inhibitor of human immunodeficiency virus type 1 gene expression in primary macrophages..” J Virol 80, no. 18 (September 2006): 9200–9206. https://doi.org/10.1128/JVI.00589-06.
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  - Klotman, Mary E., and Theresa L. Chang. “Defensins in innate antiviral immunity..” Nat Rev Immunol 6, no. 6 (June 2006): 447–56. https://doi.org/10.1038/nri1860.
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  - Ross, Michael J., Cheng Fan, Michael D. Ross, Te-Huatearina Chu, Yueyue Shi, Lewis Kaufman, Weijia Zhang, Mary E. Klotman, and Paul E. Klotman. “HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells..” J Acquir Immune Defic Syndr 42, no. 1 (May 2006): 1–11. https://doi.org/10.1097/01.qai.0000218353.60099.4f.
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  - Ross, Michael J., Matthew S. Wosnitzer, Michael D. Ross, Benedetta Granelli, G Luca Gusella, Mohammad Husain, Lewis Kaufman, et al. “Role of ubiquitin-like protein FAT10 in epithelial apoptosis in renal disease..” J Am Soc Nephrol 17, no. 4 (April 2006): 996–1004. https://doi.org/10.1681/ASN.2005070692.
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  - Dhawan, Darpun, Marla Keller, and Mary E. Klotman. “Topical microbicides: the time has come..” Aids Read 16, no. 3 (March 2006): 144–61.
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  - Fierer, Daniel S., and Mary E. Klotman. “Kidney and central nervous system as reservoirs of HIV infection..” Curr Opin Hiv Aids 1, no. 2 (March 2006): 115–20. https://doi.org/10.1097/01.COH.0000209581.88166.89.
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  - Zerhouni-Layachi, Bouchra, Mohammad Husain, Michael J. Ross, Daniele Marras, Masaaki Sunamoto, Xinyan Liu, Paul E. Klotman, and Mary E. Klotman. “Dual tropism of HIV-1 envelopes derived from renal tubular epithelial cells of patients with HIV-associated nephropathy..” Aids 20, no. 4 (February 28, 2006): 621–24. https://doi.org/10.1097/01.aids.0000210618.68083.8e.
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  - Wyatt, Christina M., Raymond R. Arons, Paul E. Klotman, and Mary E. Klotman. “Acute renal failure in hospitalized patients with HIV: risk factors and impact on in-hospital mortality..” Aids (London, England) 20, no. 4 (February 2006): 561–65. https://doi.org/10.1097/01.aids.0000210610.52836.07.
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  - Keller, Marla J., Bouchra Zerhouni-Layachi, Natalia Cheshenko, Minnie John, Kathleen Hogarty, Andrea Kasowitz, Cindy L. Goldberg, et al. “PRO 2000 gel inhibits HIV and herpes simplex virus infection following vaginal application: a double-blind placebo-controlled trial..” J Infect Dis 193, no. 1 (January 1, 2006): 27–35. https://doi.org/10.1086/498533.
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  - Husain, Mohammad, Vivette D. D’Agati, John Cijiang He, Mary E. Klotman, and Paul E. Klotman. “HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN..” Aids 19, no. 17 (November 18, 2005): 1975–80. https://doi.org/10.1097/01.aids.0000191918.42110.27.
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  - John, Minnie, Marla J. Keller, Ehsan H. Fam, Natalia Cheshenko, Kathleen Hogarty, Andrea Kasowitz, Sylvan Wallenstein, et al. “Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection..” J Infect Dis 192, no. 10 (November 15, 2005): 1731–40. https://doi.org/10.1086/497168.
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  - Scordi-Bello, Irini A., Arevik Mosoian, Cejiang He, Yiban Chen, Yang Cheng, Gary A. Jarvis, Marla J. Keller, et al. “Candidate sulfonated and sulfated topical microbicides: comparison of anti-human immunodeficiency virus activities and mechanisms of action..” Antimicrob Agents Chemother 49, no. 9 (September 2005): 3607–15. https://doi.org/10.1128/AAC.49.9.3607-3615.2005.
