Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Adult and Pediatric Infectious Diseases Fellowship, Medicine And Pediatrics, Massachusetts General Hospital 2002 - 2004
  • Research Fellow in Infectious Diseases, Medicine, Emory University 2000 - 2002
  • Resident, Medicine And Pediatrics, University of Rochester 1996 - 2000
  • M.D.C.M., McGill University (Canada) 1996
• 

  Previous Appointments & Affiliations

  • Associate Research Professor of Global Health, Duke Global Health Institute, University Institutes and Centers 2017 - 2022
  • Instructor in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2016 - 2018
  • Adjunct Assistant Professor in the Department of Medicine, Medicine, Infectious Diseases, Medicine 2010 - 2016
• Expertise
• 

  Global Scholarship

  • Research

    • Malaysia (Country) 
• Research
• 

  Selected Grants

  • RADx-UP CDCC awarded by National Institutes of Health 2020 - 2025
  • Preparing for prospective cohort study of acute febrile illness and sepsis in Madagascar (Madagascar Research Site Implementation) awarded by Henry M. Jackson Foundation 2022 - 2023
  • Ph II randomized double blind placebo-controlled, study of LAM-002A for the preventation of progression of COVID-19 awarded by Yale University 2020 - 2023
  • Zika Diagnostics Development: Diagnosing recent and remote Zika infections awarded by University of North Carolina - Chapel Hill 2017 - 2022
  • Mapping Epigenetic Memory of Exposure New To Observe (MEMENTO) awarded by Defense Advanced Research Projects Agency 2019 - 2022
  • Effectiveness of PCV-10 to reduce severe viral acute lower respiratory infection in Bangladesh awarded by Thrasher Research Fund 2016 - 2021
  • InBios Dengue Study awarded by InBios International, Inc. 2017 - 2019
  • InBios Zika Study awarded by InBios International, Inc. 2018 - 2019
  • RICKETTSIAL INFECTIONS IN MALAYSIA awarded by National Institutes of Health 2014 - 2018
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Tsalik, Ephraim L., Cassandra Fiorino, Ammara Aqeel, Yiling Liu, Ricardo Henao, Emily R. Ko, Thomas W. Burke, et al. “The Host Response to Viral Infections Reveals Common and Virus-Specific Signatures in the Peripheral Blood.” Front Immunol 12 (2021): 741837. https://doi.org/10.3389/fimmu.2021.741837.
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    • McCollum, Eric D., Salahuddin Ahmed, Arun D. Roy, Nabidul H. Chowdhury, Holly B. Schuh, Syed J. R. Rizvi, Abu A. M. Hanif, et al. “Effectiveness of the 10-valent pneumococcal conjugate vaccine against radiographic pneumonia among children in rural Bangladesh: A case-control study.” Vaccine 38, no. 42 (September 2020): 6508–16. https://doi.org/10.1016/j.vaccine.2020.08.035.
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    • Reller, Megan E., and J Stephen Dumler. “Optimization and Evaluation of a Multiplex Quantitative PCR Assay for Detection of Nucleic Acids in Human Blood Samples from Patients with Spotted Fever Rickettsiosis, Typhus Rickettsiosis, Scrub Typhus, Monocytic Ehrlichiosis, and Granulocytic Anaplasmosis.” J Clin Microbiol 58, no. 9 (August 24, 2020). https://doi.org/10.1128/JCM.01802-19.
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    • Grigg, Matthew J., Timothy William, Emily G. Clemens, Kaajal Patel, Arjun Chandna, Christopher S. Wilkes, Bridget E. Barber, et al. “Rickettsioses as Major Etiologies of Unrecognized Acute Febrile Illness, Sabah, East Malaysia.” Emerg Infect Dis 26, no. 7 (July 2020): 1409–19. https://doi.org/10.3201/eid2607.191722.
