Skip to main content

Matthew James Hilton

Associate Professor in Orthopaedic Surgery
Orthopaedic Surgery
450 Research Drive, LSRC B321C, DUMC 91009, Durham, NC 27710
91009, Durham, NC 27710

Overview


A long-term interest of the Hilton lab is to uncover the molecular circuitry regulating lineage commitment, proliferation, and differentiation of skeletal stem cells, chondrocytes, and osteoblasts. My laboratory uses genetic mouse models and primary cell culture techniques coupled with biochemistry to answer questions regarding skeletal stem cell self-renewal/differentiation, chondrogenesis, and osteoblastogenesis. Recently my lab has generated novel data from a variety of Notch gain and loss-of-function mutant mice demonstrating the importance of Notch signaling in each of these processes. We are currently investigating the exact Notch signaling mechanisms at play during skeletal development, disease, and repair. Additional studies are also focused on identifying and understanding the molecular mechanisms underlying various congenital skeletal pathologies, including Multiple Herediatry Exostoses (MHE) and Preaxial Polydactyly (PPD).

Current Appointments & Affiliations


Associate Professor in Orthopaedic Surgery · 2018 - Present Orthopaedic Surgery, Clinical Science Departments
Associate Professor in Cell Biology · 2015 - Present Cell Biology, Basic Science Departments
Affiliate of the Duke Regeneration Center · 2021 - Present Regeneration Next Initiative, Basic Science Departments

Education, Training & Certifications


University of Houston · 2004 Ph.D.