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Hiroaki Matsunami

Professor of Molecular Genetics and Microbiology
Molecular Genetics and Microbiology
Duke Box 3054, Durham, NC 27710
264 CARL Bldg, Durham, NC 27710

Featured Works


Taste and pheromone perception in mammals and flies.

Journal article Genome Biol · 2003 Featured Publication The olfactory systems of insects and mammals have analogous anatomical features and use similar molecular logic for olfactory coding. The molecular underpinnings of the chemosensory systems that detect taste and pheromone cues have only recently been chara ... Full text Link to item Cite

Receptors for bitter and sweet taste.

Journal article Curr Opin Neurobiol · August 2002 Featured Publication The identification of two families of receptors, T1Rs and T2Rs, for sweet and bitter taste stimuli has opened the door to understanding some of the basic mechanisms underlying taste transduction in mammals. Studies of the functions of these receptors and t ... Full text Link to item Cite

A candidate taste receptor gene near a sweet taste locus.

Journal article Nat Neurosci · May 2001 Featured Publication The mechanisms underlying sweet taste in mammals have been elusive. Although numerous studies have implicated G proteins in sweet taste detection, the expected G protein-coupled receptors have not been found. Here we describe a candidate taste receptor gen ... Full text Link to item Cite

A family of candidate taste receptors in human and mouse.

Journal article Nature · April 6, 2000 Featured Publication The gustatory system of mammals can sense four basic taste qualities, bitter, sweet, salty and sour, as well as umami, the taste of glutamate. Previous studies suggested that the detection of bitter and sweet tastants by taste receptor cells in the mouth i ... Full text Link to item Cite

A multigene family encoding a diverse array of putative pheromone receptors in mammals.

Journal article Cell · August 22, 1997 Featured Publication The vomeronasal organ of mammals is an olfactory sensory structure that detects pheromones. It contains two subsets of sensory neurons that differentially express G alpha(o) and G alpha(i2). By comparing gene expression in single neurons, we identified a n ... Full text Link to item Cite

Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion.

Journal article Dev Biol · December 1995 Featured Publication We found that R-cadherin, a Ca2(+)-dependent cell--cell adhesion molecule, is expressed in restricted regions of the mouse fetal brain, as was found for E-cadherin previously. R-cadherin delineated a subset of alar domains within forebrain neuromeres and c ... Full text Link to item Cite