Matthew James Hilton | Scholars@Duke

Matthew James Hilton
Associate Professor in Orthopaedic Surgery

A long-term interest of the Hilton lab is to uncover the molecular circuitry regulating lineage commitment, proliferation, and differentiation of skeletal stem cells, chondrocytes, and osteoblasts. My laboratory uses genetic mouse models and primary cell culture techniques coupled with biochemistry to answer questions regarding skeletal stem cell self-renewal/differentiation, chondrogenesis, and osteoblastogenesis. Recently my lab has generated novel data from a variety of Notch gain and loss-of-function mutant mice demonstrating the importance of Notch signaling in each of these processes. We are currently investigating the exact Notch signaling mechanisms at play during skeletal development, disease, and repair. Additional studies are also focused on identifying and understanding the molecular mechanisms underlying various congenital skeletal pathologies, including Multiple Herediatry Exostoses (MHE) and Preaxial Polydactyly (PPD).

Current Appointments & Affiliations

Associate Professor in Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2018
Associate Professor in Cell Biology, Cell Biology, Basic Science Departments 2015
Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021

Contact Information

450 Research Drive, LSRC B321c, DUMC 91009, Durham, NC 27710
91009, Durham, NC 27710
matthew.hilton@duke.edu (919) 613-9761
The Hilton Laboratory

Background
Education, Training, & Certifications
- Ph.D., University of Houston 2004
Previous Appointments & Affiliations
- Associate Professor in Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2015 - 2018
- Instructor, Temporary in the Department of Orthopaedic Surgery, Orthopaedic Surgery, Clinical Science Departments 2014 - 2015
Expertise
Subject Headings
Global Scholarship
- Research
  - United States of America (Country)
Research
Selected Grants
- Targeting the HIF-2 Signaling Pathway as a Radioprotective Strategy for Bone awarded by National Institutes of Health 2022 - 2027
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Resorbable, Phsophorylated Poly(ester urea) Surgical Adhesive to Enhance Fracture Healing awarded by National Institutes of Health 2021 - 2026
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2024
- CaMKK2 Signaling in Osteoarthritis awarded by Indiana University 2020 - 2024
- Notch Signaling in Endochondral Bone Development awarded by National Institutes of Health 2018 - 2023
- Notch Signaling in non-myogenic mesenchymal cells regulates muscle development awarded by National Institutes of Health 2020 - 2023
- Notch Signaling in Joint Cartilage Maintenance and Arthritis awarded by National Institutes of Health 2012 - 2022
- Zeiss Lightsheet Upgrade to Expand Imaging Capabilities awarded by National Institutes of Health 2021 - 2022
- The role of proline metabolism during osteoblast differentiation and bone formation awarded by University of Texas Southwestern Medical Center 2021
- Role of Glutamine Metabolism during Osteoblast Differentiation and Bone Formation awarded by University of Texas Southwestern Medical Center 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Investigation of the roles for CaVa1.2 in non-excitable tissue during development awarded by Weill Medical College of Cornell University 2016 - 2017
- Study of Osteoblast Regulation in TNF-Mediated Bone Loss awarded by University of Rochester 2014 - 2016
- Notch Signaling in Cartilage Development awarded by National Institutes of Health 2010 - 2015
Publications & Artistic Works
Selected Publications
- Books
  - Hilton, M. J. (2021). Preface (Vol. 2230, p. v).
