John Henry McCusker

Journal article Microbiology (Reading) · August 2002 Featured Work The Cryptococcus neoformans MET3 cDNA (encoding ATP sulfurylase) was cloned by complementation of the corresponding met3 mutation in Saccharomyces cerevisiae. Sequence analysis showed high similarity between the deduced amino acid sequence of the C. neofor ... Full text Link to item Cite

The tRNA-Tyr gene family of Saccharomyces cerevisiae: agents of phenotypic variation and position effects on mutation frequency.

Journal article Genetics · August 2002 Featured Work Extensive phenotypic diversity or variation exists in clonal populations of microorganisms and is thought to play a role in adaptation to novel environments. This phenotypic variation or instability, which occurs by multiple mechanisms, may be a form of ce ... Full text Link to item Cite

Dissecting the architecture of a quantitative trait locus in yeast.

Journal article Nature · March 21, 2002 Featured Work Most phenotypic diversity in natural populations is characterized by differences in degree rather than in kind. Identification of the actual genes underlying these quantitative traits has proved difficult. As a result, little is known about their genetic a ... Full text Link to item Cite

Development of Saccharomyces cerevisiae as a model pathogen. A system for the genetic identification of gene products required for survival in the mammalian host environment.

Journal article Genetics · October 2001 Featured Work Saccharomyces cerevisiae, a close relative of the pathogenic Candida species, is an emerging opportunistic pathogen. An isogenic series of S. cerevisiae strains, derived from a human clinical isolate, were used to examine the role of evolutionarily conserv ... Full text Link to item Cite

Whole genome genetic-typing in yeast using high-density oligonucleotide arrays.

Journal article Parasitology · 1999 Featured Work Genome sequence information in combination with new technologies has allowed researchers to approach genetic problems in new ways. High-density oligonucleotide arrays were used to probe the genome content of the yeast Saccharomyces cerevisiae. We show that ... Full text Link to item Cite