Matthew James Hilton

Journal article Stem Cells Transl Med · December 2014 Featured Publication Human bone marrow-derived stromal/stem cells (BMSCs) have great therapeutic potential for treating skeletal disease and facilitating skeletal repair, although maintaining their multipotency and expanding these cells ex vivo have proven difficult. Because m ... Full text Link to item Cite

Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development.

Journal article Development · March 2012 Featured Publication The Notch signaling pathway has emerged as an important regulator of endochondral bone formation. Although recent studies have examined the role of Notch in mesenchymal and chondro-osteo progenitor cell populations, there has yet to be a true examination o ... Full text Link to item Cite

RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.

Journal article Development · May 2010 Featured Publication The Notch pathway has recently been implicated in mesenchymal progenitor cell (MPC) differentiation from bone marrow-derived progenitors. However, whether Notch regulates MPC differentiation in an RBPjkappa-dependent manner, specifies a particular MPC cell ... Full text Link to item Cite

Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation.

Journal article Nat Med · March 2008 Featured Publication Postnatal bone marrow houses mesenchymal progenitor cells that are osteoblast precursors. These cells have established therapeutic potential, but they are difficult to maintain and expand in vitro, presumably because little is known about the mechanisms co ... Full text Link to item Cite