  - Hilton, M. J. (Ed.). (2014). Skeletal Development and Repair. Humana Press. https://doi.org/10.1007/978-1-62703-989-5
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- Academic Articles
  - Rabjohns, E. M., Rampersad, R. R., Ghosh, A., Hurst, K., Eudy, A. M., Brozowski, J. M., … Tarrant, T. K. (2023). Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone. Cells, 12(7). https://doi.org/10.3390/cells12070981
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  - Wang, N., Wen, Q., Maharjan, S., Mirando, A. J., Qi, Y., Hilton, M. J., & Spritzer, C. E. (2022). Magic angle effect on diffusion tensor imaging in ligament and brain. Magn Reson Imaging, 92, 243–250. https://doi.org/10.1016/j.mri.2022.06.008
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  - Liao, Y., Ren, Y., Luo, X., Mirando, A. J., Long, J. T., Leinroth, A., … Hilton, M. J. (2022). Interleukin-6 signaling mediates cartilage degradation and pain in posttraumatic osteoarthritis in a sex-specific manner. Sci Signal, 15(744), eabn7082. https://doi.org/10.1126/scisignal.abn7082
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  - Ruderman, L., Leinroth, A., Rueckert, H., Tabarestani, T., Baker, R., Levin, J., … Anakwenze, O. (2022). Histologic Differences in Human Rotator Cuff Muscle Based on Tear Characteristics. J Bone Joint Surg Am, 104(13), 1148–1156. https://doi.org/10.2106/JBJS.21.01304
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  - Leinroth, A. P., Mirando, A. J., Rouse, D., Kobayahsi, Y., Tata, P. R., Rueckert, H. E., … Hilton, M. J. (2022). Identification of distinct non-myogenic skeletal-muscle-resident mesenchymal cell populations. Cell Rep, 39(6), 110785. https://doi.org/10.1016/j.celrep.2022.110785
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  - Long, J. T., Leinroth, A., Liao, Y., Ren, Y., Mirando, A. J., Nguyen, T., … Hilton, M. J. (2022). Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development. Elife, 11. https://doi.org/10.7554/eLife.76932
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  - Brozowski, J. M., Timoshchenko, R. G., Serafin, D. S., Allyn, B., Koontz, J., Rabjohns, E. M., … Tarrant, T. K. (2022). G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation. Stem Cell Res Ther, 13(1), 37. https://doi.org/10.1186/s13287-022-02715-4
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  - Sharma, D., Mirando, A. J., Leinroth, A., Long, J. T., Karner, C. M., & Hilton, M. J. (2021). HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly. Plos Genet, 17(12), e1009982. https://doi.org/10.1371/journal.pgen.1009982
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  - Abar, B., Kelly, C., Pham, A., Allen, N., Barber, H., Kelly, A., … Adams, S. B. (2021). Effect of surface topography on in vitro osteoblast function and mechanical performance of 3D printed titanium. J Biomed Mater Res A, 109(10), 1792–1802. https://doi.org/10.1002/jbm.a.37172
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  - Liao, Y., Ren, Y., Luo, X., Long, J. T., Mirando, A. J., Leinroth, A. P., … Hilton, M. J. (2021). Interleukin-6 Signaling Mediates Cartilage Degradation and Pain in Post-Traumatic Osteoarthritis. https://doi.org/10.1101/2021.09.08.459303
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  - Wang, K., Donnelly, C. R., Jiang, C., Liao, Y., Luo, X., Tao, X., … Ji, R.-R. (2021). STING suppresses bone cancer pain via immune and neuronal modulation. Nat Commun, 12(1), 4558. https://doi.org/10.1038/s41467-021-24867-2
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2021). Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. Cancer Res, 81(14), 3777–3790. https://doi.org/10.1158/0008-5472.CAN-20-2823
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  - Guo, W., Spiller, K. V., Tang, J., Karner, C. M., Hilton, M. J., & Wu, C. (2021). Hypoxia depletes contaminating CD45+ hematopoietic cells from murine bone marrow stromal cell (BMSC) cultures: Methods for BMSC culture purification. Stem Cell Res, 53, 102317. https://doi.org/10.1016/j.scr.2021.102317
