Michael Caminear

Journal article Cell Rep · July 28, 2026 Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine cancer that is typically metastatic upon diagnosis and has poor overall survival. Here we report that the inactivation of ABL tyrosine kinases impairs the outgrowth of metastatic SCLC tumo ... Full text Open Access Link to item Cite

UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer

Journal article Journal of Experimental & Clinical Cancer Research · October 19, 2023 AbstractBackgroundEpithelial ovarian cancer (EOC) is a global health burden, with the poorest five-year survival rate of the gy ... Full text Cite

ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1.

Journal article Proc Natl Acad Sci U S A · April 18, 2023 The hypoxia-inducible factor 1-α (HIF-1α) enables cells to adapt and respond to hypoxia (Hx), and the activity of this transcription factor is regulated by several oncogenic signals and cellular stressors. While the pathways controlling normoxic degradatio ... Full text Open Access Link to item Cite

Disulfiram Transcends ALDH Inhibitory Activity When Targeting Ovarian Cancer Tumor-Initiating Cells

Journal article Frontiers in Oncology · March 17, 2022 Epithelial ovarian cancer (EOC) is a global health burden and remains the fifth leading cause of cancer related death in women worldwide with the poorest five-year survival rate of the gynecological malignancies. EOC recurrence is considered to be ... Full text Open Access Cite

Drugs Targeting Tumor-Initiating Cells Prolong Survival in a Post-Surgery, Post-Chemotherapy Ovarian Cancer Relapse Model

Journal article Cancers · June 21, 2020 Disease recurrence is the major cause of morbidity and mortality of ovarian cancer (OC). In terms of maintenance therapies after platinum-based chemotherapy, PARP inhibitors significantly improve the overall survival of patients with BRCA mutations ... Full text Open Access Cite