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  - Schwartz, Elissa J., Lynda A. Szczech, Michael J. Ross, Mary E. Klotman, Jonathan A. Winston, and Paul E. Klotman. “Highly active antiretroviral therapy and the epidemic of HIV+ end-stage renal disease..” J Am Soc Nephrol 16, no. 8 (August 2005): 2412–20. https://doi.org/10.1681/ASN.2005040340.
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  - Chang, Theresa L., Jesus Vargas, Armando DelPortillo, and Mary E. Klotman. “Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity..” The Journal of Clinical Investigation 115, no. 3 (March 2005): 765–73. https://doi.org/10.1172/JCI200521948.
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  - Chang, Theresa L., Jesus Vargas, Armando DelPortillo, and Mary E. Klotman. “Dual role of alpha-defensin-1 in anti-HIV-1 innate immunity..” J Clin Invest 115, no. 3 (March 2005): 765–73. https://doi.org/10.1172/JCI21948.
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  - Gillim-Ross, Laura, Andrea Cara, and Mary E. Klotman. “Nef expressed from human immunodeficiency virus type 1 extrachromosomal DNA downregulates CD4 on primary CD4+ T lymphocytes: implications for integrase inhibitors..” J Gen Virol 86, no. Pt 3 (March 2005): 765–71. https://doi.org/10.1099/vir.0.80570-0.
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  - Gillim-Ross, Laura, Andrea Cara, and Mary E. Klotman. “HIV-1 extrachromosomal 2-LTR circular DNA is long-lived in human macrophages..” Viral Immunol 18, no. 1 (2005): 190–96. https://doi.org/10.1089/vim.2005.18.190.
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  - Jing, Bingwen, Vaclav Janout, Betsy C. Herold, Mary E. Klotman, Taylor Heald, and Steven L. Regen. “Persulfated molecular umbrellas as anti-HIV and anti-HSV agents..” J Am Chem Soc 126, no. 49 (December 15, 2004): 15930–31. https://doi.org/10.1021/ja044400o.
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  - He, John Cijiang, Mohammad Husain, Masaaki Sunamoto, Vivette D. D’Agati, Mary E. Klotman, Ravi Iyengar, and Paul E. Klotman. “Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways..” The Journal of Clinical Investigation 114, no. 5 (September 2004): 643–51. https://doi.org/10.1172/JCI200421004.
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  - He, John Cijiang, Mohammad Husain, Masaaki Sunamoto, Vivette D. D’Agati, Mary E. Klotman, Ravi Iyengar, and Paul E. Klotman. “Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways..” J Clin Invest 114, no. 5 (September 2004): 643–51. https://doi.org/10.1172/JCI21004.
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  - Chang, Theresa L., and Mary E. Klotman. “Defensins: natural anti-HIV peptides..” Aids Rev 6, no. 3 (July 2004): 161–68.
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  - Cheshenko, Natalia, Marla J. Keller, Veronica MasCasullo, Gary A. Jarvis, Hui Cheng, Minnie John, Jin-Hua Li, et al. “Candidate topical microbicides bind herpes simplex virus glycoprotein B and prevent viral entry and cell-to-cell spread..” Antimicrob Agents Chemother 48, no. 6 (June 2004): 2025–36. https://doi.org/10.1128/AAC.48.6.2025-2036.2004.
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  - Winston, J. A., P. E. Klotman, and M. Klotman. “Renal Manifestations of HIV Infection,” April 8, 2004, 651–61. https://doi.org/10.1016/B978-012764051-8/50026-3.
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  - Vargas, J., G. L. Gusella, V. Najfeld, M. E. Klotman, and A. Cara. “Novel integrase-defective lentiviral episomal vectors for gene transfer..” Hum Gene Ther 15, no. 4 (April 2004): 361–72. https://doi.org/10.1089/104303404322959515.
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  - Ross, Michael D., Leslie A. Bruggeman, Basil Hanss, Masaaki Sunamoto, Daniele Marras, Mary E. Klotman, and Paul E. Klotman. “Podocan, a novel small leucine-rich repeat protein expressed in the sclerotic glomerular lesion of experimental HIV-associated nephropathy..” J Biol Chem 278, no. 35 (August 29, 2003): 33248–55. https://doi.org/10.1074/jbc.M301299200.