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  - Liao, Y., Long, J. T., Gallo, C. J. R., Mirando, A. J., & Hilton, M. J. (2021). Isolation and Culture of Murine Primary Chondrocytes: Costal and Growth Plate Cartilage. Methods Mol Biol, 2230, 415–423. https://doi.org/10.1007/978-1-0716-1028-2_25
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  - Mirando, A. J., & Hilton, M. J. (2021). Demineralized Murine Skeletal Histology. Methods Mol Biol, 2230, 283–302. https://doi.org/10.1007/978-1-0716-1028-2_16
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  - Sharma, D., Hilton, M. J., & Karner, C. M. (2021). Whole Mount In Situ Hybridization in Murine Tissues. Methods Mol Biol, 2230, 367–376. https://doi.org/10.1007/978-1-0716-1028-2_22
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  - Wang, K., Donnelly, C., Jiang, C., Liao, Y., Tao, X., Bang, S., … Ji, R.-R. (2021). STING suppresses cancer pain via immune and neuronal modulation. https://doi.org/10.1101/2021.01.18.426944
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  - Wang, N., Mirando, A. J., Cofer, G., Qi, Y., Hilton, M. J., & Johnson, G. A. (2020). Characterization complex collagen fiber architecture in knee joint using high-resolution diffusion imaging. Magn Reson Med, 84(2), 908–919. https://doi.org/10.1002/mrm.28181
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  - Wang, K., Gu, Y., Liao, Y., Bang, S., Donnelly, C. R., Chen, O., … Ji, R.-R. (2020). PD-1 blockade inhibits osteoclast formation and murine bone cancer pain. J Clin Invest, 130(7), 3603–3620. https://doi.org/10.1172/JCI133334
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  - Sharma, D., Mirando, A., Leinroth, A., Long, J., Karner, C., & Hilton, M. (2020). HES1 is a Critical Mediator of the SHH-GLI3 Axis in Regulating Digit Number. https://doi.org/10.1101/2020.06.17.158501
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  - Liu, Z., Easson, G. W. D., Zhao, J., Makki, N., Ahituv, N., Hilton, M. J., … Gray, R. S. (2019). Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice. Plos Genet, 15(10), e1008096. https://doi.org/10.1371/journal.pgen.1008096
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  - Catheline, S. E., Hoak, D., Chang, M., Ketz, J. P., Hilton, M. J., Zuscik, M. J., & Jonason, J. H. (2019). Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice. J Bone Miner Res, 34(9), 1676–1689. https://doi.org/10.1002/jbmr.3737
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  - Cao, C., Oswald, A. B., Fabella, B. A., Ren, Y., Rodriguiz, R., Trainor, G., … Pitt, G. S. (2019). The CaV1.2 L-type calcium channel regulates bone homeostasis in the middle and inner ear. Bone, 125, 160–168. https://doi.org/10.1016/j.bone.2019.05.024
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  - Wang, N., Mirando, A. J., Cofer, G., Qi, Y., Hilton, M. J., & Johnson, G. A. (2019). Diffusion tractography of the rat knee at microscopic resolution. Magn Reson Med, 81(6), 3775–3786. https://doi.org/10.1002/mrm.27652
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  - Yu, Y., Newman, H., Shen, L., Sharma, D., Hu, G., Mirando, A. J., … Karner, C. M. (2019). Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells. Cell Metab, 29(4), 966-978.e4. https://doi.org/10.1016/j.cmet.2019.01.016
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  - Tsushima, H., Tang, Y. J., Puviindran, V., Hsu, S.-H., Nadesan, P., Yu, C., … Alman, B. A. (2018). Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. Development, 145(13). https://doi.org/10.1242/dev.162396
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  - Zheng, Y., Liu, C., Ni, L., Liu, Z., Mirando, A. J., Lin, J., … Chen, J. (2018). Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration. J Cell Physiol, 233(7), 5431–5440. https://doi.org/10.1002/jcp.26385
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  - Cao, C., Ren, Y., Barnett, A. S., Mirando, A. J., Rouse, D., Mun, S. H., … Pitt, G. S. (2017). Increased Ca2+ signaling through CaV1.2 promotes bone formation and prevents estrogen deficiency-induced bone loss. Jci Insight, 2(22). https://doi.org/10.1172/jci.insight.95512
