Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Ph.D., University of Pittsburgh 2001
• 

  Previous Appointments & Affiliations

  • Associate Professor of Surgery, Surgery, Urology, Surgery 2013 - 2020
  • Adjunct Assistant Professor in the Department of Surgery, Surgery, Urology, Surgery 2002 - 2013
• Research
• 

  Selected Grants

  • Duke KURe Program awarded by National Institutes of Health 2013 - 2023
  • Diabetes and Diabetic Uropathy awarded by National Institutes of Health 2017 - 2018
  • Intrathecal therapy for autonomic dysreflexia awarded by National Institutes of Health 2012 - 2015
  • Diabetic Urethral Pathophysiology and Afferent Therapy awarded by National Institutes of Health 2003 - 2009
• 

  External Relationships

  • Fernel Therapeutics
  • Lipella Pharma
  • Paxos Medical LTD
• Publications & Artistic Works
• 

  Selected Publications

  • Books

    • Peterson, A. C., and M. O. Fraser. Practical Urodynamics for the Clinician, 2016. https://doi.org/10.1007/978-3-319-20834-3.
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    • Peterson, A. C., and M. O. Fraser. Preface, 2016. https://doi.org/10.1007/978-3-319-20834-3.
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  • Academic Articles

    • Glaser, Alexander P., Sarah Mansfield, Abigail R. Smith, Brian T. Helfand, H Henry Lai, Aruna Sarma, Claire C. Yang, et al. “Impact of Sleep Disturbance, Physical Function, Depression and Anxiety on Male Lower Urinary Tract Symptoms: Results from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN).” J Urol 208, no. 1 (July 2022): 155–63. https://doi.org/10.1097/JU.0000000000002493.
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    • Bickhaus, Jennifer A., Matthew O. Fraser, Alison C. Weidner, Friederike L. Jayes, Cindy L. Amundsen, Ken Gall, Andrew T. Miller, Frank C. Marini, Stanley J. Robboy, and Nazema Y. Siddiqui. “Polycarbonate Urethane Mesh: A New Material for Pelvic Reconstruction.” Female Pelvic Med Reconstr Surg 27, no. 2 (February 1, 2021): e469–75. https://doi.org/10.1097/SPV.0000000000000964.
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    • Bickhaus, Jennifer A., Matthew O. Fraser, Alison C. Weidner, Friederike L. Jayes, Cindy L. Amundsen, Ken Gall, Frank C. Marini, Stanley J. Robboy, and Nazema Y. Siddiqui. “Evaluation of Host Immune Cellular and Extracellular Matrix Responses to Prolapse Mesh With and Without Tension in a Rat Model.” Female Pelvic Medicine & Reconstructive Surgery 27, no. 2 (February 2021): e385–91. https://doi.org/10.1097/spv.0000000000000943.
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    • Fraser, Matthew O., Phillip P. Smith, Maryrose P. Sullivan, Dale E. Bjorling, Lysanne Campeau, Karl-Erik Andersson, and Mitsuharu Yoshiyama. “Best practices for cystometric evaluation of lower urinary tract function in muriform rodents.” Neurourol Urodyn 39, no. 6 (August 2020): 1868–84. https://doi.org/10.1002/nau.24415.
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    • Amundsen, Cindy L., Margaret E. Helmuth, Abigail R. Smith, John O. L. DeLancey, Catherine S. Bradley, Kathryn E. Flynn, Kimberly S. Kenton, et al. “Longitudinal changes in symptom-based female and male LUTS clusters.” Neurourol Urodyn 39, no. 1 (January 2020): 393–402. https://doi.org/10.1002/nau.24219.
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    • Cameron, Anne P., Jonathan B. Wiseman, Abigail R. Smith, Robert M. Merion, Brenda W. Gillespie, Catherine S. Bradley, Cindy L. Amundsen, et al. “Are three-day voiding diaries feasible and reliable? Results from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) cohort.” Neurourol Urodyn 38, no. 8 (November 2019): 2185–93. https://doi.org/10.1002/nau.24113.
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    • Potts, Bradley A., Danielle J. Degoski, Jillene M. Brooks, Andrew C. Peterson, Dwight E. Nelson, Thaddeus S. Brink, and Matthew O. Fraser. “Timing of sacral neurostimulation is important for increasing bladder capacity in the anesthetized rat.” Am J Physiol Renal Physiol 317, no. 5 (November 1, 2019): F1183–88. https://doi.org/10.1152/ajprenal.00167.2019.
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    • Liu, Alice B., Qian Liu, Claire C. Yang, James W. Griffith, Abigail R. Smith, Margaret E. Helmuth, H Henry Lai, et al. “Patient Characteristics Associated with More Bother from Lower Urinary Tract Symptoms.” J Urol 202, no. 3 (September 2019): 585–91. https://doi.org/10.1097/JU.0000000000000324.
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    • Peterson, Andrew C., Abigail R. Smith, Matthew O. Fraser, Claire C. Yang, John O. L. DeLancey, Brenda W. Gillespie, John L. Gore, et al. “The Distribution of Post-Void Residual Volumes in People Seeking Care in the Symptoms of Lower Urinary Tract Dysfunction Network Observational Cohort Study With Comparison to Asymptomatic Populations.” Urology 130 (August 2019): 22–28. https://doi.org/10.1016/j.urology.2019.01.069.
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    • Powers, Shelby A., Terence E. Ryan, Elena S. Pak, Matthew O. Fraser, Joseph M. McClung, and Johanna L. Hannan. “Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions.” Neurourol Urodyn 38, no. 6 (August 2019): 1524–32. https://doi.org/10.1002/nau.24015.
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    • Andreev, Victor P., Gang Liu, Claire C. Yang, Abigail R. Smith, Margaret E. Helmuth, Jonathan B. Wiseman, Robert M. Merion, et al. “Symptom Based Clustering of Women in the LURN Observational Cohort Study.” J Urol 200, no. 6 (December 2018): 1323–31. https://doi.org/10.1016/j.juro.2018.06.068.
