Scholars@Duke
Masayuki Kuraoka

Masayuki Kuraoka

Associate Research Professor of Integrative Immunobiology
Integrative Immunobiology
masayuki.kuraoka@duke.edu
Box 3010 Med Ctr, Durham, NC 27710
27 Alexandria Way, Room 2239, Building 3, Durham, NC 27703

Selected Publications

Tracing Self-Reactive B Cells in Normal Mice.

Journal Article J Immunol · July 1, 2020 BCR transgenic mice dominate studies of B cell tolerance; consequently, tolerance in normal mice expressing diverse sets of autoreactive B cells is poorly characterized. We have used single B cell cultures to trace self-reactivity in BCR repertoires across ... Full text Link to item Cite

Influenza Antigen Engineering Focuses Immune Responses to a Subdominant but Broadly Protective Viral Epitope.

Journal Article Cell Host Microbe · June 12, 2019 Viral glycoproteins are under constant immune surveillance by a host's adaptive immune responses. Antigenic variation including glycan introduction or removal is among the mechanisms viruses have evolved to escape host immunity. Understanding how glycosyla ... Full text Link to item Cite

HIV-1 Consensus Envelope-Induced Broadly Binding Antibodies.

Journal Article AIDS Res Hum Retroviruses · August 2017 Antibodies that cross-react with multiple HIV-1 envelopes (Envs) are useful reagents for characterizing Env proteins and for soluble Env capture and purification assays. We previously reported 10 murine monoclonal antibodies induced by group M consensus En ... Full text Link to item Cite

Complex Antigens Drive Permissive Clonal Selection in Germinal Centers.

Journal Article Immunity · March 15, 2016 Germinal center (GC) B cells evolve toward increased affinity by a Darwinian process that has been studied primarily in genetically restricted, hapten-specific responses. We explored the population dynamics of genetically diverse GC responses to two comple ... Full text Link to item Cite

The human fetal lymphocyte lineage: identification by CD27 and LIN28B expression in B cell progenitors.

Journal Article J Leukoc Biol · November 2013 CD27, a member of the TNFR superfamily, is used to identify human memory B cells. Nonetheless, CD27(+) B cells are present in patients with HIGM1 syndrome who are unable to generate GCs or memory B cells. CD27(+)IgD(+) fetal B cells are present in umbilica ... Full text Link to item Cite

Activation-induced cytidine deaminase mediates central tolerance in B cells.

Journal Article Proc Natl Acad Sci U S A · July 12, 2011 The Aicda gene product, activation-induced cytidine deaminase (AID), initiates somatic hypermutation, class-switch recombination, and gene conversion of Ig genes by the deamination of deoxycytidine, followed by error-prone mismatch- or base-excision DNA re ... Full text Link to item Cite

Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome.

Journal Article J Immunol · September 1, 2009 Somatic hypermutation normally occurs as a consequence of the expression of activation-induced cytidine deaminase (AID) by Ag-activated, mature B cells during T cell-dependent germinal center responses. Nonetheless, despite their inability to express CD154 ... Full text Link to item Cite