Scholars@Duke
Matthew Stuart McKinney

Matthew Stuart McKinney

Associate Professor of Medicine
Medicine, Hematologic Malignancies and Cellular Therapy
matthew.mckinney@duke.edu
Box 3961 Med Ctr, Durham, NC 27710
2400 Pratt Street, Suite 5000, Durham, NC 27710

Scholarly Works - Journal articles

Infectious Complications of CD19-targeted Chimeric Antigen Receptor T-cell Therapy: a Multicenter Cohort Study.

Journal article Open Forum Infect Dis · July 2026 BACKGROUND: Our understanding of the epidemiology of and risk factors for postchimeric antigen receptor T-cell therapy (CART) infections is largely based on data from single-center studies with small sample sizes. METHODS: This is a multicenter, cohort stu ... Full text Link to item Cite

Respiratory Viral Infections Following CD19 CAR T-Cell Therapy.

Journal article J Med Virol · May 2026 Respiratory viral infections (RVI) are an important infectious complication after chimeric antigen receptor (CAR) T-cell therapy. However, the epidemiology of RVI following CAR T-cell therapy and their risk factors are not well defined. To describe the inc ... Full text Link to item Cite

Safety and activity of pirtobrutinib in patients with relapsed or refractory Waldenström macroglobulinaemia: 5-year follow-up of the open-label, multicentre, phase 1/2 BRUIN trial.

Journal article Lancet Haematol · May 2026 BACKGROUND: Covalent Bruton tyrosine kinase (BTK) inhibitors have advanced the treatment of Waldenström macroglobulinaemia; however, the occurrence of progression, intolerance, and acquired resistance are not fully understood. We aim to report on the safet ... Full text Link to item Cite

A Phase 2, Open-Label, Multicenter Study of the Safety and Efficacy of TAK-007 in Adult Patients with Relapsed/Refractory B-cell Non-Hodgkin Lymphoma.

Journal article Blood Cancer Discov · April 17, 2026 In relapsed/refractory large B-cell lymphoma (LBCL), chimeric antigen receptor (CAR)-natural killer (NK) cell therapies offer potential advantages over CAR-T-cell therapies, including off-the-shelf availability and scalable manufacturing. We performed a ph ... Full text Link to item Cite

How far should adjacent pan traps be placed for bee sampling?

Journal article Entomological Science · December 2024 AbstractAmong several methods of active and passive sampling bees (Hymenoptera: Apoidea), pan traps, also known as bee bowls, are commonly utilized for their efficiency and as a means of avoiding collector bias. When compar ... Full text Cite

Expansion of an Academic Molecular Tumor Board to Enhance Access to Biomarker-Driven Trials and Therapies in the Rural Southeastern United States.

Journal article Curr Oncol · November 16, 2024 Targeting tumor-specific molecular alterations has shown significant clinical benefit. Molecular tumor boards (MTBs) connect cancer patients with personalized treatments and clinical trials. However, rural cancer centers often have limited access to MTB ex ... Full text Link to item Cite

Pirtobrutinib, a highly selective, non-covalent (reversible) BTK inhibitor in patients with B-cell malignancies: analysis of the Richter transformation subgroup from the multicentre, open-label, phase 1/2 BRUIN study.

Journal article Lancet Haematol · September 2024 BACKGROUND: Richter transformation usually presents as an aggressive diffuse large B-cell lymphoma, occurs in up to 10% of patients with chronic lymphocytic leukaemia, has no approved therapies, and is associated with a poor prognosis. Pirtobrutinib has sh ... Full text Link to item Cite

Comprehensive Genomic Profiling in Non-Myeloid Hematologic Malignancies Identifies Variants That Can Alter Clinical Practice.

Journal article Hematology reports · September 2024 BackgroundComprehensive genomic profiling (CGP) is frequently adopted to direct the clinical care of myeloid neoplasms and solid tumors, but its utility in the care of lymphoid and histiocytic cancers is less well defined.MethodsIn this s ... Full text Cite

Comparison of differing dose levels of methotrexate for patients with primary central nervous system lymphoma.

