Scholars@Duke
Janice Munn Massey

Janice Munn Massey

Professor of Neurology
Neurology, Neuromuscular Disease
masse005@mc.duke.edu
Duke Box 3403, Durham, NC 27710
1255 Hosp South, Duke South Clini 1L, Room 1255, Durham, NC 27710

Featured Works

Certification in neuromuscular medicine: a new neurologic subspecialty.

Journal article Neurology · April 3, 2007 Featured Publication Information is provided concerning the new subspecialty certificate in neuromuscular medicine of the American Board of Psychiatry and Neurology and the eligibility requirements for such certification of practicing neurologists and child neurologists. The A ... Full text Link to item Cite

Peripheral neuropathy in Krabbe disease: electrodiagnostic findings.

Journal article Neurology · July 25, 2006 Featured Publication BACKGROUND: Krabbe disease (KD) is associated with marked central and peripheral demyelination and nerve conduction studies (NCS) typically show a mixed sensorimotor demyelinating peripheral neuropathy (PN). OBJECTIVES: To further characterize the PN in a ... Full text Link to item Cite

Peripheral neuropathy in Krabbe disease: effect of hematopoietic stem cell transplantation.

Journal article Neurology · July 25, 2006 Featured Publication BACKGROUND: Hematopoietic stem cell transplantation (HSCT) may slow the progression of Krabbe disease (KD) if performed early in the disease. The authors' studies indicate that more than 90% of patients with KD have severe abnormalities in peripheral nerve ... Full text Link to item Cite

MuSK-antibody positive myasthenia gravis: clinical and electrodiagnostic patterns.

Journal article Clin Neurophysiol · September 2005 Featured Publication OBJECTIVE: To examine the clinical manifestations and patterns of electromyographic abnormalities in MuSK-Ab positive myasthenia gravis. METHODS: The clinical evaluations and electrodiagnostic testing results of 20 MuSK-Ab positive myasthenia gravis patien ... Full text Link to item Cite

Autoimmune Myasthenia Gravis: Recommendations for Treatment and Immunologic Modulation.

Journal article Curr Treat Options Neurol · January 2005 Featured Publication Treatment for myasthenia gravis should be individualized to each patient based on the clinical characteristics of myasthenia including the distribution, duration, and severity of weakness and resulting functional impairment; the risks for treatment complic ... Full text Link to item Cite

Myasthenia gravis and pregnancy.

Journal article Neurol Clin · November 2004 Featured Publication Treatment considerations for women who have MG and are of childbearing age are complicated. When possible, before pregnancy, establishing a plan for therapy is ideal, recognizing the potential concerns for the patient and the fetus. Decisions about treatme ... Full text Link to item Cite

Mycophenolate mofetil for myasthenia gravis: an analysis of efficacy, safety, and tolerability.

Journal article Neurology · November 25, 2003 Featured Publication The authors report a retrospective analysis of the use of mycophenolate mofetil (MyM) in 85 patients with autoimmune myasthenia gravis. The Myasthenia Gravis Foundation of America (MGFA) postintervention status (PIS) was used to characterize the treatment ... Full text Link to item Cite

Clinical aspects of MuSK antibody positive seronegative MG.

Journal article Neurology · June 24, 2003 Featured Publication Serum antibodies to muscle-specific receptor tyrosine kinase were detected in 12 of 32 patients with generalized seronegative MG. All were women, with onset between ages 21 and 59 years. Seven had prominent neck, shoulder, or respiratory muscle weakness an ... Full text Link to item Cite

Mycophenolate mofetil for myasthenia gravis: an open-label pilot study.

Journal article Neurology · January 9, 2001 Featured Publication In an open-label study, 12 patients with refractory MG or who were taking only corticosteroids and required additional immunosuppression received mycophenolate mofetil 1 g twice daily for 6 months. A reduction of three points in a quantified MG score and t ... Full text Link to item Cite

Retrospective analysis of the use of cyclosporine in myasthenia gravis.