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    • Tillekeratne, L Gayani, Sunil Suchindran, Emily R. Ko, Elizabeth A. Petzold, Champica K. Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, et al. “Previously Derived Host Gene Expression Classifiers Identify Bacterial and Viral Etiologies of Acute Febrile Respiratory Illness in a South Asian Population.” Open Forum Infect Dis 7, no. 6 (June 2020): ofaa194. https://doi.org/10.1093/ofid/ofaa194.
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    • Tillekeratne, L Gayani, Champica K. Bodinayake, Ryan Simmons, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara Arachchi, Bradly P. Nicholson, et al. “Respiratory Viral Infection: An Underappreciated Cause of Acute Febrile Illness Admissions in Southern Sri Lanka.” Am J Trop Med Hyg 100, no. 3 (March 2019): 672–80. https://doi.org/10.4269/ajtmh.18-0699.
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    • McCollum, Eric D., Salahuddin Ahmed, Nabidul H. Chowdhury, Syed J. R. Rizvi, Ahad M. Khan, Arun D. Roy, Abu Am Hanif, et al. “Chest radiograph reading panel performance in a Bangladesh pneumococcal vaccine effectiveness study.” Bmj Open Respir Res 6, no. 1 (2019): e000393. https://doi.org/10.1136/bmjresp-2018-000393.
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    • Bodinayake, Champica K., L Gayani Tillekeratne, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara Arachchi, John J. Strouse, October M. Sessions, et al. “Evaluation of the WHO 2009 classification for diagnosis of acute dengue in a large cohort of adults and children in Sri Lanka during a dengue-1 epidemic.” Plos Negl Trop Dis 12, no. 2 (February 2018): e0006258. https://doi.org/10.1371/journal.pntd.0006258.
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    • Reller, Megan E., and J Stephen Dumler. “Development and Clinical Validation of a Multiplex Real-Time Quantitative PCR Assay for Human Infection by Anaplasma phagocytophilum and Ehrlichia chaffeensis.” Trop Med Infect Dis 3, no. 1 (January 29, 2018). https://doi.org/10.3390/tropicalmed3010014.
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    • Fricken, Michael E. von, Sukhbaatar Lkhagvatseren, Bazartseren Boldbaatar, Pagbajab Nymadawa, Thomas A. Weppelmann, Bekh-Ochir Baigalmaa, Benjamin D. Anderson, Megan E. Reller, Paul M. Lantos, and Gregory C. Gray. “Estimated seroprevalence of Anaplasma spp. and spotted fever group Rickettsia exposure among herders and livestock in Mongolia.” Acta Trop 177 (January 2018): 179–85. https://doi.org/10.1016/j.actatropica.2017.10.015.
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    • Shapiro, David, Champica K. Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, Ruvini Kurukulasooriya, Jeremy Hsiang, Bradley Nicholson, et al. “Burden and Seasonality of Viral Acute Respiratory Tract Infections among Outpatients in Southern Sri Lanka.” Am J Trop Med Hyg 97, no. 1 (July 2017): 88–96. https://doi.org/10.4269/ajtmh.17-0032.
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    • Uehara, Anna, Hasitha Aravinda Tissera, Champica K. Bodinayake, Ananda Amarasinghe, Ajith Nagahawatte, L Gayani Tillekeratne, Jie Cui, et al. “Analysis of Dengue Serotype 4 in Sri Lanka during the 2012-2013 Dengue Epidemic.” Am J Trop Med Hyg 97, no. 1 (July 2017): 130–36. https://doi.org/10.4269/ajtmh.16-0540.
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    • Reller, Megan E., Ijeuru Chikeka, Jeremy J. Miles, J Stephen Dumler, Christopher W. Woods, Orlando Mayorga, and Armando J. Matute. “First Identification and Description of Rickettsioses and Q Fever as Causes of Acute Febrile Illness in Nicaragua.” Plos Negl Trop Dis 10, no. 12 (December 2016): e0005185. https://doi.org/10.1371/journal.pntd.0005185.