Journal article J Oncol Pharm Pract · April 2024 INTRODUCTION: It has long been established that high-dose methotrexate is an essential part of therapy for primary central nervous system lymphoma. When regimens utilizing high-dose methotrexate were first studied, a dose of 8 g/m2 was used. More recently, ... Full text Link to item Cite

Integrative analysis of clinicopathological features defines novel prognostic models for mantle cell lymphoma in the immunochemotherapy era: a report from The North American Mantle Cell Lymphoma Consortium.

Journal article J Hematol Oncol · December 16, 2023 BACKGROUND: Patients with mantle cell lymphoma (MCL) exhibit a wide variation in clinical presentation and outcome. However, the commonly used prognostic models are outdated and inadequate to address the needs of the current multidisciplinary management of ... Full text Link to item Cite

Prevalence and significance of clonal hematopoiesis of indeterminate potential in lung transplant recipients.

Journal article BMC Pulm Med · October 30, 2023 BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP), the age-related acquisition of somatic mutations that leads to an expanded blood cell clone, has been associated with development of a pro-inflammatory state. An enhanced or dysregulated i ... Full text Link to item Cite

Parsaclisib, a PI3Kδ inhibitor, in relapsed and refractory follicular lymphoma (CITADEL-203): a phase 2 study.

Journal article EClinicalMedicine · September 2023 BACKGROUND: Parsaclisib, a potent and highly selective PI3Kδ inhibitor, has shown clinical benefit in patients with relapsed or refractory (R/R) B-cell malignancies. This phase 2 study (CITADEL-203; NCT03126019, EudraCT 2017-001624-22) assessed efficacy an ... Full text Link to item Cite

Combinatorial Efficacy and Toxicity of an Engineered Toxin Body MT-3724 with Gemcitabine and Oxaliplatin in Relapsed or Refractory Diffuse Large B Cell Lymphoma.

Journal article Cancer Invest · January 31, 2023 MT-3724 is an engineered direct-kill immunotoxin comprised of a CD20-specific scFv fused to a Shiga-like toxin subunit. In this phase IIa study, eight patients with relapsed diffuse large B-cell lymphoma were treated with MT-3724 combined with gemcitabine ... Full text Link to item Cite

Characterization of low-grade arthralgia, myalgia, and musculoskeletal pain with ibrutinib therapy: pooled analysis of clinical trials in patients with chronic lymphocytic leukemia and mantle cell lymphoma.

Journal article Leuk Lymphoma · July 2022 Joint and muscle pain, including arthralgia, myalgia, and musculoskeletal pain, are among the common adverse events (AEs) reported for ibrutinib, a once-daily Bruton's tyrosine kinase inhibitor approved for the treatment of various B-cell malignancies, inc ... Full text Link to item Cite

Dietary therapy in abdominal aortic aneurysm - Insights from clinical and experimental studies.

Journal article Front Cardiovasc Med · 2022 Abdominal aortic aneurysm (AAA) is a prevalent vascular disease with high mortality rates upon rupture. Despite its prevalence in elderly populations, there remain limited treatment options; invasive surgical repair, while risky, is the only therapeutic in ... Full text Link to item Cite

Primary Mediastinal (Thymic) Large B-Cell Lymphoma: Fidelity of Diagnosis Using WHO Criteria.

Journal article Clin Lymphoma Myeloma Leuk · May 2021 PURPOSE: Diagnosing primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is challenging because it is a clinicopathologic entity that shares characteristics with other lymphomas and lacks pathognomonic features. We sought to investigate the fidelity ... Full text Link to item Cite

Epigean Crayfish of the Potomac River Basin in West Virginia: Zoogeography, Natural History and Conservation

Journal article Freshwater Crayfish · April 15, 2021 AbstractCrayfish are an aquatic fauna of conservation concern, yet regional studies are lacking on zoogeography and life history. We compared recent and historical species distribution data and assessed conservation stan ... Full text Cite

Results and Clinical Utilization of Foundation Medicine Molecular Tumor Profiling in Uterine and Ovarian Cancers.