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  - Chang, Theresa Li-Yun, Fleur François, Arevik Mosoian, and Mary E. Klotman. “CAF-mediated human immunodeficiency virus (HIV) type 1 transcriptional inhibition is distinct from alpha-defensin-1 HIV inhibition..” J Virol 77, no. 12 (June 2003): 6777–84. https://doi.org/10.1128/jvi.77.12.6777-6784.2003.
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  - Hernandez, Paolo A., Robert J. Gorlin, John N. Lukens, Shoichiro Taniuchi, Joze Bohinjec, Fleur Francois, Mary E. Klotman, and George A. Diaz. “Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease..” Nat Genet 34, no. 1 (May 2003): 70–74. https://doi.org/10.1038/ng1149.
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  - Keller, M. J., M. E. Klotman, and B. C. Herold. “Development of topical microbicides for prevention of human immunodeficiency virus and herpes simplex virus..” Am J Reprod Immunol 49, no. 5 (May 2003): 279–84. https://doi.org/10.1034/j.1600-0897.2003.00044.x.
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  - Keller, Marla J., Mary E. Klotman, and Betsy C. Herold. “Rigorous pre-clinical evaluation of topical microbicides to prevent transmission of human immunodeficiency virus..” The Journal of Antimicrobial Chemotherapy 51, no. 5 (May 2003): 1099–1102. https://doi.org/10.1093/jac/dkg214.
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  - François, Fleur, and Mary E. Klotman. “Phosphatidylinositol 3-kinase regulates human immunodeficiency virus type 1 replication following viral entry in primary CD4+ T lymphocytes and macrophages..” Journal of Virology 77, no. 4 (February 2003): 2539–49. https://doi.org/10.1128/JVI.77.4.2539-2549.2003.
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  - Herold, B. C., I. Scordi-Bello, N. Cheshenko, D. Marcellino, M. Dzuzelewski, F. Francois, R. Morin, et al. “Mandelic acid condensation polymer: novel candidate microbicide for prevention of human immunodeficiency virus and herpes simplex virus entry..” J Virol 76, no. 22 (November 2002): 11236–44. https://doi.org/10.1128/jvi.76.22.11236-11244.2002.
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  - Husain, Mohammad, G Luca Gusella, Mary E. Klotman, Irwin H. Gelman, Michael D. Ross, Elissa J. Schwartz, Andrea Cara, and Paul E. Klotman. “HIV-1 Nef induces proliferation and anchorage-independent growth in podocytes..” J Am Soc Nephrol 13, no. 7 (July 2002): 1806–15. https://doi.org/10.1097/01.asn.0000019642.55998.69.
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  - Schwartz, Elissa J., Daniel S. Fierer, Avidan U. Neumann, Marla J. Keller, Valerie Parkas, David Y. Zhang, Mary E. Klotman, Jonathan A. Winston, and Paul E. Klotman. “HIV-1 dynamics in haemodialysis patients..” Aids 16, no. 9 (June 14, 2002): 1301–3. https://doi.org/10.1097/00002030-200206140-00019.
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  - Klotman, Paul, and Mary Klotman. “Editorial comment: renal insufficiency in HIV-infected patients may not always be HIVAN..” Aids Read 12, no. 6 (June 2002).
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  - Marras, Daniele, Leslie A. Bruggeman, Feng Gao, Nozomu Tanji, Mahesh M. Mansukhani, Andrea Cara, Michael D. Ross, et al. “Replication and compartmentalization of HIV-1 in kidney epithelium of patients with HIV-associated nephropathy..” Nat Med 8, no. 5 (May 2002): 522–26. https://doi.org/10.1038/nm0502-522.
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  - Gusella, G Luca, Elena Fedorova, Basil Hanss, Daniele Marras, Mary E. Klotman, and Paul E. Klotman. “Lentiviral gene transduction of kidney..” Hum Gene Ther 13, no. 3 (February 10, 2002): 407–14. https://doi.org/10.1089/10430340252792530.