Journal article Neurology · August 8, 2000 Featured Publication The authors reviewed the records of patients with myasthenia gravis who took cyclosporine for at least 6 months between November 1987 and January 1999. Of 57 patients who took cyclosporine for an average of 3.5 years, 55 (96%) had clinical improvement. The ... Full text Link to item Cite

A randomized trial of 3,4-diaminopyridine in Lambert-Eaton myasthenic syndrome.

Journal article Neurology · February 8, 2000 Featured Publication OBJECTIVES: The authors report the results of a prospective, placebo-controlled, randomized study to evaluate the effectiveness of 3,4-diaminopyridine (DAP) in patients with Lambert-Eaton myasthenic syndrome (LEMS) and to determine the acute and long-term ... Full text Link to item Cite

Acquired myasthenia gravis.

Journal article Neurol Clin · August 1997 Featured Publication Myasthenia gravis, an antibody-mediated disorder of neuromuscular transmission that produces clinical weakness, may be ocular or generalized. Clinical diagnostic evaluation may be supplemented by electrophysiologic studies and antibody testing. Therapeutic ... Full text Link to item Cite

The electrodiagnosis of myasthenia gravis and the Lambert-Eaton myasthenic syndrome.

Journal article Neurol Clin · May 1994 Featured Publication Electrodiagnostic studies are valuable in confirming the diagnosis of a disorder of neuromuscular transmission. They are used to distinguish presynaptic and postsynaptic abnormalities. These studies provide an objective measure of the severity of the illne ... Link to item Cite

Myotonic dystrophy.

Journal article Semin Neurol · September 1991 Featured Publication Full text Link to item Cite

Electromyography in disorders of neuromuscular transmission.

Journal article Semin Neurol · March 1990 Featured Publication Electrophysiologic tests in neuromuscular transmission disorders are valuable aids in the clinical assessment of patients with suspected disease. The techniques of RNS and SFEMG are most reliable when the electromyographer is aware of their pitfalls and wh ... Full text Link to item Cite

Vascular headache from extracranial venous malformation.

Journal article Headache · October 1989 Featured Publication Headache associated with intracranial venous anomalies is well described but headache associated with extracranial venous malformation previously has not been recognized. A case of extracranial venous malformation producing vascular headache is presented. ... Full text Link to item Cite

Moyamoya disease associated with polycystic kidney disease and eosinophilic granuloma.

Journal article Stroke · August 1989 Featured Publication Moyamoya disease has been associated with renal artery stenosis, cerebral hemorrhage, and multiple cranial traumas. We report a unique case of moyamoya disease associated with polycystic kidney disease and eosinophilic granuloma. Although the etiology of m ... Full text Link to item Cite

Management of facial spasm with Clostridium botulinum toxin.

Journal article Arch Otolaryngol Head Neck Surg · July 1989 Featured Publication Full text Link to item Cite

Evaluation of an automatic method of measuring features of motor unit action potentials.

Journal article Muscle Nerve · February 1989 Featured Publication This study was performed to evaluate an automatic method of motor unit action potential (MUAP) analysis developed in our laboratory. MUAPs were recorded from the biceps brachii muscle of 68 normal subjects and 122 patients with nerve or muscle disease. The ... Full text Link to item Cite

Automatic analysis of the electromyographic interference pattern using the turns: amplitude ratio.

Journal article Electroencephalogr Clin Neurophysiol · December 1988 Featured Publication This study was performed to compare different techniques of analyzing the electromyographic interference pattern (IP). Recordings were made from the biceps muscle with a concentric needle electrode at different sites and at different constant levels of vol ... Full text Link to item Cite

Single fiber electromyography in chronic progressive external ophthalmoplegia.

Journal article Muscle Nerve · May 1987 Featured Publication We have reviewed the electromyographic (EMG) studies of 17 patients with chronic progressive external ophthalmoplegia (CPEO). In 13 of 17 patients, conventional concentric needle EMG demonstrated a "myopathic" pattern, usually predominating in the shoulder ... Full text Link to item Cite

Quantitative electromyography after poliomyelitis.

Journal article Birth Defects Orig Artic Ser · 1987 Featured Publication Link to item Cite