Journal article Target Oncol · January 2021 BACKGROUND: Recent advances in next-generation sequencing have allowed for an increase in molecular tumor profiling. OBJECTIVE: We sought to assess the actionability and clinical utilization of molecular tumor profiling results obtained via Foundation Medi ... Full text Link to item Cite

Implementation of a Molecular Tumor Registry to Support the Adoption of Precision Oncology Within an Academic Medical Center: The Duke University Experience.

Journal article JCO Precis Oncol · 2021 UNLABELLED: Comprehensive genomic profiling to inform targeted therapy selection is a central part of oncology care. However, the volume and complexity of alterations uncovered through genomic profiling make it difficult for oncologists to choose the most ... Full text Link to item Cite

Hodgkin Lymphoma, Version 2.2020, NCCN Clinical Practice Guidelines in Oncology.

Journal article J Natl Compr Canc Netw · June 2020 The NCCN Clinical Practice Guidelines in Oncology for Hodgkin Lymphoma (HL) provide recommendations for the management of adult patients with HL. The NCCN panel meets at least annually to review comments from reviewers within their institutions, examine re ... Full text Link to item Cite

Whole Exome and Transcriptome Sequencing in 1042 Cases Reveals Distinct Clinically Relevant Genetic Subgroups of Follicular Lymphoma.

Journal article Blood · November 13, 2019 DISCLOSURES: Koff: Burroughs Wellcome Fund: Research Funding; V Foundation: Research Funding; Lymphoma Research Foundation: Research Funding; American Association for Cancer Research: Research Funding. Leppä:Roche: Honoraria, Research Funding; Takeda: Hono ... Full text Link to item Cite

New horizons in the treatment and management of Lymphoma: Novel therapies for improved patient outcomes

Journal article Journal of Managed Care Medicine · January 1, 2019 The treatment of lymphoma continues to evolve with a better understanding of the genetics, cell markers, and tumor microenvironment which all play a role in the growth and proliferation of the disease. Several targeted and immunotherapies are now available ... Cite

Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer.

Journal article Cancer Discov · February 2018 "Liquid biopsy" approaches analyzing cell-free DNA (cfDNA) from the blood of patients with cancer are increasingly utilized in clinical practice. However, it is not yet known whether cfDNA sequencing from large cohorts of patients with cancer can detect ge ... Full text Link to item Cite

Factors shaping avian alien species richness in Australia vs Europe

Journal article Diversity and Distributions · November 2017 AbstractAimWe aim to examine the relative importance of human activity‐related and natural variables in shaping spatial patterns of alien bird species richness at the continental scale for ... Full text Cite

Thermal biology of Osmia cornifrons (Hymenoptera: Megachilidae) eggs and larvae

Journal article Journal of Apicultural Research · August 8, 2017 Full text Cite

Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2.

Journal article J Exp Med · May 1, 2017 Enteropathy-associated T cell lymphoma (EATL) is a lethal, and the most common, neoplastic complication of celiac disease. Here, we defined the genetic landscape of EATL through whole-exome sequencing of 69 EATL tumors. SETD2 was the most frequently silenc ... Full text Link to item Cite

The Genetic Basis of Hepatosplenic T-cell Lymphoma.

Journal article Cancer Discov · April 2017 Hepatosplenic T-cell lymphoma (HSTL) is a rare and lethal lymphoma; the genetic drivers of this disease are unknown. Through whole-exome sequencing of 68 HSTLs, we define recurrently mutated driver genes and copy-number alterations in the disease. Chromati ... Full text Link to item Cite

GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.