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  - Lawal, R. A., Zhou, X., Batey, K., Hoffman, C. M., Georger, M. A., Radtke, F., … Calvi, L. M. (2017). The Notch Ligand Jagged1 Regulates the Osteoblastic Lineage by Maintaining the Osteoprogenitor Pool. J Bone Miner Res, 32(6), 1320–1331. https://doi.org/10.1002/jbmr.3106
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  - Dar, Q.-A., Schott, E. M., Catheline, S. E., Maynard, R. D., Liu, Z., Kamal, F., … Zuscik, M. J. (2017). Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis. Plos One, 12(4), e0174705. https://doi.org/10.1371/journal.pone.0174705
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  - Zhang, H., Sun, W., Li, X., Wang, M., Boyce, B. F., Hilton, M. J., & Xing, L. (2016). Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation. Bone, 90, 80–89. https://doi.org/10.1016/j.bone.2016.06.003
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  - Hamada, D., Maynard, R., Schott, E., Drinkwater, C. J., Ketz, J. P., Kates, S. L., … Mooney, R. A. (2016). Suppressive Effects of Insulin on Tumor Necrosis Factor-Dependent Early Osteoarthritic Changes Associated With Obesity and Type 2 Diabetes Mellitus. Arthritis Rheumatol, 68(6), 1392–1402. https://doi.org/10.1002/art.39561
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  - Rutkowski, T. P., Kohn, A., Sharma, D., Ren, Y., Mirando, A. J., & Hilton, M. J. (2016). HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development. J Cell Sci, 129(11), 2145–2155. https://doi.org/10.1242/jcs.181271
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  - Shang, X., Wang, J., Luo, Z., Wang, Y., Morandi, M. M., Marymont, J. V., … Dong, Y. (2016). Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest. Sci Rep, 6, 25594. https://doi.org/10.1038/srep25594
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  - Liu, Z., Ren, Y., Mirando, A. J., Wang, C., Zuscik, M. J., O’Keefe, R. J., & Hilton, M. J. (2016). Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance. Osteoarthritis Cartilage, 24(4), 740–751. https://doi.org/10.1016/j.joca.2015.10.015
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  - Wang, C., Inzana, J. A., Mirando, A. J., Ren, Y., Liu, Z., Shen, J., … Hilton, M. J. (2016). NOTCH signaling in skeletal progenitors is critical for fracture repair. J Clin Invest, 126(4), 1471–1481. https://doi.org/10.1172/JCI80672
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  - Zhang, Y., Sheu, T.-J., Hoak, D., Shen, J., Hilton, M. J., Zuscik, M. J., … O’Keefe, R. J. (2016). CCN1 Regulates Chondrocyte Maturation and Cartilage Development. J Bone Miner Res, 31(3), 549–559. https://doi.org/10.1002/jbmr.2712
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  - Wang, C., Shen, J., Yukata, K., Inzana, J. A., O’Keefe, R. J., Awad, H. A., & Hilton, M. J. (2015). Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation. Bone, 73, 77–89. https://doi.org/10.1016/j.bone.2014.12.007
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  - Qiu, T., Xian, L., Crane, J., Wen, C., Hilton, M., Lu, W., … Cao, X. (2015). PTH receptor signaling in osteoblasts regulates endochondral vascularization in maintenance of postnatal growth plate. J Bone Miner Res, 30(2), 309–317. https://doi.org/10.1002/jbmr.2327
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  - Kohn, A., Rutkowski, T. P., Liu, Z., Mirando, A. J., Zuscik, M. J., O’Keefe, R. J., & Hilton, M. J. (2015). Notch signaling controls chondrocyte hypertrophy via indirect regulation of Sox9. Bone Res, 3, 15021. https://doi.org/10.1038/boneres.2015.21
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  - Dong, Y., Long, T., Wang, C., Mirando, A. J., Chen, J., O’Keefe, R. J., & Hilton, M. J. (2014). NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine. Stem Cells Transl Med, 3(12), 1456–1466. https://doi.org/10.5966/sctm.2014-0034
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  - Jones, K. B., Pacifici, M., & Hilton, M. J. (2014). Multiple hereditary exostoses (MHE): elucidating the pathogenesis of a rare skeletal disorder through interdisciplinary research. Connect Tissue Res, 55(2), 80–88. https://doi.org/10.3109/03008207.2013.867957
