Scholars@Duke
Joseph P. Mathew

Joseph P. Mathew

Jerry Reves, M.D. Distinguished Professor of Cardiac Anesthesiology
Anesthesiology, Cardiothoracic
joseph.mathew@duke.edu
Box 3094 Med Ctr, Durham, NC 27710
2301 Erwin Road, 5692 HAFS Building, Durham, NC 27710

Featured Works

Transcerebral platelet activation after aortic cross-clamp release is linked to neurocognitive decline.

Journal article Ann Thorac Surg · May 2006 Featured Publication BACKGROUND: Neurocognitive decline after cardiac surgery requiring cardiopulmonary bypass (CPB) may be caused in part by highly prothrombotic atheroemboli to the brain; the source of these emboli is likely the ascending aorta and aortic arch. We examined t ... Full text Link to item Cite

Preliminary report of the effects of complement suppression with pexelizumab on neurocognitive decline after coronary artery bypass graft surgery.

Journal article Stroke · October 2004 Featured Publication BACKGROUND AND PURPOSE: Pharmacological modulation of complement activation recently has been postulated as a therapeutic target in the treatment of neurological injury. We hypothesized that pexelizumab, a humanized scFv monoclonal antibody directed agains ... Full text Link to item Cite

A multicenter risk index for atrial fibrillation after cardiac surgery.

Journal article JAMA · April 14, 2004 Featured Publication CONTEXT: Atrial fibrillation is a common, but potentially preventable, complication following coronary artery bypass graft (CABG) surgery. OBJECTIVES: To assess the nature and consequences of atrial fibrillation after CABG surgery and to develop a comprehe ... Full text Link to item Cite

Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery.

Journal article Stroke · February 2003 Featured Publication BACKGROUND AND PURPOSE: Although coronary artery bypass graft surgery (CABG) improves the quality of life and functional capacity for numerous patients, many also exhibit impairment in cognitive function immediately after surgery. Although the etiology of ... Full text Link to item Cite

Atrial fibrillation following coronary artery bypass graft surgery: predictors, outcomes, and resource utilization. MultiCenter Study of Perioperative Ischemia Research Group.

Journal article JAMA · July 24, 1996 Featured Publication OBJECTIVE: To determine the incidence, predictors, and cost of atrial fibrillation and flutter (AFIB) following coronary artery bypass graft (CABG) surgery. DESIGN: Prospective observational study (MultiCenter Study of Perioperative Ischemia). SETTING: Twe ... Link to item Cite