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    • Cameron, Anne P., Abigail R. Smith, H Henry Lai, Catherine S. Bradley, Alice B. Liu, Robert M. Merion, Brenda W. Gillespie, et al. “Bowel function, sexual function, and symptoms of pelvic organ prolapse in women with and without urinary incontinence.” Neurourol Urodyn 37, no. 8 (November 2018): 2586–96. https://doi.org/10.1002/nau.23587.
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    • Abelson, Benjamin, Daniel Sun, Lauren Que, Rebecca A. Nebel, Dylan Baker, Patrick Popiel, Cindy L. Amundsen, et al. “Sex differences in lower urinary tract biology and physiology.” Biol Sex Differ 9, no. 1 (October 22, 2018): 45. https://doi.org/10.1186/s13293-018-0204-8.
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    • Qiao, Li-Ya, Chunmei Xia, Shanwei Shen, Seong Ho Lee, Paul H. Ratz, Matthew O. Fraser, Amy Miner, John E. Speich, Jeffrey J. Lysiak, and William D. Steers. “Urinary bladder organ hypertrophy is partially regulated by Akt1-mediated protein synthesis pathway.” Life Sci 201 (May 15, 2018): 63–71. https://doi.org/10.1016/j.lfs.2018.03.041.
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    • Vaughan, Camille P., Alayne D. Markland, Phillip P. Smith, Kathryn L. Burgio, George A. Kuchel, and George A. American Geriatrics Society/National Institute on Aging Urinary Incontinence Conference Planning Committee and Faculty. “Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Urinary Incontinence in Older Adults: A Translational Research Agenda for a Complex Geriatric Syndrome.” J Am Geriatr Soc 66, no. 4 (April 2018): 773–82. https://doi.org/10.1111/jgs.15157.
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    • Siddiqui, Nazema Y., W Thomas Gregory, Victoria L. Handa, John O. L. DeLancey, Holly E. Richter, Pamela Moalli, Matthew D. Barber, et al. “American Urogynecologic Society Prolapse Consensus Conference Summary Report.” Female Pelvic Med Reconstr Surg 24, no. 4 (2018): 260–63. https://doi.org/10.1097/SPV.0000000000000533.
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    • Doggweiler, Regula, Kristene E. Whitmore, Jane M. Meijlink, Marcus J. Drake, Helena Frawley, Jørgen Nordling, Philip Hanno, et al. “A standard for terminology in chronic pelvic pain syndromes: A report from the chronic pelvic pain working group of the international continence society.” Neurourol Urodyn 36, no. 4 (April 2017): 984–1008. https://doi.org/10.1002/nau.23072.
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    • Kim, Sang Woon, Hee Seo Son, Irela Soto Troya, Ji Yu Kim, Myoung Joo Kim, Matthew O. Fraser, and Jang Hwan Kim. “Autonomic response during bladder hydrodistention reflects the severity of symptoms in patients with bladder pain syndrome/interstitial cystitis.” Neurourology and Urodynamics 36, no. 3 (March 2017): 677–82. https://doi.org/10.1002/nau.22994.
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    • Losada, Liliana, Cindy L. Amundsen, James Ashton-Miller, Toby Chai, Clare Close, Margot Damaser, Michael DiSanto, et al. “Expert Panel Recommendations on Lower Urinary Tract Health of Women Across Their Life Span.” J Womens Health (Larchmt) 25, no. 11 (November 2016): 1086–96. https://doi.org/10.1089/jwh.2016.5895.
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    • Yang, Claire C., Kevin P. Weinfurt, Robert M. Merion, Ziya Kirkali, and Ziya LURN Study Group. “Symptoms of Lower Urinary Tract Dysfunction Research Network.” J Urol 196, no. 1 (July 2016): 146–52. https://doi.org/10.1016/j.juro.2016.01.007.
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    • Yang, Claire C., Kevin P. Weinfurt, Robert M. Merion, Ziya Kirkali, and Ziya LURN Study Group. “Symptoms of Lower Urinary Tract Dysfunction Research Network.” J Urol 196, no. 1 (July 2016): 146–52. https://doi.org/10.1016/j.juro.2016.01.007.
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    • Visco, Anthony G., Matthew O. Fraser, Donald Newgreen, Matthias Oelke, and Linda Cardozo. “What is the role of combination drug therapy in the treatment of overactive bladder? ICI-RS 2014.” Neurourol Urodyn 35, no. 2 (February 2016): 288–92. https://doi.org/10.1002/nau.22795.
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    • Dieter, Alexis A., Jennifer M. Wu, Nazema Y. Siddiqui, Danielle J. Degoski, Jillene M. Brooks, Paul C. Dolber, and Matthew O. Fraser. “Characterizing the Bladder's Response to Onabotulinum Toxin Type A Using a Rat Model.” Female Pelvic Med Reconstr Surg 22, no. 6 (2016): 467–71. https://doi.org/10.1097/SPV.0000000000000316.
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    • Dieter, Alexis A., Danielle J. Degoski, Paul C. Dolber, and Matthew O. Fraser. “The effects of bilateral bipolar sacral neurostimulation on urinary bladder activity during filling before and after irritation in a rat model.” Neurourol Urodyn 34, no. 4 (April 2015): 387–91. https://doi.org/10.1002/nau.22556.
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    • Dolber, Paul C., Huixia Jin, Rashid Nassar, Thomas M. Coffman, Susan B. Gurley, and Matthew O. Fraser. “The effects of Ins2(Akita) diabetes and chronic angiotensin II infusion on cystometric properties in mice.” Neurourol Urodyn 34, no. 1 (January 2015): 72–78. https://doi.org/10.1002/nau.22511.
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    • Siddiqui, Nazema Y., Laura G. DuBois, Lisa St John-Williams, Thompson J. Will, Carole Grenier, Emily Burke, Matthew O. Fraser, Cindy L. Amundsen, and Susan K. Murphy. “Optimizing Urine Processing Protocols for Protein and Metabolite Detection.” J Proteomics Bioinform 2015, no. Suppl 14 (2015).