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  - Chang, Theresa Li-Yun, Arevik Mosoian, Richard Pine, Mary E. Klotman, and John P. Moore. “A soluble factor(s) secreted from CD8(+) T lymphocytes inhibits human immunodeficiency virus type 1 replication through STAT1 activation..” Journal of Virology 76, no. 2 (January 2002): 569–81. https://doi.org/10.1128/JVI.76.2.569-581.2002.
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  - Gusella, G Luca, Elena Fedorova, Daniele Marras, Paul E. Klotman, and Mary E. Klotman. “In vivo gene transfer to kidney by lentiviral vector..” Kidney Int 61, no. 1 Suppl (January 2002): S32–36. https://doi.org/10.1046/j.1523-1755.2002.0610s1032.x.
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  - Stern, Aaron S., Mary E. Klotman, Yiannis A. Ioannou, Christopher R. Burrow, Patricia D. Wilson, Paul E. Klotman, and Michael S. Lipkowitz. “Polarity of alpha-galactosidase A uptake by renal tubule cells..” Kidney Int 61, no. 1 Suppl (January 2002): S52–55. https://doi.org/10.1046/j.1523-1755.2002.0610s1052.x.
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  - Huprikar, S. S., S. D. Datta, L. Lang, and M. E. Klotman. “Viral load and CD4 count as predictors of response to hepatitis B vaccine.” Clinical Infectious Diseases 33, no. 7 (October 1, 2001): 1153–1153.
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  - Schecter, A. D., A. B. Berman, L. Yi, A. Mosoian, C. M. McManus, J. W. Berman, M. E. Klotman, and M. B. Taubman. “HIV envelope gp120 activates human arterial smooth muscle cells..” Proc Natl Acad Sci U S A 98, no. 18 (August 28, 2001): 10142–47. https://doi.org/10.1073/pnas.181328798.
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  - Jones, S., and M. E. Klotman. “Impact of genotypic resistance testing on physician selection of antiretroviral therapy..” J Hum Virol 4, no. 4 (July 2001): 214–16.
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  - Winston, J. A., L. A. Bruggeman, M. D. Ross, J. Jacobson, L. Ross, V. D. D’Agati, P. E. Klotman, and M. E. Klotman. “Nephropathy and establishment of a renal reservoir of HIV type 1 during primary infection..” N Engl J Med 344, no. 26 (June 28, 2001): 1979–84. https://doi.org/10.1056/NEJM200106283442604.
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  - Schecter, A. D., A. B. Berman, L. Yi, J. W. Berman, M. E. Klotman, and M. B. Taubman. “Human immunodeficiency viral envelope protein, gp120, induces tissue factor activity in human arterial smooth muscle cells..” Arteriosclerosis Thrombosis and Vascular Biology 21, no. 4 (April 1, 2001): 690–690.
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  - Gillim, L., G. L. Gusella, J. Vargas, D. Marras, M. E. Klotman, and A. Cara. “Development of a novel screen for protease inhibitors..” Clin Diagn Lab Immunol 8, no. 2 (March 2001): 437–40. https://doi.org/10.1128/CDLI.8.2.437-440.2001.
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  - Bruggeman, L. A., M. D. Ross, N. Tanji, A. Cara, S. Dikman, R. E. Gordon, G. C. Burns, et al. “Renal epithelium is a previously unrecognized site of HIV-1 infection..” Journal of the American Society of Nephrology : Jasn 11, no. 11 (November 2000): 2079–87.
  - Jacobson, J. M., I. Lowy, C. V. Fletcher, T. J. O’Neill, D. N. Tran, T. J. Ketas, A. Trkola, et al. “Single-dose safety, pharmacology, and antiviral activity of the human immunodeficiency virus (HIV) type 1 entry inhibitor PRO 542 in HIV-infected adults..” J Infect Dis 182, no. 1 (July 2000): 326–29. https://doi.org/10.1086/315698.
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  - Jones, S., and M. E. Klotman. “Access to genotypic resistance testing alters physician selection of antiretroviral therapy..” Clinical Infectious Diseases 31, no. 1 (July 1, 2000): 275–275.
