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Matthew William Luedke

Associate Professor of Neurology
Hospital Neurology
2424 Erwin Rd, DUMC 2720, Dept of Neurology, Durham, NC 27710-2720
2424 Erwin Rd Suite 1001, DUMC 2720, Durham, NC 27705-3858

Overview


I have diverse research interests and collaborations.  Clinical research interests include epilepsy quality-of-life interventions and therapeutics and acute care neurological issues like post-cardiac arrest management and quality-of-care issues.  I work with the Duke hyperbaric chamber team on clinical neurophysiological monitoring of ketone-related research.

Current Appointments & Affiliations


Associate Professor of Neurology · 2023 - Present Hospital Neurology, Neurology
Division Chief, Hospital Neurology in the Department of Neurology · 2019 - Present Neurology, Clinical Science Departments

Recent Publications


Usability, Face Validity, Feasibility, and Reliability of 3 Neurocritical Care Electronic Clinical Quality Measures.

Journal Article Neurol Clin Pract · August 2025 BACKGROUND AND OBJECTIVES: The field of neurology lacks neurocritical care (NCC) quality measures because of the complexity of neurologic disorders and challenges in data collection, hindering efforts to assess care quality and improve patient outcomes. Th ... Full text Link to item Cite

Of Hearth and Home: Professional Wellness After Hours.

Journal Article Epilepsy Curr · 2025 Burnout is a prevalent problem in the contemporary practice of medicine. Defined by the Agency for Healthcare Research and Quality as, "a long-term stress reaction marked by emotional exhaustion, depersonalization, and a lack of sense of personal accomplis ... Full text Link to item Cite

Association Between Neighborhood Socioeconomic Status and 30-Day Mortality and Readmission for Patients With Common Neurologic Conditions.

Journal Article Neurology · April 25, 2023 BACKGROUND AND OBJECTIVES: Patients of low individual socioeconomic status (SES) are at a greater risk of unfavorable health outcomes. However, the association between neighborhood socioeconomic deprivation and health outcomes for patients with neurologic ... Full text Link to item Cite
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Recent Grants


Ketone Ester Supplement for CNSOT Mitigation

ResearchCo Investigator · Awarded by Naval Sea Systems Command · 2022 - 2025

Ketogenic Diet for Reduction of CNS Oxygen Toxicity Symptoms in Working Divers - Clin 0201 (Salary)

ResearchCo Investigator · Awarded by Naval Sea Systems Command · 2017 - 2021

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Education, Training & Certifications


Baylor, College of Medicine · 2010 M.D.