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    • Ustinova, E. E., M. O. Fraser, and M. A. Pezzone. “Cross-talk and sensitization of bladder afferent nerves.” Journal of Urology 186, no. 2 (August 1, 2011): 615. https://doi.org/10.1016/j.juro.2011.04.054.
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    • Fraser, M. O. “New Insights into the Pathophysiology of Detrusor-Sphincter Dyssynergia.” Current Bladder Dysfunction Reports 6, no. 2 (June 1, 2011): 93–99. https://doi.org/10.1007/s11884-011-0083-x.
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    • Wu, Christine H., CA Tony Buffington, Matthew O. Fraser, and Jodi L. Westropp. “Urodynamic evaluation of female cats with idiopathic cystitis.” Am J Vet Res 72, no. 4 (April 2011): 578–82. https://doi.org/10.2460/ajvr.72.4.578.
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    • Yang, Zhongguang, Paul C. Dolber, and Matthew O. Fraser. “Differential vulnerabilities of urethral afferents in diabetes and discovery of a novel urethra-to-urethra reflex.” Am J Physiol Renal Physiol 298, no. 1 (January 2010): F118–24. https://doi.org/10.1152/ajprenal.00281.2009.
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    • Christ, George J., Wade Bushman, and Matthew O. Fraser. “Impact of diabetes and obesity on the prostate and urethra: implications to improved bladder dysfunction understanding and treatment.” J Urol 182, no. 6 Suppl (December 2009): S38–44. https://doi.org/10.1016/j.juro.2009.07.085.
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    • Hougaard, C., M. O. Fraser, C. Chien, A. Bookout, M. Katofiasc, B. S. Jensen, F. Rode, et al. “A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo.” J Pharmacol Exp Ther 328, no. 1 (January 2009): 28–39. https://doi.org/10.1124/jpet.108.143123.
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    • Zhang, Xiaoyang, Kristy L. Douglas, Huixia Jin, Bassem M. Eldaif, Rashid Nassar, Matthew O. Fraser, and Paul C. Dolber. “Sprouting of substance P-expressing primary afferent central terminals and spinal micturition reflex NK1 receptor dependence after spinal cord injury.” Am J Physiol Regul Integr Comp Physiol 295, no. 6 (December 2008): R2084–96. https://doi.org/10.1152/ajpregu.90653.2008.
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    • Yang, Zhongguang, Rashid Nassar, Paul C. Dolber, and Matthew O. Fraser. “Voltage-dependent potassium currents of urethral afferent neurons in diabetes mellitus.” Brain Res 1217 (June 27, 2008): 132–38. https://doi.org/10.1016/j.brainres.2008.03.055.
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    • Yang, Zhongguang, Paul C. Dolber, and Matthew O. Fraser. “Diabetic urethropathy compounds the effects of diabetic cystopathy.” J Urol 178, no. 5 (November 2007): 2213–19. https://doi.org/10.1016/j.juro.2007.06.042.
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    • Christianson, Julie A., Ruomei Liang, Elena E. Ustinova, Brian M. Davis, Matthew O. Fraser, and Michael A. Pezzone. “Convergence of bladder and colon sensory innervation occurs at the primary afferent level.” Pain 128, no. 3 (April 2007): 235–43. https://doi.org/10.1016/j.pain.2006.09.023.
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    • Dolber, Paul C., Baojun Gu, Xiaoyang Zhang, Matthew O. Fraser, Karl B. Thor, and Jerome P. Reiter. “Activation of the external urethral sphincter central pattern generator by a 5-HT(1A) receptor agonist in rats with chronic spinal cord injury.” Am J Physiol Regul Integr Comp Physiol 292, no. 4 (April 2007): R1699–1706. https://doi.org/10.1152/ajpregu.00142.2006.
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    • Liang, Ruomei, Elena E. Ustinova, Radhika Patnam, Matthew O. Fraser, Dmitriy W. Gutkin, and Michael A. Pezzone. “Enhanced expression of mast cell growth factor and mast cell activation in the bladder following the resolution of trinitrobenzenesulfonic acid (TNBS) colitis in female rats.” Neurourol Urodyn 26, no. 6 (2007): 887–93. https://doi.org/10.1002/nau.20410.
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    • Ustinova, Elena E., Matthew O. Fraser, and Michael A. Pezzone. “Colonic irritation in the rat sensitizes urinary bladder afferents to mechanical and chemical stimuli: an afferent origin of pelvic organ cross-sensitization.” Am J Physiol Renal Physiol 290, no. 6 (June 2006): F1478–87. https://doi.org/10.1152/ajprenal.00395.2005.
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    • Pezzone, Michael A., Ruomei Liang, and Matthew O. Fraser. “A model of neural cross-talk and irritation in the pelvis: implications for the overlap of chronic pelvic pain disorders.” Gastroenterology 128, no. 7 (June 2005): 1953–64. https://doi.org/10.1053/j.gastro.2005.03.008.
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    • Burgard, Edward C., Matthew O. Fraser, Venkateswarlu Karicheti, Daniel J. Ricca, and Karl B. Thor. “New pharmacological treatments for urinary incontinence and overactive bladder.” Curr Opin Investig Drugs 6, no. 1 (January 2005): 81–89.
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    • Fraser, Matthew O., Muhammad Arslan, and Tony M. Plant. “Androgen and estrogen treatment, alone or in combination, differentially influences bone maturation and hypothalamic mechanisms that time puberty in the male rhesus monkey (Macaca mulatta).” Pediatr Res 57, no. 1 (January 2005): 141–48. https://doi.org/10.1203/01.PDR.0000148063.68338.A0.
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    • Torimoto, Kazumasa, Matthew O. Fraser, Yoshihiko Hirao, William C. De Groat, Michael B. Chancellor, and Naoki Yoshimura. “Urethral dysfunction in diabetic rats.” J Urol 171, no. 5 (May 2004): 1959–64. https://doi.org/10.1097/01.ju.0000121283.92963.05.
