Scholars@Duke
Matthew Hirschey

Matthew Hirschey

Associate Professor of Medicine
Medicine, Endocrinology, Metabolism, and Nutrition
104775, Room 50-201, Durham, NC 27701
300 N. Duke Street, 50-201, Durham, NC 27701

Scholarly Works - Book sections

Reactive Acyl-CoA Species and Deacylation by the Mitochondrial Sirtuins

Book section · April 25, 2018 The sirtuins are a family of nicotinamide adenine dinucleotide (NAD+)-dependent enzymes that remove acyl-lysine modifications from a variety of proteins, thereby controlling a myriad of cellular processes. In mitochondria, reactive acyl-CoA spec ... Full text Cite

Sirtuins

Book section · September 28, 2015 The mammalian sirtuins are a family of seven NAD+-dependent deacetylase enzymes that regulate a wide range of hepatic functions. Altered sirtuin expression in model organisms results in pleiotropic hepatic dysfunction. Furthermore, altered sirtuin expressi ... Full text Cite