Scholars@Duke
Michael Mackenzie Lee Dore

Michael Mackenzie Lee Dore

Medical Associate Professor in the Department of Medicine
Medicine, Hospital Medicine
michael.dore@duke.edu
Box 90978, Durham, NC 27708-0978
Duke University School of Medicine, Department of Medicine, Durham, NC 27708

Scholarly Works

Model-based evaluation of colorectal cancer screening effectiveness: three rounds of multitarget stool DNA testing versus one colonoscopy.

Journal article Journal of medical economics · December 2026 BackgroundSeveral colorectal cancer (CRC) screening modalities are guideline-recommended in the United States but differ in screening interval and real-world adherence. Accordingly, single-round test performance may not reflect cumulative effectiv ... Full text Cite

Outcomes of Acute PE Treated With DOACs in the Veterans Affairs Health System: A Retrospective Cohort Study.

Journal article Acad Emerg Med · June 2026 BACKGROUND: Although guidelines support outpatient management for low-risk pulmonary embolism, U.S. emergency department (ED) adoption remains low, partly due to limited contemporary evidence. Direct oral anticoagulant (DOAC) era studies are small or Europ ... Full text Link to item Cite

Comparison of Benefit-to-Burden Ratios for Stool-Based Colorectal Cancer Screening Tests in the U.S.: A Decision Analytical Modeling Approach.

Journal article AJPM Focus · February 2026 INTRODUCTION: The U.S. Preventive Services Task Force recommends average-risk colorectal cancer screening beginning at age 45 years with the multitarget stool DNA test at 1-3-year intervals or annual fecal immunochemical tests. In this decision analytical ... Full text Link to item Cite

Value of Stool-Based Colorectal Cancer Screening: Integrating Real-World Adherence, Detection, and Prevention in a Cohort-Based Modeling Analysis.

Journal article J Clin Med · December 20, 2025 Background/Objectives: Modeling analyses for colorectal cancer (CRC) screening focusing solely on the costs of screening do not fully capture the value of screening programs. We evaluated the clinical and economic effects of CRC stool-based screening tests ... Full text Link to item Cite

High Adherence to Repeat Multitarget Stool DNA Testing and Follow-Up Colonoscopy in Average-Risk United States Adults: Results from a Nationally Insured Cohort.

Journal article Clin Ther · November 28, 2025 PURPOSE: Colorectal cancer (CRC) is a leading cause of cancer-related deaths in the United States, despite available screening programs, making regular screening essential for early detection and prevention. This study evaluated adherence to repeat multita ... Full text Link to item Cite

Patient and physician preferences among colorectal cancer screening tests: updated predictions from a discrete choice experiment.

Journal article Curr Med Res Opin · October 2025 OBJECTIVE: Colorectal cancer (CRC) screening rates fall short of national goals. This study aimed to understand eligible individuals' preferences regarding CRC screening modalities to improve screening adherence. METHODS: Two cohorts took a discrete choice ... Full text Link to item Cite

S5963 When the Gradient Fails: Unexplained Recurrent Low SAAG Ascites

Journal article American Journal of Gastroenterology · October 1, 2025 Full text Cite

Adherence to Multitarget Stool DNA Testing in Individuals Aged 45-49 Years With Average Risk for Colorectal Cancer.

Journal article Clin Transl Gastroenterol · September 1, 2025 INTRODUCTION: Recommendations for colorectal cancer (CRC) screening have been updated to include individuals aged 45-49 years, addressing recent increases in CRC rates among young adults. The multitarget stool DNA (mt-sDNA) test is approved for average-ris ... Full text Link to item Cite

Utilization of colorectal cancer screening modalities in the United States (2017-2023): a national multi-payer claims database analysis.

Journal article Curr Med Res Opin · September 2025 BACKGROUND: Colorectal cancer (CRC) is the second leading cause of U.S. cancer mortality. This study evaluated the utilization of CRC screening modalities from 2017 to 2023. METHODS: This retrospective, cross-sectional study analyzed data from 2017 to 2023 ... Full text Link to item Cite

Transition to oral beta-lactam therapy in uncomplicated gram-negative bacteremia: A systematic review and meta-analysis.

Journal article J Hosp Med · August 2025 INTRODUCTION: Gram-negative bacteremia (GNB) is associated with significant morbidity and mortality. Transition to oral therapy has traditionally utilized fluoroquinolones or trimethoprim-sulfamethoxazole rather than beta-lactams due to concerns about phar ... Full text Link to item Cite

Multi-Target Stool DNA and the Fecal Immunochemical Test: A Systematic Review and Meta-Analysis on Test Performances.

Journal article Am J Prev Med · August 2025 INTRODUCTION: Colorectal cancer remains a leading cause of cancer death in the U.S. Since the latest U.S. Preventive Services Task Force update, additional studies examining the performance of the multi-target stool DNA and the fecal immunochemical test ha ... Full text Link to item Cite

Re-screening adherence to multi-target stool DNA test for colorectal cancer: real-world study in a large national population.

Journal article Int J Colorectal Dis · February 24, 2025 PURPOSE: Adherence to colorectal cancer (CRC) re-screening is essential to maximize screening effectiveness. This study assessed adherence to a multi-target stool DNA (mt-sDNA) test among previous users in the USA across different payer types. METHODS: Dat ... Full text Link to item Cite

Adherence to multi-target stool DNA test in the US Asian population from 2017-2024.