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    • Yu, Yongbei, Mathew O. Fraser, and William C. de Groat. “Effects of ZD6169, a K ATP channel opener, on neurally-mediated plasma extravasation in the rat urinary bladder induced by chemical or electrical stimulation of nerves.” Brain Res 996, no. 1 (January 16, 2004): 41–46. https://doi.org/10.1016/j.brainres.2003.10.007.
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    • Gu, Baojun, Matthew O. Fraser, Karl B. Thor, and Paul C. Dolber. “Induction of bladder sphincter dyssynergia by kappa-2 opioid receptor agonists in the female rat.” J Urol 171, no. 1 (January 2004): 472–77. https://doi.org/10.1097/01.ju.0000092069.00376.5c.
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    • Tyagi, Pradeep, Michael B. Chancellor, Zhenhua Li, William C. De Groat, Naoki Yoshimura, Matthew O. Fraser, and Leaf Huang. “Urodynamic and immunohistochemical evaluation of intravesical capsaicin delivery using thermosensitive hydrogel and liposomes.” J Urol 171, no. 1 (January 2004): 483–89. https://doi.org/10.1097/01.ju.0000102360.11785.d7.
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    • Chermansky, Christopher J., Tracy W. Cannon, Kazumasa Torimoto, Matthew O. Fraser, Naoki Yoshimura, William C. de Groat, and Michael B. Chancellor. “A model of intrinsic sphincteric deficiency in the rat: electrocauterization.” Neurourol Urodyn 23, no. 2 (2004): 166–71. https://doi.org/10.1002/nau.10173.
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    • Burgard, Edward C., Mathew O. Fraser, and Karl B. Thor. “Serotonergic modulation of bladder afferent pathways.” Urology 62, no. 4 Suppl 1 (October 2003): 10–15. https://doi.org/10.1016/s0090-4295(03)00590-9.
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    • Fraser, M. O., and M. B. Chancellor. “Neural control of the urethra and development of pharmacotherapy for stress urinary incontinence.” Bju Int 91, no. 8 (May 2003): 743–48. https://doi.org/10.1046/j.1464-410x.2003.04161.x.
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    • Chuang, Yao-Chi, Michael B. Chancellor, Satoshi Seki, Naoki Yoshimura, Pradeep Tyagi, Leaf Huang, John P. Lavelle, William C. De Groat, and Matthew O. Fraser. “Intravesical protamine sulfate and potassium chloride as a model for bladder hyperactivity.” Urology 61, no. 3 (March 2003): 664–70. https://doi.org/10.1016/s0090-4295(02)02280-x.
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    • Fraser, Matthew O., Yao-Chi Chuang, Pradeep Tyagi, Teruhiko Yokoyama, Naoki Yoshimura, Leaf Huang, William C. De Groat, and Michael B. Chancellor. “Intravesical liposome administration--a novel treatment for hyperactive bladder in the rat.” Urology 61, no. 3 (March 2003): 656–63. https://doi.org/10.1016/s0090-4295(02)02281-1.
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    • Lee, J. Y., T. W. Cannon, R. Pruchnic, M. O. Fraser, J. Huard, and M. B. Chancellor. “The effects of periurethral muscle-derived stem cell injection on leak point pressure in a rat model of stress urinary incontinence.” Int Urogynecol J Pelvic Floor Dysfunct 14, no. 1 (February 2003): 31–37. https://doi.org/10.1007/s00192-002-1004-5.
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    • Seki, Satoshi, Katsumi Sasaki, Matthew O. Fraser, Yasuhiko Igawa, Osamu Nishizawa, Michael B. Chancellor, William C. de Groat, and Naoki Yoshimura. “Immunoneutralization of nerve growth factor in lumbosacral spinal cord reduces bladder hyperreflexia in spinal cord injured rats.” J Urol 168, no. 5 (November 2002): 2269–74. https://doi.org/10.1016/S0022-5347(05)64369-8.
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    • Sasaki, Katsumi, Michael B. Chancellor, Michael W. Phelan, Teruhiko Yokoyama, Matthew O. Fraser, Satoshi Seki, Kazuyuki Kubo, Hiromi Kumon, William C. Groat, and Naoki Yoshimura. “Diabetic cystopathy correlates with a long-term decrease in nerve growth factor levels in the bladder and lumbosacral dorsal root Ganglia.” J Urol 168, no. 3 (September 2002): 1259–64. https://doi.org/10.1016/S0022-5347(05)64636-8.
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    • Gloeckner, D Claire, Michael S. Sacks, Matthew O. Fraser, George T. Somogyi, William C. de Groat, and Michael B. Chancellor. “Passive biaxial mechanical properties of the rat bladder wall after spinal cord injury.” J Urol 167, no. 5 (May 2002): 2247–52.
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    • Fraser, Matthew O., John P. Lavelle, Michael S. Sacks, and Michael B. Chancellor. “The future of bladder control-intravesical drug delivery, a pinch of pepper, and gene therapy.” Rev Urol 4, no. 1 (2002): 1–11.
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    • Fraser, M. O., Y. C. Chuang, D. Y. Kim, C. M. Brady, J. M. Beckel, N. Yoshimura, W. C. de Groat, and M. B. Chancellor. “Intravesical ultrapotent vanilloid receptor agonists: acute effects on animal models of bladder irritation.” Urology 57, no. 6 Suppl 1 (June 2001): 111–12. https://doi.org/10.1016/s0090-4295(01)01043-3.
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    • Fraser, M. O., Y. C. Chuang, J. P. Lavelle, N. Yoshimura, W. C. de Groat, and M. B. Chancellor. “A reliable, nondestructive animal model for interstitial cystitis: intravesical low-dose protamine sulfate combined with physiological concentrations of potassium chloride.” Urology 57, no. 6 Suppl 1 (June 2001): 112. https://doi.org/10.1016/s0090-4295(01)01044-5.
