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Mashael Al-Hegelan

Associate Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
108 Hanes Hse, Box 102349, Durham, NC 27710
108 Hanes Hse, Box 102349, Durham, NC 27710

Selected Publications

Mobile Application-Based Communication Facilitation Platform for Family Members of Critically Ill Patients: A Randomized Clinical Trial.

Journal Article JAMA Netw Open · January 2, 2024 IMPORTANCE: Unmet and racially disparate palliative care needs are common in intensive care unit (ICU) settings. OBJECTIVE: To test the effect of a primary palliative care intervention vs usual care control both overall and by family member race. DESIGN, S ... Full text Link to item Cite

Phenobarbital versus benzodiazepines in alcohol withdrawal syndrome.

Journal Article Neuropsychopharmacol Rep · December 2023 AIM: Phenobarbital, a long-acting barbiturate, presents an alternative to conventional benzodiazepine treatment for alcohol withdrawal syndrome (AWS). Currently, existing research offers only modest guidance on the safety and effectiveness of phenobarbital ... Full text Link to item Cite

Trajectories of Palliative Care Needs in the ICU and Long-Term Psychological Distress Symptoms.

Journal Article Crit Care Med · January 1, 2023 OBJECTIVES: While palliative care needs are assumed to improve during ICU care, few empiric data exist on need trajectories or their impact on long-term outcomes. We aimed to describe trajectories of palliative care needs during ICU care and to determine i ... Full text Link to item Cite

Palliative care phenotypes among critically ill patients and family members: intensive care unit prospective cohort study.

Journal Article BMJ Support Palliat Care · September 27, 2022 OBJECTIVE: Because the heterogeneity of patients in intensive care units (ICUs) and family members represents a challenge to palliative care delivery, we aimed to determine if distinct phenotypes of palliative care needs exist. METHODS: Prospective cohort ... Full text Link to item Cite

Assessment of Clinical Palliative Care Trigger Status vs Actual Needs Among Critically Ill Patients and Their Family Members.

Journal Article JAMA Netw Open · January 4, 2022 IMPORTANCE: Palliative care consultations in intensive care units (ICUs) are increasingly prompted by clinical characteristics associated with mortality or resource utilization. However, it is not known whether these triggers reflect actual palliative care ... Full text Link to item Cite

Improving racial disparities in unmet palliative care needs among intensive care unit family members with a needs-targeted app intervention: The ICUconnect randomized clinical trial.

Journal Article Contemp Clin Trials · April 2021 INTRODUCTION: The technologies used to treat the millions who receive care in intensive care unit (ICUs) each year have steadily advanced. However, the quality of ICU-based communication has remained suboptimal, particularly concerning for Black patients a ... Full text Link to item Cite

Palliative Care Triggers vs Actual Unmet Needs Among ICU Patients and Family Members


Operationalizing needs-focused palliative care for older adults in intensive care units: Design of and rationale for the PCplanner randomized clinical trial.

Journal Article Contemp Clin Trials · November 2020 INTRODUCTION: The number of older adults who receive life support in an intensive care unit (ICU), now 2 million per year, is increasing while survival remains unchanged. Because the quality of ICU-based palliative care is highly variable, we developed a m ... Full text Link to item Cite

Development and validation of an electronic medical record (EMR)-based computed phenotype of HIV-1 infection.

Journal Article J Am Med Inform Assoc · February 1, 2018 BACKGROUND: Electronic medical record (EMR) computed algorithms allow investigators to screen thousands of patient records to identify specific disease cases. No computed algorithms have been developed to detect all cases of human immunodeficiency virus (H ... Full text Link to item Cite

Angiotensin II for the Treatment of Vasodilatory Shock.

Journal Article N Engl J Med · August 3, 2017 BACKGROUND: Vasodilatory shock that does not respond to high-dose vasopressors is associated with high mortality. We investigated the effectiveness of angiotensin II for the treatment of patients with this condition. METHODS: We randomly assigned patients ... Full text Link to item Cite

Novel modes of mechanical ventilation.

Journal Article Semin Respir Crit Care Med · August 2013 The overarching goal of positive pressure mechanical ventilation is to provide adequate gas exchange support while not causing harm. Indeed, positive pressure mechanical ventilators are only support technologies, not therapeutic technologies. As such they ... Full text Link to item Cite

Adverse effects of outdoor air pollution

Journal Article Clinical Pulmonary Medicine · January 1, 2012 Despite tighter regulation in recent years, epidemiologic studies continue to show associations between adverse health effects and outdoor air pollution. These adverse effects occur at levels of pollutants much lower than those encountered in earlier air p ... Full text Cite

Extracorporeal membrane oxygenation for severe refractory respiratory failure secondary to 2009 H1N1 influenza A.

Journal Article Respir Care · July 2011 BACKGROUND: Respiratory failure and acute respiratory distress syndrome secondary to H1N1 influenza infection is a source of substantial morbidity and mortality, having caused over 265,000 hospitalizations in the United States in 2009. During the H1N1 pand ... Full text Link to item Cite

Ambient ozone and pulmonary innate immunity.

Journal Article Immunol Res · April 2011 Ambient ozone is a criteria air pollutant that impacts both human morbidity and mortality. The effect of ozone inhalation includes both toxicity to lung tissue and alteration of the host immunologic response. The innate immune system facilitates immediate ... Full text Link to item Cite

Leptotrichia endocarditis: report of two cases from the International Collaboration on Endocarditis (ICE) database and review of previous cases.

Journal Article Eur J Clin Microbiol Infect Dis · February 2008 Leptotrichia species typically colonize the oral cavity and genitourinary tract. We report the first two cases of endocarditis secondary to L. goodfellowii sp. nov. Both cases were identified using 16S rRNA gene sequencing. Review of the English literature ... Full text Link to item Cite

Non-HACEK gram-negative bacillus endocarditis.

Journal Article Ann Intern Med · December 18, 2007 BACKGROUND: Infective endocarditis caused by non-HACEK (species other than Haemophilus species, Actinobacillus actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, or Kingella species) gram-negative bacilli is rare, is poorly characterized, ... Full text Link to item Cite