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  - Long, T., Zhu, Z., Awad, H. A., Schwarz, E. M., Hilton, M. J., & Dong, Y. (2014). The effect of mesenchymal stem cell sheets on structural allograft healing of critical sized femoral defects in mice. Biomaterials, 35(9), 2752–2759. https://doi.org/10.1016/j.biomaterials.2013.12.039
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  - Brown, M. L., Yukata, K., Farnsworth, C. W., Chen, D.-G., Awad, H., Hilton, M. J., … Zuscik, M. J. (2014). Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus. Plos One, 9(6), e99656. https://doi.org/10.1371/journal.pone.0099656
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  - Hilton, M. J. (2014). Preface. Methods in Molecular Biology, 1130. https://doi.org/10.1007/978-1-62703-989_5
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  - Mack, S. A., Maltby, K. M., & Hilton, M. J. (2014). Demineralized murine skeletal histology. Methods Mol Biol, 1130, 165–183. https://doi.org/10.1007/978-1-62703-989-5_12
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  - Mack, S. A., Maltby, K. M., & Hilton, M. J. (2014). Demineralized murine skeletal histology. Methods in Molecular Biology, 1130, 165–183. https://doi.org/10.1007/978-1-62703-989-5-12
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  - Mirando, A. J., Dong, Y., Kim, J., & Hilton, M. J. (2014). Isolation and culture of murine primary chondrocytes. Methods Mol Biol, 1130, 267–277. https://doi.org/10.1007/978-1-62703-989-5_20
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  - Mirando, A. J., Dong, Y., Kim, J., & Hilton, M. J. (2014). Isolation and culture of murine primary chondrocytes. Methods in Molecular Biology, 1130, 267–277. https://doi.org/10.1007/978-1-62703-989-5-20
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  - Rutkowsky, T., Sharma, D., & Hilton, M. J. (2014). Whole-mount in situ hybridization on murine skeletogenic tissues. Methods Mol Biol, 1130, 193–201. https://doi.org/10.1007/978-1-62703-989-5_14
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  - Rutkowsky, T., Sharma, D., & Hilton, M. J. (2014). Whole-mount in situ hybridization on murine skeletogenic tissues. Methods in Molecular Biology, 1130, 193–201. https://doi.org/10.1007/978-1-62703-989-5-14
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  - Gao, L., Sheu, T.-J., Dong, Y., Hoak, D. M., Zuscik, M. J., Schwarz, E. M., … Jonason, J. H. (2013). TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages. J Cell Sci, 126(Pt 24), 5704–5713. https://doi.org/10.1242/jcs.135483
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  - Mirando, A. J., Liu, Z., Moore, T., Lang, A., Kohn, A., Osinski, A. M., … Hilton, M. J. (2013). RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance. Arthritis Rheum, 65(10), 2623–2633. https://doi.org/10.1002/art.38076
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  - Ju, Y., Li, J., Xie, C., Ritchlin, C. T., Xing, L., Hilton, M. J., & Schwarz, E. M. (2013). Troponin T3 expression in skeletal and smooth muscle is required for growth and postnatal survival: characterization of Tnnt3(tm2a(KOMP)Wtsi) mice. Genesis, 51(9), 667–675. https://doi.org/10.1002/dvg.22407
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  - Chen, T., Hilton, M. J., Brown, E. B., Zuscik, M. J., & Awad, H. A. (2013). Engineering superficial zone features in tissue engineered cartilage. Biotechnol Bioeng, 110(5), 1476–1486. https://doi.org/10.1002/bit.24799
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  - Dao, D. Y., Jonason, J. H., Zhang, Y., Hsu, W., Chen, D., Hilton, M. J., & O’Keefe, R. J. (2012). Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development. J Bone Miner Res, 27(8), 1680–1694. https://doi.org/10.1002/jbmr.1639
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  - Kim, K.-O., Sampson, E. R., Maynard, R. D., O’Keefe, R. J., Chen, D., Drissi, H., … Zuscik, M. J. (2012). Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes. J Cell Biochem, 113(6), 2156–2166. https://doi.org/10.1002/jcb.24089