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    • Yoshimura, N., M. E. Franks, K. Sasaki, W. F. Goins, J. Goss, T. Yokoyama, M. O. Fraser, et al. “Gene therapy of bladder pain with herpes simplex virus (HSV) vectors expressing preproenkephalin (PPE).” Urology 57, no. 6 Suppl 1 (June 2001): 116. https://doi.org/10.1016/s0090-4295(01)01060-3.
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    • Yoshimura, N., S. Seki, V. Erickson, K. Erickson, L. Kassotakis, S. Novakovic, M. O. Fraser, M. B. Chancellor, and W. C. de Groat. “Suppression of the tetrodotoxin-resistant sodium channel (PN3/SNS): a possible new treatment for bladder pain.” Urology 57, no. 6 Suppl 1 (June 2001): 116–17. https://doi.org/10.1016/s0090-4295(01)01061-5.
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    • Phelan, M. W., M. Franks, G. T. Somogyi, T. Yokoyama, M. O. Fraser, J. P. Lavelle, N. Yoshimura, and M. B. Chancellor. “Botulinum toxin urethral sphincter injection to restore bladder emptying in men and women with voiding dysfunction.” J Urol 165, no. 4 (April 2001): 1107–10.
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    • Chuang, Y. C., M. O. Fraser, Y. Yu, M. B. Chancellor, W. C. de Groat, and N. Yoshimura. “The role of bladder afferent pathways in bladder hyperactivity induced by the intravesical administration of nerve growth factor.” J Urol 165, no. 3 (March 2001): 975–79.
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    • Groat, W. C. de, M. O. Fraser, M. Yoshiyama, S. Smerin, C. Tai, M. B. Chancellor, N. Yoshimura, and J. R. Roppolo. “Neural control of the urethra.” Scand J Urol Nephrol Suppl, no. 207 (2001): 35–43. https://doi.org/10.1080/003655901750174872.
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    • Yokoyama, T., N. Yoshimura, R. Dhir, Z. Qu, M. O. Fraser, H. Kumon, W. C. de Groat, J. Huard, and M. B. Chancellor. “Persistence and survival of autologous muscle derived cells versus bovine collagen as potential treatment of stress urinary incontinence.” J Urol 165, no. 1 (January 2001): 271–76. https://doi.org/10.1097/00005392-200101000-00077.
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    • Hirano, A., P. P. Luke, S. M. Specht, M. O. Fraser, T. Takayama, L. Lu, R. Hoffman, A. W. Thomson, and M. L. Jordan. “Graft hyporeactivity induced by immature donor-derived dendritic cells.” Transpl Immunol 8, no. 3 (November 2000): 161–68. https://doi.org/10.1016/s0966-3274(00)00022-8.
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    • Yoshiyama, M., W. C. deGroat, and M. O. Fraser. “Influences of external urethral sphincter relaxation induced by alpha-bungarotoxin, a neuromuscular junction blocking agent, on voiding dysfunction in the rat with spinal cord injury.” Urology 55, no. 6 (June 2000): 956–60. https://doi.org/10.1016/s0090-4295(00)00474-x.
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    • Hirano, A., M. O. Fraser, M. L. Jordan, T. Takayama, L. Lu, and A. W. Thomson. “Graft hyporeactivity induced by donor-derived dendritic cell progenitors.” Transplant Proc 32, no. 2 (March 2000): 260–64. https://doi.org/10.1016/s0041-1345(99)00951-3.
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    • Ozawa, H., M. B. Chancellor, S. Y. Jung, T. Yokoyama, M. O. Fraser, Y. Yu, W. C. de Groat, and N. Yoshimura. “Effect of intravesical nitric oxide therapy on cyclophosphamide-induced cystitis.” J Urol 162, no. 6 (December 1999): 2211–16. https://doi.org/10.1016/S0022-5347(05)68161-X.
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    • Jung, S. Y., M. O. Fraser, H. Ozawa, O. Yokoyama, M. Yoshiyama, W. C. De Groat, and M. B. Chancellor. “Urethral afferent nerve activity affects the micturition reflex; implication for the relationship between stress incontinence and detrusor instability.” J Urol 162, no. 1 (July 1999): 204–12. https://doi.org/10.1097/00005392-199907000-00069.
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    • Fagerli, Julian, Matthew O. Fraser, William C. deGroat, Michael B. Chancellor, Hugh Declan Flood, Deidre Smith, and Mark L. Jordan. “Intravesical capsaicin for the treatment of interstitial cystitis: a pilot study.” Can J Urol 6, no. 2 (April 1999): 737–44.
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    • Ozawa, H., S. Y. Jung, M. O. Fraser, D. A. Rivas, and M. B. Chancellor. “Intravesical capsaicin therapy: a review.” J Spinal Cord Med 22, no. 2 (1999): 114–18. https://doi.org/10.1080/10790268.1999.11719556.
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    • Bennett, B. C., M. N. Kruse, J. R. Roppolo, H. D. Flood, M. Fraser, and W. C. de Groat. “Neural control of urethral outlet activity in vivo: role of nitric oxide.” J Urol 153, no. 6 (June 1995): 2004–9.
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    • Fraser, M. O., and T. M. Plant. “Further studies on the role of the gonads in determining the ontogeny of gonadotropin secretion in the guinea pig (Cavia porcelus).” Endocrinology 125, no. 2 (August 1989): 906–11. https://doi.org/10.1210/endo-125-2-906.
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    • Fraser, M. O., C. R. Pohl, and T. M. Plant. “The hypogonadotropic state of the prepubertal male rhesus monkey (Macaca mulatta) is not associated with a decrease in hypothalamic gonadotropin-releasing hormone content.” Biol Reprod 40, no. 5 (May 1989): 972–80. https://doi.org/10.1095/biolreprod40.5.972.
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    • Robinson, F. R., M. O. Fraser, J. R. Hollerman, and D. L. Tomko. “Yaw direction neurons in the cat inferior olive.” J Neurophysiol 60, no. 5 (November 1988): 1739–52. https://doi.org/10.1152/jn.1988.60.5.1739.
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  • Book Sections