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    • Bodinayake, Champica K., L Gayani Tillekeratne, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara Arachichi, John J. Strouse, October M. Sessions, et al. “Emergence of Epidemic Dengue-1 Virus in the Southern Province of Sri Lanka.” Plos Negl Trop Dis 10, no. 10 (October 2016): e0004995. https://doi.org/10.1371/journal.pntd.0004995.
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    • Reller, Megan E., Aravinda M. de Silva, Jeremy J. Miles, Ramesh S. Jadi, Anne Broadwater, Katie Walker, Christopher Woods, Orlando Mayorga, and Armando Matute. “Unsuspected Dengue as a Cause of Acute Febrile Illness in Children and Adults in Western Nicaragua.” Plos Negl Trop Dis 10, no. 10 (October 2016): e0005026. https://doi.org/10.1371/journal.pntd.0005026.
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    • Chikeka, Ijeuru, Armando J. Matute, J Stephen Dumler, Christopher W. Woods, Orlando Mayorga, and Megan E. Reller. “Use of Peptide-Based Enzyme-Linked Immunosorbent Assay followed by Immunofluorescence Assay To Document Ehrlichia chaffeensis as a Cause of Febrile Illness in Nicaragua.” J Clin Microbiol 54, no. 6 (June 2016): 1581–85. https://doi.org/10.1128/JCM.03331-15.
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    • Bartlett, L. A., A. E. LeFevre, F. Mir, S. Soofi, S. Arif, D. K. Mitra, M. A. Quaiyum, et al. “The development and evaluation of a community-based clinical diagnosis tool and treatment regimen for postpartum sepsis in Bangladesh and Pakistan.” Reprod Health 13 (February 25, 2016): 16. https://doi.org/10.1186/s12978-016-0124-1.
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    • Shakoor, Sadia, Megan E. Reller, Amnesty LeFevre, Aneeta Hotwani, Shahida M. Qureshi, Farheen Yousuf, Mohammad Shahidul Islam, et al. “Diagnostic methods to determine microbiology of postpartum endometritis in South Asia: laboratory methods protocol used in the Postpartum Sepsis Study: a prospective cohort study.” Reprod Health 13 (February 25, 2016): 15. https://doi.org/10.1186/s12978-016-0121-4.
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    • Tillekeratne, L Gayani, Champica K. Bodinayake, Ajith Nagahawatte, Dhammika Vidanagama, Vasantha Devasiri, Wasantha Kodikara Arachchi, Ruvini Kurukulasooriya, et al. “Use of Rapid Influenza Testing to Reduce Antibiotic Prescriptions Among Outpatients with Influenza-Like Illness in Southern Sri Lanka.” Am J Trop Med Hyg 93, no. 5 (November 2015): 1031–37. https://doi.org/10.4269/ajtmh.15-0269.
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    • Tillekeratne, L Gayani, Champica K. Bodinayake, Ajith Nagahawatte, Dhammika Vidanagama, Vasantha Devasiri, Wasantha Kodikara Arachchi, Ruvini Kurukulasooriya, et al. “An under-recognized influenza epidemic identified by rapid influenza testing, southern Sri Lanka, 2013.” Am J Trop Med Hyg 92, no. 5 (May 2015): 1023–29. https://doi.org/10.4269/ajtmh.14-0708.
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    • Burbulis, Ian E., Kumiko Yamaguchi, Olga V. Nikolskaia, Sean T. Prigge, Stefan Magez, Sylvie Bisser, Megan E. Reller, and Dennis J. Grab. “Detection of pathogen-specific antibodies by loop-mediated isothermal amplification.” Clin Vaccine Immunol 22, no. 4 (April 2015): 374–80. https://doi.org/10.1128/CVI.00811-14.
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    • Reller, Megan E., Elsio A. Wunder, Jeremy J. Miles, Judith E. Flom, Orlando Mayorga, Christopher W. Woods, Albert I. Ko, J Stephen Dumler, and Armando J. Matute. “Unsuspected leptospirosis is a cause of acute febrile illness in Nicaragua.” Plos Negl Trop Dis 8, no. 7 (July 2014): e2941. https://doi.org/10.1371/journal.pntd.0002941.