Conference Journal of Clinical Oncology · February 2025 101Background: In 2024, incidence and mortality cases related to colorectal cancer (CRC) in the US are estimated to reach 152 ... Full text Cite

Multi-target stool DNA test adherence among average-risk 45- to 49-year-old patients from 2017-2023.

Conference Journal of Clinical Oncology · February 2025 102Background: Colorectal cancer (CRC) is the third most common cancer in the United States and the second most common cause ... Full text Cite

Multi-target stool-DNA test for colorectal cancer screening and effects on health and economic outcomes compared to blood-based tests: Influence of adherence.

Conference Journal of Clinical Oncology · February 2025 88Background: There are an estimated 60 million individuals in the US who are not up-to-date with average-risk colorectal can ... Full text Cite

Trends in utilization of colorectal cancer screening modalities among patients with average risk in the United States from 2017 to 2023.

Conference Journal of Clinical Oncology · February 2025 98Background: Colorectal cancer (CRC) is the second leading cause of cancer mortality in the US. The national CRC screening r ... Full text Cite

Comparison of screening outcomes associated with advanced precancerous lesion versus colorectal cancer sensitivity for a blood-based test: A simulation study.

Conference Journal of Clinical Oncology · February 2025 89Background: With estimates of over 150,000 incident and 50,000 fatal colorectal cancer (CRC) cases in 2024, efforts are ong ... Full text Cite

Adherence to multi-target stool DNA testing for colorectal cancer screening in the United States.

Journal article Int J Colorectal Dis · January 17, 2025 PURPOSE: Colorectal cancer (CRC) is the second leading cause of cancer mortality in the USA and is highly preventable, with early screening vital for improving outcomes. This study aimed to evaluate adherence rates of multi-target stool DNA (mt-sDNA) testi ... Full text Link to item Cite

Real-World Adherence to Multi-Target Stool DNA Testing for Colorectal Cancer Among Asian Americans.

Journal article Cancer Control · 2025 Introduction: Asian Americans have lower colorectal cancer (CRC) screening rates compared to other racial/ethnic groups. Given the importance of early detection and subsequent treatment in improving survival, this study examines adherence to first-time mul ... Full text Link to item Cite

Clearance of penicillin allergies via direct oral provocation testing (DOPT): a systematic review.

Journal article Antimicrob Steward Healthc Epidemiol · 2025 OBJECTIVE: Penicillin allergies are reported in 10-15% of the US population, but the actual rate is less than 1%. Inappropriate penicillin allergies are associated with adverse patient outcomes, poor antimicrobial stewardship, and increased healthcare cost ... Full text Link to item Cite

Tobacco use Prevalence in the Military Health System: A Retrospective Study.

Journal article Mil Med · November 5, 2024 INTRODUCTION: Tobacco use is prevalent and has traditionally been higher in the U.S. Military population than in the civilian population, but studies are limited. The goal of this study was to evaluate tobacco use and tobacco cessation counseling within th ... Full text Link to item Cite

Cervical Cancer Screening in the United States Military Health System During the COVID-19 Pandemic.

Journal article Cureus · November 2024 Introduction During the COVID-19 pandemic, healthcare systems implemented restrictions on in-person appointments to mitigate viral spread among healthcare workers and patients. This study assesses changes in cervical cancer screening (CCS) rates within the ... Full text Link to item Cite

Traumatic Brain Injury and Subsequent Risk of Brain Cancer in US Veterans of the Iraq and Afghanistan Wars.

Journal article JAMA Netw Open · February 5, 2024 IMPORTANCE: While brain cancer is rare, it has a very poor prognosis and few established risk factors. To date, epidemiologic work examining the potential association of traumatic brain injury (TBI) with the subsequent risk of brain cancer is conflicting. ... Full text Link to item Cite

Association of Traumatic Brain Injury and Glioblastoma Multiforme: A Case Series.

Journal article Mil Med · January 23, 2024 Glioblastoma multiforme (GBM) is an aggressive variant of central nervous system gliomas that carries a dismal prognosis. Although GBM is the most frequently occurring and malignant type of glioma accounting for more than 60% of all brain tumors in adults, ... Full text Link to item Cite

A Case Series of Ocular Syphilis Cases at Military Treatment Facility From 2020 to 2021.

Journal article Mil Med · January 23, 2024 Syphilis is a sexually transmitted infection, caused by the spirochete Treponema pallidum, that can lead to multi-organ involvement. In 2020, over 138,000 cases were reported in the United States equating to a case report of 40.8 per 100,000 people. Ocular ... Full text Link to item Cite

Member Adherence to a Health Insurer-Sponsored Gap Closure Program Using Multi-Target Stool DNA Test for Colorectal Cancer Screening.

Journal article J Prim Care Community Health · 2024 OBJECTIVES: To describe member adherence to a mail-based, health insurer-sponsored gap closure program for colorectal cancer (CRC) screening using multi-target stool DNA (mt-sDNA; Cologuard®) tests. METHODS: Combined patient data from Exact Sciences Labora ... Full text Link to item Cite

Primary Cardiac Angiosarcoma: Pericardial Erosion and Disseminated Metastasis in a Young Active Duty Man

Journal article Annals of Internal Medicine Clinical Cases · August 1, 2022 Primary cardiac tumors are exceedingly rare with a reported prevalence of 0.0017% to 0.028%. Seventy-five percent of these tumors are benign. Of the primary malignant tumors, the most common are sarcomas. Primary cardiac sarcomas are often rapidly progress ... Full text Cite

Observations on home HIV testing.

Journal article AIDS · July 17, 2015 Full text Link to item Cite