    • Fraser, M. O. “The basic science behind practical/clinical urodynamic analysis.” In Practical Urodynamics for the Clinician, 1–8, 2016. https://doi.org/10.1007/978-3-319-20834-3_1.
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  • Other Articles

    • Yang, Z., R. Nassar, P. C. Dolber, and M. O. Fraser. “Corrigendum to "Voltage-dependent potassium currents of urethral afferent neurons in diabetes mellitus" [Brain Res. 1217 (2008) 132-138] (DOI:10.1016/j.brainres.2008.03.055).” Brain Research, December 3, 2008. https://doi.org/10.1016/j.brainres.2008.08.034.
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    • Jankowski, R. J., D. A. Vorp, R. L. Prantil, K. Torimoto, M. B. Chancellor, M. O. Fraser, and J. Huard. “Establishing a system for the study of urethral biomechanical function.” Annual International Conference of the Ieee Engineering in Medicine and Biology  Proceedings, December 1, 2002.
    • Prantil, R. L., R. J. Jankowski, K. Torimoto, W. C. De Groat, M. B. Chancellor, M. O. Fraser, and D. A. Vorp. “Effects of diabetes mellitus on the biomechanical properties of the female rat urethra.” Annual International Conference of the Ieee Engineering in Medicine and Biology  Proceedings, December 1, 2002.
    • Plant, T. M., M. O. Fraser, R. Medhamurthy, and V. L. Gay. “Somatogenic control of GnRH neuronal synchronization during development in primates: A speculation.” Control of the Onset of Puberty Iii: Proceedings of the 3rd International Conference of the Control of the Onset of Puberty. Ics861, December 1, 1989.
    • Fraser, M. O., C. R. Pohl, and T. M. Plant. “Erratum: The hypogonadotropic state of the prepubertal male rhesus monkey (Macaca mulatta) (Biology of Reproduction (1989) (Volume 40, Number 5 (972-980))).” Biology of Reproduction, January 1, 1989.