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  - Tellier, M. C., G. Greco, M. Klotman, A. Mosoian, A. Cara, W. Arap, E. Ruoslahti, R. Pasqualini, and L. M. Schnapp. “Superfibronectin, a multimeric form of fibronectin, increases HIV infection of primary CD4+ T lymphocytes..” J Immunol 164, no. 6 (March 15, 2000): 3236–45. https://doi.org/10.4049/jimmunol.164.6.3236.
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  - Mosoian, A., A. Teixeira, E. Caron, J. Piwoz, and M. E. Klotman. “CD8⁺ cell lines isolated from HIV-1-infected children have potent soluble HIV-1 inhibitory activity that differs from β-chemokines.” Viral Immunology 13, no. 4 (2000): 481–95.
  - Mosoian, A., A. Teixeira, E. Caron, J. Piwoz, and M. E. Klotman. “CD8+ cell lines isolated from HIV-1-infected children have potent soluble HIV-1 inhibitory activity that differs from beta-chemokines..” Viral Immunol 13, no. 4 (2000): 481–95. https://doi.org/10.1089/vim.2000.13.481.
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  - Lipkowitz, M. S., B. Hanss, N. Tulchin, P. D. Wilson, J. C. Langer, M. D. Ross, G. J. Kurtzman, P. E. Klotman, and M. E. Klotman. “Transduction of renal cells in vitro and in vivo by adeno-associated virus gene therapy vectors..” J Am Soc Nephrol 10, no. 9 (September 1999): 1908–15.
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  - Winston, J. A., M. E. Klotman, and P. E. Klotman. “HIV-associated nephropathy is a late, not early, manifestation of HIV-1 infection..” Kidney Int 55, no. 3 (March 1999): 1036–40. https://doi.org/10.1046/j.1523-1755.1999.0550031036.x.
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  - Klotman, M. “Potential role for G-protein coupled receptors in HIV-associated nephropathy..” Kidney Int 54, no. 6 (December 1998): 2243–44. https://doi.org/10.1038/4499992.
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  - Gelfand, J. M., D. Rudikoff, M. Lebwohl, and M. E. Klotman. “Effect of UV-B phototherapy on plasma HIV type 1 RNA viral level: a self-controlled prospective study..” Arch Dermatol 134, no. 8 (August 1998): 940–45. https://doi.org/10.1001/archderm.134.8.940.
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  - Gurtman, A., F. Borrego, and M. E. Klotman. “Management of antiretroviral therapy..” Semin Nephrol 18, no. 4 (July 1998): 459–80.
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  - Langer, J. C., M. E. Klotman, B. Hanss, N. Tulchin, L. A. Bruggeman, P. E. Klotman, and M. S. Lipkowitz. “Adeno-associated virus gene transfer into renal cells: potential for in vivo gene delivery..” Exp Nephrol 6, no. 3 (May 1998): 189–94.
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  - Rivadeneira, E. D., N. C. Popescu, D. B. Zimonjic, G. S. Cheng, P. J. Nelson, M. D. Ross, J. A. DiPaolo, and M. E. Klotman. “Sites of recombinant adeno-associated virus integration..” Int J Oncol 12, no. 4 (April 1998): 805–10. https://doi.org/10.3892/ijo.12.4.805.
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  - Klotman, M. E., and P. E. Klotman. “Seminars in nephrology.” Seminars in Nephrology 18, no. 4 (January 1, 1998): 371–72.
  - Snoeck, H. W., W. Tao, and M. E. Klotman. “Adeno-associated viral vectors: background and technical aspects..” Exp Nephrol 5, no. 6 (November 1997): 514–20.
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  - Cereseto, A., Z. Berneman, I. Koralnik, J. Vaughn, G. Franchini, and M. E. Klotman. “Differential expression of alternatively spliced pX mRNAs in HTLV-I-infected cell lines..” Leukemia 11, no. 6 (June 1997): 866–70. https://doi.org/10.1038/sj.leu.2400665.
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  - Lipkowitz, M. S., M. E. Klotman, L. A. Bruggeman, P. Nicklin, B. Hanss, J. Rappaport, and P. E. Klotman. “Molecular therapy for renal diseases..” Am J Kidney Dis 28, no. 4 (October 1996): 475–92. https://doi.org/10.1016/s0272-6386(96)90457-6.