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  - Kohn, A., Dong, Y., Mirando, A. J., Jesse, A. M., Honjo, T., Zuscik, M. J., … Hilton, M. J. (2012). Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development. Development, 139(6), 1198–1212. https://doi.org/10.1242/dev.070649
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  - Shu, B., Zhang, M., Xie, R., Wang, M., Jin, H., Hou, W., … Chen, D. (2011). BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. J Cell Sci, 124(Pt 20), 3428–3440. https://doi.org/10.1242/jcs.083659
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  - Sampson, E. R., Hilton, M. J., Tian, Y., Chen, D., Schwarz, E. M., Mooney, R. A., … Zuscik, M. J. (2011). Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. Sci Transl Med, 3(101), 101ra93. https://doi.org/10.1126/scitranslmed.3002214
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  - Papuga, M. O., Kwok, E., You, Z., Rubery, P. T., Dougherty, P. E., Pryhuber, G., … Schwarz, E. M. (2011). TNF is required for the induction but not the maintenance of compression-induced BME signals in murine tail vertebrae: limitations of anti-TNF therapy for degenerative disc disease. J Orthop Res, 29(9), 1367–1374. https://doi.org/10.1002/jor.21370
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  - Sampson, E. R., Beck, C. A., Ketz, J., Canary, K. L., Hilton, M. J., Awad, H., … Zuscik, M. J. (2011). Establishment of an index with increased sensitivity for assessing murine arthritis. J Orthop Res, 29(8), 1145–1151. https://doi.org/10.1002/jor.21368
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  - Katzel, E. B., Wolenski, M., Loiselle, A. E., Basile, P., Flick, L. M., Langstein, H. N., … O’Keefe, R. J. (2011). Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing. J Orthop Res, 29(5), 684–693. https://doi.org/10.1002/jor.21235
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  - Papuga, M. O., Proulx, S. T., Kwok, E., You, Z., Rubery, P. T., Dougherty, P. E., … Schwarz, E. M. (2010). Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity. J Orthop Res, 28(9), 1220–1228. https://doi.org/10.1002/jor.21103
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  - Gunnell, L. M., Jonason, J. H., Loiselle, A. E., Kohn, A., Schwarz, E. M., Hilton, M. J., & O’Keefe, R. J. (2010). TAK1 regulates cartilage and joint development via the MAPK and BMP signaling pathways. J Bone Miner Res, 25(8), 1784–1797. https://doi.org/10.1002/jbmr.79
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  - Dong, Y., Jesse, A. M., Kohn, A., Gunnell, L. M., Honjo, T., Zuscik, M. J., … Hilton, M. J. (2010). RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development, 137(9), 1461–1471. https://doi.org/10.1242/dev.042911
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  - Dao, D. Y., Yang, X., Flick, L. M., Chen, D., Hilton, M. J., & O’Keefe, R. J. (2010). Axin2 regulates chondrocyte maturation and axial skeletal development. J Orthop Res, 28(1), 89–95. https://doi.org/10.1002/jor.20954
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  - Christopher, M. J., Liu, F., Hilton, M. J., Long, F., & Link, D. C. (2009). Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization. Blood, 114(7), 1331–1339. https://doi.org/10.1182/blood-2008-10-184754
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  - Crane, D. P., Gromov, K., Li, D., Søballe, K., Wahnes, C., Büchner, H., … Schwarz, E. M. (2009). Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis. J Orthop Res, 27(8), 1008–1015. https://doi.org/10.1002/jor.20847
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  - Metcalf, J. A., Zhang, Y., Hilton, M. J., Long, F., & Ponder, K. P. (2009). Mechanism of shortened bones in mucopolysaccharidosis VII. Mol Genet Metab, 97(3), 202–211. https://doi.org/10.1016/j.ymgme.2009.03.005
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  - Yin, Y., White, A. C., Huh, S.-H., Hilton, M. J., Kanazawa, H., Long, F., & Ornitz, D. M. (2008). An FGF-WNT gene regulatory network controls lung mesenchyme development. Dev Biol, 319(2), 426–436. https://doi.org/10.1016/j.ydbio.2008.04.009
