Megan Madonna

Conference Optical Molecular Probes Imaging and Drug Delivery Omp 2025 in Proceedings Optica Biophotonics Congress 2025 Part of Optica Biophotonics Congress Optics in the Life Sciences · January 1, 2025 Visualizing complex tumor-immune metabolic interactions is imperative to understanding cancer progression. Cocultures of 4T1 tumor cells and CD8+ T cells were imaged for glucose uptake and mitochondrial metabolism. Results point to poor immunogenic tumor p ... Full text Cite

Ignite: Place-based Community-centered Design to Promote Biomedical Engineering Efficacy

Conference ASEE Annual Conference and Exposition Conference Proceedings · January 1, 2025 This study evaluates the impact of Ignite’s Health programming, an informal engineering experience designed for middle and high school students and facilitated by Duke University undergraduate students. Participants design health-related projects such as p ... Full text Cite

[Work in progress: Intersection of Design and ”X” Research Papers] Global means local too: Integrating anti-oppressive practice into community-based capstone design projects.

Conference ASEE Annual Conference and Exposition Conference Proceedings · January 1, 2025 As global health challenges grow increasingly complex, engineering students are motivated to develop innovative solutions that are both technically sound and socially equitable. This paper presents the design and implementation of a senior capstone course ... Full text Cite

Development of a multi-scale imaging tool to quantify in vivo metabolic heterogeneity

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2024 We developed an approach to quantify intra-tumoral metabolic heterogeneity of in vivo tumor models by leveraging a computationally designed multi-scale microscope and a suite of exogenous fluorescent contrast agents to provide functional and structural inf ... Full text Cite

A Multiplexed Quantitative Spectroscopy Method to Measure Spectrally Overlapping Metabolic Fluorophores

Conference Novel Optical Materials and Applications Noma 2024 in Proceedings Advanced Photonics Congress 2024 Part of Optica Advanced Photonics Congress · January 1, 2024 We have developed and validated an in vivo quantitative spectroscopy method to measure spectrally overlapping fluorophores relevant to cancer metabolism using an inverse Monte Carlo algorithm and linear spectral unmixing. ... Cite

In Vivo Metabolic Imaging Reveals Mitochondrial Membrane Potential Reprogramming During Residual Disease Following Chemotherapy

Conference Optical Molecular Probes Imaging and Drug Delivery Omp 2023 · January 1, 2023 We performed intravital fluorescent microscopy in preclinical models of disease regression in Triple Negative Breast Cancer to compare dynamic, long-term in vivo changes across three major metabolic axes in chemotherapy-resistant and chemotherapy-sensitive ... Cite

Development of a multi-scale platform to quantify metabolic heterogeneity in vivo

Conference Optical Molecular Probes Imaging and Drug Delivery Omp 2023 · January 1, 2023 We developed an approach to quantify intratumoral metabolic heterogeneity of in vivo tumor models by leveraging a computationally designed multi-scale microscope and a suite of exogenous fluorescent contrast agents to provide functional and structural info ... Cite

In vivo metabolic imaging reveals mitochondrial membrane potential reprogramming following Her2-targeted therapy and dormant disease

Conference Optics Infobase Conference Papers · January 1, 2020 We performed in intravital fluorescent microscopy in a preclinical cancer dormancy model to capture key changes in mitochondrial activity associated with Her2 treated breast cancer both acutely and in a residual disease state. ... Cite

Integrated dual-modal microscope for imaging of key metabolic and vascular endpoints in preclinical cancer models

Conference Optics Infobase Conference Papers · January 1, 2016 We have developed and utilized a wide field, high resolution microscope to capture multiple key metabolic and vascular endpoints to different indolent from metastatic disease. ... Full text Cite

Longitudinal study of arteriogenesis with swept source optical coherence tomography and hyperspectral imaging

Conference Progress in Biomedical Optics and Imaging Proceedings of SPIE · January 1, 2013 Peripheral arterial disease (PAD) is an atherosclerotic disease of the extremities that leads to high rates of myocardial infarction and stroke, increased mortality, and reduced quality of life. PAD is especially prevalent in diabetic patients, and is comm ... Full text Cite