  • Conference Papers

    • Amundsen, Cindy L., Margaret E. Helmuth, Abigail R. Smith, John O. L. DeLancey, Catherine S. Bradley, Kathryn E. Flynn, Kimberly S. Kenton, et al. “LONGITUDINAL CHANGES IN SYMPTOM-BASED FEMALE AND MALE LUTS CLUSTER CHARACTERISTICS AND FACTORS ASSOCIATED WITH CHANGE.” In Journal of Urology, 201:E568–69. LIPPINCOTT WILLIAMS & WILKINS, 2019.
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    • Amundsen, Cindy L., Margaret E. Helmuth, Abigail R. Smith, John O. L. DeLancey, Catherine S. Bradley, Kathryn E. Flynn, Kimberly S. Kenton, et al. “Longitudinal changes in symptom-based female and male luts cluster characteristics and factors associated with change.” In Neurourology and Urodynamics, 38:S85–86. WILEY, 2019.
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    • Andreev, Victor P., Gang Liu, Claire C. Yang, Abigail R. Smith, Margaret E. Helmuth, Jonathan B. Wiseman, Robert M. Merion, et al. “SYMPTOM-BASED CLUSTERING OF FEMALE LUTS PARTICIPANTS IN THE SYMPTOMS OF LOWER URINARY TRACT DYSFUNCTION RESEARCH NETWORK (LURN) STUDY.” In Neurourology and Urodynamics, 37:S622–S622. WILEY, 2018.
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    • Chang, Doreen, Bryce A. Allio, Jillene M. Brooks, Danielle J. Degoski, A Adam Kahokehr, Andrew C. Peterson, and Matthew O. Fraser. “PROPHYLACTIC TREATMENT MARKEDLY IMPROVES BLADDER CAPACITY FOLLOWING PELVIC RADIATION.” In Neurourology and Urodynamics, 37:S540–S540. WILEY, 2018.
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    • Fraser, Matthew O., Abigail R. Smith, Claire C. Yang, John O. L. DeLancey, Brenda W. Gillespie, John L. Gore, Pooja Talaty, et al. “THE DISTRIBUTION OF POST-VOID RESIDUAL VOLUMES (PVR) IN PEOPLE SEEKING CARE: AN ANALYSIS OF 880 PARTICIPANTS OF THE SYMPTOMS OF LOWER URINARY TRACT DYSFUNCTION NETWORK (LURN) OBSERVATIONAL COHORT STUDY.” In Neurourology and Urodynamics, 37:S570–71. WILEY, 2018.
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    • Inouye, Brian M., Jillene M. Brooks, Danielle J. Degoski, Francis M. Hughes Jr., J Todd Purves, and Matthew O. Fraser. “MP85-02 ABERRANT BLADDER REFLEXES CAN DRIVE HIND LIMB LOCOMOTOR ACTIVITY FOLLOWING COMPLETE SUPRASACRAL SPINAL CORD INJURY.” In Journal of Urology, Vol. 197. Ovid Technologies (Wolters Kluwer Health), 2017. https://doi.org/10.1016/j.juro.2017.02.2664.
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    • Brooks, Jillene M., Danielle J. Degoski, and Matthew O. Fraser. “THE EFFECTS OF MYRBETRIQ ON DETRUSOR OVERACTIVITY ASSOCIATED WITH SUPRASACRAL SPINAL CORD INJURY (SCI) IN RATS.” In Neurourology and Urodynamics, 36:S20–21. WILEY-BLACKWELL, 2017.
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    • Inouye, Brian M., Jillene M. Brooks, Danielle J. Degoski, Francis M. Hughes, J Todd Purves, and Matthew O. Fraser. “ABERRANT BLADDER REFLEXES CAN DRIVE HIND LIMB LOCOMOTOR ACTIVITY FOLLOWING COMPLETE SUPRASACRAL SPINAL CORD INJURY.” In Neurourology and Urodynamics, 36:S20–S20. WILEY-BLACKWELL, 2017.
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    • Potts, B. A., D. J. Degoski, J. M. Brooks, A. C. Peterson, D. E. Nelson, T. Brink, and M. O. Fraser. “DIFFERENTIAL RESPONSIVENESS TO SACRAL NEUROSTIMULATION ACROSS THE BLADDER FILLING CYCLE IN RODENTS: LATER-PHASE IS MORE EFFECTIVE FOR INCREASING BLADDER CAPACITY THAN EARLIER-PHASE STIMULATION.” In Neurourology and Urodynamics, 35:S132–33. WILEY-BLACKWELL, 2016.
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    • Potts, Bradley A., Danielle J. Degoski, Jillene M. Brooks, Andrew C. Peterson, Dwight E. Nelson, Thaddeus S. Brink, and Matthew O. Fraser. “LATE INTERMITTENT SACRAL NEUROSTIMULATION SIGNIFICANTLY INCREASES BLADDER CAPACITY.” In Neurourology and Urodynamics, 35:S13–S13. WILEY-BLACKWELL, 2016.
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    • Brooks, J. M., D. J. Degoski, P. C. Dolber, and M. O. Fraser. “CELL THERAPY FOR NEUROGENIC DETRUSOR OVERACTIVITY: PROOF OF CONCEPT USING INTRAMURAL IMPLANTATION OF ADRENAL MEDULLARY CHROMAFFIN CELLS FOLLOWING CHRONIC SUPRASACRAL SPINAL CORD INJURY.” In Neurourology and Urodynamics, 34:S286–87. WILEY-BLACKWELL, 2015.
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    • Chermansky, C., K. Kadekawa, H. Okada, M. O. Fraser, P. Tyagi, and N. Yoshimura. “REDUCED AFFERENT SENSITIVITY IN THE RAT BILATERAL PELVIC NERVE CRUSH MODEL OF DETRUSOR UNDERACTIVITY.” In Neurourology and Urodynamics, 34:S193–94. WILEY-BLACKWELL, 2015.
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    • Lloyd, Jessica, Danielle J. Degoski, Jillene M. Brooks, Paul C. Dolber, and Matthew O. Fraser. “DIFFERENTIAL EFFECTS OF STEPWISE PHARMACOLOGICAL AUTONOMIC DENERVATION OR DIRECT SMOOTH MUSCLE RELAXATION ON URODYNAMIC INDICES IN CHRONIC SPINAL CORD INJURED RATS.” In Neurourology and Urodynamics, 34:S13–14. WILEY-BLACKWELL, 2015.
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    • Siddiqui, N. Y., A. A. Dieter, C. L. Amundsen, J. M. Brooks, D. J. Degoski, and M. O. Fraser. “UNDERACTIVE BLADDER IN OBESE-PRONE RATS FED A HIGH FAT DIET.” In Neurourology and Urodynamics, 33:952–53. WILEY-BLACKWELL, 2014.
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    • Dieter, A. A., J. M. Wu, N. Y. Siddiqui, D. J. Degoski, J. M. Brooks, P. C. Dolber, and M. O. Fraser. “ADEQUATE COMPENSATION? THE RESPONSE OF BLADDER SMOOTH MUSCLE TO BOTULINUM TOXIN TYPE A IN A RAT MODEL.” In International Urogynecology Journal, 25:S224–25. SPRINGER LONDON LTD, 2014.
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    • Fraser, M. O., J. C. Lloyd, N. Le, J. S. Wiener, and P. C. Dolber. “SUPERIOR EFFICACY OF COMBINATION PHARMACOTHERAPY FOR TREATMENT OF NEUROGENIC DETRUSOR OVERACTIVITY.” In International Urogynecology Journal, 25:S95–96. SPRINGER LONDON LTD, 2014.