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    • Sadreameli, Sara Christina, Megan E. Reller, David G. Bundy, James F. Casella, and John J. Strouse. “Respiratory syncytial virus and seasonal influenza cause similar illnesses in children with sickle cell disease.” Pediatr Blood Cancer 61, no. 5 (May 2014): 875–78. https://doi.org/10.1002/pbc.24887.
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    • Reller, Megan E., Wan Hsin Chen, Justin Dalton, Marguerite A. Lichay, and J Stephen Dumler. “Multiplex 5' nuclease quantitative real-time PCR for clinical diagnosis of malaria and species-level identification and epidemiologic evaluation of malaria-causing parasites, including Plasmodium knowlesi.” J Clin Microbiol 51, no. 9 (September 2013): 2931–38. https://doi.org/10.1128/JCM.00958-13.
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    • Reller, Megan E., Ufuoma Akoroda, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikaarachchi, John J. Strouse, Robert Chua, et al. “Chikungunya as a cause of acute febrile illness in southern Sri Lanka.” Plos One 8, no. 12 (2013): e82259. https://doi.org/10.1371/journal.pone.0082259.
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    • Reller, Megan E., Champica Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara-Arachichi, John J. Strouse, Judith E. Flom, Truls Østbye, Christopher W. Woods, and J Stephen Dumler. “Unsuspected rickettsioses among patients with acute febrile illness, Sri Lanka, 2007.” Emerg Infect Dis 18, no. 5 (May 2012): 825–29. https://doi.org/10.3201/eid1805.111563.
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    • Reller, M. E., and K. C. Carroll. “The authors' reply.” American Journal of Clinical Pathology 137, no. 3 (March 1, 2012): 495. https://doi.org/10.1309/AJCPXUM77MFORYSO.
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    • Prakash, John Antony Jude, T. Sohan Lal, Varghese Rosemol, Valsan Philip Verghese, Susanne A. Pulimood, Megan Reller, and John Stephen Dumler. “Molecular detection and analysis of spotted fever group Rickettsia in patients with fever and rash at a tertiary care centre in Tamil Nadu, India.” Pathog Glob Health 106, no. 1 (March 2012): 40–45. https://doi.org/10.1179/2047773212Y.0000000001.
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    • Reller, Megan E., Champika Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara-Arachichi, John J. Strouse, Anne Broadwater, Truls Østbye, Aravinda de Silva, and Christopher W. Woods. “Unsuspected dengue and acute febrile illness in rural and semi-urban southern Sri Lanka.” Emerg Infect Dis 18, no. 2 (February 2012): 256–63. https://doi.org/10.3201/eid1802.110962.
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    • Schachterle, Stephen E., George Mtove, Joshua P. Levens, Emily G. Clemens, Lirong Shi, Amirita Raj, Beatrice Munoz, et al. “Prevalence and density-related concordance of three diagnostic tests for malaria in a region of Tanzania with hypoendemic malaria.” J Clin Microbiol 49, no. 11 (November 2011): 3885–91. https://doi.org/10.1128/JCM.01157-11.
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    • Reller, Megan E., Emily G. Clemens, Steve E. Schachterle, George A. Mtove, David J. Sullivan, and J Stephen Dumler. “Multiplex 5' nuclease-quantitative PCR for diagnosis of relapsing fever in a large Tanzanian cohort.” J Clin Microbiol 49, no. 9 (September 2011): 3245–49. https://doi.org/10.1128/JCM.00940-11.
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    • Reller, Megan E., Champika Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, Wasantha Kodikara-Arachichi, John J. Strouse, Judith E. Flom, J Stephen Dumler, and Christopher W. Woods. “Leptospirosis as frequent cause of acute febrile illness in southern Sri Lanka.” Emerg Infect Dis 17, no. 9 (September 2011): 1678–84. https://doi.org/10.3201/eid1709.100915.
