Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Michigan at Ann Arbor 2005
• 

  Leadership & Clinical Positions at Duke

  • Assistant Dean for Basic Science Education, Duke University School of Medicine
• 

  Academic Positions Outside Duke

  • Lecturer, University of Michigan Medical School. 2005 - 2019
• Expertise
• 

  Subject Headings

  • Aorta
  • Basic Helix-Loop-Helix Transcription Factors
  • Biological Markers
  • Brain-Derived Neurotrophic Factor
  • Cell Differentiation
  • Cell Lineage
  • Cell Proliferation
  • Cells, Cultured
  • Chick Embryo
  • Cochlear Nerve
  • Coronary Vessels
  • Deafness
  • Doxycycline
  • Embryo, Mammalian
  • Embryonic Stem Cells
  • Flow Cytometry
  • Gene Expression
  • Gene Expression Profiling
  • Gene Transfer Techniques
  • Genes, Reporter
  • Genetic Techniques
  • Glial Cell Line-Derived Neurotrophic Factor
  • Glutamic Acid
  • Green Fluorescent Proteins
  • Growth Substances
  • Guinea Pigs
  • Humans
  • Immunohistochemistry
  • Luminescent Proteins
  • Mice
  • Microscopy, Electron
  • Models, Genetic
  • Molecular Sequence Data
  • Neovascularization, Physiologic
  • Nerve Regeneration
  • Neural Stem Cells
  • Neurodegenerative Diseases
  • Neurogenesis
  • Neurons
  • Octamer Transcription Factor-3
  • Plasmids
  • Pluripotent Stem Cells
  • Promoter Regions, Genetic
  • RNA Interference
  • RNA Polymerase III
  • Reverse Transcriptase Polymerase Chain Reaction
  • Signal Transduction
  • Spinal Cord Diseases
  • Stem Cell Transplantation
  • Stem Cells
  • Tissue Engineering
  • Transcription Factors
  • Transfection
  • Transplantation, Heterologous
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Velkey, JM, and O'Shea, KS. "Expression of Neurogenin 1 in Mouse Embryonic Stem Cells Directs the Differentiation of Neuronal Precursors and Identifies Unique Patterns of Down-stream Gene Expression." Dev Dyn 242, no. 5 (May 2013): C1-.  Full Text  Link to Item
    • Velkey, JM, and O'Shea, KS. "Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression." Dev Dyn 242, no. 3 (March 2013): 230-253.  Full Text  Link to Item
    • Purcell, EK, Yang, A, Liu, L, Velkey, JM, Morales, MM, and Duncan, RK. "BDNF profoundly and specifically increases KCNQ4 expression in neurons derived from embryonic stem cells." Stem Cell Research 10, no. 1 (January 2013): 29-35.  Full Text
    • Purcell, EK, Naim, Y, Yang, A, Leach, MK, Velkey, JM, Duncan, RK, and Corey, JM. "Combining topographical and genetic cues to promote neuronal fate specification in stem cells." Biomacromolecules 13, no. 11 (November 2012): 3427-3438. (Review)  Full Text
    • Hill, GW, Purcell, EK, Liu, L, Velkey, JM, Altschuler, RA, and Duncan, RK. "Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1." Stem Cells Dev 21, no. 15 (October 10, 2012): 2827-2837.  Full Text  Link to Item
    • Lunn, JS, Pacut, C, Stern, E, Sakowski, SA, Velkey, JM, O'Shea, S, and Feldman, EL. "Intraspinal transplantation of neurogenin-expressing stem cells generates spinal cord neural progenitors." Neurobiol Dis 46, no. 1 (April 2012): 59-68.  Full Text  Link to Item
    • Reyes, JH, O'Shea, KS, Wys, NL, Velkey, JM, Prieskorn, DM, Wesolowski, K, Miller, JM, and Altschuler, RA. "Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies." The Journal of Neuroscience : the Official Journal of the Society for Neuroscience 28, no. 48 (November 2008): 12622-12631.  Full Text
    • Rodriguez, RT, Velkey, JM, Lutzko, C, Seerke, R, Kohn, DB, O'Shea, KS, and Firpo, MT. "Manipulation of OCT4 levels in human embryonic stem cells results in induction of differential cell types." Experimental Biology and Medicine (Maywood, N.J.) 232, no. 10 (November 2007): 1368-1380.  Full Text
    • Velkey, JM, Slawny, NA, Gratsch, TE, and O'Shea, KS. "Gene silencing using RNA interference in embryonic stem cells." Methods Mol Biol 329 (2006): 233-261.  Full Text  Link to Item
    • Velkey, JM, and O'Shea, KS. "Oct4 RNA interference induces trophectoderm differentiation in mouse embryonic stem cells." Genesis (New York, N.Y. : 2000) 37, no. 1 (September 2003): 18-24.  Full Text
    • Bernanke, DH, and Velkey, JM. "Development of the coronary blood supply: changing concepts and current ideas." Anat Rec 269, no. 4 (August 15, 2002): 198-208. (Review)  Full Text  Link to Item
    • Matthew Velkey, J, and Bernanke, DH. "Apoptosis during coronary artery orifice development in the chick embryo." Anatomical Record 262, no. 3 (March 1, 2001): 310-317.  Full Text
    • Velkey, JM, and Bernanke, DH. "Apoptosis during coronary artery orifice development in the chick embryo." The Anatomical Record 262, no. 3 (March 2001): 310-317.  Full Text
    • Velkey, JM, Naftel, JP, Ard, MD, Ma, TP, and Hoskins, GA. "Development of a digital electron micrograph atlas for medical histology education." FASEB JOURNAL 14, no. 4 (March 15, 2000): A308-A308.  Link to Item
    • Velkey, JM, and Bernanke, DK. "Developing coronary arteries in the chick acquire patent connections to the aorta by a mechanism involving apoptosis." FASEB JOURNAL 14, no. 4 (March 15, 2000): A21-A21.  Link to Item

  • Conference Papers

    • Taylor, AB, Velkey, JM, Gwyer, J, and White, LE. "Body and Brain: Anatomy of team-based learning in a preclinical science course." March 2015.  Link to Item
    • Velkey, JM, and O'Shea, KS. "Neuronal differentiation and subtype specification following inducible expression of neurogenin-1 in mouse embryonic stem cells." March 4, 2005.  Link to Item
    • Velkey, JM, and O'Shea, KS. "Knockdown of Oct3/4 expression in mouse embryonic stem cells by RNA interference." March 17, 2003.  Link to Item
• Teaching & Mentoring
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  Recent Courses

  • HLTHSCI 503: Organ Systems 2019

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