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    • Lloyd, Jessica C., Le Ngoc-Bich, John S. Wiener, Paul C. Dolber, and Matthew O. Fraser. “COMBINATION PHARMACOTHERAPY FOR TREATMENT OF NEUROGENIC BLADDER.” In Neurourology and Urodynamics, 33:197–98. WILEY-BLACKWELL, 2014.
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    • Fraser, Matthew O., and Paul C. Dolber. “270 DRAMATIC ENHANCEMENT OF ANTIMUSCARINIC RESISTANT, HIGH AMPLITUDE NONVOIDING CONTRACTIONS BY INHIBITION OF THE SYMPATHETIC NERVOUS SYSTEM.” In Journal of Urology, Vol. 187. Ovid Technologies (Wolters Kluwer Health), 2012. https://doi.org/10.1016/j.juro.2012.02.327.
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    • Fraser, Matthew O., and Paul C. Dolber. “1647 STRIKING REDUCTION IN NEUROGENIC BLADDER DYSFUNCTION FOLLOWING REACTIVE OXYGEN SPECIES SCAVENGING IN THE LUMBOSACRAL SPINAL CORDS OF CHRONIC SPINAL CORD INJURED RATS.” In Journal of Urology, Vol. 187. Ovid Technologies (Wolters Kluwer Health), 2012. https://doi.org/10.1016/j.juro.2012.02.1479.
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    • Fraser, Matthew O., and Paul C. Dolber. “REACTIVE OXYGEN SPECIES IN THE SACRAL SPINAL CORD CONTRIBUTE TO NEUROGENIC BLADDER DYSFUNCTION IN SUPRASACRAL CHRONIC SPINAL CORD INJURY.” In Neurourology and Urodynamics, 31:241–42, 2012.
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    • Fraser, M. O., and P. C. Dolber. “VIDEO URODYNAMICS IN RATS REVEALS ACTIVE BLADDER DOME FILLING BY DIRECTIONAL CONTRACTION OF THE BASE.” In International Urogynecology Journal, 21:S94–95. SPRINGER LONDON LTD, 2010.
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    • Yang, Z., P. C. Dolber, and M. O. Fraser. “SIMULTANEOUS MULTI-POSITION URETHRAL BIOMECHANICS: THE EFFECTS OF DIABETES ON URETHRAL BIOMECHANICAL PROPERTIES IN THE RAT.” In International Urogynecology Journal, 21:S95–96. SPRINGER LONDON LTD, 2010.
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    • Chang, Liansheng, Zhongguang Yang, Paul C. Dolber, and Matthew O. Fraser. “OPPOSITE EFFECTS OF TYPE 1 DIABETES MELLITUS ON BLADDER AND URETHRAL SMOOTH MUSCLE STRIPS.” In Neurourology and Urodynamics, 29:256–256. WILEY-LISS, 2010.
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    • Fraser, M. O., and P. C. Dolber. “VIDEO URODYNAMICS IN RATS REVEALS ACTIVE BLADDER DOME FILLING BY DIRECTIONAL CONTRACTION OF THE BASE.” In Neurourology and Urodynamics, 29:898–99. WILEY-BLACKWELL, 2010.
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    • Fraser, Matthew O., and Paul C. Dolber. “URINE STORAGE IN THE RAT IS AN ACTIVE RATHER THAN PASSIVE PROCESS.” In Neurourology and Urodynamics, 29:259–259. WILEY-LISS, 2010.
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    • Yang, Z., P. C. Dolber, and M. O. Fraser. “SIMULTANEOUS MULTI-POSITION URETHRAL BIOMECHANICS: THE EFFECTS OF DIABETES ON URETHRAL BIOMECHANICAL PROPERTIES IN THE RAT.” In Neurourology and Urodynamics, 29:899–900. WILEY-BLACKWELL, 2010.
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    • Zhang, Xiaoyang, Ktisty L. Douglas, Huixia Jin, Matthew O. Fraser, and Paul C. Dolber. “Stimulation of the tachykinin NK1 receptor is required for the spinal micturition reflex in spinal cord injured (SCI) but not spinally intact rats.” In Journal of Urology, 179:350–350, 2008.
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    • Yang, Zhongguang, Paul C. Dolber, and Matthew O. Fraser. “255: Rescue of Urethral Relaxation By B3-Adrenoceptors in Diabetic Female Rats Following Loss of Nitrergic Mechanisms.” In Journal of Urology, 177:85–85. Ovid Technologies (Wolters Kluwer Health), 2007. https://doi.org/10.1016/s0022-5347(18)30520-2.
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    • Yang, Zhongguang, Paul C. Dolber, and Matthew O. Fraser. “Differential vulnerabilities of urethral afferents in diabetes and finding of a novel urethra-to-urethra reflex.” In Neurourology and Urodynamics, 26:1084–1084. WILEY-LISS, 2007.
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    • Ahmed, Rizwan, Elena E. Ustinova, Matthew O. Fraser, Dmitriy W. Gutkin, and Michael A. Pezzone. “Delayed Increase in Urinary Bladder Permeability Parallels Mast Cell Migration in TNBS Colitis.” In American Journal of Gastroenterology, 101:S485–86. Ovid Technologies (Wolters Kluwer Health), 2006. https://doi.org/10.14309/00000434-200609001-01255.
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    • Yang, Zhongguang, Paul C. Dolber, and Matthew O. Fraser. “1209: Diabetic Urethropathy Compounds the Effects of Diabetic Cystopathy: An Intensive in Vivo Study in the Rat.” In Journal of Urology, 173:328–328. Ovid Technologies (Wolters Kluwer Health), 2005. https://doi.org/10.1016/s0022-5347(18)35354-0.
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    • Gu, Baojun, Matthew O. Fraser, Karl B. Thor, and Paul C. Dolher. “536: Dramatic Reversal of Detrusor-Sphincter Dyssynergia in the Rat By a 5-HT1A Serotonin Receptor Agonist.” In Journal of Urology, 171:143–143. Ovid Technologies (Wolters Kluwer Health), 2004. https://doi.org/10.1016/s0022-5347(18)37798-x.
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    • Claire Gloeckner, D., M. S. Sacks, M. O. Fraser, M. B. Chancellor, G. T. Somogyi, and W. C. De Groat. “Active biaxial mechanical response of the urinary bladder wall.” In American Society of Mechanical Engineers, Bioengineering Division (Publication) Bed, 50:773–74, 2001.

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