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  - Wu, X., Tu, X., Joeng, K. S., Hilton, M. J., Williams, D. A., & Long, F. (2008). Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling. Cell, 133(2), 340–353. https://doi.org/10.1016/j.cell.2008.01.052
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  - Bai, S., Kopan, R., Zou, W., Hilton, M. J., Ong, C.-T., Long, F., … Teitelbaum, S. L. (2008). NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem, 283(10), 6509–6518. https://doi.org/10.1074/jbc.M707000200
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  - Hilton, M. J., Tu, X., Wu, X., Bai, S., Zhao, H., Kobayashi, T., … Long, F. (2008). Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. Nat Med, 14(3), 306–314. https://doi.org/10.1038/nm1716
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  - Hilton, M. J., Tu, X., & Long, F. (2007). Tamoxifen-inducible gene deletion reveals a distinct cell type associated with trabecular bone, and direct regulation of PTHrP expression and chondrocyte morphology by Ihh in growth region cartilage. Dev Biol, 308(1), 93–105. https://doi.org/10.1016/j.ydbio.2007.05.011
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  - Hilton, M. J., & Wells, D. E. (2007). Chromosome 8. https://doi.org/10.1002/9780470015902.a0005817.pub2
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  - Hilton, M. J., Tu, X., Cook, J., Hu, H., & Long, F. (2005). Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development. Development, 132(19), 4339–4351. https://doi.org/10.1242/dev.02025
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  - Hilton, M. J., Gutiérrez, L., Martinez, D. A., & Wells, D. E. (2005). EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development. Bone, 36(3), 379–386. https://doi.org/10.1016/j.bone.2004.09.025
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  - Hu, H., Hilton, M. J., Tu, X., Yu, K., Ornitz, D. M., & Long, F. (2005). Sequential roles of Hedgehog and Wnt signaling in osteoblast development. Development, 132(1), 49–60. https://doi.org/10.1242/dev.01564
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  - Hilton, M. J., Sawyer, J. M., Gutiérrez, L., Hogart, A., Kung, T. C., & Wells, D. E. (2002). Analysis of novel and recurrent mutations responsible for the tricho-rhino-phalangeal syndromes. J Hum Genet, 47(3), 103–106. https://doi.org/10.1007/s100380200010
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  - Hilton, M. J., Gutiérrez, L., Zhang, L., Moreno, P. A., Reddy, M., Brown, N., … Wells, D. E. (2001). An integrated physical map of 8q22-q24: use in positional cloning and deletion analysis of Langer-Giedion syndrome. Genomics, 71(2), 192–199. https://doi.org/10.1006/geno.2000.6438
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- Book Sections
  - Hilton, M. J. (2021). Skeletal Development and Repair Methods and Protocols Second Edition Preface. In SKELETAL DEVELOPMENT AND REPAIR, 2 EDITION (Vol. 2230, pp. V–V).
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  - Ren, Y., Liao, Y., & Hilton, M. J. (2020). Notch signaling in cartilage development and disease. In Encyclopedia of Bone Biology (pp. 589–604).
  - Hilton, M. J., & Lyons, K. M. (2019). Application of genetically modified animals in bone research. In Principles of Bone Biology (pp. 1787–1800). https://doi.org/10.1016/B978-0-12-814841-9.00077-4
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  - Karner, C. M., & Hilton, M. J. (2018). Endochondral ossification. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism (pp. 12–19). https://doi.org/10.1002/9781119266594.ch2
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  - Hilton, M. J. (2014). Skeletal Development and Repair Methods and Protocols Preface. In SKELETAL DEVELOPMENT AND REPAIR: METHODS AND PROTOCOLS (Vol. 1130, pp. V–V).
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  - Rutkowsky, T., Sharma, D., & Hilton, M. J. (2014). Whole-Mount In Situ Hybridization on Murine Skeletogenic Tissues (vol 1130, pg 193, 2014). In SKELETAL DEVELOPMENT AND REPAIR: METHODS AND PROTOCOLS (Vol. 1130, pp. E1–E1).