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    • Strouse, John J., Megan E. Reller, David G. Bundy, Martha Amoako, Maria Cancio, Rachel N. Han, Alexandra Valsamakis, and James F. Casella. “Severe pandemic H1N1 and seasonal influenza in children and young adults with sickle cell disease.” Blood 116, no. 18 (November 4, 2010): 3431–34. https://doi.org/10.1182/blood-2010-05-282194.
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    • Reller, Megan E., Romina C. Alcabasa, Clara A. Lema, and Karen C. Carroll. “Comparison of two rapid assays for Clostridium difficile Common antigen and a C difficile toxin A/B assay with the cell culture neutralization assay.” Am J Clin Pathol 133, no. 1 (January 2010): 107–9. https://doi.org/10.1309/AJCPO3QWOU8CYGEU.
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    • Prakash, J. A. J., M. E. Reller, N. Barat, and J. S. Dumler. “Assessment of a quantitative multiplex 5' nuclease real-time PCR for spotted fever and typhus group rickettsioses and Orientia tsutsugamushi.” Clin Microbiol Infect 15 Suppl 2 (December 2009): 292–93. https://doi.org/10.1111/j.1469-0691.2008.02242.x.
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    • Reller, Megan E., Anita K. M. Zaidi, Shazia Sultana, Shazia Azeem, Beenish Hanif, Shahida Qureshi, Rumina Hasan, Zulfiqar Bhutta, Rehana Akhter, and Donald A. Goldmann. “Controlled evaluation of Bactec Peds Plus/F and Bactec lytic/10 anaerobic/F media for isolation of Salmonella enterica serovars typhi and paratyphi A from blood.” J Clin Microbiol 47, no. 1 (January 2009): 245–46. https://doi.org/10.1128/JCM.01452-08.
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    • Reller, M. E., R. V. Tauxe, L. A. Kalish, and K. Mølbak. “Excess salmonellosis in women in the United States: 1968-2000.” Epidemiol Infect 136, no. 8 (August 2008): 1109–17. https://doi.org/10.1017/S0950268807009594.
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    • Chang, L. W., M. E. Reller, J. A. Bishop, K. Talaat, T. B. Nutman, and P. G. Auwaerter. “A 41-year-old woman from Cameroon with infertility.” Clinical Infectious Diseases 47, no. 1 (July 1, 2008). https://doi.org/10.1086/588786.
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    • Chang, Larry W., Megan E. Reller, Justin A. Bishop, Kawsar Talaat, Thomas B. Nutman, and Paul G. Auwaerter. “A 41-year-old woman from Cameroon with infertility.” Clin Infect Dis 47, no. 1 (July 1, 2008): 141–109. https://doi.org/10.1086/588787.
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    • Reller, Megan E., Amanda B. Mallonee, Nicole P. Kwiatkowski, and William G. Merz. “Use of peptide nucleic acid-fluorescence in situ hybridization for definitive, rapid identification of five common Candida species.” J Clin Microbiol 45, no. 11 (November 2007): 3802–3. https://doi.org/10.1128/JCM.01127-07.
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    • Reller, Megan E., Clara A. Lema, Trish M. Perl, Mian Cai, Tracy L. Ross, Kathleen A. Speck, and Karen C. Carroll. “Yield of stool culture with isolate toxin testing versus a two-step algorithm including stool toxin testing for detection of toxigenic Clostridium difficile.” J Clin Microbiol 45, no. 11 (November 2007): 3601–5. https://doi.org/10.1128/JCM.01305-07.
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    • Reller, Megan E., Richard W. Douce, Susan E. Maslanka, Darwin S. Torres, Stephen R. Manock, and Jeremy Sobel. “Wound botulism acquired in the Amazonian rain forest of Ecuador.” Am J Trop Med Hyg 74, no. 4 (April 2006): 628–31.