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  - Cereseto, A., F. Diella, J. C. Mulloy, A. Cara, P. Michieli, R. Grassmann, G. Franchini, and M. E. Klotman. “p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells..” Blood 88, no. 5 (September 1, 1996): 1551–60.
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  - Bruggeman, L. A., M. M. Thomson, P. J. Nelson, J. B. Kopp, J. Rappaport, P. E. Klotman, and M. E. Klotman. “Patterns of HIV-1 mRNA expression in transgenic mice are tissue-dependent..” Virology 202, no. 2 (August 1, 1994): 940–48. https://doi.org/10.1006/viro.1994.1416.
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  - Santoro, T. J., J. L. Bryant, J. Pellicoro, M. E. Klotman, J. B. Kopp, L. A. Bruggeman, R. R. Franks, A. L. Notkins, and P. E. Klotman. “Growth failure and AIDS-like cachexia syndrome in HIV-1 transgenic mice..” Virology 201, no. 1 (May 15, 1994): 147–51. https://doi.org/10.1006/viro.1994.1276.
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  - Gallo, R. C., and M. E. Klotman. “1993 Annual Meeting of the Laboratory of Tumor Cell Biology: Introduction.” Aids Research and Human Retroviruses 10, no. SUPPL. 1 (January 1, 1994).
  - Dhawan, S., B. S. Weeks, F. Abbasi, H. R. Gralnick, A. L. Notkins, M. E. Klotman, K. M. Yamada, and P. E. Klotman. “Increased expression of alpha 4 beta 1 and alpha 5 beta 1 integrins on HTLV-I-infected lymphocytes..” Virology 197, no. 2 (December 1993): 778–81. https://doi.org/10.1006/viro.1993.1656.
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  - Li, G., J. Lisziewicz, D. Sun, G. Zon, S. Daefler, F. Wong-Staal, R. C. Gallo, and M. E. Klotman. “Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element..” J Virol 67, no. 11 (November 1993): 6882–88.
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  - Weeks, B. S., M. E. Klotman, E. Holloway, W. G. Stetler-Stevenson, H. K. Kleinman, and P. E. Klotman. “HIV-1 infection stimulates T cell invasiveness and synthesis of the 92-kDa type IV collagenase..” Aids Res Hum Retroviruses 9, no. 6 (June 1993): 513–18. https://doi.org/10.1089/aid.1993.9.513.
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  - Weeks, B. S., K. Desai, P. M. Loewenstein, M. E. Klotman, P. E. Klotman, M. Green, and H. K. Kleinman. “Identification of a novel cell attachment domain in the HIV-1 Tat protein and its 90-kDa cell surface binding protein..” The Journal of Biological Chemistry 268, no. 7 (March 1993): 5279–84.
  - Lisziewicz, J., D. Sun, M. Klotman, S. Agrawal, P. Zamecnik, and R. Gallo. “Specific inhibition of human immunodeficiency virus type 1 replication by antisense oligonucleotides: an in vitro model for treatment..” Proc Natl Acad Sci U S A 89, no. 23 (December 1, 1992): 11209–13. https://doi.org/10.1073/pnas.89.23.11209.
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  - Koralnik, I. J., A. Gessain, M. E. Klotman, A. Lo Monico, Z. N. Berneman, and G. Franchini. “Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I..” Proc Natl Acad Sci U S A 89, no. 18 (September 15, 1992): 8813–17. https://doi.org/10.1073/pnas.89.18.8813.
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  - Perfect, J. R., M. E. Klotman, C. C. Gilbert, D. D. Crawford, G. L. Rosner, K. A. Wright, and W. P. Peters. “Prophylactic intravenous amphotericin B in neutropenic autologous bone marrow transplant recipients..” J Infect Dis 165, no. 5 (May 1992): 891–97. https://doi.org/10.1093/infdis/165.5.891.