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- Other Articles
  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Supplementary Table 4 from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.22428720.v1
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Supplementary Table 2 from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.22428726
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Supplementary Table 6 from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.22428711
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Data from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.c.6513108.v1
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Supplementary Figures from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.22428732
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Supplementary Table 1 from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.22428729.v1
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Supplementary Table 4 from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.22428720
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Supplementary Table 6 from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.22428711.v1
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Supplementary Table 3 from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.22428723.v1
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Supplementary Table 3 from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.22428723
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Supplementary Table 1 from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.22428729
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Supplementary Table 2 from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.22428726.v1
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Supplementary Table 5 from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.22428714.v1
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Supplementary Figures from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.22428732.v1
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  - Lee, C.-L., Brock, K. D., Hasapis, S., Zhang, D., Sibley, A. B., Qin, X., … Kirsch, D. G. (2023). Supplementary Table 5 from Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. https://doi.org/10.1158/0008-5472.22428714
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- Conference Papers
  - Roston, R. A., Mirando, A. J., McLellan, W. A., Pabst, D. A., Hilton, M. J., & Roth, V. L. (2021). Sutural structure in a telescoped skull: the maxillo-frontal suture in Tursiops truncatus. In Integrative and Comparative Biology (Vol. 61, pp. E764–E764).
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  - Cao, C., Ren, Y., Mirando, A. J., Barnett, A., Rouse, D., Mun, S. H., … Pitt, G. S. (2017). Increased Ca2+signaling through altered CaV1.2 L-type Ca2+channel activity promotes bone formation and prevents estrogen deficiency-induced bone loss. In Journal of Bone and Mineral Research (Vol. 32, pp. S31–S31). Denver, CO: WILEY.
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  - Kamal, F., Schott, E. M., Carlson, E. L., El-Quadi, M., Le Bleu, H. K., Hilton, M. J., … Zuscik, M. J. (2017). Chondrocyte PTH1R anti-hypertrophic signaling is essential for articular cartilage maintenance and protection post trauma. In Osteoarthritis and Cartilage (Vol. 25, pp. S13–S14). Elsevier BV. https://doi.org/10.1016/j.joca.2017.02.037
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  - Dart, Q.-A., Maynard, R. D., Liu, Z., Schott, E. M., Catheline, S., Mooney, R. A., … Zuscik, M. J. (2016). ORAL HYDROLYZED TYPE 1 COLLAGEN INDUCES CHONDROREGENERATION AND INHIBITS SYNOVIAL INFLAMMATION IN MURINE POSTTRAUMATIC OSTEOARTHRITIS. In Osteoarthritis and Cartilage (Vol. 24, pp. S532–S533). Amsterdam, NETHERLANDS: ELSEVIER SCI LTD.
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  - Hilton, M. J. (2013). Mouse models of joint disorders. In Osteoarthritis and Cartilage (Vol. 21, pp. S6–S6). Elsevier BV. https://doi.org/10.1016/j.joca.2013.02.030
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  - Metcalf, J. A., Zhang, Y., Hilton, M. J., Long, F., & Ponder, K. P. (2009). Mechanism of Shortened Bones in Mucopolysaccharidosis VII. In Molecular Therapy (Vol. 17, pp. S343–S343). San Diego, CA: NATURE PUBLISHING GROUP.
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  - Christopher, M. J., Hilton, M. J., Long, F., & Link, D. C. (2007). Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-incluced mobilization. In Blood (Vol. 110, pp. 72A-72A). Atlanta, GA: AMER SOC HEMATOLOGY.
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  - Hilton, M. J., Bai, S., Kopan, R., Ross, F. P., Teitelbaum, S. L., & Long, F. (2006). Notch signaling represses osteoblast activity but promotes osteoclast function in vivo. In Journal of Bone and Mineral Research (Vol. 21, pp. S66–S66). Philadelphia, PA: AMER SOC BONE & MINERAL RES.
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  - Hilton, M. J., & Long, F. (2005). Temporal control of gene deletion in the cartilage using a tamoxifen inducible Cre transgenic mouse. In Journal of Bone and Mineral Research (Vol. 20, pp. S39–S39). Nashville, TN: AMER SOC BONE & MINERAL RES.
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Teaching & Mentoring
Recent Courses
- CELLBIO 493: Research Independent Study 2023
- CELLBIO 493: Research Independent Study 2021
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- Standing Member. Skeletal Biology, Development, and Disease Study Section. NIH. 2015 - 2019 2015 - 2019

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