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    • Reller, Megan E., Jennifer M. Nelson, Kåre Mølbak, David M. Ackman, Dianna J. Schoonmaker-Bopp, Timothy P. Root, and Eric D. Mintz. “A large, multiple-restaurant outbreak of infection with Shigella flexneri serotype 2a traced to tomatoes.” Clin Infect Dis 42, no. 2 (January 15, 2006): 163–69. https://doi.org/10.1086/498900.
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    • Kalluri, Pavani, Colleen Crowe, Megan Reller, Linda Gaul, James Hayslett, Suzanne Barth, Stacey Eliasberg, et al. “An outbreak of foodborne botulism associated with food sold at a salvage store in Texas.” Clin Infect Dis 37, no. 11 (December 1, 2003): 1490–95. https://doi.org/10.1086/379326.
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    • Varma, Jay K., Katherine D. Greene, Megan E. Reller, Stephanie M. DeLong, Janine Trottier, Scott F. Nowicki, Mary DiOrio, et al. “An outbreak of Escherichia coli O157 infection following exposure to a contaminated building.” Jama 290, no. 20 (November 26, 2003): 2709–12. https://doi.org/10.1001/jama.290.20.2709.
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    • Reller, Megan E., Carlos E. Mendoza, M Beatriz Lopez, Maricruz Alvarez, Robert M. Hoekstra, Christy A. Olson, Kathleen G. Baier, Bruce H. Keswick, and Stephen P. Luby. “A randomized controlled trial of household-based flocculant-disinfectant drinking water treatment for diarrhea prevention in rural Guatemala.” Am J Trop Med Hyg 69, no. 4 (October 2003): 411–19.
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    • Reller, Megan E., Sonja J. Olsen, Amy B. Kressel, Troy D. Moon, Kristy A. Kubota, Malcolm P. Adcock, Scott F. Nowicki, and Eric D. Mintz. “Sexual transmission of typhoid fever: a multistate outbreak among men who have sex with men.” Clin Infect Dis 37, no. 1 (July 1, 2003): 141–44. https://doi.org/10.1086/375590.
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    • Reller, M. E., Y. J. M. Mong, R. M. Hoekstra, and R. E. Quick. “Erratum: Cholera prevention with traditional and novel water treatment methods: An outbreak investigation in Fort-Dauphin, Madagascar. (American Journal of Public Health (2001) 91 (1608-1610)).” American Journal of Public Health 92, no. 4 (January 1, 2002): 508.
    • Reller, M. E., Y. J. Mong, R. M. Hoekstra, and R. E. Quick. “Cholera prevention with traditional and novel water treatment methods: an outbreak investigation in Fort-Dauphin, Madagascar.” Am J Public Health 91, no. 10 (October 2001): 1608–10. https://doi.org/10.2105/ajph.91.10.1608.
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    • Kachur, S. P., M. E. Reller, A. M. Barber, L. M. Barat, E. H. A. Koumans, M. E. Parise, J. Roberts, T. K. Ruebush, and J. R. Zucker. “Malaria Surveillance - United States, 1994.” Morbidity and Mortality Weekly Report 46, no. SUPPL. 5 (October 17, 1997): 1–16.

  • Book Sections

    • Reller, M. E. “Salmonella Species.” In Principles and Practice of Pediatric Infectious Diseases, 837–42, 2017. https://doi.org/10.1016/B978-0-323-40181-4.00146-8.
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    • Reller, M. E. “Salmonella Species.” In Principles and Practice of Pediatric Infectious Diseases: Fourth Edition, 814-819.e2, 2012. https://doi.org/10.1016/B978-1-4377-2702-9.00148-3.
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  • Conference Papers

    • Mutucumarana, Charmaine P., Champica K. Bodinayake, Ajith Nagahawatte, Vasantha Devasiri, Ruvini Kurukulasooriya, Thamali Anuradha, Aruna Dharshan De Silva, et al. “Geospatial analysis of dengue emergence in rural areas in the Southern Province of Sri Lanka.” In Trans R Soc Trop Med Hyg, 114:408–14, 2020. https://doi.org/10.1093/trstmh/trz123.
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