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  - Berneman, Z. N., R. B. Gartenhaus, M. S. Reitz, W. A. Blattner, A. Manns, B. Hanchard, O. Ikehara, R. C. Gallo, and M. E. Klotman. “Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leukemia/lymphoma and healthy carriers..” Proc Natl Acad Sci U S A 89, no. 7 (April 1, 1992): 3005–9. https://doi.org/10.1073/pnas.89.7.3005.
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  - Kopp, J. B., M. E. Klotman, S. H. Adler, L. A. Bruggeman, P. Dickie, N. J. Marinos, M. Eckhaus, J. L. Bryant, A. L. Notkins, and P. E. Klotman. “Progressive glomerulosclerosis and enhanced renal accumulation of basement membrane components in mice transgenic for human immunodeficiency virus type 1 genes..” Proc Natl Acad Sci U S A 89, no. 5 (March 1, 1992): 1577–81. https://doi.org/10.1073/pnas.89.5.1577.
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  - Klotman, M. E., S. Y. Kim, A. Buchbinder, A. DeRossi, D. Baltimore, and F. Wong-Staal. “Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes..” Proc Natl Acad Sci U S A 89, no. 3 (February 1, 1992). https://doi.org/10.1073/pnas.89.3.1148b.
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  - Berneman, Z. N., R. B. Gartenhaus, M. S. Reitz, M. E. Klotman, and R. C. Gallo. “cDNA sequencing confirms HTLV-I expression in adult T-cell leukemia/lymphoma and different sequence variations in vivo and in vitro..” Leukemia 6 Suppl 3 (1992): 67S-71S.
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  - Klotman, M. E., S. Kim, A. Buchbinder, A. DeRossi, D. Baltimore, and F. Wong-Staal. “Erratum: Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes (Proc. Natl. Acad. Sci. USA (June 1991) 88 (5011-5015)).” Proceedings of the National Academy of Sciences of the United States of America 89, no. 3 (January 1, 1992).
  - Gartenhaus, R. B., F. Wong-Staal, and M. E. Klotman. “The promoter of human T-cell leukemia virus type-I is repressed by the immediate-early gene region of human cytomegalovirus in primary blood lymphocytes..” Blood 78, no. 11 (December 1, 1991): 2956–61.
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  - Weeks, B. S., M. E. Klotman, S. Dhawan, M. Kibbey, J. Rappaport, H. K. Kleinman, K. M. Yamada, and P. E. Klotman. “HIV-1 infection of human T lymphocytes results in enhanced alpha 5 beta 1 integrin expression..” J Cell Biol 114, no. 4 (August 1991): 847–53. https://doi.org/10.1083/jcb.114.4.847.
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  - Klotman, M. E., S. Kim, A. Buchbinder, A. DeRossi, D. Baltimore, and F. Wong-Staal. “Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes..” Proc Natl Acad Sci U S A 88, no. 11 (June 1, 1991): 5011–15. https://doi.org/10.1073/pnas.88.11.5011.
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  - Daefler, S., M. E. Klotman, and F. Wong-Staal. “Trans-activating rev protein of the human immunodeficiency virus 1 interacts directly and specifically with its target RNA..” Proc Natl Acad Sci U S A 87, no. 12 (June 1990): 4571–75. https://doi.org/10.1073/pnas.87.12.4571.
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  - Shaunak, S., R. E. Albright, M. E. Klotman, S. C. Henry, J. A. Bartlett, and J. D. Hamilton. “Amplification of HIV-1 provirus from cerebrospinal fluid and its correlation with neurologic disease..” J Infect Dis 161, no. 6 (June 1990): 1068–72. https://doi.org/10.1093/infdis/161.6.1068.
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  - Sadaie, M. R., E. Tschachler, K. Valerie, M. Rosenberg, B. K. Felber, G. N. Pavlakis, M. E. Klotman, and F. Wong-Staal. “Activation of tat-defective human immunodeficiency virus by ultraviolet light..” The New Biologist 2, no. 5 (May 1990): 479–86.
  - Klotman, M. E., S. C. Henry, R. C. Greene, P. C. Brazy, P. E. Klotman, and J. D. Hamilton. “Detection of mouse cytomegalovirus nucleic acid in latently infected mice by in vitro enzymatic amplification..” J Infect Dis 161, no. 2 (February 1990): 220–25. https://doi.org/10.1093/infdis/161.2.220.