Journal article Blood · June 2, 2016 GNA13 is the most frequently mutated gene in germinal center (GC)-derived B-cell lymphomas, including nearly a quarter of Burkitt lymphoma and GC-derived diffuse large B-cell lymphoma. These mutations occur in a pattern consistent with loss of function. We ... Full text Link to item Cite

Connecting people and places: the emerging role of network governance in large landscape conservation

Journal article Frontiers in Ecology and the Environment · April 2016 The most important land and water issues facing North America and the world – including land‐use patterns, water management, biodiversity protection, and climate adaptation – require innovative governance arrangements. Most of these issues need to ... Full text Cite

Resolving water conflicts in the American West

Journal article Water Policy · August 1, 2015 The American West is defined first and foremost by aridity, scarcity, and variability of water resources. In response to this geographic imperative, the region has evolved a robust menu of legal, institutional, and community-based approaches to man ... Full text Cite

Merkel cell carcinoma with partial B-cell blastic immunophenotype: a potential mimic of cutaneous richter transformation in a patient with chronic lymphocytic lymphoma.

Journal article Am J Dermatopathol · February 2014 Merkel cell polyomavirus (MCPyV) is a DNA virus whose pathogenic mechanisms in Merkel cell carcinoma (MCC) are still being unraveled. Emerging reports of an association between MCPyV and chronic lymphocytic lymphoma (CLL) have begun to broaden our understa ... Full text Link to item Cite

Distribution of Chaetodactylus krombeini (Acari: Chaetodactylidae) within Osmia cornifrons (Hymenoptera: Megachilidae) nests: implications for population management.

Journal article Exp Appl Acarol · June 2013 Chaetodactylus krombeini (Baker) (Acari: Chaetodactylidae) is a cleptoparasitic mite that negatively affects propagation of Osmia spp. (Hymenoptera: Megachilidae) for orchard pollination in the USA. This study was conducted to determine the effect of C. kr ... Full text Link to item Cite

PAK1 mediates resistance to PI3K inhibition in lymphomas.

Journal article Clin Cancer Res · March 1, 2013 PURPOSE: The phosphoinositide 3-kinase (PI3K) pathway is known to play an active role in many malignancies. The role of PI3K inhibition in the treatment of lymphomas has not been fully delineated. We sought to identify a role for therapeutic PI3K inhibitio ... Full text Link to item Cite

The genetic landscape of mutations in Burkitt lymphoma.

Journal article Nat Genet · December 2012 Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other genetic mutations to the disease is largely unknown. Here, we describe the first completely sequenced genome from a Burkitt lymphoma tumor and germline DNA from the sam ... Full text Link to item Cite

Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function.

Journal article Cancer Gene Ther · January 2012 CD4+CD25+regulatory T cells (T(reg)) impair anti-tumor and anti-viral immunity. As there are higher T(reg) levels in cancer patients compared with healthy individuals, there is considerable interest in eliminating them or altering their function as part of ... Full text Link to item Cite

Erythropoietin for oncology supportive care.

Journal article Exp Cell Res · May 15, 2011 Recombinant human erythropoietin (rhEPO), the prototype erythropoiesis-stimulating agent developed in the 1980s, was among the first recombinant human proteins to be marketed for clinical use in the oncology setting. Anemia is a frequent concern in patient ... Full text Link to item Cite

Induction of Wilms' tumor protein (WT1)-specific antitumor immunity using a truncated WT1-expressing adenovirus vaccine.

Journal article Clin Cancer Res · April 15, 2009 PURPOSE: Wilms' tumor protein (WT1) is overexpressed in most leukemias and many solid tumors and is a promising target for tumor immunotherapy. WT1 peptide-based cancer vaccines have been reported but have limited application due to HLA restriction of the ... Full text Link to item Cite

Advances in immunotherapy for colorectal malignancies

Journal article Current Colorectal Cancer Reports · October 1, 2008 In the past decade, numerous advances have been made in resection, adjuvant treatment, and targeted therapies for colorectal malignancies; however, survival in the setting of metastatic disease treated with the most recent guideline-based therapy is only a ... Full text Cite

Evaluating Community-Based Collaboration on Federal Lands and Resources

Journal article Society & Natural Resources · April 9, 2008 Full text Cite

The promise and the challenge of cooperative conservation

Journal article FRONTIERS IN ECOLOGY AND THE ENVIRONMENT · March 2007 Link to item Cite