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Matthew James Hilton

Professor in Orthopaedic Surgery
Orthopaedic Surgery
450 Research Drive, LSRC B321C, DUMC 91009, Durham, NC 27710
91009, Durham, NC 27710

Scholarly Works - Book sections


Notch Signaling in Cartilage Development and Disease

Book section · January 1, 2020 The Notch signaling pathway regulates cell fate determination, proliferation, differentiation, and apoptosis in many tissues coordinating key aspects of development, maintenance, and disease progression. Recently, the Notch pathway has been identified as a ... Full text Cite

Application of genetically modified animals in bone research

Book section · January 1, 2019 Genetically modified mice have had an enormous impact on our understanding of skeletal development, maintenance, and disease. Publicly supported efforts to generate and phenotype genes in the mouse have greatly expanded the ease of identifying and characte ... Full text Cite

Endochondral ossification

Book section · January 1, 2018 The endochondral ossification, the process responsible for generating most of the skeleton, requires a cartilage intermediate before forming bone. This chapter discusses the major cellular events of endochondral ossification: chondrogenesis, chondrocyte hy ... Full text Cite