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  - Kim, J. H., R. A. Cooper, K. E. Welty-Wolf, L. J. Harrell, P. Zwadyk, and M. E. Klotman. “Pseudomonas putrefaciens bacteremia..” Rev Infect Dis 11, no. 1 (January 1989): 97–104.
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  - Peters, W. P., A. Stuart, M. Klotman, C. Gilbert, R. B. Jones, E. J. Shpall, J. Gockerman, R. C. Bast, and J. O. Moore. “High-dose combination cyclophosphamide, cisplatin, and melphalan with autologous bone marrow support. A clinical and pharmacologic study..” Cancer Chemother Pharmacol 23, no. 6 (1989): 377–83. https://doi.org/10.1007/bf00435840.
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  - Schmader, K. E., C. M. van der Horst, and M. E. Klotman. “Epstein-Barr virus and the elderly host..” Rev Infect Dis 11, no. 1 (January 1989): 64–73. https://doi.org/10.1093/clinids/11.1.64.
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  - Buchbinder, A., S. F. Josephs, D. Ablashi, S. Z. Salahuddin, M. E. Klotman, M. Manak, G. R. Krueger, F. Wong-Staal, and R. C. Gallo. “Polymerase chain reaction amplification and in situ hybridization for the detection of human B-lymphotropic virus..” J Virol Methods 21, no. 1–4 (September 1988): 191–97. https://doi.org/10.1016/0166-0934(88)90065-1.
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  - Klotman, M. E., S. C. Henry, and J. D. Hamilton. “Determinants of the source of cytomegalovirus in murine renal allograft recipients..” Transplantation 44, no. 5 (November 1987): 636–39. https://doi.org/10.1097/00007890-198711000-00008.
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  - Klotman, M. E., and J. D. Hamilton. “Cytomegalovirus pneumonia..” Semin Respir Infect 2, no. 2 (June 1987): 95–103.
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  - Klotman, M. E., D. Starnes, and J. D. Hamilton. “The source of murine cytomegalovirus in mice receiving kidney allografts..” J Infect Dis 152, no. 6 (December 1985): 1192–96. https://doi.org/10.1093/infdis/152.6.1192.
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  - Klotman, M. E. “Laboratory detection of urinary tract infections.” Kidney 18, no. 1 (January 1, 1985): 1–4.
- Conference Papers
  - Blasi, M., D. Negri, S. Santra, R. Parks, X. Shen, G. Tomaras, S. Permar, et al. “A Single Immunization with Integrase Defective Lentiviral Vector Expressing gp140 Induces Persistent and Functional Immune Response in Rhesus Monkeys.” In Aids Research and Human Retroviruses, 29:A161–A161. MARY ANN LIEBERT, INC, 2013.
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  - Tuyama, Ana C., Feng Hong, Alison D. Schecter, Arevik Mosoian, Benjamin K. Chen, Ping Chen, Mary E. Klotman, and Meena B. Bansal. “HIV entry and replication stellate cells promotes cellular activation and fibrogenesis: Implications for hepatic fibrosis in HIV/HCV co-infection.” In Hepatology, 46:291A-291A. JOHN WILEY & SONS INC, 2007.
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  - Zerhouni-Layachi, B., D. Marras, F. Francois, P. E. Klotman, and M. E. Klotman. “Phenotypic characterization of HIV-1 envelopes derived from patients with HIVAN..” In Journal of the American Society of Nephrology, 14:154A-154A. LIPPINCOTT WILLIAMS & WILKINS, 2003.
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  - Cara, A., J. Vargas, M. Keller, S. Jones, A. Mosoian, A. Gurtman, A. Cohen, et al. “Circular viral DNA and anomalous junction sequence in PBMC of HIV-infected individuals with no detectable plasma HIV RNA..” In Virology, 292:1–5, 2002. https://doi.org/10.1006/viro.2001.1243.
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Teaching & Mentoring
Recent Courses
- PATHOL 793: Research Independent Study 2019

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